Quantitative FLAIR MRI in Amyotrophic Lateral Sclerosis

Publication date: Available online 29 May 2017
Source:Academic Radiology
Author(s): Jeremy Fabes, Lucy Matthews, Nicola Filippini, Kevin Talbot, Mark Jenkinson, Martin R. Turner
Rationale and ObjectivesT2-weighted magnetic resonance imaging (MRI) hyperintensity assessed visually in the corticospinal tract (CST) lacks sensitivity for a diagnosis of amyotrophic lateral sclerosis (ALS). We sought to explore a quantitative approach to fluid-attenuated inversion recovery (FLAIR) MRI intensity across a range of ALS phenotypes.Materials and MethodsThirty-three classical ALS patients, 10 with a flail arm presentation, and six with primary lateral sclerosis underwent MRI at 3 Tesla. Comparisons of quantitative FLAIR intensity in the CST and corpus callosum were made between 21 healthy controls and within patient phenotypic subgroups, some of whom were studied longitudinally.ResultsMean FLAIR intensity was greater in patient groups. The cerebral peduncle intensity provided the strongest subgroup classification. FLAIR intensity increased longitudinally. The rate of change of FLAIR within CST correlated with rate of decline in executive function and ALS functional rating score.ConclusionsFLAIR MRI encodes quantifiable information of potential diagnostic, stratification, and monitoring value.



http://ift.tt/2rzzYdl

Zinc oxide nanoparticle energy band gap reduction triggers the oxidative stress resulting into autophagy-mediated apoptotic cell death

Publication date: September 2017
Source:Free Radical Biology and Medicine, Volume 110
Author(s): Manoranjan Arakha, Jyoti Roy, Parth Sarthi Nayak, Bibekanand Mallick, Suman Jha
The physico-chemical properties of nanoparticle (NP), such as particle size, surface defects, crystallinity and accessible surface, affect NP photocatalytic activity that in turn defines the NP cytotoxic propensity. Since zinc oxide nanoparticle (ZnONP) energy band gap falls in a range of a semiconductor, the particle possesses photocatalytic activity. Hence, the study correlates energy band gap with cytotoxic propensity of ZnONP. To this end, ZnONPs with varying energy band gap are fabricated by varying calcination temperature. Cytotoxic propensity of the fabricated ZnONPs against HT1080 cell indicates that the particle with least energy band gap shows highest cytotoxicity. The data also indicate that the cytotoxicity is triggered primarily through reactive oxygen species (ROS)-mediated pathway. Additionally, the comet assay and γH2AX activity assay reveal that decreasing energy band gap of the particle increases DNA damaging propensity. Furthermore, cell cycle analysis indicates that the cell treatment with decreasing energy band gap ZnONP results in significant increase in cell population fraction in subG1 phase. Whereas, acridine orange binding assay and increased expression level of LC3II indicate that the cell tries to recover the stress by scavenging damaged cellular biomolecules and ROS using autophagosomes. Nevertheless, cell with the non-recoverable damages led into apoptotic cell death, as confirmed by Annexin V apoptosis assay, DNA fragmentation assay and 4,6-Diamidino-2-phenylindole dihydrochloride (DAPI) staining.

Graphical abstract

http://ift.tt/2qu4vJs

Mesna (2-mercaptoethane sodium sulfonate) functions as a regulator of myeloperoxidase

Publication date: September 2017
Source:Free Radical Biology and Medicine, Volume 110
Author(s): Roohi Jeelani, Seyedehameneh Jahanbakhsh, Hamid-Reza Kohan-Ghadr, Mili Thakur, Sana Khan, Sarah R. Aldhaheri, Zhe Yang, Peter Andreana, Robert Morris, Husam M. Abu-Soud
Myeloperoxidase (MPO), an abundant protein in neutrophils, monocytes, and macrophages, is thought to play a critical role in the pathogenesis of various disorders ranging from cardiovascular diseases to cancer. We show that mesna (2-mercaptoethanesulfonic acid sodium salt), a detoxifying agent, which inhibits side effects of oxazaphosphorine chemotherapy, functions as a potent inhibitor of MPO; modulating its catalytic activity and function. Using rapid kinetic methods, we examined the interactions of mesna with MPO compounds I and II and ferric forms in the presence and absence of chloride (Cl^-), the preferred substrate of MPO. Our results suggest that low mesna concentrations dramatically influenced the build-up, duration, and decay of steady-state levels of Compound I and Compound II, which is the rate-limiting intermediate in the classic peroxidase cycle. Whereas, higher mesna concentrations facilitate the porphyrin-to-adjacent amino acid electron transfer allowing the formation of an unstable transient intermediate, Compound I*, that displays a characteristic spectrum similar to Compound I. In the absence of plasma level of chloride, mesna not only accelerated the formation and decay of Compound II but also reduced its stability in a dose depend manner. Mesna competes with Cl^-, inhibiting MPO's chlorinating activity with an IC50 of 5µM, and switches the reaction from a 2e^- to a 1e^- pathway allowing the enzyme to function only with catalase-like activity. A kinetic model which shows the dual regulation through which mesna interacts with MPO and regulates its downstream inflammatory pathways is presented further validating the repurposing of mesna as an anti-inflammatory drug.

Graphical abstract

http://ift.tt/2quxpsG

Giant cell tumor in the sphenoid sinus and ethmoid sinus during childhood, and it is thought that optic atrophy was caused by compressive optic neuropathy.

http://orlhealth.blogspot.com/2017/05/giant-cell-tumor-in-sphenoid-sinus-and.html

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182

6948891480

alsfakia@gmail.com

Determination of the protein expression profiles of Propsilocerus akamusi (Tokunaga) Malpighian tubules response to cadmium stress by iTRAQ coupled LC–MS/MS

Publication date: Available online 29 May 2017
Source:Journal of Proteomics
Author(s): Xianyun Zheng, Zhiying Xie, Shu Wang, Pipeng Lin
Propsilocerus akamusi (Tokunaga) is an important prey species for fish and aquatic birds, which represent an important link in the aquatic food chain as other species of Chironomidae. Malpighian tubules (MT) play an important role in metabolism and detoxification of harmful compounds and metal accumulation. Our previous studies have reported that P. akamusi have an extraordinary resistance to Cd. In this paper, iTRAQ-based proteomics technology was first used to study the differential proteomics of MT of Propsilocerus akamusi under sublethal Cd stress for different time courses. 118 differential expressed proteins (DEPs) were identified through LC–MS/MS and further classified into 26 GO functional groups. Our results showed that metabolic process was the main biological functional categories. Cluster of orthologous groups of proteins (COG) analysis was also performed based on the number of unique proteins identified in each functional category, 22 metabolism-related DEPs were identified. P. akamusi adapted to Cd stress mainly by inducing the processes of lipid metabolism of MT and lipid may play a possible protection role in cadmium resistance in MT. The results provide important information for research on molecular mechanisms of Cd-stress adaption in Malpighian tubules of P. akamusi.Biological significancePropsilocerus akamusi (old species name: Tokunagayusurika akamusi) is an important prey species for fish and aquatic birds, which represent an important link in the aquatic food web as other species of Chironomidae. Malpighian tubules constitute a versatile organ which is able to exert excretory of chemical compounds, acting in the insect metabolism and detoxification of harmful compounds and metal accumulation. Our previous studies have reported that P. akamusi have an extraordinary resistance to Cd. However, up to now, there has been a lack of research on the molecular mechanisms of adaption to Cd stress in the Malpighian tubules of this species. Study on the adaptive mechanisms to Cd stress in Malpighian tubules of Propsilocerus akamusi through comparative proteome analysis is one important way to solve this problem. The aim of the present study was to understand the molecular mechanisms of adaption of the Malpighian tubules of P. akamusi exposed to Cd stress and assess the high expression of proteins involved in cellular adaptation to Cd stress. This will provide information about how this organ is responding to disturbances of contaminated ecosystems.

Graphical abstract

http://ift.tt/2qAJDLI

Proteomic fingerprinting of mistletoe (Viscum album L.) via combinatorial peptide ligand libraries and mass spectrometry analysis

Publication date: Available online 29 May 2017
Source:Journal of Proteomics
Author(s): María Vergara-Barberán, María Jesús Lerma-García, Maria Nicoletti, Ernesto Francisco Simó-Alfonso, José Manuel Herrero-Martínez, Elisa Fasoli, Pier Giorgio Righetti
Combinatorial peptide ligand libraries (CPLLs), coupled to mass spectrometry (MS) analysis, have been used to investigate in depth the proteome of Viscum album L. (VA), commonly named European mistletoe, in order to provide a first proteomic fingerprinting. For this purpose, the proteins were captured via CPLLs at two different pH values (acidic and neutral). A total of 648 non-redundant proteins were identified by using two different databases. The two pH values, chosen for bead incubations, have contributed to increment the capture ability: 56% and 31% of CPLLs species were respectively recognized at pH7.2 and at pH2.2. Finally the biological function of identified proteins was evaluated in order to understand their role on human health and the potential benefits of mistletoe extracts in medicine.SignificanceViscum album L. (VA) extracts are recently used as supporting medicine for cancer therapy, improving patients' survival and increasing their quality of life in medicine. These anticancer effects are investigated and they are probably due to mistletoe's capability to favor tumor cell's death and to modulate the immune system. Although the increasing interest in VA medical benefits, the role of its components in human health remains unclear. In order to exploit this aspect, it is important to comprehensively study proteins present in Viscum album L. (VA) extracts. Nevertheless, since plant proteomics analysis is in most cases handicapped by the presence of high-abundance proteins masking the detection of the low-abundance ones, it is important to overcome this challenge. In this sense, combinatorial peptide ligand libraries (CPLLs) have been used to reduce the dynamic protein concentration range to enable the identification of a higher amount of proteins than employing conventional methods. In this work, a total of 648 non-redundant proteins were identified: 56% and 31% of CPLLs species were respectively recognized at pH7.2 and at pH2.2. This deep proteome identification was useful to investigate the biological functions of proteins in order to evaluate their potential role in human health.

Graphical abstract

http://ift.tt/2qBkYXm

Quantitative assessment of wound healing using high-frequency ultrasound image analysis

Purpose

We aimed to develop a method for quantitative assessment of wound healing in ulcerated diabetic feet.

Methods

High-frequency ultrasound (HFU) images of 30 wounds were acquired in a controlled environment on post-debridement days 7, 14, 21, and 28. Meaningful features portraying changes in structure and intensity of echoes during healing were extracted from the images, their relevance and discriminatory power being verified by analysis of variance. Relative analysis of tissue healing was conducted by developing a features-based healing function, optimised using the pattern-search method. Its performance was investigated through leave-one-out cross-validation technique and reconfirmed using principal component analysis.

Results

The constructed healing function could depict tissue changes during healing with 87.8% accuracy. The first principal component derived from the extracted features demonstrated similar pattern to the constructed healing function, accounting for 86.3% of the data variance.

Conclusion

The developed wound analysis technique could be a viable tool in quantitative assessment of diabetic foot ulcers during healing.

http://ift.tt/2reSB38

Airborne gamma-ray spectrometry data processing using 1.5D inversion

Publication date: October 2017
Source:Journal of Environmental Radioactivity, Volume 177
Author(s): Eugene Druker
Standard processing of Airborne Gamma-Ray Spectrometry data generally gives good results when the measurement conditions are almost constant within several footprint area sizes, with the possible exception of flight height variations in a small range. In practice, deviations, such as large or abrupt changes of flight height and/or rugged terrain are not so rare and lead to certain problems. This article proposes a different approach where the solutions of inverse problems are used for data processing. The approach is quite natural in the processing of field data measured along the flight lines: it explicitly takes into account 1.5D survey models and flight parameters – from topography to sources distribution on the surface. Also, it clearly demonstrates that the inverse problem of the Airborne Gamma-Ray Spectrometry does not have a unique solution. This feature can be used in accordance with the underlying geological problem since various formulations of inverse problems can lead to various geological solutions. The use of the approach is illustrated by several examples given for flight lines and survey areas. This approach can be particularly useful in situations where geological, geophysical and/or geographic survey conditions are far from the standard assumptions.



http://ift.tt/2rhHeJU

Detection of gastric atrophy by circulating pepsinogens: A comparison of three assays

Abstract

Background

Circulating levels of pepsinogens have been used in high gastric cancer-risk Asian and European populations to triage endoscopic evaluation for more severe pathology. There are different analytic methods with uncertain correlations. We therefore compared diagnostic performance of three commonly used pepsinogen assays to detect histologically confirmed gastric atrophy.

Methods

We tested plasma samples from adult patients with (n=50) and without (n=755) moderate or severe gastric corpus atrophy, as determined histologically by consensus of three expert pathologists. A single laboratory measured pepsinogens I (PgI) and II (PgII) using commercially available assays: two ELISA assays produced by Biohit (Finland) and Vector Best (Russia), and a latex agglutination assay from Eiken (Japan). Quantitative correlations were assessed by Spearman statistics. Receiver operating characteristic (ROC) curves vs histological diagnosis were calculated using both the manufacturers' and optimized cutoffs.

Results

Pepsinogen levels were highly correlated among the assays (pairwise Rhos: PgI≥0.84, PgII≥0.87; all P-values<.01). Based on manufacturers' cutoffs, sensitivities, specificities and areas under the ROC curve for detecting moderate to severe histological corpus atrophy by PgI/PgII were 44%/91%/0.70, 56%/84%/0.76, and 52%/90%/0.77 for Biohit, Vector Best and Eiken, respectively. Cutoffs optimized by ROC or data mining analyses did not substantially improve test performance.

Conclusions

Commercial assays for pepsinogen have good relative agreement but are imperfect tests for clinical diagnosis of gastric atrophy.

Impact

Pepsinogen testing alone does not provide sufficient information for gastric cancer risk stratification. Future investigations should focus on other potential markers, in combination with pepsinogens.

http://ift.tt/2rhxjEd

Diseases of the retina and the optic nerve associated with obstructive sleep apnea

Many associations between ocular disorders and obstructive sleep apnea (OSA) have been studied, such as nonarteritic anterior ischemic optic neuropathy (NAION), glaucoma, papilledema, retinal vein occlusion, eyelid hyperlaxity, lower-eyelid ectropion and recurrent corneal erosions. The objective of this review is to synthetize the possible vascular disorders of the retina and the optic nerve associated with sleep apnea patients and to discuss the underlying pathophysiological hypotheses. Main mechanisms involved in the ocular complications of OSA are related to intermittent hypoxia, sympathetic system activation, oxidant stress, and deleterious effects of endothelin 1 (ET-1).

http://ift.tt/2s8C1lI

Effect of PICALM rs3851179 polymorphism on the default mode network function in mild cognitive impairment

Publication date: 28 July 2017
Source:Behavioural Brain Research, Volume 331
Author(s): Ding-Ming Sun, Hai-Feng Chen, Qi-Long Zuo, Fan Su, Feng Bai, Chun-Feng Liu
Alterations in default mode network (DMN) functional connectivity (FC) might accompany the dysfunction of Alzheimer's disease (AD). Indeed, episodic memory impairment is a hallmark of AD, and mild cognitive impairment (MCI) has been associated with a high risk for AD. Phosphatidylinositol-binding clathrin assembly protein (PICALM) (rs3851179) has been associated with AD; in particular, the A allele may serve a protective role, while the G allele serves as a strong genetic risk factor. Therefore, the identification of genetic polymorphisms associated with the DMN is required in MCI subjects. In all, 32 MCI subjects and 32 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging (rs-fMRI) and a genetic imaging approach. Subjects were divided into four groups according to the diagnosis (i.e., MCI and HCs) and the PICALM rs3851179 polymorphism (i.e., AA/AG genotype and GG genotype). The differences in FC within the DMN between the four subgroups were explored. Furthermore, we examined the relationship between our neuroimaging measures and cognitive performance. The regions associated with the genotype-by-disease interaction were in the left middle temporal gyrus (LMTG) and left middle frontal gyrus (LMFG). These changes in LMFG FC were generally manifested as an "inverse U-shaped curve", while a "U-shaped curve" was associated with the LMTG FC between these four subgroups (all P<0.05). Furthermore, higher FC within the LMFG was related to better episodic memory performance (i.e., AVLT 20min DR, rho=0.72, P=0.044) for the MCI subgroups with the GG genotype. The PICALM rs3851179 polymorphism significantly affects the DMN network in MCI. The LMFG and LMTG may be associated with opposite patterns. However, the altered LMFG FC in MCI patients with the GG genotype was more sensitive to episodic memory impairment, which is more likely to lead to a high risk of AD.



http://ift.tt/2relEnj

Role of cholinergic receptors in memory retrieval depends on gender and age of memory

Publication date: 28 July 2017
Source:Behavioural Brain Research, Volume 331
Author(s): Habiba Rashid, Aamra Mahboob, Touqeer Ahmed
The phenomenon of utilizing information acquired in the past to make decision and performance in present depends on memory retrieval, which is affected in retrograde amnesia. Role of cholinergic receptors in memory retrieval is not much explored. In this study we evaluated the gender specific role of cholinergic receptors, i.e. muscarinic and nicotinic receptors, in memory retrieval in young Balb/c mice. Acute (only one injection, 30min before test) and sub-chronic (five days) muscarinic blockade (using scopolamine=1mg/kg) before test impaired retrieval of contextual fear memory in male (31.45±5.39% and 33.36±3.78% respectively) and female mice (22.88±5.73%; P<0.05), except sub-chronically treated female group (33.31±4.90%; P>0.05). Only sub-chronic nicotinic receptor antagonism (using methyllycaconitine MLA=87.5μg/kg and dihydro β erythroidine DHβE=1mg/kg) in female showed significantly higher freezing response than control during contextual fear memory retrieval (60.85±7.71% and 40.91±7.53% respectively; P<0.001). Acute and sub-chronic muscarinic antagonism (but not nicotinic antagonism) impaired spatial memory retrieval in male (P<0.05) but not in female mice (P>0.05). There was no effect of acute and sub-chronic cholinergic receptor antagonism on discriminating novel object from the familiar one in male and female mice, however, nicotinic receptor blockade affected the working memory of all male and female mice on test day compared to the training sessions. Our results suggested that cholinergic receptors involvement in retrieving spatial and fear memories depends on the age of the memory and gender.



http://ift.tt/2qtz81y

Water and T-maze protocols are equally efficient methods to assess spatial memory in 3xTg Alzheimer’s disease mice

Publication date: 28 July 2017
Source:Behavioural Brain Research, Volume 331
Author(s): K.E. Davis, K. Burnett, J. Gigg
Rodent spatial memory is commonly tested using the water-maze; however, there is a potential confound of stress on learning in this behavioural paradigm. This is particularly relevant when testing spatial memory in models of neurodegeneration, such as the 3xTg mouse model for Alzheimer's disease. Here, we first confirmed that 3xTgAD mice express fear conditioning and then compared the performance of young and middle-aged mice on short-duration versions of the radial arm water-maze (RAWM) and the minimally stressful T-maze spontaneous alternation task. Our main questions were: (1) does the reliance on stressors in water-maze training mask the true cognitive ability of 3xTgAD mice; and (2) are 3xTgAD mice similarly impaired in water-maze and T-maze protocols. Firstly, male and female 3xTgAD mice displayed intact freezing responses in both contextual and Pavlovian fear conditions. As male 3xTgAD mice displayed relatively enhanced fear responses the remaining tests were performed using only female 3xTgAD and control mice in order to equate for response to stressors. We found that alternation rates after both short and long delays were impaired at both ages in female 3xTgAD mice, indicative of robust spatial working memory deficits. For RAWM, again performance deficits were found in young 3xTgAD mice. As both tasks had similar efficacy at revealing early spatial memory deficits, we suggest that spontaneous behavioural protocols be prioritised over water maze testing in models such the 3xTgAD mouse as the former provide a far less stressful but equally effective alternative.



http://ift.tt/2relQTD

Enriched environment alters the behavioral profile of tenascin-C deficient mice

Publication date: 28 July 2017
Source:Behavioural Brain Research, Volume 331
Author(s): V. Stamenkovic, I. Milenkovic, N. Galjak, V. Todorovic, P. Andjus
Tenascin-C (TnC) is an extracellular matrix glycoprotein implicated in a variety of processes ranging from brain development to synaptic plasticity in the adult vertebrates. Although the role of the TnC gene in regulation of behavior has been investigated, it remained elusive how TnC deficiency interacts with the environment in shaping the behavioral phenotype. To address this, 3-week-old TnC+/+ and TnC-/- male mice were housed over an 8-week period in standard conditions (SC), or enriched environment (EE). A comprehensive battery of tests was used in behavioral phenotyping. When housed in SC, TnC−/− mice showed spontaneous nocturnal hyperactivity, as well as poor sensorimotor coordination and low swimming velocity. However, housing of TnC−/− mice in EE abolished hyperlocomotion, led to faster habituation to novel environment, strengthened the grasp of fore limbs and partially improved movement coordination, while the swimming ability remained deficient. Conversely, TnC deficiency attenuated both the beneficial effects of EE on learning/memory capacity and the anxiolytic effect of EE in reducing the level of acrophobia. This study expands the existing knowledge about the phenotype associated with TnC deficiency, and reveals that the effect of genetic background on the behavioral response could be altered by post-weaning housing in a highly stimulating environment.



http://ift.tt/2qtutga

Scholar : Ειδοποίηση Μελετητή - [ ΠΡΟΣΩ

Ειδοποίηση Μελετητή:[ ΠΡΟΣΩΠΙΚΟ ΝΕΥΡΟ ]

[PDF] Ξηροφθαλμία και φακοί επαφής-Τι συμβαίνει στον φοιτητικό πληθυσμό του Αιγίου

ΣΑΜ Κροκίδη, ΑΑΜ Μετεβελή - 2017

... Θα θέλαμε να ευχαριστήσουμε αρχικά το διδακτικό προσωπικό του τμήματος και ιδιαίτερα την
επιβλέπουσα ... περιοχή του σκληρού που διατιτραίνεται απ' τις ίνες του οπτικού νεύρου ονομάζεται
ηθμοειδές ... Εκτείνεται από το ακτινωτό σώμα έως το οπτικό νεύρο και αιματώνει τις έξω ...

[PDF] Διαθλαστική εξέταση φοιτητών φυσικοθεραπείας: Ανάλυση αποτελεσμάτων ΙΙ

ΕΑΜ Μαυραγάνη, ΧΑΜ Φιτανίδου - 2017

... σε όλους τους φοιτητές και τις φοιτήτριες του τμήματος Φυσικοθεραπείας του Ανώτατου
Τεχνολογικού Ιδρύματος Δυτικής Ελλάδας που συστεγάζεται με το τμήμα Οπτικής και Οπτομετρίας
για τον προσωπικό και διδακτικό ... Οφθαλμικός βολβός ▪ Οπτικό νεύρο ▪ Μύες οφθαλμού ...

[PDF] Vision Training-Therapy

ΤΑΜ Σπάχο, ΊΑΜ Σαλτσάι, ΛΑΜ Γεωργίου - 2017

... Μια μελέτη μεγάλης επιστημονικής σημασίας, τόσο σε προσωπικό επίπεδο όσο και στο επίπεδο
του ... Επίσης, το οπτικό νεύρο αποτελείται από τους άξονες των γαγγλιακών κυττάρων, τα οποία ...
Οι ίνες του οπτικού νεύρου σχηματίζονται από τους άξονες των γαγγλιακών κυττάρων. ...

[PDF] Εκτίμηση αναγκών σε αιματολογικούς ασθενείς.

Α Ραμουτσάκη, Α Μαρνέλου, A Marnelou… - 2017

... Βενιζελείου και ΠαΓΝΗ, που μας εμπιστεύθηκαν και δέχτηκαν να συμμετάσχουν στην ερευνητική
μας εργασία, καθώς και το προσωπικό των αιματολογικών ... σύστημα και να εκδηλωθεί με ανωμαλίες
των κρανιακών νεύρων με κεφαλαλγία, ζάλη, ναυτία, διπλωπία. ...

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Scholar : Ειδοποίηση Μελετητή - [ Obstructiv

Ειδοποίηση Μελετητή:[ Obstructive sleep apnea ]

Reply: Obstructive Sleep Apnea in Adults: The Role of Upper Airway and Facial Skeletal Surgery

RK Garg, TW King, R Sanchez, AM Afifi - Plastic and Reconstructive Surgery, 2017

Indeed, polysomnography alone is not an ideal measure of treatment success because it is
poorly correlated with health outcomes. The apnea-hypopnea index is the most common
primary study endpoint, but success cannot be judged by strict criteria of apneahypopnea

[PDF] Influence of Obstructive Sleep Apnea Syndrome and Sleep Variables on Cognitive Performance and Psychological Distress in Severely Obese Patients

O Ribeiro, MR Carvalho, I do Carmo, G Horácio… - Research in Health Science, 2017

Abstract We examined the presence of the Obstructive Sleep Apnea Syndrome (OSAS) and
explored associations/correlations between sleep variables, anthropometric measures,
cognitive performance, and psychological distress in severely obese patients. We also

Device and method for correcting obstructive sleep apnea

MR Harrison, KH Rosenbluth, DA Kwiat, EJ Kezirian… - US Patent 9,655,767, 2017

Abstract: An orthotic obstructive sleep apnea treatment device is provided that includes a
hyoid bone attachment element disposed to attach a ferric element to a hyoid bone, where
the ferric element is disposed to face along a treatment vector from the hyoid bone, and the

Stroke and other cardiovascular events in patients with obstructive sleep apnea and the effect of continuous positive airway pressure

MH Schipper, K Jellema, BJW Thomassen… - Journal of Neurology, 2017

Abstract Obstructive sleep apnea (OSA) is a known-risk factor for cardiovascular diseases.
There are indications that treatment with continuous positive airway pressure (CPAP)
reduces the risk of new cardiovascular events. In this study, we analyzed the incidence of

Nurse versus physician‐led care for obstructive sleep apnea: A systematic review and meta‐analysis of randomised trials

F Gong, X Chen, Y Wu, D Yao, L Xie, Q Ouyang… - Journal of Advanced …, 2017

Aim To evaluate the effectiveness of nurse-led care for obstructive sleep apnoea compared
with physician-led care. Background The incidence of obstructive sleep apnoea is
increasing worldwide. There is a need for cost-effective care models to ease off the pressure

Obstructive Sleep Apnea is Associated with Improved Ischemic Stroke Outcomes (P4. 312)

D Low, M Elkind - Neurology, 2017

Objective: To evaluate the odds of death and poor discharge status among inpatients
diagnosed with ischemic stroke (IS) with or without obstructive sleep apnea (OSA).
Background: Hypoxic preconditioning has been demonstrated to induce stroke tolerance in

Night‐to‐night variability of obstructive sleep apnea

AS Stöberl, EI Schwarz, SR Haile, CD Turnbull… - Journal of Sleep Research, 2017

Summary One night of a sleep study is the standard for diagnosis and exclusion of
obstructive sleep apnea. Single testing requires high sensitivity of the test method and a
stable disease of interest to warrant a low rate of false-negative tests. Obstructive sleep

[HTML] Impact of Compression Stockings vs. Continuous Positive Airway Pressure on Overnight Fluid Shift and Obstructive Sleep Apnea among Patients on Hemodialysis

BC Silva, RSS Santos, LF Drager, FM Coelho… - Frontiers in Medicine, 2017

Introduction: Obstructive Sleep Apnea (OSA) is common in edematous states, notably in
hemodialysis patients. In this population, overnight fluid shift can play an important role on
the pathogenesis of OSA. The effect of compression stockings (CS) and continuous positive

Risk of obstructive sleep apnea among patients with Cushing's syndrome: A nationwide longitudinal study

LU Wang, TY Wang, YM Bai, JW Hsu, KL Huang, TP Su… - Sleep Medicine, 2017

Objective Previous studies have demonstrated the association between Cushing's
syndrome (CS), obstructive sleep apnea (OSA), and the risk factors for OSA, but rarely
provided the evidence within a large population. Using the Taiwan National Health

Short-Term Expiratory Muscle Strength Training Attenuates Sleep Apnea and Improves Sleep Quality in Patients with Obstructive Sleep Apnea

YC Kuo, TT Song, JR Bernard, PTYH Liaoo - Respiratory Physiology & Neurobiology, 2017

Abstract This study investigated the effects of 5 weeks of expiratory muscle strength training
(EMST) on sleep apnea, sleep quality, and respiratory muscle strength in patients with
different levels of obstructive sleep apnea (OSA). Twenty-five outpatients who received a

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