Foxo1 is Required for Normal Somatotrope Differentiation

Endocrinology, Early Release.


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The Bone Sparing Effects of 2-methoxyestradiol are Mediated via Estrogen Receptor-α in Male Mice

Endocrinology, Early Release.


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Timed Inhibition of Orexin System by Suvorexant Improved Sleep and Glucose Metabolism in Type 2 Diabetic db/db Mice

Endocrinology, Early Release.


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Ghrelin octanoylation is completely stabilized in biological samples by alkyl fluorophosphonates

Endocrinology, Early Release.


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MATERNAL EXPOSURE TO BISPHENOL-A DURING PREGNANCY INCREASES PANCREATIC Β-CELL GROWTH DURING EARLY LIFE IN MALE MICE OFFSPRING

Endocrinology, Early Release.


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Stress increases gonadotropin inhibitory hormone cell activity and input to gonadotropin releasing hormone cells in ewes

Endocrinology, Early Release.


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TGFβ Superfamily Members Mediate Androgen Deprivation Therapy-Induced Obese Frailty in Male Mice

Endocrinology, Early Release.


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Female specific glucose-sensitivity of GnRH1 neurons leads to sexually dimorphic inhibition of reproduction in medaka

Endocrinology, Early Release.


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Animal models for glucocorticoid-induced postmenopausal osteoporosis: An updated review

Publication date: December 2016
Source:Biomedicine & Pharmacotherapy, Volume 84
Author(s): Zhida Zhang, Hui Ren, Gengyang Shen, Ting Qiu, De Liang, Zhidong Yang, Zhensong Yao, Jingjing Tang, Xiaobing Jiang, Qiushi Wei
Glucocorticoid-induced postmenopausal osteoporosis is a severe osteoporosis, with high risk of major osteoporotic fractures. This severe osteoporosis urges more extensive and deeper basic study, in which suitable animal models are indispensable. However, no relevant review is available introducing this model systematically. Based on the recent studies on GI-PMOP, this brief review introduces the GI-PMOP animal model in terms of its establishment, evaluation of bone mass and discuss its molecular mechanism. Rat, rabbit and sheep with their respective merits were chosen. Both direct and indirect evaluation of bone mass help to understand the bone metabolism under different intervention. The crucial signaling pathways, miRNAs, osteogenic- or adipogenic- related factors and estrogen level may be the predominant contributors to the development of glucocorticoid-induced postmenopausal osteoporosis.



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Comparable rest-related promotion of spatial memory consolidation in younger and older adults

Publication date: December 2016
Source:Neurobiology of Aging, Volume 48
Author(s): Michael Craig, Thomas Wolbers, Mathew A. Harris, Patrick Hauff, Sergio Della Sala, Michaela Dewar
Flexible spatial navigation depends on cognitive mapping, a function that declines with increasing age. In young adults, a brief period of postnavigation rest promotes the consolidation and integration of spatial memories into accurate cognitive maps. We examined (1) whether rest promotes spatial memory consolidation and integration in older adults; and (2) whether the magnitude of the rest benefit changes with increasing age. Young and older adults learned a route through a virtual environment, followed by a 10-minute delay comprising either wakeful rest or a perceptual task, and a subsequent cognitive mapping task, requiring the pointing to landmarks from different locations. Pointing accuracy was lower in the older than younger adults. However, there was a comparable rest-related enhancement in pointing accuracy in the 2 age groups. Together our findings suggest that (1) the age-related decline in cognitive mapping cannot be explained by increased consolidation interference in older adults; and (2) as we grow older, rest continues to support the consolidation and integration of spatial memories.



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Scholar : International Journal of Molecular Medicine - Volume:38 Number:4

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TABLE OF CONTENTS October 2016 Volume 38 Issue 4

The molecular basis of fertilization (Review) Katerina Georgadaki, Nikolas Khoury, Demetrios Spandidos, Vasilis Zoumpourlis View Abstract ❯

Regulatory effects of GRK2 on GPCRs and non-GPCRs and possible use as a drug target (Review) Chen-Chen Han, Yang Ma, Yifan Li, Yang Wang, Wei Wei View Abstract ❯

Oxidative stress in the trabecular meshwork (Review) Jing Zhao, Shuang Wang, Wei Zhong, Ben Yang, Lixia Sun, Yajuan Zheng View Abstract ❯

The molecular mechanisms of action of PPAR-γ agonists in the treatment of corneal alkali burns (Review) Hongyan Zhou, Wensong Zhang, Miaomiao Bi, Jie Wu View Abstract ❯

Occupational and environmental exposure to pesticides and cytokine pathways in chronic diseases (Review) Silvia Gangemi, Eliza Gofita, Chiara Costa, Michele Teodoro, Giusi Briguglio, Dragana Nikitovic, George Tzanakakis, Aristides Tsatsakis, Martin Wilks, Demetrios Spandidos, Concettina Fenga View Abstract ❯

Importance of the interaction between immune cells and tumor vasculature mediated by thalidomide in cancer treatment (Review) Xin Wang, Yanwei Shen, Shuting Li, Meng Lv, Xiaoman Zhang, Jiao Yang, Fan Wang, Jin Yang View Abstract ❯

Sphingosine 1-phosphate in metabolic syndrome (Review) Wei Chen, Hongwei Lu, Jie Yang, Hong Xiang, Hui Peng View Abstract ❯

Mitochondrial DNA depletion causes decreased ROS production and resistance to apoptosis Hulin Chen, Junling Wang, Zhongrong Liu, Huilan Yang, Yingjie Zhu, Minling Zhao, Yan Liu, Miaomiao Yan View Abstract ❯

5-Azacytidine suppresses EC9706 cell proliferation and metastasis by upregulating the expression of SOX17 and CDH1 Wenli Li, Dan Wu, Ziyu Niu, Dalei Jiang, Huan Ma, Heming He, Xiuli Zuo, Xiangjun Xie, Yuanlong He View Abstract ❯

Hepatocyte growth factor inhibits hypoxia/reoxygenation-induced activation of xanthine oxidase in endothelial cells through the JAK2 signaling pathway Ying Zhang, Shun Hu, Yun Chen, Ming Guo, Shan Wang View Abstract ❯

Functional differences between neonatal and adult fibroblasts and keratinocytes: Donor age affects epithelial-mesenchymal crosstalk in vitro Rosana Mateu, Veronika Živicová, Eliška Krejčí, Miloš Grim, Hynek Strnad, Čestmír Vlček, Michal Kolář, Lukáš Lacina, Peter Gál, Jiří Borský, Karel Smetana Jr, Barbora Dvořánková View Abstract ❯

Epigallocatechin-3-gallate prevents oxidative stress-induced cellular senescence in human mesenchymal stem cells via Nrf2 Joo-Hyun Shin, Hyo-Jin Jeon, Jihye Park, Mi-Sook Chang View Abstract ❯

Low vitamin D-modulated calcium-regulating proteins in psoriasis vulgaris plaques: S100A7 overexpression depends on joint involvement Susana Cubillos, Johannes Norgauer View Abstract ❯

Effects of recombinant human adenovirus-p53 on the regression of hepatic fibrosis Yehong Liu, Puye Yang, Na Chen, Shumei Lin, Min Liu View Abstract ❯

Anti-atherogenic effect of Humulus japonicus in apolipoprotein E-deficient mice Haian Lim, Jung-Ran Noh, Yong-Hoon Kim, Jung Hwang, Kyoung-Shim Kim, Dong-Hee Choi, Min-Jeong Go, Sang-Seop Han, Won-Keun Oh, Chul-Ho Lee View Abstract ❯

Targeted next-generation sequencing helps to decipher the genetic and phenotypic heterogeneity of hypertrophic cardiomyopathy Massimiliano Cecconi, Maria Parodi, Francesco Formisano, Paolo Spirito, Camillo Autore, Maria Musumeci, Stefano Favale, Cinzia Forleo, Claudio Rapezzi, Elena Biagini, Sabrina Davì, Elisabetta Canepa, Loredana Pennese, Mauro Castagnetta, Dario Degiorgio, Domenico Coviello View Abstract ❯

Interleukin-21 promotes osteoclastogenesis in RAW264.7 cells through the PI3K/AKT signaling pathway independently of RANKL Rui Xing, Yingjian Zhang, Changhong Li, Lin Sun, Lin Yang, Jinxia Zhao, Xiangyuan Liu View Abstract ❯

Metformin-suppressed differentiation of human visceral preadipocytes: Involvement of microRNAs Koji Fujita, Hisakazu Iwama, Kyoko Oura, Tomoko Tadokoro, Kayo Hirose, Miwako Watanabe, Teppei Sakamoto, Akiko Katsura, Shima Mimura, Takako Nomura, Joji Tani, Hisaaki Miyoshi, Asahiro Morishita, Hirohito Yoneyama, Keiichi Okano, Yasuyuki Suzuki, Takashi Himoto, Tsutomu Masaki View Abstract ❯

Three-dimensional co-culture of mesenchymal stromal cells and differentiated osteoblasts on human bio-derived bone scaffolds supports active multi-lineage hematopoiesis in vitro: Functional implication of the biomimetic HSC niche Xiaobing Huang, Biao Zhu, Xiaodong Wang, Rong Xiao, Chunsen Wang View Abstract ❯

Neuroprotective effects of sodium hydrosulfide against β-amyloid-induced neurotoxicity Xiao-Hui Li, Yuan-Yuan Deng, Fei Li, Jing-Shan Shi, Qi-Hai Gong View Abstract ❯

Glucagon-like peptide-1 attenuates advanced oxidation protein product-mediated damage in islet microvascular endothelial cells partly through the RAGE pathway Zhen Zhang, Lei Yang, Lei Lei, Rongping Chen, Hong Chen, Hua Zhang View Abstract ❯

Identification of hub genes and regulatory factors of glioblastoma multiforme subgroups by RNA-seq data analysis Yanan Li, Weijie Min, Mengmeng Li, Guosheng Han, Dongwei Dai, Lei Zhang, Xin Chen, Xinglai Wang, Yuhui Zhang, Zhijian Yue, Jianmin Liu View Abstract ❯

Notoginsenoside R1 ameliorates podocyte injury in rats with diabetic nephropathy by activating the PI3K/Akt signaling pathway Guodong Huang, Jianzhen Lv, Tongyu Li, Guoli Huai, Xiang Li, Shaowei Xiang, Longlong Wang, Zhenlin Qin, Jianli Pang, Bingyu Zou, Yi Wang View Abstract ❯

Pro-apoptotic effects of rHSG on C6 glioma cells Peng Gao, Yourui Zou, Bing Zhang, Shucai Jiang, Wenjiong Hao, Hui Guo, Guojin Huo, Juncheng Wang, Wei Zhao, Bing Shen View Abstract ❯

Bmi-1 promotes the invasion and migration of colon cancer stem cells through the downregulation of E-cadherin Zefeng Zhang, Xiaoling Bu, Hao Chen, Qiyi Wang, Weihong Sha View Abstract ❯

miR‑221 targets HMGA2 to inhibit bleomycin‑induced pulmonary fibrosis by regulating TGF‑β1/Smad3-induced EMT Yi‑Chun Wang, Jing‑Shi Liu, Hao‑Ke Tang, Jing Nie, Ji‑Xian Zhu, Ling‑Ling Wen, Qu‑Lian Guo View Abstract ❯

p43 induces IP-10 expression through the JAK-STAT signaling pathway in HMEC-1 cells Wei Wang, Junjie Tan, Yuhua Xing, Naipeng Kan, Jingyi Ling, Guifu Dong, Gang Liu, Huipeng Chen View Abstract ❯

Protective effects of miR-25 against hypoxia/reoxygenation‑induced fibrosis and apoptosis of H9c2 cells Qifang Liu, Yongjin Wang, Tianlun Yang, Wu Wei View Abstract ❯

Aspirin-triggered resolvin D1 inhibits TGF-β1-induced EMT through the inhibition of the mTOR pathway by reducing the expression of PKM2 and is closely linked to oxidative stress Yu Liu, Xiaolong Yuan, Wenhui Li, Qianqian Cao, Yusheng Shu View Abstract ❯

Identification of five novel arginine vasopressin gene mutations in patients with familial neurohypophyseal diabetes insipidus Dan Tian, Jing Cen, Min Nie, Feng Gu View Abstract ❯

Wogonin inhibits the proliferation and invasion, and induces the apoptosis of HepG2 and Bel7402 HCC cells through NF‑κB/Bcl-2, EGFR and EGFR downstream ERK/AKT signaling Xiaodong Liu, Shuo Tian, Mei Liu, Lingyan Jian, Limei Zhao View Abstract ❯

Cathepsin D is involved in the oxygen and glucose deprivation/reperfusion-induced apoptosis of astrocytes Jianlin Liu, Lin Yang, Hongyan Tian, Qiang Ma View Abstract ❯

Analgesic effects of 1,2,3,4,6-penta-O-galloyl-β-D-glucose in an animal model of lipopolysaccharide-induced pain Kun Chun, Si-Oh Kim, Sang-Han Lee View Abstract ❯

Naringenin pre-treatment inhibits neuroapoptosis and ameliorates cognitive impairment in rats exposed to isoflurane anesthesia by regulating the PI3/Akt/PTEN signalling pathway and suppressing NF-κB-mediated inflammation Fu-Zhou Hua, Jun Ying, Jing Zhang, Xi-Feng Wang, Yan-Hui Hu, Ying-Ping Liang, Qin Liu, Guo-Hai Xu View Abstract ❯

Anti-obesity effects of boiled tuna extract in mice with obesity induced by a high-fat diet Youngmin Kim, Mi-Jin Kwon, Jeong-Wook Choi, Min-Kyeong Lee, Chorong Kim, Jaehun Jung, Heny Aprianita, Heesop Nam, Taek-Jeong Nam View Abstract ❯

Identification of Mycobacterium tuberculosis in the cerebrospinal fluid of patients with meningitis using nested PCR Nora Rios-Sarabia, Olivia Hernández-González, Jorge González-Y-Merchand, Guadalupe Gordillo, Guillermo Vázquez-Rosales, Leopoldo Muñoz-Pérez, Javier Torres, Carmen Maldonado-Bernal View Abstract ❯

In vitro study comparing the efficacy of the water-soluble HSP90 inhibitors, 17-AEPGA and 17-DMAG, with that of the non‑water-soluble HSP90 inhibitor, 17-AAG, in breast cancer cell lines Tarik Ghadban, André Jessen, Matthias Reeh, Judith Dibbern, Sven Mahner, Volkmar Mueller, Ulrich Wellner, Cenap Güngör, Jakob Izbicki, Yogesh Vashist View Abstract ❯

Overexpression of miR-200a protects cardiomyocytes against hypoxia-induced apoptosis by modulating the kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 signaling axis Xiaoxia Sun, Hong Zuo, Chunmei Liu, Yafeng Yang View Abstract ❯

[Retracted] Systemic delivery of synthetic microRNA-451 is an effective therapeutic strategy for the treatment of lung cancer Baisong Lou, Xin Zhou View Abstract ❯

[Corrigendum] TLR4-mediated NF-κB signaling pathway mediates HMGB1-induced pancreatic injury in mice with severe acute pancreatitis Gang Li, Xuejun Wu, Le Yang, Yuxiang He, Yang Liu, Xing Jin, Hai Yuan View Abstract ❯

6-8 October, 2016, Metropolitan Hotel, Athens, Greece 21st World Congress on Advances in Oncology & 19th International Symposium on Molecular Medicine

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The effectiveness of habit reversal on treatment outcome and quality of life in patients with chronic eczema: a prospective observational study in the United Kingdom

Abstract

Our initial observation of the effectiveness of habit reversal for habitual scratching in the treatment of chronic eczema¹ led to its introduction at our UK clinic in 1989 ^2,3, and to the publication of our handbook for practitioners in 1996 ⁴. Between 2005 and 2006, a prospective observational study of 43 successive patients with chronic eczema was conducted to evaluate the effectiveness of habit reversal on disease severity and quality of life for up to 12 months. We recently read with interest the review by Daunton et al ⁵ on the use of habit reversal in eczema, in which 12 articles are considered - including 4 case reports, 3 case series and 3 RCTs. We note that the largest and most recent of these was in 1995, and included only 30 patients randomised to habit reversal.

This article is protected by copyright. All rights reserved.

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Homozygous SLCO2A1 Translation Initiation Codon Mutation in a Pakistani Family with Recessive Isolated Congenital Nail Clubbing (ICNC)

Abstract

Isolated congenital nail clubbing (ICNC; OMIM 119900) is a rare genodermatosis in which bilateral, symmetric enlargement of the nail plate and terminal segments of fingers and/or toes results from excessive proliferation of connective tissue between the nail matrix and distal phalanx. Loss of the normal angle between the nail and posterior nail fold is associated with a shiny, hypoplastic, thick-ended, long, broad nail. The thumbs are almost always involved, though some fingers or toes may be spared. Both autosomal dominant and autosomal recessive forms of ICNC have been described, sometimes associated with other systemic anomalies, which may include primary hypertrophic osteoarthropathy (PHO), the similar disorder pachydermoperiostitis (PDP), as well as cardiovascular, gastrointestinal, pulmonary and metabolic disorders.^1,2

^{This article is protected by copyright. All rights reserved.}

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Follicular Proliferation or Basal Cell Carcinoma? The first prospective UK study of this histological challenge during Mohs Surgery

Abstract

Mohs Micrographic Surgery (MMS) provides the highest cure rate for the treatment of BCC whilst maximising tissue conservation. Key to the success of MMS is the correct diagnosis of tumour. However, the facial area has a high density of follicular and sebaceous epithelia which can be difficult to distinguish from BCC. Folliculocentric basaloid proliferation (FBP) is a term which attempts to define these abnormal follicular entities, sometimes misdiagnosed as BCC. This was first described in a group of patients undergoing MMS for nasal and perinasal BCC, however the frequency is unreported.¹

This article is protected by copyright. All rights reserved.

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Psychiatric comorbidities in children and adolescents with psoriasis - a population-based cohort study

Abstract

Psoriasis is present in 2-3% of the adult European population¹ and 0.7-1.2% in children^1,2.

Adults with psoriasis have increased risk of depression³, and US data reported an increased risk of psychiatric diseases in pediatrics with psoriasis⁴, however European data are lacking.

Primary outcomes were to examine the risk of psychiatric disorders including use of psychopharmacotherapy in children with psoriasis compared to healthy controls in a population-based cohort study.

This article is protected by copyright. All rights reserved.

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Dermoscopic diagnosis of amelanotic/hypomelanotic melanoma

Abstract

Amelanotic/hypomelanotic melanoma (AHM) is a subtype including melanomas with little or no melanin pigmentation, amelanotic melanoma (AM); it represents 2-8 % of all melanomas.^1-2 AM may be difficult to diagnose because of lack of pigmentation and symmetry: recently, germline mutations have been reported in the MC1R gene and to a certain extent also in the MITF gene.³

^{This article is protected by copyright. All rights reserved.}

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Managing patients with delusional infestations in an integrated Psychodermatology clinic is much more cost effective than a general dermatology or primary care setting

Abstract

Delusional Infestation (DI) is a condition whereby patients hold a fixed, false belief of being infested with living organisms ¹. Patients classically present with excoriated skin at various stages of the healing process, together with evidence of their infestation (the specimen sign²) such as skin debris, insects or insect parts.. Patients also complain of a variety of cutaneous symptoms such as crawling, itching, burning and soreness. DI may occur as a primary disorder or as a consequence of medical illness³. A significant proportion of patients also have other associated dermato-psychological problems such as body dysmorphophobia, obsessive compulsive disorder and nodular prurigo. Sufferers often experience significant morbidity and reduction in quality of life.

This article is protected by copyright. All rights reserved.

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Functional expression of N-acetyltransferase 1 (NAT1) in differentiated human skin keratinocytes

Abstract

Allergic contact dermatitis to hair dye related molecules represents a considerable health concern. Para-phenylenediamine (PPD) is considered as key sensitizer in hair dye related allergic contact dermatitis. Mechanistically, oxidation of PPD was found to be of great importance for the induction of sensitization¹. Moreover, PPD can be N-acetylated by N-acetyltransferase 1 (NAT1) to mono- and diacetylated PPD in skin^2,3, while other conjugates were rarely detected⁴. N-acetylated PPD metabolites were classified as non-sensitizers in the murine local lymph node assay¹.

This article is protected by copyright. All rights reserved.

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Interviews with paediatric rheumatologists about psoriasis and psoriatic arthritis in children: How can specialties learn from each other?

Abstract

Opportunities exist for cross-specialty learning between dermatology and other medical disciplines; to the benefit of patients, clinical decision making and professional development. The Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) promotes the concept of 'psoriatic disease' to encompass psoriasis and psoriatic arthritis, and in their new disease management recommendations emphasise the importance of collaborative working between dermatologists and rheumatologists¹. Whilst the group primarily focuses on adult disease we suggest that a similar model should exist for the paediatric population.

This article is protected by copyright. All rights reserved.

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Familial white lentiginosis

Abstract

The term "white lentiginosis" (WL) was first reported in 1994 by Grosshans E et al (1), identifying a hypopigmented disorder of healthy individuals, clinically characterized by lenticular white macules and occurring most frequently in dark-colored individuals of phototype IV-V with a typical distribution on the trunk, décolleté, neck, hands and on the extensor surface of the upper arms. It is an acquired disorder with a chronic course and characterized by peculiar histhopathological features of lentiginosis hyperplasia with hypopigmentation.

This article is protected by copyright. All rights reserved.

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Multifaceted role of hair follicle dermal cells in bioengineered skins

Abstract

Background

The method to generate bioengineered skin constructs was pioneered several decades ago, and nowadays these constructs are used regularly for the treatment of severe burns and non-healing wounds. Commonly, these constructs are comprised of skin fibroblasts within a collagen scaffold, forming the skin dermis, and stratified keratinocytes overlying this, forming the skin epidermis. In the past decade there has been a surge of interest in bioengineered skins, with researchers searching for alternative cell sources, or scaffolds, from which constructs can be established, and for more biomimetic equivalents with skin appendages.

Objectives

In this manuscript we wanted to evaluate whether human hair follicle dermal cells can act as an alternative cell source for engineering the dermal component of engineered skin constructs.

Methods

We established in vitro skin constructs by incorporating into the collagenous dermal compartment either primary interfollicular dermal fibroblasts, hair follicle dermal papilla, or hair follicle dermal sheath cells. In vivo skins were established by mixing dermal cells and keratinocytes in chambers on top of immunologically compromised mice.

Results

All fibroblast subtypes were capable of supporting growth of overlying epithelial cells, both in vitro and in vivo. However, we found hair follicle dermal sheath cells to be superior to fibroblasts in their capacity to influence the establishment of a basal lamina.

Conclusions

Human hair follicle dermal cells can be readily interchanged with interfollicular fibroblasts, and used as an alternative cell source for establishing the dermal component of engineered skin both in vitro and in vivo.

This article is protected by copyright. All rights reserved.

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Psychiatric Emergencies for Clinicians: Emergency Department Management of Benzodiazepine Withdrawal

Publication date: Available online 28 September 2016
Source:The Journal of Emergency Medicine
Author(s): Sara E. Puening, Michael P. Wilson, Kimberly Nordstrom




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Emergent Needle Aspiration of an Orbital Subperiosteal Hematoma

Publication date: Available online 28 September 2016
Source:The Journal of Emergency Medicine
Author(s): Abdul Shameer, Neelam Pushker, Gautam Lokdarshi, Shabeer Basheerz, Mandeep S. Bajaj
BackgroundDelayed presentation of orbital trauma as an acute subperiosteal hematoma.Case reportA 12-year-boy developed sudden painful abaxial proptosis of the left eyeball 15 days after blunt trauma over the forehead. On contrast-enhanced computed tomography, a heterogeneous, hypodense, non-enhancing mass with biconvex contour was seen adjacent to the orbital roof. Direct needle drainage was performed and about 10 mL dark blood was aspirated. Proptosis reduced immediately and resolved completely at 2 weeks follow-up.Why Should an Emergency Physician Be Aware of This?Sudden proptosis with no immediate history of trauma can be alarming for the emergency physician. Familiarity with this clinical entity and early drainage can decrease morbidity.



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Does the National Resident Match Program Rank List Predict Success in Emergency Medicine Residency Programs?

Publication date: Available online 28 September 2016
Source:The Journal of Emergency Medicine
Author(s): Michael Van Meter, Michael Williams, Rosa Banuelos, Peter Carlson, Jeffrey I. Schneider, Bradley D. Shy, Christine Babcock, Matthew Spencer, Yashwant Chathampally
BackgroundEmergency medicine (EM) residency programs use nonstandardized criteria to create applicant rank lists. One implicit assumption is that predictive associations exist between an applicant's rank and their future performance as a resident. To date, these associations have not been sufficiently demonstrated.ObjectivesWe hypothesized that a strong positive correlation exists between the National Resident Match Program (NRMP) match-list applicant rank, the United States Medical Licensing Examination (USMLE) Step 1 and In-Training Examination (ITE) scores, and the graduating resident rank.MethodsA total of 286 residents from five EM programs over a 5-year period were studied. The applicant rank (AR) was derived from the applicant's relative rank list position on each programs' submitted NRMP rank list. The graduation rank (GR) was determined by a faculty consensus committee. GR was then correlated to AR using a Spearman's partial rank correlation. Additional correlations were sought with a ranking of the USMLE Step Score (UR) and the ITE Score (IR).ResultsCombining data for all five programs, weak positive correlations existed between GR and AR, UR, and IR. The majority of correlations ranged between. When comparing GR and AR, there was a weak correlation of 0.13 (p = 0.03).ConclusionOur study found only weak correlations between GR and AR, UR, and IR, suggesting that those variables may not be strong predictors of resident performance. This has important implications for EM programs considering the resources devoted to applicant evaluation and ranking.



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Delayed Antitoxin Treatment of Two Adult Patients with Botulism after Cosmetic Injection of Botulinum Type A Toxin

Publication date: Available online 28 September 2016
Source:The Journal of Emergency Medicine
Author(s): Kit-Ling Fan, Yan-Li Wang, Gary Chu, Ling-Pong Leung
BackgroundInjection of botulinum toxin type A for cosmetic purposes is common. It is believed to be safe, but adverse reactions have been reported, including dysphagia, generalized paralysis, respiratory depression, and death caused by focal injection of the toxin. Early administration of antitoxin in patients with adverse reactions is the mainstay of management, but the time window for its clinical efficacy is not well defined.Case ReportsTwo female adult patients with clinical botulism after botulinum toxin type A injection are described. Both patients had received intramuscular injection of botulinum toxin type A in their calves at beauty shops for cosmetic reasons. They developed clinical botulism about 3 days postinjection. They presented late to the emergency department. Monovalent type A botulinum antitoxin was administered 7 and 9 days from symptom onset, respectively. Both patients showed clinical improvement after the antitoxin treatment.Why Should an Emergency Physician Be Aware of This?Patients may present to the emergency department with systemic effects of botulinum toxin type A after cosmetic injection. Clinical efficacy of botulinum antitoxin treatment was observed in two patients who were given the drug 7 and 9 days after the occurrence of symptoms of botulism after cosmetic injection of botulinum toxin type A. It may be worthwhile to commence antitoxin treatment even if patients present late.



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Influenza in the Emergency Department: Vaccination, Diagnosis, and Treatment

Publication date: Available online 27 September 2016
Source:The Journal of Emergency Medicine
Author(s): Christopher J. Coyne, Michael K. Abraham, Jack Perkins, Gary M. Vilke




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Ameloblastoma versus basal cell carcinoma: an immunohistochemical comparison

Publication date: Available online 28 September 2016
Source:Annals of Diagnostic Pathology
Author(s): Salam N. Jawad, Bashar H. Abdullah
Despite behavioral mimicry of ameloblastoma (AB) and basal cell carcinoma (BCC); they are classified at two extremes within pertinent WHO classifications with respect to benign and malignant designation. This study aims to appraise the current allocation of ameloblastoma in the classification through an immunohistochemical comparison of some aspects of behavior with basal cell carcinoma. Sections from retrospectively retrieved formalin fixed - paraffin embedded tissue blocks of ameloblastoma (n=37) and basal cell carcinoma (n=34) were comparatively examined for the immunohistochemical expression for Ki-67, Bcl-2, MMP-2, MMP-9, CD31 and D2–40 monoclonal antibodies. No statistically significant differences between the tumors were found regarding the immunoexpressions of Bcl-2 (P=.252), CD31 microvessel density (MVD) (P=.895), lymphatic vessel density (LVD) (P=.642) and MMP-9 stromal expression (P=.083). MMP-2 expression was significantly higher in epithelial and stromal regions of AB (P=.009, P=.001; respectively) whereas Ki-67 and MMP-9 epithelial expression were significantly higher in BCC (P<.000, P=.026; respectively). Within the studied immunohistochemical attributes for tumor behavior, the study accentuated the overall behavioral mimicry of the tumors and indicated that basal cell carcinomas surmount ameloblastomas by the proliferative rate only.



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Identification of genetic variation in the lncRNA HOTAIR associated with HPV16-related cervical cancer pathogenesis

Abstract

Purpose

Previously, over-expression of the long noncoding RNA (lncRNA) HOTAIR has been found to be associated with the invasive and metastatic capacities of several epithelial cancers, including cervical cancer (CaCx). Here, we aimed at identifying functionally relevant genetic variants that may be employed to differentiate between clinically distinct CaCx subtypes, i.e., those exhibiting high HOTAIR levels and molecular signatures of metastasis and those lacking such signatures in the presence of low HOTAIR expression levels.

Methods

Genomic DNA isolated from various cervical tissue samples (characterized by histopathology and HPV status) was used for HOTAIR amplicon sequencing, followed by validation of the findings by Sanger sequencing. The impact of the genetic variants found on the secondary structure of HOTAIR and the concomitant alterations in miRNA binding sites were determined through in silico analysis, followed by miRNA expression analysis by quantitative real-time PCR and confirmation of miRNA binding using a luciferase reporter assay.

Results

We found that rs2366152C was over-represented [OR_age-adjusted = 2.58 (1.23–5.57); p = 0.014] in low HOTAIR expressing HPV positive CaCx cases compared to HPV negative controls. This genetic variant showed the propensity of a secondary structure alteration and gain of a miR-22 binding site in HOTAIR, which was found to be concordant with miR-22 over-expression in low HOTAIR CaCx cases compared to controls. We found that miR-22 expression negatively correlated with HOTAIR and E7 expression in HPV16 positive cases and in an E7 transfected HPV negative CaCx-derived cell line (C33A), but was not altered in high HOTAIR cases compared to controls. Reduced luciferase activity of a HOTAIR rs2366152C expression plasmid in C33A cells through miR-22 co-transfection confirmed the ability of miR-22 to specifically target rs2366152C-harbouring HOTAIR lncRNA in CaCx cells, ultimately leading to its down-regulation.

Conclusions

Our data indicate that rs2366152C not only has the potential to serve as a marker for singling out CaCx cases lacking metastatic molecular signatures, but also to explain the functional inactivation of HOTAIR in these cases, including the mechanism of its down-regulation.

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Epigenetic Regulation of the Thermogenic Adipose Program

Publication date: Available online 28 September 2016
Source:Trends in Endocrinology & Metabolism
Author(s): Audrey Sambeat, Olga Gulyaeva, Jon Dempersmier, Hei Sook Sul
In contrast to white adipose tissue (WAT), which stores energy in the form of triglycerides, brown adipose tissue (BAT) dissipates energy by producing heat to maintain body temperature by burning glucose and fatty acids in a process called adaptive thermogenesis. The presence of an inducible thermogenic adipose tissue, and its beneficial effects for maintaining body weight and glucose and lipid homeostasis, has raised intense interest in understanding the regulation of thermogenesis. Elucidating the regulatory mechanisms underlying the thermogenic adipose program may provide excellent targets for therapeutics against obesity and diabetes. Here we review recent research on the role of epigenetics in the thermogenic gene program, focusing on DNA methylation and histone modifications.



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Linear Trichilemmomas on the Ankle of a 28 year-old Female

Abstract

Trichilemmomas are benign cutaneous proliferations derived from the outer root sheath of the hair follicle. They most often occur on the head and neck region and show a female predominance. When multiple, they are associated with Cowden syndrome (CS), a rare disorder due to an autosomal dominant germline mutation in PTEN (phosphatase and tensin homolog on chromosome 10), a tumor suppressor gene. Trichilemmomas outside of the head and neck region are rare, and as such, the association with CS is not clear. A 28 year old healthy female with no significant family history of cancer presented to her dermatologist with multiple erythematous papules on the left anterior ankle, starting at birth. A shave biopsy confirmed the diagnosis of trichilemmoma with focal desmoplastic features (or desmoplastic trichilemmoma). A PTEN immunohistochemical study showed patchy (but not complete) loss of staining of the lesional cells. After shave removal, the trichilemmomas recurred 1–2 months later

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Black Veins: A Case of Minocycline-induced Pigmentation Post-Sclerotherapy and a Review of Literature

Abstract

Minocycline-induced pigmentation (MIP) is an uncommon but well described adverse effect of oral minocycline treatment. MIP is clinically and histopathologically distinct from post-sclerotherapy pigmentation. We report a case of a patient presenting with blackened skin overlying veins recently treated with endovenous laser and foam sclerotherapy. The patient was a 44 year-old male with systemic sclerosis who commenced minocycline for the treatment of rosacea 5 months prior. Histological examination of the discoloured tissue and underlying vein revealed hemosiderin deposition in the dermis and pigmented macrophages within the subendothelial layer of the vein wall with a staining pattern consistent with MIP. Venous tissue has not previously been reported in the literature as a target of minocycline pigmentation. Our patient preferred to control his rosacea by continuing to take minocycline. Follow-up ultrasound examinations revealed the treated vessels to be fully occluded with no evidence of recanalization, residual flow or ongoing thrombophlebitis. Despite a good sclerotherapy outcome, the pigmentation did not subside over 2 years. This case demonstrates that oral minocycline may induce significant and potentially long-term pigmentation in predisposed patients undergoing sclerotherapy.

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Primary scalp alopecia: New histopathological tools, new concepts and a practical guide to diagnosis

Abstract

The diagnosis of primary scalp alopecia remains one of the most challenging fields in dermatopathology. In this review, we would like to connect the established classification of primary alopecia into scarring (cicatricial) and non-scarring (non-cicatricial) with current concepts. We introduce a simplified pathway for the diagnosis of the most common causes of alopecia, including a discussion of tissue processing techniques and use of immunohistochemistry.

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Multiple Clear Cell Acanthomas and a Sebaceous Lymphadenoma Presenting In a Patient with Cowden Syndrome – A Case Report

Abstract

Cowden Syndrome (CS) is an uncommon autosomal dominant multiorgan/system genodermatosis. It is characterized by the development of multiple hamartomas of endodermal, mesodermal and ectodermal origin, an increased lifetime risk of breast, thyroid, endometrial, and other cancers and an identifiable germline mutation. Mucocutaneous hamartomas are the most common lesions seen and mainly include facial trichilemmomas, oral mucosal papillomas, and benign acral keratoses. Herein, we report a case of a 63-year-old Caucasian male with a long-established diagnosis of CS and history of thyroid cancer, colonic polyps, and innumerable trichilemmomas, seborrheic keratoses, squamous papillomas, and non-melanoma skin cancers excised in the past. He presented in four separate occasions with small skin-colored papulonodular lesions that upon excision revealed to be clear cell acanthomas. He also developed a tumor in the preauricular area that was completely resected and was found to be a sebaceous lymphadenoma of the parotid gland. This is to our knowledge, the second report of clear cell acanthoma and also the second reported case of sebaceous lymphadenoma in a patient with CS.

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Enhancement and Passive Acoustic Mapping of Cavitation from Fluorescently Tagged Magnetic Resonance-Visible Magnetic Microbubbles In Vivo

Publication date: Available online 22 September 2016
Source:Ultrasound in Medicine & Biology
Author(s): Calum Crake, Joshua Owen, Sean Smart, Christian Coviello, Constantin-C. Coussios, Robert Carlisle, Eleanor Stride
Previous work has indicated the potential of magnetically functionalized microbubbles to localize and enhance cavitation activity under focused ultrasound exposure in vitro. The aim of this study was to investigate magnetic targeting of microbubbles for promotion of cavitation in vivo. Fluorescently labelled magnetic microbubbles were administered intravenously in a murine xenograft model. Cavitation was induced using a 0.5-MHz focused ultrasound transducer at peak negative focal pressures of 1.2–2.0 MPa and monitored in real-time using B-mode imaging and passive acoustic mapping. Magnetic targeting was found to increase the amplitude of the cavitation signal by approximately 50% compared with untargeted bubbles. Post-exposure magnetic resonance imaging indicated deposition of magnetic nanoparticles in tumours. Magnetic targeting was similarly associated with increased fluorescence intensity in the tumours after the experiments. These results suggest that magnetic targeting could potentially be used to improve delivery of cavitation-mediated therapy and that passive acoustic mapping could be used for real-time monitoring of this process.



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Scholar : These new articles for Amyloid are available online

The online platform for Taylor & Francis Online content New for Amyloid and online now on Taylor & Francis Online: Original Article Immunoglobulin heavy light chain test quantifies clonal disease in patients with AL amyloidosis and normal serum free light chain ratio Tatiana Prokaeva, Brian Spencer, Fangui Sun, Richard M. O'Hara, David C. Seldin, Lawreen H. Connors & Vaishali Sanchorawala Pages: 1-7 | DOI: 10.1080/13506129.2016.1219715 eHealth and mHealth Free Access Article Collection – click here This message is personalised to your status as a society member. Please do not forward this email. To recommend content, please use the social sharing tools on the website. To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : These new articles for Acta Odontologica Scandinavica are available online

The online platform for Taylor & Francis Online content New for Acta Odontologica Scandinavica and online now on Taylor & Francis Online: Review Article Use of platelet concentrates in oral and maxillofacial surgery: an overview Zornitsa Mihaylova, Vanyo Mitev, Pavel Stanimirov, Antonia Isaeva, Natalia Gateva & Nikolay Ishkitiev Pages: 1-11 | DOI: 10.1080/00016357.2016.1236985 Peripheral calcifying cystic odontogenic tumour and peripheral dentinogenic ghost cell tumour: an updated systematic review of 117 cases reported in the literature Bruno Ramos Chrcanovic & Ricardo Santiago Gomez Pages: 1-7 | DOI: 10.1080/00016357.2016.1236986 Original Article A comparison of the use of cone-beam computed tomography and panoramic radiography in the assessment of pre-eruptive intracoronal resorption Omer Demirtas, Asım Dane & Eren Yildirim Pages: 1-6 | DOI: 10.1080/00016357.2016.1235227 Peruse papers around Sustainable Development Goal 6: 'Ensure availability and sustainable management of water and sanitation for all' with free online access. This message is personalised to your status as a society member. Please do not forward this email. To recommend content, please use the social sharing tools on the website. To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : These new articles for Asia Pacific Translation and Intercultural Studies are available online

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The online platform for Taylor & Francis Online content New for Asia Pacific Translation and Intercultural Studies and online now on Taylor & Francis Online: Original Articles On the translation, promotion and acceptance of Chinese philosophy in English-speaking world: an interview with Prof. Philip J. Ivanhoe Jianlan Lyu, Xiaoli Tan & Yong Lang Pages: 1-4 | DOI: 10.1080/23306343.2016.1230298 Audienceship and community of practice: an exploratory study of Chinese fansubbing communities Szu-Wen Kung Pages: 1-15 | DOI: 10.1080/23306343.2016.1225329 The Master said, the Master exclaimed: reporting verbs and the image of Huineng in translations of the Platform Sutra Hailing Yu & Shangxing Guo Pages: 1-13 | DOI: 10.1080/23306343.2016.1228148 Time and tide wait for no man (or woman). Explore the multidisciplinary TIME Collection now. This message is personalised to your status as a society member. Please do not forward this email. To recommend content, please use the social sharing tools on the website. To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

The Skin Aging Exposome

Publication date: Available online 28 September 2016
Source:Journal of Dermatological Science
Author(s): Jean Krutmann, Anne Bouloc, Gabrielle Sore, Bruno A. Bernard, Thierry Passeron
The term "exposome" describes the totality of exposures to which an individual is subjected from conception to death. It includes both external and internal factors as well as the human body's response to these factors. Current exposome research aims to understand the effects all factors have on specific organs, yet today, the exposome of human skin has not received major attention and a corresponding definition is lacking. This review was compiled with the collaboration of European scientists, specialized in either environmental medicine or skin biology. A comprehensive review of the existing literature was performed using PubMed. The search was restricted to exposome factors and skin aging. Key review papers and all relevant, epidemiological, in vitro, ex vivo and clinical studies were analyzed to determine the key elements of the exposome influencing skin aging. Here we propose a definition of the skin aging exposome. It is based on a summary of the existing scientific evidence for the role of exposome factors in skin aging. We also identify future research needs which concern knowledge about the interaction of distinct exposomal factors with each other and the resulting net effects on skin aging and suggest some protective measures.



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microRNA-21 mediates the TGF-β1-induced migration of keratinocytes via targeting PTEN

OBJECTIVE: The aim of this study was to investigate the molecular mechanism into the keratinocyte migration, which is promoted by Transforming growth factor-β1 (TGF-β1) during wound healing.

MATERIALS AND METHODS: In the present study, we investigated the regulation by TGF-β1 on phosphatase and tensin homolog (PTEN) expression, and microRNA-21 (miR-21) level with real-time quantitative PCR or/and Western blotting, and then examined the regulatory role of miR-21 on the PTEN expression and the mesenchymal transition, with real-time quantitative PCR, western blotting and luciferase reporter assay, and the migration of keratinocytic HaCaT cells with scratch assay.

RESULTS: It was demonstrated that miR-21 was upregulated by TGF-β1 treatment in HaCaT cells; and the upregulated miR-21 targeted the 3′ UTR of PTEN gene and downregulated the PTEN expression, along with the Smad3/4 upregulation. Moreover, the miR-21 manipulation with miR-21 mimics or miR-21 inhibitor not only upregulated or downregulated the miR-21 level, but also associated with the mesenchymal transition and the migration of HaCaT cells via promoting or downregulating the FSP1 and Collagen I and the E-cadherin, and via upregulating or downregulating the migration of HaCaT cells.

CONCLUSIONS: Our results demonstrate that miR-21 mediates the TGF-β1-promoted mesenchymal transition and migration of keratinocytes during skin wound healing via targeting PTEN. This study implies that miR-21 might be an important target to promote the skin wound healing.

L'articolo microRNA-21 mediates the TGF-β1-induced migration of keratinocytes via targeting PTEN sembra essere il primo su European Review.

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The evaluation of prepared microgroove pattern by femtosecond laser on alumina-zirconia nano-composite for endosseous dental implant application

Abstract

Ceramic dental materials, especially alumina (20 %vol)-yttrium stabilized tetragonal zirconia poly crystal (A-Y-TZP20), have been considered as alternatives to metals for endosseous dental implant application. For increasing the bone-to-implant contact as well as the speed of bone formation, a new surface modification can be effective. The aim of this study was to design microgroove patterns by femtosecond laser on A-Y-TZP20 nano-composite disks for endosseous dental implant application. The phase composition and the morphology of the A-Y-TZP20 nano-composite samples were characterized using X-ray diffraction and Scanning electron microscopy equipped with energy dispersive X-ray spectroscopy techniques. Statistical analysis was submitted to Kolmogorov-Smirnov test and Student's t test for independent variables, with a 5 % significance level. EDAX analysis revealed a significant decrease in the relative content of contaminants like carbon (p < 0.05) in laser surface-treated group as compared to non surface-treated group. X-ray diffraction did not show any change in the crystalline structure induced by laser processing. It was concluded that the femtosecond laser is a clean and safe method for surface modification of A-Y-TZP20.

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Effects of diode laser (980 nm) on orthodontic tooth movement and interleukin 6 levels in gingival crevicular fluid in female subjects

Abstract

The aim of this study was to evaluate the effects of low-level laser irradiation on the rate of orthodontic tooth movement (OTM) and the interleukin-6 (IL-6) concentration in gingival crevicular fluid (GCF) during orthodontic treatment. In this randomized split-mouth double blind clinical trial, 11 female patients aged 14 to 25 years (mean 19 ± 4.21 year), who required canine retraction following four first premolars extraction, were selected. The GaAlAs laser diode laser (A.R.C. Laser GmbH, Nürnberg, Germany) (980 nm, 100 mW, 5.6 J/cm², three points from the buccal side and three from lingual side of the tooth, 56 s, running in continuous mode) was used for canine retraction in only one maxillary quadrant (LG). The irradiation time for each cervical and middle third of the tooth was 10 s, and 8 s for the apical third of the tooth. The other maxillary quadrant served as the control group (CG) using the laser pseudo-application in this side. The laser irradiation was applied on days 0, 7, 14, 21, and 28 of each month during the canine retraction phase. Canine retraction was done using closed coil spring with 150 g force on rectangular wires after the alignment and leveling. This study was done in 11 months. Dental casts were made at different time points during the treatment, and the amount of tooth movement was measured. To evaluate the levels of IL-6, GCF samples were collected from the distal side of the maxillary canine teeth on both quadrants at the beginning of the trial, the end of aligning phase, and on day 21 of each month during canine retraction. Although the mean rate of canine retraction was higher in the LG (0.013) than the CG (0.012) and there was definitely a tendency for more canine retraction in the LLLI, but the results failed to show any significant difference between the mean rate of canine retraction of both groups (P = 0.068). A paired t test showed that there was no significant difference in the mean concentration of IL-6 at various stages of the treatment between the groups during canine distalization (P > 0.05). Therefore, conclusive evidence could not be provided to support the efficacy of the diode laser (980 nm) in accelerating OTM in female subject.

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Erratum to: Ablation of carious dental tissue using an ultrashort pulsed laser (USPL) system

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Scholar : These new articles for Applied Neuropsychology: Child are available online

The online platform for Taylor & Francis Online content New for Applied Neuropsychology: Child and online now on Taylor & Francis Online: Original Articles Neuropsychological assessment of executive functions following pediatric traumatic brain injury K. Drorit Gaines & Henry V. Soper Pages: 1-13 | DOI: 10.1080/21622965.2016.1229406 Routledge Psychoanalysis Like the Facebook Page for the latest Psychoanalysis news and offers. This message is personalised to your status as a society member. Please do not forward this email. To recommend content, please use the social sharing tools on the website. To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Serum 25-hydroxyvitamin D Concentration is not associated with Glomerular Filtration Rate in a Predominantly Obese otherwise Healthy Population

Publication date: Available online 28 September 2016
Source:The Journal of Steroid Biochemistry and Molecular Biology
Author(s): Negar Naderpoor, Aya Mousa, Maximilian P.J. de Courten, Robert Scragg, Sanjeeva Ranasinha, Barbora de Courten
Evidence from observational studies indicates a role for vitamin D in kidney function and progression to chronic kidney disease. Findings from animal studies have proposed underlying mechanisms including increased activation of the renin-angiotensin system, increased blood pressure, insulin resistance and chronic low-grade inflammation. However, human studies are limited by confounders arising from heterogeneous samples of participants. We examined the relationship between 25(OH)D and estimated glomerular filtration rate (eGFR) in a predominantly obese otherwise healthy and drug-naive population with no history of chronic kidney disease (CKD).One hundred and twenty one non-diabetic (75g oral glucose tolerance test; OGTT) volunteers (70 males and 51 females), aged 18–57 years participated in the study. Median 25(OH)D level was 37nmol/L with no difference by sex. Twenty six participants (21.5%) had 25(OH)D <25 nmol/L, 75 participants (62%) had 25(OH)D of 25–49.99nmol/L, and 20 participants (16.5%) had 25(OH)D ≥50nmol/L. In univariate analysis, 25(OH)D was related negatively to percent body fat and 2-hour glucose level post OGTT. Mean (SD) eGFR was 113.1 (14.9) mL/min/1.73m², and in the multivariable analysis, it was related to age, sex, percent body fat and 2-hour glucose level post OGTT, but not to 25(OH)D. Furthermore, there was no relationship between eGFR and 25(OH)D across BMI categories.Our data suggest that measuring 25(OH)D in predominantly obese otherwise healthy individuals with no history of CKD may not be beneficial in early recognition of kidney disease.



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Scholar : These new articles for Asian Geographer are available online

The online platform for Taylor & Francis Online content New for Asian Geographer and online now on Taylor & Francis Online: Original Articles The political economy of 2015 Nepal earthquake: some critical reflections Kapil Dev Regmi Pages: 1-20 | DOI: 10.1080/10225706.2016.1235053 Political Communication Free Access Virtual Special Issue: US Elections & Campaigns This message is personalised to your status as a society member. Please do not forward this email. To recommend content, please use the social sharing tools on the website. To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.