Intraepidermal nerve fibres are not the exclusive tranducers of nociception

Publication date: Available online 19 May 2018
Source:Journal of Neuroscience Methods
Author(s): Matthieu Talagas, Nicolas Lebonvallet, Laurent Misery
This article is a commentary on a article entitled Micropatterned surface electrode for massive selective stimulation of intraepidermal nociceptive fibres and published last January in your journal (Leandri et al., 2018 Jan 1; 293; 17–26). The goal of this article is to provide an insight of the most recent datas on cutaneous nociception. Indeed recent studies have demonstrated that keratinocytes closely participate in sensory transduction, and therefore, intraepidermal free nerve endings are not exclusive transducers of pain. Therefore, the results presented by Leandri et al., should be interpreted in the light of this information.



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