Brain metastases from Truncal and extremity bone and soft tissue sarcoma: Single institution study of oncologic outcomes. Rare Tumors. 2020;12:2036361320960060 Authors: Chan CM, Lindsay AD, Spiguel AR, Scarborough MT, Gibbs CP Abstract Brain metastases are a rare occurrence in patients with sarcoma. The prognosis for patients is poor, and treatment can contribute to considerable morbidity. We sought to examine the experience of our institution...
07:18
Evaluation of the Electroglottographic Signal Variability in Organic and Functional Dysphonia. J Voice. 2020 Oct 12;: Authors: Nacci A, Macerata A, Bastiani L, Paludetti G, Galli J, Marchese MR, Barillari MR, Barillari U, Laschi C, Cianchetti M, Manti M, Berrettini S, Fattori B, Ursino F Abstract OBJECTIVES: To confirm the data reported in our previous studies on the analysis of the variability of the electroglottographic signal in the pathological...
06:39
Abstract Emerging hepatocellular carcinoma (HCC) has been sequentially reported in chronic hepatitis C virus (HCV) treated with direct‐acting antivirals (DAAs). Homeobox transcript antisense RNA (HOTAIR), an oncogene, has been reported to be associated with cancer. We investigated the predictive value of lnc‐HOTAIR for HCC surveillance in chronic HCV patients following DAAs therapy. The expression levels of lnc‐HOTAIR and ATG‐7 genes were measured in 220 with chronic HCV, following a DAAs based...
Mon Oct 19, 2020 17:54
Species may persist through the unprecedented changes in global conditions using genetic adaptation or physiological plasticity. However, few empirical studies have revealed the relationship between adaptation and plasticity or addressed the long-standing debate on whether plasticity impedes or facilitates adaptive evolution. Here, we used experimental evolution and reciprocal transplantation of the marine coastal copepod, Acartia tonsa, to present-day and future greenhouse conditions (high temperature,...
Mon Oct 19, 2020 03:00
By altering gene expression and creating paralogs, genomic amplifications represent a key component of short-term adaptive processes. In insects, the use of insecticides can select gene amplifications causing an increased expression of detoxification enzymes, supporting the usefulness of these DNA markers for monitoring the dynamics of resistance alleles in the field. In this context, the present study aims to characterise a genomic amplification event associated with resistance to organophosphate...
Mon Oct 19, 2020 03:00
Vertebrates evolved mechanisms for sodium conservation and gas exchange in conjunction with migration from aquatic to terrestrial habitats. Epithelial Na+ channel (ENaC) function is critical to systems responsible for extracellular fluid homeostasis and gas exchange. ENaC is activated by cleavage at multiple specific extracellular polybasic sites, releasing inhibitory tracts from the channel's and {gamma} subunits. We found that proximal and distal polybasic tracts in ENaC subunits coevolved, consistent...
Mon Oct 19, 2020 03:00
The success of antimicrobial treatment is threatened by the evolution of drug resistance. Population genetic models are an important tool in mitigating that threat. However, most such models consider resistance emergence via a single mutational step. Here, we assembled experimental evidence that drug resistance evolution follows two patterns: i) a single mutation, which provides a large MIC increase, or ii) multiple mutations, each conferring a small increase, which combine to yield high-level resistance....
Mon Oct 19, 2020 03:00
Coronaviruses are highly pathogenic and therefore important human and veterinary pathogens viruses worldwide. Members of family Coronaviridae have previously been analysed phylogenetically, resulting in proposals of virus interrelationships. However, available Coronavirus phylogenies remain unrooted, based on limited sampling, and normally depend on a single method. The main subjects of this study are the taxonomy and systematics of coronaviruses and our goal is to build the first natural classification...
Mon Oct 19, 2020 03:00
In 1995, Pleijel raised an issue on the coding of complex (multistate) characters: to find a unique coding approach satisfying both informational and semantical criteria. Following Pleijel's work, this study aims to propose a new answer to this problematic. We proposed here to use hierarchical characters instead of classical partitional ones as hierarchy allows to deal effectively with the different uncertainties met by phylogeneticists since the beginning of phylogenetic data matrices: missing data,...
Mon Oct 19, 2020 03:00
The study of South American camelids and their domestication is a highly debated topic in zooarchaeology. Identifying domestic species (alpaca and llama) in archaeological sites based on morphometry is challenging because of similarity with respect to their wild ancestors. In this study, we generated mitogenomes for 61 ancient camelids dated between 3,500 - 2,400 years BP (Early Formative period) from two archaeological sites in Northern Chile (Tulan 54 and 85), as well as 66 modern camelid mitogenomes...
Mon Oct 19, 2020 03:00
The effectiveness of selection varies among species. It is often estimated by means of an "effective population size" based on neutral polymorphism, but this is confounded in complex ways with demography. The strength of codon bias more directly pertains to how well adaptation at many sites can be maintained in the face of deleterious mutations, but past metrics that compare codon bias across species are confounded by among-species variation in %GC content and/or amino acid composition. Here we propose...
Mon Oct 19, 2020 03:00
Tissue Engineering Part A, Ahead of Print.
Mon Oct 19, 2020 10:00
Tissue Engineering Part A, Ahead of Print.
Mon Oct 19, 2020 10:00
Tissue Engineering Part A, Ahead of Print.
Mon Oct 19, 2020 10:00
Journal of Neurotrauma, Ahead of Print.
Mon Oct 19, 2020 10:00
Journal of Neurotrauma, Ahead of Print.
Mon Oct 19, 2020 10:00
Journal of Neurotrauma, Ahead of Print.
Mon Oct 19, 2020 10:00
Journal of Neurotrauma, Ahead of Print.
Mon Oct 19, 2020 10:00
Journal of Neurotrauma, Ahead of Print.
Mon Oct 19, 2020 10:00
In Vivo Detection of Extracellular Adenosine Triphosphate in a Mouse Model of Traumatic Brain Injury
Journal of Neurotrauma, Ahead of Print.
Mon Oct 19, 2020 10:00
Journal of Neurotrauma, Ahead of Print.
Mon Oct 19, 2020 10:00
Journal of Neurotrauma, Ahead of Print.
Mon Oct 19, 2020 10:00
Through its ability to open pores in cell membranes, perforin-1 plays a key role in the immune system. Consistent with this role, the gene encoding perforin shows hallmarks of complex evolutionary events, incl...
Mon Oct 19, 2020 03:00
Divergent genes in gerbils: prevalence, relation to GC-biased substitution, and phenotypic relevance
Two gerbil species, sand rat (Psammomys obesus) and Mongolian jird (Meriones unguiculatus), can become obese and show signs of metabolic dysregulation when maintained on standard laboratory diets. The genetic bas...
Mon Oct 19, 2020 03:00
Pre-emptive epidural analgesia for acute and chronic post-thoracotomy pain in adults: a systematic review and meta-analysis. Reg Anesth Pain Med. 2020 Oct 14;: Authors: Park SK, Yoon S, Kim BR, Choe SH, Bahk JH, Seo JH Abstract BACKGROUND AND OBJECTIVES: Epidural analgesia is the gold standard for post-thoracotomy pain management and can be started before or after surgical incision. This systematic review and meta-analysis investigated...
06:06
Regional anesthesia for scapular fracture surgery: an educational review of anatomy and techniques. Reg Anesth Pain Med. 2020 Oct 13;: Authors: Sonawane K, Balavenkatasubramanian J, Dixit H, Tayi H, Goel VK Abstract Scapular fractures are very rare, and those requiring surgical interventions are even rarer. Most scapula surgeries are done under general anesthesia with or without the regional anesthesia (RA) technique as an adjunct. Since...
06:06
Ethmoid Sinus Mucosal and Lacrimal Sac Flap Anastomosing in Patients With Failed Dacryocystorhinostomy. J Craniofac Surg. 2020 Oct 12;: Authors: Yu B, Xia Y, Ji Y, Tu Y, Wu W Abstract PURPOSE: The aim of this work is to demonstrate the outcomes of endonasal dacryocystorhinostomy (En-DCR) with anterior ethmoid sinus mucosal and posterior lacrimal sac flap anastomosing in patients with previous failed DCR. METHODS: The clinical data...
06:02
Complications Associated with Lumbar Drain Placement for Endovascular Aortic Repair. J Vasc Surg. 2020 Oct 11;: Authors: Plotkin A, Han SM, Weaver FA, Rowe VL, Ziegler KR, Fleischman F, Mack WJ, Hendrix JA, Magee GA Abstract OBJECTIVES: To review complications associated with perioperative lumbar drain (LD) placement for endovascular aortic repair. METHODS: Patients who had perioperative lumbar drain placement for endovascular repair...
06:02
Spontaneous Intracranial Hypotension. Dtsch Arztebl Int. 2020 Jul 06;117(27-28): Authors: Urbach H, Fung C, Dovi-Akue P, Lützen N, Beck J Abstract BACKGROUND: Spontaneous intracranial hypotension (SIH) is an underdiagnosed disease. Its incidence is estimated at 5 per 100 000 persons per year. METHODS: This review is based on a selective literature search in PubMed covering the years 2000-2019, as well as on the authors' personal experience....
06:02
Related Articles Endoscopic prelacrimal approach to lateral recess of sphenoid sinus: feasibility study. Int Forum Allergy Rhinol. 2020 01;10(1):103-109 Authors: Li L, London NR, Prevedello DM, Carrau RL Abstract BACKGROUND: Various pathologies, including cerebrospinal fluid leaks and meningoencephaloceles, may arise in the lateral recess of the sphenoid sinus (LRSS), which may be accessed via an endonasal transpterygoid approach. The objective...
06:02
There were two intensive care unit (ICU) physician teams and countless nurses and respiratory therapists outside Mr. K.’s room when I arrived on the unit. The attending intensivist filled me in. "He’s maxed out on ECMO and pressors. He has a tension pneumothorax. My fellow is about to do a needle…
Wed Oct 14, 2020 03:00
Strategies to maximize clinical efficiency while maintaining patient safety during the COVID-19 pandemic: an interview-based study from private practice dermatologists. J Dermatolog Treat. 2020 Oct 15;:1-10 Authors: Yim KM, Yim RM, Gaspard S, MacDougall J, Armstrong AW Abstract BACKGROUND: Many dermatologists have experienced significant changes to their practices due to the COVID-19 pandemic. OBJECTIVE: It is vital to recognize how...
05:58
Subtotal Petrosectomy With Preservation of Chorda Tympani for Petrous Bone Cholesteatoma: Case Report. Ear Nose Throat J. 2020 Oct 16;:145561320964268 Authors: Takata Y, Anzai T, Matsumoto F, Hara S, Ikeda K Abstract A petrous bone cholesteatoma (PBC) is a rare epidermoid cyst of the petrous portion of the temporal bone. The main treatment is subtotal petrosectomy (SP), which generally involves sacrificing the chorda tympani. We report...
05:57
Collet-Sicard Syndrome After Jefferson Fracture. Ear Nose Throat J. 2020 Oct 16;:145561320967331 Authors: Shahrvini B, Crawford K, Vahabzadeh-Hagh AM PMID: 33064020 [PubMed - as supplied by publisher]
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Eosinophilic Angiocentric Fibrosis Invading the Nasal Septum: A Case Report and Review of Literature. Ear Nose Throat J. 2020 Oct 16;:145561320964266 Authors: Han SC, Park JH, Hong SN Abstract Eosinophilic angiocentric fibrosis (EAF) is a rare and slowly progressive disease, which usually involves the sino-nasal structures and upper respiratory tract. It is a fibroinflammatory lesion with an unclear etiology. Recent literature suggests...
05:57
Factors Predictive of Outcome in Inferior Turbinate Surgery. Ear Nose Throat J. 2020 Oct 16;:145561320966066 Authors: Harju T, Numminen J Abstract OBJECTIVES: The purpose of the study was to examine the various preoperative predictive factors of inferior turbinate surgery and to find possible factors that predict an optimal subjective response using 3 common surgical techniques-radiofrequency ablation (RFA), diode laser, and microdebrider-assisted...
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Assessment of SARS-CoV-2 in the Cerumen of COVID-19-Positive Patients. Ear Nose Throat J. 2020 Oct 15;:145561320966067 Authors: Islamoglu Y, Bercin S, Aydogan S, Sener A, Tanriverdi F, Gunaydin GP, Dinc B Abstract OBJECTIVE: To evaluate the presence of SARS-CoV-2 virus in the cerumen of patients with COVID-19. METHODS: A prospective study was conducted in a tertiary care pandemic hospital. Sixty COVID-19 patients with cerumen...
05:57
Chemotherapeutic effects of MEK kinase inhibitor and BRAF kinase inhibitor on KRAS-mutated human colon cancer cell lines with different microsatellite instability. J Chemother. 2020 Oct 14;:1-8 Authors: Kim KO, Park WJ, Jung Y, Lee WS Abstract We analyzed responsiveness of KRAS-mutated CRC cell lines with distinctive MSI status against mitogen-activated protein kinase (MEK) inhibitor (selumetinib; AZD) and/or B-raf proto-oncogene (BRAF) kinase...
05:56
The PNPLA3-I148M variant confers an antiatherogenic lipid profile in insulin-resistant patients. J Clin Endocrinol Metab. 2020 Oct 16;: Authors: Luukkonen PK, Qadri S, Lehtimäki TE, Juuti A, Sammalkorpi H, Penttilä AK, Hakkarainen A, Orho-Melander M, Arola J, Yki-Järvinen H Abstract CONTEXT: The I148M (rs738409-G) variant in PNPLA3 increases liver fat content but may be protective against cardiovascular disease. Insulin resistance (IR) amplifies...
05:56
Serum testosterone is inversely, and sex hormone-binding globulin directly, associated with all-cause mortality in men. J Clin Endocrinol Metab. 2020 Oct 16;: Authors: Yeap BB, Marriott RJ, Antonio L, Chan YX, Raj S, Dwivedi G, Reid CM, Anawalt BD, Bhasin S, Dobs AS, Hankey GJ, Matsumoto AM, Norman PE, O'Neill TW, Ohlsson C, Orwoll ES, Vanderschueren D, Wittert GA, Wu FCW, Murray K Abstract CONTEXT: Serum testosterone concentrations decline...
05:56
Treatment of gestational diabetes mellitus and offspring early childhood growth. J Clin Endocrinol Metab. 2020 Oct 15;: Authors: Feghali M, Atlass J, Abebe KZ, Comer D, Catov J, Caritis S, Arslanian S, Scifres C Abstract BACKGROUND: Gestational diabetes mellitus (GDM) is associated with fetal overgrowth and certain treatments are associated with an increased risk of macrosomia. However, there is limited data about the long-term effect of GDM...
05:56
Metabolomics of lean/overweight insulin resistant females reveals alterations in steroids and fatty acids. J Clin Endocrinol Metab. 2020 Oct 14;: Authors: Diboun I, Al-Mansoori L, Al-Jaber H, Albagha O, Elrayess MA Abstract BACKGROUND: The global diabetes epidemic is largely attributed to obesity-triggered metabolic syndrome. However, the impact of insulin resistance (IR) prior to obesity on the high prevalence of diabetes and the molecular...
05:56
Glycemic Control and Variability of Diabetes Secondary to Total Pancreatectomy Assessed by Continuous Glucose Monitoring. J Clin Endocrinol Metab. 2020 Oct 14;: Authors: Juel CTB, Dejgaard TF, Hansen CP, Storkholm JH, Vilsbøll T, Lund A, Knop FK Abstract CONTEXT: The extent of the glycemic variability in diabetes secondary to total pancreatectomy is not fully understood. OBJECTIVE: To evaluate glycemic variability in totally pancreatectomized...
05:56
Roux-en-Y gastric bypass versus sleeve gastrectomy for remission of type 2 diabetes. J Clin Endocrinol Metab. 2020 Oct 14;: Authors: Castellana M, Procino F, Biacchi E, Zupo R, Lampignano L, Castellana F, Sardone R, Palermo A, Cesareo R, Trimboli P, Giannelli G Abstract CONTEXT: Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) are the bariatric procedures most commonly used for the management of obesity. Whether one or the other...
05:56
Dietary fiber, genetic variations of gut microbiota-derived short-chain fatty acids, and bone health in UK biobank. J Clin Endocrinol Metab. 2020 Oct 14;: Authors: Zhou T, Wang M, Ma H, Li X, Heianza Y, Qi L Abstract CONTEXT: Dietary fiber intake may relate to bone health. OBJECTIVE: To investigate whether dietary fiber intake is associated with bone mineral density (BMD), and the modification effect of genetic variations related to...
05:56
Genotype-phenotype features of germline variants of the TMEM127 pheochromocytoma susceptibility gene: a ten-year update. J Clin Endocrinol Metab. 2020 Oct 14;: Authors: Armaiz-Pena G, Flores SK, Cheng ZM, Zhang X, Esquivel E, Poullard N, Vaidyanathan A, Liu Q, Michalek J, Santillan-Gomez AA, Liss M, Ahmadi S, Katselnik D, Maldonado E, Agosto Salgado S, Jimenez C, Fishbein L, Hamidi O, Else T, Lechan R, Tischler A, Benn DE, Dwight T, Clifton-Bligh R, Sanso G,...
05:56
Time-of-day and meal size effects on clinical lipid markers. J Clin Endocrinol Metab. 2020 Oct 14;: Authors: Grant LK, Czeisler CA, Lockley SW, Rahman SA Abstract CONTEXT: Dyslipidemia and cardiovascular disease are common in shift workers and eating at night may contribute to this pathophysiology. OBJECTIVE: To examine the effects of eating at different times of day on lipid profiles. DESIGN: Two 24-hour baseline days with...
05:56
Historical anatomy of hepatic segmentation: about 250 livers corrosions by Rapp (1953) and Couinaud (1953) in the Conservatory of Anatomy in Montpellier. Surg Radiol Anat. 2020 Oct 17;: Authors: Bonnel F, Duparc F Abstract Two "surgeons-anatomists" Rapp in Montpellier and Couinaud in Paris at the same period (1953) given precise anatomy useful for the hepatic surgery and to the tremendous upheavals of radiological investigations. Actually,...
05:52
Persistent primitive olfactory artery without a hairpin turn. Surg Radiol Anat. 2020 Oct 15;: Authors: Uchino A, Ohno H, Ogiichi T Abstract Persistent primitive olfactory artery (POA) is a relatively rare variation of the proximal anterior cerebral artery (ACA) that generally follows an extreme anteroinferior course and takes a hairpin turn before continuing to the A2 segment of the ACA. There are other extremely rare variations, such...
05:52
[Diagnosis and treatment of external otitis]. HNO. 2020 Oct 16;: Authors: Simon F Abstract External otitis is one of the most common infections in the head and neck region, as about 10% of all people suffer from it at least once during their life. It is an infection of the cutis and subcutis of the outer ear canal caused by bacteria, viruses, and fungus as well as allergens or degenerative toxic substances. A concomitant infection of the...
05:39
[Subjective significance of olfactory dysfunction after laryngectomy : Let's ask our patients]. HNO. 2020 Oct 14;: Authors: Steinau P, Walter S, Hübner J, Büntzel J Abstract BACKGROUND AND OBJECTIVE: Laryngectomy is usually associated with olfactory dysfunction. How do laryngectomees personally experience and feel about this change? MATERIALS AND METHODS: In cooperation with the Bundesverband der Kehlkopfoperierten (German Association...
05:39
Recent advances in high-throughput flow cytometry for drug discovery. Expert Opin Drug Discov. 2020 Oct 15;:1-15 Authors: Ding M, Baker D Abstract INTRODUCTION: High-throughput flow cytometry (HTFC) has proven to be an important technology in drug discovery. The use of HTFC enables multi-parametric screening of suspension cells containing heterogenous cell populations and coated particles for screening proteins of interest. Novel targets, novel...
05:36
The beneficial effects of antioxidants combination on cardiac injury induced by tetrachloromethane. Drug Chem Toxicol. 2020 Oct 15;:1-9 Authors: Alshanwani AR, Faddah LM, Hagar H, Alhusaini AM, Shaheen S, Mohammad RA, Alharbi FMB, AlHarthii A, Badr AM Abstract The purpose of this research was to evaluate the efficacy of carsil (CAR) either alone or in combination with α-tocopherol (α-TOCO) and/or turmeric (TUMR) against tetrachloromethane (TCM)-induced...
05:36
In-vivo and in-silico toxicity studies of daidzein: an isoflavone from soy. Drug Chem Toxicol. 2020 Oct 15;:1-9 Authors: Laddha AP, Murugesan S, Kulkarni YA Abstract Daidzein is a naturally occurring compound belonging to the class isoflavones and found in soya beans and other legumes. Acute oral toxicity was performed as per OECD guideline (TG 423) with slight modifications. A repeated dose toxicity study was carried out as per OECD guideline...
05:36
Hot-processed virgin coconut oil abrogates cisplatin-induced nephrotoxicity by restoring redox balance in rats compared to fermentation-processed virgin coconut oil. Drug Chem Toxicol. 2020 Oct 15;:1-10 Authors: Narayanankutty A, Illam SP, Rao V, Shehabudheen S, Raghavamenon AC Abstract Virgin coconut oil (VCO) is a functional food oil prepared from fresh coconut kernel either by hot-processed (HPVCO) or fermentation-processed (FPVCO). The...
05:36
Hypericin, a medicinal compound from St. John's Wort, inhibits genotoxicity induced by mutagenic agents in V79 cells. Drug Chem Toxicol. 2020 Oct 13;:1-6 Authors: de Souza LM, de Sousa FD, Cruz RCR, Tavares DC, Francielli de Oliveira P Abstract This study evaluated the cytotoxic, genotoxic, and the modulatory effects on DNA damage of hypericin in Chinese hamster lung fibroblasts (V79 cells). The hypericin is a natural polycyclic quinone, mainly...
05:36
Radical resection and improvised manubriosternal reconstruction technique for solitary manubriosternal metastasis from papillary thyroid cancer. Int J Surg Case Rep. 2020 Oct 07;76:278-281 Authors: Chaudhry IUH, Cheema A, Aqeel C, Abbas A Abstract INTRODUCTION: Thyroid papillary carcinoma rarely present as manubriosternum metastasis. The standard treatment for patients with metastatic disease is iodine ablation therapy. A surgical resection...
05:35
Absorption, translocation, and effects of Bt Cry1Ac peptides from transgenic cotton to the intercrops and soil functional bacteria. Sci Rep. 2020 Oct 14;10(1):17294 Authors: Zhang W, Cao Z, Wang M, Chen X, Wang B Abstract Insecticidal proteins encoded by the truncated genes from Bacillus thuringiensis (Bt) in transgenic crops are released into soil mainly through root exudate and crop residues. In the present study, Bt Cry1Ac protein was...
05:35
A cutoff thyroglobulin value suggestive of distant metastases in differentiated thyroid cancer patients. Braz J Med Biol Res. 2020;53(11):e9781 Authors: Couto JS, Almeida MFO, Trindade VCG, Marone MMS, Scalissi NM, Cury AN, Ferraz C, Padovani RP Abstract Serum thyroglobulin is used as part of the early postoperative assessment of differentiated thyroid cancer (DTC) since there is a clear relationship between an increased risk of recurrence...
05:35
High-Yield Synthesis of Pyridyl Conjugated Microporous Polymer Networks with Large Surface Areas: From Molecular Iodine Capture to Metal-Free Heterogeneous Catalysis. Macromol Rapid Commun. 2020 Oct 13;:e2000489 Authors: Zuo H, Lyu W, Zhang W, Li Y, Liao Y Abstract Capturing volatile radioactive nuclides including iodine (I129 or I131 ) is one of the major problems to be solved for environmental sustainability. Multiple types of functional...
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[125Ⅰ seed brachytherapy for recurrent salivary gland carcinoma after external radiotherapy]. Beijing Da Xue Xue Bao Yi Xue Ban. 2020 Oct 18;52(5):919-923 Authors: Yu HB, Wu WJ, Lv XM, Shi Y, Zheng L, Zhang JG Abstract OBJECTIVE: To investigate the clinical application and efficacy of 125Ⅰ radioactive seeds implantation in the treatment of recurrent salivary gland carcinoma after external radiotherapy. METHODS: From July 2004...
05:35
Through its ability to open pores in cell membranes, perforin-1 plays a key role in the immune system. Consistent with this role, the gene encoding perforin shows hallmarks of complex evolutionary events, incl...
Mon Oct 19, 2020 03:00
Divergent genes in gerbils: prevalence, relation to GC-biased substitution, and phenotypic relevance
Two gerbil species, sand rat (Psammomys obesus) and Mongolian jird (Meriones unguiculatus), can become obese and show signs of metabolic dysregulation when maintained on standard laboratory diets. The genetic bas...
Mon Oct 19, 2020 03:00
Vocal Indicators of Size, Shape and Body Composition in Polish Men. J Voice. 2020 Oct 14;: Authors: Pawelec ŁP, Graja K, Lipowicz A Abstract OBJECTIVES: From a human evolution perspective, identifying a link between physique and vocal quality could demonstrate dual signaling in terms of the health and biological condition of an individual. In this regard, this study investigates the relationship between men's body size, shape, and composition,...
05:30
Prevalence of p-16 Positive Laryngeal and Pharyngeal Tumors in Nepalese Population: A Hospital based Cross-sectional Study. JNMA J Nepal Med Assoc. 2020 Sep 27;58(229):681-685 Authors: Gyawali BR, Acharya K, Sapkota R, Baskota DK, Sinha BK Abstract INTRODUCTION: P16 overexpression is considered as a good prognostic marker for oropharyngeal squamous cell carcinoma. However, there are very few literatures on the prevalence and outcomes of p16...
05:30
Efficacy of polyglycolic acid sheets and fibrin glue for the prevention of post-ELPS bleeding. Auris Nasus Larynx. 2020 Oct 13;: Authors: Sugimoto S, Fuke T, Kobayashi D, Ueda K, Sawa M, Kaneko M, Fukukita K, Temma T, Nomura T, Fuwa N, Yamada H Abstract OBJECTIVE: To assess the efficacy and safety of a covering method using polyglycolic acid (PGA) sheets and fibrin glue in preventing laryngopharyngeal bleeding after endoscopic laryngopharyngeal...
05:30
Co-treatment with endoscopic laryngopharyngeal surgery and endoscopic submucosal dissection. Auris Nasus Larynx. 2020 Oct 13;: Authors: Yamaguchi H, Sato H, Tsukahara K, Kagawa Y, Okamoto I, Shimizu A, Nagata N, Fukuzawa M, Sugimoto M, Kawai T, Itoi T Abstract OBJECTIVE: Endoscopic laryngopharyngeal surgery (ELPS) is an effective and minimally invasive treatment for pharyngeal cancers. However, the disadvantages of ELPS are the interference...
05:30
Augmentation of the posterior pharyngeal wall with autologous tragal cartilage for management of velopharyngeal valve insufficiency in adults. Auris Nasus Larynx. 2020 Oct 13;: Authors: Khafagy AG, Kassamy H, Mohamed AA Abstract OBJECTIVE: The study aims to evaluate posterior pharyngeal wall augmentation using autologous tragal cartilage graft in adults with velopharyngeal valve insufficiency (VPI). METHODS: The study included 23 patients...
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Outcome of an outpatient specialty clinic for chronic epipharyngitis. Auris Nasus Larynx. 2020 Oct 13;: Authors: Mogitate M, Sasaki Y, Komiyama A Abstract OBJECTIVE: In Japan, chronic epipharyngitis became a subject of interest in the 1960s and is currently garnering renewed attention. Previous studies have focused only on the similarities between the immunological characteristics of the tonsil and epipharynx and reported the efficacy of epipharyngeal...
05:30
Identification of Prognosis Associated microRNAs in HNSCC Subtypes Based on TCGA Dataset. Medicina (Kaunas). 2020 Oct 13;56(10): Authors: Petronacci CMC, García AG, Iruegas EP, Mundiña BR, Lorenzo Pouso AI, Sayáns MP Abstract Background and Objectives: Head and Neck Squamous Cell Carcinoma (HNSCC) includes cancers from the oral cavity, larynx, and oropharynx and is the sixth-most common cancer worldwide. MicroRNAs are small non-coding RNAs...
05:30
[Current diagnostic imaging and treatment planning for laryngeal cancer]. Radiologe. 2020 Oct 15;: Authors: Bozzato A, Pillong L, Schick B, Lell MM Abstract CLINICAL/METHODICAL ISSUE: Laryngeal cancer is the third most common malignancy in the head and neck region. Endoscopic laryngoscopy with assessment of vocal fold function, microlaryngoscopy with biopsy and computed tomography (CT)/magnetic resonance imaging (MRI) remain the cornerstones...
05:30
[Subjective significance of olfactory dysfunction after laryngectomy : Let's ask our patients]. HNO. 2020 Oct 14;: Authors: Steinau P, Walter S, Hübner J, Büntzel J Abstract BACKGROUND AND OBJECTIVE: Laryngectomy is usually associated with olfactory dysfunction. How do laryngectomees personally experience and feel about this change? MATERIALS AND METHODS: In cooperation with the Bundesverband der Kehlkopfoperierten (German Association...
05:30
Second Primary Tumors in head and neck cancer patients: the importance of a "tailored" surveillance.
Second Primary Tumors in head and neck cancer patients: the importance of a "tailored" surveillance. Oral Dis. 2020 Oct 14;: Authors: Bertolini F, Trudu L, Banchelli F, Schipilliti F, Napolitano M, Alberici MP, Depenni R, D'Angelo E, Mattioli F, Rubino L, Presutti L Abstract OBJECTIVE: Head and neck cancer survivors have increased risk of developing second primary tumors compared to overall population. Because second primary represent a major...
05:30
Related Articles Comparison of the MultiViewScope Stylet Scope and the direct laryngoscope with the Miller blade for the intubation in normal and difficult pediatric airways: A randomized, crossover, manikin study. PLoS One. 2020;15(8):e0237593 Authors: Godai K, Moriyama T, Kanmura Y Abstract BACKGROUND: Managing difficult pediatric airway is challenging. The MultiViewScope (MVS) Stylet Scope is reported to be useful in difficult pediatric...
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Related Articles Neonatal Mandibular Distraction Osteogenesis in Infants With Pierre Robin Sequence. J Craniofac Surg. 2020 Jun;31(4):1137-1141 Authors: Diep GK, Eisemann BS, Flores RL Abstract Pierre Robin sequence is the constellation of micrognathia, glossoptosis, and tongue-based airway obstruction. When airway obstruction is severe, feeding, growth, and respiratory demise are at risk. Neonatal mandibular distraction osteogenesis is a technique...
05:30
Related Articles Response to R. Waldman et al.: 'Does IL-4 inhibition play a role in dupilumab-associated conjunctivitis?' Br J Dermatol. 2020 05;182(5):1310-1312 Authors: Ardeleanu M, Shumel B, Rossi AB, Graham NMH PMID: 31853960 [PubMed - indexed for MEDLINE]
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Related Articles LINC01605 promotes the proliferation of laryngeal squamous cell carcinoma through targeting miR-493-3p. Eur Rev Med Pharmacol Sci. 2019 Dec;23(23):10379-10386 Authors: Wang XY, Wang L, Xu PC, Huang FJ, Jian X, Wei ZC, Chen YQ Abstract OBJECTIVE: The purpose of this study was to elucidate the potential influence of LINC01605 on the progression of laryngeal squamous cell carcinoma (LSCC) and the underlying mechanism. ...
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Related Articles Use of individual anatomical variations to customise window location in montgomery implant thyroplasty: A case series study. Clin Otolaryngol. 2019 11;44(6):1162-1165 Authors: Zapater E, Basterra J, López I, Oishi N, García-Lliberós A PMID: 31514258 [PubMed - indexed for MEDLINE]
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Related Articles LncRNA SNHG1 promotes cell proliferation in laryngeal cancer via Notch1 signaling pathway. Eur Rev Med Pharmacol Sci. 2019 Aug;23(15):6562-6569 Authors: Liu T, Zuo JJ, Li F, Xu YC, Zheng AY, Tao ZZ Abstract OBJECTIVE: We aimed at elucidating the potential function of long noncoding ribonucleic acids (lncRNAs) small nucleolar RNA host gene 1 (SNHG1) in the progression of laryngeal cancer (LC) and its underlying mechanism. ...
05:30
Effects of Different Diets on Microbiota in The Small Intestine Mucus and Weight Regulation in Rats.
Related Articles Effects of Different Diets on Microbiota in The Small Intestine Mucus and Weight Regulation in Rats. Sci Rep. 2019 06 11;9(1):8500 Authors: Meng Y, Li X, Zhang J, Wang C, Lu F Abstract While the microbial community of the small intestine mucus (SIM) may also play a role in human health maintenance and disease genesis, it has not been extensively profiled and whether it changes with diet is still unclear. To investigate the...
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Strain Elastosonography Measurement in Patients with Primary Muscle Tension Dysphonia Compared with Healthy Speakers: A Pilot Study. J Voice. 2020 Oct 14;: Authors: Azizi Ata N, Khoddami SM, Babaei-Ghazani A, Izadi F, Maroufizadeh S Abstract OBJECTIVES: The purpose of this study was to investigate real-time elastosonography (RTE) to measure strain of the (para)laryngeal muscles in patients with primary muscle tension dysphonia (MTD) and healthy...
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Corticosteroid discontinuation, complete clinical response and remission in juvenile dermatomyositis. Rheumatology (Oxford). 2020 Oct 17;: Authors: Kishi T, Warren-Hicks W, Bayat N, Targoff IN, Huber AM, Ward MM, Rider LG, with the Childhood Myositis Heterogeneity Study Group Abstract OBJECTIVE: A North American registry of JDM patients was examined for frequency of and factors associated with corticosteroid discontinuation, complete clinical...
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Axitinib plus avelumab in the treatment of recurrent glioblastoma: a stratified, open-label, single-center phase 2 clinical trial (GliAvAx). J Immunother Cancer. 2020 Oct;8(2): Authors: Awada G, Ben Salama L, De Cremer J, Schwarze JK, Fischbuch L, Seynaeve L, Du Four S, Vanbinst AM, Michotte A, Everaert H, Rogiers A, Theuns P, Duerinck J, Neyns B Abstract BACKGROUND: No treatment demonstrated to improve survival in patients with recurrent glioblastoma...
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Coprevalence of Presbycusis and Its Effect on Outcome of Voice Therapy in Patients With Presbyphonia. J Voice. 2020 Oct 14;: Authors: Park JH, Chae M, An YH, Shim HJ, Kwon M Abstract OBJECTIVE: To identify the coprevalence of presbycusis and presbycusis and analyze the effect of presbycusis on compliance and result of voice therapy in presbycusis patients. METHODS: This cross-sectional, prospective cohort study initially screened patients...
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Clinical Outcome and Toxicity in the Treatment of Anaplastic Thyroid Cancer in Elderly Patients. J Clin Med. 2020 Oct 09;9(10): Authors: Augustin T, Oliinyk D, Köhler VF, Rauch J, Belka C, Spitzweg C, Käsmann L Abstract BACKGROUND: The present study aims to evaluate the outcomes and toxicity of elderly anaplastic thyroid cancer (ATC) patients receiving (chemo)radiotherapy, as well as to identify prognostic factors. PATIENTS AND METHODS:...
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Bilateral immediate two-stage breast reconstruction in patients with unilateral breast cancer: Outcomes analysis and risk assessment. J Plast Reconstr Aesthet Surg. 2020 Sep 20;: Authors: Ozturk CN, Ozturk C, Soucise A, Ahsan N, Kuhn J, Platek M, Lohman R, Moon W, Gurunian R Abstract INTRODUCTION: Contralateral prophylactic mastectomy has the potential to decrease the occurrence of cancer and reduce psychological burden. However, it is known...
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The scratch collapse test: A systematic review. J Plast Reconstr Aesthet Surg. 2018 Dec;71(12):1693-1703 Authors: Čebron U, Curtin CM Abstract The diagnosis of nerve compression relies on collecting diagnostic clues from the history, physical examination, imaging and diagnostic testing. There are several provocative tests to aid in the diagnosis of nerve compression. The 'Scratch Collapse Test' (SCT) has emerged as a new provocative test to...
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A systematic review of outcomes following hand reconstruction using flaps from the superficial palmar branch of the radial artery (SUPBRA) system. J Plast Reconstr Aesthet Surg. 2020 Sep 19;: Authors: Mabvuure NT, Pinto-Lopes R, Iwuagwu FC, Sierakowski A Abstract BACKGROUND: Flaps based on the superficial branch of the radial artery (SUPBRA) are indicated when homo- or heterodigital flaps are inappropriate, but glabrous or like-for-like reconstruction...
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Plastic surgical management of skin cancer patients during the COVID-19 pandemic. J Plast Reconstr Aesthet Surg. 2020 Sep 20;: Authors: Rich H, Jones B, Malin I, Hemington-Gorse SJ, Cubitt JJ PMID: 33060056 [PubMed - as supplied by publisher]
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Erratum to "Capsular contracture around silicone mini implants following bacterial contamination: an in vivo comparative experimental study between textured and polyurethane implants" [Journal of Plastic, Reconstructive & Aesthetic Surgery 73(9) (2020) 1747-1757]. J Plast Reconstr Aesthet Surg. 2020 Oct 12;: Authors: Manav S, Ayhan MS, Deniz E, Özkoçer E, Elmas Ç, Yalinay M, Şahin E PMID: 33060055 [PubMed - as supplied by publisher]
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Breast reconstruction and the COVID-19 pandemic: Adapting practice. J Plast Reconstr Aesthet Surg. 2020 Sep 28;: Authors: Pace BD, Benson JR, Malata CM PMID: 33060054 [PubMed - as supplied by publisher]
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The rules for online clinical engagement in the COVID era. J Plast Reconstr Aesthet Surg. 2020 Aug 22;: Authors: Howgego G, Sharma I, Kalu P Abstract Coronavirus disease-2019 (COVID-19) has generated a need to rapidly increase online consulting in secondary care, an area in which it has previously been underutilised. We sought to review the guidance on conducting remote consultations and found that while there is a large amount of information...
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The governance of overseas surgical collaborations - BFIRST/BSSH. J Plast Reconstr Aesthet Surg. 2020 Aug 19;: Authors: Jemec B, Lam W, Hodgson SP, Jones JWM, Eckersley R, Nyamulani N, Riaz M, Fell M, Nicholas R, Bhopal R, Mendis K, Khan MRK, Sommerlad B Abstract Clinical governance is the structured approach to maintaining and improving the quality of patient care and is a vital part of global surgery. BFIRST and BSSH closely collaborate with...
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Upskilling the surgical workforce for vascular access provision during the COVID-19 pandemic - The Salisbury experience. J Plast Reconstr Aesthet Surg. 2020 Aug 26;: Authors: Valand P, Curran TA, Chow W, Howes R, Lloyd N, Williams S, Steele J Abstract A vascular access device is defined as a catheter inserted into veins allowing fluids and medicines to be delivered intravenously1. The need for such devices in acutely unwell patients has remained...
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Surgical treatment of symmastia: A systematic review of techniques, outcomes and complications. J Plast Reconstr Aesthet Surg. 2020 Sep 20;: Authors: Guillier D, Sapino G, Watfa W, Raffoul W, di Summa PG Abstract BACKGROUND: The term "symmastia" defines a confluence across the mid-sternal line of the breast mounds and subsequent loss of adhesion between sternum and pre-sternal skin. This condition can be congenital or, more frequently, iatrogenic....
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Redirection of lower eyelid eyelashes by eyelid margin splitting and anterior lamellar repositioning for patients with non-entropion trichiasis. J Plast Reconstr Aesthet Surg. 2020 Sep 20;: Authors: Zhang Y, Niu G, Zhang J, Qu S, Liu C, Lin H, Zhou Q, Bi Y Abstract OBJECTIVE: To report outcomes of a surgical technique of eyelid margin splitting and anterior lamellar repositioning with lower eyelid non-entropion trichiasis. METHOD:...
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Delta Neutrophil Index and Neutrophil-to-Lymphocyte Ratio in the Differentiation of Thyroid Malignancy and Nodular Goiter. World J Surg. 2020 Oct 16;: Authors: Bozan MB, Yazar FM, Kale İT, Yüzbaşıoğlu MF, Boran ÖF, Azak Bozan A Abstract BACKGROUND: It was aimed to evaluate the relationship between delta neutrophil index (DNI) and neutrophil-to-lymphocyte ratio (NLR) in the preoperative differentiation of nodular goiter and thyroid malignancy....
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The Usefulness of a Preoperative Nomogram for Predicting the Probability of Conversion from Laparoscopic to Open Distal Pancreatectomy: A Single-Center Experience. World J Surg. 2020 Oct 15;: Authors: Casadei R, Ricci C, Ingaldi C, Alberici L, Vaccaro MC, Galasso E, Minni F Abstract BACKGROUND: Laparoscopic distal pancreatectomy (LDP) represents a challenging procedure with a high conversion rate. A nomogram is a simple statistical predictive...
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Early Induction of Bedside Pneumoperitoneum in the Management of Residual Pleural Space and Air Leaks After Pulmonary Resection. World J Surg. 2020 Oct 15;: Authors: Pecoraro A, Garbarino GM, Peritore V, Tiracorrendo M, Andreetti C, Ibrahim M, Rendina EA, Mercantini P Abstract BACKGROUND: The pneumoperitoneum to treat prolonged air leaks or pleural space problems after pulmonary resection has been successfully used for decades. The aim of the...
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Evaluation of Perioperative Intestinal Motility Using a Newly Developed Real-Time Monitoring System During Surgery. World J Surg. 2020 Oct 15;: Authors: Ogawa M, Namikawa T, Oki T, Munekage M, Maeda H, Kitagawa H, Dabanaka K, Sugimoto T, Kobayashi M, Sakata O, Matsuda K, Hanazaki K Abstract BACKGROUND: This study aimed to investigate perioperative intestinal motility using a novel bowel sound monitoring system in patients undergoing breast...
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Letter to the Editor: Trends in Appendicitis Among Pregnant Women, the Risk for Cardiac Arrest, and Maternal-Fetal Mortality. World J Surg. 2020 Oct 14;: Authors: Jama MA, Perin G, Balasubramanian SP PMID: 33057763 [PubMed - as supplied by publisher]
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Determinants of Breast-Conserving Therapy in the Asian Population: A Systematic Review. World J Surg. 2020 Oct 13;: Authors: Galeano Machuca MP, Cheng SC, Jou TH, Cheng CT Abstract BACKGROUND: Treatment guidelines recommend breast-conserving therapy (BCT) for patients with early-stage breast cancer. However, Asian patients choose mastectomy over BCT, and the factors influencing this choice are unknown. This review aimed to identify the factors...
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The Challenges of Implementing Artificial Intelligence into Surgical Practice. World J Surg. 2020 Oct 13;: Authors: Tranter-Entwistle I, Wang H, Daly K, Maxwell S, Connor S Abstract BACKGROUND: Artificial intelligence is touted as the future of medicine. Classical algorithms for the detection of common bile duct stones (CBD) have had poor clinical uptake due to low accuracy. This study explores the challenges of developing and implementing...
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Related Articles Neonatal exposure to an inflammatory cytokine, epidermal growth factor, results in the deficits of mismatch negativity in rats. Sci Rep. 2019 05 16;9(1):7503 Authors: Jodo E, Inaba H, Narihara I, Sotoyama H, Kitayama E, Yabe H, Namba H, Eifuku S, Nawa H Abstract Perinatal exposure to epidermal growth factor (EGF) induces various cognitive and behavioral abnormalities after maturation in non-human animals, and is used for...
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Assessment of otolith function using vestibular evoked myogenic potential in women during pregnancy.
Assessment of otolith function using vestibular evoked myogenic potential in women during pregnancy. Braz J Otorhinolaryngol. 2020 Sep 28;: Authors: Bhavana G, Kumar K, E A Abstract INTRODUCTION: More than 50% of pregnant women experience dizziness frequently in the first two gestational trimesters. During pregnancy, the changes in the metabolism of hormones are responsible for the ovarian cycle resulting in either peripheral or central vestibular...
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Effect of septoplasty on left ventricular myocardial performance in patients with nasal septum deviation. Braz J Otorhinolaryngol. 2020 Sep 26;: Authors: Kaya H, Kurt E, Koparal M, Tibilli H, Hosoglu Y, Kafadar S, Suner A, Türkmen S Abstract INTRODUCTION: Nasal septum deviation is the leading cause of upper airway obstruction. Chronic upper airway obstruction may cause myocardial injury due to chronic hypoxia. Effects of septoplasty on left...
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Answer to the editor: "Factors influencing the quality of life of children with cochlear implants". Braz J Otorhinolaryngol. 2020 Sep 29;: Authors: da Silva VAR, Caixeta Guimarães A, Menino Castilho A PMID: 33055010 [PubMed - as supplied by publisher]
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Laryngo-tracheobronchial amyloidosis. Braz J Otorhinolaryngol. 2020 Sep 09;: Authors: Uyaguari JP, Quizhpe PJ, Lima E PMID: 33051158 [PubMed - as supplied by publisher]
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29 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Skull Base These pubmed results were generated on 2020/10/19PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Runs of homozygosity (ROH) are chromosomal stretches that in a diploid genome appear in a homozygous state and display identical alleles at multiple contiguous loci. This study aimed to systematically compare the genomic distribution of the ROH islands among five populations of wild vs. commercial chickens of both layer and broiler type. To this end, we analyzed whole genome sequences of 115 birds including white layer (WL, n=25), brown layer (BL, n=25), broiler line A (BRA, n=20), broiler line B...
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Stem cells are tightly controlled in vivo. Both the balance between self-renewal and differentiation and the rate of proliferation are often regulated by multiple factors. The Caenorhabditis elegans hermaphrodite germ line provides a simple and accessible system for studying stem cells in vivo. In this system, GLP-1/Notch activity prevents the differentiation of distal germ cells in response to ligand production from the nearby distal tip cell, thereby supporting a stem cell pool. However, a delay...
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Endoscopic Orbital Decompression: Technical Pearls and Pitfalls of an Evolving Technique. Am J Rhinol Allergy. 2020 Oct 13;:1945892420965479 Authors: Shah J, Ting J, Sindwani R Abstract BACKGROUND: First described in the early 1990s, endoscopic orbital decompression has become increasingly popular and has been shown to be a safe and effective approach for surgical decompression of the medial and inferior orbit. METHODS: We present...
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Targeting the sensory feedback within the swallowing network-Reversing artificially induced pharyngolaryngeal hypesthesia by central and peripheral stimulation strategies. Hum Brain Mapp. 2020 Oct 17;: Authors: Muhle P, Labeit B, Wollbrink A, Claus I, Warnecke T, Wolters CH, Gross J, Dziewas R, Suntrup-Krueger S Abstract Pharyngolaryngeal hypesthesia is a major reason for dysphagia in various neurological diseases. Emerging neuromodulation...
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Prosthetic Rehabilitation of a Nasomaxillary Defect Utilizing a two-Component Prosthesis: a Clinical Report. J Dent (Shiraz). 2020 Sep;21(3):244-248 Authors: Gandhewar M, A Bankar T, Selecman A, Ahuja S Abstract Nasomaxillary defects may affect patients' speech, mastication, swallowing, breathing, quality of life, psychology, and social behavior. A combination of surgical reconstruction and prosthetic rehabilitation is frequently required to...
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Clinical Effects and Safety of Electroacupuncture for the Treatment of Poststroke Dysphagia: A Comprehensive Systematic Review and Meta-Analysis. Evid Based Complement Alternat Med. 2020;2020:1560978 Authors: Huang J, Shi Y, Qin X, Shen M, Wu M, Huang Y Abstract Objectives: Electroacupuncture (EA), an extension of acupuncture, which is based on traditional acupuncture combined with modern electrotherapy, is commonly used for poststroke dysphagia...
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Electroacupuncture Involved in Motor Cortex and Hypoglossal Neural Control to Improve Voluntary Swallowing of Poststroke Dysphagia Mice. Neural Plast. 2020;2020:8857543 Authors: Cui S, Yao S, Wu C, Yao L, Huang P, Chen Y, Tang C, Xu N Abstract The descending motor nerve conduction of voluntary swallowing is mainly launched by primary motor cortex (M1). M1 can activate and regulate peripheral nerves (hypoglossal) to control the swallowing. Acupuncture...
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Swallowing and Communication Management of Tracheostomy and Laryngectomy in the Context of COVID-19: A Review. JAMA Otolaryngol Head Neck Surg. 2020 Oct 15;: Authors: Vergara J, Starmer HM, Wallace S, Bolton L, Seedat J, de Souza CM, Freitas SV, Skoretz SA Abstract Importance: The care of patients with a surgically modified airway, such as tracheostomy or laryngectomy, represents a challenge for speech-language pathologists (SLPs) in the context...
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Effects of Physical Rehabilitation and Nutritional Intake Management on Improvement in Tongue Strength in Sarcopenic Patients. Nutrients. 2020 Oct 12;12(10): Authors: Nagano A, Maeda K, Koike M, Murotani K, Ueshima J, Shimizu A, Inoue T, Sato K, Suenaga M, Ishida Y, Mori N Abstract The study aimed to investigate the impact of physical intervention and the amount of nutritional intake on the increase in tongue strength and swallowing function...
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Sensitivity and Specificity of Bedside Screening Tests for Detection of Aspiration in Patients Admitted to a Public Rehabilitation Hospital. Dysphagia. 2020 Oct 14;: Authors: Velasco LC, Imamura R, Rêgo APV, Alves PR, da Silva Peixoto LP, de Oliveira Siqueira J Abstract Early detection of dysphagia and specifically aspiration is essential to prevent and reduce complications of hospitalized patients in rehabilitation centers. Bedside screening...
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The histone H2B ubiquitin ligase RNF40 is required for HER2-driven mammary tumorigenesis. Cell Death Dis. 2020 Oct 17;11(10):873 Authors: Wegwitz F, Prokakis E, Pejkovska A, Kosinsky RL, Glatzel M, Pantel K, Wikman H, Johnsen SA Abstract The HER2-positive breast cancer subtype (HER2+-BC) displays a particularly aggressive behavior. Anti-HER2 therapies have significantly improved the survival of patients with HER2+-BC. However, a large number...
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Can we avoid axillary lymph node dissection in N2 breast cancer patients with chemo-sensitive tumours such as HER2 and TNBC? Breast Cancer Res Treat. 2020 Oct 17;: Authors: Garcia-Tejedor A, Fernandez-Gonzalez S, Ortega R, Gil-Gil M, Perez-Montero H, Fernandez-Montolí E, Stradella A, Recalde S, Soler T, Petit A, Bajen MT, Benitez A, Guma A, Campos M, Pla MJ, Martinez E, Laplana M, Pernas S, Perez-Sildekova D, Catala I, Ponce J, Falo C Abstract ...
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Exosomal miR-1246 and miR-155 as predictive and prognostic biomarkers for trastuzumab-based therapy resistance in HER2-positive breast cancer. Cancer Chemother Pharmacol. 2020 Oct 17;: Authors: Zhang Z, Zhang L, Yu G, Sun Z, Wang T, Tian X, Duan X, Zhang C Abstract PURPOSE: This study aimed to investigate the predictive and prognostic roles of circulating exosomal miRNAs in breast cancer treated with trastuzumab-based chemotherapy. ...
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Durable clinical benefit from pyrotinib combined with carboplatin in HER2-positive relapsed breast cancer previously treated with taxanes, anthracyclines, and trastuzumab. Ann Palliat Med. 2020 Sep;9(5):3684-3689 Authors: Zhu W, Wu J, Cui M, Zhang L Abstract Patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer inevitably progressed after a short response to initial trastuzumab treatment, suggesting a possibility...
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Analysis of the serial circulating tumor cell count during neoadjuvant chemotherapy in breast cancer patients. Sci Rep. 2020 Oct 15;10(1):17466 Authors: Gwark SC, Kim J, Lee CH, Kim YH, Kim MS, Hong SW, Choi MY, Jeon BH, Kwon NJ, Kim KY, Kim Y, Chang S, Yu JH, Park JY, Ahn JH, Jung KH, Kim SB, Lee HJ, Gong GY, Lee SB, Chung IY, Ko BS, Kim HJ, Lee JW, Son BH, Ahn SH Abstract We evaluated the prognostic implications of the circulating tumor cell...
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FDA Approval Summary: Tucatinib for the Treatment of Patients with Advanced or Metastatic HER2-Positive Breast Cancer. Clin Cancer Res. 2020 Oct 14;: Authors: Shah M, Wedam S, Cheng J, Fiero MH, Xia H, Li F, Fan J, Zhang X, Yu J, Song P, Chen W, Ricks TK, Chen XH, Goldberg KB, Gong Y, Pierce WF, Tang S, Theoret MR, Pazdur R, Amiri-Kordestani L, Beaver JA Abstract On April 17, 2020, the FDA approved tucatinib in combination with trastuzumab...
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Predictive value of tumor-infiltrating lymphocytes for pathological response to neoadjuvant chemotherapy in breast cancer patients with axillary lymph node metastasis. Surg Today. 2020 Oct 14;: Authors: Yokotani T, Ikeda N, Hirao T, Tanaka Y, Morita K, Fujii T, Ohbayashi C, Nakamura T, Kobayashi T, Sho M Abstract PURPOSE: We investigated the role of tumor-infiltrating lymphocytes (TILs) in pretreatment primary breast cancer to predict pathological...
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The role of TP53 pathogenic variants in early-onset HER2-positive breast cancer. Fam Cancer. 2020 Oct 14;: Authors: Escudeiro C, Pinto C, Vieira J, Peixoto A, Pinto P, Pinheiro M, Santos C, Guerra J, Lisboa S, Santos R, Silva J, Leal C, Coimbra N, Lopes P, Ferreira M, Sousa AB, Teixeira MR Abstract Breast cancer is the most frequent event in Li-Fraumeni syndrome associated with germline TP53 variants. Some studies have shown that breast cancers...
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FGF13 interaction with SHCBP1 activates AKT-GSK3α/β signaling and promotes the proliferation of A549 cells. Cancer Biol Ther. 2020 Oct 16;:1-11 Authors: Lu H, Yin M, Wang L, Cheng J, Cheng W, An H, Zhang T Abstract FGF13, a member of the FGF subfamily, has been found to be highly expressed in cancer cells such as prostate cancer, melanoma, glioma and multiple myeloma. However, the mechanism of FGF13 function during cancer cell proliferation...
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Metallophosphoesterase 1, a novel candidate gene in hepatocellular carcinoma malignancy and recurrence. Cancer Biol Ther. 2020 Oct 15;:1-9 Authors: Chen X, Xu J, Wang P, Shang L, Guo J, Huang L, Jiang YA, Chen J, Chen H, Shang Y, Zhang Q Abstract BACKGROUND: There is an unmet need to identify novel mechanism-based prognostic genes associated with hepatocellular carcinoma (HCC) recurrence that can predict patient outcomes and provide therapeutic...
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Cyclin E overexpression confers resistance to trastuzumab through noncanonical phosphorylation of SMAD3 in HER2+ breast cancer. Cancer Biol Ther. 2020 Oct 14;:1-11 Authors: Decker JT, Kandagatla P, Wan L, Bernstein R, Ma JA, Shea LD, Jeruss JS Abstract The efficacy of trastuzumab, a treatment for HER2+ breast cancer, can be limited by the development of resistance. Cyclin E (CCNE) overexpression has been implicated in trastuzumab resistance....
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Paratesticular Dermoid Cyst Mimicking a Torsed Supernumerary Testis: A Case Report. Am J Case Rep. 2020 Oct 18;21:e923752 Authors: Betancourt-Torres M, Figueroa-Diaz L, Rodriguez-Mojica W Abstract BACKGROUND Paratesticular tumors are rare causes of scrotal masses; most are benign and arise from the spermatic cord. We present the case of a dermoid cyst, a rare benign paratesticular tumor mimicking a torsed supernumerary testis. CASE REPORT An...
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A Case of Critical Lower-Limb Ischemia in a 29-Year-Old Man with Autoimmune Polyglandular Syndrome Type 1 (APS-1). Am J Case Rep. 2020 Oct 17;21:e924705 Authors: Ennab RM, Saadeh NA Abstract BACKGROUND Autoimmune polyglandular syndrome type 1 (APS-1) is an extremely rare autoimmune disorder with an autosomal recessive inheritance pattern. Its manifestations present in chronological sequence of the components mucocutaneous candidiasis, Addison...
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Rare Human Epidermal Growth Factor Receptor 2 (HER-2)-Positive Neuroendocrine Carcinoma of the Breast: A Case Report with 9-Year Follow-up. Am J Case Rep. 2020 Oct 17;21:e925895 Authors: Marijanović I, Kraljević M, Buhovac T, Karan Križanac D Abstract BACKGROUND Neuroendocrine carcinoma of the breast (NECB) is very rare, accounting for 0.1% of all breast tumors and less than 1% of all neuroendocrine tumors. Most NECBs are hormone receptor-positive...
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Spontaneous Biloma Resulting from Intrahepatic Bile Duct Perforation Coexisting with Intrahepatic Cholelithiasis and Cholangiocarcinoma: A Case Report and Literature Review. Am J Case Rep. 2020 Oct 16;21:e926270 Authors: Suzuki K, Hashimoto T, Osugi S, Toyota N, Omagari K, Tamura A Abstract BACKGROUND Spontaneous biloma is a rare non-traumatic disease in which an extrahepatic or intrahepatic bile duct perforates spontaneously with no discernable...
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An Uncommon Lung Neoplasm in a Young Patient: Diagnostic Challenges. Am J Case Rep. 2020 Oct 16;21:e926038 Authors: Leser FS, Romano LD, de Resende KR, Lapa E Silva JR Abstract BACKGROUND Adenosquamous carcinoma of the lung (ASC) is a rare subtype of non-small-cell lung carcinoma (NSCLC), histologically defined by the presence of both squamous cell carcinoma and adenocarcinoma components. This aggressive malignancy has been rarely described...
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Torsades de Pointes During Myringotomy in a Child with Congenital Long QT Syndrome: A Case Report. Am J Case Rep. 2020 Oct 15;21:e925602 Authors: Coleman M, Imundo JR, Cortez D, Cohen MH, Dhar P, Dalal PG Abstract BACKGROUND Long QT syndrome (LQTS) is an arrhythmogenic heart condition that can be congenital or acquired. Prolonged ventricular repolarizations in individuals with the disorder can cause fatal arrhythmias. Abnormal functioning of...
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Third Cranial Nerve Palsy Presenting with Unilateral Diplopia and Strabismus in a 24-Year-Old Woman with COVID-19. Am J Case Rep. 2020 Oct 15;21:e925897 Authors: Belghmaidi S, Nassih H, Boutgayout S, El Fakiri K, El Qadiry R, Hajji I, Bourrahouate A, Moutaouakil A Abstract BACKGROUND Coronavirus disease (COVID 19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is the causative agent of a serious disease that is...
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Clinical Characteristics of 3 Patients Infected with COVID-19: Age, Interleukin 6 (IL-6), Lymphopenia, and Variations in Chest Computed Tomography (CT). Am J Case Rep. 2020 Oct 14;21:e924905 Authors: Huang J, Li J, Zou Z, Kandathil A, Liu J, Qiu S, Oz OK Abstract BACKGROUND COVID-19 has been identified as the cause of the large outbreak of pneumonia in patients in Wuhan with shared history of exposure to the Huanan seafood market; however,...
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Limitations of Dutch Growth Research Foundation Commercial Software Weight Velocity for Age Standard Deviation Score. Am J Case Rep. 2020 Oct 14;21:e925551 Authors: Van Gemert MJC, Vlaming M, Köseoğlu B, Bruijninckx CMA, Van Leeuwen TG, Neumann MHA, Sauer PJJ Abstract BACKGROUND The commercial software for hospitals, Weight Velocity for Age Standard Deviation Score (SDSWVA), claims to document the growth and development of children, although...
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Current Trends in Enzyme Inhibition and Docking Analysis in Drug Design-Part -I. Curr Top Med Chem. 2020;20(23):2044-2045 Authors: Geronikaki A PMID: 33054702 [PubMed - in process]
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Natriuretic peptides as the basis of peptide drug discovery for cardiovascular diseases. Curr Top Med Chem. 2020 Oct 13;: Authors: Lerner Y, Hanout W, Ben-Uliel SF, Gani S, Leshem MP, Qvit N Abstract : Cardiovascular diseases (CVDs) are the leading global cause of death, accounting for more than 17.6 million deaths per year in 2016, a number that is expected to grow to more than 23.6 million by 2030. While many technologies are currently under...
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Correction: Co-targeting the MAPK and PI3K/AKT/mTOR pathways in two genetically engineered mouse models of schwann cell tumors reduces tumor grade and multiplicity. Oncotarget. 2020 Sep 29;11(39):3618-3620 Authors: Watson AL, Keller BJ, Williams KA, Damle NN, Finnerty SJ, Anderson LK, Greeley AD, Keng VW, Rahrmann EP, Halfond AL, Powell NM, Collins MH, Rizvi T, Moertel CL, Ratner N, Largaespada DA Abstract [This corrects the article DOI:...
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Meta-analysis of gene expression profiling reveals novel basal gene signatures in MCF-10A cells transformed with cadmium. Oncotarget. 2020 Sep 29;11(39):3601-3617 Authors: Blommel K, Knudsen CS, Wegner K, Shrestha S, Singhal SK, Mehus AA, Garrett SH, Singhal S, Zhou X, Voels B, Sens DA, Somji S Abstract Cadmium (Cd2+) is an environmental toxicant and a human carcinogen. Several studies show an association of Cd2+ exposure to the development...
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NRXN1 as a novel potential target of antibody-drug conjugates for small cell lung cancer. Oncotarget. 2020 Sep 29;11(39):3590-3600 Authors: Yotsumoto T, Maemura K, Watanabe K, Amano Y, Matsumoto Y, Zokumasu K, Ando T, Kawakami M, Kage H, Nakajima J, Yatomi Y, Nagase T, Takai D Abstract Small cell lung cancer (SCLC) is a high-grade malignancy, and treatment strategies have not changed for decades. In this study, we searched for novel targets...
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PD-1/PD-L1 expression in anal squamous intraepithelial lesions. Oncotarget. 2020 Sep 29;11(39):3582-3589 Authors: Bucau M, Gault N, Sritharan N, Valette E, Charpentier C, Walker F, Couvelard A, Abramowitz L Abstract INTRODUCTION: Studies have shown that the PD-1/PD-L1 immunomodulatory pathway slows down anti-tumor immunity in a number of cancers. The description of the expression of these molecules has never been performed in anal low-grade/high...
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Targeted lymphodepletion with a CD45-directed antibody radioconjugate as a novel conditioning regimen prior to adoptive cell therapy. Oncotarget. 2020 Sep 29;11(39):3571-3581 Authors: Dawicki W, Allen KJH, Garg R, Geoghegan EM, Berger MS, Ludwig DL, Dadachova E Abstract Chimeric antigen receptor (CAR) T cell therapies, and adoptive cell therapy (ACT) in general, represent one of the most promising anti-cancer strategies. Conditioning has...
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Ferroptosis of epithelial ovarian cancer: genetic determinants and therapeutic potential. Oncotarget. 2020 Sep 29;11(39):3562-3570 Authors: Lin CC, Chi JT Abstract Epithelial ovarian cancer (OVCA) is the most lethal gynecologic cancer. Current treatment for OVCA involves surgical debulking of the tumors followed by combination chemotherapies. While most patients achieve complete remission, many OVCA will recur and develop chemo-resistance....
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Minority MOMP: a toxic, slow demise. Oncotarget. 2020 Sep 29;11(39):3559-3561 Authors: Xu Y, Surman DR, Ripley RT PMID: 33062191 [PubMed]
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63 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: epilepsy treatment These pubmed results were generated on 2020/10/19PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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