KRAS Activating Signaling Triggers Arteriovenous Malformations

Publication date: Available online 7 May 2018
Source:Trends in Biochemical Sciences
Author(s): Feixiong Cheng, Ruth Nussinov
The underlying genetic causes and altered signaling pathways of brain arteriovenous malformations remain unknown. A study published in The New England Journal of Medicine reported that KRAS somatic mutations (p.Gly12Val/Asp) were identified in brain arteriovenous malformations of human subjects and endothelial cell-enriched cultures, which might specifically activate the MAPK (mitogen-activated protein kinase)–ERK (extracellular signal-regulated kinase) signaling pathway in brain endothelial cells.



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