Investigation and analysis of 1030 primary hair transplantation cases: a retrospective study

Abstract

Background

Hair transplantation has progressed since the introduction of the concept of follicular unit transplantation, a method that recognizes the follicular unit as the basic element of tissue to be transferred. It was aimed to estimate the area of donor scalp with the greatest probability contains the number of follicular units desired to transplant and to analyze the complications in all patients who underwent hair transplantation procedure.

Methods

A retrospective study was conducted in our clinic from January 2014 to January 2018.

Results

One thousand thirty hair restoration procedures were performed. Each patient was evaluated for age and gender in addition to the follicular unit density and postoperative complication rates. The mean age was 37.2 years. It was noted that the most common type of hair grouping was the 2-hair follicular unit grafts. The FU density ranged between 70 and 90 and the hair density ranged between 130 and 220 hair/cm². Postoperative frontal edema was the most common postoperative complication.

Conclusions

Data collected from this series can help to estimate the area of donor scalp with the greates probability of containing the number of follicular units desired to transplant.

Level of Evidence: Level IV, therapeutic study.

https://ift.tt/2SmUKXs

An update of the pathogenesis of frontal fibrosing alopecia: What does the current evidence tell us?

Australasian Journal of Dermatology, EarlyView.


https://ift.tt/2z4xXHh

Antiaging Effects of Urolithin A on Replicative Senescent Human Skin Fibroblasts

Rejuvenation Research, Ahead of Print.


https://ift.tt/2qbrqXh

Aloe-Emodin Ameliorates Renal Fibrosis Via Inhibiting PI3K/Akt/mTOR Signaling Pathway In Vivo and In Vitro

Rejuvenation Research, Ahead of Print.


https://ift.tt/2Rjd5DL

Use of calcium hydroxylapatite in the upper third of the face: Retrospective analysis of techniques, dilutions and adverse events

Journal of Cosmetic Dermatology, EarlyView.


https://ift.tt/2EIzQ2g

Relevance of TSH evaluation in elderly in-patients with non-thyroidal illness

Abstract

Background

Non-thyroidal illness (NTI) is frequent in hospitalized patients. Its recovery is characterized by a raise in TSH levels. However, the clinical significance of high TSH levels at admission in hospitalized elderly patients with NTI remains uncertain.

Aim

To explore the relevance of baseline TSH evaluation in hospitalized elderly patients with NTI.

Methods

We examined the participants with NTI (n = 123) from our previous study (Sforza, 2017). NTI was defined as: low T3 (< 80 ng/dL) and normal or low total T4 in the presence of TSH values between 0.1 and 6.0 mU/L. Thyroid function tests were performed on day 1 and day 8 of the hospital stay. Positive TSH changes (+ ΔTSH) were considered when the day-8 TSH value increased more than the reference change value for TSH (+ 78%). Multiple logistic regression was used to evaluate the independent association of baseline TSH, sex, clinical comorbidities (by ACE-27) and medications with + ΔTSH.

Results

Out of 123 patients (77 ± 8 years, 52% female), 34 showed a + ΔTSH. These patients had a lower TSH at admission (p < 0.001) and intra-hospital mortality (p = 0.003) than the others. In multiple logistic regression, TSH > 2.11 mU/L at baseline was associated with reduced odds to show + ΔTSH [odds ratio (95 CI) 0.29 (0.11–0.75); p = 0.011] in a model adjusted by age, sex and ACE-27.

Discussion

Inappropriately higher TSH levels at admission in hospitalized elderly patients were associated with a reduced ability to raise their TSH levels later on. The present results confront the idea that TSH levels at admission are irrelevant in this clinical context.

https://ift.tt/2qbmT77

Multiple yellow nodules in a 13‐year‐old girl

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2OMP2QG

Painful papule on the right arm of a woman

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2O7mYCj

Human papilloma virus infection in the healing thermal‐burn wound in a child

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2OPRtlH

Phase II Trial of 5‐Fluorouracil, Docetaxel, and Nedaplatin (UDON) Combination Therapy for Recurrent or Metastatic Esophageal Cancer

Lessons Learned. The 5‐fluorouracil, docetaxel, and nedaplatin (UDON) regimen was well tolerated and showed promising antitumor activity in terms of both objective response rate and survival for patients with advanced or recurrent esophageal squamous cell carcinoma in the first‐line setting.UDON may be an optimal treatment option for patients with advanced esophageal cancer who are unfit for docetaxel, cisplatin, and 5‐fluorouracil regimens.The high response rate as well as the rapid and marked tumor shrinkage associated with UDON suggest that further evaluation of this regimen in the neoadjuvant setting is warranted.Background.A phase II study was performed to evaluate the efficacy and safety of 5‐fluorouracil (5‐FU), docetaxel, and nedaplatin (UDON) combination therapy for untreated recurrent or metastatic esophageal cancer.Methods.Patients received intravenous nedaplatin (90 mg/m2) on day 1, docetaxel (35 mg/m2) on days 1 and 15, and 5‐fluorouracil (800 mg/m2) on days 1–5 of a 4‐week cycle. The primary endpoint was response rate, with secondary endpoints including overall survival (OS), progression‐free survival (PFS), dysphagia score, and adverse events.Results.Between March 2015 and July 2017, 23 patients were enrolled. Of 22 evaluable patients, 16 and 4 individuals experienced a partial response and stable disease, respectively, yielding a response rate of 72.7% (95% confidence interval [CI], 49.8%–89.3%) and disease control rate of 90.9% (95% CI, 70.8%–98.9%). Median OS and PFS were 11.2 months (95% CI, 9.1 months to not reached) and 6.0 months (95% CI, 2.5–10.6 months), respectively. Eleven (64.7%) of the 17 patients with a primary lesion showed amelioration of dysphagia after treatment. Frequent adverse events of grade 3 or 4 included neutropenia (87.0%) and leukopenia (39.1%). Febrile neutropenia was observed in two patients (8.7%).Conclusion.This phase II study demonstrated promising antitumor activity and good tolerability of UDON.

https://ift.tt/2PpctyZ

More Press Coverage from the 88th Annual Meeting of the ATA

 From endocrineweb

Combination Immunotherapies to Treat Advanced Thyroid Cancers

Diet for Thyroid Disease: What You Need to Know

Matching Expectations and Guidelines to Treatment-Worthy Thyroid Cancers

Liver Failure: A Turning Point in Graves' Disease Treatment

 

The post More Press Coverage from the 88th Annual Meeting of the ATA appeared first on American Thyroid Association.

https://ift.tt/2RhD8v8

Comparison of treatment plans for a high-field MRI-linac and a conventional linac for esophageal cancer

Abstract

Purpose

To compare radiotherapy treatments plans in esophageal cancer calculated for a high-field magnetic resonance imaging (MRI)-linac with plans for a conventional linac.

Materials and methods

Ten patients with esophageal squamous cell carcinomas were re-planned retrospectively using the research version of Monaco (V 5.19.03, Elekta AB, Stockholm, Sweden). Intensity modulated radiotherapy (IMRT) plans with a nine-field step-and-shoot technique and two-arc volumetric modulated arc therapy (VMAT) plans were created for the Elekta MRI-linac and a conventional linac, respectively. The prescribed dose was 60 Gy to the primary tumor (PTV₆₀) and 50 Gy to elective volumes (PTV₅₀). Plans were optimized for optimal coverage of the 60 Gy volume and compared using dose–volume histogram parameters.

Results

All calculated treatment plans met predefined criteria for target volume coverage and organs at risk dose both for MRI-linac and conventional linac. Plans for the MRI-linac had a lower number of segments and monitor units. No significant differences between both plans were seen in terms of V_20Gy of the lungs and V_40Gy of the heart with slightly higher mean doses to the heart (14.0 Gy vs. 12.5 Gy) and lungs (12.8 Gy vs. 12.2 Gy).

Conclusion

Applying conventional target volume and margin concepts as well as dose-fractionation prescription reveals clinically acceptable dose distributions using hybrid MRI-linac in its current configuration compared to standard IMRT/VMAT. This represents an important prerequisite for future studies to investigate the clinical benefit of MRI-guided radiotherapy exploiting the conceptional advantages such as reduced margins, plan adaptation and biological individualization and hypofractionation.

https://ift.tt/2z2tQvu

Use-Dependent Plasticity in Human Primary Motor Hand Area: Synergistic Interplay Between Training and Immobilization

Abstract

Training and immobilization are powerful drivers of use-dependent plasticity in human primary motor hand area (M1_HAND). In young right-handed volunteers, corticomotor representations of the left first dorsal interosseus and abductor digiti minimi muscles were mapped with neuronavigated transcranial magnetic stimulation (TMS) to elucidate how finger-specific training and immobilization interact within M1_HAND. A first group of volunteers trained to track a moving target on a smartphone with the left index or little finger for one week. Linear sulcus shape-informed TMS mapping revealed that the tracking skill acquired with the trained finger was transferred to the nontrained finger of the same hand. The cortical representations of the trained and nontrained finger muscle converged in proportion with skill transfer. In a second group, the index or little finger were immobilized for one week. Immobilization alone attenuated the corticomotor representation and pre-existing tracking skill of the immobilized finger. In a third group, the detrimental effects of finger immobilization were blocked by concurrent training of the nonimmobilized finger. Conversely, immobilization of the nontrained fingers accelerated learning in the adjacent trained finger during the first 2 days of training. Together, the results provide novel insight into use-dependent cortical plasticity, revealing synergistic rather than competitive interaction patterns within M1_HAND.

https://ift.tt/2RdtSYU

Neural Dynamics of Reward-Induced Response Activation and Inhibition

Abstract

Reward-predictive stimuli can increase an automatic response tendency, which needs to be counteracted by effortful response inhibition when this tendency is inappropriate for the current task. Here we investigated how the human brain implements this dynamic process by adopting a reward-modulated Simon task while acquiring EEG and fMRI data in separate sessions. In the Simon task, a lateral target stimulus triggers an automatic response tendency of the spatially corresponding hand, which needs to be overcome if the activated hand is opposite to what the task requires, thereby delaying the response. We associated high or low reward with different targets, the location of which could be congruent or incongruent with the correct response hand. High-reward targets elicited larger Simon effects than low-reward targets, suggesting an increase in the automatic response tendency induced by the stimulus location. This tendency was accompanied by modulations of the lateralized readiness potential over the motor cortex, and was inhibited soon after if the high-reward targets were incongruent with the correct response hand. Moreover, this process was accompanied by enhanced theta oscillations in medial frontal cortex and enhanced activity in a frontobasal ganglia network. With dynamical causal modeling, we further demonstrated that the connection from presupplementary motor area (pre-SMA) to right inferior frontal cortex (rIFC) played a crucial role in modulating the reward-modulated response inhibition. Our results support a dynamic neural model of reward-induced response activation and inhibition, and shed light on the neural communication between reward and cognitive control in generating adaptive behaviors.

https://ift.tt/2ONov5Z

Cultural variation in the gray matter volume of the prefrontal cortex is moderated by the dopamine D4 receptor gene (DRD4)

Abstract

Recent evidence suggests a systematic cultural difference in the volume/thickness of prefrontal regions of the brain. However, origins of this difference remain unclear. Here, we addressed this gap by adopting a unique genetic approach. People who carry the 7- or 2-repeat (7/2-R) allele of the dopamine D4 receptor gene (DRD4) are more sensitive to environmental influences, including cultural influences. Therefore, if the difference in brain structure is due to cultural influences, it should be moderated by DRD4. We recruited 132 young adults (both European Americans and Asian-born East Asians). Voxel-based morphometry showed that gray matter (GM) volume of the medial prefrontal cortex and the orbitofrontal cortex was significantly greater among European Americans than among East Asians. Moreover, the difference in GM volume was significantly more pronounced among carriers of the 7/2-R allele of DRD4 than among non-carriers. This pattern was robust in an alternative measure assessing cortical thickness. A further exploratory analysis showed that among East Asian carriers, the number of years spent in the U.S. predicted increased GM volume in the orbitofrontal cortex. The present evidence is consistent with a view that culture shapes the brain by mobilizing epigenetic pathways that are gradually established through socialization and enculturation.

https://ift.tt/2RgR7kJ

Transient and Sustained Control Mechanisms Supporting Novel Instructed Behavior

Abstract

The success of humans in novel environments is partially supported by our ability to implement new task procedures via instructions. This complex skill has been associated with the activity of control-related brain areas. Current models link fronto-parietal and cingulo-opercular networks with transient and sustained modes of cognitive control, based on observations during repetitive task settings or rest. The current study extends this dual model to novel instructed tasks. We employed a mixed design and an instruction-following task to extract phasic and tonic brain signals associated with the encoding and implementation of novel verbal rules. We also performed a representation similarity analysis to capture consistency in task-set encoding within trial epochs. Our findings show that both networks are involved while following novel instructions: transiently, during the implementation of the instruction, and in a sustained fashion, across novel trials blocks. Moreover, the multivariate results showed that task representations in the cingulo-opercular network were more stable than in the fronto-parietal one. Our data extend the dual model of cognitive control to novel demanding situations, highlighting the high flexibility of control-related regions in adopting different temporal profiles.

https://ift.tt/2OOAhgg

Visual and Vestibular Selectivity for Self-Motion in Macaque Posterior Parietal Area 7a

Abstract

We examined the responses of neurons in posterior parietal area 7a to passive rotational and translational self-motion stimuli, while systematically varying the speed of visually simulated (optic flow cues) or actual (vestibular cues) self-motion. Contrary to a general belief that responses in area 7a are predominantly visual, we found evidence for a vestibular dominance in self-motion processing. Only a small fraction of neurons showed multisensory convergence of visual/vestibular and linear/angular self-motion cues. These findings suggest possibly independent neuronal population codes for visual versus vestibular and linear versus angular self-motion. Neural responses scaled with self-motion magnitude (i.e., speed) but temporal dynamics were diverse across the population. Analyses of laminar recordings showed a strong distance-dependent decrease for correlations in stimulus-induced (signal correlation) and stimulus-independent (noise correlation) components of spike-count variability, supporting the notion that neurons are spatially clustered with respect to their sensory representation of motion. Single-unit and multiunit response patterns were also correlated, but no other systematic dependencies on cortical layers or columns were observed. These findings describe a likely independent multimodal neural code for linear and angular self-motion in a posterior parietal area of the macaque brain that is connected to the hippocampal formation.

https://ift.tt/2Res7dE

The Corticospinal Discrepancy: Where are all the Slow Pyramidal Tract Neurons?

Abstract

This feature article focuses on the discrepancy between the distribution of axon diameters within the primate corticospinal tract, determined neuroanatomically, and the distribution of axonal conduction velocities within the same tract, determined electrophysiologically. We point out the importance of resolving this discrepancy for a complete understanding of corticospinal functions, and discuss the various explanations for the mismatch between anatomy and physiology.

https://ift.tt/2ONKMR8

Precision Inhibitory Stimulation of Individual-Specific Cortical Hubs Disrupts Information Processing in Humans

Abstract

Noninvasive brain stimulation (NIBS) is a promising treatment for psychiatric and neurologic conditions, but outcomes are variable across treated individuals. In principle, precise targeting of individual-specific features of functional brain networks could improve the efficacy of NIBS interventions. Network theory predicts that the role of a node in a network can be inferred from its connections; as such, we hypothesized that targeting individual-specific "hub" brain areas with NIBS should impact cognition more than nonhub brain areas. Here, we first demonstrate that the spatial positioning of hubs is variable across individuals but reproducible within individuals upon repeated imaging. We then tested our hypothesis in healthy individuals using a prospective, within-subject, double-blind design. Inhibition of a hub with continuous theta burst stimulation disrupted information processing during working-memory more than inhibition of a nonhub area, despite targets being separated by only a few centimeters on the right middle frontal gyrus of each subject. Based upon these findings, we conclude that individual-specific brain network features are functionally relevant and could leveraged as stimulation sites in future NIBS interventions.

https://ift.tt/2Rl0hNh

Is Human Auditory Cortex Organization Compatible With the Monkey Model? Contrary Evidence From Ultra-High-Field Functional and Structural MRI

Abstract

It is commonly assumed that the human auditory cortex is organized similarly to that of macaque monkeys, where the primary region, or "core," is elongated parallel to the tonotopic axis (main direction of tonotopic gradients), and subdivided across this axis into up to 3 distinct areas (A1, R, and RT), with separate, mirror-symmetric tonotopic gradients. This assumption, however, has not been tested until now. Here, we used high-resolution ultra-high-field (7 T) magnetic resonance imaging (MRI) to delineate the human core and map tonotopy in 24 individual hemispheres. In each hemisphere, we assessed tonotopic gradients using principled, quantitative analysis methods, and delineated the core using 2 independent (functional and structural) MRI criteria. Our results indicate that, contrary to macaques, the human core is elongated perpendicular rather than parallel to the main tonotopic axis, and that this axis contains no more than 2 mirror-reversed gradients within the core region. Previously suggested homologies between these gradients and areas A1 and R in macaques were not supported. Our findings suggest fundamental differences in auditory cortex organization between humans and macaques.

https://ift.tt/2OQfIA7

Continuity and Discontinuity in Human Cortical Development and Change From Embryonic Stages to Old Age

Abstract

The human cerebral cortex is highly regionalized, and this feature emerges from morphometric gradients in the cerebral vesicles during embryonic development. We tested if this principle of regionalization could be traced from the embryonic development to the human life span. Data-driven fuzzy clustering was used to identify regions of coordinated longitudinal development of cortical surface area (SA) and thickness (CT) (n = 301, 4–12 years). The principal divide for the developmental SA clusters extended from the inferior–posterior to the superior–anterior cortex, corresponding to the major embryonic morphometric anterior–posterior (AP) gradient. Embryonic factors showing a clear AP gradient were identified, and we found significant differences in gene expression of these factors between the anterior and posterior clusters. Further, each identified developmental SA and CT clusters showed distinguishable life span trajectories in a larger longitudinal dataset (4–88 years, 1633 observations), and the SA and CT clusters showed differential relationships to cognitive functions. This means that regions that developed together in childhood also changed together throughout life, demonstrating continuity in regionalization of cortical changes. The AP divide in SA development also characterized genetic patterning obtained in an adult twin sample. In conclusion, the development of cortical regionalization is a continuous process from the embryonic stage throughout life.

https://ift.tt/2R9VtKc

High-Expanding Regions in Primate Cortical Brain Evolution Support Supramodal Cognitive Flexibility

Abstract

Primate cortical evolution has been characterized by massive and disproportionate expansion of a set of specific regions in the neocortex. The associated increase in neocortical neurons comes with a high metabolic cost, thus the functions served by these regions must have conferred significant evolutionary advantage. In the present series of analyses, we show that evolutionary high-expanding cortex – as estimated from patterns of surface growth from several primate species – shares functional connections with different brain networks in a context-dependent manner. Specifically, we demonstrate that high-expanding cortex is characterized by high internetwork functional connectivity; is recruited flexibly over many different cognitive tasks; and changes its functional coupling pattern between rest and a multimodal task-state. The capacity of high-expanding cortex to connect flexibly with various specialized brain networks depending on particular cognitive requirements suggests that its selective growth and sustainment in evolution may have been linked to an involvement in supramodal cognition. In accordance with an evolutionary-developmental view, we find that this observed ability of high-expanding regions – to flexibly modulate functional connections as a function of cognitive state – emerges gradually through childhood, with a prolonged developmental trajectory plateauing in young adulthood.

https://ift.tt/2ORFgwP

Glucocorticoid activation by 11β‐hydroxysteroid dehydrogenase enzymes in relation to inflammation and glycaemic control in chronic kidney disease: a cross‐sectional study

Clinical Endocrinology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2PoBeeO

Clinical practice update on testosterone therapy for male hypogonadism: contrasting perspectives to optimise care

Clinical Endocrinology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2EMKW6J

Paediatric‐onset and adult‐onset Graves’ disease share multiple genetic risk factors

Clinical Endocrinology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2PpiknW

Immunosuppressive therapy of autoimmune hypoparathyroidism in a patient with activating autoantibodies against the calcium‐sensing receptor

Clinical Endocrinology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2EJHOs7

miR-21 expression analysis in budding colon cancer cells by confocal slide scanning microscopy

Abstract

MicroRNA-21 (miR-21) expression in stromal fibroblastic cells in colorectal cancer is well-documented, whereas miR-21 expression in tumor budding cells (TBCs) is poorly described. TBCs are locally invasive carcinoma cells with increased metastatic properties and characteristics of epithelial to mesenchymal transition. This study was conducted to better characterize the expression of miR-21 in TBCs. First, chromogenic miR-21 in situ hybridization (ISH) staining was performed in 58 colon adenocarcinomas with evident TBCs. Then, to obtain unambiguous identification of miR-21 in the TBCs, twenty cases were selected for an additional multiplex fluorescence analysis combining miR-21 ISH with cytokeratin and laminin-5γ2 immunofluorescence. Employing confocal slide scanning microscopy, comprehensive digital images of the invasive front (10–40 mm²) were obtained from 16 of the 20 cases, and miR-21 expression was evaluated in cytokeratin-positive TBCs. The high resolution of the confocal digital slide images allowed a detailed examination of the confocal stacks of the multiplex-stained tissue sections. The cases with the highest fraction of miR-21 positive TBCs were all stage III cancers defined by the presence of regional lymph node metastasis. Some of the miR-21 positive TBCs were also laminin-5γ2 positive. The confocal image stacks also revealed that some TBCs were actually directly connected to malignant glands. In conclusion, miR-21 expression was unambiguously identified in TBCs by evaluation of digital slides obtained by confocal slide scanning microscopy. In addition, the digital confocal slides provided a more detailed understanding of local cancer cell invasion by allowing evaluation of the cell structures in three dimensions.

https://ift.tt/2D5sl3Z

Pacritinib in Patients With Myelofibrosis

To the Editor In the phase 3 PERSIST-2 study reported by Mascarenhas et al, a Janus kinase 2 (JAK2) inhibitor, pacritinib, was more effective than best available therapy (BAT), including a JAK1 and JAK2 inhibitor, ruxolitinib, for reducing the size of the spleen and subjective symptoms in patients with myelofibrosis who had intermediate- or high-risk disease and moderate to severe thrombocytopenia. We have several concerns about this randomized clinical trial.

https://ift.tt/2Jg7ETg

Pacritinib in Patients with Myelofibrosis—Reply

In Reply We thank Dr Suzuki and colleagues for their comments regarding our article. Their assumption regarding reduced incidence of herpes zoster infection in patients treated with pacritinib relative to ruxolitinib or other Janus kinase 1/2 inhibitors is borne out by the clinical data: the incidence of herpes zoster infection in the PERSIST-2 trial was 0%, 1%, and 1% in the pacritinib 200 mg twice daily, 400 mg once daily, and best available therapy arms, respectively (unpublished data, CTI BioPharma Corp, clinical study report for PERSIST-2 trial, November 2016). Although some patients in the best available therapy arm received ruxolitinib, their exposure was predominantly low dose and of short duration owing to the high crossover rate to pacritinib after 24 weeks. In the overall clinical trial experience with pacritinib in patients with myelofibrosis (n = 692), the incidence of herpes zoster infection was 0.6% with median pacritinib treatment of 8.3 months (maximum treatment, 3.3 years). The incidence of other opportunistic infections has been similarly low.

https://ift.tt/2PkAIyf

Redefining the Role of Prophylactic Cranial Irradiation in the Era of Active Surveillance in SCLC

This Viewpoint discusses the role of prophylactic cranial irradiation in small cell lung cancer in the current setting of active surveillance via magnetic resonance imaging.

https://ift.tt/2Jg7Ce6

Bevacizumab vs Cetuximab Plus Chemotherapy in KRAS Wild-Type mCRC

This open-label, randomized phase 2 trial evaluates progression-free survival with chemotherapy plus bevacizumab vs cetuximab among patients with progression of metastatic colorectal cancer (mCRC) after bevacizumab plus chemotherapy.

https://ift.tt/2PkAGq7

Surviving Cancer in the Midst of a Treatment Revolution: Hope and Delusion

In this article, the author discusses his struggles with hope and delusion in his personal experience with renal cell carcinoma.

https://ift.tt/2Jg7AD0

Nivolumab Monotherapy in Patients With Previously Untreated BRAF Wild-Type Advanced Melanoma

This follow-up of a randomized phase 3 trial compares the 3-year survival with nivolumab vs that with dacarbazine in patients with previously untreated BRAF wild-type advanced melanoma.

https://ift.tt/2PouJZl

The immunobiology of female predominance in primary biliary cholangitis

Publication date: Available online 25 October 2018

Source: Journal of Autoimmunity

Author(s): Alessio Gerussi, Laura Cristoferi, Marco Carbone, Rosanna Asselta, Pietro Invernizzi

Abstract

Primary biliary cholangitis (PBC) is an autoimmune liver disease with a striking female preponderance. The mechanisms behind this predominance are still to be elucidated, although multiple theories have been postulated and investigated. Among the proposed involved factors, sex hormones have been the first to be studied, but unfortunately data have been inconclusive or conflicting. Similarly, fetal microchimerism has received a huge attention in the past, but data in PBC have been unsatisfactory especially if compared to other autoimmune diseases like systemic lupus erythematosus. Studies focused on genetic factors have generated more intriguing and robust data, reporting a few abnormalities on the X chromosome in PBC patients. However, these data are able to explain only a part of the phenotypic variability attributed to the genetic component, and most importantly, need to be validated in larger series. More recently, a novel mice model of PBC, characterised by a constitutive expression of Interferon-γ (IFN-γ), has been developed and it is notable for being the first one with female predominance. At the same time, there has been a wide interest in the role of microbiome in health and disease, as well as in epigenetics, which have tried to explain differences in biological phenotypes not covered by genetics. The aim of this review is to outline established knowledge on the topic and try to provide novel perspectives on the potential future applications of newer techniques addressing microbiome and epigenome, in order to further understand the biology of sex divergence in PBC.

https://ift.tt/2OO5j7P

Primary central nervous system vasculitis mimicking brain tumor: Comprehensive analysis of 13 cases from a single institutional cohort of 191 cases

Publication date: Available online 24 October 2018

Source: Journal of Autoimmunity

Author(s): Carlo Salvarani, Robert D. Brown, Teresa J.H. Christianson, John Huston, Jonathan M. Morris, Caterina Giannini, Gene G. Hunder

Abstract

Objective

To describe the clinical, laboratory, and imaging features and course of patients with primary central nervous system vasculitis (PCNSV) presenting with an intracranial tumor-like mass (TLM).

Methods

We retrospectively studied a cohort of 191 consecutive patients with PCNSV seen at the Mayo Clinic, Rochester, MN over a 35-year period (1982–2017). 13/191 patients presented with a TLM. We compared the findings in these 13 patients with those from the 178 without this presentation.

Results

In 13 of 191 (6.8%) patients with TLM the diagnosis of PCNSV was established by cerebral biopsy. Granulomatous vasculitis was found in 11/13 patients, accompanied by vascular deposits of β-amyloid peptide in 7. Compared to the 178 patients without TLM, the patients with TLM were more likely to be male (p = 0.04), and less likely to have a transient ischemic attack (p = 0.023), bilateral cerebral infarcts (p = 0.018), or vasculitic lesions on angiography (p = 0.045). They were more likely to have seizures (p = 0.022), gadolinium-enhanced lesions (p = 0.007), and amyloid angiopathy (p = 0.046). All 13 patients responded to therapy and 8/13 (61.5%) had a Rankin disability score of 0 at last visit. Overall, high disability scores (Rankin scores 4–6) at last follow-up were associated with increasing age (odds ratio, OR, 1.49) and cerebral infarction (OR, 3.47), but were less likely in patients with gadolinium-enhanced lesions (OR, 0.36) and amyloid angiopathy (OR, 0.21).

Conclusion

In PCNSV a TLM at presentation represents a definable subgroup of patients with a favourable treatment response.

https://ift.tt/2OSzQ4v

Discoid lupus erythematosus: Reflectance confocal microscopy features correlate with horizontal histopathological sections

Skin Research and Technology, EarlyView.


https://ift.tt/2OSNG7e

Dynamic thermal imaging on actinic keratosis patients: A preliminary study

Skin Research and Technology, EarlyView.


https://ift.tt/2O82cTn

Minimal erythema dose, minimal persistent pigment dose which model for whitening products evaluation is better?

Skin Research and Technology, EarlyView.


https://ift.tt/2ONqXZX

Ultrasound‐guided fine‐needle aspiration biopsy in skin lesions

Skin Research and Technology, EarlyView.


https://ift.tt/2O8rd0y

Age‐related changes in lip morphological and physiological characteristics in Korean women

Skin Research and Technology, EarlyView.


https://ift.tt/2OM99hO

Associations between whole tumor histogram analysis parameters derived from ADC maps and expression of EGFR, VEGF, Hif 1-alpha Her-2 and Histone 3 in uterine cervical cancer

Publication date: Available online 25 October 2018

Source: Magnetic Resonance Imaging

Author(s): Hans-Jonas Meyer, Peter Gundermann, Anne Kathrin Höhn, Gordian Hamerla, Alexey Surov

Abstract

Objective

Diffusion weighted imaging (DWI) can be quantified by apparent diffusion coefficient (ADC) and can predict tissue microstructure. The aim of the present study was to analyze possible associations between ADC histogram based parameters with different histopathological parameters in cervical squamous cell carcinoma.

Materials and methods

18 female patients (age range 32–79 years) with squamous cell cervical carcinoma were retrospectively enrolled. In all cases, pelvic MRI was performed with a DWI (b-values 0 and 1000 s/mm²). Histogram analysis was performed as a whole lesion measurement. Histopathological parameters included expression of EGFR, VEGF, Hif1-alpha, Her2 and Histone 3. Spearman's correlation coefficient was used to analyze associations between investigated parameters.

Results

Analyze of the investigated ADC histogram parameters showed a good interreader variability, ranging from 0.705 for entropy to 0.959 for ADCmedian. EGFR expression correlated statistically significant with several histogram parameters. The highest correlation was observed for p75 (p = −0.562, P = 0.015). There were several correlations with histone 3, the highest with p25 (p = −0.610, P = 0.007). None of the ADC related parameters correlated statistically significant with expression of VEGF, Hif1-alpha and Her2.

Conclusion

Histogram analysis showed a good interreader agreement. ADC histogram parameters might be able to reflect expression of EGFR and histone 3 in cervical squamous cell carcinomas, but not expression of VEGF, Hif1-alpha and Her2.

https://ift.tt/2ArAEo6

Scholar : These new articles for Theatre and Performance Design are available online

The online platform for Taylor & Francis Online content New for Theatre & Performance Design and online now on Taylor & Francis Online: Influential design Influential Design Leslie Travers Pages: 1-4 | DOI: 10.1080/23322551.2018.1534403 To update which email alerts you receive, manage your alerts within the My Account area. Unsubscribe from new content alerts for this journal (both new issue and latest article notifications) with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

The Use of Osteopathic Medical Manipulation to Decrease the Incidence and Severity of Post-Operative Sore Throat

Conditions:   Pharyngitis;   Dysphonia
Interventions:   Procedure: Osteopathic Manipulation Treatment;   Procedure: Sham
Sponsor:   Brooke Army Medical Center
Recruiting

https://ift.tt/2OP7SH2

Early Support in Primary Care for People Starting Treatment for Cancer

Conditions:   Cancer of Pancreas;   Cancer of Stomach;   Cancer of Esophagus
Intervention:   Other: Anticipatory care planning letter
Sponsors:   NHS Lothian;   NHS Fife
Recruiting

https://ift.tt/2RkJQ3x

Safety and Efficacy of Tipifarnib in Head and Neck Cancer With HRAS Mutations and Impact of HRAS on Response to Therapy

Conditions:   HRAS Gene Mutation;   HNSCC
Interventions:   Drug: Tipifarnib;   Device: HRAS Detection Assay
Sponsor:   Kura Oncology, Inc.
Not yet recruiting

https://ift.tt/2OONIgl

Enteral Omega 3 During Radiotherapy to Improve the Quality of Life and Functionality of Head and Neck Cancer Patients

Conditions:   Head and Neck Squamous Cell Carcinoma;   Quality of Life;   Radiotherapy; Complications
Interventions:   Dietary Supplement: Omega 3 Group;   Dietary Supplement: Placebo or Control Group
Sponsor:   Coordinación de Investigación en Salud, Mexico
Recruiting

https://ift.tt/2R9GP5G

Nal-iri/lv5-fu Versus Paclitaxel as Second Line Therapy in Patients With Metastatic Oesophageal Squamous Cell Carcinoma

Condition:   Squamous Cell Carcinoma
Interventions:   Drug: Onivyde;   Drug: Paclitaxel
Sponsors:   Federation Francophone de Cancerologie Digestive;   Shire
Not yet recruiting

https://ift.tt/2OO0cEF

Robot-assisted Approach to Cervical Cancer

Condition:   Cervical Cancer
Interventions:   Procedure: Abdominal radical hysterectomy;   Procedure: Robot-assisted radical hysterectomy;   Diagnostic Test: Sentinel lymph node biopsy
Sponsor:   Karolinska Institutet
Not yet recruiting

https://ift.tt/2RgxvgB

Acute Radiation Oral Mucositis in Nasopharyngeal Carcinoma(NPC) Patients Treated With Combined Radio-Chemotherapy

Condition:   Nasopharyngeal Carcinoma
Interventions:   Drug: Recombinant Human Interleukin-11;   Drug: Saline
Sponsor:   Zhejiang Cancer Hospital
Recruiting

https://ift.tt/2OMlBye

Scholar : These new articles for Environmental Forensics are available online

The online platform for Taylor & Francis Online content New for Environmental Forensics and online now on Taylor & Francis Online: Articles Heavy metal pollution and health risk assessment of road dust on selected highways in Düzce, Turkey F. Taşpınar & Z. Bozkurt Pages: 1-17 | DOI: 10.1080/15275922.2018.1519736 Hoping to have your article read by anyone, anywhere and at any time? Find out more about publishing open access with Ecosystem Health and Sustainability. To update which email alerts you receive, manage your alerts within the My Account area. Unsubscribe from new content alerts for this journal (both new issue and latest article notifications) with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : Acta Agriculturae Scandinavica, Section B — Soil & Plant Science, Volume 69, Issue 1, January 2019 is now available online on Taylor & Francis Online

The online platform for Taylor & Francis Online content Acta Agriculturae Scandinavica, Section B — Soil & Plant Science, Volume 69, Issue 1, January 2019 is now available online on Taylor & Francis Online. This new issue contains the following articles: Original Articles Adaptability of hull-less barley varieties to different cropping systems and climatic conditions Ievina Sturite, Arta Kronberga, Vija Strazdina, Aina Kokare, Mauritz Aassveen, Anne Kari Bergjord Olsen, Vita Sterna & Evita Straumite Pages: 1-11 | DOI: 10.1080/09064710.2018.1481995 Effects of crop-slope interaction on slope runoff and erosion in the Loess Plateau Bo Ma, Gang Liu, Fan Ma, Zhanbin Li & Faqi Wu Pages: 12-25 | DOI: 10.1080/09064710.2018.1488988 The quality of baby spinach as affected by developmental stage as well as postharvest storage conditions Ambani R. Mudau, Hintsa T. Araya & Fhatuwani N. Mudau Pages: 26-35 | DOI: 10.1080/09064710.2018.1492009 A 60-years old field experiment demonstrates the benefit of leys in the crop rotation | Zhenjiang Zhou, Cecilia Palmborg, Lars Ericson, Kent Dryler, Kim Lindgren, Göran Bergkvist & David Parsons Pages: 36-42 | DOI: 10.1080/09064710.2018.1492010 The impact of fire frequency on selected soil physical properties in a semi-arid savannah Thornveld M. I. Magomani & J. J. van Tol Pages: 43-51 | DOI: 10.1080/09064710.2018.1495253 Subsequent nitrogen utilisation and soil water distribution as affected by forage radish cover crop and nitrogen fertiliser in a corn silage production system Fang Wang, Ray R. Weil, Lei Han, Mingxin Zhang, Zhaojun Sun & Xiongxiong Nan Pages: 52-61 | DOI: 10.1080/09064710.2018.1498911 Evaluation of deep root phenotyping techniques in tube rhizotrons Si Chen, Eric van der Graaff, Nanna Karkov Ytting & Kristian Thorup-Kristensen Pages: 62-74 | DOI: 10.1080/09064710.2018.1500635 Soil tillage methods by years interaction for harvest index of maize (Zea mays L.) using additive main effects and multiplicative interaction model Jan Bocianowski, Kamila Nowosad & Piotr Szulc Pages: 75-81 | DOI: 10.1080/09064710.2018.1502343 Challenges to the exploitation of host plant resistance for Striga management in cereals and legumes by farmers in sub-Saharan Africa: a review Ronald Mandumbu, Charles Mutengwa, Stanford Mabasa & Eddie Mwenje Pages: 82-88 | DOI: 10.1080/09064710.2018.1494302 The effect of a mixture of two plant growth-promoting bacteria from Argentina on the yield of potato, and occurrence of primary potato diseases and pest – short communication Stanislav Trdan, Filip Vučajnk, Tanja Bohinc & Matej Vidrih Pages: 89-94 | DOI: 10.1080/09064710.2018.1492628 Hoping to have your article read by anyone, anywhere and at any time? Find out more about publishing open access with Ecosystem Health and Sustainability. To update which email alerts you receive, manage your alerts within the My Account area. Unsubscribe from new content alerts for this journal (both new issue and latest article notifications) with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : Journal of Tourism and Cultural Change, Volume 16, Issue 5, November 2018 is now available online on Taylor & Francis Online

The online platform for Taylor & Francis Online content Journal of Tourism and Cultural Change, Volume 16, Issue 5, November 2018 is now available online on Taylor & Francis Online. This new issue contains the following articles: Articles Resident perception of dark tourism impact: the case of Beichuan County, China Jinwei Wang & Xianrong Luo Pages: 463-481 | DOI: 10.1080/14766825.2017.1345918 Embedded and exposed: exploring the lived experiences of African American tourists Charis N. Tucker & Cynthia S. Deale Pages: 482-500 | DOI: 10.1080/14766825.2018.1445745 From ideological space to recreational tourism: the Israeli forest Kobi Cohen-Hattab, Alon Gelbman & Noam Shoval Pages: 501-520 | DOI: 10.1080/14766825.2017.1408637 Tourism-induced mobilities and transformation of indigenous cultures: where is the Vedda community in Sri Lanka heading to? Ruwan Ranasinghe & Li Cheng Pages: 521-538 | DOI: 10.1080/14766825.2017.1393081 Factors influencing cultural event tourism in Nelson Mandela Bay, South Africa Sasha Boucher, Margaret Cullen & Andre Calitz Pages: 539-551 | DOI: 10.1080/14766825.2017.1420070 From fighting against death to commemorating the dead at Tangshan Earthquake heritage sites Shengrong Chen & Honggang Xu Pages: 552-573 | DOI: 10.1080/14766825.2017.1359281 Book Reviews Holidays in the danger zone: entanglements of war and tourism Tina Šegota Pages: 574-576 | DOI: 10.1080/14766825.2018.1530879 Tourism in the Arab world: an industry perspective Suleiman Farajat Pages: 576-579 | DOI: 10.1080/14766825.2018.1530876 Tourism marketing for developing countries: battling stereotypes and crises in Asia, Africa and the Middle East Eduardo Manuel Machado de Moraes Sarmento Ferreira Pages: 579-581 | DOI: 10.1080/14766825.2018.1530878 To update which email alerts you receive, manage your alerts within the My Account area. Unsubscribe from new content alerts for this journal (both new issue and latest article notifications) with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : Shakespeare, Volume 14, Issue 4, December 2018 is now available online on Taylor & Francis Online

The online platform for Taylor & Francis Online content Shakespeare, Volume 14, Issue 4, December 2018 is now available online on Taylor & Francis Online. This new issue contains the following articles: Criticism What's So Funny 'Bout, Peace, Love, and Shakespeare?: A Peace Studies Approach to As You Like It John S. Garrison & Kyle Pivetti Pages: 298-311 | DOI: 10.1080/17450918.2016.1253603 The Unprodigal Prince? Defining Prodigality in the Henry IVs Ezra Horbury Pages: 312-325 | DOI: 10.1080/17450918.2017.1322132 "I loved my books": Shakespeare and the Modernity of Loving Literature Annemie Brams & Raphaël Ingelbien Pages: 326-340 | DOI: 10.1080/17450918.2017.1291535 "To be, or not to be": Shakespeare Against Philosophy Jeffrey R. Wilson Pages: 341-359 | DOI: 10.1080/17450918.2017.1343376 Black But Yet Fair: The Topos of the Black Beloved from Song of Songs in Shakespeare's Work Camilla Caporicci Pages: 360-373 | DOI: 10.1080/17450918.2017.1354061 Performance Beyond Indigenisation: Hamlet, Haider, and the Pain of the Kashmiri People Sandra Young Pages: 374-389 | DOI: 10.1080/17450918.2017.1351486 Goodbye Wave: Trevor Nunn's Twelfth Night – A Maritime Valediction Peter J. Smith Pages: 390-398 | DOI: 10.1080/17450918.2017.1381641 "What's in a name?": Romeo and Juliet and the Cibber Brand Elaine M. McGirr Pages: 399-412 | DOI: 10.1080/17450918.2017.1406983 Review of Shakespeare's Macbeth (directed by Adele Thomas for Tobacco Factory Theatres) at the Tobacco Factory, Bristol, 26 February 2018 Emily Derbyshire Pages: 413-415 | DOI: 10.1080/17450918.2018.1518338 Review of Webster's The Duchess of Malfi (directed by Maria Aberg for the Royal Shakespeare Company) at the Swan Theatre, Stratford-upon-Avon, 13 March 2018, and Lyly's The Woman in the Moon (directed by Perry Mills for Edward's Boys) at Levi Fox Hall, King Edward VI School, 11 March 2018 Joseph F. Stephenson Pages: 416-420 | DOI: 10.1080/17450918.2018.1467483 Review of Shakespeare's Much Ado About Nothing (directed by Simon Dormandy for Antic Face and Granville & Parham Productions) at the Rose Theatre, Kingston upon Thames, 21 April 2018 Ben Haworth Pages: 421-423 | DOI: 10.1080/17450918.2018.1482951 Review of Shakespeare's Macbeth (directed by Rufus Norris) at the Olivier Theatre, National Theatre, London, 26 April 2018 Sally Barnden Pages: 424-426 | DOI: 10.1080/17450918.2018.1482950 Review of Shakespeare's Romeo and Juliet (directed by Erica Whyman for the Royal Shakespeare Company) at the Royal Shakespeare Theatre, Stratford-upon-Avon, 8 May 2018 Diane Lowman Pages: 427-429 | DOI: 10.1080/17450918.2018.1482953 To update which email alerts you receive, manage your alerts within the My Account area. Unsubscribe from new content alerts for this journal (both new issue and latest article notifications) with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Association of Multiple Sclerosis with Psoriasis: A Systematic Review and Meta-Analysis of Observational Studies

Abstract

Background

Previous studies have reported the occurrence of psoriasis together with multiple sclerosis (MS). Although similar predisposing genes and pathomechanisms have been hypothesized, the relationship between the two remains obscure.

Objective

The aim of this systematic review and meta-analysis was to investigate the association between psoriasis and MS.

Methods

We searched MEDLINE, Embase, and CENTRAL in July 2018 for case–control, cross-sectional, or cohort studies that examined either the odds or risk of psoriasis in subjects with multiple sclerosis. The risk of bias of included studies was assessed using the Newcastle–Ottawa Scale. A random-effects model meta-analysis was used to calculate the odds ratio (OR) for case–control/cross-sectional studies and hazard ratio (HR) for cohort studies.

Results

We included 10 publications that reported a total of 11 studies (5 case–control, 4 cross-sectional and 2 cohort studies). The case–control and cross-sectional studies included 18,456 MS patients and 870,149 controls, while the two cohort studies involved 25,187 MS patients and 227,225 controls in total. Three studies were rated with a high risk of bias in comparability, non-response rate, and selection of controls. MS was associated with increased odds (OR 1.29; 95% confidence interval [CI] 1.14–1.45) and risk for psoriasis (HR 1.92; 95% CI 1.32–2.80).

Conclusion

Patients with MS display both increased prevalence and incidence of psoriasis.

https://ift.tt/2PReGAh

Cutaneous Adverse Effects of Diabetes Mellitus Medications and Medical Devices: A Review

Abstract

Diabetes mellitus is one of the most prevalent chronic diseases in the USA. If uncontrolled, diabetes can lead to devastating complications. Diabetes medications and medical devices largely contribute to the significant financial expense that the disease inflicts on affected individuals and society. Alongside significant economic burden, there are numerous cutaneous adverse effects associated with diabetes medications and medical devices. Despite the large and increasing number of individuals living with diabetes and the wide use of the related medications and medical devices, there is limited literature that comprehensively documents their cutaneous adverse effects. These cutaneous adverse effects are significant as they can worsen glycemic control, increase disease distress, and may increase risk of associated complications. Thus, it is important that providers can recognize these cutaneous adverse effects, identify the culprit agents, and can properly manage them. In this article, we provide a critical review of the cutaneous adverse effects of medications and devices used in the management of diabetes and provide insight into risk factors and prevention and an overview of therapeutic management. An emphasis is placed on clinical recognition and treatment for use of the medical providers who, regardless of practice setting, will treat patients with diabetes.

https://ift.tt/2ArdVZg

A Young Male with Parafibromin-Deficient Parathyroid Carcinoma Due to a Rare Germline HRPT2/CDC73 Mutation

Abstract

Hyperparathyroidism, commonly observed in asymptomatic middle-aged women, with mild hypercalcemia, is usually caused by a benign adenoma. Some cases present with more severe manifestation and greater hypercalcemia. Within this spectrum, several familial/genetic associations have been discovered. While the majority are caused by benign disease, adenomas, or hyperplasia, a small proportion (< 1%) are associated with malignant tumors and present with more severe symptoms. Although usually sporadic, recent reports document various gene mutations that strongly predispose to the development of parathyroid carcinoma. An increasing number of cases of hyperparathyroidism, benign or malignant, require and benefit from genetic analysis. We describe a 25-year-old male with hyperparathyroidism presenting with a pathological fracture, brown tumors, hypercalcemia, and markedly elevated parathyroid hormone levels. There was no family history of hyperparathyroidism or jaw tumors. Surgical removal revealed a single large tumor confirmed to be malignant. Immunohistochemical analysis revealed the absence of parafibromin and decreased APC (adenomatosis polyposis coli) expression. Genetic analysis revealed a rare germline nonsense mutation (R76X) in the parafibromin gene, HRPT2/CDC73. Parathyroid carcinoma should be suspected as a cause of hyperparathyroidism when clinical manifestations are severe, particularly in young individuals, < 59 years. Immunohistochemistry may lead to suspicion for a germline mutation as a significant contributor despite absence of a family history. The discovery of a germline mutation in parathyroid carcinoma alters the clinical management of the index case and that of family members. Long-term follow-up studies of such patients are necessary to develop evidence-based clinical guidelines.

https://ift.tt/2PgswiL

Scholar : Decannulation - νέα αποτελέσματα

Standards for pediatric FAE and sedation have been published separately, although standards for sedation specific to FAE in children have not.

P Assessment - The Pediatric Procedural Sedation Handbook, 2018

INTERFACILITY VENTILATOR MANAGEMENT

C COMPLAINT - Acute Care Casebook, 2018

… She has a past medical history of moderate chronic obstructive pulmonary
disease, moderate persistent asthma, hypertension, type 2 diabetes, super
morbid obesity, previous tracheostomy with successful wean and …

[PDF] Comparison of dysphagia-related tracheostomy management by Dutch SLTs in hospitals, rehabilitation centers and nursing homes

I Adbegovic, P Stekkinger, AW van Gerwen, JG Kalf

… Introduction • When decannulation during hospital stay is not possible (yet), management
continues in a rehabilitation center … We sent questionnaires about dysphagia management
and involvement in decannulation to SLTs of 92 ICUs, 16 RCs and 29 NHs1,2,3 …

Surgical therapy for heart failure

S Westaby - Core Concepts in Cardiac Surgery, 2018

[PDF] CRITÉRIOS PARA DECANULAÇÃO EFICAZ: UMA REVISÃO DE LITERATURA

EL de Oliveira, CR Rocha, MR Vanvos-sen - Cep

… CRITÉRIOS PARA DECANULAÇÃO EFICAZ: UMA REVISÃO DE LITERATURA
Decannulation criteria more efficient: a literature review … The term decannulation is used
to designate the removal of the artificial airway from tracheostomized patients …

[HTML] Pulmonary Thromboendarterectomy for Chronic Thromboembolic Pulmonary Hypertension

O Orlov

… The Impella device was removed on postoperative day 10. The patient required a
percutaneous tracheostomy due to ventilator-dependent respiratory failure. The patient
was discharged to a rehabilitation facility where she successfully underwent decannulation …

 

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