Validating the AJCC Eighth Edition Prognostic Stage vs Anatomic Stage in Breast Cancer

To the Editor Weiss et al validated the American Joint Committee on Cancer Eighth Edition prognostic stage and compared it with the anatomic stage in breast cancer in 2 large cohorts. The authors used the Harrell C index to qualify the models' predictive performance based on prognostic stage and anatomic stage, respectively. The authors further determined the significance between the Harrell C index of the prognostic stage and anatomic stage using the R package compareC. In the MD Anderson cohort, the Harrell C indices for the prognostic stage and the anatomic stage are 0.8357 and 0.7370 (P < .001). In the California Cancer Registry, the Harrell C indices for the prognostic stage and the anatomic stage are 0.8426 and 0.8097 (P < .001).

https://ift.tt/2M5DFON