LKB1: Controlling Quiescence and Genomic Integrity at Home

Publication date: Available online 5 April 2018
Source:Trends in Endocrinology & Metabolism
Author(s): Carmen Berasain, Matías A. Ávila
The pleiotropic liver kinase B1 (LKB1) controls metabolism, cell polarity, and proliferation in an apparently cell- and context-specific manner. A recent study in Cell Reports has demonstrated that LKB1 is essential to maintain the characteristic quiescence of the liver and to secure genomic integrity during liver regeneration independently of AMPK.



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