Recent investigations are focused on the potential antitumor effect of neurokinin-1 receptor (NK1R) antagonists in different neoplastic diseases1. Consequently, Kwatra et al. raised an interesting observation about the possible influence of aprepitant on CTCL outcome2.
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Itch pathogenesis involves modulation of the neuroimmune axis, with several immunosuppressants such as azathioprine1 and mycophenolate mofetil2 demonstrating significant anti-pruritic activity in subsets of patients with pruritus. These immunosuppressive agents are contraindicated in patients with malignancy, and thus there is a need for novel anti-pruritic agents without significant immunosuppressive effects in neoplastic conditions such as cutaneous T cell lymphoma (CTCL).
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Publication date: 15 March 2018
Source:Materials & Design, Volume 142
Author(s): W.W. Xu, S.L. Shang, C.P. Wang, T.Q. Gang, Y.F. Huang, L.J. Chen, X.J. Liu, Z.K. Liu
The discovery of γ′-Co3(Al,W) opens up a pathway to exploit novel Co-Al-based alloys as candidates of the next generation of superalloys. Inspired by the unexpected finding of γ′-Co3(Al,W), we present a comprehensive investigation concerning the effect of alloying elements on phase stabilities and mechanical properties of Co3Al. Up to 22 transition metal elements, e.g. Sc, Ti, V, Cr, Mn, Fe, Ni, Y, Zr, Nb, Mo, Tc, Ru, Rh, Pd, Hf, Ta, W, Re, Os, Ir, and Pt, are considered. Results show that W, Ti, Re, V, and Ta favor to occupy the Al-sublattice. Pd, Pt, Rh, Ni, Ir, Fe, and Ru favor to occupy the Co-sublattice. The others can occupy both the Co- and Al-sublattices. W, Ta, V, Ti, Nb, Re, Mo, Pt, and Cr are shown to stabilize Co3Al. It verifies that elastic properties are roughly in inverse proportional to the volume change induced by alloying elements within each group of 3d, 4d, or 5d. Based on the analysis of electronic configurations, the influence mechanism of alloying elements is traceable from the chemical bonding and the geometry of charge density. The present calculations are in favorable accord with available experimental data in the literature.
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Αυτή η ειδοποίηση αποστέλλεται από τον Μελετητή Google. Ο Μελετητής Google είναι μια υπηρεσία που παρέχεται από την Google.
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Αυτή η ειδοποίηση αποστέλλεται από τον Μελετητή Google. Ο Μελετητής Google είναι μια υπηρεσία που παρέχεται από την Google.
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Αυτή η ειδοποίηση αποστέλλεται από τον Μελετητή Google. Ο Μελετητής Google είναι μια υπηρεσία που παρέχεται από την Google.
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Αυτή η ειδοποίηση αποστέλλεται από τον Μελετητή Google. Ο Μελετητής Google είναι μια υπηρεσία που παρέχεται από την Google.
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Αυτή η ειδοποίηση αποστέλλεται από τον Μελετητή Google. Ο Μελετητής Google είναι μια υπηρεσία που παρέχεται από την Google.
