Automatic multimodal detection for long-term seizure documentation in epilepsy

Publication date: August 2017
Source:Clinical Neurophysiology, Volume 128, Issue 8
Author(s): F. Fürbass, S. Kampusch, E. Kaniusas, J. Koren, S. Pirker, R. Hopfengärtner, H. Stefan, T. Kluge, C. Baumgartner
ObjectiveThis study investigated sensitivity and false detection rate of a multimodal automatic seizure detection algorithm and the applicability to reduced electrode montages for long-term seizure documentation in epilepsy patients.MethodsAn automatic seizure detection algorithm based on EEG, EMG, and ECG signals was developed. EEG/ECG recordings of 92 patients from two epilepsy monitoring units including 494 seizures were used to assess detection performance. EMG data were extracted by bandpass filtering of EEG signals. Sensitivity and false detection rate were evaluated for each signal modality and for reduced electrode montages.ResultsAll focal seizures evolving to bilateral tonic-clonic (BTCS, n=50) and 89% of focal seizures (FS, n=139) were detected. Average sensitivity in temporal lobe epilepsy (TLE) patients was 94% and 74% in extratemporal lobe epilepsy (XTLE) patients. Overall detection sensitivity was 86%. Average false detection rate was 12.8 false detections in 24h (FD/24h) for TLE and 22 FD/24h in XTLE patients. Utilization of 8 frontal and temporal electrodes reduced average sensitivity from 86% to 81%.ConclusionOur automatic multimodal seizure detection algorithm shows high sensitivity with full and reduced electrode montages.SignificanceEvaluation of different signal modalities and electrode montages paces the way for semi-automatic seizure documentation systems.



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Brain network dynamics in the human articulatory loop

Publication date: August 2017
Source:Clinical Neurophysiology, Volume 128, Issue 8
Author(s): Masaaki Nishida, Anna Korzeniewska, Nathan E. Crone, Goichiro Toyoda, Yasuo Nakai, Noa Ofen, Erik C. Brown, Eishi Asano
ObjectiveThe articulatory loop is a fundamental component of language function, involved in the short-term buffer of auditory information followed by its vocal reproduction. We characterized the network dynamics of the human articulatory loop, using invasive recording and stimulation.MethodsWe measured high-gamma activity70–110 Hz recorded intracranially when patients with epilepsy either only listened to, or listened to and then reproduced two successive tones by humming. We also conducted network analyses, and analyzed behavioral responses to cortical stimulation.ResultsPresentation of the initial tone elicited high-gamma augmentation bilaterally in the superior-temporal gyrus (STG) within 40ms, and in the precentral and inferior-frontal gyri (PCG and IFG) within 160ms after sound onset. During presentation of the second tone, high-gamma augmentation was reduced in STG but enhanced in IFG. The task requiring tone reproduction further enhanced high-gamma augmentation in PCG during and after sound presentation. Event-related causality (ERC) analysis revealed dominant flows within STG immediately after sound onset, followed by reciprocal interactions involving PCG and IFG. Measurement of cortico-cortical evoked-potentials (CCEPs) confirmed connectivity between distant high-gamma sites in the articulatory loop. High-frequency stimulation of precentral high-gamma sites in either hemisphere induced speech arrest, inability to control vocalization, or forced vocalization. Vocalization of tones was accompanied by high-gamma augmentation over larger extents of PCG.ConclusionsBilateral PCG rapidly and directly receives feed-forward signals from STG, and may promptly initiate motor planning including sub-vocal rehearsal for short-term buffering of auditory stimuli. Enhanced high-gamma augmentation in IFG during presentation of the second tone may reflect high-order processing of the tone sequence.SignificanceThe articulatory loop employs sustained reciprocal propagation of neural activity across a network of cortical sites with strong neurophysiological connectivity.



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Erratum to: Temporal trends of lipophilic persistent organic pollutants in serum from Danish nulliparous pregnant women 2011–2013

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Calendar

Publication date: July 2017
Source:European Journal of Surgical Oncology (EJSO), Volume 43, Issue 7





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Pulmonary metastasectomy – A retrospective comparison of surgical outcomes after laser-assisted and conventional resection

Publication date: July 2017
Source:European Journal of Surgical Oncology (EJSO), Volume 43, Issue 7
Author(s): K. Franzke, R. Natanov, N. Zinne, T.K. Rajab, C. Biancosino, I. Zander, S. Lodziewski, M. Ricklefs, I. Kropivnitskaya, J.D. Schmitto, A. Haverich, M. Krüger
IntroductionIndications and surgical techniques for pulmonary metastasectomy (PME) are controversially discussed issues. Laser-assisted surgery (LAS) is a recent innovation that has been advocated especially in patients with multiple pulmonary metastases (PM). However, there are hardly any studies comparing surgical outcomes after laser-assisted and conventional resection. The aim of the current study was to evaluate the value of LAS in a larger study population.Materials & methodsA retrospective analysis was completed on 178 consecutive patients undergoing 236 PMEs at a single center between 2010 and 2015. The main endpoint was survival. Statistical analysis was performed using the Kaplan–Meier method and survival rates were compared with the log rank test. Follow-up was done with special attention to the development of recurrent PM. Local relapse was defined as a recurrent metastasis in direct relation to the previously resected area according to CT scan comparisons.ResultsLAS was performed on 256 metastases in 99 patients, non-laser-assisted surgery (NLAS) on 127 metastases in 79 patients. 5-year-survival rates were 69.3% in all patients, 65.7% after LAS and 73.6% after NLAS. There was no statistically significant survival difference after LAS or NLAS (p = 0.41). The rate of local relapse was 0.8% after LAS vs 3.1% after NLAS (p = 0.073).ConclusionDespite a larger number of negative predictors for survival in LAS patients, overall survival (OS) was similar in the compared groups. There was also a trend for a lower risk of local relapses after LAS. Therefore, LAS should be considered a promising method for PME.



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The evolving clinical management of cerebral metastases

Publication date: July 2017
Source:European Journal of Surgical Oncology (EJSO), Volume 43, Issue 7
Author(s): R. Sinha, W. Sage, C. Watts
Concepts in the management of brain metastases are evolving. Until recently, brain metastases have been considered as a homogenous condition, managed with whole brain radiotherapy, surgical resection for large lesions and stereotactic radiosurgery for smaller lesions. Increasingly, specific systemic medical therapies are being used to treat brain metastases based on the primary site of disease. This disease specific management is causing a change in perspective about brain metastases and has led to improved survival for patients with primary disease subtypes amenable to tailored medical therapies. We review the recent literature to present evidence for the use of subtype specific medical therapies, advances in surgical resection techniques and stereotactic radiosurgery as the primary treatment modalities. The decline in use of whole brain radiotherapy as first line treatment is also discussed. Based on the recent literature, we propose a new management algorithm to reflect the progress in available options for tailoring disease specific treatments and support the change in paradigm to consider brain metastases as separate disease states based on the primary site of cancer rather than as a homogenous entity.



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Editorial Board

Publication date: July 2017
Source:European Journal of Surgical Oncology (EJSO), Volume 43, Issue 7





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Announcements

Publication date: July 2017
Source:European Journal of Surgical Oncology (EJSO), Volume 43, Issue 7





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Prevalence of adenoid hypertrophy: a systematic review and meta-analysis

The purpose of our review was to synthesize the existing literature about the prevalence of adenoid hypertrophy in children and adolescents confirmed by the reference standard – the nasoendoscopy. Six electronic databases and grey literature were searched. Studies were included if they reported the prevalence of adenoid hypertrophy confirmed via nasoendoscopy. Studies involving participants with associated comorbidities, fully diagnosed sleep apnea in their sample were excluded. The MAStARI tool assessed the potential risk of bias (RoB) among the studies, while the GRADE approach determined the level of evidence.

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Regulatory effects of berberine on microRNome in Cancer and other conditions

Publication date: Available online 13 June 2017
Source:Critical Reviews in Oncology/Hematology
Author(s): Seyed Hasan Ayati, Badrieh Fazeli, Amir Abbas Momtazi-borojeni, Arrigo F.G. Cicero, Matteo Pirro, Amirhossein Sahebkar
Berberine (BBR) is an isoquinoline alkaloid found in different plant families such as Berberidaceae, Ranunculaceae, and Papaveraceae. BBR is well-known for its anti-inflammatory, lipid-modifying, anticancer, anti-diabetic, antibacterial, antiparasitic and fungicide activities. Multiple pharmacological actions of BBR stem from different molecular targets of this phytochemical. MicroRNAs (miRs) are single-stranded, evolutionary conserved, small non-coding RNA molecules with a length of 19–23 nucleotides that are involved in RNA silencing and post-transcriptional regulation of gene expression through binding to the 3′-untranslated region (3′UTR) of target mRNA. MiRs emerged as important regulatory elements in almost all biological processes like cell proliferation, apoptosis, differentiation and organogenesis, and numerous human diseases such as cancer and diabetes. BBR was shown to regulate the expression of miRs in several diseases. Here, we reviewed the target miRs of BBR and the relevance of their modulation for the potential treatment of serious human diseases like multiple myeloma, hepatocellular carcinoma, colorectal cancer, gastric cancer, ovarian cancer and glioblastoma. The role of miR regulation in the putative anti-diabetic effects of BBR is discussed, as well.



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Bartholin gland cancer

Publication date: Available online 13 June 2017
Source:Critical Reviews in Oncology/Hematology
Author(s): Violante Di Donato, Assunta Casorelli, Erlisa Bardhi, Flaminia Vena, Marchetti Claudia, Ludovico Muzii, Pierluigi Benedetti Panici
IntroductionBartholin gland carcinoma is an extremely rare condition. Because of its, phase III trials have not been carried out, there exists no unanimous consensus on treatment and guidelines are missing.MethodsAll studies reporting cases of Bartholin cancer were collected and screened for the evaluations. Baseline characteristics of studies were extracted and were queried in a database.ResultsA total number of 133 manuscripts collected were available for the review process, representing a total number of 275 reported cases. The histological type of Bartholin gland cancer was specified in 90.4% cases: 30.7% cases were squamous cell carcinoma, 29.6% adenoid cystic carcinoma, 25% adenocarcinomas. At multivariate analysis adenocarcinoma histotype and positive lymph node were statistical correlated with worse prognosis.ConclusionBartholin gland cancer remains a challenge for gynecologic oncologists. To better understand and treat this disease, centralization to referral centers and design of multi institutional trials is crucial.



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Erratum to: an unusual pre-ligamentous thenar motor branch of the median nerve

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The cadaveric feasibility study of using filler augmentation at the lower nose for the reinforcement of the external nasal valve

Abstract

Background

Filler injections have been used in rhinoplasty to correct minor nose deformities and to augment the nasal dorsum. At the lower nose, the procedures are used to increase nasal tip projection and improve the bulbous nasal tip but they have never been used in the correction of the lateral crus weakness and collapsed external nasal valves.

Methods

The study was conducted with 14 human cadavers that underwent lower nose injection rhinoplasty using the columellar and alar injections as tripod augmentation. The nasal alae were tunneled and retrogradely injected by a needle. The compared parameters measured to evaluate the improvement before and after the treatment were basilar nasal width, interalar width, columella-nasal tip height, columellar-labial angle, and the length and width of the nostrils. Measurements were taken with a digital caliper. All measurements were matched and compared for statistical analysis.

Results

There were seven male and seven female Thai cadavers. Most of the values of the parameters were increased, but the basilar nasal width and interalar width were not changed. The columellar-labial angle, columella-nasal tip height, and nostril's length showed statistically significant differences (P < .05), leading to positive changes in the nostril cross-sectional area, the nasal tip projection and the external nasal valve.

Conclusions

Injection rhinoplasty of the lower nose as tripod augmentation of the external nasal valve increases the nasal tip projection and the nostril cross-sectional area thus improving the functional and esthetic appearance.Level of Evidence: Not ratable.

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Neural substrates underlying balanced time perspective: A combined voxel-based morphometry and resting-state functional connectivity study

Publication date: 14 August 2017
Source:Behavioural Brain Research, Volume 332
Author(s): Yiqun Guo, Zhiyi Chen, Tingyong Feng
Balanced time perspective (BTP), which is defined as a mental ability to switch flexibly among different time perspectives Zimbardo and Boyd (1999), has been suggested to be a central component of positive psychology Boniwell and Zimbardo (2004). BTP reflects individual's cognitive flexibility towards different time frames, which leads to many positive outcomes, including positive mood, subjective wellbeing, emotional intelligence, fluid intelligence, and executive control. However, the neural basis of BTP is still unclear. To address this question, we quantified individual's deviation from the BTP (DBTP), and investigated the neural substrates of DBTP using both voxel-based morphometry (VBM) and resting-state functional connectivity (RSFC) methods VBM analysis found that DBTP scores were positively correlated with gray matter volume (GMV) in the ventral precuneus. We further found that DBTP scores were negatively associated with RSFCs between the ventral precuneus seed region and medial prefrontal cortex (mPFC), bilateral temporoparietal junction (TPJ), parahippocampa gyrus (PHG), and middle frontal gyrus (MFG). These brain regions found in both VBM and RSFC analyses are commonly considered as core nodes of the default mode network (DMN) that is known to be involved in many functions, including episodic and autobiographical memory, self-related processing, theory of mind, and imagining the future. These functions of the DMN are also essential to individuals with BTP. Taken together, we provide the first evidence for the structural and functional neural basis of BTP, and highlight the crucial role of the DMN in cultivating an individual's BTP.



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Integrating a facial scan, virtual smile design, and 3D virtual patient for treatment with CAD-CAM ceramic veneers: A clinical report

Publication date: Available online 13 June 2017
Source:The Journal of Prosthetic Dentistry
Author(s): Wei-Shao Lin, Bryan T. Harris, Kamolphob Phasuk, Daniel R. Llop, Dean Morton
This clinical report describes a digital workflow using the virtual smile design approach augmented with a static 3-dimensional (3D) virtual patient with photorealistic appearance to restore maxillary central incisors by using computer-aided design and computer-aided manufacturing (CAD-CAM) monolithic lithium disilicate ceramic veneers.



http://ift.tt/2rpgN6h

Machine Learning based Identification of Protein-Protein Interactions using derived features of physiochemical properties and Evolutionary profiles

Publication date: Available online 13 June 2017
Source:Artificial Intelligence in Medicine
Author(s): Muhammad Tahir, Maqsood Hayat
Proteins are the central constitute of a cell or biological system. Proteins execute their functions by interacting with other molecules such as RNA, DNA and other proteins. The major functionality of protein-protein interactions (PPIs) is the execution of biochemical activities in living species. Therefore, an accurate identification of PPIs becomes a challenging and demanding task for investigators from last few decades. Various traditional and computational methods have been applied but they have not achieved quite encouraging results. In order to extend the concept of computational model by incorporating intelligent, contemporary machine learning algorithms have been utilized for identification of PPIs. In this prediction model, protein sequences are expressed by using two distinct feature extraction methods namely: physiochemical properties of amino acids and evolutionary profiles method position specific scoring matrix (PSSM). Jackknife test and numerous performance parameters namely: specificity, recall, accuracy, MCC, precision, and F-measure were employed to compute the predictive quality of proposed model. After empirical analysis, it is determined that the proposed prediction model yielded encouraging predictive outcomes compared to existing state-of-the-art models. This achievement is ascribed with PSSM because it has clearly discerned a motif of PPIs. It is realized that the proposed prediction model will lead to be a practical and very useful tool for research community.



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Attitudes towards menopause and depression, body image of women during menopause

Publication date: Available online 13 June 2017
Source:Alexandria Journal of Medicine
Author(s): Nülüfer Erbil




http://ift.tt/2tk7r8v

Scholar : Ειδοποίηση Μελετητή - [ ΓΛΩΣΣ

Ειδοποίηση Μελετητή:[ ΓΛΩΣΣΙΤΙΣ ]

Geographic Tongue: assessment of Peripheral Nerve Status, Langerhans cell and HLA-DR Expression

MR Darling, N Su, S Masen, P Kwon, D Fortino… - Oral Surgery, Oral Medicine, …, 2017

... symptomatic in geographic tongue. Introduction. Geographic Tongue (GT) (also called
benign migratory glossitis) is a benign inflammatory disorder that affects 1% to 3%
of the population, occurring predominantly in females. 1; 2 ; 3 ...

[PDF] Fatal Herpes simplex virus 1 (HSV-1) Infection in a Group of Zoo-Kept White-Faced Saki Monkeys (Pithecia pithecia) in Israel

R Lapid, D Eshar - Israel Journal of Veterinary Medicine, 2017

... 1 infection. However, in the absence of supporting pathological findings this remains
speculative. Figure 1: Picture of the adult female saki's tongue in this report, showing
HSV lesions of the ulcerative glossitis. Figure 2: Picture ...

[HTML] Homoeopathic pathogenetic trial of Withania somnifera: A multicentric, double-blind, randomised, placebo-controlled trial

P Mehra, A Khurana, R Mittal, BS Arya, RK Manchanda… - Indian Journal of Research …, 2017

... Conventionally, W. somnifera has been used as an anti-inflammatory agent, [3],[4],[5] and in this
pathogenetic trial also, some symptoms developed which can be related to inflammatory
conditions such as burning pain in tongue (glossitis), itching and redness of left eye ...

Blackleg in cattle: A case report of fetal infection and a literature review

CC Abreu, EE Edwards, JF Edwards, PM Gibbons… - Journal of Veterinary …, 2017

Clostridium chauvoei causes blackleg in cattle. The disease has been reported worldwide, and
although it can be prevented by vaccination, sporadic cases and occ.

[PDF] Anaemia in Pregnancy

K Tewary, A Singh

... Other features are palpitation, dyspnoea, giddiness, pedal oedema and rarely, generalized
anasarca and even cardiac failure in severe cases. Signs- Pallor of varying degree, glossitis,
stomatitis, oedema of the legs due to hypoproteinaemia. ...

Nicotine Upregulates Coaggregation of Candida albicans and Streptococcus mutans

A Ashkanane, GF Gomez, J Levon, LJ Windsor… - Journal of Prosthodontics

... Examples of primary oral candidiasis are: pseudomembranous candidiasis, erythematous
candidiasis, denture stomatitis (the focus of this study), angular cheilitis, median rhomboid
glossitis, leukoplakia, lichen planus, and lupus erythematosus. ...

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Scholar : Ειδοποίηση Μελετητή - [ Laryngotra

Ειδοποίηση Μελετητή:[ Laryngotracheal reconstruction ]

[PDF] Colopharyngoplasty in Patients with Severe Pharyngoesophageal Corrosive Injury: A Complicated but Worthwhile Procedure to Restore GI Tract Continuity, A Case …

M Zangi, SR Saghebi, AB Monfared, S Lajevardi… - Tanaffos, 2017

... Both cases required laryngotracheal dissociation due to recurrent episodes of aspiration
pneumonia, which could not be prevented by tracheostomy alone. ... Four patients in the
present study experienced dysphagia after reconstruction. ...

[PDF] Item Selection and Content Validity of the Risk Factors of Post-Intubation Tracheal Stenosis Observation Questionnaire for ICU-Admitted Patients

R Farzanegan, B Farzanegan, M Alehashem, M Zangi… - Tanaffos, 2017

... Background: Laryngotracheal stenosis as a late complication of prolonged endotracheal
intubation is a life-threatening event. ... Ultimately, in most cases, tracheal resection and
reconstruction would be required for optimal treatment (14). ...

Practical Imaging Evaluation of Foreign Bodies in Children: An Update

BF Laya, R Restrepo, EY Lee - Radiologic Clinics of North America, 2017

... become more valuable by virtue of its wide availability; high resolution; and the multiplanar,
3-dimensional (3D), and other image reconstruction capabilities. ... 1) only 10% of all airway FBs
are radiopaque, 18; 29 ; 30 (2) up to 80% of children with laryngotracheal foreign bodies ...

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Scholar : Ειδοποίηση Μελετητή - [ ΛΑΡΥΓ

Ειδοποίηση Μελετητή:[ ΛΑΡΥΓΓΙΚΟ ΝΕΥΡΟ ]

[PDF] Διαταραχές φωνής σε εκπαιδευτικούς

Ε Βοϊτσίδου - 2017

... Κατά την κατάποση, η μεγάλη κινητικότητα του ευνοεί τη σύγκλιση της λαρυγγικής οδού και τη ...
άνω και κάτω (παλίνδρομου) λαρυγγικού νεύρου, ψευδοπρομηκική/προμηκική παράλυση, ... Οι
ασθένειες του λάρυγγα (diseases of larynx), που αφορούν αμιγώς λαρυγγικές ασθένειες ...

[PDF] Επιπτώσεις της Εργασίας στα Χαρακτηριστικά Φωνής Γυναικών

Α Χουλέβα, Ε Τοπάλογλου - 2017

... Η ομαλή παραγωγή φωνής εξαρτάται από την ισχύ και την ροή αέρα που παράγεται από το
αναπνευστικό σύστημα, τη λαρυγγική μυϊκή δύναμη, την ισορροπία, τον συντονισμό ... o Παράλυση
παλίνδρομου λαρυγγικού νεύρου ... Λαρυγγικές ασθένειες o Φλεγμονή του λάρυγγα ( π.χ. ...

[PDF] Ψυχογενείς διαταραχές φώνησης & χαρακτηριστικά προσωπικότητας

ΑΡ Καρανικόλα - 2017

... παλίνδρομου λαρυγγικού νεύρου, το οποίο ευθύνεται για την κίνηση των φωνητικών χορδών. ... ή
περισσότερα λαρυγγικά σύνολα μυών είναι υπερδραστήρια, με αποτέλεσμα τη φωνητική κόπωση. ...
συμβάλλουν στην έναρξη και διαιώνιση της υπερβολικής λαρυγγικής έντασης. ...

[PDF] Μελέτη περίπτωσης παιδιού ηλικίας 8 ετών με διαταραχή ομιλίας: Αξιολόγηση μέσω του ερωτηματολογίου του Achenbach και παρέμβαση στον τομέα της άρθρωσης με …

Χ Τάρε - 2017

... άρθρωσης, φώνησης και προσωδίας λόγω διαταραχή των μυών και των νεύρων Οι διαταραχές
του λόγου είναι : ... Η παραγωγή της ομιλίας απαιτεί κοινή προσπάθεια τριών συστημάτων
αναπνευστικό, λαρυγγικό, και αρθρωτικό. Το αναπνευστικό σύστημα παρέχει την στοιχειώδη ...

[PDF] Διαταραχή άρθρωσης των φωνημάτων/r/,/s/και θεραπευτική παρέμβαση.

Β Βραχιώλη, Λ Δεμπούδη, Π Δρουγουνάκη… - 2017

Page 1. 0 ΠΤΥΧΙΑΚΗ ΕΡΓΑΣΙΑ ΤΕΙ ΗΠΕΙΡΟΥ ΣΧΟΛΗ ΕΠΑΓΓΕΛΜΑΤΩΝ ΥΓΕΙΑΣ ΚΑΙ ΠΡΟΝΟΙΑΣ
ΤΜΗΜΑ ΛΟΓΟΘΕΡΑΠΕΙΑΣ ΕΠΙΒΛΕΠΟΥΣΑ ΚΑΘΗΓΗΤΡΙΑ: ΜΕΛΙΝΑ ΝΗΣΙΩΤΗ ΙΩΑΝΝΙΝΑ 2016
Διαταραχή άρθρωσης των φωνημάτων /r/, /s/ και θεραπευτική παρέμβαση ...

[PDF] Αρθρωτικές-φωνολογικές διαταραχές, φωνολογική καθυστέρηση.

Α Δαλακλή, Ε Καραγεωργού - 2017

... 1.5.5 Φωνητική – Φωνολογία Ο ανθρώπινος οργανισμός είναι ικανός να παράγει μεγάλο αριθμό
ήχων χρησιμοποιώντας το αναπνευστικό σύστημα, καθώς επίσης και τις διάφορες ανατομικές
δομές που εδρεύουν στη λαρυγγική, τη φαρυγγική, τη στοματική και τη ρινική κοιλότητα. ...

[PDF] Φωνολογική διαταραχή και Παρουσίαση περιστατικού με φωνολογική διαταραχή.

Γ Κολόκα, Μ Κοντογεωργίου - 2017

... 8 την περίοδο αυτήν παρατηρείται μια διαφοροποίηση της αρχικής φωνολογικής παραγωγής
του παιδιού, που χαρακτηρίζεται από ένα γενικότερο λαρυγγικό ηχητικό παιχνίδι, συνήθως
αναδιπλασιαζόμενων συλλαβών του τύπου [gangang] και αναγνωρίζεται ως ο πρώτος σταθμός ...

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