New ADCY3 Variants Dance in Obesity Etiology

Publication date: Available online 14 February 2018
Source:Trends in Endocrinology & Metabolism
Author(s): Yan Tian, Boqiang Peng, Xianghui Fu
The genetic etiology for obesity-related traits remains elusive. Recent studies link novel ADCY3 variants to obesity and diabetes, and identify an important role of ADCY3-mediated signaling at neuronal primary cilia in the predisposition of obesity. These findings provide new information on obesity etiology and suggest potential anti-obesity therapeutic strategies.



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