AbstractImmune checkpoint inhibitors (ICIs) initiate antitumor immunity by blocking the action of immune inhibitor‐signaled cytotoxic proteins, such as cytotoxic T‐lymphocyte‐associated protein 4, programmed cell death protein 1, and programmed cell death ligand 1. However, in rare cases (∼1%–12% of patients), ICI treatment causes neurologic immune‐related adverse events (irAEs). These include, but are not limited to, headache, encephalitis, neuropathies, myasthenia gravis, and myositis. The symptoms associated with irAEs can range from mild (grade 1–2) to severe (grade 3–4); however, they are often challenging to diagnose because they may present as generalized symptoms, such as fatigue and weakness, that can also be caused by the cancer itself. Here, we present an illustrative case of a 67‐year‐old woman who presented with signs of a neurologic irAE, including progressive dysphagia and weakness leading to falls, which started during treatment with pembrolizumab and worsened following initiation of ipilimumab. Following neurological and pathological evaluation, she was diagnosed with myositis. She was treated with steroids and improved rapidly. In this article, we review previous literature to provide guidance to frequently asked questions concerning the diagnosis and management of neurologic irAEs in patients with advanced cancer. With prompt and effective treatment, most patients will achieve a complete recovery.Key Points. Neurologic immune‐related adverse events (irAEs) affect approximately 1% of patients treated with immune checkpoint inhibitor (ICI) monotherapy and 2%‐3% treated with combination therapy. These irAEs can affect any portion of the nervous system, although peripheral nerve system manifestations are most common. Overlap syndromes with multiple neurologic irAEs or other affected organ systems frequently exist.Diagnosis of neurologic irAEs can be challenging. Routine testing may be unremarkable and symptoms frequently mimic those from cancer or side effects of other therapies. Optimal management is currently unknown. A systematic, highly coordinated, and multidisciplinary approach is critical.Outcomes from neurologic irAEs are typically favorable with the current practice of holding the ICI and starting corticosteroids. Some patients are even successfully retreated with an ICI. A subset of patients, however, have a fulminant and potentially fatal course.Improved risk assessments and targeted therapies are needed.
https://ift.tt/2PZwCwz
Τρίτη 27 Νοεμβρίου 2018
Diagnosis and Management of Immune Checkpoint Inhibitor‐Associated Neurologic Toxicity: Illustrative Case and Review of the Literature
High‐Grade Gastrointestinal Neuroendocrine Carcinoma Management and Outcomes: A National Cancer Database Study
AbstractBackground.High‐grade neuroendocrine carcinomas are rare in the gastrointestinal tract. However, treatment patterns and outcomes have not been well described.Subjects, Materials, and Methods.The National Cancer Database was analyzed. The primary objective was to describe the clinical outcomes and identify prognostic factors. Univariate and multivariate analyses were done to identify factors associated with patient outcome.Results.A total of 1,861 patients were identified between 2004 and 2013. The mean age was 63 years (standard deviation ±13). The majority of the patients (78.1%) were non‐Hispanic whites. The most common primary sites were pancreas (pancreatic neuroendocrine tumor [PNET] = 19.4%), large intestine (18.1%), esophagus (17.8%), and rectum (15.5%). Stage at presentation was I (6.6%), II (10.5%), III (18%) and IV (64.6%). Only 1.6% of the patients had brain metastases. Surgical resection was the primary therapy in 27.9%, and their median overall survival (OS) was 13.3 months. Patients treated with palliative chemotherapy had a median OS of 11.2 months, compared with 1.7 months for untreated patients. The median OS for high‐grade PNET was 6 months, compared with 9.9 months for other high‐grade gastrointestinal neuroendocrine carcinomas (HG GI NEC). On univariable analysis, age < 65 years (hazard ratio [HR] 0.72; 0.66–0.8; p < .001) and treatment at an academic center (HR 0.88; 0.79–0.99; p < .034) were associated with improved survival. Multivariable analysis confirmed prognostic advantage of treatment at an academic center.Conclusion.This is the largest series of HG GI NEC. Most patients present with metastatic disease, and overall survival remains poor. Treatment at an academic center, younger age, and use of chemotherapy were associated with improved survival. Multiagent chemotherapy was found to be associated with superior survival compared with single‐agent chemotherapy, which was superior to no chemotherapy. Temporal sequences of chemotherapy, surgery, and radiation administration were not found to be associated with survival differences on multivariable analysis.Implications for Practice.Management of patients with high‐grade gastrointestinal neuroendocrine carcinomas (HG GI NEC) is based on experience with small‐cell lung cancer. In this retrospective review, most patients had advanced disease and pancreatic primary had worse outcomes. Treatment at an academic center, younger age, and use of chemotherapy are associated with improved survival. Patients with early‐stage disease treated with resection alone had inferior outcomes compared with patients who received neoadjuvant or adjuvant therapy, suggesting that micrometastases contribute to poor surgical outcomes. The relatively high proportion of positive surgical margin favors downstaging with neoadjuvant therapy to improve resection and lower the risk of systemic recurrence.
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Missing canines: a novel aetiology
Abstract
Infant oral mutilation is the practice of removing developing tooth germs, commonly the mandibular canine, in infants up to the age of one year. Subsequent complications include missing, impacted or hypoplastic permanent anterior and canine teeth. We report on a case of bilaterally missing lower canines thought to be due to infant oral mutilation. It is important that general dental practitioners are aware of this practice and resulting complications when treating families from sub‐Saharan East Africa.
This article is protected by copyright. All rights reserved.
https://ift.tt/2RkjgIa
Trigger finger in a hereditary multiple exostoses disease: A unique case report
Abstract
Trigger finger is one of the most common upper extremity problems seen by hand surgeons. Lesions occupying space in the tendon bed can prevent tendon gliding. We describe a unique case of trigger finger in a patient known for a hereditary multiple exostoses disease where an exostosis in the tendon bed constricted the tendon sheath, leading to triggering and locking. Open surgical treatment was performed by removing of the exostosis which relieved the problem.
Level of Evidence: Level V, therapeutic study.
https://ift.tt/2TPDNWv
Higher circulating androgens and higher physical activity levels are associated with less central adiposity and lower risk of cardiovascular death in older men
Abstract
Objective
Low endogenous sex hormones and low physical activity (PA) levels have been associated with CVD risk. Whether these interact to influence CVD outcomes remains unclear. We assessed whether sex hormone concentrations and PA were additively associated with lower central adiposity and CVD risk.
Patients
3,351 community‐dwelling men, mean age 77 years.
Measurements
Baseline testosterone (T), dihydrotestosterone (DHT) and estradiol (E2) were assayed. Levels of PA were ascertained by questionnaire. Men were stratified using median splits into high hormone+high PA (H/H), high hormone+low PA (H/L); low hormone+high PA (L/H) and low hormone+low PA (L/L) groups.
Results
865 CVD events and 499 CVD deaths occurred during 10‐year mean follow‐up. Men with higher T, DHT or SHBG and higher PA had the lowest BMI, waist circumference and risk of metabolic syndrome. Men with higher T had the lowest risk of incident CVD events, irrespective of PA level. Men with higher T or DHT and higher PA had the lowest risk of dying from CVD (e.g. hazard ratios for T/PA H/H 0.76 p=0.031; H/L 0.85 p=0.222; L/H 0.80 p=0.075; L/L 1.00).
Conclusion
Higher circulating androgens and higher PA were associated with less central adiposity at baseline and fewer CVD deaths during follow‐up. These findings are consistent with a potential additive effect of androgens and PA on cardiometabolic outcomes in older men.
This article is protected by copyright. All rights reserved.
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Estrogen associated with UVB irradiation recapitulates the specific melanosome distribution observed in Caucasoid Melasma
Abstract
Melasma is characterized by light to dark brown macules that usually occur on the face. Melasma occurs in 10‐15% of pregnant women and in 10‐25% of women taking oral contraceptives. Fertile women are most likely to develop melasma. Histological examination of melasma lesional skin revealed mainly pigmentary disorders with an increased melanin deposition in all layers of the epidermis including the horny layer and a frequent presence of melanophages in the dermis. On the other hand in the upper dermis, a disruption of the basement membrane in 3.9% of cases, an abundance of elastotic material and an increased number of blood vessels and mast cells have been reported in melasma.
This article is protected by copyright. All rights reserved.
https://ift.tt/2KFvR6g
Glucocorticoid insensitivity by staphylococcal enterotoxin B in keratinocytes of allergic dermatitis is associated with impaired nuclear translocation of the Glucocorticoid Receptor α
Publication date: Available online 26 November 2018
Source: Journal of Dermatological Science
Author(s): Ke Huang, Lei Ran, Wei Wang, Rong Zhou, Xiaowei Cai, Ran Li, Yuanchao Li, Chunli Zhou, Wei He, Rupeng Wang
Abstract
Background
staphylococcal enterotoxin plays an important role in patients with glucocorticoid (GC)-resistant atopic dermatitis (AD), but the exact mechanism is not fully understood.
Objective
The aim of this study was to investigate the mechanisms underlying the ability of staphylococcal enterotoxin B (SEB) to induce steroid insensitivity through impaired nuclear translocation of GRα in keratinocytes.
Methods
The steroid-resistant AD induced by SEB was assessed by analyzing dermatitis score, dermal thickness, scratching behavior, infiltrating cells/HPF, levels of SEB-specific IgE and IgG2a antibody. In addition, dexamethasone (DEX)-induced GRα nuclear translocation and keratinocyte-derived cytokines and chemokines were analyzed in the lesional keratinocytes of AD and in HaCaT cells. Furthermore, the expressions of immunophilins FKBP51, FKBP52 and HSP90 responsive to GC in HaCaT cells were determined in the presence of SEB.
Results
SEB dose-dependently diminished the inhibitory effect of DEX on dermatitis score, dermal thickness, scratching behavior, infiltrating cells/HPF, keratinocyte-derived cytokines and chemokines such as RANTES, MCP-1, TSLP and GM-CSF. In vivo and in vitro data showed that in the presence of DEX, SEB dose-dependently caused a marked decrease of GRα nuclear translocation in lesional keratinocytes of AD and in HaCaT cells. Importantly, in the presence of DEX, SEB increased the expression of FKBP51 and the product of keratinocyte-derived cytokines and chemokines in HaCaT cells.
Conclusion
These results demonstrate that GC insensitivity by SEB in keratinocytes of AD is associated with impaired nuclear translocation of the GRα. Increased DEX-induced FKBP51 by SEB may contribute to accumulation of the GRα in cytoplasm of keratinocytes.
https://ift.tt/2TQnJUD
TRPV1 mediates inflammation and hyperplasia in imiquimod (IMQ)-induced psoriasiform dermatitis (PsD) in mice
Publication date: Available online 26 November 2018
Source: Journal of Dermatological Science
Author(s): Yan Zhou, Taylor Follansbee, Xuesong Wu, Dan Han, Sebastian Yu, Dan T. Domocos, Zhenrui Shi, Mirela Carstens, Earl Carstens, Samuel T. Hwang
Abstract
Background
Transient Receptor Potential Vanilloid 1 (TRPV1) is known to mediate itch and neurogenic inflammation, but the role of TRPV1 in psoriasiform dermal inflammation is poorly understood.
Objective
To investigate the function of TRPV1 in imiquimod (IMQ)-induced psoriasiform dermatitis (PsD) in mice.
Methods
Following daily treatment of topical IMQ cream for consecutive 5 days in C57BL/6 wide-type (WT) and TRPV1 gene knockout (KO) mice, we assessed the psoriasis severity index (PSI) scores, transepidermal water loss (TEWL), dermal inflammatory infiltrates, as well as gene expression levels for psoriasis related genes in mouse skin lesions.
Results
Compared with WT mice, the clinical and TEWL scores, the extent of skin hyperplasia, the area of Munro microabscesses (MM) and angiogenesis of psoriasis were all significantly decreased in TRPV1 KO mice triggered with IMQ, suggesting a reduction in skin inflammation and barrier defects. In addition, the infiltration of CD45+ leukocytes, mast cells as well as CD3 + T cells was all reduced in the IMQ-treated skin of TRPV1 KO mice. Quantitative Real-time PCR (RT-qPCR) revealed that expression levels of IL-1β, IL-6, IL-23, S100A8 were decreased while IL-10 was increased in TRPV1 KO mice.
Conclusions
In summary, key markers of psoriatic inflammation and epidermal hyperplasia are reduced in TRPV1 KO mice, indicating the involvement of TRPV1 in the psoriasiform inflammation and suggesting its potential as a therapeutic target.
https://ift.tt/2AtUVbB
7-Tesla MRI of the brain in a research subject with bilateral, total knee replacement implants: Case report and proposed safety guidelines
Publication date: Available online 27 November 2018
Source: Magnetic Resonance Imaging
Author(s): Giuseppe Barisano, Bozena Culo, Frank G. Shellock, Farshid Sepehrband, Katherin Martin, Mary Stevens, Danny J. Wang, Arthur W. Toga, Meng Law
Abstract
Recently, the first 7-T MR system was approved for clinical use in the United States. Unfortunately, relatively few metallic implants have undergone testing to determine if they are acceptable or pose hazards to research subjects and patients at this ultra-high-field strength. Therefore, in lieu of not performing a research or clinical MRI exam at 7-T, the supervising physician may make a decision to scan the individual with an untested metallic implant based on an analysis of the risks vs. the benefits. We present a case report of a research subject with bilateral, total knee replacement implants that safely underwent MRI of the brain at 7-T and provide guidelines for healthcare professionals to follow in order to ensure safety in research subjects or patients with metallic implants referred for 7-T scans.
https://ift.tt/2TPMKyX
Scholar : ΣΤΟΜΑΤΙΤΙΣ - νέα αποτελέσματ
Phase I Trial of Systemic Administration of Vesicular Stomatitis Virus Genetically Engineered to Express NIS and Human Interferon, in Patients with Relapsed or …
oncolytic virus, MMV-NIS. Preexisting immunity against measles made use of that
virus unsatisfactory. The Indiana strain of Vesicular Stomatitis Viruses (VSV) are …
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Methotrexate-Associated Toxicity in Children with Down Syndrome and Acute Lymphoblastic Leukemia during Consolidation Therapy with High Dose Methotrexate …
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[PDF] СТОМАТИТ СОБАК И КОШЕК
DOGS AND CATS Abstract: The article discusses the main types of pathologies of the
oral cavity in dogs in the city of Tyumen. Some etiological features of stomatitis are revealed …
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[PDF] ASSOCIATION OF COMPLEMENTFACTOR H GENE (CFH) SINGLE NUCLEOTIDE POLYMORPHISM WITH RECURRENT APHTHUS STOMATITIS
affecting oral mucosa that lead to mucosal ulceration. The causes are unclear, but
dysregulation of the immune response has been proposed to be implicated in the …
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Characterization of oral mucosa lesions and prevalence of yeasts in diabetic patients: A comparative study
described in Table 4. Development of coated tongue and leukoedema was
significantly high in diabetic group individuals who had significantly more …
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[HTML] ТАБЛЕТКА КАК ЛЕКАРСТВЕННАЯ ФОРМА ЛЕКАРСТВЕННЫХ СРЕДСТВ, ПРЕДНАЗНАЧЕННАЯ ДЛЯ ВВЕДЕНИЯ ИХ ВНУТРЬ: ДОСТОИНСТВА И …
excessively high physical-chemical activity, which can cause caries, stomatitis, gastritis
and stomach ulcers. The ways to increase the safety of tablets and their intake is indicated …
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[PDF] A phase IIIb trial of afatinib in EG-FRm+ NSCLC: analysis of outcomes in patients with brain metastases or dose reductions
Stomatitis* 15 (3.1) 22 (4.6) Paronychia* 12 (2.5) 13 (2.7) Page 10 … Diarrhea
26.1 95.8 4.2 51.3 Rash/acne† 24.4 68.9 10.9 58.0 Stomatitis† 10.9 63.0 …
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Durable Responses Observed with JAK Inhibition in T-Cell Lymphomas
Types; blood hubs™. All Issues; Abstracts: 2018; 2017; 2016; All Abstracts. Video Library.
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A Phase I/II, Open-Label, Multicentre 2-Part Study to Assess the Safety, Tolerability, Pharmacokinetics, and Efficacy of AZD2811 Nanoparticle As Monotherapy or in …
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Phase I Study of Yttrium-90 Labeled ANTI-CD25 (aTac) Monoclonal Antibody PLUS BEAM for Autologous Hematopoietic CELL Transplantation (AHCT) in Patients …
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Scholar : ΠΑΛΙΝΔΡΟΜΗΣΗ - νέα αποτελέσμ
Χαρακτηριστικά των χαλαζοκαταιγίδων στην περιοχή της Θεσσαλίας.= Hailstorms characteristics in the region of Thessaly.
παλινδρόμηση με συντελεστές βαρύτητας, ενώ για τον δείκτη εφαρμόζεται επιπλέον
και η πολλαπλή γραμμική παλινδρόμηση με συντελεστές βαρύτητας …
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Διερεύνηση της επίδρασης της συναισθηματικής νοημοσύνης, του άγχους και του θυμού στην υγεία και στη σχετιζόμενη με την υγεία ποιότητα ζωής των εφήβων …
ανεξάρτητες μεταβλητές προέκυψαν σημαντικές στη διμεταβλητή ανάλυση, εφαρμόστηκε
πολλαπλή γραμμική παλινδρόμηση (multivariate linear regression) …
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[PDF] Διερεύνηση των προσδιοριστικών παραγόντων της ικανοποίησης γονέων ασθενών στις παιδοχειρουργικές κλινικές
Διερεύνηση των προσδιοριστικών παραγόντων της ικανοποίησης γονέων ασθενών στις
παιδοχειρουργικές κλινικές ΟΝΟΜΑΤΕΠΩΝΥΜΟ: ΤΣΙΑΠΡΑΖΗ ΘΕΟΔΩΡΑ …
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Scholar : intitle:Bioprinting - νέα αποτελέσματα
Development of a hybrid alginate-ECM hydrogel as a potential bioink for 3D bioprinting
disease, but tissue shortage remains a problem. Generating lung tissue ex vivo could
overcome tissue shortages. Both synthetic and biologic scaffolds have been …
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Author Correction: Magnetic Resonance Imaging for tracking cellular patterns obtained by Laser-Assisted Bioprinting
the author Emeline Julie Ribot, which was incorrectly given as Emeline Ribot. This
has now been corrected in the PDF and HTML versions of the Article, and in the …
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Late Breaking Abstract-Lung extracellular matrix hydrogel as bioink for 3D bioprinting: a model for studying cell-matrix crosstalk
scaffolds for studying cell-matrix crosstalk in realistic 3D environments. They can be
used as bioinks to build 3D constructs providing physiological, molecular and …
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Nanopatterning and Bioprinting in Orthopedic Surgery
door for more sophisticated orthopedic implants. However, regardless of design
architecture, bacterial infection of musculoskeletal implants will remains a major …
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Scholar : Myringotomy and tubes - νέα αποτελέσματα
PLASMINOGEN DOSAGE REGIMEN FOR WOUND HEALING
pressure-equalizing tubes (ventilating tubes) are placed, the tympanic
membrane perforation purposely is held open. Failure of surgically created …
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Conductive hearing loss with a "dry middle ear cleft"–a comprehensive pictorial review with CT
including prior myringotomy or tympanostomy tube insertion [[3], [4 …
MawDevelopment of tympanosclerosis in children with otitis media with …
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Особенности микроциркуляции в слизистой оболочке носа у детей с гипертрофией аденоидов и экссудативным средним отитом
care in children undergoing myringotomy and tube placement: current perspectives. Local
and regional anesthesia, 10, 41. Pavlenko, VA, Mel'nikova, IM, Mizernitskiy, Yu.L. (2015) …
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Scholar : ΑΠΟΚΑΤΑΣΤΑΣΗ - νέα αποτελέσμ
Οριοθέτηση κατάλληλων θέσεων για ΧΥΤΑ σε επιλεγμένη περιοχή του Νόμου Χαλκιδικής με τη χρήση των Γεωγραφικών Συστημάτων Πληροφοριών/GIS …
χρόνια, εφόσον έχει συμπληρωθεί ο κύκλος ζωής τους, ανακάμπτεται η λειτουργία
τους και ξεκινάει η αποκατάσταση τους. Οι ΧΥΤΑ λειτουργούν …
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Τεχνικογεωλογική αξιολόγηση για του έλεγχο ευστάθειας κατολίσθησης στο Ανήλιο Ιωαννίνων.= Engeering geological assessment for the slope stability of landslides in …
δυσάρεστες κοινωνικο-οικονομικές επιπτώσεις, η αποκατάσταση των οποίων μπορεί
να αποβεί εξαιρετικά δαπανηρή. Τα αίτια των κατολισθητικών …
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Τα βιομηχανικά ορυκτά και πετρώματα της Ανατολικής Μακεδονίας με έμφαση στην ΠΕ Δράμας.= The industrial minerals and racks of eastern Macedonia with …
Χατζημανώλη Ε., 2016. Γνώσεις και στάσεις της τοπικής κοινωνίας του Βώλακα
Νομού Δράμας και η περιβαλλοντική αποκατάσταση των χώρων εξόρυξης …
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Μελέτη της διάβρωσης των ασβεστολίθων από τα αρχαία λατομεία προσκυνητών στην περιοχή Μαρώνειας-Ξυλάγανης.= Study of the limestone erosion at the …
μνημείων του αρχαιολογικού χώρου της Ελευσίνας και προτάσεις για την
αποκατάστασή τους. Μεταπτυχιακή εργασία, Τμήμα Γεωλογίας …
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[PDF] Tο Ελληνικό Ελεγκτικό Συνέδριο και ο προληπτικός και κατασταλτικός έλεγχος στους ΟΤΑ Α΄ Βαθμού
Διαπιστωθέν Έλλειμμα ή Απώλεια 2.5.3 Αποκατάσταση του ελλείμματος -
καταλογιστική πράξη 3. Κεφάλαιο Τρίτο: ΜΕΘΟΔΟΛΟΓ Α ΕΡΕΥΝΑΣ 3.1 …
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Ορυκτολογική-γεωχημική μελέτη των υλικών του παλαιού χώρου απόθεσης στην ευρύτερη περιοχή της πλατείας+ 53, Στρατώνι Χαλκιδικής
–Μεταλλουργικές Εγκαταστάσεις Μεταλλείων Κασσάνδρας», β) « Απομάκρυνση,
Καθαρισμός και Αποκατάσταση Χώρου Απόθεσης Παλαιών Τελμάτων …
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[PDF] Εφαρμογή κανόνων εταιρικής διακυβέρνησης σε οργανισμούς και ΔΕΚΟ
Διακυβέρνησης σε Οργανισμούς και ΔΕΚΟ» ΣΥΝΤΑΞΗ - ΕΠΙΜΕΛΕΙΑ: Άγγελος Μιχαήλ
Κ. Μιχαλόπουλος ΕΠΙΒΛΕΠΩΝ ΚΑΘΗΓΗΤΗΣ: Νικόλαος Β. Τσαγκαράκης Πειραιάς, 2018 …
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[PDF] Σύμβαση χρονοναύλωσης οχηματαγωγού πλοίου
ΕΡΓΑΣΙΑ ΣΤΗ ΔΙΟΙΚΗΣΗ ΕΡΓΩΝ ΚΑΙ ΑΝΑΠΤΥΞΗ ΠΡΟΪΟΝΤΩΝ από ΤΟ ΠΑΝΕΠΙΣΤΗΜΙΟ
ΠΕΙΡΑΙΩΣ ΓΙΩΡΓΟΣ Δ. ΤΣΑΒΟΣ ΤΜΗΜΑ ΒΙΟΜΗΧΑΝΙΚΗΣ ΔΙΟΚΗΣΗΣ ΚΑΙ ΤΕΧΝΟΛΟΓΙΑΣ …
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[PDF] Διάχυτο σχολείο κριτικής παιδαγωγικής στην Ακαδημεία Πλάτωνος
ευχαριστώ για όλα τη Βάσω, τον Αρη και το Στέφανο, την Κατερίνα, την Ασημίνα, τη Μυρσίνη,
το Στάθη, το Μπάμπη, την Ισαβέλλα, το Δήμο, το Βασίλη, τον Αργύρη και τη Ντίνα …
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[PDF] Κλωνοποίηση, έκφραση του ενζύμου SIRT και μελέτη αλληλεπίδρασης του με βιοδραστικά εκχυλίσματα
ΤΡΟΦΙΜΩΝ, ΒΙΟΤΕΧΝΟΛΟΓΙΑΣ ΚΑΙ ΑΝΑΠΤΥΞΗΣ ΤΜΗΜΑ
ΒΙΟΤΕΧΝΟΛΟΓΙΑΣ ΕΡΓΑΣΤΗΡΙΟ ΕΝΖΥΜΙΚΗΣ ΤΕΧΝΟΛΟΓΙΑΣ ΠΜΣ …
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Summary Insulinomas are rare neuroendocrine tumours that classically present with fasting hypoglycaemia. This case report discusses an un...
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The online platform for Taylor & Francis Online content New for Canadian Journal of Remote Sen...
