Transparent reporting of experimental parameters in assays measuring phenotypic steps in metastasis

Abstract

Metastasis is key to cancer mortality. Understanding its biology is vital for developing strategies to prevent and treat metastasis. Phenotypic assays to either study metastasis or evaluate anti-metastatic drugs are widely used in preclinical research. This technical note discusses the adherence of reporting essential experimental and methodological parameters in chemotactic invasion assays in vitro and spontaneous metastasis assays in vivo. Following the analysis of 130 recent (< 5 years) research papers, several shortcomings in reporting were identified. Therefore, we strongly argue to increase experimental rigor which should result in a significant improvement with respect to reproducibility of preclinical metastasis research.

https://ift.tt/2AuKeqv

Associations among regorafenib concentrations, severe adverse reactions, and ABCG2 and OATP1B1 polymorphisms

Abstract

Purpose

The ability of predicting severe adverse reactions caused by regorafenib is important. We evaluated regorafenib concentrations for adverse reaction risks and assessed the relevance of laboratory values and gene polymorphisms.

Methods

A total of 28 Japanese cancer patients who were treated with regorafenib were evaluated for the steady state of serum regorafenib concentrations and adverse reactions for 28 days. In addition, we determined the association of regorafenib concentrations with ABCG2 and OATP1B1 polymorphisms, which are regorafenib transporters.

Results

Regorafenib concentrations were significantly higher in the group with Grade 2 or higher total bilirubin elevation and thrombocytopenia compared with the group with grades 0 or 1 [3.45 (2.18–7.31) vs. 1.76 (0.26–2.77) µg/mL, P = 0.01 and 3.45 (2.12–7.31) vs. 1.76 (0.26–2.77) µg/mL, P = 0.02, respectively]. A strong association was noted between serum regorafenib concentrations and total bilirubin levels, but the physical and genetic factors predicting regorafenib pharmacokinetics could not be clarified.

Conclusions

Regorafenib concentrations were associated with total bilirubin elevation and thrombocytopenia. Total serum bilirubin could be a useful marker when estimating regorafenib pharmacokinetics.

https://ift.tt/2yAsl8o

Phase I study of BNC105P, carboplatin and gemcitabine in partially platinum-sensitive ovarian cancer patients in first or second relapse (ANZGOG-1103)

Abstract

Purpose

The primary objective of this study was to determine the recommended dose of the vascular disrupting agent, BNC105P, in combination with gemcitabine and carboplatin in patients with ovarian cancer in first or second relapse with a minimum 4 month progression-free interval after last platinum.

Methods

Patients received carboplatin AUC4 on day 1 in combination with escalating doses of 800 or 1000 mg/m² gemcitabine on days 1 and 8 and escalating doses of 12 or 16 mg/m² BNC105P on days 2 and 9 every 21 days for a maximum for six cycles. Maintenance treatment with 16 mg/m² BNC105P treatment continued for a maximum of six additional cycles. Patients were followed for safety and anti-tumor activity.

Results

Fifteen patients were enrolled in the study. Adverse events were most commonly of hematological origin. Dose-limiting toxicities (thrombocytopenia and neutropenia) occurred in two patients at the dose level of 800 mg/m² gemcitabine, carboplatin AUC4 and 16 mg/m² BNC105P. No dose-limiting toxicities were observed at a dose level of gemcitabine 1000 mg/m², carboplatin AUC4 and BNC105P 12 mg/m². BNC105P as a single agent was well tolerated at a dose of 16 mg/m² in maintenance treatment. Ten patients (67%) achieved a complete or partial response according to CA125 and/or RECIST response criteria, four of 13 (31%) responded by RECIST alone. The median progression-free survival was 5.9 months.

Conclusions

We have established that BNC105P 12 mg/m² with gemcitabine 1000 mg/m² and carboplatin AUC4 is the recommended dose level and has an acceptable toxicity profile. Further exploration of BNC105P in the ovarian cancer setting is planned.

https://ift.tt/2CIDGWF

A case of an infant with extremely low birth weight and hypothyroidism associated with massive cutaneous infantile hemangioma

Journal Name: Journal of Pediatric Endocrinology and Metabolism
Issue: Ahead of print


https://ift.tt/2PXREaR

Cardiometabolic risk factors in preschool children with abdominal obesity from Medellín, Colombia

Journal Name: Journal of Pediatric Endocrinology and Metabolism
Issue: Ahead of print


https://ift.tt/2Aw3oMy

The prevalence and volumetry of pituitary cysts in children with growth hormone deficiency and idiopathic short stature

Journal Name: Journal of Pediatric Endocrinology and Metabolism
Issue: Ahead of print


https://ift.tt/2PXRzE5

Dear Dr. Dermatoethicist: Exam of the Future or Exam of Future Cheating? Ethical Issues Surrounding the American Board of Dermatology’s New Certification Examination

Publication date: Available online 27 October 2018

Source: Journal of the American Academy of Dermatology

Author(s): Reid A. Waldman, Jane M. Grant-Kels

https://ift.tt/2StEowy

Non-cultured epidermal suspension grafting using suction blisters as donor tissue for vitiligo

Publication date: Available online 27 October 2018

Source: Journal of the American Academy of Dermatology

Author(s): Andrea Tovar-Garza, Jorge A. Hinojosa, Linda S. Hynan, Amit G. Pandya

https://ift.tt/2z4Z70I

Benign subungual epidermoid inclusions

Publication date: Available online 27 October 2018

Source: Journal of the American Academy of Dermatology

Author(s): Josette André, Eckart Haneke

https://ift.tt/2SlU9Fz

Reply to "Benign subungual epidermoid inclusions"

Publication date: Available online 27 October 2018

Source: Journal of the American Academy of Dermatology

Author(s): Amélie Boespflug, Sébastien Debarbieux, Lauriane Depaepe, Brigitte Chouvet, Delphine Maucort-Boulch, Stéphane Dalle, Brigitte Balme, Luc Thomas

https://ift.tt/2zbWfz0

A Phase 2, Randomized Dose-Finding Study of Tapinarof (GSK2894512 Cream) for the Treatment of Plaque Psoriasis

Publication date: Available online 26 October 2018

Source: Journal of the American Academy of Dermatology

Author(s): Kevin Robbins, Robert Bissonnette, Tomoko Maeda-Chubachi, Li Ye, Johnny Peppers, Kelly Gallagher, John E. Kraus

Abstract

Background

There is a significant need for novel, safe and efficacious topical treatments for psoriasis.

Objective

We assessed the safety and efficacy of tapinarof in a new cream formulation in 2 concentrations and 2 application frequencies in adults with psoriasis.

Methods

Double-blind, vehicle-controlled, randomized, 6-arm trial (1:1:1:1:1:1) in adults, with psoriasis with body surface (BSA) involvement ≥1% and ≤15% and PGA ≥2 at Baseline. Primary endpoint included PGA = 0 or 1 at Week 12, and a 2-grade improvement from Baseline. Additional analyses included PASI75 and mean percent change in PASI and BSA.

Results

Treatment success defined by PGA 0 or 1 and a 2-Grade Improvement at Week 12 were statistically significantly higher (at a 0.05 significance level) in the tapinarof groups than the vehicle groups: (65% [1%BID]; 56% [1%QD]; 46% [0.5%BID]; 36% [0.5%QD]; 11% [vehicle BID], and 5% [vehicle QD]) and was maintained for 4 weeks post-treatment. Treatment-emergent adverse events (TEAEs) were higher with tapinarof (85/152 patients [56%] compared to vehicle 19/75 patients [25%]) and mild-to-moderate in intensity. Severe TEAEs were reported in all tapinarof groups except 0.5% QD.

Limitations

Large confirmation trials are needed.

Conclusions

Tapinarof cream is efficacious and well tolerated in adult patients with psoriasis.

https://ift.tt/2SoMC9d

Response to “A relapsing peeling of oral mucosa”

Publication date: Available online 26 October 2018

Source: Journal of the American Academy of Dermatology

Author(s): Andrea D. Maderal, Paul Lee Salisbury, Joseph L. Jorizzo

https://ift.tt/2z6Ng29

Histologic predictors of invasion in partially biopsied lentigo maligna melanoma

Publication date: Available online 26 October 2018

Source: Journal of the American Academy of Dermatology

Author(s): I. Aouidad, C. Fargeas, P. Romero, J.F. Sei, V. Chaussade, A. Beauchet, T. Clerici, U. Zimmermann, P. Saiag, E. Funck-Brentano

https://ift.tt/2SlTVhH

Classic Dermatological Tools: Foreign Body Removal with Punch Biopsy

Publication date: Available online 26 October 2018

Source: Journal of the American Academy of Dermatology

Author(s): Jesus Alberto Cardenas-de la Garza, Adrian Cuellar-Barboza, Jesus Ancer-Arellano, Cesar Jair Ramos-Cavazos, Osvaldo Tomas Vazquez-Martinez, Jorge Ocampo-Candiani

https://ift.tt/2z9OPMC

Markers of systemic involvement and death in hospitalized cancer patients with severe cutaneous adverse reactions

Publication date: Available online 26 October 2018

Source: Journal of the American Academy of Dermatology

Author(s): Shoko Mori, Alanna Hickey, Stephen W. Dusza, Mario E. Lacouture, Alina Markova

Abstract

Background

Severe cutaneous adverse reactions (SCARs) are frequent in inpatient oncology. Early intervention may reduce morbidity, mortality, and hospitalization costs, however current clinical and histologic features are unreliable SCAR predictors. There is a need to identify rational markers of SCARs that could lead to effective therapeutic interventions.

Objective

To characterize the clinical and serologic features of hospitalized patients with cancer who developed SCARs.

Methods

Retrospective review of 49 hospitalized cancer patients with a morbilliform rash and recorded testing for serum cytokines (IL-6, IL-10, TNF-α) or elafin, and prior dermatology consultation. Patients were categorized as having a 'simple' morbilliform rash without systemic involvement or 'complex' morbilliform rash with systemic involvement.

Results

Fifteen out of 49 patients (30.6%) were deceased at 6 months from time of dermatologic consultation. Elafin, IL-6, and TNF-α were significantly higher in patients who died compared to patients who were still alive at 6 months. IL-6 and IL-10 were significantly higher in patients with a drug-related 'complex' rash.

Limitations

Retrospective design, limited sample size, high-risk patient population.

Conclusion

In cancer patients with SCARs, elafin, IL-6, and TNF- α may predict a poor outcome. Agents directed towards these targets may represent rational treatments for the prevention of fatal SCARs.

https://ift.tt/2So1vZa

A relapsing peeling of oral mucosa

Publication date: Available online 26 October 2018

Source: Journal of the American Academy of Dermatology

Author(s): M.A. Chessa, E. Dika, G. Carlotta, B. Carlotta, A. Patrizi

https://ift.tt/2z3SX0O

Prognosticating autoimmune encephalitis: A systematic review

Publication date: Available online 26 October 2018

Source: Journal of Autoimmunity

Author(s): James Broadley, Udaya Seneviratne, Paul Beech, Katherine Buzzard, Helmut Butzkueven, Terence O'Brien, Mastura Monif

Abstract

Objective

To perform a systematic review of the current scientific literature in order to identify variables associated with patient prognosis in autoimmune encephalitis.

Methods

We performed a systematic literature search using MEDLINE, Embase, PubMed and PsychInfo databases. We selected studies that explored the correlation between early clinical and paraclinical findings, and patient outcomes. Data was extracted, analyzed and recorded in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines.

Results

Forty four publications detailing 2823 subjects matched our inclusion criteria. There was considerable heterogeneity in methodology, patient profile, investigation results and clinical outcome measures. Findings were often discrepant for cases of anti-NMDAR encephalitis when compared with other causes of autoimmune encephalitis. Delay in immunotherapy contributed to a variety of worse outcomes for patients with different subsets of autoimmune encephalitis. Altered consciousness, ICU admission and no use of immunotherapy were variables associated with poor prognosis in anti-NMDAR encephalitis. Older age, sex, the presence of status epilepticus, CSF abnormalities and MRI changes were unlikely to have significant prognostic value. The influence of antibody titers, autonomic dysfunction and underlying malignancy was unclear.

Conclusions

A number of variables were identified to have potential predictive value for outcomes in autoimmune encephalitis. Heterogeneous study design, size and quality were major limiting factors in this review.

https://ift.tt/2Awh6PB

Molecular mimicry and autoimmunity

Publication date: Available online 26 October 2018

Source: Journal of Autoimmunity

Author(s): Manuel Rojas, Paula Restrepo-Jiménez, Diana M. Monsalve, Yovana Pacheco, Yeny Acosta-Ampudia, Carolina Ramírez-Santana, Patrick S.C. Leung, Aftab A. Ansari, M. Eric Gershwin, Juan-Manuel Anaya

Abstract

Molecular mimicry is one of the leading mechanisms by which infectious or chemical agents may induce autoimmunity. It occurs when similarities between foreign and self-peptides favor an activation of autoreactive T or B cells by a foreign-derived antigen in a susceptible individual. However, molecular mimicry is unlikely to be the only underlying mechanism for autoimmune responses; other factors such as breach in central tolerance, non-specific bystander activation, or persistent antigenic stimuli (amongst others) may also contribute to the development of autoimmune diseases. Host genetics, exposure to microbiota and environmental chemicals are additional links to our understanding of molecular mimicry. Our current knowledge of the detailed mechanisms of molecular mimicry is limited by the issues of prolonged periods of latency before the appearance of disease, the lack of enough statistical power in epidemiological studies, the limitations of the potential role of genetics in human studies, the relevance of inbred murine models to the diverse human population and especially the limited technology to systematically dissect the human T-cell repertoire and B-cell responses. Nevertheless, studies on the role of autoreactive T-cells that are generated secondary to molecular mimicry, the diversity of the T-cell receptor repertoires of auto-reactive T-cells, the role of exposure to cryptic antigens, the generation of autoimmune B-cell responses, the interaction of microbiota and chemical adjuvants with the host immune systems all provide clues in advancing our understanding of the molecular mechanisms involved in the evolving concept of molecular mimicry and also may potentially aid in the prevention and treatment of autoimmune diseases.

https://ift.tt/2PXCFO9

Viral hepatitis, inflammation, and cancer: A lesson for autoimmunity

Publication date: Available online 26 October 2018

Source: Journal of Autoimmunity

Author(s): Silvia Piconese, Ilenia Cammarata, Vincenzo Barnaba

Abstract

In the present review, we analyzed the various overlapping and non-mutually exclusive mechanisms that intersect and form complex and highly flexible immunological networks allowing the defense against liver infections and tumors. Liver immunity results from the combination of the skills of systemic and local immune system(s) to sense and recognize pathogen or tumor antigens, to sensitize a wide range of innate and adaptive immune cells, and to clear the "invaders", through the establishment of a transient liver immunopathology state undergoing resolution/control of infections or tumors, and memory development. Then, a special emphasis is placed on discussing about the capacity of the immune system(s) to develop a state of chronic low-level immunopathology adapting through the intervention of simultaneous immunoregulatory mechanisms, when the liver is infected by highly mutable viruses (e.g., hepatitis B or C viruses [HBV or HCV]) capable to escape from the immune recognition. The establishment of chronic inflammation represents an advantage for the species survival, because it guarantees the long-term survival of human hosts despite the virus persistence. However, chronic inflammation, in the long run, can evolve towards severe consequences (decompensated cirrhosis and hepatocellular carcinoma) in some individuals, finding requiring the impelling need of discovering new therapeutic anti-viral and immunostimulatory agents addressed, in combination, to fight especially HBV that, in contrast to HCV, lacks antivirals capable to eradicate the virus. Finally, we discussed the concept proposing that the divergent immunoregulatory mechanisms that develop in persisting infections or tumors, on the one hand, and autoimmunity, on the other hand, are the mirror image of each other, whose understanding is also relevant for preparing novel immunotherapeutic approaches in autoimmune diseases.

https://ift.tt/2PZxKwa

Scholar : ΦΩΝΗ - νέα αποτελέσματα

[PDF] Η επίδραση της μουσικής στα άτομα με ειδικές ανάγκες

Σ ΠΕΡΔΙΚΗ - 2018

Page 1. ΤΕΧΝΟΛΟΓΙΚΟ ΕΚΠΑΙΔΕΥΤΙΚΟ ΙΔΡΥΜΑ ΔΥΤΙΚΗΣ ΕΛΛΑΔΑΣ ΣΧΟΛΗ
ΕΠΑΓΓΕΛΜΑΤΩΝ ΥΓΕΙΑΣ & ΠΡΟΝΟΙΑΣ ΤΜΗΜΑ ΝΟΣΗΛΕΥΤΙΚΗΣ ΠΤΥΧΙΑΚΗ ΕΡΓΑΣΙΑ
«Η ΕΠΙΔΡΑΣΗ ΤΗΣ ΜΟΥΣΙΚΗΣ ΣΤΑ ΑΤΟΜΑ ΜΕ ΕΙΔΙΚΕΣ ΑΝΑΓΚΕΣ» …

[PDF] Εφαρμογές της πληροφορικής σε άτομα με ειδικές ανάγκες

Χ Στύλιος - 2018

Page 1. AΕΙ ΠΕΙΡΑΙΑ TT ΣΧΟΛΗ ΤΕΧΝΟΛΟΓΙΚΩΝ ΕΦΑΡΜΟΓΩΝ ΤΜΗΜΑ ΜΗΧΑΝΙΚΩΝ
ΗΛΕΚΤΡΟΝΙΚΩΝ ΥΠΟΛΟΓΙΣΤΙΚΩΝ ΣΥΣΤΗΜΑΤΩΝ TE ΠΤΥΧΙΑΚΗ ΕΡΓΑΣΙΑ Εφαρμογές
της Πληροφορικής σε Άτομα με Ειδικές Δεξιότητες Στύλιος Χρήστος …

[PDF] Σχήμα λόγου και χιούμορ στα σενάρια του Αλέκου Σακελλάριου

Κ Αβραμίδου - 2018

Page 1. ΠΑΝΕΠΙΣΤΗΜΙΟ ΔΥΤΙΚΗΣ ΜΑΚΕΔΟΝΙΑΣ ΠΑΙΔΑΓΩΓΙΚΗ ΣΧΟΛΗ ΤΜΗΜΑ
ΝΗΠΙΑΓΩΓΩΝ Π.Μ.Σ.: ΕΠΙΣΤΗΜΕΣ ΤΗΣ ΑΓΩΓΗΣ ΚΑΤΕΥΘΥΝΣΗ: ΔΙΔΑΣΚΑΛΙΑ ΤΗΣ
ΝΕΑΣ ΕΛΛΗΝΙΚΗΣ ΓΛΩΣΣΑΣ Διπλωματική εργασία Σχήμα …

[PDF] Ασύρματη επικοινωνία πομπών Xbee μέσω Arduino

Ο Νοβίτσκι - 2018

Page 1. Ασύρματη επικοινωνία πομπών Xbee μέσω Arduino 1 ΟΛΈΞΙ Ο.
ΝΟΒΊΤΣΚΙ ΠΑΝΔΠΙ΢ΣΗΜΙΟ ΓΤΣΙΚΗ΢ ΑΣΣΙΚΗ΢ ΢ΥΟΛΗ ΜΗΥΑΝΙΚΧΝ ΣΜΗΜΑ
ΜΗΥΑΝΙΚΧΝ ΠΛΗΡΟΦΟΡΙΚΗ΢ ΚΑΙ ΤΠΟΛΟΓΙ΢ΣΧΝ ΠΣΤΥΙΑΚΗ ΔΡΓΑ΢ΙΑ …

[PDF] Χρήση ψηφιακών μέσων για την υποβοήθηση στην εκμάθηση της ταστιέρας της κιθάρας: το εκπαιδευτικό σύστημα "Fretfull"

Γ Ματσάγγος - 2018

Page 1. ΠΑΝΕΠΙΣΤΗΜΙΟ ΠΕΙΡΑΙΩΣ ΤΜΗΜΑ ΨΗΦΙΑΚΩΝ ΣΥΣΤΗΜΑΤΩΝ
ΠΡΟΓΡΑΜΜΑ ΜΕΤΑΠΤΥΧΙΑΚΩΝ ΣΠΟΥΔΩΝ "ΗΛΕΚΤΡΟΝΙΚΗ ΜΑΘΗΣΗ"
ΧΡΗΣΗ ΨΗΦΙΑΚΩΝ ΜΕΣΩΝ ΓΙΑ ΤΗΝ ΥΠΟΒΟΗΘΗΣΗ ΣΤΗΝ ΕΚΜΑΘΗΣΗ …

[PDF] Σχιζοφρένεια και νοσηλευτικές παρεμβάσεις

Ε ΒΑΡΒΙΑ - 2018

Page 1. ΤΕΧΝΟΛΟΓΙΚΟ ΕΚΠΑΙΔΕΥΤΙΚΟ ΙΔΡΥΜΑ ΔΥΤΙΚΗΣ ΕΛΛΑΔΑΣ ΣΧΟΛΗ
ΕΠΑΓΓΕΛΜΑΤΩΝ ΥΓΕΙΑΣ ΚΑΙ ΠΡΟΝΟΙΑΣ ΤΜΗΜΑ ΝΟΣΗΛΕΥΤΙΚΗΣ ΠΤΥΧΙΑΚΗ
ΕΡΓΑΣΙΑ ΣΧΙΖΟΦΡΕΝΕΙΑ ΚΑΙ ΝΟΣΗΛΕΥΤΙΚΕΣ ΠΑΡΕΜΒΑΣΕΙΣ …

[PDF] Ασύρματος έλεγχος του οχήματος 3-in-1 all terrain robot OWI 536 μέσω Arduino και εφαρμογής android-υλοποίηση εκπαιδευτικών ασκήσεων

Π Γραμματικός - 2018

Page 1. ΠΑΝΕΠΙΣΤΗΜΙΟ ΔΥΤΙΚΗΣ ΑΤΤΙΚΗΣ ΣΧΟΛΗ ΜΗΧΑΝΙΚΩΝ ΤΜΗΜΑ
ΜΗΧΑΝΙΚΩΝ ΠΛΗΡΟΦΟΡΙΚΗΣ ΚΑΙ ΥΠΟΛΟΓΙΣΤΩΝ ΠΤΥΧΙΑΚΗ ΕΡΓΑΣΙΑ Ασύρματος
έλεγχος του οχήματος 3-in-1 all terrain robot OWI 536 μέσω Arduino …

Empire and Gender in LXX Esther

MJ Stone - 2018

 

Δημιουργία λίστας των ειδοποιήσεών μου

Ακύρωση ειδοποίησης

Αυτή η ειδοποίηση αποστέλλεται από τον Μελετητή Google. Ο Μελετητής Google είναι μια υπηρεσία που παρέχεται από την Google.

Scholar : Undersea "Hyperbaric Medicine" - νέα αποτελέσματα

[HTML] Alternative formats

HB Cobanoglu, E Vuralkan, A Arslan, B Mirasoglu…

… 1 Department of Otorhinolaryngology, Karadeniz Technical University Faculty of
Medicine, Trabzon, Turkey. 2 Department of Underwater and Hyperbaric Medicine,
Meram University, Faculty of Medicine, Konya, Turkey. 3 Department …

 

Δημιουργία λίστας των ειδοποιήσεών μου

Ακύρωση ειδοποίησης

Αυτή η ειδοποίηση αποστέλλεται από τον Μελετητή Google. Ο Μελετητής Google είναι μια υπηρεσία που παρέχεται από την Google.

Scholar : ΒΑΣΗ ΚΡΑΝΙΟΥ - νέα αποτελέσματα

[PDF] Νοσηλευτική παρέμβαση πολυτραυματία ασθενή στη μονάδα εντατικής θεραπείας

Γ ΠΑΣΣΙΑ - 2018

… υπεύθυνοι για την εφαρμογή της πλήρους θεραπευτικής αντιμετώπισης του ασθενούς
σε εικοσιτετράωρη βάση, την παρακολούθηση της εξέλιξης της υγείας των ασθενών, την
οργάνωση του τμήματος όσον αφορά στην εισαγωγή και εξαγωγή τους (Γρηγοράκος,2014) …

[PDF] Θεραπεία, υποστήριξη και παρακολούθηση πολυτραυματία ασθενή στη ΜΕΘ

Ε ΓΕΩΡΓΑΚΟΠΟΥΛΟΥ - 2018

… Ένα ανοικτό τραύμα στο κεφάλι σημαίνει ότι ένα αντικείμενο χτύπησε το κεφάλι, έσπασε
το κρανίο και εισήλθε στον εγκέφαλο … Πληγές στο τριχωτό της κεφαλής § Κατάγματα κρανίου …
Αρχίζει από τη στιγμή του τραυματισμού και αποτελεί τη βάση της επουλώσεως …

[PDF] Νοσηλευτική διαχείριση κρίσεων και επειγουσών καταστάσεων

Σ ΒΑΣΙΛΑΚΗ, ΖΩΗ ΤΖΙΡΩΝΗ - 2018

… οποίες υπερβαίνουν την ικανότητα της πληγείσας κοινότητας ή κοινωνίας να τις
αντιμετωπίσει με βάση μόνο τις δικές της δυνάμεις και μέσα … περιθάλψουν με βάση τα
διαθέσιμα μέσα και χρειάζονται πρόσθετη και ορισμένες φορές εξωτερική βοήθεια …

[PDF] Χρήση ψηφιακών μέσων για την υποβοήθηση στην εκμάθηση της ταστιέρας της κιθάρας: το εκπαιδευτικό σύστημα "Fretfull"

Γ Ματσάγγος - 2018

… Η εξέλιξη των μουσικών ασκήσεων σε πραγματικές συνθήκες (μελέτη βάση
μουσικών έργων), • Η στήριξη της μεθóδου σε γνώσεις που οι μαθητές
κατέχουν (λαμβάνοντας υπóψη το επίπεδο των μαθητών) … νερó, τα χημικά …

 

Δημιουργία λίστας των ειδοποιήσεών μου

Ακύρωση ειδοποίησης

Αυτή η ειδοποίηση αποστέλλεται από τον Μελετητή Google. Ο Μελετητής Google είναι μια υπηρεσία που παρέχεται από την Google.

Scholar : intitle:laryngeal - new results

Vocal Cord Palsies Missed by Transcutaneous Laryngeal Ultrasound (TLUSG): Do They Experience Worse Outcomes?

KP Wong, KP Au, S Lam, YK Chang, BHH Lang - World Journal of Surgery, 2018

Introduction Transcutaneous laryngeal ultrasound (TLUSG) is an innovative, non-
invasive tool in detecting post-thyroidectomy vocal cord palsy (VCP). However,
TLUSG failed to detect about 6–15% laryngoscopic examination (LE)-confirmed …

Gastroesophageal and Laryngopharyngeal Reflux Associated with Laryngeal Malignancy: A Systematic Review and Meta-Analysis

SM Parsel, EL Wu, CA Riley, ED McCoul - Clinical Gastroenterology and Hepatology, 2018

Background & Aims Gastric reflux could lead to chronic mucosal inflammation and
contribute to development of laryngeal malignancies, although there is controversy
over this association. We performed a systematic review and meta-analysis to assess …

Dilated Minute Chambers in Laryngeal Vocal Fold Polyps: Histopathological and Ultrastructural Features

N Comunoglu, I Kocak, HI Saygi, HM Yener, S Batur… - Journal of Voice, 2018

In Reinke's space of human vocal fold, type III collagen forms a three dimensional
network and this contains numerous minute chambers in between these fibers.
These compartments are occupied by glycosaminoglycans and glycoproteins. In …

[HTML] The evolution and progress of studies of the anatomy & electrophysiology of the laryngeal nerves in thyroid surgery

B Wojtczak, M Barczyński - Annals of Thyroid, 2018

Thyroid surgery has always been closely involved with the recurrent laryngeal nerve
(RLN) and the external branch of the superior laryngeal nerve (EBSLN). The goal of
thyroid surgery is to remove all pathological thyroid tissue while preserving the …

Clinical performance of airway management with the i-gel and laryngeal mask airway supreme in geriatric patients: a prospective and randomized study.

CB In, SA Cho, SJ Lee, TY Sung, CK Cho - Korean journal of anesthesiology, 2018

Background: Geriatric patients are susceptible to respiratory and hemodynamic
adverse events during endotracheal intubation and extubation due to anatomic and
physiological changes with aging. Supraglottic airway devices (SADs) provide …

[PDF] Consequences of Misdiagnosed and Mismanaged Hereditary Angioedema Laryngeal Attacks: An Overview of Cases from the Romanian Registry

D Moldovan, N Bara, V Nădășan, G Gábos, E Mihály - Case Reports in Emergency …, 2018

Emergency department (ED) physicians frequently encounter patients presenting
with angioedema. Most of these involve histamine-mediated angioedema; however,
less common forms of angioedema (bradykinin-mediated) also occur. It is vital …

Laryngeal stroboscopy‐normative values for amplitude, open quotient, asymmetry and phase difference in young adults

EM Sielska‐Badurek, K Jędra, M Sobol… - Clinical Otolaryngology

Objective To provide the normative values for laryngeal stroboscopy (LS) concerning
amplitude, open quotient, asymmetry and phase difference in healthy, young
subjects. Study design Prospective case‐control study. Setting Patients treated at a …

 

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Scholar : Πλαστική Χειρουργική - νέα αποτελέσματα

[PDF] Μελέτη εφαρμογής διασυνοριακών υπηρεσιών ηλεκτρονικής υγείας στην Κύπρο προς διευκόλυνση της διασυνοριακής υγειονομικής περίθαλψης και προώθηση του …

Μ Αντωνίου - 2018

Page 1. Ανοικτό Πανεπιστήμιο Κύπρου Σχολή Θετικών και Εφαρμοσμένων Επιστημών
Μεταπτυχιακό Πρόγραμμα Σπουδών Εφαρμοσμένη Πληροφορική της Υγείας & Τηλεϊατρική
Μεταπτυχιακή Διατριβή Μελέτη Εφαρμογής Διασυνοριακών Υπηρεσιών …

[PDF] Πεποιθήσεις των γυναικών για τον καρκίνο του τραχήλου της μήτρας και την εξέταση τραχηλικού επιχρίσματος (Τεστ Παπανικολάου)

Χ ΓΙΑΝΝΟΠΟΥΛΟΥ - 2018

Page 1. ΤΕΧΝΟΛΟΓΙΚΟ ΕΚΠΑΙΔΕΥΤΙΚΟ ΙΔΡΥΜΑ ΔΥΤΙΚΗΣ ΕΛΛΑΔΑΣ
ΣΧΟΛΗ ΕΠΑΓΓΕΛΜΑΤΩΝ ΥΓΕΙΑΣ ΚΑΙ ΠΡΟΝΟΙΑΣ (ΣΕΥΠ) ΤΜΗΜΑ
ΝΟΣΗΛΕΥΤΙΚΗΣ ΠΤΥΧΙΑΚΗ ΕΡΓΑΣΙΑ " Πεποιθήσεις των γυναικών για …

 

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Scholar : Obstructive sleep apnea - νέα αποτελέσματα

Obstructive sleep apnea syndrome should always be screened in patients complaining of nocturia

V Misraï, H Charbonneau, D Attias, A Pathak - World Journal of Urology, 2018

We read with interest the manuscript entitled "Diagnosis and management of
nocturia in current clinical practice: who are nocturia patients, and how do we treat
them?" recently published in the World Journal of Urology [1]. Drangsholt et al. aimed …

Sleep Study and Oximetry Parameters for Predicting Postoperative Complications in Patients with Obstructive Sleep Apnea

C Suen, CM Ryan, T Mubashir, N Ayas, L Abrahamyan… - Chest, 2018

Background In the surgical setting, obstructive sleep apnea (OSA) is associated with
an increased risk of postoperative complications. At present, risk stratification using
OSA-associated parameters derived from polysomnography (PSG) or overnight …

… Positive Airway Pressure Use and Nasal Saline Rinses After Endonasal Endoscopic Skull Base Surgery in Patients With Obstructive Sleep Apnea: A Practice Pattern …

DL Choi, K Reddy, EK Weitzel, BW Rotenberg… - American journal of …, 2018

Background Endoscopic skull base surgery continues to evolve in its indications,
techniques, instrumentation, and postoperative care. As surgery of the skull base will
often violate dura, intraoperative and postoperative cerebrospinal fluid (CSF) leak is …

Relationship of evening meal with sleep quality in obese individuals with obstructive sleep apnea

CM de Melo, MP del Re, MVL dos Santos Quaresma… - Clinical Nutrition ESPEN, 2018

Purpose To determine the relationship between habitual food intake, resting energy
expenditure and sleep pattern in obstructive sleep apnea (OSA) patients. Methods
Forty-five OSA obese males were included in the study. All participants were …

Transoral robotic surgery of the tongue base for obstructive sleep apnea: Preliminary results

G de Bonnecaze, B Vairel, A Dupret-Bories, E Serrano… - European Annals of …, 2018

Introduction Obstructive sleep apnea syndrome (OSAS) is a major public health
issue. Robotic tongue-base reduction surgery is being developed, but needs
assessment. The present study reports clinical and polygraphic results at 6 months' …

Association between diet quality and sleep apnea in the Multi-Ethnic Study of Atherosclerosis

M Reid, JE Maras, S Shea, AC Wood, C Castro-Diehl… - Sleep, 2018

… In particular, obstructive sleep apnea (OSA), a condition characterized by
intermittent upper airway obstruction [18], causes sleep fragmentation as
well as exposure to intermittent … Prior studies have shown associations …

Efficacy of a mandibular advancement intraoral appliance (MOA) for the treatment of obstructive sleep apnea syndrome (OSAS) in pediatric patients: A pilot-study.

G Modesti-Vedolin, C Chies, S Chaves-Fagondes… - Medicina oral, patologia oral …, 2018

BACKGROUND: To evaluate the treatment efficacy of a mandibular advancement
intraoral appliance (MOA) for treatment of obstructive sleep apnea syndrome (OSAS)
in pediatric patients. MATERIAL AND METHODS: Eighteen patients (mean= 8.39 …

Comparison Oxidative Stress Effects on Enzymatic and Non-enzymatic Indices in Patients with Mild and Severe Obstructive Sleep Apnea

P Hanachi, Z Ghaseminya, K Sadeghniyat, A Golestani - Journal of Payavard …, 2018

Materials and Methods: The 35 subjects of OSA were selected and categorized
according to the apnea-hypopnea index (AHI) in two groups: Mild OSA (n= 17) and
severe OSA (n= 18). The fasting blood samples were taken in order to evaluate the …

Chronic disease management: Obstructive sleep apnoea

B Saini - Australian Pharmacist, 2018

… Soft palate Obstruction Uvula Epiglottis … to monitor and follow-up sleep/wake
patterns in individuals attending community pharmacy with sleeping disorders …
Shoukry G, Wong K, Bartlett D, Saini B. Treatment experience of people with …

[PDF] Associations between Sleep-Disordered Breathing and Metabolic Risk Factors beyond Obesity

Y Wakabayashi, R Oka, M Nakaya, S Karashima… - Journal of Diabetes …, 2018

… to take a sleep study to employees with sleep-related symptoms of obstructive
sleep apnea including loud … was defined as the average number of apneic
plus hypopneic episodes per hour of sleep. Apnea was defined as a complete …

 

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