Architecture of PRC2 Holo Complexes

Publication date: Available online 3 May 2018
Source:Trends in Biochemical Sciences
Author(s): Kendra R. Vann, Tatiana G. Kutateladze
Polycomb repressive complex 2 (PRC2) is a chief epigenetic regulator. In a new article, Chen et al. describe the crystal structure of the heterotetrameric PRC2 holo complex, which provides important mechanistic insights into the organization of its subunits and the association of PRC2 with chromatin.



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