Diversion of complement-mediated killing by Bordetella

Publication date: Available online 14 February 2018
Source:Microbes and Infection
Author(s): Anaïs Thiriard, Dominique Raze, Camille Locht
The complement cascade participates in protection against bacterial infection and pathogens, including Bordetella pertussis, have developed complement-evading strategies. Here we discuss current knowledge on B. pertussis complement evasion strategies and the role of antibody-dependent complement-mediated killing in protection against B. pertussis infection pointing out important knowledge gaps for further research to improve current pertussis vaccines.



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