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Δευτέρα 26 Ιουνίου 2017

Is there an advantage in onset of action with mixing lignocaine and bupivacaine?

Ever since Lidocaine (lignocaine) was first synthesised in 1943 and Bupivacaine first synthesised in 1957, surgeons have been mixing these two local anaesthetics. Lidocaine with its shorter duration of action has been linked (inaccurately) with a more rapid onset of action while the longer duration of Bupivacaine has again been suggested to have a slower onset of action. This erroneous extrapolation has led to many mixing the two to have an anaesthetic solution which might have rapid onset and long duration.

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