Anisotropic tough double network hydrogel from fish collagen and its spontaneous in vivo bonding to bone

Publication date: July 2017
Source:Biomaterials, Volume 132
Author(s): Md. Tariful Islam Mredha, Nobuto Kitamura, Takayuki Nonoyama, Susumu Wada, Keiko Goto, Xi Zhang, Tasuku Nakajima, Takayuki Kurokawa, Yasuaki Takagi, Kazunori Yasuda, Jian Ping Gong
Soft supporting tissues in the human body, such as cartilages and ligaments, are tough materials and firmly fixed to bones. These soft tissues, once injured, cannot regenerate spontaneously invivo. Developing tough and biocompatible hydrogels as artificial soft supporting tissues would substantially improve outcomes after soft tissue injury. Collagen is the main rigid component in soft connective tissues which is organized in various hierarchical arrays. We have successfully developed a novel class of collagen fibril-based tough hydrogels based on the double network (DN) concept using swim bladder collagen (SBC) extracted from Bester sturgeon fish. The DN hydrogels, SBC/PDMAAm, are composed of physically/chemically crosslinked anisotropic SBC fibril as the first network and neutral, biocompatible poly(N,N′-dimethylacrylamide) (PDMAAm) as the second network. The anisotropic structure of SBC fibril network, which is well retained in the DN hydrogels, is formed by free injection method, taking advantage of the excellent fibrillogenesis capacity of SBC. The denaturation temperature of collagen is improved in the DN hydrogels. These DN gels possess anisotropic swelling behavior, exhibit excellent mechanical properties comparable to natural cartilage. The 4 weeks implantation of the gels in the osteochondral defect of rabbit knee also shows excellent biomechanical performance in vivo. Furthermore, the hydroxyapatite (HAp) coated DN gels, HAp/SBC/PDMAAm gels, strongly bond to bone after 4 weeks. This new class of collagen-based hybrid DN gels, as soft and elastic ceramics, having good biomechanical performance and strong bonding ability with bone would expand the choice for designing next-generation orthopedic implants such as artificial cartilage, bone defect repair material in the load-bearing region of the body.

Graphical abstract

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Activatable near infrared dye conjugated hyaluronic acid based nanoparticles as a targeted theranostic agent for enhanced fluorescence/CT/photoacoustic imaging guided photothermal therapy

Publication date: July 2017
Source:Biomaterials, Volume 132
Author(s): Xiaolong Liang, Lei Fang, Xiaoda Li, Xu Zhang, Fan Wang
Targeted theranostic nano-system integrating functions of both diagnosis and therapy shows great potential for improving diagnosis and therapeutic efficacy. Herein, multifunctional nanoparticle based on activatable hyaluronic acid (HA) conjugating two near-infrared (NIR) dyes of Cy5.5 and IR825 was successfully designed and fabricated, and simultaneously used as a carrier for encapsulating perfluorooctylbromide (PFOB). In this system, PFOB showed good capability to absorb the X-rays, Cy5.5 on the outer surface acted as a fluorescent dye activatable by hyaluronidases (Hyals) in the tumor, and IR825 in the core as a photothermal agent. The obtained nanoparticles (NPs) of PFOB@IR825-HA-Cy5.5 can be utilized for triple X-ray computed tomography (CT), fluorescence and photoacoustic imaging. When PFOB@IR825-HA-Cy5.5 NPs were intravenously injected into the mice bearing HT-29 tumor, efficient tumor accumulation was clearly observed, as revealed by the triple modal imaging. An in vivo tumor treatment experiment was conducted by combination of PFOB@IR825-HA-Cy5.5 and near-infrared laser irradiation, achieving effective tumor ablation in mice. Therefore, PFOB@IR825-HA-Cy5.5 NPs is a safe, efficient, imageable photothermal nanoprobe, showing great potential for cancer theranostics.

Graphical abstract

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Peptide valency plays an important role in the activity of a synthetic fibrin-crosslinking polymer

Publication date: July 2017
Source:Biomaterials, Volume 132
Author(s): Robert J. Lamm, Esther B. Lim, Katie M. Weigandt, Lilo D. Pozzo, Nathan J. White, Suzie H. Pun
Therapeutic polymers have the potential to improve the standard of care for hemorrhage, or uncontrolled bleeding, as synthetic hemostats. PolySTAT, a fibrin-crosslinking peptide-polymer conjugate, has the capacity to rescue fibrin clot formation and improve survival in a model of acute traumatic bleeding. PolySTAT consists of a synthetic polymer backbone to which targeting fibrin-binding peptides are linked. For translation of PolySTAT, the optimal valency of peptides must be determined. Grafting of fibrin-binding peptides to the poly(hydroxyethyl methacrylate)-based backbone was controlled to produce peptide valencies ranging from 0 to 10 peptides per polymer. PolySTATs with valencies of ≈4 or greater resulted in increased clot firmness, kinetics, and decreased breakdown as measured by thromboelastometry. A valency of ≈4 increased clot firmness 57% and decreased clot breakdown 69% compared to phosphate-buffered saline. This trend was characterized by neutron scattering, which probed the structure of clots formed in the presence of PolySTAT. Finally, PolySTAT with valencies of 4 (100% survival; p = 0.013) and 8 (80% survival; p = 0.063) improved survival compared to an albumin control in a femoral artery injury model (20% survival). This work demonstrates tunability of hemostatic polymers and the ability of in vitro assays to predict in vivo efficacy.

Graphical abstract

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Determination of forces on a split palatal screw after rapid maxillary expansion

Abstract

Objectives

Aim of this study was to develop a finite element model of the forces that patients with rapid maxillary expansion bear and to validate it by a mechanical test.

Methods

Computer-aided design models of the metallic screw and polymeric splint were modelled and discretized. Two forces were generated and considered independently: F1 at the temporary molar (2.5 N) and F2 at the permanent molar (2.5 N). The results of the finite element analysis were used to define the strain values which the anterior and posterior arms of the rapid maxillary expansion appliance bore as a linear function of F1–F2 by calculating the strain–force coefficient δ _ij . Two strain gauge rosettes were attached to an appliance which was placed in an XY motorized stage to reproduce the same forces used in the finite element analysis. Once the system was validated, the matrix was inverted to determine forces F1 and F2 that a group of 40 patients underwent (median age 8.33 years, standard deviation 1.86 years) for 75 days, using their strain values. The parents of the patients activated a quarter turn (0.20 mm) twice a day until 50% transversal overcorrection was achieved.

Results

Finite element analysis showed that the effects of the forces on stress at the location of the arms were notably different. There was a satisfactory correlation between finite element analysis predictions and in vitro values. Dissipation of F1 and F2 in patients was predicted to be 62.5 and 80%, respectively, after 75 days of retention.

Conclusion

These results back the finite element analysis model for force prediction.

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Prophylactic atropine administration attenuates the negative haemodynamic effects of induction of anaesthesia with propofol and high-dose remifentanil: A randomised controlled trial.

BACKGROUND: Induction of anaesthesia with propofol and remifentanil often induces unwanted bradycardia and hypotension, raising concerns regarding tissue oxygenation. The electrophysiological cardiac effects of remifentanil can be reversed by atropine. OBJECTIVE: To investigate if prophylactic administration of atropine can attenuate the negative haemodynamic effects of propofol and a high dose of remifentanil during induction of anaesthesia. DESIGN: A double-blind, randomised controlled trial. SETTING: Single-centre, University Medical Center Groningen, The Netherlands. PATIENTS: Sixty euvolaemic patients scheduled for surgery under general anaesthesia. INTERVENTIONS: Anaesthesia was induced and maintained with a target-controlled infusion of propofol with a target effect-site concentration (Ce) of 2.5 [mu]g ml-1, remifentanil (target-controlled infusion), (Ce 8 ng ml-1) and cis-atracurium. Methylatropine (500 [mu]g) or 0.9% saline was administered at immediately before induction of anaesthesia. MAIN OUTCOME MEASURES: The changes ([DELTA]) in mean arterial pressure (MAP), heart rate (HR), cardiac index (CI), rate pressure product, cerebral tissue oxygenation and peripheral tissue oxygenation between induction of anaesthesia (T0) and 10 min later (T10). RESULTS: Atropine significantly attenuated the changes in the outcome measures between T0 and T10. Median (inter-quartile range) changes were MAP, [DELTA] = -24 (-40 to -21) vs. [DELTA] = -37 mmHg (-41 to -31) (P = 0.02); HR, [DELTA] = 0 +/- 13 vs. -19 +/- 11 bpm (P

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Effects of different fresh gas flows with or without a heat and moisture exchanger on inhaled gas humidity in adults undergoing general anaesthesia: A systematic review and meta-analysis of randomised controlled trials.

BACKGROUND: The minimum inhaled gas absolute humidity level is 20 mgH2O l-1 for short-duration use in general anaesthesia and 30 mgH2O l-1 for long-duration use in intensive care to avoid respiratory tract dehydration. OBJECTIVE: The aim is to compare the effects of different fresh gas flows (FGFs) through a circle rebreathing system with or without a heat and moisture exchanger (HME) on inhaled gas absolute humidity in adults undergoing general anaesthesia. DESIGN: Systematic review and meta-analyses of randomised controlled trials. We defined FGF (l min-1) as minimal (0.25 to 0.5), low (0.6 to 1.0) or high (>=2). We extracted the inhaled gas absolute humidity data at 60 and 120 min after connection of the patient to the breathing circuit. The effect size is expressed as the mean differences and corresponding 95% confidence intervals (CI). DATA SOURCES: PubMed, EMBASE, SciELO, LILACS and CENTRAL until January 2016. RESULTS: We included 10 studies. The inhaled gas absolute humidity was higher with minimal flow compared with low flow at 120 min [mean differences 2.51 (95%CI: 0.32 to 4.70); P = 0.02] but not at 60 min [mean differences 2.95 (95%CI: -0.95 to 6.84); P = 0.14], and higher with low flow compared with high flow at 120 min [mean differences 7.19 (95%CI: 4.53 to 9.86); P

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The epigenetic mechanism for discordance of autoimmunity in monozygotic twins

Publication date: Available online 12 April 2017
Source:Journal of Autoimmunity
Author(s): Zhongyuan Xiang, Yuanqing Yang, Christopher Chang, Qianjin Lu
Monozygotic twins share an identical DNA sequence but are not truly "identical". In fact, when it comes to health and disease, they may often display some level of phenotypic discordance. The cause of this discordance is often unknown. Epigenetic modifications such as DNA methylation, histone modification, and microRNAs-mediated regulation regulate gene expression and are sensitive to external stimuli. These modifications may be seen to bridge the gap between genetics and the environment. Over the years, the importance of epigenetics as a primary mechanism for the role that the environment plays in defining phenotype has been increasingly appreciated. Mechanisms of epigenetics include DNA methylation, histone modifications and microRNAs. Discordance rates in monozygotic twins vary depending on the specific condition, from 11% in SLE to 64% in psoriasis and 77% in PBC. Other autoimmune diseases in which discordance is found among monozygotic twins has also been studied include type 1 diabetes, multiple sclerosis, rheumatoid arthritis, dermatomyositis and systemic sclerosis. In some cases, the differences in various epigenetic modifications is slight, even though the concordance rate is low, suggesting that epigenetics is not the only factor that needs to be considered. Nonetheless, the study of phenotypic discordance in monozygotic twins may shed light on the pathogenesis of autoimmune diseases and contribute to the development of new methodologies for the diagnosis and treatment of these diseases.



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Antimicrobial and anti-inflammatory activities, wound-healing effectiveness and chemical characterization of the latex of Jatropha neopauciflora Pax

Publication date: 23 May 2017
Source:Journal of Ethnopharmacology, Volume 204
Author(s): A.B. Hernandez-Hernandez, F.J. Alarcon-Aguilar, J.C. Almanza-Perez, O. Nieto-Yañez, J.M. Olivares-Sanchez, A. Duran-Diaz, M.A. Rodriguez-Monroy, M.M. Canales-Martinez
Ethnopharmacological relevanceJatropha neopauciflora Pax is an endemic species to Mexico, and its latex is used in traditional medicine to treat mouth infections when there are loose teeth and to heal wounds. In this research, we evaluated the antimicrobial activity, wound healing efficacy and chemical characterization of J. neopauciflora latex in a murine model.Materials and methodsThe antibacterial activity was determined using Gram positive and negative strains, the antifungal activity was determined using yeast and filamentous fungi, and the wound healing efficacy of the latex was determined using the tensiometric method. The anti-inflammatory activity was evaluated using the plantar oedema model in rats, administering the latex orally and topically. Cytotoxic activity was determined in vitro in two different cell lines. Antioxidant capacity, total phenolics, total flavonoids, reducing carbohydrates and latex proteins were quantified. The latex analysis was performed by High Performance Liquid Chromatography (HPLC). Finally, molecular exclusion chromatography was performed.ResultsThe latex demonstrated antibacterial activity. The most sensitive strains were Gram positive bacteria, particularly S. aureus (MIC=2mg/mL), and the latex had bacteriostatic activity. The latex did not show antifungal activity. The latex demonstrated a wound-healing efficacy, even the positive control (Recoveron). The orally administered latex demonstrated the best anti-inflammatory activity and was not toxic to either of the 2 cell lines. The latex had a high antioxidant capacity (SA50=5.4µg/mL), directly related to the total phenolic (6.9mg GAE/mL) and flavonoid (12.53µg QE/mL) concentration. The carbohydrate concentration was 18.52µg/mL, and fructose was the most abundantly expressed carbohydrate in the latex (14.63µg/mL, 79.03%). Additionally, the latex contained proteins (7.62µg/mL) in its chemical constitution. As secondary metabolites, the HPLC analysis indicated the presence of phenols and flavonoids.ConclusionsThe J. neopauciflora latex promotes the wound healing process by avoiding microorganism infections, inhibiting inflammation and acting as an antioxidant.

Graphical abstract

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Paeoniflorin and liquiritin, two major constituents in Chinese herbal formulas used to treat hyperprolactinemia-associated disorders, inhibits prolactin secretion in prolactinoma cells by different mechanisms

Publication date: 23 May 2017
Source:Journal of Ethnopharmacology, Volume 204
Author(s): Yuanyi Wei, Lei La, Lili Wang, Robert Batey, Chunxia Wang, Yuhao Li
Ethnopharmacological relevancePaeoniflorin and liquiritin are major constituents in some Chinese herbal formulas, such as Yiru Tiaojing (YRTJ) Granule (a hospitalized preparation) and Peony-Glycyrrhiza Decoction, used for hyperprolactinemia-associated disorders.Aim of the studyTo investigate the effect of paeoniflorin and liquiritin on prolactin secretion.Materials and methodsThe effect of YRTJ Granule on metoclopramide-induced hyperprolactinemia was tested in rats. Paeoniflorin and liquiritin in the YRTJ Granule extract were identified and quantified by HPLC. The effects of paeoniflorin and liquiritin on prolactin secretion were examined in prolactinoma cells that were identified morphologically and by Western blot. The concentration of prolactin was determined by ELISA. The gene expression was analyzed by Western blot.ResultsYRTJ Granule ameliorated metoclopramide-induced hyperprolactinemia in rats. The contents of paeoniflorin and liquiritin in YRTJ Granule were 7.43 and 2.05mg/g extract, respectively. Paeoniflorin, liquiritin and bromocriptine (a dopamine D2 receptor (D2R) agonist) decreased prolactin concentration in MMQ cells expressing D2R. However, the effect of liquiritin and bromocriptine was abolished in GH3 cells lacking D2R expression. Interestingly, paeoniflorin still decreased prolactin concentration in GH3 cells in the same manner. Furthermore, paeoniflorin suppressed prolactin protein expression, and was without effect on D2R protein expression in both MMQ and GH3 cells.ConclusionsThe present results suggest that paeoniflorin and liquiritin play a role in YRTJ Granule-elicited improvement of hyperprolactinemia. While the effect of liquiritin is D2R-dependent, paeoniflorin D2R-independently inhibits prolactin secretion in prolactinoma cells that may especially benefit the hyperprolactinemic patients who are refractory to dopaminergic therapies.

Graphical abstract

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Effects of Gnaphalium affine D. Don on hyperuricemia and acute gouty arthritis

Publication date: 5 May 2017
Source:Journal of Ethnopharmacology, Volume 203
Author(s): Hong-jian Zhang, Ling-nan Li, Jie Zhou, Qin-qin Yang, Pei-gang Liu, Pan Xu, Wei-qing Liang, Lin Cheng, Ying-qi Zhang, Jin-bao Pu, Yi-juan Hu
Ethnopharmacological relevanceThe Gnaphalium affine D. Don is used in China as a folk medicine to treat gout, anti-inflammatory, antitussive and expectorant activities. The aim of this study was to evaluate the potential of the extract of G. affine to treat hyperuricemia and acute gouty arthritis in animal model.Materials and methodsG. affine extract was evaluated in an experimental model with potassium oxonate (PO) induced hyperuricemia in mice which was used to evaluate anti-hyperuricemia activity and xanthine oxidase (XO) inhibition. Therapies for acute gouty arthritis was also investigated on monosodium urate (MSU) crystal induced paw edema model.ResultsG. affine extract showed expressive results on active in reducing serum uric acid (Sur) through effect renal mGLUT9 and mURAT1 mainly and inhibit XO activity in vivo. The extract of G. affine also showed significant anti-inflammatory activity and reduced the paw swelling on MSU crystal-induced paw edema model. Meanwhile, eight major compounds were identified by HPLC-ESI-QTOF-MS/MS.ConclusionsThe extract of G. affine showed significant effect on evaluated models and therefore may be active agents for the treatment of hyperuricemia and acute gouty arthritis.

Graphical abstract

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An overview on Leucosidea sericea Eckl. & Zeyh.: A multi-purpose tree with potential as a phytomedicine

Publication date: 5 May 2017
Source:Journal of Ethnopharmacology, Volume 203
Author(s): Tshepiso C. Mafole, Adeyemi O. Aremu, Thandekile Mthethwa, Mack Moyo
Ethnopharmacological relevanceLeucosidea sericea (the sole species in this genus) is a tree species found in southern Africa and possesses several therapeutical effects against infectious diseases in humans and livestock. This review aims to document and summarize the botany, phytochemical and biological properties of Leucosidea sericea.Materials and methodsUsing the term 'Leucosidea sericea', we systematically searched literature including library catalogues, academic dissertations and databases such as PubMed, SciFinder, Web of Science, Google Scholar and Wanfang. Taxonomy of the species was validated using 'The Plant List' (www.theplantlist.org).ResultsLeucosidea sericea remains a widely used species among the different ethnic groups in southern Africa. The species is a rich source of approximately 50 essential oils and different classes of phytochemicals (phenolics, phloroglucinols, cholestane triterpenoids, alkaloids and saponins) which may account for their diverse biological properties. Documented biological activities which were mainly observed under in vitro systems included antimicrobial, anti-parasitic, antioxidant, acetylcholinesterase (AChE) inhibition and anti-inflammatory properties. Preliminary safety tests on Leucosidea sericea extracts suggest moderate cytotoxic effects based on a few cell lines that were investigated.ConclusionsLeucosidea sericea possesses diverse medicinal potential with the antimicrobial, anti-parasitic, antioxidant and anti-inflammatory activities being the most prominent. The relative abundance and tendency of Leucosidea sericea to evade in nature suggest an abundant reservoir of raw materials for potential commercialization (upon validation of its pharmacological potential). However, more stringent investigations on the extracts (and isolated bioactive compounds) focusing on the mode of actions, which will inevitably unravel their pharmacokinetics, pharmacodynamics and clinical relevance remain pertinent.

Graphical abstract

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Scholar : Ειδοποίηση Μελετητή - [ Undersea

Ειδοποίηση Μελετητή:[ Undersea "Hyperbaric Medicine" ]

The Science of Diving: Practical and Theoritical Knowledge

C Balestra, P Germonpré - 2017

[PDF] World as it is

G Uzun, M Mutluoglu, S Metin - Diving and Hyperbaric Medicine

... Undersea Hyperb Med. 2011; 38: 137-42. ... European Journal of Underwater and Hyperbaric
Medicine. 2007; 8: 35. 21 Desloovere C, Knecht R, Germonpré P. Hyperbaric oxygen therapy
after failure of conventional therapy for sudden deafness. B-ENT. ...

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Scholar : Ειδοποίηση Μελετητή - [ CPAP ]

Ειδοποίηση Μελετητή:[ CPAP ]

PRESSURE CONTROLLED EXHAUST VENT

BJ Huddart, APM Salmon, MJ Pedersen, HJ Rose… - US Patent 20,170,087,329, 2017

... A61M16/20; A61M16/22; A61M16/06; F16K15/14. Claims: 1. A valve for use with system for
delivering CPAP therapy, the valve comprising a base and a membrane, the membrane having
a first end defining an inlet opening, the base having a second end defining an outlet ...

[PDF] Associação entre Apneia Obstrutiva do Sono e Infarto do Miocárdio: Uma Revisão Sistemática

F Porto, YS Sakamoto, C Salles - Arq Bras Cardiol, 2017

... O objetivo proposto por Marin et al.7 foi comparar a incidência de eventos cardiovasculares fatais
e não-fatais em roncadores simples, pacientes com AOS não tratada, tratados com pressão
contínua positiva nas vias aéreas (CPAP) e homens saudáveis recrutados entre a ...

BREATHING ASSISTANCE APPARATUS

CK White, JP Van Beurden, KP O'donnell - US Patent 20,170,087,325, 2017

... The NASALAIRE™ creates a physical seal between the nares and itself, and relies on the
absence of leaks around itself and the nares to deliver pressure supplied by a continuous
positive airway pressure (CPAP) blower to the airway of the wearer. ...

BREATHING ASSISTANCE APPARATUS

CK White, JP Van Beurden, KP O'donnell - US Patent 20,170,087,323, 2017

... The NASALAIRE™ creates a physical seal between the nares and itself, and relies on the
absence of leaks around itself and the nares to deliver pressure supplied by a continuous
positive airway pressure (CPAP) blower to the airway of the wearer. ...

While Isolated Periodic Limb Movement Disorder Significantly Impacts Sleep Depth and Efficiency, Co-Morbid Restless Leg Syndrome Mainly Exacerbates Perceived …

FXH De Buisseret, O Mairesse, J Newell, P Verbanck… - European Neurology, 2017

... Good sleeper controls (GSC), total recording time (TRT), continuous positive airway pressure
(CPAP), periodic limb movements during sleep (PLMS), PLMS index per hour of sleep (PLMSI),
periodic limb movement disorder (PLMD), restless legs syndrome (RLS), international ...

ANMF Vic Branch Health and Environmental Sustainability Conference 28 April, Melbourne Convention and Exhibition Centre, Vic.

VV Action, A Day

... www.mcafhna.org.au/ Lung Health Promotion Centre at The Alfred Theory & Practice of Non
Invasive Ventilation (Bi-Level & CPAP Management) 1 June Spirometry Principles & Practice
5-6 June Paediatric Respiratory Update 26 June P: (03) 9076 2382 E: lunghealth@alfred ...

[PDF] This is the author's final version of the contribution published as

A Kuzenko, S Sciascia, E Silvestro, I Badiu, M Morsolini… - RHEUMATOLOGY …

... PEA and 40 min during left PEA). The patient's course was uneventful, he was weaned
from mechanical ventilation on postoperative day 1, and cycles of helmet cPAP were
performed. The patient was discharged from the ICU ...

Assessing and Treating Sexual Problems in an Integrated Care Environment

KM POLLOCK, AM ALTMAN - Integrating Behavioral Health and Primary Care, 2017

Nurses role in advanced secretion clearance

MRCH Portal

... Tracheostomy management Artificial airway suctioning *intranet only Continuous Positive Airway
Pressure (CPAP) and Non-invasive Ventilation (NIV) Non-invasive respiratory support in PICU
guideline *intranet only Nursing management of the patient with invasive mechanical ...

[PDF] Kraniofaciální abnormity při spánkovém apnoickém syndromu

S Dostálová - 2017

Page 1. Page 2. Dizertační práce byla vypracována v rámci postgraduálního doktorského studia
biomediciny, oborová rada neurověd, předseda prof. MUDr. Karel Šonka, DrSc. Autor:
MUDr.Simona Dostálová Pracoviště: Neurologická klinika 1. LF UK a VFN Praha ...

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Scholar : Ειδοποίηση Μελετητή - [ ΣΤΟΜΑ

Ειδοποίηση Μελετητή:[ ΣΤΟΜΑΤΙΤΙΣ ]

Antimicrobial Activity of the Leaf and Flower Extracts of Peltophorum Pterocarpum

D Gorai - Universal Journal of Chemistry (UJC), 2017

... Different parts of this tree are found to be used to treat many diseases like stomatitis,
insomnia, skin troubles, constipation, ringworm. Its bark is used as medicine for
dysentery, as eye lotion, embrocation for pains and sores. ...

[HTML] A role for glycolipid biosynthesis in severe fever with thrombocytopenia syndrome virus entry

MJ Drake, B Brennan, K Briley Jr, SM Bart, E Sherman… - PLoS pathogens, 2017

... Approximately 75 million mutagenized HAP1 cells were infected with a recombinant vesicular
stomatitis virus (VSV) encoding the glycoprotein of SFTSV (strain HB29, rVSV-SFTSV) in place
of VSV G. Challenge of non-mutagenized HAP1 cells with rVSV-SFTSV or mutagenized ...

11 Decontamination of Multiple-Metal

S Tharmalingam, A Alhasawi, VP Appanna… - Handbook of Metal-Microbe …, 2017

THERAPY FOR FILOVIRUS INFECTION

JR Lai, JF Koellhoffer, J Frei, K Chandran, S Sidhu… - US Patent 20,170,088,606, 2017

... Head-to-head comparison in neutralizations assays using a vesicular stomatitis virus pseudotype
(VSV-GP) with KZ52 (against ZEBOV GP, GP ZEBOV ) and 16F6 (against SUDV GP, GP SUDV )
indicates that 16F6 can reduce infectivity by at least 10-fold more than KZ52 at ...

[HTML] Lead Poisoning: A Persistent health Hazard-General and oral aspects

S Saeed, S Hasan, P Choudhury - Biomedical and Pharmacology Journal, 2017

... Oral manifestations are usually seen in chronic lead poisoning. Ulcerative stomatitis, sialorrhea
with swelling of the salivary glands, dysphagia, metallic taste,coated tongue, tremors of the tongue
on extension, [9] and gray spots on the buccal mucosaare the salient features. ...

Minimal Standards for Reporting microRNA: Target Interactions

K Piletič, T Kunej - OMICS: A Journal of Integrative Biology, 2017

... Number of MTIs More than 500,000 2705 366,181 Collecting exact genomic location of MTI / /
X Species: 32 Number of species 28 9 21 Vesicular stomatitis Indiana virus X KSHV/HHV-8 X
X Epstein Barr virus X X Human cytomegalovirus X HIV 1 X X Physcomitrella patens X ...

[PDF] Senecavirus A: Epidemiology, Pathogenesis and Infection Dynamics

LR Joshi

... VI Virus isolation VSV Vesicular stomatitis virus Page 13. xii ABSTRACT ... The lesions caused by
SVA are similar to those caused by other reportable vesicular disease causing agents of swine,
including FMDV, swine vesicular disease virus (SVDV), vesicular stomatitis virus ...

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