Histological case control study of peeling-induced skin changes of different peeling agents in surgically subcutaneous undermined skin flaps in facelift patients

A histological evaluation of peeling-induced skin changes in subcutaneous undermined preauricular facial skin flaps of 9 patients was performed. There were 3 treatment groups Trichloroacetic acid (TCA) 25%, TCA 40% and phenol/croton oil; 1 group served as control. Two independent evaluators determined the epidermal and dermal thickness and the depth of necrosis (μm). The percentual tissue damage due to the peeling was calculated and a one sample t-test for statistical significance was performed.

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