Low compliance to post‐screening recommendations in a family‐based Helicobacter pylori screening and treatment program: A prospective cohort study

alexandrossfakianakis shared this article with you from Inoreader Low compliance to post‐screening recommendations in a family‐based Helicobacter pylori screening and treatment program: A prospective cohort study via Helicobacter Abstract Background Intra-family transmission is an important Helicobacter pylori (H. pylori) infection route. Family-based screening and treatment of H. pylori is a promising strategy. However, limited data are available on patient compliance with post-screening recommendations for such a strategy. Materials and Methods A prospective cohort study of families from six regions in Shandong, China, from July 2021 to February 2022 was conducted. Demographic characteristics, prior testing, and treatment for H. pylori, prior gastroscopy, symptoms, and family history were collected. Infection status of participants was determined using the 13C-urea breath test. Infected participants were recommended to undergo eradication treatment, confirmation testing, and gastroscopy per expert consensus. Participants were monitored for 6 months to record recommendation compliance in a real-world setting. Logistic regression models were used to analyze the factors influencing compliance with the recommendations. Results The study included 1173 individuals from 386 families with the overall infection rate of 36.7%. The recommendation compliance for eradication treatment, confirmation testing, and gastroscopy was 69.3% (271/391), 32.5% (88/271), and 6.1% (19/309), respectively. Factors that increased the risk of lower compliance were male sex (odds ratio [OR], 1.917, 95% confidence interval [CI], 1.233–2.981), and living in a non-urban area (OR, 1.954, 95% CI, 1.241–3.074), for treatment recommendations; having more than one infected family member (OR, 2.138, 95% CI, 1.237–3.698), and a lower family income (¥100,000–¥300,000 per year, OR, 7.247, 95% CI, 1.788–29.363; or <¥100,000 per year, OR, 7.294, 95% CI, 1.832–29.042), for confirmation testing recommendations; and being asymptomatic (OR, 3.009, 95% CI, 1.105–8.196), for gastroscopy recommendations. Conclusions Post-screening recommendation compliance for this family-based H. pylori screening and treatment program was unsatisfactory. Further studies focusing on pre-screening education are warranted to improve compliance. View on Web

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Dilation, Steroid Injection, and Cough Exercise for Correction of Posterior Glottic Stenosis

alexandrossfakianakis shared this article with you from Inoreader Dilation, Steroid Injection, and Cough Exercise for Correction of Posterior Glottic Stenosis via The Laryngoscope DISCO (Dilation, Steroid injection and post-operative Cough Exercise) is a novel protocol for correcting posterior glottic stenosis. Post-op cough acts as physical-therapy to improve motion and flexibility. It can restore mobility and expand glottic airway without insufficiency. Objective To describe the DISCO protocol (Dilation, Steroid injection, and post-operative Cough Exercise); a novel treatment for posterior glottic stenosis (PGS). Restoring glottic mobility in PGS is a major challenge. In orthopedic and plastic surgery, post-operative physical therapy is associated with improved motion range and flexibility; yet, this principle was never applied to laryngeal surgery. Methods A retrospective cohort of PGS adult patients, treated by the DISCO protocol during 2018–2020. DISCO involves the following: scar release, glottic dilation, and steroid injection, followed by post-operative cough as glottic physical therapy. Maximal glottic opening angle (MGOA), relative glottic opening area (RGOA), and relative glottic insufficiency area (RGIA) were calculated before and post-operatively. Results Seventeen patients were included; PGS etiology was post-intubation (n = 10), post-irradiation (n = 3), both (n = 1) and joint sclerosis (n = 3). Six patients also had additional airway disorders. Sixteen patients were tracheostomy-dependent. 2 (12%), 8 (47%) and 7 (41%) patients had type II, III and IV stenosis, respectively. Surgery included scar release, dilation and steroid injection alone in 7 patients; and additional unilateral sub-mucosal arytenoidectomy in 10. The mean follow-up was 17.5 months. There were no major complications. Successful outcomes (e.g., decannulation or permanent capping) were achieved in 14 (82%) patients with some restoration of joint movement. None had a persistent voice or swallowing complaints. Both MGOA and RGOA increased in all patients (p < 0.001). RGIA remained unchanged (p = 0.878). Conclusions The DISCO protocol is a novel, effective and safe approach for PGS correction that can be easily applied. It can restore vocal fold mobility and may expand the glottic airway without causing glottic insufficiency. Level of Evidence 4 Laryngoscope, 2022 View on Web

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Hospira Issues a Voluntary Nationwide Recall for One Lot of Propofol Injectable Emulsion, USP (Containing Benzyl Alcohol), Due to the Potential Presence of Visible Particulate

alexandrossfakianakis shared this article with you from Inoreader Hospira Issues a Voluntary Nationwide Recall for One Lot of Propofol Injectable Emulsion, USP (Containing Benzyl Alcohol), Due to the Potential Presence of Visible Particulate via Food and Drug Administration--Recalls/Safety Alerts Hospira, Inc., a Pfizer company, is voluntarily recalling one lot of Propofol Injectable Emulsion, USP (containing benzyl alcohol) to the user level due to a visible particulate observed in a single vial during annual examination of retain samples View on Web

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Polymethylmethacrylate denture base layering as a new approach for the addition of antifungal agents

alexandrossfakianakis shared this article with you from Inoreader Polymethylmethacrylate denture base layering as a new approach for the addition of antifungal agents via Journal of Prosthodontics Abstract Purpose To introduce a new technique, denture base layering, for the addition of titanium dioxide nanoparticles (TiO2NPs) to polymethylmethacrylate (PMMA) and to investigate the effects of the layering technique on Candida albicans (C. albicans) adhesion and on surface roughness, hardness, translucency, and flexural strength. Materials & Methods In total, 210 heat-polymerized acrylic resin specimens were prepared as discs (15 × 2 mm) for testing C. albicans adhesion (n = 70) and surface roughness, hardness, and translucency (n = 70); and as acrylic plates (65 × 10 × 2.5 mm) for testing flexural strength (n = 70). Specimens were divided into 4 groups: control (n = 30), one-layer (n = 60), double-layer (n = 60), and dotted-layer (n = 60) according to the packing and layering technique. Each group was divided according to the concentration of TiO2NPs 1% and 2.5% (n = 10). The control group comprised one layer of unmodified resin. The one-layer group comprised one layer of a mixture of PMMA/TiO2NPs packed conventionally. The double-layer group consisted of two different layers packed in two steps, as follows: unmodified resin first, followed by a continuous thin layer of the PMMA/TiO2NPs mixture. Similarly, the dotted-layer group consisted of two di fferent layers packed in two steps, as follows: unmodified resin first, followed by a thin layer of the PMMA/TiO2NPs. However, the second mixture was added in a dotted manner. The direct culture method for C. albicans adhesion before and after ultraviolet light activation, and surface roughness, hardness, translucency, and flexural strength were measured. An analysis of variance and Tukey's post hoc test were used for data analysis (α = 0.05). Results The addition of TiO2NPs reduced C. albicans adhesion (P ˂.001). However, no significant difference was found between both concentrations within the same group before and after ultraviolet light activation (P >0.05), except in the 1% dotted-layer (P = .022). Surface roughness and hardness were not affected by the additions of different concentrations of TiO2NPs (P = .905) and (P = .059), respectively. Translucency was significantly reduced in all the groups (P ˂.001) except in the 1% dotted-layer (P = .332). Flexural strength decreased as the TiO2NPs concentration increased, with the greatest reduction in strength observed in the one-layer group (P ˂.001). Conclusions The double and dotted layering techniques were effective in reducing C. albicans adhesion, without affecting surface roughness, hardness, or flexural strength. However, translucency was reduced in all the groups, except the 1% dotted-layer group. This article is protected by copyright. All rights reserved View on Web

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