The association between treatment reactions and treatment efficiency of HMME-photodynamic therapy on port wine stains: a prospective double blind randomized controlled trial

Publication date: Available online 13 February 2017
Source:Photodiagnosis and Photodynamic Therapy
Author(s): Yan Tang, Hongfu Xie, Ji Li, Dan Jian
BackgroundPlenty of researches focused on treatment efficiency and/or treatment reactions of photodynamic therapy (PDT) on port-wine stain (PWS). But few studies reported the association between them. Hence, here we investigated the association between the treatment efficiency and treatment reactions after Hemoporfin mediated photodynamic therapy (HMME-PDT) on PWS through a prospective study.MethodsPatients (n=50) with PWS were randomly assigned to the HMME group or the placebo group. Three of them quitted after the first treatment, and forty-seven of them received two sessions of treatment at an 8-week interval. They were given the treatment at day 1 and evaluations were performed at day 1, 4 and week 8 in each session. HMME group was treated with HMME while the placebo group was given normal saline instead in the first session double-blindly. While in the second session, both groups received HMME-PDT treatment.ResultsAfter a single treatment, swelling was more severe in younger patients (p <0.05) and the lesion farer from centro-facial showed more severe pruritus and scab. Compared with a single treatment, burning sensation had a higher occurrence rate, while burning sensation and scab were less severe in the second treatment. Importantly, severity of scab and pain (5min after irradiation) were found possibly correlated with the treatment efficiency.ConclusionHMME-PDT on PWS induces several treatment reactions, including pruritus, burning sensation, pain, swelling, blisters and scab. Two sessions of treatments does not have any accumulation effects on treatment reactions. And there might be a positive correlation between treatment efficiency and the severity of scab or pain (at early stage of the therapy), which might help in regulating treatment modalities.



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