Prognostic role of Histologic regression in primary cutaneous melanoma: A Systematic Review and Meta-analysis

Abstract

Introduction

The prognostic significance of histological regression in primary melanoma has been debated for many years. We aim to review the evidence to see how histological regression may affect prognosis.

Methods

A systematic review was performed by searching in MEDLINE, Scopus, and the Cochrane Library from January 1^st,1966, through August 1st 2015. All studies reporting HR or data on survival and histological regression were included.

Primary random-effects meta-analyses were used to summarise outcome measures. Heterogeneity was assessed using the χ2 test and I2 statistic. To assess the potential bias of small studies we used funnel plots and the Begg and Mazumdar adjusted rank correlation method. Summary of survival outcomes were measured as Hazard Risks or Relative risk of death at 5 years according to the presence of histological regression of primary melanoma.

Results

183 articles were reviewed out of 1876. 10 studies comprised of 8557 patients were included. Patients with histological regression had a lower Relative Risk of death (0.772;95%CI, 0.612-0.973) than those without. Examination of the funnel plot did not provide evidence of publication bias.

Conclusion

The results showed that histological regression is a protective factor for survival.

This article is protected by copyright. All rights reserved.

http://ift.tt/2nKpLUY