Autologous Hematopoietic Stemcell Transplantation for Multiple Sclerosis [Internet].

Autologous hematopoietic stem cell transplantation is a treatment that has been suggested for a small group of patients with relapsing remitting multiple sclerosis where available medication has limited effect or causes serious side effects. In this Health Technology Assessment we have summarized and evaluated research of efficacy, safety, economic evaluations and ethical considerations related to autologous stem cell transplantation for multiple sclerosis. We did not identify any controlled study, with the exception of one very small randomized controlled trial with limited relevance. The other studies were one registry study and 21 smaller case series, of which eight mainly comprised relapsing-remitting multiple sclerosis. We assessed the quality of the evidence as low for mortality at 100 days, and very low for all other outcomes. There is considerable uncertainty linked to the results. We found that:

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