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Παρασκευή 1 Ιουνίου 2018

Mesenchymal Stromal Cells: Clinical Challenges and Therapeutic Opportunities

Publication date: 1 June 2018
Source:Cell Stem Cell, Volume 22, Issue 6
Author(s): Jacques Galipeau, Luc Sensébé
Mesenchymal stromal cells (MSCs) have been the subject of clinical trials for more than a generation, and the outcomes of advanced clinical trials have fallen short of expectations raised by encouraging pre-clinical animal data in a wide array of disease models. In this Perspective, important biological and pharmacological disparities in pre-clinical research and human translational studies are highlighted, and analyses of clinical trial failures and recent successes provide a rational pathway to MSC regulatory approval and deployment for disorders with unmet medical needs.

Teaser

In this Perspective, Galipeau and Sensébé highlight important biological and pharmacological disparities in pre-clinical research and human translational studies. The authors also analyze clinical trial failures and recent successes to discuss a rational pathway toward MSC regulatory approval and deployment for disorders with unmet medical needs.


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