Periodic Acid-Schiff Stain in Circumscribed Hypokeratosis.

No abstract available

http://ift.tt/2d4sCsF

Metastatic Malignant Pilomatrixoma in an 8-Year-Old Girl Misdiagnosed as a Recurrent Pilomatrixoma.

Malignant pilomatrixoma or pilomatrix carcinoma is a rare, locally aggressive malignant neoplasm, derived from the hair follicle with a high propensity for local recurrence. Only a few cases of metastatic pilomatrixoma have been described in the literature. Till date, only 17 cases have been reported in the English-language medical literature, most commonly occurring associated with local recurrence in adults. We report the first case in children of a metastatic malignant pilomatrixoma in an 8-year-old girl presenting with a recurrent pilomatrix carcinoma of the forehead with metastases in cervical and parotid lymph nodes. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.

http://ift.tt/2dpIbX2

The Clinical Study of the Poorly Differentiated Head and Neck Squamous Cell Carcinoma

Condition:   Carcinoma, Squamous Cell
Intervention:  
Sponsor:   Beijing Tongren Hospital
Not yet recruiting - verified September 2016

http://ift.tt/2d7CI7R

Study of Extensive Clinical Target Volumes in Postoperative Radiotherapy Concurrent With Chemotherapy for Esophageal Squamous Cell Carcinoma

Condition:   Esophageal Squamous Cell Carcinoma
Interventions:   Drug: Paclitaxel;   Drug: Carboplatin;   Radiation: Radiotherapy
Sponsor:   Fudan University
Not yet recruiting - verified September 2016

http://ift.tt/2dAzjRJ

A Trial of Neoadjuvant Chemotherapy for Stage II, III Esophageal Squamous Cell Carcinoma

Condition:   Stage II and III Esophageal Squamous Cell Carcinoma
Interventions:   Drug: DCX;   Procedure: surgery
Sponsor:   Sun Yat-sen University
Not yet recruiting - verified September 2016

http://ift.tt/2d7DZMg

The Study to Evaluate JS001 in Patients With Advanced GC, ESCC, NPC, HNSCC

Conditions:   Gastric Adenocarcinoma;   Esophageal Squamous Cell Carcinoma;   Nasopharyngeal Carcinoma;   Head and Neck Squamous Cell Carcinoma
Interventions:   Biological: 3 mg/kg humanized anti-PD-1 mAb;   Biological: 10 mg/kg humanized anti-PD-1 mAb
Sponsor:   Shanghai Junshi Bioscience Co.,Ltd.
Not yet recruiting - verified September 2016

http://ift.tt/2dAA0KM

EpCAM CAR-T for Treatment of Nasopharyngeal Carcinoma and Breast Cancer

Conditions:   Malignant Neoplasm of Nasopharynx TNM Staging Distant Metastasis (M);   Breast Cancer Recurrent
Intervention:   Biological: CAR-T cells recognizing EpCAM
Sponsor:   Sichuan University
Recruiting - verified September 2016

http://ift.tt/2dhXnos

Hyperfocusing as a dimension of adult attention deficit hyperactivity disorder

Publication date: December 2016
Source:Research in Developmental Disabilities, Volume 59
Author(s): Erguvan Tugba Ozel-Kizil, Ahmet Kokurcan, Umut Mert Aksoy, Bilgen Bicer Kanat, Direnc Sakarya, Gulbahar Bastug, Burcin Colak, Umut Altunoz, Sevinc Kirici, Hatice Demirbas, Bedriye Oncu
Patients with Attention Deficit Hyperactivity Disorder (ADHD) suffer not only from inability to focus but also from inability to shift attention for events that trigger their interests. This phenomenon is called "hyperfocusing". Previous literature about hyperfocusing is scarce and relies mainly on case reports. The study aimed to investigate and compare the severity of hyperfocusing in adult ADHD with and without psycho-stimulant use. ADHD (DSM-IV-TR) patients either psycho-stimulant naive (n=53) or on psycho-stimulants (n=79) from two ADHD clinics were recruited. The control group (n=65) consisted of healthy university students. A socio-demographic form, the Beck Depression Inventory, the Wender-Utah Rating Scale, the Adult ADHD Self- Report Scale and the Hyperfocusing Scale were applied to the participants. There was no difference between total Hyperfocusing Scale and Adult ADHD Self- Report Scale scores of two patient groups, but both have higher scores than controls (p<0.001). Hyperfocusing is higher in adult ADHD and there was no difference between stimulant-naive patients or patients on stimulants. Hyperfocusing can be defined as a separate dimension of adult ADHD.



http://ift.tt/2cTjz8q

Scholar : These new articles for Australian Journal of Maritime & Ocean Affairs are available online

The online platform for Taylor & Francis Online content New for Australian Journal of Maritime & Ocean Affairs and online now on Taylor & Francis Online: Original Articles The India–Japan strategic partnership: evolving synergy in the Indo-Pacific Ramanand Garge Pages: 1-10 | DOI: 10.1080/18366503.2016.1235362 Time and tide wait for no man (or woman). Explore the multidisciplinary TIME Collection now. This message is personalised to your status as a society member. Please do not forward this email. To recommend content, please use the social sharing tools on the website. To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Airway Management of a Patient with an Acute Floor of the Mouth Hematoma after Dental Implant Surgery in the Lower Jaw

Publication date: Available online 27 September 2016
Source:The Journal of Emergency Medicine
Author(s): Maarten J.J.B. Vehmeijer, Naomi Verstoep, Jan E.H. Wolff, Engelbert A.J.M. Schulten, Bas van den Berg
BackgroundOver the last decades, dental implants have become increasingly popular in the prosthetic rehabilitation of patients. This has subsequently led to an increase of perioperative complications. Obstruction of the airway as a result of a floor of mouth hematoma after dental implant surgery is a rare but life-threatening complication.Case ReportA 62-year-old man presented to the emergency department with a compromised airway caused by a hematoma in the floor of the mouth that occurred during dental implant surgery in the edentulous anterior mandible. Computed tomography angiography images revealed an elevation of the floor of mouth with subsequent occlusion of the airway. In addition, a perforation of the lingual mandibular cortical plate was observed that was caused by two malpositioned dental implants. Awake fiberoptic intubation was immediately performed, the two malpositioned dental implants were subsequently removed, and the patient was extubated after 3 days.Why Should an Emergency Physician Be Aware of This?Perforation of the lingual mandibular cortical plate during dental implant surgery can lead to life-threatening bleeding in the floor of the mouth. This condition can be successfully treated by awake fiberoptic intubation and, if necessary, the malpositioned dental implants can be subsequently removed.



http://ift.tt/2cAFULV

Effect of a Multi-Diagnosis Observation Unit on Emergency Department Length of Stay and Inpatient Admission Rate at Two Canadian Hospitals

Publication date: Available online 27 September 2016
Source:The Journal of Emergency Medicine
Author(s): Amy H.Y. Cheng, Neil G. Barclay, Riyad B. Abu-Laban
BackgroundObservation units (OUs) have been shown to reduce emergency department (ED) lengths of stay (LOS) and admissions. Most published studies have been on OUs managing single complaints.ObjectiveOur aim was to determine whether an OU reduces ED LOS and hospital admission rates for adults with a variety of presenting complaints.MethodsWe comparatively evaluated two hospitals in British Columbia, Canada (hereafter ED A and ED B) using a pre–post design. Data were extracted from administrative databases. The post-OU cohort included all adults presenting 6 months after OU implementation. The pre-OU cohort included all adults presenting in the same 6-month period 1 year before OU implementation.ResultsThere were 109,625 patient visits during the study period. Of the 56,832 visits during the post-OU period (27,512 to ED A and 29,318 to ED B), 1.9% were managed in the OU in ED A and 1.4% in ED B. Implementation was associated with an increase in the median ED LOS at ED A (179.0 min pre vs. 192.0 min post [+13.0 min]; p < 0.001; mean difference −12.5 min, 95% confidence interval [CI] −15.2 to −9.9 min), but no change at ED B (182.0 min pre vs. 182.0 min post; p = 0.55; mean difference +2.0 min, 95% CI −0.7 to +4.7 min). Implementation significantly decreased the hospital admission rate for ED A (17.8% pre to 17.0% post [−0.8%], 95% CI −0.18% to 0.15%; p < 0.05) and did not significantly change the hospital admission rate at ED B (18.9% pre to 18.3% post [−0.6%], 95% CI −1.19% to −0.09%; p = 0.09).ConclusionsA multi-diagnosis OU can reduce hospital admission rate in a site-specific manner. In contrast to previous studies, we did not find that an OU reduced ED LOS. Further research is needed to determine whether OUs can reduce ED overcrowding.



http://ift.tt/2cADtc5

Malpractice Litigation and Testicular Torsion in the Spanish Setting: Lessons to Learn

Publication date: Available online 27 September 2016
Source:The Journal of Emergency Medicine
Author(s): Esperanza Luisa Gómez-Durán, César Vargas-Blasco, Carles Martin-Fumadó, Roger Bruguera, Josep Benet-Travé, Josep Arimany-Manso




http://ift.tt/2ddtbfW

Catamenial Epilepsy: The Menstrual Cycle as a Clue to Predict Future Refractory Seizures

Publication date: Available online 27 September 2016
Source:The Journal of Emergency Medicine
Author(s): Basem F. Khishfe
BackgroundCatamenial epilepsy is defined as an increase in the frequency of seizures during a particular phase of the menstrual cycle. The increased seizure frequency is attributed to the cyclic variation and neuroactive properties of endogenous steroid hormones. It is estimated that more than one-third of women with epilepsy experience catamenial seizure exacerbation.Case ReportWe present the case of a young female patient who presented to the emergency department with an increase in seizure frequency that coincided with her menstrual cycle, despite complete medication compliance.Why Should an Emergency Physician Be Aware of This?It is important for the emergency physician to consider catamenial epilepsy in the differential diagnosis for secondary causes of seizure to ensure appropriate follow-up, as well as improve the quality of life of patients suffering from uncontrolled seizures.



http://ift.tt/2cAEgKl

Radial Head Subluxation: Factors Associated with Its Recurrence and Radiographic Evaluation in a Tertiary Pediatric Emergency Department

Publication date: Available online 27 September 2016
Source:The Journal of Emergency Medicine
Author(s): Kei Wong, Alex B. Troncoso, Diane P. Calello, David Salo, Fred Fiesseler
BackgroundRadial head subluxation (RHS) is a common complaint seen in the pediatric emergency department in children ages 6 months to 4 years. Classically, injury occurs due to axial traction on the arm, but this mechanism is not universal. Some patients will have recurrent RHS; some may undergo x-ray (XR) evaluation for alternative diagnosis.ObjectivesTo determine factors associated with recurrences and radiographic evaluations in RHS.MethodsA retrospective study with inclusion criteria: under 10 years of age with discharge diagnosis "nursemaid," "radial head," or "subluxation." We examined factors associated with RHS recurrences, circumstances when radiographic evaluations performed, physician's training background (pediatric vs. general emergency medicine), mechanisms of injury, and demographic factors including age, gender, and arm involved.ResultsIn 246 visits, median age was 27 months (interquartile range 16.1), with females comprising 55.7% (n = 137), and left-sided predominance (52%, n = 130). Mechanisms of injury were classified as "pull" (65.9%, n = 162), "non-pull" (15.9%, n = 39), and "unknown" (18.3%, n = 45). Eighteen patients with recurring RHS were more likely to be male (p = 0.008). In 61 visits where radiography was performed, patients were older (p = 0.03), with a higher frequency seen in non-pull and unknown mechanism (p = 0.0001). No significant difference was found in frequency of radiographs obtained in regard to physician training (p = 0.4660).ConclusionRHS can result from a myriad of mechanisms. We found that recurrence was more likely in male patients. Factors associated with radiographic evaluation included atypical mechanism, older age, and unclear history, regardless of physician training background.



http://ift.tt/2dpozlJ

Scholar : These new articles for Compost Science & Utilization are available online

@media screen and (max-width:400px) { .two .column, .two .left, .two .right{ max-width: 100% !important; } } @media screen and (min-width: 401px) and (max-width:620px){ .two .column, .two .left, .two .right { max-width: 100% !important; } }

The online platform for Taylor & Francis Online content New for Compost Science & Utilization and online now on Taylor & Francis Online: Original Article Sweet Pepper (Capsicum annuum L.) Organic Seedling Production: The Role of Compost, Cultivar, and Protein Hydrolyzate Elena Testani, Gabriele Campanelli, Fabrizio Leteo, Corrado Ciaccia, Stefano Canali & Fabio Tittarelli Pages: 1-8 | DOI: 10.1080/1065657X.2016.1219682 Explore the latest free access research relating to Sustainable Development Goal 15: Life on Land This message is personalised to your status as a society member. Please do not forward this email. To recommend content, please use the social sharing tools on the website. To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Pituitary function within the first year after traumatic brain injury or subarachnoid haemorrhage

Abstract

Purpose

Reports on long-term variations in pituitary function after traumatic brain injury (TBI) and subarachnoid haemorrhage (SAH) diverge. The aim of the current study was to evaluate the prevalence and changes in pituitary function during the first year after moderate and severe TBI and SAH and to explore the relation between pituitary function and injury variables.

Methods

Adults with moderate and severe TBI or SAH were evaluated at 10 days, 3, 6 and 12 months post-injury/illness. Demographic, clinical, radiological, laboratory, including hormonal data were collected.

Results

A total of 91 adults, 56 (15 women/41 men) with TBI and 35 (27 women/8 men) with SAH were included. Perturbations in pituitary function were frequent early after the event but declined during the first year of follow-up. The most frequent deficiency was hypogonadotrope hypogonadism which was seen in approximately 25 % of the patients. Most of the variations were transient and without clinical significance. At 12 months, two patients were on replacement with hydrocortisone, four men on testosterone and one man on replacement with growth hormone. No relations were seen between hormonal levels and injury variables.

Conclusions

Perturbations in pituitary function continue to occur during the first year after TBI and SAH, but only a few patients need replacement therapy. Our study could not identify a marker of increased risk of pituitary dysfunction that could guide routine screening. However, data demonstrate the need for systematic follow-up of pituitary function after moderate or severe TBI or SAH.

http://ift.tt/2cT0raJ

Cross-cultural and socio-demographic correlates of homophobic attitude among university students in three European countries

Abstract

Purpose

The aim of this study was to investigate homophobic attitudes in three European countries: Italy, Albania, and Ukraine. One thousand and forty-eight students were recruited in Italian (n = 766), Albanian (n = 180), and Ukrainian (n = 102) university centers.

Methods

A socio-demographic questionnaire and Homophobia Scale (HS) were administered by our staff.

Results

Cross-cultural and significant differences among Italian, Albanian, and Ukrainian students were found on the Homophobia Scale (HS; Italy: mean = 22.26 ± 16.73; Albania: mean = 38.15 ± 17.28; Ukraine: mean = 59.18 ± 16.23). The analysis of socio-demographic characteristics revealed that the male gender emerged as main predictor of homophobic attitude in all the three countries, although also a conservative political orientation and the religious belief predict higher homophobia levels in Italy and Albania, particularly.

Conclusions

This study revealed that in these European countries assessed, attitudes toward homosexuality are different. Ukrainians display higher levels of homophobia than Albanians and Italians, confirming the central role of cultural differences in homophobic attitudes. Nevertheless, some socio-demographic aspects such as identification as male have a similar influence on homophobic attitudes in all assessed populations.

http://ift.tt/2dhnrDH

Freestyle local perforator flaps for facial reconstruction: clinical experience and complications

Abstract

Background

Reconstruction of facial defects always represents a surgical challenge as functional and cosmetic outcomes must be taken into account more than any region of the body. The concept of freestyle perforator flaps has been developed to obtain a complete range of freedom in their movement to reach the defect. We present our clinical experience with facial perforator flaps, focusing on indications, surgical technique, and complications.

Methods

Thirty-one facial defects were reconstructed with freestyle local perforator flaps between January 2007 and November 2014. Doppler identification of perforator vessels preceded preoperative planning and the flap harvesting followed the dissection of perforator vessels.

Results

Twenty-two clinical cases had no complications. Four had venous congestion that resolved spontaneously, three had a distal 1/3 superficial necrosis, one suffered hematoma, and one had a 1/5 distal area of full thickness necrosis.

Conclusions

Freestyle perforator approach was applied to gain more freedom for facial reconstruction, allowing one-stage procedures and low donor site morbidity. Good anatomical understanding, precise planning, and meticulous technique can affect clinical results of perforator flaps in the face. A critical approach is essential to get better results.

Level of Evidence: Level IV, therapeutic study.

http://ift.tt/2cIzuZC

Microsurgical flaps in the treatment of thoracic radionecrosis: a case series

Abstract

Background

Radionecrosis of the thoracic wall is a late complication of radiotherapy mainly found in breast cancer patients. During the treatment of severe thoracic radionecrosis, the aggressive ablation of a large amount of damaged tissue is fundamental, making the use of healthy remote tissue provided by a free flap essential. However, most of the papers focusing in the reconstruction of this entity are dated or case reports. This article is intended to present the utility and results of reconstructive microsurgical techniques in these patients.

Methods

We carried out a retrospective review of the patients who underwent microsurgical reconstruction of extensive thoracic defects associated with radionecrosis in the period 2007 to 2012 in our centre. The variables studied were sex, age, size of the lesion, type of reconstructive procedure used, the postoperative evolution of the flap and the donor area, and the length of the hospital stay.

Results

Four patients with extensive thoracic defects associated with radionecrosis were included. After debridement, bone reconstruction was performed using a polytetrafluorethylene mesh, while soft tissue reconstruction was achieved using a free flap. One of the patients was reconstructed with a deep inferior epigastric perforator free (DIEP) flap and the rest with transverse myocutaneous gracilis (TMG) free flap. No flap-related complications were observed during the postoperative period.

Conclusions

The effects of radiation on soft tissues and bones are the cause of the increasing complexity of thoracic reconstruction. We believe that the use of free flaps to provide large amounts of tissue or cover particularly problematic areas can be an extremely useful tool for these patients.

Level of Evidence: Level V, therapeutic study.

http://ift.tt/2dhlYcL

Analysis of Practice Settings for Craniofacial Surgery Fellowship Graduates in North America

Publication date: Available online 27 September 2016
Source:Journal of Surgical Education
Author(s): Jason Silvestre, Christopher Runyan, Jesse A. Taylor
ObjectiveIn North America, the number of craniofacial surgery fellowship graduates is increasing, yet an analysis of practice settings upon graduation is lacking. We characterize the practice types of recent graduates of craniofacial fellowship programs in the United States and Canada.DesignA 6-year cohort of craniofacial fellows in the United States and Canada (2010-2016) were obtained from craniofacial programs recognized by the American Society of Craniofacial Surgery. Practice setting was determined at 1 and 3 years of postgraduation, and predictors of practice setting were determined.ResultsA total of 175 craniofacial surgeons were trained at 35 fellowship programs. At 1 year of postgraduation, 33.6% had an academic craniofacial position and 27.1% were in private practice (p = 0.361). A minority of graduates pursued additional fellowships (16.4%), nonacademic craniofacial positions (10.0%), academic noncraniofacial positions (5.7%), and international practices (7.1%). At 3 years of postgraduation, the percentage of graduates in academic craniofacial positions was unchanged (34.5% vs 33.6%, p = 0.790). The strongest predictors of future academic craniofacial practice were completing plastic surgery residency at a program with a craniofacial fellowship program (odds ratio = 6.78, p < 0.001) and completing an academic craniofacial fellowship program (odds ratio = 4.48, p = 0.020).ConclusionsA minority of craniofacial fellowship graduates practice academic craniofacial surgery. A strong academic craniofacial surgery background during residency and fellowship is associated with a future career in academic craniofacial surgery. These data may assist trainees choose training programs that align with career goals and educators select future academic surgeons.



http://ift.tt/2cz4RT1

The MacTRAUMA TTL Assessment Tool: Developing a Novel Tool for Assessing Performance of Trauma Trainees: Initial Reliability Testing

Publication date: Available online 27 September 2016
Source:Journal of Surgical Education
Author(s): Aussama Nassar, Angela Coates, Faiz Tuma, Forough Farrokhyar, Susan Reid
ObjectivesTo develop a novel assessment tool for trainees-led trauma resuscitation. Assess psychometric properties of the proposed tool. Evaluate feasibility and utility of the tool.IntroductionTrauma resuscitation is a structured and complex process involving unique sets of skills. There is currently no published structured formative evaluation tool for trauma trainees. Therefore, many trauma trainees rely upon limited, unstructured feedback on their performance. We developed a tool to assess trainee performance while leading a trauma resuscitation and to assist faculty in providing trainee feedback after the encounter.MethodsThis study was conducted in a level I trauma centre in Ontario, Canada. Principles of learning theories, literature review, and clinical expert opinions were used to design a tool to assess clinical competence required to lead the resuscitation. In total, 5 critical domains were identified. High-fidelity simulation-based environment was used to test interrater reliability using intraclass correlation coefficients. To gauge feasibility, practicality, and utility of the tool, an online survey was sent to raters and trainees at the end of the study.ResultsWe found "excellent" agreement for "initial critical assessment" domain (0.80) and "moderate to good" agreement for the "communication and leadership" (0.67) and "clinical performance" domains (0.53). "Poor" agreement was identified for the "decision-making" domain (0.33). The coefficients for individual items reached "good" agreement for 5 items, and "moderate" agreement for 8 items. Intraclass correlation coefficients for the remaining 7 items were "fair" or "poor." Most raters agreed that items in the medical training domain were not applicable. Feedback from raters and trainees confirmed the feasibility and acceptability of the tool for formative feedback, in addition to some suggestions to enhance the tool.ConclusionMacTrauma TTL assessment tool is a novel tool for formative feedback for trainees' performance during trauma resuscitation. Initial psychometric property testing is promising. Further reliability and validity testing of the modified tool is needed. The tool has been shown to be feasible and acceptable by both trainees and faculty as a formative assessment tool.



http://ift.tt/2doT4wL

Correlation of microvessel parameters in invasive ductal carcinoma breast and fibroadenomas: a morphometric study

Publication date: Available online 27 September 2016
Source:Annals of Diagnostic Pathology
Author(s): Dibyajyoti Boruah, Jasvinder K Bhatia, Abhishek Rai, V Srinivas, V S Nijhawan
IntroductionModifications of microvascular configuration are essential features encountered during the progression of breast tumours. Our objectives were to correlate morphometrically evaluated microvessel parameters [microvessel density(MVD), microvessel caliber(VC), microvessel cross sectional area(VCSA), percentage of total VCSA (%TVCSA) and total microvessel boundary density(TVBD)] with histological grades of invasive ductal carcinoma breast(IDC) and benign breast lesions.Materials and MethodsSixty cases of IDC presented with modified radical mastectomy and 20 benign breast fibro-adenomas were evaluated for various microvessel parameters, using CD34-immunostained histological sections by computerized image morphometry. Samples were divided into four histological groups: Benign, Grade1, Grade2 and Grade3; mean with standard deviation and range was evaluated for each group.ResultsHistological grades showed strong positive correlation with %TVCSA(ρ=0.773) and TVBD(ρ=0.811), moderate positive correlation with MVD(ρ=0.607), VC(ρ=0.609) and VCSA(ρ=0.616) when analyzed for all samples of the four groups. Except MVD, all parameters including age was the lowest (P<.001) for the benign group. Among the IDCs, differences of mean VC and VCSA were not significant; MVD, %TVCSA and TVBD were the lowest in Grade1 and the highest in Grade3. Upper cutoff values of benign lesions for: MVD was 155mm⁻², VC was 9.94μm, VCSA was 94.42μm², %TVCSA was 1.33 and TVBD was 4.37mm⁻¹.ConclusionTVBD included the information of microvessels concentration and size showed the best correlation with grades. MVD showed positive correlation with grades in the IDCs; but for the differentiation of benign from malignant, VC, VCSA, %TVCSA and TVBD showed excellent area under the ROC curve (AUC>0.990), unlike MVD (AUC=0.797).



http://ift.tt/2d6GTCr

GATA3 expression in clinically useful groups of breast carcinoma: a comparison with GCDFP15 and mammaglobin for identifying paired primary and metastatic tumors

Publication date: Available online 26 September 2016
Source:Annals of Diagnostic Pathology
Author(s): Yu-Qiong Yang, Shan-Ming Lu, Wen-Qin Zeng, Shou-Cheng Xie, Sheng-Jun Xiao
GATA3 has been recognized as the novel marker for identifying primary and metastatic breast carcinomas, consistently showing that GATA3 was significantly more sensitive than traditional marker GCDFP15 and Mammaglobin (MGB). However, clinically useful groups of breast carcinomas status were not identified, which was determining appropriate treatment strategy, affecting the prognosis. In this study, we undertook a comparative study of the marker GATA3 and GCDFP15 and MGB in clinically useful groups of paired primary and metastatic breast cancer. We retrieved 64 cases of matched primary and metastatic breast cancer from the surgical pathology archive at our institution. According to the emerging St. Gallen 2015 consensus, the clinically useful groups were divided into ER and/or PR (+), HER2 (−), abbreviated as A; ER and/or PR (+), HER2 (+), abbreviated as B; ER and PR (−), HER2 (+), abbreviated as C; ER, PR and HER2 (−), abbreviated as D; each group contained 16 cases (n=16). Tissue microarrays were created, with three 1-mm punch specimens from each case. The tissue microarrays were cut at a 4-μm thickness and stained with monoclonal antibodies to GATA3, GCDFP15 and MGB. Staining intensity (0~3+) and extent (0% to 100%) were scored with an H-score calculated (range, 0 to 300). Sensitivities by varying H-score cutoffs (any; ≥50; ≥150) for a positive result in the clinically useful groups of matched primary or metastatic breast cancer among GATA3, GCDFP15 and MGB. GATA3 was significantly more sensitive than GCDFP15 and MGB in a majority of paired primary or metastatic breast cancer groups, including all groups, A and B groups (P<.05) rather than C and D groups (P>.05). However, GATA3 in conjunction with GCDFP15 and MGB detection could improve the sensitivity of C group (P<.05) rather than D group (P>.05). Significantly, good coincidence was observed between primary and metastatic tumor GATA3 expression (kappa value =0.826>0.75) as compared with the coincidence of GCDFP15 (kappa value =0.492<0.75) and MGB (kappa value =0.593<0.75) (both P<.05). In conclusion, GATA3 expression did not show the same sensitivity for the clinically useful groups of breast cancer. GATA3 expression is positively correlated with ER-positive, PR-positive, and HER2-positive carcinomas. In addition, the matched primary and metastatic tumor expression of GATA3 show good coincidence. We propose the careful selection of GATA3 for identifying hormone receptor-negativity of breast cancer, especially in the case of triple-negative breast cancer.



http://ift.tt/2dwKV5D

Dermatofibrosarcoma protuberans: pathology, genetics and potential therapeutic strategies

Publication date: Available online 27 September 2016
Source:Annals of Diagnostic Pathology
Author(s): Khin Thway, Jonathan Noujaim, Robin L Jones, Cyril Fisher
Dermatofibrosarcoma protuberans (DFSP), the most common dermal sarcoma, is a malignant fibroblastic tumor most frequently arising in middle-aged adults. It is typically a low-grade sarcoma that grows slowly but has a high rate of local recurrence with low metastatic potential. DFSP is characterized by a specific translocation t(17;22)(q22;q13) leading to formation of COL1A1-PDGFB fusion transcripts. Histologically DFSP has characteristic morphology, of storiform islands of bland spindle cells, and immunohistochemically it shows diffuse expression of CD34. However, the morphology and immunoprofile can overlap with a variety of other soft tissue neoplasms. The preferred management of localized disease is wide surgical resection or Mohs micrographic surgery, while radiotherapy may be used for margin-positive disease where re-excision is not possible, or for inoperable disease. DFSP is generally regarded as refractory to conventional chemotherapy. Treatment options for systemic disease have been previously limited, but the PDGFβR, KIT and ABL inhibitor imatinib is now an option for effective systemic therapy. Continued insight into the tumorigenic molecular changes generated by the fusion oncogene may lead to further specific targeted treatments. We review DFSP, discussing the morphologic spectrum and variants, immunohistochemistry, molecular genetic findings, potential targeted treatments and the differential diagnosis.



http://ift.tt/2d6H6WD

A Comparison of Cancer Stem Cell Markers and Non-classical MHC Antigens in Colorectal Tumor and Non-Cancerous Tissues

Publication date: Available online 26 September 2016
Source:Annals of Diagnostic Pathology
Author(s): Rabia Bilge Özgül Özdemir, Alper Tunga Özdemir, Fatih Oltulu, Kamile Kurt, Gürkan Yiğittürk, Cengiz Kırmaz
Colorectal carcinoma (CRC) is one of the most fatal types of cancer in both women and men, and, unfortunately, patients are often diagnosed at an advanced stage. Cancer stem cells (CSCs) are associated with poor prognosis, metastasis and recurrence, as well as chemotherapy and radiotherapy resistance. Therefore, different treatment alternatives are needed to facilitate the elimination of CSCs. One such approach is immunotherapy; however, tumor cells can evade immune cells by alteration of the expression patterns of human leukocyte antigens (HLA). In this study, we immunohistochemically investigated the expression patterns of CSC-specific markers CD44, CD133, Nanog, and Oct3/4, and immunosuppressive molecules HLA-G and E in advanced CRC tumor tissues and non-cancerous colon biopsies. We found significantly increased CD44, Nanog, Oct3/4, HLA-G, and HLA-E expression in the CRC tumor tissues, compared to the non-cancerous colon biopsies. These findings suggest that some tumor cells may be CSC-like, and that the increased expression of HLA-G and HLA-E may be considered as an immune-evasive adaptation. Therefore, the non-classical major histocompatibility complex class Ib antigens HLA-G and HLA-E may be potential targets in the elimination of CRC-CSCs. However, more detailed studies are required to support our findings.



http://ift.tt/2dwMcJy

False positive results in diagnostic immunohistochemistry are related to horseradish peroxidase conjugates in commercially available assays

Publication date: Available online 26 September 2016
Source:Annals of Diagnostic Pathology
Author(s): Gerard Nuovo
False positive results in diagnostic immunopathology can lead to unnecessary treatments. The purpose of this study was to do a side-by-side comparison of ten different antibodies commonly used in the clinical laboratory altering only the horseradish peroxidase (HRP) conjugate. The automated Leica BOND-MAX platform was used to study serial sections from 203 tissues including controls compared in a blinded fashion using the HRP conjugates from Leica (Refine HRP), Ventana Medical Systems (Ultraview HRP), and Enzo Life Sciences (Polyview HRP). False positive results, defined as signal from cases known to not contain the target, were noted in 23/171 cases (13%) with the Leica HRP, 62/171 cases (36%) with the Ventana HRP, and no cases with the Enzo HRP. Each data set was performed simultaneously allocating one tray for each of the three different HRP conjugates. HER2/neu analysis from triple negative breast cancers were scored as positive by immunohistochemistry in 6/25 cases (24%) using either the Refine or Ultraview HRP and in 0/25 cases with the Enzo conjugate. It is concluded that false positive results in a wide spectrum of diagnostic immunopathology tests can occur in from 13 to 36% of cases with two commonly used commercial assays based on the HRP conjugate.



http://ift.tt/2d6FZpE

Novel strategies for targeting leukemia stem cells: sounding the death knell for blood cancer

Abstract

Background

Cancer stem cells (CSCs), also known as tumor-initiating cells (TICs), are characterized by high self-renewal and multi-lineage differentiation capacities. CSCs are thought to play indispensable roles in the initiation, progression and metastasis of many types of cancer. Leukemias are thought to be initiated and maintained by a specific sub-type of CSC, the leukemia stem cell (LSC). An important feature of LSCs is their resistance to standard therapy, which may lead to relapse. Increasing efforts are aimed at developing novel therapeutic strategies that selectively target LSCs, while sparing their normal counterparts and, thus, minimizing adverse treatment-associated side-effects. These LSC targeting therapies aim to eradicate LSCs through affecting mechanisms that control their survival, self-renewal, differentiation, proliferation and cell cycle progression. Some LSC targeting therapies have already been proven successful in pre-clinical studies and they are now being tested in clinical studies, mainly in combination with conventional treatment regimens.

Conclusions

A growing body of evidence indicates that the selective targeting of LSCs represents a promising approach to improve disease outcome. Beyond doubt, the CSC hypothesis has added a new dimension to the area of anticancer research, thereby paving the way for shaping a new trend in cancer therapy.

http://ift.tt/2dp5NuV

Scholar : Experimental and Therapeutic Medicine - Volume:12 Number:4

Visit our website

TABLE OF CONTENTS October 2016 Volume 12 Issue 4

Huntington's disease: Molecular basis of pathology and status of current therapeutic approaches (Review) Wen‑Juan Huang, Wei‑Wei Chen, Xia Zhang View Abstract ❯

Status epilepticus: Using antioxidant agents as alternative therapies (Review) Liliana Carmona‑Aparicio, Cecilia Zavala‑Tecuapetla, María González‑Trujano, Aristides Iii Sampieri, Hortencia Montesinos‑Correa, Leticia Granados‑Rojas, Esaú Floriano‑Sánchez, Elvia Coballase‑Urrutía, Noemí Cárdenas‑Rodríguez View Abstract ❯

Pain control by melatonin: Physiological and pharmacological effects (Review) Wei‑Wei Chen, Xia Zhang, Wen‑Juan Huang View Abstract ❯

Microwaves and Alzheimer's disease (Review) Xia Zhang, Wen-Juan Huang, Wei-Wei Chen View Abstract ❯

DNA methylation in spermatogenesis and male infertility (Review) Xiangrong Cui, Xuan Jing, Xueqing Wu, Meiqin Yan, Qiang Li, Yan Shen, Zhenqiang Wang View Abstract ❯

Molecular examination of bone marrow stromal cells and chondroitinase ABC‑assisted acellular nerve allograft for peripheral nerve regeneration Ying Wang, Hua Jia, Wen‑Yuan Li, Li‑Xin Guan, Lingxiao Deng, Yan‑Cui Liu, Gui‑Bo Liu View Abstract ❯

Alterations of caveolin‑1 expression in a mouse model of delayed cerebral vasospasm following subarachnoid hemorrhage Ye Xiong, Xue‑Min Wang, Ming Zhong, Ze‑Qun Li, Zhi Wang, Zuo‑Fu Tian, Kuang Zheng, Xian‑Xi Tan View Abstract ❯

Targeting CRMP‑4 by lentivirus‑mediated RNA interference inhibits SW480 cell proliferation and colorectal cancer growth Si‑Le Chen, Shi‑Rong Cai, Xin‑Hua Zhang, Wen‑Feng Li, Er‑Tao Zhai, Jian‑Jun Peng, Hui Wu, Chuang‑Qi Chen, Jin‑Ping Ma, Zhao Wang, Yu‑Long He View Abstract ❯

Osthole decreases renal ischemia-reperfusion injury by suppressing JAK2/STAT3 signaling activation Lin-Na Luo, De Xie, Xiao Zhang, Rong Jiang View Abstract ❯

Guided bone regeneration with local zoledronic acid and titanium barrier: An experimental study Serkan Dundar, Cem Ozgur, Ferhan Yaman, Omer Cakmak, Arif Saybak, Ibrahim Ozercan, Hilal Alan, Gokhan Artas, Onur Nacakgedigi View Abstract ❯

Specific clinical manifestations of Nocardia: A case report and literature review Songsong Yu, Jing Wang, Qiuhong Fang, Jixin Zhang, Fengcai Yan View Abstract ❯

Achievement of a target dose of bisoprolol may not be a preferred option for attenuating pressure overload‑induced cardiac hypertrophy and fibrosis Shizhao Xiang, Ning Zhang, Zheng Yang, Zhouyan Bian, Yuan Yuan, Qizhu Tang View Abstract ❯

Effect of glycerol on sustained insulin release from PVA hydrogels and its application in diabetes therapy Yunpeng Cai, Junyi Che, Minglu Yuan, Xiaohong Shi, Wei Chen, Wei‑En Yuan View Abstract ❯

Overexpression of LRIG1 regulates PTEN via MAPK/MEK signaling pathway in esophageal squamous cell carcinoma Xiaofang Jiang, Huiwu Li View Abstract ❯

Reversal effect and mechanism of Ginkgo biloba exocarp extracts in multidrug resistance of mice S180 tumor cells Bi‑Yuan Hu, Yun‑Hao Gu, Chen‑Jie Cao, Jun Wang, Dong‑Dong Han, Ying‑Chao Tang, Hua‑Sheng Chen, Aihua Xu View Abstract ❯

ATP-induced cardioprotection against myocardial ischemia/reperfusion injury is mediated through the RISK pathway Zhe-Xun Lian, Fang Wang, Jun-Hua Fu, Zuo-Yuan Chen, Hui Xin, Ru-Yong Yao View Abstract ❯

Diagnosing pyogenic, brucella and tuberculous spondylitis using histopathology and MRI: A retrospective study Tao Li, Tao Liu, Zhensong Jiang, Xingang Cui, Jianmin Sun View Abstract ❯

Rare case of disseminated fusariosis in a young patient with graft vs. host disease following an allogeneic transplant Alina Tanase, Anca Colita, Gabriel Ianosi, Daniela Neagoe, Daciana Branisteanu, Daniela Calina, Anca Docea, Aristidis Tsatsakis, Simona Ianosi View Abstract ❯

Rhodiola rosea, folic acid, zinc and biotin (EndEP®) is able to improve ejaculatory control in patients affected by lifelong premature ejaculation: Results from a phase I‑II study Tommaso Cai, Paolo Verze, Paolo Massenio, Daniele Tiscione, Gianni Malossini, Luigi Cormio, Giuseppe Carrieri, Vincenzo Mirone View Abstract ❯

Oncogenic role of epithelial cell transforming sequence 2 in lung adenocarcinoma cells Hongyi Tan, Xiaoshan Wang, Xiaogang Yang, Haitao Li, Ben Liu, Pinhua Pan View Abstract ❯

Downregulation of microRNA-132 indicates progression in hepatocellular carcinoma Xin Zhang, Wei Tang, Ruishan Li, Rongquan He, Tingqing Gan, Yihuan Luo, Gang Chen, Minhua Rong View Abstract ❯

Decorin reduces hypertrophic scarring through inhibition of the TGF‑β1/Smad signaling pathway in a rat osteomyelitis model Peng Wang, Xiangyan Liu, Peng Xu, Jialiang Lu, Runze Wang, Weidong Mu View Abstract ❯

Identification of hub genes and pathways associated with hepatocellular carcinoma based on network strategy Jun Liu, Ping Hua, Li Hui, Li‑Li Zhang, Zhen Hu, Ying‑Wei Zhu View Abstract ❯

Matrix metalloproteinase 14 participates in corneal lymphangiogenesis through the VEGF-C/VEGFR-3 signaling pathway Hai‑Tao Du, Ping Liu View Abstract ❯

Alien hand syndrome following corpus callosum infarction: A case report and review of the literature Xiaoyu Gao, Bing Li, Wenzheng Chu, Xuwen Sun, Chunjuan Sun View Abstract ❯

Effect of early enteral nutrition on patients with digestive tract surgery: A meta-analysis of randomized controlled trials Xiao‑Liang Shu, Kai Kang, Li‑Juan Gu, Yong‑Sheng Zhang View Abstract ❯

Emergency treatment and nursing of children with severe pneumonia complicated by heart failure and respiratory failure: 10 case reports Wanli Li, Xinjiang An, Mingyu Fu, Chunli Li View Abstract ❯

HBD‑3 regulation of the immune response and the LPS/TLR4‑mediated signaling pathway Chen Zhu, Ni‑Rong Bao, Shuo Chen, Jian‑Ning Zhao View Abstract ❯

Anti‑angiogenic effect of total saponins of Rhizoma Dioscorea nipponica on collagen induced‑arthritis in rats Xiu‑Jun Liang, Ya‑Chun Guo, Tong‑You Sun, Hong‑Ru Song, Ya‑Xian Gao View Abstract ❯

Increased soluble and membrane-bound PD-L1 contributes to immune regulation and disease progression in patients with tuberculous pleural effusion Xue Pan, Anyuan Zhong, Yufei Xing, Minhua Shi, Bin Qian, Tong Zhou, Yongjing Chen, Xueguang Zhang View Abstract ❯

Sulfated polysaccharide‑protein complex sensitizes doxorubicin‑induced apoptosis of breast cancer cells in vitro and in vivo Jie Wang, Hua Wu, Chao Zhou, Hao Wang View Abstract ❯

Acetylsalicylic acid combined with diclofenac inhibits cartilage degradation in rabbit models of osteoarthritis Jianqiang Liu, Changshun Wu, Dong Wang, Laicheng Wang, Shui Sun View Abstract ❯

Branch retinal artery occlusion following carotid stenting: A case report Ran Sun, Xiao‑Yan Peng, Qi‑Sheng You, Li‑Qun Jiao, Da‑Chuan Liu View Abstract ❯

Rotavirus‑associated immune thrombocytopenic purpura in children: A retrospective study Qi Ai, Jing Yin, Sen Chen, Lijin Qiao, Na Luo View Abstract ❯

Decorin inhibits the proliferation of HepG2 cells by elevating the expression of transforming growth factor‑β receptor II Yanfeng Liu, Xuesong Wang, Zhaohui Wang, Wenbo Ju, Dawei Wang View Abstract ❯

Biological significance of PinX1 telomerase inhibitor in esophageal carcinoma treatment Xiang‑Kui Fan, Rui‑Hua Yan, Xiang‑Qun Geng, Jing‑Shan Li, Xiang‑Ming Chen, Jian‑Zhe Li View Abstract ❯

Gelatin sponge microparticles for the treatment of the spontaneous rupture of hepatocellular carcinoma hemorrhage Pu Wu, Jun Zhou, Yue Zhang View Abstract ❯

C1 inhibitor‑mediated myocardial protection from chronic intermittent hypoxia‑induced injury Jinrong Fu, Furong Guo, Cheng Chen, Xiaoman Yu, Ke Hu, Mingjiang Li View Abstract ❯

Diagnostic values of red cell distribution width, platelet distribution width and neutrophil‑lymphocyte count ratio for sepsis Hui‑Bing Zhang, Juan Chen, Qiao‑Fen Lan, Xiong‑Jian Ma, Shi‑Yan Zhang View Abstract ❯

Microarray analysis reveals altered circulating microRNA expression in mice infected with Coxsackievirus B3 Chaoyu Sun, Lei Tong, Wenran Zhao, Yan Wang, Yuan Meng, Lexun Lin, Bingchen Liu, Yujia Zhai, Zhaohua Zhong, Xueqi Li View Abstract ❯

Fulminant bilateral acute retinal necrosis syndrome associated with viral encephalitis: A case report Chunkui Zhou, Lijun Zhu, Shaokuan Fang View Abstract ❯

Tissue injuries after single-port and multiport laparoscopic gynecologic surgeries: A prospective multicenter study Kyeong So, Jae Lee, Jae Song, Jae Kim, Nak Lee, Kyung‑Do Ki, Jong‑Min Lee, Yong Song, Yong Na, Chun Ku, Jin Shin, Chul Kim, Un Jung View Abstract ❯

Mediastinal syndrome: A report of three cases Enrico Zardi, Maria Pipita, Antonella Afeltra View Abstract ❯

Endothelium-dependent and-independent relaxation induced by resveratrol in rat superior mesenteric arteries Yulong Chen, Cangbao Xu, Yahui Wei, Yaping Zhang, Ailan Cao View Abstract ❯

Homocysteine injures vascular endothelial cells by inhibiting mitochondrial activity Fengyong Yang, Xiujing Qi, Zheng Gao, Xingju Yang, Xingfeng Zheng, Chonghao Duan, Jian Zheng View Abstract ❯

Chronic myelocytic leukemic fundus lesion: A case report Le Xu, Yinghua Zhang, Yan Liu, Yan Ding View Abstract ❯

siRNA‑mediated silencing of phosphodiesterase 4B expression affects the production of cytokines in endotoxin‑stimulated primary cultured microglia Hao Cheng, Zhifang Wu, Xiaoyun He, Qingzhen Liu, Hongbin Jia, Yan Di, Qing Ji View Abstract ❯

Analysis of the first therapeutic-target-achieving time of warfarin therapy and associated factors in patients with pulmonary embolism Xiaowei Gong, Haiyan Wang, Yadong Yuan View Abstract ❯

Role of nucleolar protein NOM1 in pancreatic islet β cell apoptosis in diabetes Leilei Yu, Huifeng Wang, Zhongxiu Guo, Fenghua Li, Hong Cui View Abstract ❯

Clinical characteristics and analysis of familial oral lichen planus in eight Chinese families Shu‑Lai Lu, Xiang‑Min Qi, Gang Dong, Shu‑Lan Chen, Da‑Wei Guo, Yun‑Long Wang, Pi‑Shan Yang View Abstract ❯

Assessment of myocardial viability with delayed‑enhancement MRI in coronary artery disease: A correlative study with coronary artery stenosis using digital subtraction angiography Xinxiang Zhao, Yanglin Zhang, Yong Sun, Lin Sun, Renhui Cai View Abstract ❯

Evaluation of the effects of ketamine on spinal anesthesia with levobupivacaine or ropivacaine Yan Zhang, Hong Lin, Wen‑Bo Yi View Abstract ❯

Partial response to imatinib treatment in a patient with unresectable gastrointestinal stromal tumor: A case report and mini literature review Xiaolong Wu, Libo Feng, Qing Liu, Dong Xia, Liang Xu View Abstract ❯

Influencing factors of transient elastography in detecting liver stiffness Rong Shan, Hong Yin, Wenjuan Yang, Jianzhi Li, Meifang Zhang, Min Zhao, Jiang Shao, Aiguang Wang View Abstract ❯

Triptolide inhibits the progression of atherosclerosis in apolipoprotein E−/− mice Longfeng Luo, Tianlun Yang View Abstract ❯

Surgical treatment of incarcerated calculi via laparoscopic bile duct exploration using laparotomy biliary lithotomy forceps H. Jiang, S. Wang, X. Jin, J. Jin, H. Gu, F. Zhang View Abstract ❯

Quality evaluation of Heshouwu, a Taoist medicine in Wudang, China Hongliang Li, Shuqiang Cao, Xuanbin Wang, Qimin Zuo, Ping Chen, Ying Liu, Ming Liu, Yibin Feng, Xincai Hao, Longchao Xiang, Xiaohua Zeng View Abstract ❯

Recombinant expression and biological characterization of the antimicrobial peptide fowlicidin‑2 in Pichia pastoris Li‑Wei Xing, Shi‑Xun Tian, Wei Gao, Na Yang, Pei Qu, Di Liu, Jian Jiao, Jue Wang, Xing‑Jun Feng View Abstract ❯

Acute transverse myelitis and subacute thyroiditis associated with dengue viral infection: A case report and literature review Zhiming Mo, Yaxian Dong, Xiaolian Chen, Huiyan Yao, Bin Zhang View Abstract ❯

FeNO for detecting lower airway involvement in patients with allergic rhinitis Zheng Zhu, Yanqing Xie, Weijie Guan, Yi Gao, Shu Xia, Nanshan Zhong, Jinping Zheng View Abstract ❯

Role of PiCCO monitoring for the integrated management of neurogenic pulmonary edema following traumatic brain injury: A case report and literature review Xiaoping Lin, Zhijun Xu, Pengfei Wang, Yan Xu, Gensheng Zhang View Abstract ❯

C/EBP β mRNA expression is upregulated and positively correlated with the expression of TNIP1/TNFAIP3 in peripheral blood mononuclear cells from patients with systemic lupus erythematosus Tian Qian, Yan Chen, Xiaowei Shi, Jian Li, Fei Hao, Dongmei Zhang View Abstract ❯

Parasitic infection as a potential therapeutic tool against rheumatoid arthritis (Review) Shadike Apaer, Tuerhongjiang Tuxun, Hai‑Zhang Ma, Heng Zhang, Amina Aierken, Abudusalamu Aini, Yu‑Peng Li, Ren‑Yong Lin, Hao Wen View Abstract ❯

Childhood type 2 diabetes: Risks and complications (Review) Ying Xue, Min Gao, Yiqing Gao View Abstract ❯

Use of deep brain stimulation for major affective disorders (Review) Kuanqing Mi View Abstract ❯

Hypersplenism: History and current status (Review) Yunfu Lv, Wan Lau, Yejuan Li, Jie Deng, Xiaoyu Han, Xiaoguang Gong, Ning Liu, Hongfei Wu View Abstract ❯

Pediatric rhinitis risk factors (Review) Yaofeng Ji, Yin Liu, Na Yang View Abstract ❯

Effectiveness of palliative care for non-small cell lung cancer (Review) Huiqin Li, Jianing Li View Abstract ❯

Metabolic syndrome in children (Review) Yue‑E Wu, Chong‑Lin Zhang, Qing Zhen View Abstract ❯

Obesity and hypertension (Review) Shu‑Zhong Jiang, Wen Lu, Xue‑Feng Zong, Hong‑Yun Ruan, Yi Liu View Abstract ❯

Neurological teratogenic effects of antiepileptic drugs during pregnancy (Review) Qingmei Nie, Baohua Su, Jianping Wei View Abstract ❯

Telemedicine in clinical setting (Review) Xiao-Ying Zhang, Peiying Zhang View Abstract ❯

Hospital information technology in home care (Review) Xiao-Ying Zhang, Pei-Ying Zhang View Abstract ❯

Blood-filled cerebrospinal fluid-enhanced pericyte microvasculature contraction in rat retina: A novel in vitro study of subarachnoid hemorrhage Zhi Liu, Qiang Li, Gaoyu Cui, Gang Zhu, Weihua Tang, Hengli Zhao, John Zhang, Yujie Chen, Hua Feng View Abstract ❯

Systemic and local zoledronic acid treatment with hydroxyapatite bone graft: A histological and histomorphometric experimental study Nedim Günes, Serkan Dundar, Arif Saybak, Gökhan Artas, Izzet Acikan, I. Ozercan, Serhat Atilgan, Ferhan Yaman View Abstract ❯

Small hepatocyte-like progenitor cells may be a Hedgehog signaling pathway-controlled subgroup of liver stem cells Zhibin Wang, Wei Li, Chun Li, Yang Yang, Wang Li, Liying Zhang, Shumei Sun, Junxiang Li, Yidong Cai View Abstract ❯

Clinical evaluation of ultrasound screening in follow-up visits of infants with cerebral palsy at high risk for developmental dysplasia of the hip Aizhen Qiu, Zhongxiu Yang, Jiping Wang, Taotao Wang View Abstract ❯

Concomitant presentation of Anderson-Tawil syndrome and myasthenia gravis in an adult patient: A case report Rui Fan, Ruirui Ji, Wenxin Zou, Guoliang Wang, Hu Wang, Daniel Penney, Jin Luo, Yuxin Fan View Abstract ❯

Computational approach for predicting the conserved B-cell epitopes of hemagglutinin H7 subtype influenza virus Xiangyu Wang, Qi Sun, Zhonghua Ye, Ying Hua, Na Shao, Yanli Du, Qiwei Zhang, Chengsong Wan View Abstract ❯

Mesenchymal stem cells with irreversibly arrested proliferation stimulate decidua development in rats Alisa Domnina, Polina Novikova, Olga Lyublinskaya, Valeriy Zenin, Irina Fridlyanskaya, Vyacheslav Mikhailov, Nikolay Nikolsky View Abstract ❯

Co-expressed differentially expressed genes and long non-coding RNAs involved in the celecoxib treatment of gastric cancer: An RNA sequencing analysis Bin Song, Juan Du, Ye Feng, Yong‑Jian Gao, Ji‑Sheng Zhao View Abstract ❯

IL-35 improves Treg-mediated immune suppression in atherosclerotic mice Linlin Tao, Jie Zhu, Yuefeng Chen, Qinghang Wang, Ying Pan, Qianqian Yu, Birong Zhou, Huaqing Zhu View Abstract ❯

Randomized, double-blind, placebo-controlled superiority trial of the Yiqigubiao pill for the treatment of patients with chronic obstructive pulmonary disease at a stable stage Feng‑Sen Li, Yan‑Li Zhang, Zheng Li, Dan Xu, Chun‑Yan Liao, Huan Ma, Li Gong, Jun Su, Qi Sun, Qian Xu, Zhen Gao, Ling Wang, Jing Jing, Jing Wang, Min Jiang, Ge Tian, Bilal Hasan View Abstract ❯

A meta-analysis of the effects of β-adrenergic blockers in chronic heart failure Xiaojian Zhang, Chengwu Shen, Shujun Zhai, Yukun Liu, Wen‑Wei Yue, Li Han View Abstract ❯

Association between insulin resistance and estrogen in sexual precocity of obese children Shixia Lin, Wei Ji View Abstract ❯

Effects of phacoemulsification and intraocular lens implantation combined with ciliarotomy in the treatment of angle-closure glaucoma with cataract Bo Li, Feng‑Yun Wang, Tai‑Liang Lv, Yu Zhu View Abstract ❯

Diffusion tensor imaging of occult injury of optic radiation following optic neuritis in multiple sclerosis Jiafeng Chen, Lijun Zhu, He Li, Ziwen Lu, Xin Chen, Shaokuan Fang View Abstract ❯

Effect of adefovir dipivoxil on T cell immune function in the treatment of chronic hepatitis B and hepatocirrhosis Liting Tian, Qilin Fu, Fu Huang View Abstract ❯

Serum biomarkers combined with uterine artery Doppler in prediction of preeclampsia Lijie Li, Yanmei Zheng, Ying Zhu, Jianchun Li View Abstract ❯

Influence of random urine albumin-creatinine ratio of pregnant women with hypertension during the gestation period on perinatal outcome Qian Yan, Hongmei Wang, Ronghui Liu, Ling Jiang, Jingying Liu, Lijuan Wang, Yuanying Guo View Abstract ❯

Local application of low-dose insulin in improving wound healing after deep burn surgery Chejiang Wang, Jiazhe Wang, Jianke Feng View Abstract ❯

Oral paracetamol vs. oral ibuprofen in the treatment of symptomatic patent ductus arteriosus in premature infants: A randomized controlled trial Bo Yang, Xiangyu Gao, Yi Ren, Yun Wang, Qinglin Zhang View Abstract ❯

LSKL peptide alleviates subarachnoid fibrosis and hydrocephalus by inhibiting TSP1-mediated TGF-β1 signaling activity following subarachnoid hemorrhage in rats Fan Liao, Gaofeng Li, Wen Yuan, Yujie Chen, Yuchun Zuo, Kauthar Rashid, John Zhang, Hua Feng, Fei Liu View Abstract ❯

Application of levator veli palatini retropositioning combined with Buccinator myomucosal island flap for congenital cleft palate Y. Wan, H. Zhang, Y. Zhang, Y. Cheng, Y. Zhang , C. Wang View Abstract ❯

Role of the renal sympathetic nerves in renal sodium/potassium handling and renal damage in spontaneously hypertensive rats Jianling Li, Qiaoling He, Weifeng Wu, Qingjie Li, Rongjie Huang, Xiaofeng Pan, Wenying Lai View Abstract ❯

Mucosa-reparing and microbiota-balancing therapeutic effect of Bacillus subtilis alleviates dextrate sulfate sodium-induced ulcerative colitis in mice Hui‑Lu Zhang, Wen‑Shuai Li, Dian‑Nan Xu, Wan‑Wei Zheng, Yi Liu, Jian Chen, Zhi‑Bing Qiu, Robert Dorfman, Jun Zhang, Jie Liu View Abstract ❯

Ginsenoside Rb1 protects the intestinal mucosal barrier following peritoneal air exposure Feng Zhou, Peichen Zhang, Xiaoxi Chen, Jingyi Yan, Jiangao Yao, Zhen Yu, Xiaolei Chen View Abstract ❯

Effect of systemic injection of heterogenous and homogenous opioids on peripheral cellular immune response in rats with bone cancer pain: A comparative study Jun‑Ying Du, Yi Liang, Jun‑Fan Fang, Yong‑Liang Jiang, Xiao‑Mei Shao, Xiao‑Fen He, Jian‑Qiao Fang View Abstract ❯

Delayed protective effect of telmisartan on lung ischemia/reperfusion injury in valve replacement operations Yongfeng Fan, Daguo Zhang, Daokang Xiang View Abstract ❯

Part of plasmapheresis with plasma filtration adsorption combined with continuous hemodiafiltration in the treatment of severe acute liver failure Maoqin Li, Zhidong Wang, Yining Wang, Changhong Du, Songhai Li, Zaixiang Shi, Bo Lu View Abstract ❯

Aminoglycoside antibiotics for NIH category II chronic bacterial prostatitis: A single-cohort study with one-year follow-up Vittorio Magri, Emanuele Montanari, Emanuela Marras, Gianpaolo Perletti View Abstract ❯

TFP5 prevents 1-methyl-4-phenyl pyridine ion-induced neurotoxicity in mouse cortical neurons Qi‑Shan Zhang, Yuan‑Gao Liao, Zhong Ji, Yong Gu, Hai‑Shan Jiang, Zuo‑Shan Xie, Su‑Yue Pan, Ya‑Fang Hu View Abstract ❯

Expression of Toll-like receptor 4 in lungs of immune-suppressed rat with Acinetobacter baumannii infection Yanmei Wang, Xiaohong Zhang, Xuanlin Feng, Xiaoshu Liu, Lei Deng, Zong-An Liang View Abstract ❯

Clinical characteristics of drug-induced liver injury and related risk factors Ren‑Jie Lu, Yan Zhang, Feng‑Lei Tang, Zhong‑Wei Zheng, Zheng‑Da Fan, Shan‑Mei Zhu, Xian‑Feng Qian, Na‑Na Liu View Abstract ❯

Observation on therapeutic efficacy of rt-PA intravenous thrombolysis combined with compound anisodine injection on central retinal artery occlusion Xiao-Jun Wu, Feng Gao, Xu Liu, Qing Zhao View Abstract ❯

Protective effects of dexmedetomidine combined with flurbiprofen axetil on remifentanil-induced hyperalgesia: A randomized controlled trial Zenggui Yu, Weilan Wu, Xiaodan Wu, Hongyi Lei, Cansheng Gong, Shiyuan Xu View Abstract ❯

Association of genetic polymorphisms of GALNT3 and VDR with osteoporosis in postmenopausal women Guorong Wang, Junhua Yang, Xun Zheng, Jiahua Zhu, Wangqing Shi, Aimin Chen, Guoxian Chen, Fangye Zhou View Abstract ❯

Establishment of ApoE-knockout mouse model of preeclampsia and relevant mechanisms Wenjuan Sun, Baoxia Cui, Fanzhen Hong, Yongping Xu View Abstract ❯

National trends in carotid endarterectomy and stenting in Korea from 2004 to 2013 Sung‑Shin Cho, Jin Joh, Hyung‑Joon Ahn, Ho‑Chul Park View Abstract ❯

Effect of pioglitazone on neuropathic pain and spinal expression of TLR-4 and cytokines Hongbin Jia, Shuangshuang Xu, Qingzhen Liu, Jian Liu, Jianguo Xu, Weiyan Li, Yi Jin, Qing Ji View Abstract ❯

MicroRNA-129-5p inhibits vascular smooth muscle cell proliferation by targeting Wnt5a Yiming Zhang, Zhao Liu, Min Zhou, Changjian Liu View Abstract ❯

Association between socioeconomic status and oral health behaviors: The 2008-2010 Korea national health and nutrition examination survey Jun‑Beom Park, Kyungdo Han, Yong‑Gyu Park, Youngkyung Ko View Abstract ❯

Multimodal imaging findings of SAPHO syndrome with no skin lesions: A report of three cases and review of the literature Na Duan, Xiao Chen, Yongkang Liu, Jianhua Wang, Zhongqiu Wang View Abstract ❯

Identification of the protective effects of traditional medicinal plants against SDS-induced Drosophila gut damage Yang Zhou, Zonglin Liu, Yuchen Chen, Li Jin View Abstract ❯

Effect of Polygonatum odoratum extract on human breast cancer MDA-MB-231 cell proliferation and apoptosis Yu Tai, Yi‑Ming Sun, Xue Zou, Qiong Pan, Ya‑Dong Lan, Qiang Huo, Jing‑Wen Zhu, Fei Guo, Chang‑Quan Zheng, Cheng‑Zhu Wu, Hao Liu View Abstract ❯

Neural stem cell transplantation combined with erythropoietin for the treatment of spinal cord injury in rats Yan Zhao, Yuan Zuo, Jianming Jiang, Huibo Yan, Xiliang Wang, Hunjun Huo, Yulong Xiao View Abstract ❯

Long-term health effects of persistent exposure to low-dose lr192 gamma-rays Hongbo Li, Lin Wang, Zujun Jiang, Li Li, Zhifang Xiao, Zenghui Liu, Shuang Zhang, Hui Jin, Lei Su, Yang Xiao View Abstract ❯

Astragaloside IV ameliorates necrotizing enterocolitis by attenuating oxidative stress and suppressing inflammation via the vitamin D3-upregulated protein 1/NF-κB signaling pathway Zhiyong Cai, Jindi Liu, Hongliang Bian, Jinlan Cai View Abstract ❯

Anticancer effect of cucurbitacin B on MKN-45 cells via inhibition of the JAK2/STAT3 signaling pathway You‑Li Xie, Wen‑Hui Tao, Ti‑Xiong Yang, Jian‑Guo Qiao View Abstract ❯

Screening and identification of microRNA involved in unstable angina using gene-chip analysis Si Li, Ya‑Nan Sun, Yun‑Tao Zhou, Chun‑Lai Zhang, Feng Lu, Jia Liu, Xiao‑Ming Shang View Abstract ❯

Expression and regulation of the ery operon of Brucella melitensis in human trophoblast cells Hui Zhang, Xiaoxia Dou, Zhiqiang Li, Yu Zhang, Jing Zhang, Fei Guo, Yuanzhi Wang, Zhen Wang, Tiansen Li, Xinli Gu, Chuangfu Chen View Abstract ❯

Scrub typhus associated with hemophagocytic lymphohistiocytosis: A report of six pediatric patients Yingkang Jin, Li Huang, Huifeng Fan, Gen Lu, Yi Xu, Zhiyuan Wu View Abstract ❯

Shikonin inhibits inflammation and chondrocyte apoptosis by regulation of the PI3K/Akt signaling pathway in a rat model of osteoarthritis Daijie Fu, Xifu Shang, Zhe Ni, Guoguang Shi View Abstract ❯

Tanshinone IIA pretreatment attenuates ischemia/reperfusion-induced renal injury Yan‑Mei Xu, Guo‑Hua Ding, Jie Huang, Yan Xiong View Abstract ❯

miR-448 downregulates MPPED2 to promote cancer proliferation and inhibit apoptosis in oral squamous cell carcinoma Linhan Shen, Liu Liu, Liangyu Ge, Long Xie, Siyu Liu, Lei Sang, Tiantian Zhan, Hongwei Li View Abstract ❯

FOXP3+ associated with the pro-inflammatory regulatory T and T helper 17 effector cells in asthma patients Jian‑Guo Zhang, Xiao‑Juan Chen, Tao Liu, Shu‑Juan Jiang View Abstract ❯

Expression and location of HSP60 and HSP10 in the heart tissue of heat-stressed rats Yanfen Cheng, Jiarui Sun, Hongbo Chen, Abdelnasir Adam, Shu Tang, Nicole Kemper, Jörg Hartung, Endong Bao View Abstract ❯

Clinicopathological characteristics of thyroid cancer misdiagnosed by fine needle aspiration Hideki Maeda, Goro Kutomi, Fukino Satomi, Hiroaki Shima, Mitsuru Mori, Koichi Hirata, Ichiro Takemasa View Abstract ❯

Gemstone spectral imaging for measuring adult bone mineral density Wei‑Guang Shao, Dian‑Mei Liu View Abstract ❯

Increased receptor activator of nuclear factor κβ ligand/osteoprotegerin ratio exacerbates cartilage destruction in osteoarthritis in vitro Ji‑Zhou Zeng, Zhen‑Zhong Wang, Li‑Feng Ma, Hai Meng, Hao‑Miao Yu, Wen‑Hao Cheng, Ya‑Kui Zhang, Ai Guo View Abstract ❯

OMP31 of Brucella melitensis 16M impairs the apoptosis of macrophages triggered by TNF-α Ke Zhang, Hui Wang, Fei Guo, Li Yuan, Wanjiang Zhang, Yuanzhi Wang, Chuangfu Chen View Abstract ❯

Anti-inflammatory activity of liposomes of Asparagus racemosus root extracts prepared by various methods Nathsiree Plangsombat, Kanin Rungsardthong, Lalana Kongkaneramit, Neti Waranuch, Narong Sarisuta View Abstract ❯

6-8 October, 2016, Metropolitan Hotel, Athens, Greece 21st World Congress on Advances in Oncology & 19th International Symposium on Molecular Medicine

Follow Us

Fax: +30 210 725 2922 Tel: +30 210 722 7809 Email: contact@spandidos-publications.com Website: http://ift.tt/1nR9dcA

You have been sent this Table of Contents because you have opted to receive it. You can change or discontinue your e-mail alerts at any time by modifying your preferences on your Spandidos Publications account.