Does Too Much MAGIC Lead to Mitophagy?

Publication date: Available online 19 May 2018
Source:Trends in Biochemical Sciences
Author(s): Mohamed A. Eldeeb, Richard P. Fahlman
Neurodegeneration-associated hallmarks include an abundance of protein aggregates and amelioration of mitochondrial function. Despite the knowledge of molecular counteracting mechanisms, the molecular dialogue between protein aggregate accumulation and aberrant mitochondrial import is poorly understood. Recent work unraveled a novel role for the mitochondrial import machinery in regulating cytosolic proteostasis.



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