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Σάββατο 25 Μαρτίου 2017

Tsunami run-up and inundation along the coast of Sabah and Sarawak, Malaysia due to a potential Brunei submarine mass failure

Abstract

Submarine landslides, also known as submarine mass failures (SMFs), are major natural marine disasters that could critically damage coastal facilities such as nuclear power plants and oil and gas platforms. It is therefore essential to investigate submarine landslides for potential tsunami hazard assessment. Three-dimensional seismic data from offshore Brunei have revealed a giant seabed mass deposited by a previous SMF. The submarine mass extends over 120 km from the continental slope of the Baram Canyon at 200 m water depth to the deep basin floor of the Northwest Borneo Trough. A suite of in-house two-dimensional depth-averaged tsunami simulation model TUNA (Tsunami-tracking Utilities and Application) is developed to assess the vulnerability of coastal communities in Sabah and Sarawak subject to potential SMF tsunami. The submarine slide is modeled as a rigid body moving along a planar slope with the center of mass motion parallel to the planar slope and subject to external forces due to added mass, gravity, and dissipation. The nonlinear shallow water equations are utilized to simulate tsunami propagation from deepwater up to the shallow offshore areas. A wetting-drying algorithm is used when a tsunami wave reaches the shoreline to compute run up of tsunami along the shoreline. Run-up wave height and inundation maps are provided for seven densely populated locations in Sabah and Sarawak to highlight potential risks at each location, subject to two scenarios of slide slopes: 2° and 4°. The first wave may arrive at Kudat as early as 0.4 h after the SMF, giving local communities little time to evacuate. Over a small area, maximum inundated depths reaching 20.3 m at Kudat, 26.1 m at Kota Kinabalu, and 15.5 m at Miri are projected, while the maximum inundation distance of 4.86 km is expected at Miri due to its low-lying coast. In view of the vulnerability of some locations to the SMF tsunami, it is important to develop and implement community resilience program to reduce the potential damage that could be inflicted by SMF tsunamis.



http://ift.tt/2nSEDVq

Characterization of PM 2.5 chemical composition at the Demokritos suburban station, in Athens Greece. The influence of Saharan dust

Abstract

The aim of this work is to study the atmospheric concentrations of selected major and trace elements and ions found in PM2.5, at a suburban site in Athens, Greece, and discuss on the impact of the different sources. Special focus is given to the influence of Saharan dust episodes. The seasonal variability in the metal and ion concentrations is also examined. The results show that PM2.5 mass concentrations are significantly influenced by Saharan dust events; it is observed that when the PM2.5 concentration is higher than 25 μg/m3, five out of six times, the air mass crossed North Africa at an altitude within the boundary layer. Fe is found to be the element with the more significant seasonal variability, displaying much higher concentrations during cold period. The frequent Saharan dust intrusions in the cold period of this dataset may explain this result. Mineral dust and secondary aerosol are the main PM2.5 components (29 and 34%, respectively). During Saharan dust events, the concentration of mineral dust is increased by 35% compared to the days without dust intrusions, while an increase of 68% of the sea salt is also observed. During event days, PM2.5 concentrations are also increased by 14%. Anthropogenic components do not decrease during those days, while sulfate displays even a slight increase, suggesting enrichment of mineral dust with secondary sulfates. The results indicate that African dust intrusions add a rather significant PM pollution load even in the PM2.5 fraction, with implication to population exposure and human health.



http://ift.tt/2njl2e8

Expression of the cyanobacterial enzyme cyanase increases cyanate metabolism and cyanate tolerance in Arabidopsis

Abstract

Cyanate and its derivatives are considered as environmental hazardous materials. Cyanate is released to the environment through many chemical industries and mining wastewater. Cyanase enzyme converts cyanate into CO2 and NH3 in a bicarbonate-dependent reaction. At low cyanate concentrations, the endogenous plant cyanases play a vital role in cyanate detoxification. However, such cyanate biodegradation system is probably insufficient due to the excess cyanate concentrations at contaminated sites. In this study, we have transferred the activity of the cyanobacterial cyanase into Arabidopsis thaliana plants in order to enhance plant resistance against cyanate toxicity. The enzyme was shown to be active in planta. Transgenic plants exposed to cyanate, either applied by foliar spray or supplemented in growth medium, showed less reduction in pigment contents, antioxidant enzymes, carbohydrate contents, and reduced levels of plant growth retardation. Plant growth assays under cyanate stress showed enhanced growth and biomass accumulation in cyanase overexpressors compared to control plants. Results of this study provide evidence for developing novel eco-friendly phytoremediation systems for cyanate detoxification.



http://ift.tt/2nSDNbd

Quality Survival with Fertility after Gynaecological and other Cancers

Introduction: Earlier, diagnosis of cancer ultimately led to death but now with complex therapies, not only many survive, but they have quality life too. Even preservation of fertility is possible. In addition to this, with early diagnosis, complete cure is possible. <p></p> Objectives: To look into the existing evidence, challenges and possibilities. <p></p> Methodology: Simple review of literature was done with the help of various search engines, Pubmed, Google, Uptodate and other databases to evaluate the relevant studies, reviews and short commentaries to get information as per the objectives. <p></p> Evidence: Because of long-term effects of various cancers and their therapies, problems like quality of life, sexuality and fertility are the real concerns. Gonadal dysfunction is common, especially in gynaecological cancers and their therapies. Germ cell tumors of ovary are most common in young girls but with conservative surgery and chemotherapy the results are excellent. Same is true even for stage I epithelial ovarian cancers. Conservative therapies for cervical cancer, conization, simple / radical trachelectomy can do wonders. Endometrial cancer usually occurs after menopause, and there are no standard recommendations for conservative management, which is possible in younger women. Choriocarcinoma is highly malignant but has high cure rate too. So, quality survival is possible. Studies with Breast cancer, Hodgkin lymphoma have also revealed menstrual function resumption after chemotherapy. Presurgery assessment and close follow-up are necessary. Side effects of radiochemotherapy are real. Effects are drug, dose, and age dependent with possibilities of infertility and adverse pregnancy outcomes. Gonadotoxic effects may cause early menopause. Challenges increase if cancer occurs during pregnancy. <p></p> Preventive Possibilities and Conclusion: Mission of any cancer therapy needs to be quality long life, preservation of pregnancy prospects: natural or assisted. Prepubertal ovary is least susceptible to gonadotoxicity with chances of better reproductive life. Ovarian transposition / shielding or transplantation is possible. Ovarian tissue rather than oocyte or embryo cryopreservation is better. Early diagnosis and safe therapy can do miracles for women who are diagnosed with cancer. Conservative surgery, safe chemotherapy and focused radiation can reduce gonadotoxicity and preserve fertility. Multidisciplinary treatments are essential. Role of psychotherapy is important. For quality survival with reduced risk of cardiac, renal, neurological problems, bone osteoporosis and also for preservation of fertility, therapy needs proper planning for all cancers. <p></p>

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Organotin(IV) Carboxylates as Promising Potential Drug Candidates in the Field of Cancer Chemotherapy

Medicinal inorganic chemistry plays an important role in exploring the properties of metal ions for the designing of new drugs. The field has been stimulated by the success of cis-platin, the world best selling anticancer drug and platinum complexes with reduced toxicity, oral activity and activity against resistant tumors are currently on clinical trial. The use of cis-platin is, however, severely limited by its toxic side-effects. This has stimulated chemists to employ different strategies in the development of new metal-based anticancer agents with different mechanisms of action. The discovery of new non-covalent interactions with the classical target, DNA, was the first developing step in the treatment of cancer. The use of organometallic compounds as a medicine is very common now a days because it offers potential advantages over the more common organic-based drugs. In this article we have highlighted the anticancer activity of the organotin(IV) carboxylates published in the last few years (from 2008 to 2016). In most cases they present lower IC<sub>50</sub> values than those of cisplatin, which indicates their high activity against the cancer cell lines. The summarized data reveal that every year new organotin(IV) carboxylate complexes are synthesized with the aim of new anticancer agent with much better results than the than the corresponding activity of cis-platin or other clinically approved drugs. In addition to the advantages of high activity, compared to the platinum compound, tin complexes are much cheaper. Thus by using organotin carboxylate for clinical medicine, cost reduction, dosage reduction and effect enhancement will be reached.

http://ift.tt/2n676mX

Scholar : West China Journal of Stomatology, Year 2017, Issue 01 -New Issue Alert.



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We are pleased to deliver your requested table of contents alert for West China Journal of Stomatology. Year 2017 Issue 01 is now available on CAOD.


In this issue:

Difficulty influence factors of dental caries clinical treatment (龋病临床治疗难度因素及处理)
Zhou Xuedong, ,Ling Junqi, ,Liang Jingping, ,Li Jiyao, ,Cheng Lei, ,Yu Qing, ,Niu Yumei, ,Guo Bin, ,Chen Hui
...... page:1-7
guo ji kou qiang yi xue za zhi ru xuan 2016 qi kan shu zi ying xiang li 100 qiang qi kan (《国际口腔医学杂志》入选"2016期刊数字影响力100强"期刊)
GUO Jikouqiangyixuezazhibianjibu
...... page:7-7
Application of team approach and key techniques of cleft lip and palate (唇腭裂序列治疗与关键技术的应用)
Shi Bing, ,Fu Yuchuan, ,Yin Ningbei, ,Huang Hong-zhang, ,Liu Jianhua, ,Chen Renji, ,Zhu Hongping, ,Liu Qiang, ,Huang Yongqing, ,Ren Zhanping, ,Lu Yong, ,Xiao Wenlin, ,Song Qinggao, ,LiWanshan, ,Li Sheng, ,Wang Hongtao, ,Zhang Junrui, ,Jiang Liping, ,Ma Li, ,Wang Ling, ,He Dengqi
...... page:8-17
Current dental implant design and its clinical importance (当代牙种植体设计进步与临床意义)
Lin Ye
...... page:18-28
Research progress on bisphosphonate-related osteonecrosis of the jaws (双膦酸盐相关性颌骨坏死)
Pan Jian, ,Wang Qizhang, ,Liu Jiyuan
...... page:29-36
Analysis of salivary protease spectrum in chronic periodontitis (慢性牙周炎患者唾液蛋白酶谱分析)
Li Qian, ,Zhou Xuedong, ,Fan Yaping, ,Yang Tengyu, ,Wu Songtao, ,Yu Yu, ,Chen Jiao, ,Zhang Ping, ,Feng Yun
...... page:37-42
hua xi kou qiang yi xue za zhi he guo ji kou qiang yi xue za zhi guan fang wei xin gong zhong fu wu ping tai kai tong (《华西口腔医学杂志》和《国际口腔医学杂志》官方微信公众服务平台开通)
HUA Xikouqiangyixuezazhibianjibu, , Guojikouqiangyixuezazhibianjibu
...... page:42-42
Effects of different surface modifications on micro-structure and adhesion of zirconia ceramic:anin vitro study (不同表面处理方法对氧化锆陶瓷微观结构和粘接强度影响的研究)
Li Siwen, ,Li Shishi, ,Wang Yanhong, ,Ma Hongmei
...... page:43-50
Development and characterization of oriented scaffolds derived from cartilage extracellular matrix (基于软骨细胞外基质的取向支架的制备及评价)
Li Kun, ,Zhao Yanhong, ,Xu Chen, ,Wang Lianyong, ,Yang Qiang, ,Li Hongfa, ,Teng Binhong
...... page:51-56
Effect of clock gene PER1 knockdown on clock gene networks in human oral squamous cell carcinoma (沉默生物钟基因PER1对口腔鳞状细胞癌细胞中生物钟基因网络的影响)
Zhao Qin, ,Ao Yiran, ,Yang Kai, ,Su Xiaoli, ,Lü Xiaoqiang
...... page:57-62
Study of human leucine-rich amelogenin peptide and its regulation of mineralization by cryogenic transmission electron microscopy (人釉原蛋白亮氨酸富集片段的冷冻电子显微镜观察及其引导矿化性能研究)
Tian Kun, ,Feng Xiaoyun, ,Du Qin, ,Liao Chuhang, ,Ren Xiaohua
...... page:63-67
Influences of vibration on rapid osteogenic response of osteoblasts (微振动对成骨细胞成骨效应的瞬时影响)
Zhu Zhuoli, ,Zhang Ling, ,Ma Ruiyang, ,Gan Xueqi
...... page:68-72
Complications of supratemporalis approach with scalp coronal incision for orbital-zygomatic fracture (头皮冠状切口颞肌上入路治疗眶颧骨折并发症研究)
Wang Yanan, ,Huang Yanli, ,Dilnur Dilxat, ,Liu Weilong, ,Li Hui, ,Wang Yi, ,Liu Lei
...... page:73-76
Three-dimensional finite element analyses of the deep wedge-shaped defective premolars restored with different methods (不同修复方法对深型楔状缺损牙应力分布影响的三维有限元分析)
Zhao Ling, ,Yang Liyuan, ,Liu Cuiling, ,Gao Xu
...... page:77-81
Cone beam computed tomography evaluation of bifid mandibular canals in the adult population in Sichuan Province (四川地区成年人群中分叉下颌管的锥形束CT研究)
Ye Li, ,Chen Yafei, ,Pei Jun, ,Liu Yuanyuan, ,Qi Shuqun, ,Pan Jian
...... page:82-88
Research on bond durability among different core materials and zirconia ceramic cemented by self-adhesive resin cements (不同核材料与二氧化锆陶瓷树脂粘接耐久性的研究)
Luo Xinyu, ,Meng Xiangfeng
...... page:89-92
Accuracy of computer-guided implant placement and influencing factors (计算机辅助设计种植导板精确性及其影响因素)
Li Jinmeng, ,Ou Guomin
...... page:93-98
international journal of oral science zai ci huo xuan zhong guo ke ji qi kan guo ji ying xiang li ti sheng ji hua (International Journal of Oral Science再次获选中国科技期刊国际影响力提升计划)
INTERNATIONAL Journaloforalsciencebianjibu
...... page:98-98
Research progression of the relationship between integrin α2β1 and drug-induced gingival overgrowth (整合素α2β1与药物性牙龈增生相关性的研究进展)
Kang Yingzhu, ,Guo Shujuan, ,Liu Chengcheng, ,Ding Yi
...... page:99-103
bone research huo xuan zhong guo ke ji qi kan guo ji ying xiang li ti sheng ji hua (Bone Research获选中国科技期刊国际影响力提升计划)
BONE Researchbianjibu
...... page:103-103
Research progress on a nanodrug delivery system for prevention and control of dental caries and periodontal diseases (纳米载药系统防治龋病和牙周病的研究进展)
Jiang Yaling, ,Feng Mingye, ,Cheng Lei
...... page:104-107
Dental implantation in a patient with Sj?gren's syndrome:a case report (干燥综合征患者牙种植1例)
Luo Cuifen, ,Peng Guoguang, ,Feng Yuanhua, ,Huang Xingxiang
...... page:108-111
fa guo ai long ji tuan chao sheng gu dao piezotome solo quan xin shang shi (法国艾龙集团超声骨刀Piezotome Solo全新上市)
FA Guoailongjituan
...... page:111-111
hua xi kou qiang yi xue za zhi gao yue (《华西口腔医学杂志》稿约)

...... page:112-112


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Scholar : Stomatology, Year 2017, Issue 01 -New Issue Alert.



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Dear Valued Customer,

We are pleased to deliver your requested table of contents alert for Stomatology. Year 2017 Issue 01 is now available on CAOD.


In this issue:

Clinical application and related issues of self-ligating brackets (自锁托槽的临床应用及相关问题)
ZHAO Zhihe
...... page:1-4,23
Three dimensional printing SPIONs hydrogel scaffolds for tissue engineering (三维打印超顺磁性氧化铁纳米组织工程支架)
ZHOU Yi, ,HU Shuying, ,CHEN Hanbang, ,QIN Tianmu, ,XIA Yang, ,ZHANG Feimin
...... page:5-9
fang pian gao shi (防骗告示)

...... page:9-9
Effect of molar-missing on hippocampus nerve cell apoptosis and Caspase-3 protein expression in young rats (磨牙缺失对幼年大鼠海马神经元凋亡及Caspase-3蛋白表达的影响)
YU Lu, ,LI Boqi, ,LI Yu, ,ZHENG Lizhu, ,LIU Yishan
...... page:10-14
Preliminary research on improving the extraction efficiency of rats by minimally invasive method (微创方法提高大鼠拔牙效率的初步研究)
CHEN Yuanli, ,XU Guangjie, ,GUO Yuxuan, ,XIAO Weiwei, ,YANG Xia, ,HOU Rui, ,TIAN Lei
...... page:15-18
Research in the expression of LIM mineralization protein 1 during the mineralization process of two kinds of stem cells in vitro (研究两种干细胞体外矿化过程中LIM矿化蛋白1的表达)
FEI Teng, ,SUN Yanyan, ,ZHOU Yan, ,YUAN Mengtong, ,LIU Mingyue, ,SHI Xin, ,HU Weiping
...... page:19-23
Inhibitory effect of tea polyphenols on H2 O2 induced human periodontal ligament cell injury (茶多酚抑制过氧化氢诱导的牙周膜细胞损伤)
LIU Caihong, ,HU Haiyan
...... page:24-27,48
Effect of different conditions of sandblasting on surface loss of dental zirconia (不同条件的表面喷砂对牙科氧化锆材料表面丧失的影响)
LI Xin, ,SU Naichuan, ,LIAO Yunmao, ,LIU Wenjia, ,WANG Hang
...... page:28-32
Clinical evaluation of the effect of chair-side heating bleaching on healthy teeth with different positions (诊室加热恒温漂白对不同牙位自然牙漂白效果的临床评价)
XIE Haifeng, ,ZHOU Junjie, ,XI Xiaojing, ,LI Yuan, ,ZHANG Feimin, ,CHEN Chen
...... page:33-36
Curative effects and security of tacrolimus on oral lichen planus:A systematic review (他克莫司对口腔扁平苔藓疗效和安全性的系统评价)
LI Sha, ,SUN Yuliang, ,NIU Yinghui, ,ZHAO Jin
...... page:37-44
Clinical effect evaluation of the pressure spray airfloss for plaque control of patients with periodontal diseases (压力喷雾式冲牙器对牙周病患者菌斑控制的临床效果评价)
XIE Le, ,WU Juan, ,SUN Weibin
...... page:45-48
Effect observation of CAD/CAM custom abutment improving food impaction of implant restoration in posterior region (CAD/CAM个性化基台改善后牙区种植修复食物嵌塞的效果观察)
LIN Shichen, ,ZHANG Yifei, ,WU Yinyin, ,DUAN Shaoyu, ,SONG Wanhong
...... page:49-52
Impact of basic periodontal therapy on the peripheral blood IL-10 and TGF-βlevels in oral lichen planus patients (牙周基础治疗对口腔扁平苔藓患者血清中白细胞介素10及转化生长因子β的影响)
ZHANG Ruimin, ,ZHAN Yuanbo, ,ZHANG Hongchi, ,YAN Ying
...... page:53-56
kou qiang yi xue za zhi kai tong guan fang gong gong wei xin fu wu hao (《口腔医学》杂志开通官方公共微信服务号)

...... page:56-56
Comparative study of minimally invasive and traditional techniques in extraction of complex tooth (微创技术和传统技术在复杂牙拔除术中的应用及比较)
ZHAO Jun, ,LIU Na, ,HAO Xinhe, ,YE Hu
...... page:57-60
kou qiang yi xue 2017 nian za zhi zheng gao ji zheng ding qi shi (《口腔医学》2017年杂志征稿及征订启事)

...... page:60-60
Study on clinical effect of berberine gel on the treatment of minor recurrent aphthous ulcer (黄连素凝胶治疗轻型复发性阿弗他溃疡的临床疗效研究)
MA Sihuan, ,SHI Xinlian, ,LIN Jian, ,DENG Hui
...... page:61-64
can kao wen xian de shu xie ge shi (参考文献的书写格式)

...... page:64-64
Analysis of prognosis and influencing factors of mucoepidermoid carcinoma of salivary gland (唾液腺黏液表皮样癌的预后及影响因素分析)
LUO Jia, ,YANG Yan, ,YANG Sen
...... page:65-68
Clinical discussion of cracked teeth preserving (牙隐裂保存治疗临床探讨)
SUN Shuwen, ,BAI Lian
...... page:69-71
CBCT analysis of the temporomandibular joint in skeletal Class Ⅲ with high-angle in mixed dentition (替牙期骨性Ⅲ类高角错牙合颞下颌关节CBCT测量分析)
WU Qizhen, ,YANG Zhihui, ,CHEN Yonghui
...... page:72-74
Morphological changes of the condyle in adult patients with open bite by CBCT observation (成人开牙合患者髁突形态的CBCT观察研究)
WU Yanyan, ,YU Xuan, ,WANG Weifen, ,YE Zhimeng
...... page:75-77
Investigation and analysis of malocclusion in mixed dentition of 4 500 students in primary school of Shanghai (上海市4500名小学生替牙期错牙合畸形调查分析)
GUO Jiangli, ,FENG Jinqiu, ,CHEN Li
...... page:78-80
Antibacterial mechanism and influencing factors of photocatalytic nano-titanium dioxide materials (光催化纳米二氧化钛材料的抗菌机制及其影响因素)
JIA Lu, ,GAO Xu, ,GE Shaohua
...... page:81-84
Research progress on the application of nano-sized dioxide titanium in biomedicine field (纳米二氧化钛在生物医学中的应用进展)
LI Zhi, ,GE Shaohua
...... page:85-88
Influence factors of osteoclast activity in orthodontic tooth movement (正畸牙齿移动中破骨细胞活动的影响因素)
MI Yanling, ,LIU Ting, ,JIANG Ziran, ,ZHANG Fan
...... page:89-92,96
Application of Er,Cr:YSGG laser in root canal cleaning of root canal therapy (Er,Cr:YSGG激光在根管治疗术中根管清理方面的应用)
ZHOU Juan, ,TAN Yaqin, ,YE Shuang
...... page:93-96


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Scholar : chinese Journal of Practical Stomatology, Year 2017, Issue 01 -New Issue Alert.



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We are pleased to deliver your requested table of contents alert for chinese Journal of Practical Stomatology. Year 2017 Issue 01 is now available on CAOD.


In this issue:

Aesthetic characteristics of the smile aesthetic-related soft tissues (微笑美学相关软组织的美观特征)
CUI Di, ,LI Ling-jun, ,ZHOU Jing, ,LI Li-li, ,LI Hou-xuan, ,YAN Fu-hua
...... page:1-5
An overview of tooth aesthetics in smile aesthetics (微笑美学中的牙体美学概述)
CAO Yang, ,YAN Fu-hua, ,HU Qin-gang, ,LI Hou-xuan, ,YU Nian, ,YU Qing
...... page:6-9
Common problems affecting the gingival aesthetics and their treatment principles (牙龈美学常见问题及其处理原则)
LI Li-li, ,YAN Fu-hua, ,HU Qin-gang, ,YU Qing, ,CUI Di, ,LI Hou-xuan
...... page:10-14
Common evaluation indicators and methods of dental smile aesthetics (口腔微笑美学的常用评估指标和方法)
YU Nian, ,YU Qing, ,HU Qin-gang, ,YAN Fu-hua, ,LI Hou-xuan, ,CAO Yang
...... page:15-19
Periodontal evaluation of teeth post crown lengthening surgery combined with crown restorations (上前牙牙冠延长术结合冠修复后牙周健康状况分析)
WANG Cui, ,HU Wen-jie, ,ZHANG Hao
...... page:20-25
Effect comparison of all-ceramic crowns and onlays in restoring endodontically treated mandibular molar with mesio-occlusal defect (全瓷冠与高嵌体用于修复邻(牙合)面缺损根管治疗后下颌磨牙抗折强度对比研究)
ZHOU Jin-ru, ,CHEN Xi-wen, ,ZHU Zhi-min
...... page:26-30
Assessment of the 10-year cumulative survival rates and the effect of patient-related factors on the success rate of implant-supported prosthesis in the posterior maxilla (上颌后牙区不同术式种植修复10年累计存留率及患者相关因素对其成功率的影响分析)
ZHANG Yanzuo, ,LI Yue, ,HE Jing, ,JIANG Zuozuo, ,DENG Chunfu, ,ZHANG Li, ,SHANG Dehao, ,WANG Danning, ,ZHAO Baohong
...... page:31-35
Comparative study on resonance frequency analysis of implants placed in posterior maxilla using different techniques (不同方式植入上颌后牙区种植体的共振频率分析比较)
MA Lan, ,QU Zhe, ,ZHANG Xiang
...... page:36-39
Influence of glycogen synthase kinase-3β on osteogenesis of jaw bone marrow mesenchymal stem cells in inflammatory microenvironment (炎性微环境中糖原合成酶激酶-3β对颌骨来源骨髓间充质干细胞成骨分化影响研究)
HU Xiang-xiang, ,HU Kai-jin, ,ZHAO Yi-min
...... page:40-43
Effects of human stem cells from apical papilla on the proliferation of T lymphocytes (人根尖牙乳头干细胞对T淋巴细胞增殖能力影响研究)
LIU Xue-mei, ,LIU Yao, ,JIANG Li-ming, ,DING Zhen-jiang, ,CHEN Xu
...... page:44-47,52
Role of miRNAs in periodontitis and its research progress (微小RNAs在牙周致病过程中的调控机制研究进展)
JIANG Mu-zhou, ,HUANG Wan-yi, ,LIN Li
...... page:48-52
Research advances in the effect of intracanal medicaments on dental stem cells (根管消毒材料对牙源性干细胞的作用研究进展)
BI Jing, ,CHEN Xu
...... page:53-56
Lasers in prosthodontics (激光在口腔修复中的应用)
ZHANG Xin-yuan, ,KONG Ya-qun, ,WU Xiao-min, ,ZHAO Ji-zhi
...... page:57-60,64
zi ti gu ban lian he fu xue xiao ban xian wei dan bai xiu fu mei xue qu ji ke zhong zhi chun ce gu que sun 1 li bao gao (自体骨板联合富血小板纤维蛋白修复美学区即刻种植唇侧骨缺损1例报告)
ZHENG Bin, ,XU Pu, ,CHEN Ling, ,LU Liying, ,YU Dou
...... page:61-64
zhong guo shi yong kou qiang ke za zhi gao yue (《中国实用口腔科杂志》稿约)

...... page:前插1


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Scholar : Chinese Journal of Ophthalmology and otorhinolaryngology, Year 2017, Issue 01 -New Issue Alert.



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Dear Valued Customer,

We are pleased to deliver your requested table of contents alert for Chinese Journal of Ophthalmology and otorhinolaryngology. Year 2017 Issue 01 is now available on CAOD.


In this issue:

er bi hou ke yu qi jiao cha xue ke (耳鼻喉科与其交叉学科)
WANG Zhengmin
...... page:1-2
Hyperbaric oxygen therapy of sudden hearing loss (突发性聋的高压氧治疗)
CHI Fang-lu, ,ZHAO Hui
...... page:3-6
xin xi dong tai (信息动态)

...... page:6,18,32
Ocular toxocariasis in adults and recent advance in its diagnosis and management (成人眼犬弓蛔虫病特点与眼犬弓蛔虫病的诊治进展)
JIANG Rui, ,WANG Wen-ji, ,XU Ge-zhi
...... page:7-9
Expression and significance of LC3 in the retina of early stage diabetic rats (LC3在早期糖尿病大鼠视网膜的表达和意义)
LIU Qing, ,WEI Fang, ,XU Xun
...... page:10-15
Significance of the measurement of normal Chinese adult stapes (中国成人正常实体镫骨精确测量及临床意义)
GU Yu-yan, ,REN Dong-dong, ,HAN Zhao
...... page:16-18
Effect of early hyperbaric oxygen therapy on patients with profound sudden hearing loss (全聋型突发性聋高压氧早期治疗的有效性研究)
ZHAO Hui, ,CHI Fang-lu, ,JING Jiang-hua, ,REN Tong-li
...... page:19-22
Ocular diseases as first diagnosis associated with acquired immunodeficiency syndrome and human immunodeficiency virus infection (以眼部病变为首诊症状的获得性免疫缺陷综合征及人类免疫缺陷病毒感染)
HE Tai-wen, ,LU Hong-zhou, ,YANG Ya-ling, ,ZHANG Ren-fang, ,SHEN Yin-zhong, ,LIU Li, ,JIANG Rui
...... page:23-27
Changes of choroidal thickness and ocular perfusion pressure in patients with chronic renal failure after hemodialysis (慢性肾衰竭患者血液透析前后脉络膜厚度及眼灌注压变化的研究)
CHEN Nan, ,WANG Ling, ,YU Zhi-ying, ,CUI Li, ,ZHENG Hong-ying
...... page:28-32
Clinical observation on intravitreous injection of lucentis combined with panretinal photocoagulation and Ahmed glaucoma valve implantation for treatment of neovascular glaucoma (全视网膜光凝联合Ahmed引流阀植入术及雷珠单抗玻璃体腔注射治疗新生血管性青光眼)
ZHANG Shao-wei, ,HUANG Yi, ,LI Qin, ,MAO Xiao-chun, ,WANG Xue-yan
...... page:33-35,48
Clinical effect of drug treatment for uveitic macular edema (葡萄膜炎性黄斑水肿药物治疗的临床疗效)
CHEN Li-li, ,LIU Jing-xiang, ,JIANG Yu-ying, ,RUAN Xiao-ting
...... page:36-39,60
Controlled study in pterygium surgery of anchored conjunctival rotation flap and conjunctival autograft (两种翼状胬肉切除联合结膜移植术式的临床对照研究)
JIANG Dong-hong, ,JU Li-yan, ,YE Guo-sheng, ,YE Qin, ,HONG Jia-xu
...... page:40-42
Clinical observation of septoplasty combined with radiofrequency ablation for nasal septum deviation accompanied with severe perennial allergic rhinitis patients (鼻中隔矫正联合射频消融治疗伴有鼻中隔偏曲的中重度变应性鼻炎临床观察)
CHENG Mei-hao, ,YANG Long-zhen, ,YE Huai-yu, ,HU Zhi-yong
...... page:43-45,54
Clinical characteristics and treatment of pregnancy rhinitis (妊娠期鼻炎的临床特点和治疗探讨)
TAO Jia, ,LUO Ren-zhong, ,ZHOU Li-feng
...... page:46-48
Prevalence of obstructive sleep apnea hypopnea syndrome in Chinese adults aged over 20 years in Putuo district of Shanghai (上海市普陀区20岁以上人群阻塞性睡眠呼吸暂停低通气综合征流行病学调查)
HU Qing-lei, ,DU Cui-ping, ,YANG Yang, ,BAI Su-juan
...... page:49-54
Clinical analysis of somatosensory tinnitus (体觉性耳鸣患者的临床表现)
HONG Guo-wei
...... page:55-57
Comparison of choroidal thickness in patients with severe non-proliferative diabetic retinopathy before and after panretinal photocoagulation by spectral-domain optical coherence tomography (频域相干光断层扫描观察重度非增生型糖尿病视网膜病变全视网膜光凝术后脉络膜厚度的变化)
HUANG Xiao-jing, ,WEI Rui-li, ,TAN Ye
...... page:58-60
bai nei zhang chao sheng ru hua shu zhong ye ti fan liu zong he zheng 2 li (白内障超声乳化术中液体返流综合征2例)
CHEN Xiaoxia, ,ZUO Ling, ,WANG Shiyuan, ,GU Zhenzuo
...... page:61,63
fu mo hou shi ge xi bao liu lin chuang wu zhen 1 li (腹膜后嗜铬细胞瘤临床误诊1例)
HAO Zuo, ,HE Jing, ,WANG Lilun
...... page:62-63
duo fa xing gu hai mian zhuang xue guan liu 1 li (多发性骨海绵状血管瘤1例)
LIANG Juan, ,LI Hui
...... page:64,67
Research progress on differential expression of genes in allergic rhinitis (变应性鼻炎基因芯片差异表达研究进展)
LIU Xuan, ,BAI Su-juan
...... page:65-67
Relation of p27 and head and neck squamous cell carcinomas (P27蛋白与头颈鳞状细胞癌)
HU Lin-ping, ,TENG Yao-shu, ,CHEN Man-man, ,ZENG Guo-hui, ,ZHU Jin
...... page:68-70,76
xue guan shen jing yan ke xue ji bing qian xi (血管神经眼科学疾病浅析)
TIAN Guohong, ,SHA Yan
...... page:71-76
ce lu di liang xing zhong liu shou shu [ er xian wei wai ke 2007 ban ( wu shi liu )] (侧颅底良性肿瘤手术[耳显微外科2007版(五十六)])
WANG Zhengmin
...... page:77-78


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Management of Toxic Epidermal Necrolysis with Plasmapheresis and Cyclosporine A: Our 10 Years’ Experience

imageBackground: The management of toxic epidermal necrolysis (TEN) is controversial and there is no uniform strategy. Objective: To share our 10 years' experience in treating severe TEN with a novel protocol based on the association of cyclosporine A and plasmapheresis. Methods: In this case series, we retrospectively collected and assessed the 12 cases of severe TEN treated from 2005 to 2015 at the Burn Unit of the University of Bari Policlinico hospital. Results: Average body surface area was 77; average SCORETEN was 4.3. The 12 patients had been treated with culprit drug withdrawal, systemic corticosteroids, and/or cyclosporine A with no response. The protocol was successfully administered in all 12 cases. Average time to response from protocol start was 4.9 days. Average time to remission from protocol start was 22 days; average hospital stay at our unit was 24.8 days. Four patients developed severe complications; 1 patient died. No complications linked to the protocol therapeutic measures were observed. The relatively small number of cases given the rarity of the condition is a limitation of this report. Conclusion: Our protocol based on the association of cyclosporine A and plasmapheresis is safe and efficacious in treating severe TEN.

http://ift.tt/2n00lqm

Gender differences in obstructive sleep apnoea, insomnia and restless legs syndrome in adults - what do we know? A clinical update

Research in sleep medicine over the last decades has involved a broad variety of sleep disorders in both men and women. Gender differences have been identified in sleep physiology as well as in the three most common sleep disorders: obstructive sleep apnoea (OSA), insomnia and restless legs syndrome (RLS). However, research on gender differences in sleep medicine appears limited. This clinical review aims to give an updated overview of gender differences, in relation to prevalence, clinical presentation, treatment and quality of life in OSA, insomnia and RLS.

http://ift.tt/2n5C5Q4

Corrigendum to “Dry eye disease and uveitis: A closer look at immune mechanisms in animal models of two ocular autoimmune diseases” [AUTREV 15-12 (2016) 1181–1192]

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Publication date: Available online 25 March 2017
Source:Autoimmunity Reviews
Author(s): Tanima Bose, Maria Diedrichs-Möhring, Gerhild Wildner




http://ift.tt/2nipl9D

Preprosthetic surgery, fault-lines, and scholarly leadership

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Publication date: Available online 24 March 2017
Source:The Journal of Prosthetic Dentistry
Author(s): Stephen F. Rosenstiel, George A. Zarb




http://ift.tt/2ohRWv5

Multifaceted link between metabolism and cancer

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Publication date: Available online 25 March 2017
Source:Molecular and Cellular Endocrinology
Author(s): Paula Saavedra-García, Lavender Yuen-Nam Fan, Eric W-F. Lam




http://ift.tt/2nRnsmX

Interaction of IRF9 and STAT2 synergistically up-regulates IFN and PKR transcription in Ctenopharyngodon idella

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Publication date: May 2017
Source:Molecular Immunology, Volume 85
Author(s): Zhen Wu, Liqiang Wang, Xiaowen Xu, Gang Lin, Huiling Mao, Xiaoqin Ran, Tao Zhang, Keyi Huang, Haizhou Wang, Qingli Huang, Qun Xu, Chengyu Hu
IRF9 is a key factor in the JAK-STAT pathway. Under the stimulation of type I IFN, IRF9 interacts with STAT1 and STAT2 to form the IFN-I-stimulated gene factor 3 (ISGF3) which activates the transcription of ISG. However, many studies also showed that the dimmer IRF9/STAT2 rather than the tripolymer IRF9/STAT1/STAT2 acts as the ISGF3 in cells in response to IFN signals. In the present study, the full-length cDNA sequence of IRF9 (termed CiIRF9, KT601055) and STAT2 (term CiSTAT2, KT781914) from grass carp were cloned and identified. A low level of constitutive expression of CiIRF9 was detected by RT-PCR in grass carp tissues, but it was significantly up-regulated by LPS and poly I:C stimulation. In vitro, a high-affinity interaction between CiIRF9 and the promoter of CiIFN or CiPKR was demonstrated by gel mobility shift assay. In vivo, the promoter activities of CiIFN and CiPKR were not only increased by transient transfection of CiIRF9, but also prominently increased by co-transfection of CiIRF9 and CiSTAT2. Moreover, the interaction of CiIRF9 and CiSTAT2 was further investigated by in vivo and in vitro protein interaction assays. Recombinant CiIRF9 and CiSTAT2, both tagged with FLAG (or HA), were expressed in HEK 293T cells by transient transfection experiment. Co-immunoprecipitation assays showed that CiIRF9 can interact with CiSTAT2 in vivo. Soluble GST-ST2-936 (containing the N-terminal and coiled-coil domain of CiSTAT2) was expressed and purified from E. coli. A GST pull-down assay suggested that GST-tagged ST2-936 efficiently bound to FLAG-tagged IRF9. The data indicated that interaction of IRF9 and STAT2 synergistically up-regulated the transcriptional level of IFN and ISG genes.



http://ift.tt/2ohOT6g

MCPIP1 contributes to the inflammatory response of UVB-treated keratinocytes

Publication date: Available online 25 March 2017
Source:Journal of Dermatological Science
Author(s): Beata Bugara, Piotr Konieczny, Agnieszka Wolnicka-Glubisz, Leopold Eckhart, Heinz Fischer, Lukasz Skalniak, Julia Borowczyk-Michalowska, Justyna Drukala, Jolanta Jura
BackgroundMonocyte chemoattractant protein-1-induced protein-1 (MCPIP1), also known as regnase-1, negatively regulates many cellular processes including the cellular response to inflammatory agents, differentiation, viability, and proliferation. It possesses a PilT N-terminus (PIN) domain that is directly involved in regulating the stability of transcripts and miRNAs by recognizing stem loop structures and degrading them by endonucleolytic cleavage.ObjectiveWe investigated the role of MCPIP1 in the response of human primary keratinocytes to UVB stress.MethodsKeratinocytes were treated with UVB, siRNA against MCPIP1, pharmacological inhibitors of signaling pathways, or subjected to control treatments. The mRNA and protein levels of MCPIP1 and MCPIP1-dependent changes gene expression were analyzed by quantitative (Q)-RT-PCRs and Western blots. Secretion of TNFα and IL-8 was determined by ELISA.ResultsUVB treatment of keratinocytes induced upregulation of MCPIP1 at the mRNA level after 4-8h and at the protein level after 8-16h. MCPIP1 abundance depended on NF-κB activity. Using an siRNA strategy, we found that diminished MCPIP1 resulted in an up-regulation of transcripts coding for IL-8, TNFα, COX-2, and BCL-2, as well as an enhanced release of IL-8. Moreover, decreased phosphorylation of NF-κB and p38 signaling pathways were observed in addition to a slight up-regulation of ERK1/2 directly after UVB treatment. Twenty-four hours later, decreased phosphorylation was observed only for NF-κB and p38. Furthermore, in MCPIP1-suppressed cells, the levels of pro-apoptotic Puma, the phosphorylated form of p53 and the abundance of its target p21 as well as the activity of caspase 3 decreased, while the level of cyclin D1 increased.ConclusionMCPIP1 contributes to the UVB response of keratinocytes by altering metabolic and apoptotic processes and the release of inflammatory mediators.



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Corrigendum to “p62 modulates the intrinsic signaling of UVB-induced apoptosis” [Journal of Dermatological Science 83 (2016) 226–233]

Publication date: Available online 25 March 2017
Source:Journal of Dermatological Science
Author(s): Sachiko Ito, Shintaro Kimura, Eiji Warabi, Yasuhiro Kawachi, Masanobu Yamatoji, Fumihiko Uchida, Naomi Ishibashi-Kanno, Kenji Yamagata, Shogo Hasegawa, Junichi Shoda, Katsuhiko Tabuchi, Satoshi Sakai, Hiroki Bukawa, Mitsuru Sekido, Toru Yanagawa




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Twenty years of the G protein-coupled estrogen receptor GPER: historical and personal perspectives

Publication date: Available online 25 March 2017
Source:The Journal of Steroid Biochemistry and Molecular Biology
Author(s): Matthias Barton, Edward J. Filardo, Stephen J. Lolait, Peter Thomas, Marcello Maggiolini, Eric R. Prossnitz
Estrogens play a critical role in many aspects of female physiology, particularly reproductive function, but also in pathophysiology, and are associated with protection from numerous diseases in premenopausal women. Steroids and particularly estrogen action have been known for ∼90 years, with the first evidence for a receptor for estrogen presented ∼50 years ago. The original ancestral steroid receptor, extending back into evolution more than 500 million years, was likely an estrogen receptor, whereas G protein-coupled receptors (GPCRs) trace their origins back into history more than one billion years. The classical estrogen receptors (ERα and ERβ) are ligand-activated transcription factors that confer estrogen sensitivity upon many genes. It was soon apparent that these, or novel receptors may also be responsible for the "'rapid"/"non-genomic" membrane-associated effects of estrogen. The identification of an orphan GPCR (GPR30, published in 1996) opened a new field of research with the description in 2000 that GPR30 expression is required for rapid estrogen signaling. In 2005-2006, the field was greatly stimulated by two studies that described the binding of estrogen to GPR30-expressing cell membranes, followed by the identification of a GPR30-selective agonist (that lacked binding and activity towards ERα and ERβ). Renamed GPER (G protein-coupled estrogen receptor) by IUPHAR in 2007, the total number of articles in PubMed related to this receptor recently surpassed 1000. In this article, the authors present personal perspectives on how they became involved in the discovery and/or advancement of GPER research. These areas include non-genomic effects on vascular tone, receptor cloning, molecular and cellular biology, signal transduction mechanisms and pharmacology of GPER, highlighting the roles of GPER and GPER-selective compounds in diseases such as obesity, diabetes, and cancer and the obligatory role of GPER in propagating cardiovascular aging, arterial hypertension and heart failure through the regulation of Nox expression.



http://ift.tt/2nR2uEU

Prevalence of thyroid dysfunction and its impact on cognition in older mexican adults: (SADEM study)

Abstract

Introduction

Subclinical thyroid dysfunction is a possible risk factor for cognitive impairment in old age, but results are inconsistent. Aim of the present study was to evaluate the prevalence of thyroid dysfunction among older community-dwelling adults and to see whether thyroid function impacts the cognitive status of the elderly.

Methods

We included 1750 participants from the Study on Aging and Dementia in Mexico (SADEM). All subjects were evaluated clinically via specific interviews. TSH levels were analyzed by chemiluminescent immunometry assay. We classified participants into five thyroid state groups: (1) normal TSH levels (0.40–4.0 IU/L) were considered euthyroid; (2) Overt hyperthyroidism: TSH <0.3 IU/l and FT4 >23 pmol/l; (3) Overt hypothyroidism: TSH >4.8 IU/l, FT4 <13 pmol/l; (4) Subclinical hyperthyroidism: TSH <0.3 IU/l, FT4: 13–23 pmol/l; (5) Subclinical hypothyroidism: TSH >4.8 IU/l, FT4: 13–23 pmol/l.

Results

The overall estimated prevalence of thyroid dysfunction in Mexican population was 23.7% (95% CI, 22.66–26.77). Of these, 15.4% older adults were classified as subclinical hypothyroidism, 7.2% overt hypothyroidism, 0.5% subclinical hyperthyroidism, and 0.6% overt hyperthyroidism. The association of thyroid dysfunction with cognitive impairment was most evident in overt hypothyroidism OR = 1.261 (1.185–1.343).

Conclusions

The present study demonstrated a high prevalence of thyroid dysfunction in Mexican elderly people living in the community. A relationship between cognitive impairment and the presence of hypothyroidism was also shown, and to a lesser degree in hyperthyroidism.



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Do glucocorticoids induce addiction in humans?



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Ultrasound Stimulation of Insulin Release from Pancreatic Beta Cells as a Potential Novel Treatment for Type 2 Diabetes

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Publication date: Available online 25 March 2017
Source:Ultrasound in Medicine & Biology
Author(s): Ivan Suarez Castellanos, Aleksandar Jeremic, Joshua Cohen, Vesna Zderic
Type 2 diabetes mellitus is a complex metabolic disease that has reached epidemic proportions in the United States and around the world. This disease is characterized by loss of insulin secretion and, eventually, destruction of insulin-producing pancreatic beta cells. Controlling type 2 diabetes is often difficult as pharmacological management routinely requires complex therapy with multiple medications, and loses its effectiveness over time. The objective of this study was to explore the effectiveness of a novel, non-pharmacological approach that uses the application of ultrasound energy to augment insulin release from rat INS 832/13 beta cells. The cells were exposed to unfocused ultrasound for 5 min at a peak intensity of 1 W/cm2 and frequencies of 400 kHz, 600 kHz, 800 kHz and 1 MHz. Insulin release was measured with enzyme-linked immunosorbent assay and cell viability was assessed via the trypan blue dye exclusion test. A marked release (approximately 150 ng/106 cells, p < 0.05) of insulin was observed when beta cells were exposed to ultrasound at 400 and 600 kHz as compared with their initial control values; however, this release was accompanied by a substantial loss in cell viability. Ultrasound application at frequencies of 800 kHz resulted in 24 ng/106 cells released insulin (p < 0.05) as compared with its unstimulated base level, while retaining cell viability. Insulin release from beta cells caused by application of 800-kHz ultrasound was comparable to that reported by the secretagogue glucose, thus operating within physiological secretory capacity of these cells. Ultrasound has potential as a novel and alternative method to current approaches aimed at correcting secretory deficiencies in patients with type 2 diabetes.



http://ift.tt/2nzOe2Q

Liver metastases from gastric carcinoma. Case Report and Review of the literature

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Publication date: Available online 24 March 2017
Source:Current Problems in Cancer
Author(s): Beata Polkowska-Pruszyńska, Karol Rawicz-Pruszyński, Bogumiła Ciseł, Robert Sitarz, Grażyna Polkowska, Witold Krupski, Wojciech P. Polkowski
Gastric carcinoma (GC) is the fifth most common malignancy worldwide but the third leading cause of cancer death, and surgery remains the only curative treatment option. Prognosis of patients with liver metastases from gastric carcinoma (LMGC) is poor, and the optimal treatment of metastatic gastric cancer remains a matter of debate. In 2002 a 53-year-old male patient with GC and synchronous oligometastatic lesion in liver VIII segment underwent a total gastrectomy combined with metastasectomy. The pathological diagnosis was stage IV gastric adenocarcinoma (pT3N2M1), which was treated with adjuvant chemotherapy (PELF). In 2012 abdominal ultrasound and percutaneous liver biopsy revealed recurrence of the metastasis in the right liver lobe. Progression of the disease was observed after palliative chemotherapy (EOX). Nevertheless an extended right-hemihepatectomy, with excision of segments 1, 4A, 5, 6, 7 and 8, was still performed. Pathological examination confirmed large KRAS-, and HER2-negative LMGC. The patient is alive and free of disease 47 months after the repeated hepatectomy, and 13 years after removal of the primary GC and synchronous liver metastasis. Based on review of 27 articles, 5-year OS rate following gastrectomy and liver metastasectomy may reach 60%, with median survival time up to 74 months.  Although the combination of aggressive surgical approach with systemic therapy for LMGC is controversial, it may allow favourable outcome. Careful selection of patients based on evaluable predictive factors for R0 surgical resection of both, primary tumour and liver metastases can lead to cure, as shown in our case presentation, where 10 year relapse-free survival was observed, followed by successful repeated hepatectomy due to liver metastases.



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Functional connectivity and activity of white matter in somatosensory pathways under tactile stimulations

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Publication date: 15 May 2017
Source:NeuroImage, Volume 152
Author(s): Xi Wu, Zhipeng Yang, Stephen K. Bailey, Jiliu Zhou, Laurie E. Cutting, John C. Gore, Zhaohua Ding
Functional MRI has proven to be effective in detecting neural activity in brain cortices on the basis of blood oxygenation level dependent (BOLD) contrast, but has relatively poor sensitivity for detecting neural activity in white matter. To demonstrate that BOLD signals in white matter are detectable and contain information on neural activity, we stimulated the somatosensory system and examined distributions of BOLD signals in related white matter pathways. The temporal correlation profiles and frequency contents of BOLD signals were compared between stimulation and resting conditions, and between relevant white matter fibers and background regions, as well as between left and right side stimulations. Quantitative analyses show that, overall, MR signals from white matter fiber bundles in the somatosensory system exhibited significantly greater temporal correlations with the primary sensory cortex and greater signal power during tactile stimulations than in a resting state, and were stronger than corresponding measurements for background white matter both during stimulations and in a resting state. The temporal correlation and signal power under stimulation were found to be twice those observed from the same bundle in a resting state, and bore clear relations with the side of stimuli. These indicate that BOLD signals in white matter fibers encode neural activity related to their functional roles connecting cortical volumes, which are detectable with appropriate methods.



http://ift.tt/2n4Sc08

Single or multiple frequency generators in on-going brain activity: A mechanistic whole-brain model of empirical MEG data

Publication date: 15 May 2017
Source:NeuroImage, Volume 152
Author(s): Gustavo Deco, Joana Cabral, Mark W. Woolrich, Angus B.A. Stevner, Tim J. van Hartevelt, Morten L. Kringelbach
During rest, envelopes of band-limited on-going MEG signals co-vary across the brain in consistent patterns, which have been related to resting-state networks measured with fMRI. To investigate the genesis of such envelope correlations, we consider a whole-brain network model assuming two distinct fundamental scenarios: one where each brain area generates oscillations in a single frequency, and a novel one where each brain area can generate oscillations in multiple frequency bands. The models share, as a common generator of damped oscillations, the normal form of a supercritical Hopf bifurcation operating at the critical border between the steady state and the oscillatory regime. The envelopes of the simulated signals are compared with empirical MEG data using new methods to analyse the envelope dynamics in terms of their phase coherence and stability across the spectrum of carrier frequencies.Considering the whole-brain model with a single frequency generator in each brain area, we obtain the best fit with the empirical MEG data when the fundamental frequency is tuned at 12Hz. However, when multiple frequency generators are placed at each local brain area, we obtain an improved fit of the spatio-temporal structure of on-going MEG data across all frequency bands. Our results indicate that the brain is likely to operate on multiple frequency channels during rest, introducing a novel dimension for future models of large-scale brain activity.

Graphical abstract

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Joint prediction of longitudinal development of cortical surfaces and white matter fibers from neonatal MRI

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Publication date: 15 May 2017
Source:NeuroImage, Volume 152
Author(s): Islem Rekik, Gang Li, Pew-Thian Yap, Geng Chen, Weili Lin, Dinggang Shen
The human brain can be modeled as multiple interrelated shapes (or a multishape), each for characterizing one aspect of the brain, such as the cortex and white matter pathways. Predicting the developing multishape is a very challenging task due to the contrasting nature of the developmental trajectories of the constituent shapes: smooth for the cortical surface and non-smooth for white matter tracts due to changes such as bifurcation. We recently addressed this problem and proposed an approach for predicting the multishape developmental spatiotemporal trajectories of infant brains based only on neonatal MRI data using a set of geometric, dynamic, and fiber-to-surface connectivity features. In this paper, we propose two key innovations to further improve the prediction of multishape evolution. First, for a more accurate cortical surface prediction, instead of simply relying on one neonatal atlas to guide the prediction of the multishape, we propose to use multiple neonatal atlases to build a spatially heterogeneous atlas using the multidirectional varifold representation. This individualizes the atlas by locally maximizing its similarity to the testing baseline cortical shape for each cortical region, thereby better representing the baseline testing cortical surface, which founds the multishape prediction process. Second, for temporally consistent fiber prediction, we propose to reliably estimate spatiotemporal connectivity features using low-rank tensor completion, thereby capturing the variability and richness of the temporal development of fibers. Experimental results confirm that the proposed variants significantly improve the prediction performance of our original multishape prediction framework for both cortical surfaces and fiber tracts shape at 3, 6, and 9 months of age. Our pioneering model will pave the way for learning how to predict the evolution of anatomical shapes with abnormal changes. Ultimately, devising accurate shape evolution prediction models that can help quantify and predict the severity of a brain disorder as it progresses will be of great aid in individualized treatment planning.



http://ift.tt/2mCiieO

Reduction of across-run variability of temporal SNR in accelerated EPI time-series data through FLEET-based robust autocalibration

Publication date: 15 May 2017
Source:NeuroImage, Volume 152
Author(s): Anna I. Blazejewska, Himanshu Bhat, Lawrence L. Wald, Jonathan R. Polimeni
Temporal signal-to-noise ratio (tSNR) is a key metric for assessing the ability to detect brain activation in fMRI data. A recent study has shown substantial variation of tSNR between multiple runs of accelerated EPI acquisitions reconstructed with the GRAPPA method using protocols commonly used for fMRI experiments. Across-run changes in the location of high-tSNR regions could lead to misinterpretation of the observed brain activation patterns, reduced sensitivity of the fMRI studies, and biased results. We compared conventional EPI autocalibration (ACS) methods with the recently-introduced FLEET ACS method, measuring their tSNR variability, as well as spatial overlap and displacement of high-tSNR clusters across runs in datasets acquired from human subjects at 7T and 3T. FLEET ACS reconstructed data had higher tSNR levels, as previously reported, as well as better temporal consistency and larger overlap of the high-tSNR clusters across runs compared with reconstructions using conventional multi-shot (ms) EPI ACS data. tSNR variability across two different runs of the same protocol using ms-EPI ACS data was about two times larger than for the protocol using FLEET ACS for acceleration factors (R) 2 and 3, and one and half times larger for R=4. The level of across-run tSNR consistency for data reconstructed with FLEET ACS was similar to within-run tSNR consistency. The displacement of high-tSNR clusters across two runs (inter-cluster distance) decreased from ∼8mm in the time-series reconstructed using conventional ms-EPI ACS data to ∼4mm for images reconstructed using FLEET ACS. However, the performance gap between conventional ms-EPI ACS and FLEET ACS narrowed with increasing parallel imaging acceleration factor. Overall, the FLEET ACS method provides a simple solution to the problem of varying tSNR across runs, and therefore helps ensure that an assumption of fMRI analysis—that tSNR is largely consistent across runs—is met for accelerated acquisitions.

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Human centromedian-parafascicular complex signals sensory cues for goal-oriented behavior selection

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Publication date: 15 May 2017
Source:NeuroImage, Volume 152
Author(s): Inga M. Schepers, Anne-Kathrin Beck, Susann Bräuer, Kerstin Schwabe, Mahmoud Abdallat, Pascale Sandmann, Reinhard Dengler, Jochem W. Rieger, Joachim K. Krauss
Experimental research has shown that the centromedian-parafascicular complex (CM-Pf) of the intralaminar thalamus is activated in attentional orienting and processing of behaviorally relevant stimuli. These observations resulted in the hypothesis that the CM-Pf plays a pivotal role in goal-oriented behavior selection. We here set out to test this hypothesis with electrophysiological recordings from patients with electrodes implanted in CM-Pf for deep brain stimulation (DBS) treatment of chronic neuropathic pain. Six patients participated in (1) an auditory three-class oddball experiment, which required a button press to target tones, but not to standard and deviant tones and in (2) a multi-speaker experiment with a target word that required attention selection and a target image that required response selection. Subjects showed transient neural responses (8–15Hz) to the target tone and the target word. Two subjects additionally showed transient neural responses (15–25Hz) to the target image. All sensory target stimuli were related to an internal goal and required a behavior selection (attention selection, response selection). In group analyses, neural responses were greater to target tones than deviant and standard tones and to target words than other task-relevant words that did not require attention selection. The transient neural responses occurred after the target stimuli but prior to the overt behavioral response. Our results demonstrate that in human subjects the CM-Pf is involved in signaling sensory inputs related to goal-oriented selection of behavior.



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Proportional thresholding in resting-state fMRI functional connectivity networks and consequences for patient-control connectome studies: Issues and recommendations

Publication date: 15 May 2017
Source:NeuroImage, Volume 152
Author(s): Martijn P. van den Heuvel, Siemon C. de Lange, Andrew Zalesky, Caio Seguin, B.T. Thomas Yeo, Ruben Schmidt
Graph theoretical analysis has become an important tool in the examination of brain dysconnectivity in neurological and psychiatric brain disorders. A common analysis step in the construction of the functional graph or network involves "thresholding" of the connectivity matrix, selecting the set of edges that together form the graph on which network organization is evaluated. To avoid systematic differences in absolute number of edges, studies have argued against the use of an "absolute threshold" in case-control studies and have proposed the use of "proportional thresholding" instead, in which a pre-defined number of strongest connections are selected as network edges, ensuring equal network density across datasets. Here, we systematically studied the effect of proportional thresholding on the construction of functional matrices and subsequent graph analysis in patient-control functional connectome studies. In a few simple experiments we show that differences in overall strength of functional connectivity (FC) – as often observed between patients and controls – can have predictable consequences for between-group differences in network organization. In individual networks with lower overall FC the proportional thresholding algorithm has to select more edges based on lower correlations, which have (on average) a higher probability of being spurious, and thus introduces a higher degree of randomness in the resulting network. We show across both empirical and artificial patient-control datasets that lower levels of overall FC in either the patient or control group will most often lead to differences in network efficiency and clustering, suggesting that differences in FC across subjects will be artificially inflated or translated into differences in network organization. Based on the presented case-control findings we inform about the caveats of proportional thresholding in patient-control studies in which groups show a between-group difference in overall FC. We make recommendations on how to examine, report and to take into account overall FC effects in future patient-control functional connectome studies.



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The IVIM signal in the healthy cerebral gray matter: A play of spherical and non-spherical components

Publication date: 15 May 2017
Source:NeuroImage, Volume 152
Author(s): Tim Finkenstaedt, Markus Klarhoefer, Christian Eberhardt, Anton S. Becker, Gustav Andreisek, Andreas Boss, Cristina Rossi
The intra-voxel incoherent motion (IVIM) model assumes that blood flowing in isotropically distributed capillary segments induces a phase dispersion of the MR signal, which increases the signal attenuation in diffusion-weighted images. However, in most tissue types the capillary network has an anisotropic micro-architecture. In this study, we investigated the possibility to indirectly infer the anisotropy of the capillary network in the healthy cerebral gray matter by evaluating the dependence of the IVIM signal from the direction of the diffusion-encoding.Perfusion-related indices and self-diffusion were modelled as symmetric rank 2 tensors. The geometry of the tensors was quantified pixel-wise by decomposing the tensor in sphere-like, plane-like, and line-like components. Additionally, trace and fractional anisotropy of the tensors were computed.While the self-diffusion tensor is dominated by a spherical geometry with a residual contribution of the non-spherical components, both, fraction of perfusion and pseudo-diffusion, present a substantial (in the order of 30%) contribution of planar and linear components to the tensor metrics.This study shows that the IVIM perfusion estimates in the cerebral gray matter present a detectable deviation from the spherical model. These non-spherical components may reflect the direction-dependent morphology of the microcirculation. Therefore, the tensor generalization of the IVIM model may provide a tool for the non-invasive monitoring of cerebral capillary micro-architecture during development, aging or in pathologies.

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Comparing GABA-dependent physiological measures of inhibition with proton magnetic resonance spectroscopy measurement of GABA using ultra-high-field MRI

Publication date: 15 May 2017
Source:NeuroImage, Volume 152
Author(s): Katherine Dyke, Sophia E. Pépés, Chen Chen, Soyoung Kim, Hilmar P. Sigurdsson, Amelia Draper, Masud Husain, Parashkev Nachev, Penelope A. Gowland, Peter G. Morris, Stephen R. Jackson
Imbalances in glutamatergic (excitatory) and GABA (inhibitory) signalling within key brain networks are thought to underlie many brain and mental health disorders, and for this reason there is considerable interest in investigating how individual variability in localised concentrations of these molecules relate to brain disorders. Magnetic resonance spectroscopy (MRS) provides a reliable means of measuring, in vivo, concentrations of neurometabolites such as GABA, glutamate and glutamine that can be correlated with brain function and dysfunction. However, an issue of much debate is whether the GABA observed and measured using MRS represents the entire pool of GABA available for measurement (i.e., metabolic, intracellular, and extracellular) or is instead limited to only some portion of it. GABA function can also be investigated indirectly in humans through the use of non-invasive transcranial magnetic stimulation (TMS) techniques that can be used to measure cortical excitability and GABA-mediated physiological inhibition. To investigate this issue further we collected in a single session both types of measurement, i.e., TMS measures of cortical excitability and physiological inhibition and ultra-high-field (7 T) MRS measures of GABA, glutamate and glutamine, from the left sensorimotor cortex of the same group of right-handed individuals. We found that TMS and MRS measures were largely uncorrelated with one another, save for the plateau of the TMS IO curve that was negatively correlated with MRS-Glutamate (Glu) and intra-cortical facilitation (10ms ISI) that was positively associated with MRS-Glutamate concentration. These findings are consistent with the view that the GABA concentrations measured using the MRS largely represent pools of GABA that are linked to tonic rather than phasic inhibition and thus contribute to the inhibitory tone of a brain area rather than GABAergic synaptic transmission.



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Interactions between the anterior cingulate-insula network and the fronto-parietal network during perceptual decision-making

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Publication date: 15 May 2017
Source:NeuroImage, Volume 152
Author(s): Ganesh B. Chand, Mukesh Dhamala
Information processing in the human brain during cognitively demanding goal-directed tasks is thought to involve several large-scale brain networks, including the anterior cingulate-insula network (aCIN) and the fronto-parietal network (FPN). Recent functional MRI (fMRI) studies have provided clues that the aCIN initiates activity changes in the FPN. However, when and how often these networks interact remains largely unknown to date. Here, we systematically examined the oscillatory interactions between the aCIN and the FPN by using the spectral Granger causality analysis of reconstructed brain source signals from the scalp electroencephalography (EEG) recorded from human participants performing a face-house perceptual categorization task. We investigated how the aCIN and the FPN interact, what the temporal sequence of events in these nodes is, and what frequency bands of information flow bind these nodes in networks. We found that beta band (13–30Hz) and gamma (30–100Hz) bands of interactions are involved between the aCIN and the FPN during decision-making tasks. In gamma band, the aCIN initiated the Granger causal control over the FPN in 25–225 ms timeframe. In beta band, the FPN achieved a control over the aCIN in 225–425 ms timeframe. These band-specific time-dependent Granger causal controls of the aCIN and the FPN were retained for behaviorally harder decision-making tasks. These findings of times and frequencies of oscillatory interactions in the aCIN and FPN provide us new insights into the general neural mechanisms for sensory information-guided, goal-directed behaviors, including perceptual decision-making processes.



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Knowing what from where: Hippocampal connectivity with temporoparietal cortex at rest is linked to individual differences in semantic and topographic memory

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Publication date: 15 May 2017
Source:NeuroImage, Volume 152
Author(s): Mladen Sormaz, Elizabeth Jefferies, Boris C. Bernhardt, Theodoros Karapanagiotidis, Giovanna Mollo, Neda Bernasconi, Andrea Bernasconi, Tom Hartley, Jonathan Smallwood
The hippocampus contributes to episodic, spatial and semantic aspects of memory, yet individual differences within and between these functions are not well-understood. In 136 healthy individuals, we investigated whether these differences reflect variation in the strength of connections between functionally-specialised segments of the hippocampus and diverse cortical regions that participate in different aspects of memory. Better topographical memory was associated with stronger connectivity between lingual gyrus and left anterior, rather than posterior, hippocampus. Better semantic memory was associated with increased connectivity between the intracalcarine/cuneus and left, rather than right, posterior hippocampus. Notably, we observed a double dissociation between semantic and topographical memory: better semantic memory was associated with stronger connectivity between left temporoparietal cortex and left anterior hippocampus, while better topographic memory was linked to stronger connectivity with right anterior hippocampus. Together these data support a division-of-labour account of hippocampal functioning: at the population level, differences in connectivity across the hippocampus reflect functional specialisation for different facets of memory, while variation in these connectivity patterns across individuals is associated with differences in the capacity to retrieve different types of information. In particular, within-hemisphere connectivity between hippocampus and left temporoparietal cortex supports conceptual processing at the expense of spatial ability.



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Teams on the same wavelength perform better: Inter-brain phase synchronization constitutes a neural substrate for social facilitation

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Publication date: 15 May 2017
Source:NeuroImage, Volume 152
Author(s): Caroline Szymanski, Ana Pesquita, Allison A. Brennan, Dionysios Perdikis, James T. Enns, Timothy R. Brick, Viktor Müller, Ulman Lindenberger
Working together feels easier with some people than with others. We asked participants to perform a visual search task either alone or with a partner while simultaneously measuring each participant's EEG. Local phase synchronization and inter-brain phase synchronization were generally higher when subjects jointly attended to a visual search task than when they attended to the same task individually. Some participants searched the visual display more efficiently and made faster decisions when working as a team, whereas other dyads did not benefit from working together. These inter-team differences in behavioral performance gain in the visual search task were reliably associated with inter-team differences in local and inter-brain phase synchronization. Our results suggest that phase synchronization constitutes a neural correlate of social facilitation, and may help to explain why some teams perform better than others.



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Prospective Trial of House Staff Time to Response and Intervention in a Surgical Intensive Care Unit: Pager vs. Smartphone

Publication date: Available online 24 March 2017
Source:Journal of Surgical Education
Author(s): James M. Tatum, Terris White, Christopher Kang, Eric J. Ley, Nicolas Melo, Matthew Bloom, Rodrigo F. Alban
ObjectiveThe objective of the study was to characterize house staff time to response and intervention when notified of a patient care issue by pager vs. smartphone. We hypothesized that smartphones would reduce house staff time to response and intervention.DesignProspective study of all electronic communications was conducted between nurses and house staff between September 2015 and October 2015. The 4-week study period was randomly divided into two 2-week study periods where all electronic communications between intensive care unit nurses and intensive care unit house staff were exclusively by smartphone or by pager, respectively. Time of communication initiation, time of house staff response, and time from response to clinical intervention for each communication were recorded. Outcomes are time from nurse contact to house staff response and intervention.SettingSingle-center surgical intensive care unit of Cedars-Sinai Medical Center in Los Angeles, California, an academic tertiary care and level I trauma center.ParticipantsAll electronic communications occurring between nurses and house staff in the study unit during the study period were considered. During the study period, 205 nurse-house staff electronic communications occurred, 100 in the phone group and 105 in the pager group.ResultsHouse staff response to communication time was significantly shorter in the phone group (0.5 [interquartile range = 1.7] vs. 2 [3]min, p < 0.001). Time to house staff intervention after response was also significantly more rapid in the phone group (0.8 [1.7] vs. 1 [2]min, p = 0.003).ConclusionsDedicated clinical smartphones significantly decrease time to house staff response after electronic nursing communications compared with pagers.



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An Assessment of the Frequency of Palliative Procedures in Thoracic Surgery

Publication date: Available online 24 March 2017
Source:Journal of Surgical Education
Author(s): Richard K. Freeman, Gabriel Arevalo, Anthony J. Ascioti, Megan Dake, Raja S. Mahidhara
ObjectivesPalliative care is a medical specialty focused on improving the quality of life of patients and their families with life threatening illness by preventing or relieving suffering. An assessment of a thoracic surgery service was performed to identify the scope and frequency of care that was considered palliative and any implications the findings might have on the current thoracic surgery residency curriculum.MethodsA retrospective review of a prospectively collected database of general thoracic surgery procedures performed over a 5-year period at a single institution was performed. Procedures considered palliative were reviewed for demographics, diagnoses, palliative prognosis score, treatment, morbidity, operative mortality, and survival. Excluded were referrals from thoracic surgery to other specialties for palliative procedures.ResultsDuring the study period, 3842 procedures were performed of which 884 (23%) were palliative. Indications included pleural or pericardial effusion or both, dysphagia, hemoptysis, tracheobronchial obstruction, bronchopleural fistula, and tracheoesophageal fistula. The majority was related to a malignancy. Only 127 patients (14%) had a palliative care assessment before thoracic surgery consultation. Mean survival following thoracic surgery intervention was 110 days for patients with malignancy.ConclusionsThis investigation found that thoracic surgeons commonly care for patients when the intention or indication or both is palliation. Most of these patients have an associated malignancy, a poor performance status and a projected significantly decreased survival compared with the general population. Thoracic surgeons should be familiar with the concepts of palliative care and consideration should be given to expanding exposure to the principles of palliative care in the cardiothoracic residency training curriculum.



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Application of benchtop and portable near-infrared spectrometers for predicting the optimum harvest time of Verbena officinalis

Publication date: 1 July 2017
Source:Talanta, Volume 169
Author(s): Cornelia K. Pezzei, Stefan A. Schönbichler, Christian G. Kirchler, Julia Schmelzer, Shah Hussain, Verena A. Huck-Pezzei, Michael Popp, Justine Krolitzek, Günther K. Bonn, Christian W. Huck
This study examined the applicability of near-infrared (NIR) spectroscopy coupled with multivariate data analysis (MVA) to determine the ideal harvest time of Verbena officinalis. NIR analyses were performed non-invasively on the fresh plant material based on the quantification of the key constituents verbenalin and verbascoside. Vibrational spectroscopic measurements were performed applying a conventional NIR benchtop device as well as a laboratory independent handheld NIR spectrometer. A novel high performance liquid chromatography (HPLC) method was applied as a reference method. For both instruments partial least squares (PLS) regression models were established performing cross validations (CV) and test-set validations (TSV). Quality parameters obtained for the benchtop device revealed that the newly established NIR method enabled reliable quantifications of the main compounds verbenalin and verbascoside related to the dried and fresh plant material. The results of the miniaturised spectrometer revealed that accurate quantitative calibration models could be developed for verbascoside achieving a comparable prediction power to the benchtop device. PLS models for verbenalin were less precise suggesting the application of portable devices including a different spectral range and resolution. The work demonstrated the feasibility of NIR vibrational spectroscopy performing direct measurements on pharmaceutically relevant fresh plant material enabling a quick and simple determination of the ideal harvest time of Verbena officinalis.

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