Purpose: Stabilization of the transcription factor NRF2 through genomic alterations in KEAP1 and NFE2L2 occurs in a quarter of lung adenocarcinoma (LUAD) and a third of lung squamous (LUSC) patients. In LUAD, KEAP1 loss often co-occurs with STK11 loss and KRAS activating alterations. Despite its prevalence, the impact of NRF activation on tumor progression and patient outcomes is not fully defined. Experimental Design: We model NRF2 activation, STK11 loss and KRAS activation in vivo using novel genetically...
Mon Oct 19, 2020 16:17
Deciphering Vaccines for COVID-19: Where do we stand TODAY? Immunopharmacol Immunotoxicol. 2020 Oct 14;:1-48 Authors: Baviskar T, Raut D, Bhatt LK Abstract Pneumonia of unknown etiology was detected in a few patients in Wuhan City, Hubei Province, China. The causative agent was named as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by the World Health Organisation (WHO). The disease caused by this virus was named as a new...
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Three-dimensional modeling and automatic analysis of the human nasal cavity and paranasal sinuses using the computational fluid dynamics method. Eur Arch Otorhinolaryngol. 2020 Oct 17;: Authors: Tretiakow D, Tesch K, Meyer-Szary J, Markiet K, Skorek A Abstract PURPOSE: The goal of this study was to develop a complete workflow allowing for conducting computational fluid dynamics (CFD) simulation of airflow through the upper airways based on...
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Significance of the middle ear risk index in predicting tympanoplasty success in the elderly. Eur Arch Otorhinolaryngol. 2020 Oct 17;: Authors: Sevil E, Doblan A Abstract PURPOSE: To evaluate the relationship between middle ear risk index (MERI) score and success of tympanoplasty in elderly (≥ 60 years) compared with young patients (18-59 years) and to investigate the prognostic factors affecting the success of tympanoplasty. METHODS:...
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Prognostic nomograms based on immune scores for head-neck squamous cell carcinoma patients. Eur Arch Otorhinolaryngol. 2020 Oct 17;: Authors: Li W, Zhao K, Wang Z Abstract PURPOSE: We aim to develop an immune-score nomograms for predicting overall survival (OS) of patients with HNSCC and assess the association of immune scores with prognosis. METHODS: The data of 530 patients used in this study were retrieved from The Cancer Genome...
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Predictive factors of severity and persistence of oropharyngeal dysphagia in sub-acute stroke. Eur Arch Otorhinolaryngol. 2020 Oct 17;: Authors: De Stefano A, Dispenza F, Kulamarva G, Lamarca G, Faita A, Merico A, Sardanelli G, Gabellone S, Antonaci A Abstract PURPOSE: This study aims to understand the factors contributing to the severity of oropharyngeal dysphagia and its persistence in the sub-acute phase of stroke. METHODS: We retrospectively...
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Is the cochlear implant a successful long-term solution for single-sided deaf and asymmetric hearing-impaired patients? Eur Arch Otorhinolaryngol. 2020 Oct 16;: Authors: Speck I, Challier P, Wesarg T, Jakob TF, Aschendorff A, Hassepass F, Arndt S Abstract PURPOSE: We investigated the long-term results of cochlear implant (CI) recipients with asymmetric hearing loss (AHL) or single-sided deafness (SSD). We focused on wearing behavior, audiometric...
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Gigantic paranasal sinuses osteomas: clinical features, management considerations, and long-term outcomes. Eur Arch Otorhinolaryngol. 2020 Oct 16;: Authors: Giotakis E, Sofokleous V, Delides A, Razou A, Pallis G, Karakasi A, Maragoudakis P Abstract PURPOSE: Paranasal sinus osteomas are slow-growing, benign bony tumours that when larger than 30 mm, they are termed 'gigantic'. Special considerations apply for tumours of this calibre, and their...
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Differences in men and women suffering from CRSwNP and AERD in quality of life. Eur Arch Otorhinolaryngol. 2020 Oct 15;: Authors: Bartosik TJ, Liu DT, Campion NJ, Villazala-Merino S, Janik S, Dahm V, Mueller CA, Vyskocil E, Stanek V, Quint T, Bangert C, Eckl-Dorna J, Schneider S Abstract PURPOSE: While the overall impact of chronic rhinosinusitis (CRS) on patients' health is diverse, many affected individuals have a substantially impaired quality...
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The role of high-resolution Computer Tomography in prediction of the round window membrane visibility and the feasibility of the round window electrode insertion. Eur Arch Otorhinolaryngol. 2020 Oct 14;: Authors: Elzayat S, Soltan I, Talaat M, Fouad YA Abstract OBJECTIVE: The aim of this work is to assess the role of pre-operative high-resolution computerized tomography (HRCT) in prediction of the round window membrane (RWM) visibility and...
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European Laryngological Society position paper on laryngeal dysplasia Part II: diagnosis, treatment, and follow-up. Eur Arch Otorhinolaryngol. 2020 Oct 14;: Authors: Eckel HE, Simo R, Quer M, Odell E, Paleri V, Klussmann JP, Remacle M, Sjögren E, Piazza C Abstract PURPOSE OF REVIEW: To give an overview of the current knowledge regarding the diagnosis, treatment, and follow-up of laryngeal dysplasia (LD) and to highlight the contributions of...
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Comparison of different guidelines for oral cancer. Eur Arch Otorhinolaryngol. 2020 Oct 15;: Authors: Köhler HF, Mehanna H, Shah JP, Sanabria A, Fagan J, Kuriakose MA, Rene Leemans C, O'Sullivan B, Krishnan S, Kowalski LP Abstract BACKGROUND: Guidelines should provide accessible and reliable information for decision-making. Also, they should be translatable to multiple settings, allowing their use in diverse situations. METHODS: We...
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Oxidative stress values of tumor core, edge, and healthy thyroid tissue in thyroid masses. Eur Arch Otorhinolaryngol. 2020 Oct 14;: Authors: Dogan R, Dogan EE, Guler EM, Senturk E, Yenigun A, Celik I, Aksoy F, Ozturan O Abstract PURPOSE: Reactive oxygen radicals play an important role in tumor formation, progression, and invasion. In this study, the aim was to investigate the relationship between the oxidative stress values of tumor core, edge,...
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Coding of consonant-vowel transition in children with central auditory processing disorder: an electrophysiological study. Eur Arch Otorhinolaryngol. 2020 Oct 14;: Authors: Kumar P, Singh NK, Ganapathy MK, Sanju HK, Apeksha K Abstract INTRODUCTION: Acoustic change complex (ACC) is an important tool to investigate the encoding of the acoustic property of speech signals in various populations. However, there is a limited number of research papers...
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European Laryngological Society position paper on laryngeal dysplasia Part I: aetiology and pathological classification. Eur Arch Otorhinolaryngol. 2020 Oct 13;: Authors: Odell E, Eckel HE, Simo R, Quer M, Paleri V, Klussmann JP, Remacle M, Sjögren E, Piazza C Abstract PURPOSE OF REVIEW: To give an overview of the current knowledge regarding the aetiology, epidemiology, and classification of laryngeal dysplasia (LD) and to highlight the contributions...
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Immediate effects of semi-occluded vocal tract exercises in low and high voices: a self-perception study. Codas. 2020;32(5):e20190079 Authors: Martinho DHDC, Constantini AC Abstract PURPOSE: To investigate the self-perception by individuals on the immediate effects of three semi-occluded vocal tract exercises (SOVTE), that is, phonation into a latex tube, finger kazoo and phonation into a high-resistance straw, and to compare the self-perception...
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Exploring the Factor Structure of the Glasgow Children's Benefit Inventory: New Recommendations for Reporting Results. Ann Otol Rhinol Laryngol. 2020 Oct 16;:3489420965634 Authors: Kubba H, Whitmer WM Abstract OBJECTIVE: Patient-reported outcomes can be useful for reporting benefit from non-life-saving interventions, but often they report a single overall score, which means that much information on the specific areas of benefit is lost....
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Vocal Fold Immobility Following Vaccination. Ann Otol Rhinol Laryngol. 2020 Oct 16;:3489420965633 Authors: Talmor G, Nguyen B, Din-Lovinescu C, Paskhover B, Kaye R Abstract OBJECTIVE: Vocal fold immobility (VFI) may severely affect quality of life due to dysphonia and respiratory distress. Many etiologies of this disorder have been evaluated, however the relationship between VFI and vaccination has yet to be explored. The objective of...
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24 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "J Neural Eng"[jour] These pubmed results were generated on 2020/10/19PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Tumors of the paratesticular region are generally tumors of slow growth, with little symptomatology and, in most cases, benign in nature; in this area, a borderline serous tumor may arise hypothetically from Müllerian metaplasia of the tunica vaginalis, which is histologically identical to its ovarian counterpart. We present a 10-year-old male, with right gynecomastia and ipsilateral hydrocele, showing an enlarged right testicle with a volume of 12 ml and a left testicle with a volume of 10 ml. A...
Mon Oct 19, 2020 16:20
Objectives. To review the literature on neo-vallecula diagnosis and management and to report our findings regarding 3 patients who developed neo-vallecula in the context of free-flap pharyngeal reconstruction following total laryngectomy. Methods. This case series reports three patients who developed a neo-vallecula following a laryngectomy and free-flap pharyngeal reconstruction. All three patients were treated with a CO2 laser endoscopic procedure. Results. Neo-vallecula formation is thought to...
Mon Oct 19, 2020 16:05
Plasma Golgi protein 73 levels predict prognosis of HCV-related hepatic fibrosis. Histol Histopathol. 2020 Oct 14;:18269 Authors: Liu L, Al-Dhamin Z, Yuan X, Cui L, Yang Y, Zhao W, Zhang Y, Fu N, Nan Y Abstract OBJECTIVES: To explore the correlation between plasma Golgi protein 73 (GP73) and progression of hepatitis C virus (HCV)-induced hepatic fibrosis. METHODS: A total of 232 subjects of chronic hepatitis C and 31 healthy controls...
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Nasal colonization of Methicillin-resistant Staphylococcus aureus (MRSA) plays a key role in the epidemiology and pathogenesis of both healthcare-associated and community-acquired MRSA infections in various popul...
Mon Oct 19, 2020 03:00
Extracting Signature Responses from Respiratory Flows: Low-dimensional Analyses on DNS-Predicted Wakes of a Flapping Uvula. Int J Numer Method Biomed Eng. 2020 Oct 17;:e3406 Authors: Xi J, Wang J, Si XA, Zheng S, Donepudi R, Dong H Abstract Uvula-induced snoring and associated obstructive sleep apnea (OSA) is a complex phenomenon characterized by vibrating structures and highly transient vortex dynamics. This study aimed to extract signature...
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Evaluation of Upper Airway in Children with Obstructive Sleep Apnea Using Cone-Beam Computed Tomography. Laryngoscope. 2020 Jul 13;: Authors: Hsu WC, Kang KT, Yao CJ, Chou CH, Weng WC, Lee PL, Chen YJ Abstract OBJECTIVE: Cone-beam computed tomography (CBCT) offers three-dimensional structures in assessing upper airway of patients. This study aims to compare the cone-beam computerized tomography scan measurements between children with obstructive...
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Splenic infarction associated with obstructive sleep apnoea/hypopnoea syndrome: a case report. J Int Med Res. 2020 Oct;48(10):300060520954691 Authors: Li Y, Liu H, Shi Y Abstract Splenic infarction is rare, resulting from occlusion of the splenic artery or its branches. Its aetiology is complex and multifactorial involving various vascular and thrombotic diseases, thus, misdiagnosis or missed diagnosis is common. Here, the case of a 45-year...
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An update of venetoclax and obinutuzumab in chronic lymphocytic leukemia. Future Oncol. 2020 Oct 16;: Authors: Salvaris R, Opat S Abstract In the last decade, the treatment of chronic lymphocytic leukemia (CLL) has shifted away from chemoimmunotherapy toward targeted novel agents such as small molecule inhibitors and antibodies. Here, we give an overview of the pharmacology of venetoclax and obinutuzumab and the evidence from early phase to...
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Syt-7 overexpression predicts poor prognosis and promotes cell proliferation in hepatocellular carcinoma. Future Oncol. 2020 Oct 14;: Authors: Jin H, Pang Q, Fang M, Wang Y, Man Z, Tan Y, Liu H Abstract Aim: To explore the prognostic significance of Syt-7 in hepatocellular carcinoma (HCC) and the potential mechanisms. Methods: Immunohistochemistry was used to examine the expression of Syt-7. Overall survival and disease-free survival were compared...
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Next-generation sequencing of circulating tumor DNA for metastatic non-small cell lung cancer: a discussion on its implementation in the Brazilian clinical practice. Future Oncol. 2020 Oct 14;: Authors: H Araujo L, Ferreira CG, Baldotto CS, Mathias C, Castro G, Coudry R Abstract The objective of this review is to address the barriers limiting access to next-generation sequencing (NGS) of circulating tumor DNA (ctDNA) for metastatic nonsquamous...
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Comparative efficacy of cemiplimab versus other systemic treatments for advanced cutaneous squamous cell carcinoma. Future Oncol. 2020 Oct 14;: Authors: Keeping S, Xu Y, Chen CI, Cope S, Mojebi A, Kuznik A, Konidaris G, Ayers D, Sasane M, Allen R, Huynh TM, Popoff E, Freeman M, Andria ML, Fury MG, Singh K, Stockfleth E, Challapalli A, Schmults CD Abstract Aim: To estimate the comparative efficacy of cemiplimab, a programmed cell death protein...
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Can Quantitative MRI Be Used to Differentiate Physiologic Changes Behind Muscle Weakness in Type 2 Diabetes Mellitus? Radiology. 2020 Oct 13;:203768 Authors: Sneag DB, Tan ET PMID: 33064035 [PubMed - as supplied by publisher]
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Mounting Evidence for Synthetic Mammography in Breast Cancer Screening. Radiology. 2020 Oct 13;:203716 Authors: Lång K PMID: 33064034 [PubMed - as supplied by publisher]
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Arterial Transit Awesomeness. Radiology. 2020 Oct 13;:203838 Authors: Zaharchuk G PMID: 33052076 [PubMed - as supplied by publisher]
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Extracting Signature Responses from Respiratory Flows: Low-dimensional Analyses on DNS-Predicted Wakes of a Flapping Uvula. Int J Numer Method Biomed Eng. 2020 Oct 17;:e3406 Authors: Xi J, Wang J, Si XA, Zheng S, Donepudi R, Dong H Abstract Uvula-induced snoring and associated obstructive sleep apnea (OSA) is a complex phenomenon characterized by vibrating structures and highly transient vortex dynamics. This study aimed to extract signature...
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Evaluation of Upper Airway in Children with Obstructive Sleep Apnea Using Cone-Beam Computed Tomography. Laryngoscope. 2020 Jul 13;: Authors: Hsu WC, Kang KT, Yao CJ, Chou CH, Weng WC, Lee PL, Chen YJ Abstract OBJECTIVE: Cone-beam computed tomography (CBCT) offers three-dimensional structures in assessing upper airway of patients. This study aims to compare the cone-beam computerized tomography scan measurements between children with obstructive...
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Prolonged Circulation Time is Associated with Mortality Among Older Men with Sleep Disordered Breathing. Chest. 2020 Oct 15;: Authors: Kwon Y, Sands SA, Stone KL, Taranto-Montemurro L, Alex RM, White DP, Wellman A, Redline S, Azarbarzin A Abstract BACKGROUND: Conventional metrics to evaluate sleep disordered breathing (SDB) have many limitations including their inability to identify subclinical markers of cardiovascular (CV) dysfunction. ...
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The association between sleep pathology and depression: A cross-sectional study among adults in greece. Psychiatry Res. 2020 Oct 08;294:113502 Authors: Vorvolakos T, Leontidou E, Tsiptsios D, Mueller C, Serdari A, Terzoudi A, Nena E, Tsamakis K, Constantinidis TC, Tripsianis G Abstract A cross-sectional population based study was conducted in order to evaluate the potential association of sleep characteristics with depression using self-reported...
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A critical analysis of the purported role of hypoxemia in the comorbidity of obstructive sleep apnea and epilepsy. Clin Physiol Funct Imaging. 2020 Oct 17;: Authors: Mishra P, Jaseja H, Goyal M Abstract Obstructive sleep apnea (OSA) is a globally prevalent sleep disorder of significant health concern and confounded with several comorbidities resulting in adverse effect(s) on quality of life in patients afflicted with it. Of particular interest...
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Augmentation of the posterior pharyngeal wall with autologous tragal cartilage for management of velopharyngeal valve insufficiency in adults. Auris Nasus Larynx. 2020 Oct 13;: Authors: Khafagy AG, Kassamy H, Mohamed AA Abstract OBJECTIVE: The study aims to evaluate posterior pharyngeal wall augmentation using autologous tragal cartilage graft in adults with velopharyngeal valve insufficiency (VPI). METHODS: The study included 23 patients...
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The Impact of Time-Restricted Diet on Sleep and Metabolism in Obese Volunteers. Medicina (Kaunas). 2020 Oct 14;56(10): Authors: Kim H, Jang BJ, Jung AR, Kim J, Ju HJ, Kim YI Abstract Background and objectives: A time-restricted diet is one of the various ways to improve metabolic condition and weight control. However, until now, there have been few pieces of evidence and research to verify the methods and effectiveness of time-restricted diets...
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Assessment of Screening for Nasal Obstruction among Sleep Dentistry Outpatients with Obstructive Sleep Apnea. Dent J (Basel). 2020 Oct 14;8(4): Authors: Sawa A, Suzuki H, Niwa H, Oguchi S, Yagi T, Iwata Y, Makiyama Y, Chow CM, Komiyama O Abstract Oral appliances (OA), a common treatment modality for obstructive sleep apnea (OSA), are not suitable for patients with nasal obstruction. Rhinomanometry, the gold standard technique to assess nasal...
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Ansa Cervicalis Stimulation: A New Direction in Neurostimulation for Obstructive Sleep Apnea. Chest. 2020 Oct 13;: Authors: Kent DT, Zealear D, Schwartz AR Abstract BACKGROUND: Hypoglossal nerve stimulation (HNS) is an alternative treatment option for patients with obstructive sleep apnea (OSA) unable to tolerate positive airway pressure, but implant criteria limit treatment candidacy. Prior research indicates that caudal tracheal traction...
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A Novel Model to Estimate Key OSA Endotypes from Standard Polysomnography and Clinical Data and Their Contribution to OSA Severity. Ann Am Thorac Soc. 2020 Oct 16;: Authors: Dutta R, Delaney G, Toson B, Jordan AS, White DP, Wellman A, Eckert DJ Abstract RATIONALE: There are at least four key pathophysiological endotypes that contribute to obstructive sleep apnea (OSA) pathophysiology. These include: 1) upper-airway collapsibility (Pcrit), 2)...
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Correlation between apnea-hypopnea index and Tp-Te interval, Tp-Te/QT, and Tp-Te/QTc ratios in obstructive sleep apnea. Ann Noninvasive Electrocardiol. 2020 Oct 16;:e12809 Authors: Karacop E, Karacop HB Abstract BACKGROUND: Obstructive sleep apnea (OSA) is a highly prevalent sleep disorder associated with important cardiovascular complications including ventricular arrhythmias. Tp-Te interval, Tp-Te/QT, and Tp-Te/QTc ratios are repolarization...
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Rise in nocturnal respiratory rate during CPAP may be an early sign of COVID-19 in patients with obstructive sleep apnea. J Clin Sleep Med. 2020 Oct 15;16(10):1811-1813 Authors: Nakano H, Kadowaki M, Furukawa T, Yoshida M Abstract None: A middle-aged man with obstructive sleep apnea who had been treated with continuous positive airway pressure developed COVID-19. An analysis of airflow records from the continuous positive airway pressure machine...
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Is idiopathic central sleep apnea a separate entity? J Clin Sleep Med. 2020 Oct 16;: Authors: Diaz S, Brown LK PMID: 33063658 [PubMed - as supplied by publisher]
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Three-Dimensional Printed Ventilators: A Rapid Solution to Coronavirus Disease 2019-Induced Supply-Chain Shortages. Crit Care Explor. 2020 Oct;2(10):e0226 Authors: Nacharaju D, Menzel W, Fontaine E, Child D, El Haddi SJ, Nonas S, Chi A Abstract Objective: To examine rapidly emerging ventilator technologies during coronavirus disease 2019 and highlight the role of CRISIS, a novel 3D printed solution. Data Sources: Published articles,...
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Usefulness of Cathepsin S to Predict Risk for Obstructive Sleep Apnea among Patients with Type 2 Diabetes. Dis Markers. 2020;2020:8819134 Authors: Wen W, Sun H, Yang Y, Jia Y, Fang F, Qin Y, Zhang M, Wei Y Abstract Background: Obstructive sleep apnea (OSA) was highly prevalent in patients with type 2 diabetes (T2D). Cathepsin S (CTSS), a cysteine protease, is involved in the inflammatory activity in T2D and hypoxia conditions. The aim of the...
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Increased Metabolic Burden Among Blacks: A Putative Mechanism for Disparate COVID-19 Outcomes. Diabetes Metab Syndr Obes. 2020;13:3471-3479 Authors: Jean-Louis G, Turner AD, Jin P, Liu M, Boutin-Foster C, McFarlane SI, Seixas A Abstract Mounting evidence shows a disproportionate COVID-19 burden among Blacks. Early findings indicate pre-existing metabolic burden (eg, obesity, hypertension and diabetes) as key drivers of COVID-19 severity. Since...
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Previously Undetected Obstructive Sleep Apnea in Patients with New-Onset Atrial Fibrillation. Am J Cardiol. 2020 Oct 12;: Authors: Bazan V, Vicente I, Lozano L, Villuendas R, González M, Adeliño R, Bisbal F, Sarrias A, Abad J, Sanz-Santos J, Padilla F, Bayés-Genís A Abstract Obstructive sleep apnea-hypopnea syndrome (OSA) compromises the efficacy of atrial fibrillation (AF) control strategies. Continuous positive airway pressure (CPAP) may...
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Blowing Away Fatty Liver: Mission Impossible? Am J Respir Crit Care Med. 2020 Oct 15;: Authors: McLean AEB, Gagnadoux F, Yee BJ PMID: 33058739 [PubMed - as supplied by publisher]
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Predictors of OSA following Adenotonsillectomy in Children with Trisomy 21. Clin Otolaryngol. 2020 Oct 15;: Authors: Raposo D, Menezes M, Rito J, Trindade-Soares M, Adónis C, Loureiro HC, Freire F Abstract OBJECTIVES: Given that 30-50% of children with trisomy 21 have persistent obstructive sleep apnea (OSA) after adenotonsillectomy, we evaluated whether demographic, clinical and polysomnographic factors predicted persistent OSA and OSA severity...
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Proangiogenic factor midkine is increased in melanoma patients with sleep apnea and induces tumor cell proliferation. FASEB J. 2020 Oct 15;: Authors: Cubillos-Zapata C, Martínez-García MÁ, Díaz-García E, Toledano V, Campos-Rodríguez F, Sánchez-de-la-Torre M, Nagore E, Martorell-Calatayud A, Hernández Blasco L, Pastor E, Abad-Capa J, Montserrat JM, Cabriada-Nuño V, Cano-Pumarega I, Corral-Peñafiel J, Arias E, Mediano O, Somoza-González M, Dalmau-Arias J, Almendros...
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Associations between hypoxia parameters in obstructive sleep apnea and cognition, cortical thickness, and white matter integrity in middle-aged and older adults. Sleep Breath. 2020 Oct 14;: Authors: Chokesuwattanaskul A, Chirakalwasan N, Jaimchariyatam N, Pitakvej N, Sarutikriangkri Y, Chunharas C, Phanthumchinda K, Likitjaroen Y Abstract OBJECTIVE: This study aimed to investigate the association between each parameter of intermittent hypoxia...
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Algorithm for automatic detection of self-similarity and prediction of residual central respiratory events during CPAP. Sleep. 2020 Oct 15;: Authors: Oppersma E, Ganglberger W, Sun H, Thomas RJ, Westover MB Abstract STUDY OBJECTIVES: Sleep disordered breathing is a significant risk factor for cardiometabolic and neurodegenerative diseases. High loop gain is a driving mechanism of central sleep apnea or periodic breathing. This study presents...
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Common Methods for Missing Data in Marginal Structural Models: What Works and Why. Am J Epidemiol. 2020 Oct 15;: Authors: Leyrat C, Carpenter JR, Bailly S, Williamson EJ Abstract Marginal structural models (MSMs) are commonly used to estimate causal intervention effects in longitudinal non-randomised studies. A common challenge when using MSMs to analyse observational studies is incomplete confounder data, where a poorly informed analysis method...
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Change of respiratory functions, the STOP-Bang questionnaire, and Epworth sleepiness scale after bariatric surgery. Ann Ital Chir. 2020 Jul 27;9: Authors: Kara S, Habesoglu MA, Yabanoglu H Abstract INTRODUCTION AND OBJECTIVE: Obesity is a highly morbid and fatal syndrome that reduces respiratory function. Obstructive sleep apnea syndrome (OSAS) is a common sleep disorder in morbid obesity. Herein, we aimed to determine how respiratory function...
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Sleep apnea 20/20: a 20-year cohort that continues to inform the next 20 years. J Clin Sleep Med. 2020 Oct 15;: Authors: Patel SI, Combs D, Parthasarathy S PMID: 33054968 [PubMed - as supplied by publisher]
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Up, down, or no change: weight gain as an unwanted side effect of CPAP for obstructive sleep apnea. J Clin Sleep Med. 2020 Oct 15;: Authors: Brown LK PMID: 33054961 [PubMed - as supplied by publisher]
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Cutoff points in STOP-Bang questionnaire for obstructive sleep apnea. Arq Neuropsiquiatr. 2020 Sep;78(9):561-569 Authors: Neves Junior JAS, Fernandes APA, Tardelli MA, Yamashita AM, Moura SMPGT, Tufik S, Silva HCAD Abstract BACKGROUND: Obstructive Sleep Apnea Syndrome (OSAS) is a public health problem of high prevalence and impacts on quality of life, anesthetic complications and cardiovascular diseases. In view of the difficulty in accessing...
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The Pathophysiology of Rett Syndrome With a Focus on Breathing Dysfunctions. Physiology (Bethesda). 2020 Nov 01;35(6):375-390 Authors: Ramirez JM, Karlen-Amarante M, Wang JJ, Bush NE, Carroll MS, Weese-Mayer DE, Huff A Abstract Rett syndrome (RTT), an X-chromosome-linked neurological disorder, is characterized by serious pathophysiology, including breathing and feeding dysfunctions, and alteration of cardiorespiratory coupling, a consequence...
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Segmentation of 4D images via space-time neural networks. Proc SPIE Int Soc Opt Eng. 2020 Feb;11317: Authors: Sun C, Udupa JK, Tong Y, Sin S, Wagshul M, Torigian DA, Arens R Abstract Medical imaging techniques currently produce 4D images that portray the dynamic behaviors and phenomena associated with internal structures. The segmentation of 4D images poses challenges different from those arising in segmenting 3D static images due to different...
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Relationship between sleep efficacy endpoints and measures of functional status and health-related quality of life in participants with narcolepsy or obstructive sleep apnea treated for excessive daytime sleepiness. J Sleep Res. 2020 Oct 13;:e13210 Authors: Weaver TE, Mathias SD, Crosby RD, Bron M, Bujanover S, Menno D, Villa KF, Drake C Abstract This study examined the correlation between improvements in excessive daytime sleepiness in participants...
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Splenic infarction associated with obstructive sleep apnoea/hypopnoea syndrome: a case report. J Int Med Res. 2020 Oct;48(10):300060520954691 Authors: Li Y, Liu H, Shi Y Abstract Splenic infarction is rare, resulting from occlusion of the splenic artery or its branches. Its aetiology is complex and multifactorial involving various vascular and thrombotic diseases, thus, misdiagnosis or missed diagnosis is common. Here, the case of a 45-year...
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Role of the Cyclooxygenase Pathway in the Association of Obstructive Sleep Apnea and Cancer. J Clin Med. 2020 Oct 10;9(10): Authors: Picado C, Roca-Ferrer J Abstract The objective of this review is to examine the findings that link obstructive sleep apnea (OSA) with cancer and the role played by the cyclooxygenase (COX) pathway in this association. Epidemiological studies in humans suggest a link between OSA and increased cancer incidence and...
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Related Articles Sleep quality in times of Covid-19 pandemic. Sleep Med. 2020 10;74:81-85 Authors: Pinto J, van Zeller M, Amorim P, Pimentel A, Dantas P, Eusébio E, Neves A, Pipa J, Santa Clara E, Santiago T, Viana P, Drummond M Abstract BACKGROUND: Due to the 2019 novel coronavirus (COVID-19) disease outbreak, social distancing measures were imposed to control the spread of the pandemic. However, isolation may affect negatively the psychological...
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Related Articles Oral health in children with sleep-disordered breathing: a cross-sectional study. Acta Biomed. 2019 07 10;90(7-S):52-59 Authors: Grillo C, La Mantia I, Zappala G, Cocuzza S, Ciprandi G, Andaloro C Abstract Sleep-disordered breathing (SDB) is associated with a wide range of oral manifestations, including adeno-tonsillar hypertrophy, narrow dentoalveolar width, increased overjet, reduced overbite, and malocclusion. There are...
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FGF13 interaction with SHCBP1 activates AKT-GSK3α/β signaling and promotes the proliferation of A549 cells. Cancer Biol Ther. 2020 Oct 16;:1-11 Authors: Lu H, Yin M, Wang L, Cheng J, Cheng W, An H, Zhang T Abstract FGF13, a member of the FGF subfamily, has been found to be highly expressed in cancer cells such as prostate cancer, melanoma, glioma and multiple myeloma. However, the mechanism of FGF13 function during cancer cell proliferation...
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Metallophosphoesterase 1, a novel candidate gene in hepatocellular carcinoma malignancy and recurrence. Cancer Biol Ther. 2020 Oct 15;:1-9 Authors: Chen X, Xu J, Wang P, Shang L, Guo J, Huang L, Jiang YA, Chen J, Chen H, Shang Y, Zhang Q Abstract BACKGROUND: There is an unmet need to identify novel mechanism-based prognostic genes associated with hepatocellular carcinoma (HCC) recurrence that can predict patient outcomes and provide therapeutic...
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Cyclin E overexpression confers resistance to trastuzumab through noncanonical phosphorylation of SMAD3 in HER2+ breast cancer. Cancer Biol Ther. 2020 Oct 14;:1-11 Authors: Decker JT, Kandagatla P, Wan L, Bernstein R, Ma JA, Shea LD, Jeruss JS Abstract The efficacy of trastuzumab, a treatment for HER2+ breast cancer, can be limited by the development of resistance. Cyclin E (CCNE) overexpression has been implicated in trastuzumab resistance....
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Therapy for acute myelogenous leukemia revisited: moving away from a one-size-fits-all approach. Expert Rev Anticancer Ther. 2020 Oct 16;: Authors: Reikvam H, Hemsing AL, Smith C PMID: 33059507 [PubMed - as supplied by publisher]
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Abemaciclib, a third CDK 4/6 inhibitor for the treatment of hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced or metastatic breast cancer. Expert Rev Anticancer Ther. 2020 Oct 15;: Authors: El Hachem G, Gombos A, Awada A Abstract INTRODUCTION: The field of metastatic luminal breast cancer (hormone receptor positive, HER-2 negative) is dynamic and evolving, harboring some of the most significant therapeutic...
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Metronomic therapy in advanced breast cancer and NSCLC: vinorelbine as a paradigm of recent progress. Expert Rev Anticancer Ther. 2020 Oct 15;: Authors: Xu B, Sun T, Wang S, Lin Y Abstract INTRODUCTION: Metronomic chemotherapy (MCT) is based on frequent dosing of the drug - typically using an oral formulation - at below the maximum tolerated dose. This leads to pharmacologically active but low plasma concentrations that reduce toxicity and...
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Clinical risk factors for mortality in patients with cancer and COVID-19: a systematic review and meta-analysis of recent observational studies. Expert Rev Anticancer Ther. 2020 Oct 14;: Authors: Liu Y, Lu H, Wang W, Liu Q, Zhu C Abstract INTRODUCTION: Patients with cancer are more vulnerable to COVID-19 than the general population. Accordingly, it is necessary to identify the risk factors for death in patients with cancer and COVID-19. ...
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Luteinized thecoma (thecomatosis) with sclerosing peritonitis: a systematic review of the literature of the last 25 years. Expert Rev Anticancer Ther. 2020 Oct 14;: Authors: Muratori L, Trevisi E, Delcuratolo MD, Sperone P, Di Maio M Abstract INTRODUCTION: Luteinized thecoma (thecomatosis) with sclerosing peritonitis (LTSP) is a very uncommon syndrome, characterized by the presence of single or bilateral ovarian thecomas and peritoneal fibrotic...
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Monoclonal antibodies as an addition to current myeloma therapy strategies. Expert Rev Anticancer Ther. 2020 Oct 14;: Authors: Jullien M, Touzeau C, Moreau P Abstract INTRODUCTION: Immunotherapy has emerged as a major class in the therapeutic arsenal of multiple myeloma. Cell-based immunotherapy (CAR T-cells) and monoclonal antibody-based immunotherapy (naked monoclonal antibodies, antibody-drug conjugates and bispecific T-cell engagers) are...
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Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c07192
Mon Oct 19, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c06335
Mon Oct 19, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c06976
Mon Oct 19, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c10615
Mon Oct 19, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c04675
Mon Oct 19, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c07137
Mon Oct 19, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c07784
Mon Oct 19, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08145
Mon Oct 19, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08448
Mon Oct 19, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c07808
Mon Oct 19, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c09505
Mon Oct 19, 2020 07:00
Oropharyngeal squamous cell carcinoma: radiomic machine-learning classifiers from multiparametric MR images for determination of HPV infection status. Sci Rep. 2020 Oct 16;10(1):17525 Authors: Suh CH, Lee KH, Choi YJ, Chung SR, Baek JH, Lee JH, Yun J, Ham S, Kim N Abstract We investigated the ability of machine-learning classifiers on radiomics from pre-treatment multiparametric magnetic resonance imaging (MRI) to accurately predict human papillomavirus...
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A hyperactive RelA/p65-hexokinase 2 signaling axis drives primary central nervous system lymphoma. Cancer Res. 2020 Oct 16;: Authors: Tateishi K, Miyake Y, Kawazu M, Sasaki N, Nakamura T, Sasame J, Yoshii Y, Ueno T, Miyake A, Watanabe J, Matsushita Y, Shiba N, Udaka N, Ohki K, Fink AL, Tummala SS, Natsumeda M, Ikegaya N, Nishi M, Ohtake M, Miyazaki R, Suenaga J, Murata H, Aoki I, Miller JJ, Fujii Y, Ryo A, Yamanaka S, Mano H, Cahill DP, Wakimoto H, Chi AS, Batchelor...
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Development and validation of a survival model for thyroid carcinoma based on autophagy-associated genes. Aging (Albany NY). 2020 Oct 14;12: Authors: Han B, Yang X, Hosseini DK, Luo P, Liu M, Xu X, Zhang Y, Su H, Zhou T, Sun H, Chen X Abstract Abnormalities in autophagy-related genes (ARGs) are closely related to the occurrence and development of thyroid carcinoma (THCA). However, the effect of ARGs on the prognosis of THCA remains unclear....
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A Narrative Review of Regional Hyperthermia: Updates From 2010 to 2019. Integr Cancer Ther. 2020 Jan-Dec;19:1534735420932648 Authors: Fiorentini G, Sarti D, Gadaleta CD, Ballerini M, Fiorentini C, Garfagno T, Ranieri G, Guadagni S Abstract The role of hyperthermia (HT) in cancer therapy and palliative care has been discussed for years in the literature. There are plenty of articles that show good feasibility of HT and its efficacy in terms...
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ARTSCAN III: A Randomized Phase III Study Comparing Chemoradiotherapy With Cisplatin Versus Cetuximab in Patients With Locoregionally Advanced Head and Neck Squamous Cell Cancer. J Clin Oncol. 2020 Oct 14;:JCO2002072 Authors: Gebre-Medhin M, Brun E, Engström P, Haugen Cange H, Hammarstedt-Nordenvall L, Reizenstein J, Nyman J, Abel E, Friesland S, Sjödin H, Carlsson H, Söderkvist K, Thomasson M, Zackrisson B, Nilsson P Abstract PURPOSE: We performed...
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Related Articles Development and validation of a preclinical model for training and assessment of cerebrospinal fluid leak repair in endoscopic skull base surgery. Int Forum Allergy Rhinol. 2020 01;10(1):89-96 Authors: Mattavelli D, Ferrari M, Rampinelli V, Schreiber A, Buffoli B, Deganello A, Rodella LF, Fontanella MM, Nicolai P, Doglietto F Abstract BACKGROUND: Achieving an effective endoscopic skull base reconstruction in case of large dural...
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Telomerase Reverse Transcriptase Protein Expression Is More Frequent in Acral Lentiginous Melanoma Than in Other Types of Cutaneous Melanoma. Arch Pathol Lab Med. 2020 Oct 14;: Authors: Cho WC, Wang WL, Milton DR, Ingram DR, Nagarajan P, Curry JL, Ivan D, Lazar AJ, Hwu WJ, Prieto VG, Torres-Cabala CA, Aung PP Abstract CONTEXT.—: Molecularly distinct from cutaneous melanomas arising from sun-exposed sites, acral lentiginous melanomas (ALMs)...
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Current Status of Clinical Application of Point-of-Care Testing. Arch Pathol Lab Med. 2020 Oct 14;: Authors: Park HD Abstract CONTEXT.—: The clinical applications of point-of-care testing (POCT) are gradually increasing in many health care systems. Recently, POCT devices using molecular genetic method techniques have been developed. We need to examine clinical pathways to see where POCT can be applied to improve them. OBJECTIVE.—:...
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Evaluating Estrogen Receptor Immunohistochemistry on Cell Blocks From Breast Cancer Patients in a Low-Resource Setting. Arch Pathol Lab Med. 2020 Oct 14;: Authors: Kimambo AH, Vuhahula EA, Mwakigonja AR, Ljung BM, Zhang L, Van Loon K, Ng DL Abstract CONTEXT.—: Breast cancer biomarker assessment is critical in determining treatment and prognosis. In Tanzania, immunohistochemistry (IHC) is limited to surgical specimens and core biopsies. However,...
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Background. Head and neck squamous cell carcinoma (HNSCC) is one of the most common malignancies in the world, with low survival and poor quality of life. Autophagy-associated genes (ATGs) have been reported to be involved in the initiation and progression of malignancies. Here, we aimed to investigate the association between autophagy-associated genes and the outcomes in HNSCC patients. Methods. We obtained ATGs with prognostic values by analyzing the datasets from The Cancer Genome Atlas (TCGA)...
Mon Oct 19, 2020 17:35
Objective. Inflammation-driven markers play a crucial role in tumorigenesis and tumor progression. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in blood are systemic inflammatory response markers. Some reports have showed that NLR and PLR are related to a poor prognosis in patients with lung cancer. However, little studies have reported whether NLR and PLR can be diagnostic markers for lung cancer. The aim of the current study is to investigate the roles of NLR...
Mon Oct 19, 2020 17:20
1406 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: upper respiratory tract infection These pubmed results were generated on 2020/10/19PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Computed tomographic analysis of the prevalence of International Frontal Sinus Anatomy Classification cells and their association with frontal sinusitis. J Laryngol Otol. 2020 Oct 14;:1-8 Authors: Seth N, Kumar J, Garg A, Singh I, Meher R Abstract OBJECTIVES: To determine the radiological prevalence of frontal cells according to the International Frontal Sinus Anatomy Classification in patients undergoing computed tomography of the paranasal...
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Detection of Usutu virus infection in wild birds in the United Kingdom, 2020. Euro Surveill. 2020 Oct;25(41): Authors: Folly AJ, Lawson B, Lean FZ, McCracken F, Spiro S, John SK, Heaver JP, Seilern-Moy K, Masters N, Hernández-Triana LM, Phipps LP, Nuñez A, Fooks AR, Cunningham AA, Johnson N, McElhinney LM Abstract In August 2020, as part of a long-term disease surveillance programme, Usutu virus was detected in five Eurasian blackbirds (Turdus...
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Molecular epidemiological typing of Neisseria gonorrhoeae isolates identifies a novel association between genogroup G10557 (G7072) and decreased susceptibility to cefixime, Germany, 2014 to 2017. Euro Surveill. 2020 Oct;25(41): Authors: Banhart S, Jansen K, Buder S, Tamminga T, Calvignac-Spencer S, Pilz T, Martini A, Dudareva S, Nikisins S, Dehmel K, Zuelsdorf G, Guhl E, Graeber I, Kohl PK, Unemo M, Bremer V, Heuer D, GORENET study group Abstract ...
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Detection and discrimination of influenza B Victoria lineage deletion variant viruses by real-time RT-PCR. Euro Surveill. 2020 Oct;25(41): Authors: Shu B, Kirby MK, Warnes C, Sessions WM, Davis WG, Liu J, Wilson MM, Lindstrom S, Wentworth DE, Barnes JR Abstract BackgroundDuring the 2016/17 influenza season, influenza B/VIC lineage variant viruses emerged with two (K162N163) or three (K162N163D164) amino acid (aa) deletions in the haemagglutinin...
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Job vacancies at the European Centre for Disease Prevention and Control (ECDC). Euro Surveill. 2020 Oct;25(41): Authors: Eurosurveillance editorial team PMID: 33063653 [PubMed - in process]
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