​Synaptic adhesion molecules and excitatory synaptic transmission

Publication date: August 2017
Source:Current Opinion in Neurobiology, Volume 45
Author(s): Seil Jang, Hyejin Lee, Eunjoon Kim
Synaptic adhesion molecules have been extensively studied for their contribution to the regulation of synapse development through trans-synaptic adhesions. However, accumulating evidence increasingly indicates that synaptic adhesion molecules are also involved in the regulation of excitatory synaptic transmission and plasticity, often through direct or close associations with excitatory neurotransmitter receptors. This review summarizes recent results supporting this emerging concept and underlying mechanisms, and addresses its implications.



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