Severe tracheobronchial harm due to lithium button battery aspiration: An in vitro study of the pathomechanism and injury pattern. Int J Pediatr Otorhinolaryngol. 2020 Oct 08;139:110431 Authors: Voelker J, Voelker C, Engert J, Schendzielorz P, Hagen R, Rak K Abstract BACKGROUND: Button battery incidents have become a rising medical issue in recent years, especially for infants. The increasing number of these cases can be explained by the expanding...
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Effects of artificial ultraviolet B radiation on the macrophyte Lemna minor: a conceptual study for toxicity pathway characterization. Planta. 2020 Oct 14;252(5):86 Authors: Xie L, Solhaug KA, Song Y, Johnsen B, Olsen JE, Tollefsen KE Abstract MAIN CONCLUSION: UVB radiation caused irradiance-dependent and target-specific responses in non-UVB acclimated Lemna minor. Conceptual toxicity pathways were developed to propose causal relationships...
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One-year costs of intensive care in pediatric patients with traumatic brain injury. J Neurosurg Pediatr. 2020 Oct 16;:1-8 Authors: Mikkonen ED, Skrifvars MB, Reinikainen M, Bendel S, Laitio R, Hoppu S, Ala-Kokko T, Karppinen A, Raj R Abstract OBJECTIVE: Traumatic brain injury (TBI) is a major cause of death and disability in the pediatric population. The authors assessed 1-year costs of intensive care in pediatric TBI patients. METHODS:...
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Plasma Golgi protein 73 levels predict prognosis of HCV-related hepatic fibrosis. Histol Histopathol. 2020 Oct 14;:18269 Authors: Liu L, Al-Dhamin Z, Yuan X, Cui L, Yang Y, Zhao W, Zhang Y, Fu N, Nan Y Abstract OBJECTIVES: To explore the correlation between plasma Golgi protein 73 (GP73) and progression of hepatitis C virus (HCV)-induced hepatic fibrosis. METHODS: A total of 232 subjects of chronic hepatitis C and 31 healthy controls...
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Analysis of The Oral Cavity: Portal to Health and Disease, a massive open online course in oral medicine. Oral Surg Oral Med Oral Pathol Oral Radiol. 2020 Sep 14;: Authors: France K, Hangorsky U, Wu CW, Sollecito TP, Stoopler ET Abstract OBJECTIVE: The aims of this study were to (1) analyze the demographic characteristics of learners participating in The Oral Cavity: Portal to Health and Disease (TOC), the first massive open online course...
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Association between childhood trauma and risk for obesity: a putative neurocognitive developmental pathway. BMC Med. 2020 Oct 15;18(1):278 Authors: Luo Q, Zhang L, Huang CC, Zheng Y, Kanen JW, Zhao Q, Yao Y, Quinlan EB, Jia T, Banaschewski T, Bokde ALW, Bromberg U, Büchel C, Flor H, Frouin V, Garavan H, Gowland P, Heinz A, Ittermann B, Martinot JL, Martinot MP, Nees F, Orfanos DP, Poustka L, Hohmann S, Fröhner JH, Smolka MN, Walter H, Whelan R, Sahakian BJ,...
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Related Articles ERS/EAACI statement on severe exacerbations in asthma in adults: facts, priorities and key research questions. Eur Respir J. 2019 09;54(3): Authors: Bourdin A, Bjermer L, Brightling C, Brusselle GG, Chanez P, Chung KF, Custovic A, Diamant Z, Diver S, Djukanovic R, Hamerlijnck D, Horváth I, Johnston SL, Kanniess F, Papadopoulos N, Papi A, Russell RJ, Ryan D, Samitas K, Tonia T, Zervas E, Gaga M Abstract Despite the use of effective...
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116 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Future Oncology These pubmed results were generated on 2020/10/19PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Reading this article will familiarize the reader with the mechanisms and causes of contact dermatitis.
Mon Oct 19, 2020 03:00
Abstract Sensorineural hearing loss is a prevalent problem that adversely impacts quality of life by compromising interpersonal communication. While hair cell damage is readily detectable with the clinical audiogram, this traditional diagnostic tool appears inadequate to detect lost afferent connections between inner hair cells and auditory nerve (AN) fibers, known as cochlear synaptopathy. The envelope-following response (EFR) is a scalp-recorded response to amplitude modulation,...
Mon Oct 19, 2020 03:00
AbstractThe occurrence of late-onset mesh infection and mesh invasion into the intestine after abdominal incisional hernia repair is extremely rare. Herein, we describe the first case of late-onset mesh infection and mesh penetrating the transverse colon and small intestine 5 years after incisional hernia repair using an expanded polytetrafluoroethylene mesh. The symptom was drainage from the reddish wound, and computed tomography scan revealed intestinal prolapse with local wall thickening. The...
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AbstractMalignant mixed Müllerian tumor of the ovary is rare aggressive tumor that is histologically defined by the presence of malignant epithelial and stromal components. We report a 37-year-old woman who consulted our facility complaining of abdominal distention and a painful palpable mass over her lower abdomen. Physical examination including computerized tomography revealed a complex cystic mass lesion on the left ovary with extensive omental involvement. Ovarian cancer was suspected and the...
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AbstractDouble-J (DJ) ureteral stent is a standard procedure in daily urological practice performed to relive ureteral obstruction or as a part of other endourological procedures. Although it is a common procedure, the widespread use of ureteral stents has corresponded to the increase in possible complication. We report a unique complication for a patient who presented with a renal subcapsular complete misplacement of DJ stent postureteroscopy for a distal ureteric stone. This challenging complication...
Mon Oct 19, 2020 03:00
AbstractObturator hernia, protrusion of abdominal content through the obturator foramen, is a rare type of abdominal wall hernia. Late patient presentation is associated with significant morbidity and mortality. We present rare case of obturator hernia causing small bowel obstruction in a 65-year-old-female patient. She presented with crampy abdominal pain, nausea and vomiting of three days duration. She was diagnosed with acute surgical abdomen and managed surgically at Arsi University College of...
Mon Oct 19, 2020 03:00
AbstractArteriovenous malformations (AVMs) are congenital vascular anomalies resulting from defects in angiogenesis. Approximately 40% of AVMs go undetected after birth and only experience the delayed clinical onset of symptoms in adulthood. AVMs are rare, representing only 1.5% of all vascular anomalies. The most common sites for the aberrant vascular nidus are the oral cavity and maxillofacial region, which represent 50% of the cases. AVMs are the most challenging and life-threatening form of vascular...
Mon Oct 19, 2020 03:00
AbstractWith a shift toward enteric drainage techniques, the complications associated with simultaneous pancreas and kidney (SPK) transplant have also changed. Gastrointestinal (GI) bleeding is one of the most common complications associated with SPK. This case report describes the treatment of a postoperative GI hemorrhage using the push endoscopy technique. A 48-year-old male underwent an uneventful SPK transplant with entero-systemic drainage and developed hematochezia. The push enteroscopy technique...
Sat Oct 17, 2020 03:00
AbstractHere we describe a case of heterotopic, supradiaphragmatic liver in a 65-year-old woman who was referred for investigation of a soft tissue gallbladder mass. Contrast-enhanced magnetic resonance imaging revealed adenomyomatosis of the gallbladder and supradiaphragmatic accessory liver tissue. This is a remarkably rare normal variant.
Sat Oct 17, 2020 03:00
High δ15N values in adult male mandrills. Abstract Mandrills are large‐bodied terrestrial forest primates living in particularly large social groups of several hundred individuals. Following these groups in the wild to assess differences in diet over time as well as among individuals is demanding. We here use isotope analyses in blood and hair obtained during repeated captures of 43 identified free‐ranging mandrills (Mandrillus sphinx) from Southern Gabon, to test how dietary variation relates...
Mon Oct 19, 2020 20:33
For recreational fishing enthusiasts, the thrill of snagging their next catch comes with discovering what's hooked on the end of the line. In many freshwater streams and rivers -- across the central and eastern parts of the U.S. -- anglers are often catching a popular freshwater game fish: the smallmouth bass. Now, scientists have discovered a new level of biodiversity within that species.
Mon Oct 19, 2020 22:59
Just like humans, microbes have equipped themselves with tools to recognize and defend themselves against viral invaders. In a continual evolutionary battle between virus and host, CRISPR-Cas act as a major driving force of strain diversity in host-virus systems.
Mon Oct 19, 2020 21:55
The basket-web spider, which is found only in Australia, has revealed it not only weaves a unique lobster pot web but that its silk has elasticity and a gluing substance, that creates a high degree of robustness.
Mon Oct 19, 2020 15:28
To develop a perceptual voice quality database for educational and research purposes.
Mon Oct 19, 2020 03:00
The field of laryngology has grown exponentially since the advent of the transnasal flexible laryngoscopy. Flexible laryngoscopy when performed skillfully using the proper technique, facilitates a good view of the hidden areas of the larynx.
Mon Oct 19, 2020 03:00
Literature review suggests that the analysis of acoustic, cepstral, and spectral parameters of voice offers excellent discrimination between the normal and pathological voices and strongly correlates with the perception of voice quality. Although the correlation between the subjective and objective voice measures can facilitate the clinician to distinguish pathological voices from normal voices, only a handful of investigations have examined the relationship between these measures in aging voices.
Mon Oct 19, 2020 03:00
Key Points Cigarette Smoke reduces hepcidin levels in the lung, plasma, and urine of mice. Cigarette smoke inhibits hepcidin production by murine AMs. AMs from smokers and individuals with COPD have higher ferroportin.
Mon Oct 19, 2020 23:00
Focused ultrasound (FUS) has recently emerged as a modulator of the tumor microenvironment, paving the way for FUS to become a safe yet formidable cancer treatment option. Several mechanisms have been proposed for the role of FUS in facilitating immune responses and overcoming drug delivery barriers. However, with the wide variety of FUS parameters used in diverse tumor types, it is challenging to pinpoint FUS specifications that may elicit the desired antitumor response. To clarify FUS bioeffects,...
Mon Oct 19, 2020 23:00
Key Points HIV infection is associated with the loss of CD163+CD206+ AM. Smoking increases surface expression of several activation markers on AM. CyTOF is a valuable tool for evaluating the phenotypic profile of BALF from smokers.
Mon Oct 19, 2020 23:00
The scale of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has thrust immunology into the public spotlight in unprecedented ways. In this article, which is part opinion piece and part review, we argue that the normal cadence by which we discuss science with our colleagues failed to properly convey likelihoods of the immune response to SARS-CoV-2 to the public and the media. As a result, biologically implausible outcomes were given equal weight as the principles set by...
Mon Oct 19, 2020 23:00
Key Points NLRP3 R259W homozygous pigs can be generated by somatic cell nuclear transfer. NLRP3 R259W homozygous pigs can survive to adulthood and give birth to offspring. Both homozygous- and heterozygous-mutated pigs show systemic spontaneous inflammation.
Mon Oct 19, 2020 23:00
Key Points Infliximab aggregates induce dendritic cell maturation and CD4 T cell activation. Aggregate-induced immune response is mediated via the FcRIIa–Syk axis.
Mon Oct 19, 2020 23:00
Key Points This study explores a pathway that promotes Th2 cell inflammation in RV exacerbation. Inhibiting factors in this pathway could potentially benefit asthmatic patients.
Mon Oct 19, 2020 23:00
Key Points B-1b cells mount superior TI-2 responses despite sharing the same BCR as B-2 cells. B-1b and B-2 cells generate a TI-2 memory pool expressing CD80, PDL2, and CD73. Ag-specific IgG and CD80 limit secondary Ab responses by memory B-1b cells.
Mon Oct 19, 2020 23:00
Key Points In brain tissue of the majority of MS patients, myelin is bound by IgG Abs. IgG immune complexes break immune tolerance of primary human microglia. Breaking of immune tolerance of microglia is dependent on FcRI and IIa.
Mon Oct 19, 2020 23:00
Key Points Clozapine binds HLA class II at therapeutic concentrations to activate CD4+ T cells. Clozapine and olanzapine interact with HLA class II in similar conformations. Greater T cell protein expression changes are induced by clozapine.
Mon Oct 19, 2020 23:00
Key Points Circulating plasmablasts are a major B cell subpopulation that expresses GZMB. GZMB+ B cells can be efficiently expanded ex vivo from total B cells. GZMB+ B cells strongly suppress both autologous and allogenic T cell proliferation.
Mon Oct 19, 2020 23:00
Key Points IFN-I–inducible TRIM21 is degraded via CMA. S. Typhimurium activates mTORC2/Akt to impair CMA resulting in TRIM21 accumulation. High levels of TRIM21 contribute to S. Typhimurium–induced macrophage death.
Mon Oct 19, 2020 23:00
Key Points CgIgIT was able to bind the hemolymph microbes and recruit CgSHP2. IgIT-SHP2 pathway inhibited MAPK activities. IgIT-SHP2 pathway protected microbes from ROS- and CgDef2-mediated elimination.
Mon Oct 19, 2020 23:00
Key Points Epigenetic changes predict cell type–specific TNF/LT locus gene expression. Distal element hHS-8 regulates TNF and LTA gene expression in activated T cells.
Mon Oct 19, 2020 23:00
Key Points Disrupting TL1A–DR3 interactions abrogates mouse lung fibrosis and airway remodeling. Airway fibroblasts and epithelial cells express DR3 and respond to TL1A. Neutralizing TL1A might be a therapy for airway remodeling in asthma, SSc, and IPF.
Mon Oct 19, 2020 23:00
Key Points LPS stimulates GFAT2 expression in macrophages via a FoxO1-dependent mechanism. LPS-induced GFAT activity promotes a general increase in protein O-GlcNAcylation. Protein O-GlcNAcylation limits excessive LPS-triggered inflammation in macrophages.
Mon Oct 19, 2020 23:00
Key Points VEGF acts directly and indirectly on stromal compartments of the neonatal thymus. VEGF mediates its pleiotropic effects via both VEGFR2 and NRP1. VEGF inhibition induces phenotypic and transcriptional neonatal thymic maturation.
Mon Oct 19, 2020 23:00
Key Points Tregs rapidly rise in the tumor microenvironment after nonablative irradiation. Transient Treg depletion increases the efficiency of nonablative irradiation. Treg depletion after three fractions of radiation induces systemic antitumor immunity.
Mon Oct 19, 2020 23:00
Key Points SARS-CoV-2–specific Ab-secreting cells expand in acute COVID-19. SARS-CoV-2–specific Ab levels correlate with neutralizing Ab titers.
Mon Oct 19, 2020 23:00
Key Points Genetic activation of CD11b reduces leukocyte recruitment in acute peritonitis. Genetic activation of CD11b decreases atherosclerosis in hyperlipidemic animals. CD11bI332G mice provide a system to study the pathways of active Mac-1 in vivo.
Mon Oct 19, 2020 23:00
Abstract Most colorectal cancer (CRC) patients are diagnosed with advanced stages and low prognosis. We aimed to identify potential diagnostic and prognostic biomarkers, as well as active small molecules of CRC. Microarray data (GSE9348, GSE35279, and GSE106582) were obtained from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) were identified by the GEO2R platform. Common DEGs were selected for Gene Ontology (GO) and Kyoto Encyclopedia of Genes and...
Mon Oct 19, 2020 03:00
The study aimed to examine the changing incidence of geriatric trauma and evaluate the predictive ability of different scoring tools for in-hospital mortality in geriatric trauma patients.
Mon Oct 19, 2020 03:00
The metallic stent is a new device for relieving the urinary tract in patients with malignant ureteral obstruction with short life expectancy and has been used frequently worldwide for its efficacy and safety....
Mon Oct 19, 2020 03:00
Stem Cells and Development, Ahead of Print.
Mon Oct 19, 2020 10:00
Stem Cells and Development, Ahead of Print.
Mon Oct 19, 2020 10:00
There were two intensive care unit (ICU) physician teams and countless nurses and respiratory therapists outside Mr. K.’s room when I arrived on the unit. The attending intensivist filled me in. "He’s maxed out on ECMO and pressors. He has a tension pneumothorax. My fellow is about to do a needle…
Wed Oct 14, 2020 03:00
Abstract Two ongoing projects at the University of Oulu, Finland, are studying burials situated below the floorboards of Finnish churches. The projects examine mortality and materiality in Finland using an exceptionally well-preserved assemblage of mummified human remains. Multidisciplinary research methods, including CT scanning, μCT scanning, sampling for DNA and isotope analysis, and insect and plant samples, are providing multifaceted information concerning past societies....
Mon Oct 19, 2020 03:00
ObjectivesWe compared COVID-19 risk management, fear of infection and fear of transmission of infection among frontline employees working within eldercare, hospital/rehabilitation, psychiatry, childcare and ambulance service and explored if group differences in fear of infection and transmission could be explained by differences in risk management. We also investigated the association of risk management with fear of infection and fear of transmission of infection among eldercare personnel.MethodsWe...
Mon Oct 19, 2020 19:00
Condition: Nasopharyngeal CarcinomaIntervention: Procedure: Trans-oral magnifying endoscopy with NBISponsor: Chinese University of Hong KongNot yet recruiting
Mon Oct 19, 2020 19:00
Condition: Advanced Solid TumorIntervention: Biological: CDK-002Sponsor: Codiak BioSciencesRecruiting
Mon Oct 19, 2020 19:00
Condition: Scoliosis PatientsIntervention: Diagnostic Test: UltrasonographySponsor: Istanbul UniversityRecruiting
Mon Oct 19, 2020 19:00
Condition: Squamous Cell Carcinoma of the Head and NeckInterventions: Drug: Monalizumab; Drug: CetuximabSponsors: AstraZeneca; Innate PharmaRecruiting
Fri Oct 16, 2020 19:00
Condition: Thyroid Gland CarcinomaInterventions: Drug: Hyperpolarized Carbon C 13 Pyruvate; Procedure: Magnetic Resonance ImagingSponsors: M.D. Anderson Cancer Center; National Cancer Institute (NCI)Recruiting
Thu Oct 15, 2020 19:00
Conditions: Recurrent Head and Neck Squamous Cell Carcinoma; Recurrent Hypopharyngeal Squamous Cell Carcinoma; Recurrent Laryngeal Squamous Cell Carcinoma; Recurrent Oral Cavity Squamous Cell Carcinoma; Recurrent Oropharyngeal Squamous Cell Carcinoma; Resectable Oropharyngeal Squamous Cell CarcinomaIntervention: Biological: Efineptakin alfaSponsors: Hyunseok Kang, MD; NeoImmuneTechNot yet recruiting
Thu Oct 15, 2020 19:00
Caseous lymphadenitis (CL) is a chronic infectious disease that affects sheep and goats. Many serological tests have been developed to detect the disease; one of the most widely used is the enzyme-linked immun...
Mon Oct 19, 2020 03:00
In vitro eradication of the C. albicans and S. mutans mixed biofilms by eugenol alone and in combination with the antimicrobial drugs. Previously characterized strains of C. albicans (CAJ-01 and CAJ-12) and S. mu...
Mon Oct 19, 2020 03:00
New Findings What is the central question of this study? Does creatine supplementation augment the total torque impulse accumulated above end‐test torque (IET) during severe‐intensity knee‐extensor exercise by attenuating the rate of decrease in peak potentiated twitch torque (PT)? What is the main finding and its importance? Creatine augmented the IET and attenuated the rate of decrease in both voluntary activation and PT during severe‐intensity exercise. The IET was related...
Sun Oct 18, 2020 16:33
Deep brain stimulation (DBS) is a complex surgical procedure that requires detailed anatomical knowledge. In many fields of neurosurgery navigation systems are used to display anatomical structures during an operation to aid performing these surgeries. In frame-based DBS, the advantage of visualization has not yet been evaluated during the procedure itself. In this study, we added live visualization to a frame-based DBS system, using a standard navigation system and investigated its accuracy and...
Mon Oct 19, 2020 16:33
Proteolytic balance is crucial for the maintenance of tissue homeostasis. In cancer, dysregulated proteolysis is involved in unregulated tissue remodeling and inflammation, leading to the promotion of tumor growth, local invasion, and metastasis. Metalloproteinases, which were first identified as collagen cleaving enzymes, have been shown to extensively degrade extracellular matrix proteins or selectively release cell surface‐bound cytokines, growth factors, or their receptors, thereby impacting...
Mon Oct 19, 2020 17:19
Publication date: Available online 19 October 2020Source: World NeurosurgeryAuthor(s): François Dantas, Antônio Carlos Vieira Caires, Gustavo Agra Cariri, Fernando Luiz Rolemberg Dantas
Mon Oct 19, 2020 18:45
Publication date: Available online 19 October 2020Source: World NeurosurgeryAuthor(s): Aladine A. Elsamadicy, Isaac G. Freedman, Andrew B. Koo, Wyatt B. David, John Havlik, Adam J. Kundishora, Christopher S. Hong, Daniel M. Sciubba, Kristopher T. Kahle, Michael DiLuna
Mon Oct 19, 2020 18:45
Publication date: Available online 19 October 2020Source: World NeurosurgeryAuthor(s): Renaud Lafage, Bryan Ang, Basel Sheikh Alshabab, Jonathan Elysee, Francis Lovecchio, Karen Weissman, Han Jo Kim, Frank Schwab, Virginie Lafage
Mon Oct 19, 2020 18:45
Publication date: Available online 19 October 2020Source: World NeurosurgeryAuthor(s): Tomoki Sasagasako, Junya Hanakita, Toshiyuki Takahashi, Manabu Minami, Ryo Kanematsu, Yosuke Tomita
Mon Oct 19, 2020 18:45
Publication date: Available online 19 October 2020Source: World NeurosurgeryAuthor(s): Juan Silvestre G. Pascual, Abdelsimar T. Omar, Mairre James S. Gaddi, Rafa Jireh O. Iglesias, Katrina Hannah D. Ignacio, Geraldine Raphaela B. Jose, Mitchel S. Berger, Gerardo D. Legaspi
Mon Oct 19, 2020 18:45
Abstract Background The spread of digital technology in dentistry poses new challenges and sets new goals for dentists. The aim of the present in vivo study was to determine the learning curve of intraoral scanning described by (1) scanning time and (2) image number (count of images created by intraoral scanner during the scanning process). Methods ...
Mon Oct 19, 2020 03:00
Abstract Background To find out whether misuse of dental hygiene, in terms of certain dental habits, may facilitate the spread of COVID-19 among cohabiting individuals. Methods 302 COVID-19 infected (PCR +) subjects cohabiting with someone else at home were selected for an observational cross-sectional study. An anonymous online questionnaire...
Mon Oct 19, 2020 03:00
Publication date: November 2020Source: European Journal of Cancer, Volume 140Author(s): Laurèl Rauschenbach, Anja Wieland, Roman Reinartz, Sied Kebir, Andreas Till, Marvin Darkwah Oppong, Celia Dobersalske, Vivien Ullrich, Ashar Ahmad, Ramazan Jabbarli, Daniela Pierscianek, Holger Fröhlich, Matthias Simon, Oliver Brüstle, Ulrich Sure, Martin Glas, Björn Scheffler
Mon Oct 19, 2020 17:56
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. MiR-124-3p has been identified as a novel tumor suppressor and a potential therapeutic target in hepatocellular carcinoma (HCC) through regulating its target genes. However, the upstream regulatory mechanisms of mir-124-3p in HCC has not been fully understood. The transcription factor liver X receptor (LXR) plays a critical role in suppressing the proliferation of HCC cells, but it is unclear whether LXR is involved...
Mon Oct 19, 2020 13:25
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. The functions of Long noncoding RNA (lncRNA) HOXB-AS1 have been investigated in glioblastoma and multiple myeloma. However, the role of lncRNA HOXB-AS1 in endometrial carcinoma (EC) remains largely unknown. This study investigated the underlying mechanisms of the lncRNA HOXB-AS1 on the progression of EC. In this study, We found that HOXB-AS1 expression was significantly upregulated in EC tissue samples and was...
Mon Oct 19, 2020 13:23
Oncogenic Long Noncoding RNA DARS-AS1 in Childhood Acute Myeloid Leukemia by Binding to microRNA-425
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Objective:Acute myeloid leukemia (AML) represents a hematological cancer. The aim of the investigation was to probe the regulatory relevance of long non-coding RNA (lncRNA) aspartyl-tRNA synthetase anti-sense 1 (DARS-AS1)/microRNA-425 (miR-425)/transforming growth factor-beta 1 (TGFB1) to the development of AML.Methods:The DARS-AS1 expression in bone marrow tissues was first analyzed in healthy subjects and AML...
Mon Oct 19, 2020 13:21
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. This study aimed to compare the performance of MilliSect dissection and manual dissection. Twenty-five formalin-fixed paraffin-embedded (FFPE) breast cancer tissue blocks were selected for comparison. Specific areas of interest (AOIs) in invasive carcinoma on tissue sections were transferred to dissection slides by manual macrodissection or the MilliSect instrument. The comparison criteria were 1) the time required...
Mon Oct 19, 2020 13:20
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. In this study we aimed to identify a set of prognostic factors for angioimmunoblastic T-cell lymphoma (AITL) and establish a novel prognostic model. The clinical data of 64 AITL patients enrolled to the Fourth Hospital of Hebei Medical University (from 2012 Jan to 2017 May) were retrospectively analyzed. The estimated 5-year overall survival and progression-free survival of this cohort of patients were 45.8% and...
Mon Oct 19, 2020 13:18
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Background and Objectives:Although cholangiolocellular carcinoma is considered a combined hepatocellular and cholangiocarcinoma, we feel that this classification is not appropriate. Therefore, we compared the diagnostic imaging findings, surgical prognosis, and pathological features of cholangiolocellular carcinoma with those of other combined hepatocellular and cholangiocarcinoma subtypes, hepatocellular carcinoma,...
Mon Oct 19, 2020 13:16
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Objective:Concurrent chemoradiation (cCHRT) has been confirmed as the standard treatment for local advanced non-small-cell lung cancer (NSCLC). This study is to assess the appropriate timing of radiotherapy and cycles of induction chemotherapy for those patients.Methods:227 inoperable stage III NSCLC patients were selected, we analyzed the potential prognostic factors and the influence of induction chemotherapy...
Mon Oct 19, 2020 13:15
Flowchart of the study. Abstract Purpose The anatomy of the articular surfaces has historically identified as major responsible for acromioclavicular joint osteoarthritis (ACJO). On the other side, the almost 100% prevalence of ACJO in subjects over 50 years old seems to suggest a multifactorial etiology. We compared ACJO between asymptomatic elderly monozygotic (MZ) and dizygotic (DZ) twins to investigate the influence of genetics and environmental factors. Materials and Methods Thirty...
Mon Oct 19, 2020 17:32
Publication date: Available online 18 October 2020Source: The Journal of Prosthetic DentistryAuthor(s): Letícia Del Rio Silva, Daniele Valente Velôso, Thaís Barbin, Guilherme Almeida Borges, Anna Gabriella Camacho Presotto, Marcelo Ferraz Mesquita
Mon Oct 19, 2020 16:50
Introduction: Perception and memorizing of melody and rhythm start about the third trimester of gestation. Infants have astonishing musical predispositions, and melody contour is most salient for them. Objective: To longitudinally analyse melody contour of spontaneous crying of healthy infants and to identify melodic intervals. The aim was 3-fold: (1) to answer the question whether spontaneous crying of healthy infants regularly exhibits melodic intervals across the observation period, (2) to investigate...
Mon Oct 19, 2020 16:06
Publication date: December 2020Source: Biomedicine & Pharmacotherapy, Volume 132Author(s): Atteneri López-Arencibia, Carlos J. Bethencourt-Estrella, Mónica B. Freijo, María Reyes-Batlle, Ines Sifaoui, Desirée San Nicolás-Hernández, Grant McNaughton-Smith, Jacob Lorenzo-Morales, Teresa Abad-Grillo, José E. Piñero
Mon Oct 19, 2020 16:34
Abstract Introduction Perineal pressure associated with bicycle riding is the cause of several genitourinary pathologies, most notably Alcock’s syndrome and subsequent perineal numbness. The possible link between cycling-induced perineal numbness and erectile dysfunction makes the development of strategies for perineal protection in bicycle users critical. Objective ...
Mon Oct 19, 2020 03:00
Publication date: December 2020Source: Brain and Language, Volume 211Author(s): McCall E. Sarrett, Bob McMurray, Efthymia C. Kapnoula
Mon Oct 19, 2020 16:20
Propofol anesthesia rapidly causes loss of consciousness, while the neural mechanism underlying this phenomenon is still unclear. Glutamatergic neurons in the basal forebrain play an important role in initiation and maintenance of wakefulness. Here, we selectively recorded the activity of glutamatergic neurons in vGlut-2-Cre mice. Propofol induced outward currents in a concentration-dependent manner. Bath application of propofol generated membrane hyperpolarization and suppressed the firing rates...
Fri Oct 16, 2020 03:00
Nischarin (NISCH) is a key protein functioning as a molecular scaffold and thereby hosting interactions with several protein partners. Here, we aimed to investigate whether NISCH downregulation could protect rat pheochromocytoma (PC12) cells against oxidative stress-induced injury using a model of cell injury induced by hydrogen peroxide (H2O2). Cell viability was evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Cell apoptosis rate was evaluated using flow cytometry....
Fri Oct 16, 2020 03:00
It has been shown that morphine addiction impairs cognitive brain functions. However, there is no document to consider the effect of morphine dependency and its withdrawal on cost-benefit decision making and its molecular pathways. The present study aimed to evaluate the influences of morphine dependency and its withdrawal on delay-based decision making and the BDNF, p-GSK3β, and p-CREB levels during the decision making in the hippocampus. Different groups of rats were trained in a T-maze with the...
Fri Oct 16, 2020 03:00
Previous studies have identified that functional constipation (FCon) is associated with functional and structural alterations in the primary brain regions involved in emotional arousal processing, sensory processing, somatic/motor‐control and self‐referential processing. However, whether FCon is associated with abnormal structural connectivity (SC) among these brain regions remains unclear. In the current study, we selected the brain regions with functional and structural abnormalities as seed...
Mon Oct 19, 2020 14:02
Abstract Background and purpose To compare dosimetrically the radiation exposure to heart, left ventricle (LV), and left anterior descending artery (LAD) between whole-breast radiotherapy (WBRT) with Active Breathing Coordinator (ABC; ABC-WBRT) and interstitial multicatheter high-dose-rate (HDR) brachytherapy as accelerated partial breast irradiation (ABPI; imHDR-APBI) for left-sided breast cancer (BCA) after breast-conserving surgery...
Mon Oct 19, 2020 03:00
Publication date: Available online 18 October 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Christopher C. Donnell, Richard L. Walton, Marco Carrozzo
Mon Oct 19, 2020 15:41
Publication date: Available online 18 October 2020Source: Brain Research BulletinAuthor(s): Penghui Zhao, Li Meng, Mengxiao Dou, Jiawen Mao, Ge Zhang, Min Zheng, Xi Yin, Zifei Tao, Miao Gong, Li Song, Kaoqi Lian, Omar Israel Velez de-la-Paz, Qingjun Guo, Haishui Shi
Mon Oct 19, 2020 15:40
Publication date: Available online 18 October 2020Source: Brain Research BulletinAuthor(s): István Gyertyán, Ferenc Kassai, Kata Kozma, Tamás Kitka, Aliz Judit Ernyey
Mon Oct 19, 2020 15:40
Publication date: Available online 18 October 2020Source: International Journal of PsychophysiologyAuthor(s): Markus T. Jansen, Sascha Tamm, Thomas Merten, Anett Tamm, Markus J. Hofmann
Mon Oct 19, 2020 15:25
Molecular magnetic resonance (MR) imaging utilizes molecular probes to provide added biochemical or cellular information to what can already be achieved with anatomical and functional MR imaging. This review provides an overview of molecular MR and focuses specifically on molecular MR contrast agents that provide contrast by shortening the T1 time. We describe the requirements for a successful molecular MR contrast agent and the challenges for clinical translation. The review highlights work from...
Fri Oct 16, 2020 03:00
Objectives The aim of this study was to quantify the spatial temperature rises that occur during 1.5- and 3.0-T magnetic resonance imaging (MRI) of different types of hip arthroplasty implants using different metal artifact reduction techniques. Materials and Methods Using a prospective in vitro study design, we evaluated the spatial temperature rises of 4 different total hip arthroplasty constructs using clinical metal artifact reduction techniques including high-bandwidth turbo spin...
Fri Oct 16, 2020 03:00
Publication date: Available online 18 October 2020Source: Acta Otorrinolaringológica EspañolaAuthor(s): Margarita Mesa-Marrero, Begoña de Frias-Berzosa, Elena Hernández-Montero, Andrea Alvarez-Roger, Paula Cruz-Toro
Mon Oct 19, 2020 15:16
Abstract Inactivating mutations of SERPINB6 in humans result in progressive hearing loss starting in early adulthood (DFNB91). We have previously shown that C57BL/6J mice lacking the orthologous gene, Serpinb6a, exhibit progressive hearing loss, which is associated with progressive loss of distinct cell types in the organ of Corti beginning with outer hair cells. However, deafness in these animals occurs much earlier than expected, possibly because C57BL/6J mice also carry an age‐related hearing...
Mon Oct 19, 2020 14:38
Abstract Freezing of gait (FoG) is one of the main reasons for movement initiation disorders and abnormal coupling of posture and gait in Parkinson’s disease (PD). Patients with FoG have poor postural control when compared to patients without FoG. However, the nature of the interrelationship between FoG and domains of postural control remains unknown. The aim of this study was to estimate the association between different domains of postural control and severity of FoG in patients with moderate‐to‐severe...
Mon Oct 19, 2020 14:38
Meningiomas are a central nervous system tumor primarily afflicting adults, with
Fri Oct 16, 2020 03:00
Currently, there is no consensus on the optimal tumor response score (TRS) system to assess regression in pancreatic cancers resected after neoadjuvant therapy. We developed a novel TRS (Royal North Shore [RNS] system) based on estimating the percentage of tumor bed occupied by viable cancer and categorized into 3 tiers: grade 1 (≤10%), grade 2 (11% to 75%), and grade 3 (>75%). We assessed 147 resected carcinomas with this and other TRS systems (College of American Pathologists [CAP], MD Anderson...
Fri Oct 16, 2020 03:00
Publication date: Available online 19 October 2020Source: Behavioural Brain ResearchAuthor(s): T. Lorivel, J. Cendelin, P. Hilber
Mon Oct 19, 2020 13:56
Abstract Parasites can select for sexual reproduction in host populations, preventing replacement by faster growing asexual genotypes. This is usually attributed to so‐called “Red Queen Dynamics” (RQD), where antagonistic coevolution causes fluctuating selection in allele frequencies, which provides sex with an advantage over asex. However, parasitism may also maintain sex in the absence of RQD when sexual populations are more genetically diverse – and hence more resistant, on average – than clonal...
Sun Oct 18, 2020 20:33
Temperature experienced during early development often affects the expression of adult traits; however, few studies have looked at whether developmental environments affect male sperm traits. We reared male mosquito fish (Gambusia holbrooki) in warm and cool temperatures and then measured their sperm number and sperm velocity (in both warm and cool temperatures) as adults. We found no effect of rearing temperature on sperm number. For sperm velocity, we found that sperm swam faster at warmer testing...
Sun Oct 18, 2020 16:59
Publication date: Available online 18 October 2020Source: Allergology InternationalAuthor(s): Takao Mochimaru, Shotaro Chubachi, Hidehiro Irie, Kaori Sakurai, Shinichi Okuzumi, Keeya Sunata, Katsunori Masaki, Jun Miyata, Hidetoshi Nakamura, Koichiro Asano, Koichi Fukunaga
Mon Oct 19, 2020 13:38
Publication date: Available online 18 October 2020Source: Pathology - Research and PracticeAuthor(s): Caroline Scheifele, Qi Zhu, Atanas Ignatov, Thomas Kalinski, Norbert Nass
Mon Oct 19, 2020 13:35
No abstract available
Fri Oct 16, 2020 03:00
Introduction: Brain injuries can cause systemic immunosuppression, which in turn can lead to infections that adversely affect the injured brain and worsen clinical outcomes. This study aimed to investigate whether systemic infection, such as ventilator-associated pneumonia (VAP), induce intracranial inflammation in patients with subarachnoid hemorrhage (SAH). Methods: This prospective, observational study included 16 adults with SAH treated in the neuro-intensive care unit. Three paired...
Fri Oct 16, 2020 03:00
Background: The COVID-19 pandemic is an international crisis placing tremendous strain on medical systems around the world. Like other specialties, neuroanesthesiology has been adversely affected and training programs have had to quickly adapt to the constantly changing environment. Methods: An email-based survey was used to evaluate the effects of the pandemic on clinical workflow, clinical training, education, and trainee well-being. The impact of the International Council on Perioperative...
Fri Oct 16, 2020 03:00
No abstract available
Fri Oct 16, 2020 03:00
ABSTRACT ObjectiveOur knowledge of symptom burden and functioning among adolescent and young adult (AYA; diagnosed ages 15‐39) cancer survivors has been hindered by variability in health‐related quality of life (HRQOL) measurement associated with developmental and disease heterogeneity among AYAs. We aimed to examine the variability in domain‐specific aspects of HRQOL as a function of cancer type and developmental stage to clarify commonalities and differences using the NIH Patient‐Reported Outcome...
Mon Oct 19, 2020 13:04
Abstract Purpose of Review The glymphatic system is a relatively new concept that has been associated with regulation of cerebrospinal fluid (CSF), as well as brain waste clearance. Novel techniques to study glymphatic dysfunction have in turn prompted a reassessment of brain physiology and underlying elements of neurological disease. This review incorporates a contemporary imaging perspective focused on understanding the regulation...
Mon Oct 19, 2020 03:00
Abstract Chronic myeloid leukemia (CML) is driven by the BCR‐ABL oncoprotein, a constitutively active protein tyrosine kinase. Although tyrosine kinase inhibitors (TKIs) have greatly improved the prognosis of CML patients, the emergence of TKI resistance is an important clinical problem, which deserves additional treatment options based on unique biological properties to CML cells. In this study, we show that metabolic homeostasis is critical for survival of CML cells especially when the disease...
Sun Oct 18, 2020 22:50
Abstract The understanding of microRNAs (miRNAs) regulatory system has become indispensable for physiological/oncological research. Tissue‐ and organ‐specificities are key features of miRNAs that should be accounted for in cancer research. Further, the cancer‐specific energy metabolism, referred to as the Warburg effect, has been positioned as a key cancer feature. An enhancement of the glycolysis pathway in cancer cells is what primarily characterizes the Warburg effect. Pyruvate kinase M1/2 (PKM1/2)...
Sun Oct 18, 2020 22:46
Abstract Recent studies of the cancer genome have identified numerous patients harboring multiple mutations (MMs) within individual oncogenes. These MMs (de novo MMs) in cis synergistically activate the mutated oncogene and promote tumorigenesis, indicating a positive epistatic interaction between mutations. The relatively frequent de novo MMs suggest that intramolecular positive epistasis is widespread in oncogenes. Studies also suggest that negative and higher‐order epistasis affects de novo MMs....
Sun Oct 18, 2020 20:18
Abstract The turnover of intestinal epithelial cells (IECs) is relatively rapid (3 to 5 days in mouse and human), and this short existence and other aspects of the homeostasis of IECs are tightly regulated by various signaling pathways including Wnt–β‐catenin signaling. Dysregulation of IEC homeostasis likely contributes to the development of intestinal inflammation and intestinal cancer. The roles of receptor protein tyrosine kinases and their downstream signaling molecules such as Src family kinases,...
Sun Oct 18, 2020 20:17
Publication date: Available online 18 October 2020Source: TalantaAuthor(s): Yaping Xia, Yang Sun, Huamin Li, Shuo Chen, Tiying Zhu, Guangcan Wang, Baoyuan Man, Jie Pan, Cheng Yang
Mon Oct 19, 2020 12:13
Abstract Attendance at early recall and colposcopy is crucial to attaining the benefits of primary high‐risk human papillomavirus (HR‐HPV)‐based screening. Within the English HPV pilot, we analysed deprivation‐ and age‐related patterns of attendance at colposcopy and 12‐ and 24‐month early recall of HR‐HPV positive women screened in 2013‐2015 (N=36,466). We fitted logistic regression models for adjusted odds ratios (OR). Despite high overall attendance, area deprivation had a small but significant...
Sun Oct 18, 2020 18:14
Abstract MARC‐2, a prospective, multicenter phase IV trial, aimed to investigate clinical outcomes in patients with metastatic renal cell carcinoma (mRCC) treated with everolimus after failure of one initial vascular endothelial growth factor receptor tyrosine kinase inhibitor (VEGFR‐TKI) therapy and to identify subgroups benefiting most, based on clinical characteristics and biomarkers. Patients with clear cell mRCC failing one initial VEGFR‐TKI received everolimus until progression or unacceptable...
Sun Oct 18, 2020 18:12
Abstract Early diagnosis and treatment of retinoblastoma (Rb), the most common intraocular malignancy, can save both the child’s life and vision. However, access to services and hence chances for survival and preserving the eye and its vision vary widely across the globe. Some families have to, or make a choice to, leave their home country to seek planned medical treatment abroad. We aimed to investigate how frequently this cross border travel occurs and the factors associated with it. A total...
Sun Oct 18, 2020 18:09
Background: Several materials are available for cranioplasty reconstruction and consensus regarding the ideal material is lacking. The goal of this study is to present surgical and patient-reported outcomes with PEEK versus Titanium alloplastic cranioplasty. Methods: A retrospective review of all patients who underwent alloplastic cranioplasty with PEEK or Titanium from 2010 to 2017 was conducted. Patient demographics and complications were abstracted and analyzed. Information regarding...
Thu Oct 15, 2020 03:00
No abstract available
Thu Oct 15, 2020 03:00
Petrous apex effusions are rare disorders and usually occur in the petrous apex (PA) having well-aerated cells and it may present with several symptoms or can be diagnosed incidentally on imaging methods obtained for another reason. If there are persistent symptoms despite the conservative treatment in symptomatic patients, a surgical attempt can be considered. In patients with favorable hearing levels and with the well-pneumatized petrous bone, PA cells may be effectively drained through subcochlear...
Thu Oct 15, 2020 03:00
Background: Pfeiffer syndrome is associated with a genetic mutation of the FGFR2 (or more rarely, FGFR1) gene, and features the combination of craniosynostosis, midface hypoplasia, broad thumbs and broad great toes. Previous research has identified a wide spectrum of clinical phenotypes in patients with Pfeiffer syndrome. This study aimed to investigate the multifactorial considerations for speech, language, hearing and feeding development in patients with severe genetically-confirmed Pfeiffer...
Thu Oct 15, 2020 03:00
Hemifacial microsomia (HFM) is also known as malformation of the first and second branchial arches (BAs), oculoauriculovertebral dysplasia syndrome, and Goldenhar syndrome. Possibilities resulting from CAD/CAM may be a valuable tool to existing procedures to treat these abnormalities. The aim of this study was to report a case where the planning and implementation of an intraorally inserted 2-part patient-specific mandible implant was used for the treatment of HFM esthetic remained problem after...
Thu Oct 15, 2020 03:00
Objective: Epidural fluid collection (EFC) is one of the postoperative complications of cranioplasty and is easily ignored. Not only the predictive factors of EFC formation are unknown, the pathologic mechanisms are also unknown. We determined to analyze the predictive factors and the mechanism of EFC formation. Methods: A total of 340 patients underwent cranioplasty were retrospectively analyzed in this study. A series of factors were compared in the EFC and none-EFC groups and farther...
Thu Oct 15, 2020 03:00
Numerous methods for surgical correction of sagittal synostosis have been described in the literature, yielding similar outcomes. At the authors’ institution, surgical approaches to correct this condition have evolved over the past few decades, including Π, H-type craniectomies (Renier), endoscopic suturectomy, and our current technique, the FLAG procedure. Our aim is to review the evolution of these surgical techniques at our institution and compare patient outcomes. A retrospective review was performed...
Thu Oct 15, 2020 03:00
The purpose of this retrospective study was to compare outcomes of cleft palate repair in patients with non-syndromic Pierre Robin sequence (NS-PRS) versus those with non-syndromic isolated cleft palate (NS-ICP). Pierre Robin sequence (PRS) was defined as a diagnosis of the triad of microretrognathia, glossoptosis, and cleft palate, and the severity of PRS was assessed based on the presence of respiratory and feeding problems. All patients underwent palatoplasty between January 2000 and December...
Thu Oct 15, 2020 03:00
Introduction: Powered intracapsular tonsillectomy (PIT) is a technique that protects the tonsillar capsule by using a microdebrider, resulting in faster wound-healing and reduced suffering. Many studies have found PIT to be effective, particularly in pediatric patients with obstructive sleep apnea (OSA). However, previous studies have not included patients with a history of recurrent tonsillitis. Objective: The aim of this study was to determine the efficacy of PIT in pediatric patients even with...
Mon Oct 19, 2020 11:24
Aspiration prevention (AP) surgery may improve the quality of life (QOL) of patients with severe dysphagia. However, not all patients can endure this type of surgery under general anesthesia because of their poor status. Herein, we describe the cases of 2 patients with head and neck cancer (HNC) who underwent AP surgery for palliative care. Although both patients had tracheostomy due to severe dysphagia and respiratory impairment and frequently needed suction, they were successfully managed with...
Mon Oct 19, 2020 10:14
Objectives: Because unresolved debris in the ear canal or middle ear of newborns may produce high false positive rates on hearing screening tests, it has been suggested that an outer/middle ear measure can be included at the time of hearing screening. A potential measure is power absorbance (absorbance), which indicates the proportion of power in a broadband acoustic stimulus that is absorbed through the outer/middle ear. Although absorbance is sensitive to outer/middle dysfunction at birth, there...
Fri Oct 16, 2020 03:00
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