BCG vaccine, a ray of hope in treating Severe Acute Respiratory Syndrome (SARS). Infect Disord Drug Targets. 2020 Oct 16;: Authors: Banerjee AB, Singh TG, Prashar A Abstract In December 2019 in Wuhan, China, the Severe Acute Respiratory Syndrome - Corona Virus - 2 (SARS-CoV-2) (also 2019 nCoV) was first discovered. Later WHO declared that SARS-CoV-2 was responsible for Coronavirus Disease 2019 (COVID-19). The round, elliptical or pleomorphic...
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COVID-19 And Type 2 Diabetes Mellitus: Hydroxychloroquine May Be The Holy Grail. Infect Disord Drug Targets. 2020 Oct 13;: Authors: Pal R, Bhasin MK, Bhadada SK Abstract The novel coronavirus disease (COVID-19) is on the rampage claiming over 297000 lives globally. Disease severity and mortality rates are higher in patients with underlying diabetes mellitus. Till date, there exists no effective vaccine or therapy against COVID-19. However,...
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Erratum: Polarization of M1 and M2 Human Monocyte-Derived Cells and Analysis with Flow Cytometry upon Mycobacterium tuberculosis Infection. J Vis Exp. 2020 Oct 14;(164): Authors: Abstract An erratum was issued for: Polarization of M1 and M2 Human Monocyte-Derived Cells and Analysis with Flow Cytometry upon Mycobacterium tuberculosis Infection. Author and affiliation information was updated. The author and affiliation information was updated...
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Phase I studies of darinaparsin in patients with relapsed or refractory peripheral T-cell lymphoma: a pooled analysis of two phase I studies conducted in Japan and Korea. Jpn J Clin Oncol. 2020 Oct 14;: Authors: Ogura M, Kim WS, Uchida T, Uike N, Suehiro Y, Ishizawa K, Nagai H, Nagahama F, Sonehara Y, Tobinai K Abstract OBJECTIVE: Two phase I studies of darinaparsin including Japanese and Korean patients with relapsed/refractory peripheral...
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116 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Future Oncology These pubmed results were generated on 2020/10/19PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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[Perceptions and attitudes of nurses on emotional and sexual lives of cancer patients]. Bull Cancer. 2020 Oct 14;: Authors: Mbalè E, D'Hondt L, Vastrade C, Coppieters Y Abstract INTRODUCTION: Despite the frequency of sexual issues during cancer care, the majority of nurses do not bring up the topic with their patients. The purpose of this study is to encourage nurses in oncology and hematology units on how to better participate in the assessment...
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[Crohn's disease and autologous hemapoietic cell transplantation: Guidelines from the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)]. Bull Cancer. 2020 Oct 13;: Authors: Puyade M, Treton X, Alric L, Badoglio M, Castilla Llorente C, Fotsing G, Marjanovic Z, Rovira M, Terriou L, Torregrosa Díaz Jose M, Tran-Minh ML, Allez M, Pugnet G, Laharie D, Yakoub-Agha I, Farge D Abstract Crohn's Disease (CD) is an auto-inflammatory...
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[Tumors affecting the temporomandibular joint - a literature review]. Bull Cancer. 2020 Oct 12;: Authors: Schlund M, Roland-Billecart T, Aubert S, Nicot R Abstract Benign and malign tumors can affect the temporomandibular joint (TMJ) as any other articulation. Nevertheless, TMJ tumors are rare and mostly benign. Their clinical expression is varied including symptomatology similar to TMJ dysfunctional disorders, otologic or neurologic pathologies....
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[Palliative care medical consultation in a hematology department. Feedback and critical reflection on a year of practice]. Bull Cancer. 2020 Oct 12;: Authors: Prod'homme C Abstract INTRODUCTION: Patients with hematological malignancies have less access to palliative care than other cancer patients, and benefit from it later in the course of their disease, though symptom burden is just as heavy. METHODS: We created a specialized outpatient...
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[Influence of age on indications and modalities of radiation therapy: What to keep in mind for adolescents and young adults?] Bull Cancer. 2020 Oct 10;: Authors: Jouglar E, Escande A, Martin V, Demoor-Goldschmidt C, Carrie C, Claude L, Bernier-Chastagner V Abstract When using radiation therapy for adolescents and young adults (AYA), paediatricians, adults' oncologists and radiation oncologists need to keep in mind several particularities through...
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C-Myc signaling pathway in treatment and prevention of brain tumors. Curr Cancer Drug Targets. 2020 Oct 16;: Authors: Ashrafizadeh M, Zarabi A, Hushmandi K, Moghadam ER, Hashemi F, Daneshi S, Hashemi F, Tavakol S, Mohammadinejad R, Najafi M, Dudha N, Garg M Abstract Brain tumors are responsible for high morbidity and mortality worldwide. Several factors such as the presence of blood-brain barrier (BBB), sensitive location in the brain, and...
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Abstract Sensorineural hearing loss is a prevalent problem that adversely impacts quality of life by compromising interpersonal communication. While hair cell damage is readily detectable with the clinical audiogram, this traditional diagnostic tool appears inadequate to detect lost afferent connections between inner hair cells and auditory nerve (AN) fibers, known as cochlear synaptopathy. The envelope-following response (EFR) is a scalp-recorded response to amplitude modulation,...
Mon Oct 19, 2020 03:00
147 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: rare cancers These pubmed results were generated on 2020/10/19PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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The caged bird sign of achalasia: A case series describing a new radiologic sign that can be reliably used in a resource-poor setting to diagnose achalasia. Int J Surg Case Rep. 2020 Oct 07;76:324-327 Authors: Singh Y, Shah A, Samlal N, Mohammed S, Naraynsingh V Abstract INTRODUCTION: Achalasia is an uncommon oesophageal motility disorder caused by failed relaxation of a hypertensive lower oesophageal sphincter in response to swallowing. It...
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Huge gangrenous gallbladder presenting as gastro-esophageal reflux disease successfully treated by laparoscopic cholecystectomy: Case report and literature review. Int J Surg Case Rep. 2020 Oct 02;76:315-319 Authors: Elkbuli A, Meneses E, Kinslow K, McKenney M, Boneva D Abstract INTRODUCTION: Gallbladder disease is a common surgical pathology. Gallstones can remain asymptomatic or develop into an acute cholecystitis and need for surgical intervention....
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Recurrence of ruptured intracranial epidermoid cyst - A rare case report and presentation. Int J Surg Case Rep. 2020 Oct 01;76:310-314 Authors: Ghartimagar D, Shrestha MK, Ghosh A Abstract INTRODUCTION: Intracranial epidermoid cysts are congenital tumors that develop from ectodermal remnants during neuroembryogenesis between the third and fifth weeks of gestation. These tumors are benign and usually present with local mass effect. Here, we...
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Laparoscopic resection of an adrenal oncocytic neoplasm: Report of a case and review of the literature. Int J Surg Case Rep. 2020 Sep 29;76:305-309 Authors: St-Amour P, Djafarrian R, Zingg T, La Rosa S, Demartines N, Matter M Abstract INTRODUCTION: Oncocytic adrenal neoplasms are rare and mostly benign lesions. Available literature supports indication for a surgical resection, but criteria to predict aggressive behavior are unreliable, thus...
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Asymptomatic large duodenal GIST - An incidental finding in abdominopelvic ultrasonography: A case report. Int J Surg Case Rep. 2020 Sep 29;76:301-304 Authors: Santos AJ, Tojal A, Duarte L, Marques C, Pinheiro LF, Casimiro C Abstract INTRODUCTION: Duodenal GISTs are rare mesenchymal tumors of the digestive tract. They usually present as gastrointestinal bleeding or non-specific abdominal pain, but they can also be asymptomatic. High-risk GISTs...
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Case report on a rare cause of silent duodenal perforation. Int J Surg Case Rep. 2020 Oct 01;76:320-323 Authors: Rajaguru K, Sheong SC Abstract INTRODUCTION: Foreign body ingestion is a common clinical scenario encountered in clinical practice. Perforations related to foreign bodies are rare (<1%) but can present as a serious element in Emergency surgery. The most common site of perforations are angulated areas like ileocecal valve, sigmoid...
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A case of hepatic venous outflow obstruction caused by migration of the remnant liver into the subphrenic space after extended posterior sectionectomy of the liver. Int J Surg Case Rep. 2020 Oct 06;76:297-300 Authors: Kanno H, Yoshida A, Goto Y, Hisaka T, Akagi Y, Okuda K Abstract INTRODUCTION: Hepatic venous outflow obstruction (HVOO) is a rare complication of hepatectomy. We report a case of HVOO caused by remnant liver migration into the...
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Distal pancreatectomy after pancreatic injury, in two pediatric patients. Int J Surg Case Rep. 2020 Oct 07;76:293-296 Authors: Hadjizacharias T, Kaliviotis I, Kottakis G, Pavlides O, Papalouka D, Polydorou A Abstract INTRODUCTION: Although serious trauma is rare in pediatric patients, the management of blunt force trauma to the abdomen remains a challenge for Child Surgery Departments. Pancreatic injury comprises the fourth most common injury...
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Emergency laparoscopic resection of the anterior rectum due to rectal trauma secondary to compressed air, case report. Int J Surg Case Rep. 2020 Oct 06;76:288-292 Authors: Gómez D, Cabrera LF, Pedraza M, Mendoza-Zuchini A, Sánchez N, Cure HW, Cure Bulicie HO, Pulido JA Abstract In the XIX century, the surgeon faces surgical challenges due to the creation of new technologies. Accidental or compressed air-induced injury to the colon and rectum...
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Leiomyoma of esophagus-A case report. Int J Surg Case Rep. 2020 Sep 23;76:285-287 Authors: Thakut G, Murchite SA, Kulkarni RM, Gaikwad VV Abstract INTRODUCTION: Benign tumors of the esophagus are rare. However, among them, leiomyomas are common. Tumors larger than 5 cm are rare and may present as dysphagia or epigastric pain. Combined esophagoscopy and video-assisted thoracoscopic surgery or laparoscopic trans hiatal resection are used the...
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Temporary use of unusually high dose of catecholamine improved severe ventricular dysfunction associated with stunned myocardium without significant myocardial injury in a post cardiac surgical patient: A case report. Int J Surg Case Rep. 2020 Oct 07;76:282-284 Authors: Kim H, Shin YC Abstract INTRODUCTION: Some cardiac surgical patients present low cardiac output syndrome due to ventricular dysfunction resulting from postischemic myocardial...
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Radical resection and improvised manubriosternal reconstruction technique for solitary manubriosternal metastasis from papillary thyroid cancer. Int J Surg Case Rep. 2020 Oct 07;76:278-281 Authors: Chaudhry IUH, Cheema A, Aqeel C, Abbas A Abstract INTRODUCTION: Thyroid papillary carcinoma rarely present as manubriosternum metastasis. The standard treatment for patients with metastatic disease is iodine ablation therapy. A surgical resection...
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Liposarcoma of the spermatic cord presenting as an inguinal hernia. Int J Surg Case Rep. 2020 Oct 02;76:274-277 Authors: Wetzel E, Adjamian N, Diaz G, Steen S, Hobbs J Abstract INTRODUCTION: Dedifferentiated liposarcoma is a rare, highly malignant, rapidly recurring tumor. When found in the spermatic cord, this tumor may deceptively present as an inguinal hernia, and due to its rarity, may not be readily identified. PRESENTATION OF...
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Tuberculoma of spine mimicking intramedullary tumour: A case report. Int J Surg Case Rep. 2020 Sep 24;76:231-236 Authors: Biakto KT, Arifin J, Wonggokusuma G, Micelli C Abstract INTRODUCTION: Spinal intramedullary tuberculoma (IMTB) is a rare disease that accounts for 1 to 2/100,000 patients with tuberculosis [1]. This case demonstrated that this patient had atypical presentations compared to common tuberculosis considering that IMTB cases...
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Effectiveness of gallium scintigraphy in diagnosing a spontaneous giant chronic expanding hematoma of the adrenal gland: A case report. Int J Surg Case Rep. 2020 Oct 07;76:270-273 Authors: Kajioka H, Morito T, Kokudo Y, Muraoka A Abstract INTRODUCTION: A chronic expanding hematoma in the retroperitoneal space is a rare disease with poorly understood pathology, and preoperative diagnosis of such hematomas using conventional methods is sometimes...
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Bicuspid reconstruction surgery in a patient suffering from aortic valve infective endocarditis with annular abscess using Ozaki's procedure: A case report. Int J Surg Case Rep. 2020 Oct 07;76:266-269 Authors: Ngo HT, Nguyen TT, Nguyen HC, Camilleri L, Thanh LN, Doan HQ Abstract INTRODUCTION: Aortic valve infective endocarditis with annular abscess is associated with high mortality rate and surgery is usually the choice of treatment. Plasty...
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Xanthogranuloma formation after endoscopic sinus surgery: A case report. Int J Surg Case Rep. 2020 Oct 02;76:263-265 Authors: Gu JH, Lee GH Abstract INTRODUCTION: Although xanthogranuloma is known to be related to trauma or mucosa, possibly developing around a periorbital or oral lesion, xanthogranuloma related to sinusitis urgery has not been reported. We present a case of xanthogranuloma formation after endoscopic sinus surgery (ESS). ...
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Iatrogenic pneumopericardium after tube thoracostomy: A case report. Int J Surg Case Rep. 2020 Oct 08;76:259-262 Authors: Mindaye ET, Arayia A, Tufa TH, Bekele M Abstract INTRODUCTION: Pneumopericardium, the presence of air within the pericardial space, is a rare occurrence which usually follows positive pressure ventilation in infants, or blunt and penetrating thoracoabdominal injuries in adults. The occurrence of iatrogenic pneumopericardium...
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Successful resection of a centrally located primary hepatic neuroendocrine tumor. Int J Surg Case Rep. 2020 Sep 30;76:254-258 Authors: Alakeel A, Alshamrani A, Alharbi A, Mubarah A, Alshurafa H, Aldayel M Abstract INTRODUCTION: Primary neuroendocrine tumors (NETs) of the liver are rare tumors that are challenging to diagnose. PRESENTATION OF CASE: A 41-year old woman presented with a four-month history of moderate abdominal pain in...
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A novel modified hanging maneuver in laparoscopic left hemihepatectomy. Int J Surg Case Rep. 2020 Oct 08;76:251-253 Authors: Takagi K, Umeda Y, Kuise T, Yoshida R, Yoshida K, Yasui K, Tani Y, Yagi T, Fujiwara T Abstract INTRODUCTION: The liver hanging maneuver is an essential technique for controlling bleeding in hepatectomy, however it is often difficult in laparoscopic major hepatectomy. The present study describes a novel modified hanging...
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Case report: Total enterectomy following complete small bowel ischaemia in the post-peritonectomy setting. Int J Surg Case Rep. 2020 Sep 23;76:247-250 Authors: Coulshed A, Soucisse M, Lansom JD, Morris D Abstract INTRODUCTION: This report presents the rare case of a patient with complete bowel ischaemia following parastomal hernia, leading to total bowel resection, with consideration of post-operative complications and wound management. ...
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Pancreaticoduodenectomy after distal gastrectomy: A case series. Int J Surg Case Rep. 2020 Oct 01;76:240-246 Authors: Fukuta M, Tomibayashi A, Tsuneki T, Nishioka K, Matsuo Y, Mori O, Fujiwara S, Yuasa Y Abstract INTRODUCTION: Pancreatoduodenectomy (PD) after gastrectomy requires more attention during surgery than ordinary PD due to anatomical variation with different types of gastrointestinal anastomoses, the complication of anatomical dissection,...
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A case of total spinal anesthesia. Int J Surg Case Rep. 2020 Sep 29;76:237-239 Authors: Asfaw G, Eshetie A Abstract INTRODUCTION: In situations where the time to delivery is urgent, but not critical within minutes, and otherwise contraindicated spinal anesthesia is the safer option of avoiding the risks and complications of general anesthesia, mainly difficult airway and risks of pulmonary aspiration. CASE PRESENTATION: A 35 years...
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Breast cancer patients with hormone neoadjuvant bridging therapy due to asymptomatic Corona virus infection. Case report, clinical and histopathologic findings. Int J Surg Case Rep. 2020 Oct 08;: Authors: Pellicciaro M, Granai AV, Marchese G, Materazzo M, Cotesta M, Santori F, Giacobbi E, Servadei F, Grelli S, Perretta T, Meucci R, Pistolese CA, Vanni G Abstract Introduction: Breast cancer management during COVID-19 pandemic has changed and...
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Statins decrease the expression of c-Myc protein in cancer cell lines. Mol Cell Biochem. 2020 Oct 17;: Authors: Rao PS, Rao US Abstract Statins are potent inhibitors of the mevalonate/cholesterol biosynthetic pathway and are widely prescribed for the prevention of cardiovascular diseases. Here, we carried out a comprehensive analysis of the effects of three statins, simvastatin, atorvastatin, and lovastatin, on six different cancer cell...
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Cytotoxicity of apigenin toward multiple myeloma cell lines and suppression of iNOS and COX-2 expression in STAT1-transfected HEK293 cells. Phytomedicine. 2020 Oct 08;80:153371 Authors: Adham AN, Abdelfatah S, Naqishbandi AM, Mahmoud N, Efferth T Abstract BACKGROUND: Apigenin is one of the most abundant dietary flavonoids that possesses multiple bio-functions. PURPOSE: This study was designed to determine the influence of apigenin...
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Synthesis and evaluation of new compounds bearing 3-(4-aminopiperidin-1-yl)methyl magnolol scaffold as anticancer agents for the treatment of non-small cell lung cancer via targeting autophagy. Eur J Med Chem. 2020 Oct 10;:112922 Authors: Zhao M, Zheng YH, Zhao QY, Zheng W, Yang JH, Pei HY, Liu L, Liu KJ, Xue LL, Deng DX, Wang L, Ma X, Fu SH, Peng AH, Tang MH, Luo YZ, Ye HY, Chen LJ Abstract Magnolol and honokiol are the two major active...
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The dual HDAC-PI3K inhibitor CUDC-907 displays single-agent activity and synergizes with PARP inhibitor olaparib in small cell lung cancer. J Exp Clin Cancer Res. 2020 Oct 17;39(1):219 Authors: Ma L, Bian X, Lin W Abstract BACKGROUND: Small cell lung cancer (SCLC) is a deadly neuroendocrine tumor with limited therapeutic options. Recent data suggest that histone deacetylases (HDACs) and the phosphatidylinositol 3-kinase (PI3K) pathway...
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Targeting cancer-cell mitochondria and metabolism to improve radiotherapy response. Transl Oncol. 2020 Oct 14;14(1):100905 Authors: McCann E, O'Sullivan J, Marcone S Abstract Radiotherapy is a regimen that uses ionising radiation (IR) to treat cancer. Despite the availability of several therapeutic options, cancer remains difficult to treat and only a minor percentage of patients receiving radiotherapy show a complete response to the treatment...
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Sodium-glucose co-transporter-2 (SGLT-2) inhibition reduces glucose uptake to induce breast cancer cell growth arrest through AMPK/mTOR pathway. Biomed Pharmacother. 2020 Oct 14;132:110821 Authors: Zhou J, Zhu J, Yu SJ, Ma HL, Chen J, Ding XF, Chen G, Liang Y, Zhang Q Abstract OBJECTIVE: The sodium-glucose transporter 2 (SGLT2) inhibitors Canagliflozin and Dapagliflozin are recently approved medications for type 2 diabetes. Recent studies...
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CAMK2N1 suppresses hepatoma growth through inhibiting E2F1-mediated cell-cycle signaling. Cancer Lett. 2020 Oct 14;: Authors: Peng JM, Tseng RH, Shih TC, Hsieh SY Abstract Human kinome/phosphatome screen identified CAMK2N1 genes suppressing the development of human hepatocellular carcinoma (HCC). CAMK2N1 downregulation was found in 47% HCCs and associated with poor prognosis. The downregulation was mainly attributed to its genome deletion...
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TMT-based quantitative proteomic analysis of antitumor mechanism of Sporisorium reilianum polysaccharide WM-NP-60 against HCT116 cells. Int J Biol Macromol. 2020 Oct 14;: Authors: Kan L, Cui D, Chai Y, Ma L, Li X, Zhao M Abstract Sporisorium reilianum is an active edible and medicinal phytopathogenic fungus. Our study indicated that the S. reilianum polysaccharide WM-NP-60 could inhibit the growth of HCT116 cells in a dose-dependent manner....
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Yangonin inhibits ethanol-induced hepatocyte senescence via miR-194/FXR axis. Eur J Pharmacol. 2020 Oct 14;:173653 Authors: Dong R, Wang X, Wang L, Wang C, Huang K, Fu T, Liu K, Wu J, Sun H, Meng Q Abstract Chronic alcohol assumption has been recognized as a major cause of alcoholic liver disease (ALD), which ranges from alcoholic steatohepatitis to fibrosis and hepatocellular carcinoma. Alcoholic liver disease has become the leading cause...
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Inhibition of CDK4/6 and autophagy synergistically induces apoptosis in t(8;21) acute myeloid leukemia cells. Int J Hematol. 2020 Oct 17;: Authors: Nakatani K, Matsuo H, Harata Y, Higashitani M, Koyama A, Noura M, Nishinaka-Arai Y, Kamikubo Y, Adachi S Abstract The t(8;21) translocation is the most common cytogenetic abnormality in acute myeloid leukemia (AML). Although t(8;21) AML patients have a relatively favorable prognosis, relapse...
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[Inhibitory Effects of Metformin on Proliferation of SKM-1 Cells and The Related Underlying Mechanisms]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2020 Oct;28(5):1654-1660 Authors: Zhou XJ, Liang SM, Wang L Abstract OBJECTIVE: To investigate the effects of metformin on the proliferation of AML-MDS cells (SKM-1 cells) and its related mechanisms. METHODS: CCK-8 was used to test the cell proliferation; Flow cytometry was used to detect...
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RNA binding RING E3-ligase DZIP3/hRUL138 stabilizes Cyclin D1 to drive cell cycle and cancer progression. Cancer Res. 2020 Oct 16;: Authors: Kolapalli SP, Sahu R, Chauhan NR, Jena KK, Mehto S, Das SK, Jain A, Rout M, Dash R, Swain RK, Lee DY, Rusten TE, Chauhan S, Chauhan S Abstract DZIP3/hRUL138 is a poorly characterized RNA binding RING E3-ubiquitin ligase with functions in embryonic development. Here we demonstrate that DZIP3 is a crucial...
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12-Deoxyphorbol Esters Induce Growth Arrest and Apoptosis in Human Lung Cancer A549 Cells Via Activation of PKC-δ/PKD/ERK Signaling Pathway. Int J Mol Sci. 2020 Oct 14;21(20): Authors: Tsai JY, Rédei D, Hohmann J, Wu CC Abstract Prostratin, a non-tumor promoting 12-deoxyphorbol ester, has been reported as a protein kinase C (PKC) activator and is shown to have anti-proliferative activity in certain cancer cell types. Here we show that...
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Targeting DNA Repair, Cell Cycle, and Tumor Microenvironment in B Cell Lymphoma. Cells. 2020 Oct 14;9(10): Authors: Bröckelmann PJ, de Jong MRW, Jachimowicz RD Abstract The DNA double-strand break (DSB) is the most cytotoxic lesion and compromises genome stability. In an attempt to efficiently repair DSBs, cells activate ATM kinase, which orchestrates the DNA damage response (DDR) by activating cell cycle checkpoints and initiating DSB...
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BmFoxO Gene Regulation of the Cell Cycle Induced by 20-Hydroxyecdysone in BmN-SWU1 Cells. Insects. 2020 Oct 14;11(10): Authors: Zhang Q, Yang J, Chen P, Liu T, Xiao Q, Zhou X, Wang L, Long Y, Dong Z, Pan M, Lu C Abstract Ecdysteroid titer determines the state of the cell cycle in silkworm (Bombyxmori) metamorphosis. However, the mechanism of this process is unclear. In this study, we demonstrated that the BmFoxO gene participates in the...
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Cannabinoid Combination Induces Cytoplasmic Vacuolation in MCF-7 Breast Cancer Cells. Molecules. 2020 Oct 14;25(20): Authors: Schoeman R, Beukes N, Frost C Abstract This study evaluated the synergistic anti-cancer potential of cannabinoid combinations across the MDA-MB-231 and MCF-7 human breast cancer cell lines. Cannabinoids were combined and their synergistic interactions were evaluated using median effect analysis. The most promising...
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Aneuploidy during the onset of mouse embryo development. Reproduction. 2020 Nov;160(5):773-782 Authors: Pauerova T, Radonova L, Kovacovicova K, Novakova L, Skultety M, Anger M Abstract Aneuploidy is the most frequent single cause leading into the termination of early development in human and animal reproduction. Although the mouse is frequently used as a model organism for studying the aneuploidy, we have only incomplete information about...
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New series of isoxazole derivatives targeting EGFR-TK: Synthesis, molecular modeling and antitumor evaluation. Bioorg Med Chem. 2020 Jul 28;28(21):115674 Authors: Warda ET, Shehata IA, El-Ashmawy MB, El-Gohary NS Abstract New series of isoxazole derivatives were synthesized and evaluated for in vitro antitumor activity against HepG2, MCF-7 and HCT-116 cancer cells. Results showed that 4b and 25a are the most potent members against the...
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Novel 2-amino-1,4-naphthoquinone hybrids: Design, synthesis, cytotoxicity evaluation and in silico studies. Bioorg Med Chem. 2020 Aug 28;28(21):115718 Authors: Gholampour M, Seradj H, Pirhadi S, Khoshneviszadeh M Abstract In the present work, a novel series of 2-amino-1,4-naphthoquinones bearing oxyphenyl moiety (5a-5m) were designed and synthesized via a two-step route and evaluated for their in vitro cytotoxic activity against three...
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The copper(II) complexes of new anthrahydrazone ligands: In vitro and in vivo antitumor activity and structure-activity relationship. J Inorg Biochem. 2020 Aug 09;212:111208 Authors: Liu RX, Wang CY, Wu YS, Luo RY, Jiang XH, Tang MT, Liu YC, Chen ZF, Liang H Abstract Two new copper(II) complexes, 9-PMAH-Cu (1) and 9-FPMAH-Cu (2), of anthrahydrazone were synthesized and structurally characterized, in which 9-FPMAH (9-(4'-trifluoromethyl)-pyrimidine...
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Discovery and in silico evaluation of aminoarylbenzosuberene molecules as novel checkpoint kinase 1 inhibitor determinants. Genomics. 2020 Oct 13;: Authors: Singh R, Bhardwaj VK, Sharma J, Das P, Purohit R Abstract CHK1 is an essential kinase with a critical function in cell cycle arrest. Several potent inhibitors targeting CHK1 have been published, but most of them have failed in clinical trials. Acknowledging the emerging consequence...
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Vanadium pentoxide nanoparticle mediated perturbations in cellular redox balance and the paradigm of autophagy to apoptosis. Free Radic Biol Med. 2020 Oct 13;: Authors: Suma PR, Padmanabhan RA, Telukutla SR, Ravindran R, Velikkakath AKG, Dekiwadia CD, Paul W, Laloraya M, Srinivasula SM, Bhosale SV, Jayasree RS Abstract The redox-active transition metals such as copper, iron, chromium, vanadium, and silica are known for its ROS generation...
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Synergistic apoptotic effects in cancer cells by the combination of CLK and Bcl-2 family inhibitors.
Synergistic apoptotic effects in cancer cells by the combination of CLK and Bcl-2 family inhibitors. PLoS One. 2020;15(10):e0240718 Authors: Murai A, Ebara S, Sasaki S, Ohashi T, Miyazaki T, Nomura T, Araki S Abstract Emerging evidence indicates that alternative splicing plays a critical role in cancer progression through abnormal expression or mutation of splicing factors. Small-molecule splicing modulators have recently attracted considerable...
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Recombinant human lactoferrin carrying humanized glycosylation exhibits antileukemia selective cytotoxicity, microfilament disruption, cell cycle arrest, and apoptosis activities. Invest New Drugs. 2020 Oct 16;: Authors: Nakamura-Bencomo S, Gutierrez DA, Robles-Escajeda E, Iglesias-Figueroa B, Siqueiros-Cendón TS, Espinoza-Sánchez EA, Arévalo-Gallegos S, Aguilera RJ, Rascón-Cruz Q, Varela-Ramirez A Abstract Lactoferrin has gained extensive...
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Chromodomain Helicase DNA-Binding Protein 5 Inhibits Renal Cell Carcinoma Tumorigenesis by Activation of the p53 and RB Pathways. Biomed Res Int. 2020;2020:5425612 Authors: Huang S, Yan Q, Xiong S, Peng Y, Zhao R, Liu C Abstract Chromodomain helicase DNA-binding protein 5 (CHD5) plays a crucial tumor suppressor role in multiple types of tumors. For this study, we investigated its clinical significance and the molecular mechanism(s) underlying...
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Transcriptome Changes in Colorectal Cancer Cells upon Treatment with Avicequinone B. Adv Pharm Bull. 2020 Sep;10(4):638-647 Authors: Ocampo Y, Caro D, Rivera D, Piermattey J, Gaitán R, Franco LA Abstract Purpose: Naphtho[2,3-b]furan-4,9-dione (Avicequinone B), a natural naphthoquinone isolated from the mangrove tree Avicennia alba , is recognized as a valuable synthetic precursor with anti-proliferative effect. However, the molecular mechanism...
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Isokotomolide A from Cinnamomum kotoense Induce Melanoma Autophagy and Apoptosis In Vivo and In Vitro. Oxid Med Cell Longev. 2020;2020:3425147 Authors: Li J, Chen CY, Huang JY, Wang L, Xu Z, Kang W, Lin MH, Wang HD Abstract Melanoma is an aggressive cancer with high lethality. In order to find new anticancer agents, isokotomolide A (Iso A) and secokotomolide A (Sec A) isolated from Cinnamomum kotoense were identified to be potential bioactive...
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Upregulation of miR-361-3p suppresses serotonin-induced proliferation in human pulmonary artery smooth muscle cells by targeting SERT. Cell Mol Biol Lett. 2020;25:45 Authors: Zhang Y, Chen Y, Chen G, Zhou Y, Yao H, Tan H Abstract Background: Abnormal proliferation of pulmonary artery smooth muscle cells (PASMCs) is a key mechanism in pulmonary arterial hypertension (PAH). Serotonin (5-hydroxytryptamine, 5-HT) can induce abnormal proliferation...
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Synthesis of Amino Acid Schiff Base Nickel (II) Complexes as Potential Anticancer Drugs In Vitro. Bioinorg Chem Appl. 2020;2020:8834859 Authors: Li Y, Dong J, Zhao P, Hu P, Yang D, Gao L, Li L Abstract Three hexacoordinated octahedral nickel (II) complexes, [Ni (Trp-sal) (phen) (CH3OH)] (1), [Ni (Trp-o-van) (phen) (CH3OH)]•2CH3OH (2), and [Ni (Trp-naph) (phen) (CH3OH)] (3) (where Trp-sal = Schiff base derived from tryptophan and salicylaldehyde,...
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Novel sequential treatment with palbociclib enhances the effect of cisplatin in RB-proficient triple-negative breast cancer. Cancer Cell Int. 2020;20:501 Authors: Huang Y, Wu H, Li X Abstract Background: Triple-negative breast cancer (TNBC) is a highly aggressive malignancy that lacks sensitivity to chemotherapy, endocrine therapy or targeted therapy. CDK4/6 inhibitors, combined with endocrine therapy, have been shown to be effective in...
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miR-550-1 functions as a tumor suppressor in acute myeloid leukemia via the hippo signaling pathway.
miR-550-1 functions as a tumor suppressor in acute myeloid leukemia via the hippo signaling pathway. Int J Biol Sci. 2020;16(15):2853-2867 Authors: Hu C, Yu M, Li C, Wang Y, Li X, Ulrich B, Su R, Dong L, Weng H, Huang H, Jiang X, Chen J, Jin J Abstract MicroRNAs (miRNAs) and N6-methyladenosine (m6A) are known to serve as key regulators of acute myeloid leukemia (AML). Our previous microarray analysis indicated miR-550-1 was significantly...
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TCEAL2 as a Tumor Suppressor in Renal Cell Carcinoma is Associated with the Good Prognosis of Patients. Cancer Manag Res. 2020;12:9589-9597 Authors: Zhou Y, Zhang Y, Li W, Xu J, He X, Li X, Wang Y Abstract Background: Renal cell carcinoma (RCC) is one of the most common tumors in urinary tract tumors. However, the mechanism that supports renal cell carcinoma is unclear. The function of transcription elongation factor A (SII)-like 2 (TCEAL2)...
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CircCSNK1G1 Contributes to the Development of Colorectal Cancer by Increasing the Expression of MYO6 via Competitively Targeting miR-455-3p. Cancer Manag Res. 2020;12:9563-9575 Authors: Huang X, Shen X, Peng L, Mai W, Wan Y, Zhang H Abstract Background: Numerous circular RNAs (circRNAs) are functionally investigated in various human cancers, including colorectal cancer (CRC). In this study, we explored the function of circCSNK1G1 and mechanism...
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EphA5 Silencing Increases the Radiosensitivity of ESCC Cells Through ATM-Dependent Pathway. Cancer Manag Res. 2020;12:9539-9549 Authors: Zhang R, Han D, Li L, Luo W, Liu J, Qian L Abstract Background: Radiotherapy is one of the most important treatments for esophageal squamous cell carcinoma (ESCC). Previously, we found that EphA5 expression was increased in ESCC cells and tumor tissues. Studies from other groups reported that EphA5 is...
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Hsa_circ_0084927 Regulates Cervical Cancer Advancement via Regulation of the miR-634/TPD52 Axis. Cancer Manag Res. 2020;12:9435-9448 Authors: Shi P, Zhang X, Lou C, Xue Y, Guo R, Chen S Abstract Background: Cervical cancer (CC) is a common gynecological tumor that affects women's health. Circular RNA hsa_circ_0084927 (hsa_circ_0084927) has been reported to be upregulated in CC. However, the role and regulatory mechanism of hsa_circ_0084927...
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Circ_0084927 Facilitates Cervical Cancer Development via Sponging miR-142-3p and Upregulating ARL2. Cancer Manag Res. 2020;12:9271-9283 Authors: Chen L, Zhang X, Wang S, Lin X, Xu L Abstract Background: Cervical cancer is a fatal burden for women. Circular RNAs (circRNAs) are important regulators in cancer development. Our study aimed to investigate the function and action mechanism of a novel circRNA, circ_0084927, in cervical cancer....
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The Hsa_circ_0091579/miR-940/TACR1 Axis Regulates the Development of Hepatocellular Carcinoma. Cancer Manag Res. 2020;12:9087-9096 Authors: Jiang P, Han W, Fu Y, Chen Q Abstract Purpose: Circular RNAs (circRNAs) play important roles in hepatocellular carcinoma (HCC) development. The circRNA hsa_circ_0091579 (circ_0091579) is dysregulated in HCC, while the mechanism of circ_0091579 in HCC development is largely unknown. Patients...
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Identification of a Novel c-Myc Inhibitor 7594-0037 by Structure-Based Virtual Screening and Investigation of Its Anti-Cancer Effect on Multiple Myeloma. Drug Des Devel Ther. 2020;14:3983-3993 Authors: Yao R, Xie Y, Sun X, Zhang M, Zhou J, Liu L, Gao J, Xu K Abstract Introduction: Multiple myeloma (MM) is an extremely malignant and incurable hematological cancer. Increased expression of the c-Myc oncoprotein is closely associated with...
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Knockdown of hsa_circ_0059955 Induces Apoptosis and Cell Cycle Arrest in Nucleus Pulposus Cells via Inhibiting Itchy E3 Ubiquitin Protein Ligase. Drug Des Devel Ther. 2020;14:3951-3963 Authors: Kong D, Gu R, Zhang C, Yin R Abstract Background: Circular RNAs (circRNAs) play an important role in the progression of intervertebral disc (IVD) degeneration (IVDD). Using bioinformatics analysis, we have found that the expression of circRNA hsa_circ_0059955...
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HOPS/Tmub1 involvement in the NF-kB-mediated inflammatory response through the modulation of TRAF6. Cell Death Dis. 2020 Oct 15;11(10):865 Authors: Bellet MM, Pieroni S, Castelli M, Piobbico D, Fallarino F, Romani L, Della-Fazia MA, Servillo G Abstract HOPS/Tmub1 is a ubiquitously expressed transmembrane ubiquitin-like protein that shuttles between nucleus and cytoplasm during cell cycle progression. HOPS causes cell cycle arrest in G0/G1...
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UHRF1 knockdown attenuates cell growth, migration, and invasion in cutaneous squamous cell carcinoma. Cancer Invest. 2020 Oct 15;:1-26 Authors: Li Q, Chu Z, Geng S Abstract Ubiquitin like with PHD and ring finger domains 1 (UHRF1) contributes to the progression of many cancers. Here, we firstly observed UHRF1 was elevated in cutaneous squamous cell carcinoma (cSCC) and related to the differentiation stages. Knockdown of UHRF1 in A431 and...
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Cellular senescence contributes to radiation-induced hyposalivation by affecting the stem/progenitor cell niche. Cell Death Dis. 2020 Oct 14;11(10):854 Authors: Peng X, Wu Y, Brouwer U, van Vliet T, Wang B, Demaria M, Barazzuol L, Coppes RP Abstract Radiotherapy for head and neck cancer is associated with impairment of salivary gland function and consequent xerostomia, which has a devastating effect on the quality of life of the patients....
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Metallophosphoesterase 1, a novel candidate gene in hepatocellular carcinoma malignancy and recurrence. Cancer Biol Ther. 2020 Oct 15;:1-9 Authors: Chen X, Xu J, Wang P, Shang L, Guo J, Huang L, Jiang YA, Chen J, Chen H, Shang Y, Zhang Q Abstract BACKGROUND: There is an unmet need to identify novel mechanism-based prognostic genes associated with hepatocellular carcinoma (HCC) recurrence that can predict patient outcomes and provide therapeutic...
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Translation of Tudor-SN, a novel terminal oligo-pyrimidine (TOP) mRNA, is regulated by the mTORC1 pathway in cardiomyocytes. RNA Biol. 2020 Oct 15;:1-14 Authors: Gan S, Su C, Ma J, Liu M, Cui X, Xin L, Ren Y, Gao X, Ge L, Wei M, Yang J Abstract The mechanisms that regulate cell-cycle arrest of cardiomyocytes during heart development are largely unknown. We have previously identified Tudor staphylococcal nuclease (Tudor-SN) as a cell-cycle...
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Terminalia bentzoë, a Mascarene Endemic Plant, Inhibits Human Hepatocellular Carcinoma Cells Growth In Vitro via G0/G1 Phase Cell Cycle Arrest. Pharmaceuticals (Basel). 2020 Oct 12;13(10): Authors: Rummun N, Rondeau P, Bourdon E, Pires E, McCullagh J, Claridge TDW, Bahorun T, Li WW, Neergheen VS Abstract Tropical forests constitute a prolific sanctuary of unique floral diversity and potential medicinal sources, however, many of them remain...
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Circular RNA 0086996 regulates growth and migration of osteosarcoma cells via miR-125b-5p. Pathol Res Pract. 2020 Sep 25;216(11):153230 Authors: Luo Z, Yang Y, Li D, Yu L, Liu N, Li L, Ma Y Abstract Circular RNAs (CircRNAs) have been found to be critical in tumorigenesis; however, the role of CircRNAs in osteosarcoma is to be further studied. In this study, we preliminarily identified the up-expressed CircRNAs and its downstream microRNA...
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Rucaparib Treatment Alters p53 Oscillations in Single Cells to Enhance DNA-Double-Strand-Break-Induced Cell Cycle Arrest. Cell Rep. 2020 Oct 13;33(2):108240 Authors: Hanson RL, Batchelor E Abstract DNA double strand breaks induce oscillatory expression of the transcription factor p53 that is dependent on ataxia telangiectasia mutated (ATM) activity and the rate of double strand break resolution. Although p53 dynamics are known to play...
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Syt-7 overexpression predicts poor prognosis and promotes cell proliferation in hepatocellular carcinoma. Future Oncol. 2020 Oct 14;: Authors: Jin H, Pang Q, Fang M, Wang Y, Man Z, Tan Y, Liu H Abstract Aim: To explore the prognostic significance of Syt-7 in hepatocellular carcinoma (HCC) and the potential mechanisms. Methods: Immunohistochemistry was used to examine the expression of Syt-7. Overall survival and disease-free survival were...
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Targeting BCL10 by small peptides for the treatment of B cell lymphoma. Theranostics. 2020;10(25):11622-11636 Authors: Bao W, Sun C, Sun X, He M, Yu H, Yan W, Wen F, Zhang L, Yang C Abstract Rationale: Constitutive activation of the NF-κB signalling pathway plays a pivotal role in the pathogenesis of activated B cell-like diffuse large B-cell lymphomas (ABC-DLBCLs), the most aggressive and chemoresistant form of DLBCL. In ABC-DLBCLs, the...
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Release from cell cycle arrest with Cdk4/6 inhibitors generates highly synchronized cell cycle progression in human cell culture. Open Biol. 2020 Oct;10(10):200200 Authors: Trotter EW, Hagan IM Abstract Each approach used to synchronize cell cycle progression of human cell lines presents a unique set of challenges. Induction synchrony with agents that transiently block progression through key cell cycle stages are popular, but change stoichiometries...
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Immunotherapy in gastroesophageal cancers: Current state and future directions. J Oncol Pharm Pract. 2020 Oct 13;:1078155220963538 Authors: Shaikh H, Kamran A, Monga DK Abstract While gastroesophageal (GE) cancers are one of the most common cancers worldwide, unfortunately, the mortality remains high. Commonly used treatment options include surgical resection, chemotherapy, radiotherapy, and molecular targeted therapy, which improve survival...
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Patient-Derived, Drug-Resistant Colon Cancer Cells Evade Chemotherapeutic Drug Effects via the Induction of Epithelial-Mesenchymal Transition-Mediated Angiogenesis. Int J Mol Sci. 2020 Oct 10;21(20): Authors: Lim JH, Choi KH, Kim SY, Park CS, Kim SM, Park KC Abstract Cancer cells can exhibit resistance to different anticancer drugs by acquiring enhanced anti-apoptotic potential, improved DNA injury resistance, diminished enzymatic inactivation,...
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Efficacy of HDAC Inhibitors Belinostat and Panobinostat against Cisplatin-Sensitive and Cisplatin-Resistant Testicular Germ Cell Tumors. Cancers (Basel). 2020 Oct 10;12(10): Authors: Lobo J, Guimarães-Teixeira C, Barros-Silva D, Miranda-Gonçalves V, Camilo V, Guimarães R, Cantante M, Braga I, Maurício J, Oing C, Honecker F, Nettersheim D, Looijenga LH, Henrique R, Jerónimo C Abstract Novel treatment options are needed for testicular germ...
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Recombinant Bacillus caldovelox Arginase Mutant (BCA-M) Induces Apoptosis, Autophagy, Cell Cycle Arrest and Growth Inhibition in Human Cervical Cancer Cells. Int J Mol Sci. 2020 Oct 09;21(20): Authors: Chung SF, Kim CF, Chow HY, Chong HC, Tam SY, Leung YC, Lo WH Abstract With our recent success in developing a recombinant human arginase drug against broad-spectrum cancer cell lines, we have explored the potential of a recombinant Bacillus...
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Related Articles Targeting cell cycle by β-carboline alkaloids in vitro: Novel therapeutic prospects for the treatment of cancer. Chem Biol Interact. 2020 Oct 01;330:109229 Authors: Ahmad I, Fakhri S, Khan H, Jeandet P, Aschner M, Yu ZL Abstract Cell cycle dysregulation is the mainstay of aberrant cell proliferation, which leads to tumor progression. Mutations in tumor cells initiate various dysregulated pathways and spontaneous over-proliferation...
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Related Articles Circ_0010220-mediated miR-503-5p/CDCA4 axis contributes to osteosarcoma progression tumorigenesis. Gene. 2020 Dec 30;763:145068 Authors: Li J, Zhang F, Li H, Peng F, Wang Z, Peng H, He J, Li Y, He L, Wei L Abstract CircRNAs are reported to exert a significant role in modulating genes in cancers, including osteosarcoma progression. Up to now, the function of circ_0010220 in osteosarcoma is still poorly known. The aim of our...
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Related Articles The role of substance P/neurokinin 1 receptor in the pathogenesis of esophageal squamous cell carcinoma through constitutively active PI3K/Akt/NF-κB signal transduction pathways. Mol Biol Rep. 2020 Mar;47(3):2253-2263 Authors: Javid H, Asadi J, Zahedi Avval F, Afshari AR, Hashemy SI Abstract One of the most prevalent malignancies is esophageal squamous cell carcinoma (ESCC), which is associated with high morbidity and mortality....
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Related Articles Silencing of long‑chain non‑coding RNA GAS5 in osteoarthritic chondrocytes is mediated by targeting the miR‑34a/Bcl‑2 axis. Mol Med Rep. 2020 Mar;21(3):1310-1319 Authors: Ji Q, Qiao X, Liu Y, Wang D, Yan J Abstract The present study aimed to investigate the effects of the long non‑coding RNA (lncRNA) growth arrest‑specific transcript 5 (GAS5) on proliferation, apoptosis and the inflammatory response of osteoarthritic chondrocytes...
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Related Articles Inhibition of PIM2 in liver cancer decreases tumor cell proliferation in vitro and in vivo primarily through the modulation of cell cycle progression. Int J Oncol. 2020 Feb;56(2):448-459 Authors: Kronschnabl P, Grünweller A, Hartmann RK, Aigner A, Weirauch U Abstract Liver cancer is the fourth leading cause of cancer‑related mortality worldwide with limited therapeutic options. Thus, novel treatment strategies are urgently...
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Related Articles Bcl2l10 mediates the proliferation, invasion and migration of ovarian cancer cells. Int J Oncol. 2020 Feb;56(2):618-629 Authors: Lee SY, Kwon J, Woo JH, Kim KH, Lee KA Abstract Bcl2l10, also known as Diva, Bcl‑b and Boo, is a member of the Bcl2 family of proteins, which are involved in signaling pathways that regulate cell apoptosis and autophagy. Previously, it was demonstrated that Bcl2l10 plays a crucial role in the...
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Related Articles Carnosine exerts antitumor activity against bladder cancers in vitro and in vivo via suppression of angiogenesis. J Nutr Biochem. 2019 12;74:108230 Authors: Hwang B, Shin SS, Song JH, Choi YH, Kim WJ, Moon SK Abstract Carnosine, a naturally occurring dipeptide, was recently reported to exhibit anticancer activity; however, the molecular mechanisms and regulators underlying its activity against tumor-associated angiogenesis...
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Related Articles Omega-3 polyunsaturated fatty acids suppress metastatic features of human cholangiocarcinoma cells by suppressing twist. J Nutr Biochem. 2019 12;74:108245 Authors: Lin CR, Chu TM, Luo A, Huang SJ, Chou HY, Lu MW, Wu JL Abstract Cholangiocarcinoma (CCA) is a highly malignant cancer of the bile duct, which has a five-year survival rate less than 5% due to a high metastasis rate and lack of therapeutic options. Although omega-3...
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Related Articles Short exposure to cold atmospheric plasma induces senescence in human skin fibroblasts and adipose mesenchymal stromal cells. Sci Rep. 2019 06 17;9(1):8671 Authors: Bourdens M, Jeanson Y, Taurand M, Juin N, Carrière A, Clément F, Casteilla L, Bulteau AL, Planat-Bénard V Abstract Cold Atmospheric Plasma (CAP) is a novel promising tool developed in several biomedical applications such as cutaneous wound healing or skin cancer....
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Related Articles Thallium(I) treatment induces nucleolar stress to stop protein synthesis and cell growth. Sci Rep. 2019 05 06;9(1):6905 Authors: Chou YT, Lo KY Abstract Thallium is considered as an emergent contaminant owing to its potential use in the superconductor alloys. The monovalent thallium, Tl(I), is highly toxic to the animals as it can affect numerous metabolic processes. Here we observed that Tl(I) decreased protein synthesis...
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Assessment of transient cerebral hemodynamic disturbance via Whole brain CT perfusion following extracranial-intracranial bypass in ischemic moyamoya disease. World Neurosurg. 2020 Oct 15;: Authors: Yao F, Han Q, Zhang Z, Huang Y Abstract OBJECTIVE: To assess the cerebral hemodynamic data associated with transient cerebral hemodynamic disturbance (TCHD, including cerebral hyper-perfusion syndrome (CHS) and Watershed shift ischemia (WSI), by...
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Open microvascular thrombectomy for acute intracranial large vessel occlusion: Microsurgery in the endovascular thrombectomy era. World Neurosurg. 2020 Oct 14;: Authors: Gautam AT, Seh H, Jain A, Mechri I, Jan van Doormaal P, Dammers R, Volovici V Abstract Open microsurgical thrombectomy for acute intracranial large vessel occlusion (LVO) has been the subject of dozens of case reports and series. Up to date, however, no clear indications exist...
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Impact of Surgical Approaches on Complications, ER-admissions and HealthCare Utilization in Patients Undergoing Lumbar Fusions for Degenerative Disc Diseases: A MarketScan Database Analysis. World Neurosurg. 2020 Oct 14;: Authors: Sharma M, Dietz N, John K, Aljuboori Z, Wang D, Ugiliweneza B, Boakye M, Drazin D Abstract OBJECTIVE: To Identify the impact of different surgical approaches for lumbar degenerative disc disease (DDD) on complications,...
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Deconstructive endovascular treatment of ruptured serpentine basilar artery aneurysm by mid-basilar occlusion: a case report. World Neurosurg. 2020 Oct 14;: Authors: Mizuno H, Wakabayashi K, Shimizu T, Tomita Y, Koga H, Yoshimoto Y Abstract BACKGROUND: No clear treatment course for cerebral aneurysms in the main trunk of the basilar artery has been established thus far. CASE DESCRIPTION: A 69-year-old man with a history of hypertension...
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'Apoplectic' recurrence of massive trigeminal neurinomas: report of seven cases. World Neurosurg. 2020 Oct 14;: Authors: Goel A, Jadhav N, Shah A, Rai S, Vutha R, Dandpat S Abstract OBJECTIVE: The pattern of recurrence of large trigeminal neurinomas is analyzed on the basis of experience with 7 cases. METHODS: This is a report of 7 cases of large trigeminal neurinomas that were operated on an average 11 years earlier. After being relatively...
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Differences by Practice Year in Numbers of U.S. Female Neurosurgeons. World Neurosurg. 2020 Oct 14;: Authors: De La Peña NM, Richter KR, Haglin JM, Pollock JR, Richter RA, Kouloumberis PE Abstract OBJECTIVE: To determine the proportion and number of female neurosurgeons in the workforce at different stages of practice. METHODS: The Physician Compare National Downloadable File data set was obtained from the Centers for Medicare &...
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Surgery vs Radiofrequency Ablation in the Management of Spinal Osteoid Osteomas: A Spine Oncology Referral Centre Comparison Analysis of 138 cases. World Neurosurg. 2020 Oct 14;: Authors: Pipola V, Tedesco G, Spinnato P, Facchini G, Gala RB, Bandiera S, Bròdano GB, Terzi S, Ghermandi R, Evangelisti G, Ricci A, Griffoni C, Pezzi A, Gasbarrini A Abstract BACKGROUND: Osteoid Osteomas (OOs) are benign bone forming tumours that, usually, occur in...
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The safety of deep brain stimulation lead placement on patients requiring anti-clotting therapies. World Neurosurg. 2020 Oct 14;: Authors: Topp G, Ghulam-Jelani Z, Chockalingam A, Kumar V, Byraju K, Sukul V, Pilitsis JG Abstract BACKGROUND: Limited studies exist to support the safety of performing neuromodulation surgeries in patients whose anticlotting medication has been held. Here, we assess the safety of performing deep brain stimulation...
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WHICH OBJECTIVE NUTRITIONAL INDEX IS BETTER FOR THE PREDICTION OF ADVERSE MEDİCAL EVENTS IN ELDERLY PATIENTS UNDERGOING SPINAL SURGERY. World Neurosurg. 2020 Oct 14;: Authors: Acarbaş A, Serdar N Abstract OBJECTIVE: The relation of preoperative malnutrition with perioperative complications has not been well studied in elderly patients undergoing spinal surgery (SS). Therefore, we aimed to compare the value of prognostic nutritional index (PNI),...
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Geospatial Distribution of Neurosurgeons Age 60 and Above Relative to the Spread of COVID-19. World Neurosurg. 2020 Oct 13;: Authors: Jella TK, Desai A, Jella T, Steinmetz M, Kimmell K, Wright J, Wright CH, in affiliation with the Council of State Neurosurgical Societies (CSNS) Abstract OBJECTIVE: To perform an ecological study in order to analyze the geospatial distribution of neurosurgeons ≥ 60 years old and compare these data with the spread...
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Typical and atypical radiographic features of symptomatic osteoblastoma in the spine. World Neurosurg. 2020 Oct 13;: Authors: Chen K, Tian C, Yang S, Han S, Jiang L, Wei F, Yuan H, Liu X, Liu Z Abstract PURPOSE: Spine osteoblastomas (OBs) are relatively rare. Unlike osteoid osteoma (OO), radiological and clinical manifestations of OB can be varied and atypical. Typical radiographic features in spinal OB include peritumoral bone sclerosis, bone...
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An Evaluation of Neurosurgical Practices During the COVID-19 Pandemic. World Neurosurg. 2020 Oct 13;: Authors: Pelargos PE, Chakraborty AR, Adogwa O, Swartz K, Zhao YD, Smith ZA, Dunn IF, Bauer AM Abstract OBJECTIVE: To understand how the COVID-19 pandemic has affected the neurosurgical workforce. METHODS: A survey consisting of twenty-two questions assessing respondent's operative experience, location, type of practice, subspecialty,...
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Application of Ultrasonic Doppler Technology Based on Wavelet Threshold Denoising Algorithm in Fetal Heart Rate and Central Nervous System Malformation Detection. World Neurosurg. 2020 Oct 13;: Authors: Yan Z, Xu X, Wang Y, Li T, Ma B, Yang L, Lu Y, Li Q Abstract This paper discusses the clinical value of standardized early pregnancy ultrasound structure screening in the diagnosis of fetal central nervous system malformations. In this paper,...
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Early Effects of COVID-19 Pandemic on Neurosurgical Training in the United States: A Case Volume Analysis of Eight Programs. World Neurosurg. 2020 Oct 13;: Authors: Aljuboori ZS, Young CC, Srinivasan VM, Kellogg RT, Quon JL, Alshareef MA, Chen SH, Ivan M, Grant GA, McEvoy SD, Davanzo JR, Majid S, Durfy S, Levitt MR, Sieg EP, Ellenbogen RG, Nauta HJ Abstract OBJECTIVE: The objective was to determine the impact of the COVID-19 pandemic on operative...
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Clinical Results and Complications of Endoscopic Lumbar Interbody Fusion for Lumbar Degenerative Disease: A Meta-Analysis. World Neurosurg. 2020 Oct 13;: Authors: Heo DH, Lee DC, Kim HS, Park CK, Chung H Abstract BACKGROUND: Although endoscopic transforaminal lumbar interbody fusion (TLIF) may combine the advantages of minimally invasive fusion and endoscopic spine surgery, little evidence exists on endoscopic TLIF. This meta-analysis investigated...
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Demonstration of Microsurgical Technique and Nuances for the Obliteration of Complex Intracranial Dural Arteriovenous Fistulas in Three Consecutive Cases: Operative Video. World Neurosurg. 2020 Oct 13;: Authors: Soylemez B, Turan Y, Sayyahmelli S, Başkaya MK Abstract An intracranial dural arteriovenous fistula (DAVF) is an uncommon acquired dural shunt between an artery and a vein without a parenchymal nidus. DAVF occlusion may be achieved...
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Outcomes after decompressive craniectomy for ischemic stroke: a volumetric analysis. World Neurosurg. 2020 Oct 13;: Authors: Parish JM, Asher AM, Pfortmiller D, Smith MD, Clemente JD, Stetler WR, Bernard JD Abstract BACKGROUND: Decompressive hemicraniectomy (DHC) is a treatment of space-occupying hemispheric infarct. Current surgical guidelines use criteria of age less than 60 and surgery within 48 hours of stroke onset. OBJECTIVE:...
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Frailty and Outcomes after Craniotomy or Craniectomy for Atraumatic Chronic Subdural Hematoma. World Neurosurg. 2020 Oct 13;: Authors: Sastry RA, Pertsch N, Tang O, Shao B, Toms SA, Weil RJ Abstract INTRODUCTION: Frailty is a measure of decreased physiologic reserve and has been associated with increased morbidity and mortality in a variety of surgical disciplines. No data exist regarding the relationship of frailty with adverse outcomes in...
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Surgical treatment of chronic subdural haematomas in nonagenarians: who to treat? World Neurosurg. 2020 Oct 13;: Authors: Ewbank F, Durnford A, Akarca D, Sadek AR, Hempenstall J Abstract OBJECTIVE: While chronic subdural haematomas (cSDH) are often treated surgically, it remains plausible that invasive treatment in elderly patients may have a negative effect on survival. The aim of this study was to characterise survival following neurosurgical...
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Effect of abdominal aortic balloon occlusion timing on femoral nerve injury in patients with dangerous placenta preview based on color dropper ultrasound images. World Neurosurg. 2020 Oct 13;: Authors: Zheng X, Li X, Xu J, Wei Y Abstract Herein is blocked by color doppler ultrasound image of the abdominal aorta balloon actual determination. The danger preview was effected by pathological diagnosis and surgery before dangerous type of implacable....
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A Novel Parameter to Predict Supraclinoid Aneurysm Persistence After Flow Diversion with the Pipeline Embolization Device. World Neurosurg. 2020 Oct 13;: Authors: Muram S, Eesa M, Belanger BL, Almekhlafi M, Goyal M, Morrish W, Wong JH, Gomez-Paz S, Akamatsu Y, Salem MM, Robinson TM, Moore JM, Thomas AJ, Ogilvy CS, Mitha AP Abstract BACKGROUND: Aneurysm recurrence after Pipeline Embolization Device (PED) placement can be caused by oversizing...
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CT Image Analysis of Neuromuscular Electrical Stimulation in the Treatment of Knee Osteoarthritis with Different Radiological Characteristics Based on Iterative Reconstruction Algorithm. World Neurosurg. 2020 Oct 12;: Authors: Xing W, Cai M, Li C, Nie Z, Tang W Abstract The paper uses CT image analysis of iterative reconstruction algorithm to understand the effect of neuromuscular electrical stimulation of quadriceps on motor function rehabilitation...
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Workplace Violence and Neurosurgery: Insights from a Nationwide Survey. World Neurosurg. 2020 Oct 12;: Authors: Schmidt T, Susa S, Pieters T, Tomlinson S, Rosenow JM, Kimmell K, Phelps JT, In affiliation with the Council of State Neurosurgical Societies (CSNS) Abstract OBJECTIVE: Workplace violence (WPV) against neurosurgeons is an understudied phenomenon, as prior research has focused on high-risk specialties like emergency medicine and psychiatry....
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Atypical course of vertebral artery outside the cervical spine - case report and literature review. World Neurosurg. 2020 Oct 12;: Authors: Siedlecki Z, Szostak M, Nowak K, Śniegocki M PMID: 33059082 [PubMed - as supplied by publisher]
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Intraoperative Thrombolysis of Massive Pulmonary Embolus During Spine Surgery: Case Report of Survival Complicated by Massive Bleeding and Review of the Literature. World Neurosurg. 2020 Oct 12;: Authors: Holland R, Houten JK, Elsamragy S, Kim J, Leyvi G, Kinon MD Abstract Pulmonary embolism (PE) is a known risk of lumbar spinal fusion surgery that can lead to sudden and unexpected death. Treatment often involves systemic anticoagulation when...
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Mazor X Stealth Robotic Technology: A Technical Note. World Neurosurg. 2020 Oct 12;: Authors: O'Connor TE, O'Hehir MM, Khan A, Mao JZ, Levy LC, Mullin JP, Pollina J PMID: 33059080 [PubMed - as supplied by publisher]
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Changing Hands: A Rising Role of the Tumor Surgeon in Teaching Sylvian Fissure Dissection. World Neurosurg. 2020 Oct 12;: Authors: Bowden SG, Siler DA, Radu S, Woll C, Rae AI, Cheaney B, Nugent JG, Stedelin B, Cetas JS, Dogan A, Han SJ PMID: 33059079 [PubMed - as supplied by publisher]
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An optimized Enhanced Recovery After Surgery (ERAS) pathway improved patient care in adolescent idiopathic scoliosis surgery: a retrospective cohort study. World Neurosurg. 2020 Oct 12;: Authors: Yang YJ, Huang X, Gao XN, Xia B, Gao JB, Wang C, Zhu XL, Shi XJ, Tao HR, Luo ZJ, Huang JH Abstract OBJECTIVE: A optimized enhanced recovery after surgery (ERAS) is lacking for adolescent idiopathic scoliosis (AIS). The aim of the present study was...
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331 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: head and neck These pubmed results were generated on 2020/10/19PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Strategies for restarting Pediatric Otolaryngology outpatient clinics after a pandemic-related shutdown such as from COVID-19. Int J Pediatr Otorhinolaryngol. 2020 Oct 01;139:110414 Authors: Leitmeyer K, Felton M, Chadha NK Abstract The novel coronavirus 19 SARS-CoV2 caused a change in the practice of Otolaryngology around the globe. The high viral load in the nasal cavity, nasopharynx and airway subjects Otolaryngologists to a high risk of...
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Comparisons of performance in pediatric bone conduction implant recipients using remote microphone technology. Int J Pediatr Otorhinolaryngol. 2020 Oct 11;139:110444 Authors: Snapp H, Morgenstein K, Sanchez C, Coto J, Cejas I Abstract OBJECTIVES: For children with hearing loss, remote microphone (RM) technology can significantly improve access to speech in environments with poor signal-to-noise ratios (SNRs), such as classrooms. Yet, this has...
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Isolated hyoid bone fracture in a child due to a fall. Int J Pediatr Otorhinolaryngol. 2020 Oct 12;139:110443 Authors: Chainchel Singh MK, Siew SF, Lai PS Abstract Hyoid bone fractures due to blunt trauma are rare accounting for only 0.002% of all head and neck fractures with most documented fractures being due to strangulation, hanging, motorcycle helmet straps, sports injuries and rarely as a complication of intubation. However, they are...
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Management of pediatric laryngeal webs secondary to severe croup and traumatic intubation. Int J Pediatr Otorhinolaryngol. 2020 Oct 13;139:110409 Authors: Waler A, Sanchez K, Cervantes SS, Chen C Abstract Laryngotracheobronchitis is a common, typically self-limiting viral infection. However, severe laryngotracheobronchitis can require urgent intubation to prevent imminent airway obstruction. The concurrent inflammation and urgency make laryngeal...
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Yield of preoperative findings in pediatric airway foreign bodies - A meta-analysis. Int J Pediatr Otorhinolaryngol. 2020 Oct 13;139:110442 Authors: Zoizner-Agar G, Merchant S, Wang B, April MM Abstract IMPORTANCE: Foreign body (FB) aspiration into the airway is a significant cause of pediatric morbidity and mortality, yet the clinical presentation is diverse and dynamic. There are conflicting recommendations which pre-procedural findings support...
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Congenital nasolacrimal duct obstruction update study (CUP study): Paper II - Profile and outcomes of complex CNLDO and masquerades. Int J Pediatr Otorhinolaryngol. 2020 Sep 28;139:110407 Authors: Bansal O, Bothra N, Sharma A, Ali MJ Abstract OBJECTIVE: To assess the profiles and outcomes of complex congenital nasolacrimal duct obstruction (C-CNLDO). METHODS: Retrospective interventional case-series was performed on patients diagnosed...
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The concatenation of association between gastroesophageal reflux and obstructive adenotonsillar hypertrophy. Int J Pediatr Otorhinolaryngol. 2020 Oct 10;139:110439 Authors: Sagar M, Sagar P, Kabra SK, Kumar R, Mallick S Abstract OBJECTIVES: Gastroesophageal reflux (GER) is frequently seen in patients with adenotonsillar hypertrophy. However, the sequential association between GER and adenotonsillar hypertrophy is unknown. This leads to unpredictable...
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Image-guided surgical navigation for bone-conduction hearing device implant placement. Int J Pediatr Otorhinolaryngol. 2020 Sep 29;139:110392 Authors: Shih M, Gitomer SA, Barton G, Liu YC Abstract INTRODUCTION: For pediatric patients, bone-conduction hearing devices (BCHD) have demonstrated excellent outcomes. Unique to this population, BCHD implant surgeries can be technically challenging in children due to thinner, developing bone and syndromes...
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Choices in deaf education and cochlear implantation: Suggesting a more inclusive approach. Int J Pediatr Otorhinolaryngol. 2020 Oct 01;:110419 Authors: Zakay D, Zakay MJ, Rosenfeld RM PMID: 33059896 [PubMed - as supplied by publisher]
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