Radioiodine

Editorial Radioiodine: 80 years and counting; the past, present, and future by Matthew D Ringel Thematic Review Radioiodine treatment: an historical and future perspective by Patricia Borges de Souza and Christopher John McCabe Tailoring the approach to radioactive iodine treatment in thyroid cancer by Sarah E Mayson, Christine M Chan, and Bryan R Haugen The complex regulation of NIS expression and activity in thyroid and extrathyroidal tissues by Garcilaso Riesco-Eizaguirre, Pilar Santisteban, and Antonio De la Vieja Na+/I− symporter expression, function, and regulation in non-thyroidal tissues and impact on thyroid cancer therapy by Sissy M Jhiang and Jennifer A Sipos Redifferentiation-facilitated radioiodine therapy in thyroid cancer by Livia Lamartina et al. The sodium iodide symporter (NIS): novel applications for radionuclide imaging and treatment by C Spitzweg et al. Research Development of improved SRC-3 inhibitors as breast cancer therapeutic agents by Li Qin et al. Targeted genomic analysis of 364 adrenocortical carcinomas by Nikita Pozdeyev et al. Antitumor immune response is associated with favorable survival in GEP-NEN G3 by Vivian Rosery et al.

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Resveratrol protects against inorganic arsenic-induced oxidative damage and cytoarchitectural alterations in female mouse hippocampus

xlomafota13 shared this article with you from Inoreader Resveratrol protects against inorganic arsenic-induced oxidative damage and cytoarchitectural alterations in female mouse hippocampus Via histochem Acta Histochem. 2021 Oct 8;123(7):151792. doi: 10.1016/j.acthis.2021.151792. Online ahead of print. ABSTRACT Prolonged inorganic arsenic (iAs) exposure is widely associated with brain damage particularly in the hippocampus via oxidative and apoptotic pathways. Resveratrol (RES) has gained considerable attention because of its benefits to human health. However, its neuroprotective potential against iAs-induced toxicity in CA1 region of hippocampus remains unexplored. Therefor e, we investigated the neuroprotective efficacy of RES against arsenic trioxide (As2O3)-induced adverse effects on neuronal morphology, apoptotic markers and oxidative stress parameters in mouse CA1 region (hippocampus). Adult female Swiss albino mice of reproductive maturity were orally exposed to either As2O3 (2 and 4 mg/kg bw) alone or in combination with RES (40 mg/kg bw) for a period of 45 days. After animal sacrifice on day 46, the perfusion fixed brain samples were used for the observation of neuronal morphology and studying the morphometric features. While the freshly dissected hippocampi were processed for biochemical estimation of oxidative stress markers and western blotting of apoptosis-associated proteins. Chronic iAs exposure led to significant decrease in Stratum Pyramidale layer thickness along with reduction in cell density and area of Pyramidal neurons in contrast to the controls. Biochemical analysis showed reduced hippo campal GSH content but no change in total nitrite (NO) levels following iAs exposure. Western blotting showed apparent changes in the expression levels of Bax and Bcl-2 proteins following iAs exposure, however the change was statistically insignificant. Contrastingly, iAs +RES co-treatment exhibited substantial reversal in morphological and biochemical observations. Together, these findings provide preliminary evidence of neuroprotective role of RES on structural and biochemical alterations pertaining to mouse hippocampus following chronic iAs exposure. PMID:34634674 | DOI:10.1016/j.acthis.2021.151792 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Necrotising Myositis - Learnings for a Plastic Surgeon

xlomafota13 shared this article with you from Inoreader Necrotising Myositis - Learnings for a Plastic Surgeon Via Journal of plastic, reconstructive & aesthetic surgery : JPRAS J Plast Reconstr Aesthet Surg. 2021 Sep 20:S1748-6815(21)00434-4. doi: 10.1016/j.bjps.2021.08.046. Online ahead of print. ABSTRACT BACKGROUND: Necrotising myositis (NM) is a life-threatening emergency. Prompt treatment is associated with more favourable outcomes, but early diagnosis is challenging. The initial absence of cutaneous signs and symptoms coupled with delayed recognition commonly result in higher rates of morbidity and mortality. OBJECTIVES: Analyse data regarding demographics, epidemiology, aetiology, clinical manifestations, diagnosis and treatment of previously reported cases. This publication is intended for plastic surgeons in training to help them look out for this disease. SEARCH METHODS/CRITERIA: Publications reporting necrotising myositis between 1974 to January 2020 were identified from Embase, Medline All, Web of Science Core Collection, Google Scholar and Cochrane Central Register of Controlled Trial. DATA COLLECTION AND ANALYSIS: Identified studies were exported to an end note library. In animal studies, studies relating to statin-induced myotoxicity and auto-immune myositis were excluded. The quality of included case reports was assessed using JBI Critical Appraisal Checklist for Case Reports. MAIN RESULTS: The most common initial presentation was a few days of antecedent prodromal flu-like symptoms associated with muscle pain. The mean age was 43.3 years and 82% had no significant medical history. The most frequent misdiagnoses were muscle strain (11%), deep vein thrombosis (10%) and viral illness (9%). Seventy-four per cent of presentations were due to Group A Streptococcus infections and only 3.5% of cases were polymicrobial. The most common clinical course following the initial presentation was rapid deterioration into profound sepsis and progression into multi-organ failure. The overall mortality rate was 36.5%. CONCLUSIONS: NM is a life-threatening musc le infection. It is a diagnostic conundrum as initial presentation is often only myalgia without features of preceding trauma. We propose that a high index of suspicion and increased awareness will reduce morbidity. OTHER: PROSPERO (registration number CRD42018087060). Nil funding/conflict of interest. PMID:34635455 | DOI:10.1016/j.bjps.2021.08.046 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

A silent, trapped guest in the maxillary sinus: Oestrus ovis myiasis with unusual presentation (with CARE guideline)

xlomafota13 shared this article with you from Inoreader A silent, trapped guest in the maxillary sinus: Oestrus ovis myiasis with unusual presentation (with CARE guideline) Via European Annals of Otorhinolaryngology, Head and Neck Diseases Publication date: Available online 11 October 2021 Source: European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): A. İşlek, S. Şimşek View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Migrated Foreign Body of Upper Digestive Tract—A Ten-Year Institutional Experience

xlomafota13 shared this article with you from Inoreader Migrated Foreign Body of Upper Digestive Tract—A Ten-Year Institutional Experience Via Otolaryngology Indian Abstract The ingested foreign body is one of the commonest emergencies encountered by otolaryngologists Depending on the shape and duration of impaction, a small number of foreign bodies (1–2%) can perforate the wall of the gastrointestinal Tract. A migrated foreign body may remain quiescent or cause life-threatening suppurative and vascular complications. Data were collected retrospectively from the hospital records in a tertiary care hospital in South India from 2010 to 2020. Fifteen patients diagnosed with migrated foreign body and who underwent neck exploration were included in the study. Demographic details, mode of presentation, clinical and radiological findings, rigid esophagoscopy findings, neck exploration techniques employed were noted. The mean age of the patients was 37.66 years. All patients had a history of dysphagia, odynophagia, and point tenderness. All the patients underwent a lateral neck radiograph, and it was positive in 12 patients (80%), whi le in 3 patients (20%), it was negative. All the patients had a positive finding in Contrast-Enhanced Computed Tomography. Esophagoscopy was done prior to neck exploration to identify the site of injury and the probable site of migration. All the patients underwent lateral neck exploration, and foreign body was removed. Migrated foreign body can cause significant morbidity and mortality if not diagnosed and managed early. Strong suspicion and a systematic approach are needed for the diagnosis and management. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

An Unusual Tumor in an Uncommon Site-Orbital Rosai–Dorfman Disease: A Case Report

xlomafota13 shared this article with you from Inoreader An Unusual Tumor in an Uncommon Site-Orbital Rosai–Dorfman Disease: A Case Report Via Otolaryngology Indian Abstract Rosai–Dorfman disease (RDD) is also known as Sinus Histiocytosis with Massive Lymphadenopathy. It is a rare, benign, self-limiting disease of phagocytic histiocytes presenting with massive painless cervical lymphadenopathy. RDD can present as a nodal disease and also extra-nodal involvement with episodes of exacerbation and remissions and relapses after treatment. Its etiology remains poorly understood and is highly variable in its clinical presentation and response to treatment. Its treatment is poorly defined but the prognosis is usually fair. Here we are reporting a rare, unusual clinical presentation of infraorbital soft tissue mass diagnosed as RDD with cyto-histopathological correlation. Only a few such cases have been reported in the literature. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Sentinel Lymph Node Biopsy Versus Elective Node Dissection in Stage cT1‐2N0 Oral Cavity Cancer

xlomafota13 shared this article with you from Inoreader Sentinel Lymph Node Biopsy Versus Elective Node Dissection in Stage cT1‐2N0 Oral Cavity Cancer Via The Laryngoscope Objective To compare overall survival (OS) and disease-free survival (DFS) between sentinel lymph node biopsy (SNB) and elective neck dissection (END) in the surgical management of cT1-2N0 oral cavity squamous cell carcinoma (OCSCC). Methods English full-text articles were searched in PubMed and Embase on May 9, 2021. Articles had to compare SNB with END in cT1-T2N0 OCSCC patients; report hazard ratios (HRs), Kaplan–Meier curves, or P-values with total number of events for survival outcomes; be from a clinical trial, cohort, or case–control study. Two reviewers reviewed articles and a third settled disagreements. Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and the Risk of Bias in Non-randomized Studies of Interventions tool and revised Cochrane risk-of-bias tool for randomized trials were used. The generic inverse variance method with a random-effect model was used for meta-analysis. Results Ten studies, five retrospective, three prospective, and two randomized controlled trials, were included (total number of patients [n] = 10,498, END n = 9102, SNB n = 1396). No significant differences were found in OS (HR = 0.92; 95% confidence interval [CI]: 0.65–1.31) or DFS (HR = 0.70; 95% CI: 0.41–1.20). Heterogeneity was not detected in pooled OS analysis (P = .18; I 2 = 30%), but was in pooled DFS analysis (P = .003; I 2 = 66%). Conclusions No statistically significant differences in OS or DFS were observed between SNB and END in cT1-2N0 OCSCC, suggesting that SNB might be an alternative to END in the management of early-stage, clinically node-negative OCSCC. Laryngoscope, 2021 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

miR‐29a‐3p promotes migration and invasion in ameloblastoma via Wnt/β‐catenin signaling by targeting catenin beta interacting protein 1

xlomafota13 shared this article with you from Inoreader miR‐29a‐3p promotes migration and invasion in ameloblastoma via Wnt/β‐catenin signaling by targeting catenin beta interacting protein 1 Via Head & Neck Abstract Background Ameloblastoma (AB) is a common epithelial odontogenic tumor. The Wnt/β-catenin pathway has been found to be related to AB invasion. Methods The alteration expression of microRNAs (miRNAs) and messenger RNAs (mRNAs) was performed by miRNA and mRNA microarray analysis and validated by quantitative real-time polymerase chain reaction (RT-PCR). The effects of miR-29a-3p on migration and invasion in AB cells were evaluated by a transwell assay. Bioinformatic prediction was conducted using the miRSystem and validated by quantitative RT-PCR, western blot, and a luciferase reporter assay. Results miR-29a-3p was overexpressed in AB tissues, which promoted the migration and invasion of AB cells in vitro. Catenin beta interacting protein 1 (CTNNBIP1), a negative regulator of the Wnt/β-catenin pathway, was predicted to be a target of miR-29a-3p. miR-29a-3p inhibited the expression of CTNNBIP1 and promoted the expression of the downstream molecules of the Wnt/β-catenin pathway. Conclusions miR-29a-3p promoted migration and invasion in AB via Wnt/β-catenin signaling by targeting CTNNBIP1. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.