Htr2c Splice Variants and 5HT2CR-Mediated Appetite

Publication date: Available online 9 May 2017
Source:Trends in Endocrinology & Metabolism
Author(s): Anthony R. Isles
Serotonin 2C receptor (5HT2CR) exists as different isoforms as a result of alternate splicing. A truncated variant (5HT2CR-trunc) has no canonical receptor function and yet shows robust expression levels throughout the brain. Recent work has demonstrated the biochemical role of this isoform and how altering levels of 5HT2CR-trunc leads to changes in behaviour.



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