Netrin-1 improves the amyloid-β-mediated suppression of memory and synaptic plasticity

Publication date: Available online 4 April 2017
Source:Brain Research Bulletin
Author(s): Mohammad Shabani, Masoud Haghani, Parisa Esmaeili Tazangi, Mahnaz Bayat, Seyed Mostafa Shid Moosavi, Hoda Ranjbar
The aim of this study was to investigate the effects of netrin-1 (NT-1) on amyloid-beta (Aβ)–induced impairments in learning-memory and synaptic plasticity.The NT-1 or its vehicle was administered four times into the Aβ+NT or Aβ+V groups, respectively. The Aβ+SNT group received a single dose of NT-1. The Aβ+HNT group received heat-inactivated NT-1. For the learning-memory and synaptic plasticity assessment, field potentials recording and behavioral experiment were used.Bilateral injection of Aβ1-42 inhibits induction of long-term potentiation (LTP)and decreased memory performance in all the behavioral tasks. However, only by repeated injection of NT-1, significant recovery of LTP and memorywas seen. Although, the delivery of HFS to Aβ+NT group recovered EPSP slope of the maintenance phase when compared with Aβ+V, but it failed torecover the induction phase.It can be assumed that NT-1 may have regulatory effects on the synthesis of key proteins and/or structural changes that are responsible for LTP induction, since the protein synthesis and/or structural changes are required for the maintenance phase of LTP.



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