Age and Periodontal Health—Immunological View

Abstract

Purpose of the Review

Aging clearly impacts a wide array of systems, in particular the breadth of the immune system leading to immunosenescence, altered immunoactivation, and coincident inflammaging processes. The net result of these changes leads to increased susceptibility to infections, increased neoplastic occurrences, and elevated frequency of autoimmune diseases with aging. However, as the bacteria in the oral microbiome that contribute to the chronic infection of periodontitis is acquired earlier in life, the characteristics of the innate and adaptive immune systems to regulate these members of the autochthonous microbiota across the lifespan remains ill-defined.

Recent Findings

Clear data demonstrate that both cells and molecules of the innate and adaptive immune response are adversely impacted by aging, including in the oral cavity, yielding a reasonable tenet that the increased periodontitis noted in aging populations is reflective of the age-associated immune dysregulation. Additionally, this facet of host-microbe interactions and disease needs to accommodate the population variation in disease onset and progression, which may also reflect an accumulation of environmental stressors and/or decreased protective nutrients that could function at the gene level (i.e., epigenetic) or translational level for production and secretion of immune system molecules.

Summary

Finally, the majority of studies of aging and periodontitis have emphasized the increased prevalence/severity of disease with aging, all based upon chronological age. However, evolving areas of study focusing on "biological aging" to help account for population variation in disease expression may suggest that chronic periodontitis represents a co-morbidity that contributes to "gerovulnerability" within the population.

https://ift.tt/2AQpHwJ

Modeling daily water temperature for rivers: comparison between adaptive neuro-fuzzy inference systems and artificial neural networks models

Abstract

River water temperature is a key control of many physical and bio-chemical processes in river systems, which theoretically depends on multiple factors. Here, four different machine learning models, including multilayer perceptron neural network models (MLPNN), adaptive neuro-fuzzy inference systems (ANFIS) with fuzzy c-mean clustering algorithm (ANFIS_FC), ANFIS with grid partition method (ANFIS_GP), and ANFIS with subtractive clustering method (ANFIS_SC), were implemented to simulate daily river water temperature, using air temperature (T_a), river flow discharge (Q), and the components of the Gregorian calendar (CGC) as predictors. The proposed models were tested in various river systems characterized by different hydrological conditions. Results showed that including the three inputs as predictors (T_a, Q, and the CGC) yielded the best accuracy among all the developed models. In particular, model performance improved considerably compared to the case where only T_a is used as predictor, which is the typical approach of most of previous machine learning applications. Additionally, it was found that Q played a relevant role mainly in snow-fed and regulated rivers with higher-altitude hydropower reservoirs, while it improved to a lower extent model performance in lowland rivers. In the validation phase, the MLPNN model was generally the one providing the highest performances, although in some river stations ANFIS_FC and ANFIS_GP were slightly more accurate. Overall, the results indicated that the machine learning models developed in this study can be effectively used for river water temperature simulation.

https://ift.tt/2QlNFFn

Cosmetics, Vol. 5, Pages 65: ES2 as a Novel Verbascoside-Derived Compound in the Treatment of Cutaneous Wound Healing

Cosmetics, Vol. 5, Pages 65: ES2 as a Novel Verbascoside-Derived Compound in the Treatment of Cutaneous Wound Healing

Cosmetics doi: 10.3390/cosmetics5040065

Authors: Ilaria Crivellari Silvia Vertuani Yunsook Lim Franco Cervellati Anna Baldisserotto Stefano Manfredini Giuseppe Valacchi

Several pathologies are characterized by chronic wounds and often resistant to many of the common therapies, leading to chronic infections that can become even life-threatening for patients. For this reason, the identification of new products able to ameliorate the healing process is still an on-going research. Natural compounds have been used to improve skin conditions due to their dermo-cosmetic and therapeutic activities including anti-inflammatory, antioxidant and cell-migratory properties. Among these compounds, it has been recently demonstrated that Verbascoside, a phenyl propanoid glycoside widely used in the cosmetic field, can improve keratinocytes proliferation. Because of its high hydrophilic character, Verbascoside has a limited range of possible topical applications and the synthesis of ES2, a semi-synthetic derivative of Verbascoside was performed to bypass some of the drawback aspects of this molecule. In the present study, the wound healing properties of Verbascoside and ES2 were compared in both keratinocytes “in vitro” wound scratch and in wounded SKH1 mice. The results showed that both compounds were not cytotoxic and ES2 showed an efficient ability to promote the proliferation of human keratinocytes compared to Verbascoside. The findings were also confirmed in vivo but only at early time points (2/3 days). Taken together, these data suggest that the Verbascoside-derivative ES2 could be considered a novel and promising candidate for the topical treatment of wounds.

https://ift.tt/2qvKxvg

Evaluation of the potential of sewage sludge as a valuable fertilizer for wheat ( Triticum aestivum L.) crops

Abstract

A greenhouse experiment was performed to assess the soil heavy metal pools, growth, yield, and heavy metal uptake of wheat plants (Triticum aestivum L.) that are grown at different rates in soils supplemented with sewage sludge (SS). The experimental design was completely randomized, with six replicates per treatment. The application of SS significantly increased the soil organic matter content. Generally, most growth parameters, as well as the biomass of treated wheat, were significantly increased with the amendment of SS, up to the addition rate of 40 g kg⁻¹. The content of all heavy metals (except Cr in grains and Pb in spikes) significantly increased in different tissues of treated wheat with the increasing rate of SS application. However, all heavy metal concentrations (except for Al, Cr, Fe, and Mn in the roots) were normal and did not overcome the phytotoxic levels. The wheat was recognized by a bioaccumulation factor < 1.0 for most of the heavy metals. The translocation factor for all of the heavy metals was < 1.0. Therefore, the SS utilized in the present study could be used as a valuable organic fertilizer in wheat cultivation areas in Saudi Arabia and could also act as an eco-friendly method for the recycling of SS.

https://ift.tt/2qwkdkz

IEnhanced Topical Delivery of Non-complexed Molecular Iodine for Methicillin-Resistant Staphylococcus aureus Decolonization.

Related Articles

IEnhanced Topical Delivery of Non-complexed Molecular Iodine for Methicillin-Resistant Staphylococcus aureus Decolonization.

Int J Pharm. 2018 Nov 02;:

Authors: Uchiyama S, Dahesh S, Nizet V, Kessler J

Abstract
Staphylococcus aureus, a leading cause of serious human infections in both healthcare and community settings, is increasingly difficult to control due to expanding resistance to multiple antibiotic classes. Methicillin-resistant S. aureus (MRSA) strains have disseminated on a global scale and are associated with adverse patient outcomes, increased hospital stays, and significant economic costs to the healthcare system. A proximal step in S. aureus infection is colonization of the nasal mucosa, and effective strategies to decolonize high risk patients to reduce the risk of invasive infection and nosocomial spread represent an important clinical priority. With rising resistance to mupirocin, the most common antibiotic utilized for nasal MRSA decontamination, we are examining the use of pure molecular iodine (I2)-based formulations for this indication. Recently, an iodophor formulation of povidone-iodine (PVP-I) has shown significant promise for nasal MRSA decontamination by swabbing the anterior nares of patients in hospital settings, but the I2 concentration in this treatment is less than 0.01% of total iodine species present and like all providone-iodine formulations causes skin staining. Here we determine that a novel non-staining formulation of I2 combined with the safe organic emollient glycerin, delivers high local concentrations of the active antimicrobial entity (I2) with minimal evaporative loss, exhibits activity at ∼1 part per million against MRSA and other important Gram-positive and -negative human pathogens. This formulation for I2 topical delivery produced similar reductions in mean bacterial burden and was associated with fewer treatment failures (< 2-logfold reduction) than PVP-I in a murine model of MRSA nasal decontamination. Formulations of I2 in glycerin emollient merit further exploration as topical disinfectants for human medical indications.

PMID: 30395958 [PubMed - as supplied by publisher]

https://ift.tt/2yUbi1e

Prevalence of antibiotic-resistant organisms in Canadian Hospitals. Comparison of point-prevalence survey results from 2010, 2012, and 2016.

Related Articles

Prevalence of antibiotic-resistant organisms in Canadian Hospitals. Comparison of point-prevalence survey results from 2010, 2012, and 2016.

Infect Control Hosp Epidemiol. 2018 Nov 05;:1-7

Authors: Martin P, Abou Chakra CN, Williams V, Bush K, Dyck M, Hirji Z, Kiss A, Larios OE, McGeer A, Moore C, Weiss K, Simor AE, Infection Prevention and Control Canada

Abstract
OBJECTIVE: Point-prevalence surveys for infection or colonization with methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae, carbapenem-resistant Enterobacteriaceae (CREs), and for Clostridium difficile infection (CDI) were conducted in Canadian hospitals in 2010 and 2012 to better understanding changes in the epidemiology of antimicrobial-resistant organisms (AROs), which is crucial for public health and care management.
METHODS: A third survey of the same AROs in adult inpatients in Canadian hospitals with ≥50 beds was performed in February 2016. Data on participating hospitals and patient cases were obtained using standard criteria and case definitions. Associations between ARO prevalence and institutional characteristics were assessed using logistic regression models.
RESULTS: In total, 160 hospitals from 9 of the 10 provinces with 35,018 adult inpatients participated in the survey. Median prevalence per 100 inpatients was 4.1 for MRSA, 0.8 for VRE, 1.1 for CDI, 0.8 for ESBLs, and 0 for CREs. No significant change occurred compared to 2012. CREs were reported from 24 hospitals (15%) in 2016 compared to 10 hospitals (7%) in 2012. Routine universal or targeted admission screening for VRE decreased from 94% in 2010 to 74% in 2016. Targeted screening for MRSA on admission was associated with a lower prevalence of MRSA infection. Large hospitals (>500 beds) had higher prevalences of CDI.
CONCLUSION: This survey provides national prevalence rates for AROs in Canadian hospitals. Changes in infection control and prevention policies might lead to changes in the epidemiology of AROs and our capacity to detect them.

PMID: 30394232 [PubMed - as supplied by publisher]

https://ift.tt/2OvgNYX

Higher Interleukin-7 serum concentrations in patients with cystic fibrosis correlate with impaired lung function.

Related Articles

Higher Interleukin-7 serum concentrations in patients with cystic fibrosis correlate with impaired lung function.

J Cyst Fibros. 2018 Oct 31;:

Authors: Seyfarth J, Sivagurunathan S, Ricken S, Weinreich G, Olbrich L, Taube C, Mayatepek E, Schramm D, Jacobsen M

Abstract
BACKGROUND: Patients with cystic fibrosis (CF) are highly susceptible to infection and colonization of pulmonary epithelia. Repeated and chronic infections may affect disease course and efficacy of host immune protection. Higher Interleukin (IL)-7 serum levels, indicating impaired T-cell response to IL-7, have been described for chronic viral and mycobacterial infections.
METHODS: Time course measures of IL-7 serum concentrations in patients with CF (n = 164; n = 78 for the second time point) and healthy controls (n = 60) were done. CF patients were characterized for disease severity parameters as well as infection status and association with IL-7 serum levels was determined.
RESULTS: CF patients had significantly higher IL-7 serum concentrations as compared to healthy controls (9.79 pg/ml, IQR 6.76-13.6 versus 4.55 pg/ml, IQR 2.76-9.51, p < .001). IL-7 serum levels were negatively correlated with individual CF patient's BMI (r = -0.19, p = .021) and a tendency of increased IL-7 levels in Staphylococcus aureus infected CF patients was found. Linear regression of multiple parameters revealed significant negative correlation of FEV1%pred with IL-7 serum concentrations in patients with CF (ß-coefficient: -0.04, 95% confidence interval [-0.08; -0.003], p = .034). Time course analyses after 1 year +/- 6 months showed increased IL-7 serum levels (time point 1:9.26 pg/ml, IQR 6.94-13.12 time point 2:10.86 pg/ml, IQR 9.14-14.76, p = .016) that correlated negatively with decreased FEV1%pred during CF disease course.
CONCLUSIONS: High IL-7 serum levels were found in CF patients and correlated with impaired lung function during CF disease course. As a candidate biomarker of T-cell dysfunction, higher IL-7 serum level may also indicate worsened immune competence of patients with CF.

PMID: 30389600 [PubMed - as supplied by publisher]

https://ift.tt/2yTjWwQ

Course of colonization by multidrug-resistant organisms after allogeneic hematopoietic cell transplantation.

Related Articles

Course of colonization by multidrug-resistant organisms after allogeneic hematopoietic cell transplantation.

Ann Hematol. 2018 Dec;97(12):2501-2508

Authors: Heidenreich D, Kreil S, Jawhar M, Müller N, Nolte F, Becker KP, Miethke T, Hofmann WK, Klein SA

Abstract
Multidrug-resistant organisms (MDRO) have been developing as an emerging problem in allogeneic hematopoietic cell transplantation (HCT). Since no data are available on the course of MDRO colonization after HCT, we investigated in this retrospective, single-center study, persistence and clearance of MDRO after HCT. From June 2010 to December 2015, 121 consecutive HCT patients were included. Patients received a MDRO screening before conditioning as well as surveillance cultures after HCT. In MDRO-colonized patients, surveillance specimens were taken until MDRO were no longer detectable. Thirty-three patients (27%) were found to be colonized by at least one MDRO at any time point until day 100 post HCT. Day 100 (2-year) non-relapse mortality (NRM) and overall survival (OS) of MDRO-colonized (MDRO+) versus non-colonized (MDRO-) patients were essentially the same. NRM is 15% (21%) versus 15% (24%). Two-year OS is 60 versus 55% for MDRO+ versus MDRO- patients. Out of the 33 MDRO+ patients, 21 cleared the MDRO. Median time to non-detectability of MDRO was 6 months. In 12 patients, the MDRO persisted. There was a significant (p < 0.0001) survival difference between patients who cleared the MDRO versus those with MDRO persistence (2-year OS 80 vs 40%). Except for the length of antibiotic therapy as a potential risk factor for MDRO persistence after HCT, no other conventional factors could be identified. (a) colonization by MDRO per se had no negative impact on the outcome, (b) MDRO can be cleared by the majority of patients after allogeneic HCT, and (c) to increase the probability to clear MDRO, the use of antibiotics in MDRO+ patients should be reviewed critically.

PMID: 30121845 [PubMed - indexed for MEDLINE]

https://ift.tt/2OvgMEn

Effect of spraying of fine water particles on facial skin moisture and viscoelasticity in adult women

Abstract

Background/purpose

It is known that the elderly and adult women with reduction in sebum secretion have reduced skin barrier function, drying of the skin in a low humidity environment is accompanied by physiological distress. As our hypothesis, when fine water particles are sprayed on the skin, the water content of the corneal layer is significantly increased. In the present study, we examined the ability of fine water particles to improve facial skin moisture levels in adult women.

Methods

We examined skin conductance, transepidermal water loss (TEWL), and skin elasticity as an index of skin barrier function at the cheek in 17 healthy adult women in the spraying of fine water particles, in the environment temperature at 24°C and 34.5% relative humidity.

Results

The skin conductance of stratum corneum after 120 minute of spraying, A condition (peak particle size below 0.5 μm) was 119.7 ± 25.1%, B condition (peak particle size 1.8 μm) was 100.4 ± 31.7%, C condition (peak particle size 5.4 μm) was 110.1 ± 25.0%, and the A condition was significantly higher than the B condition. Also, skin elasticity in the A condition tended to be higher value than in the other conditions. Transepidermal water loss (TEWL) after 120 minute of spraying showed a lower value in the A condition than in the other conditions. In the A condition, the skin conductance steadily maintained their initial levels up to 360 minute after spraying.

Conclusion

Especially, by spraying smallest fine water particles, skin barrier function at the cheek was improved. These data indicated that non‐charged fine water particles played an important role on moisten skin in a low humidity environment.

https://ift.tt/2Fh8kJQ

A dose-escalation study of docetaxel, oxaliplatin, and S-1 (DOS) as a first-line therapy for patients with unresectable metastatic gastric cancer

Abstract

Purpose

The aim of this study was to determine the recommended dose (RD) for a docetaxel/oxaliplatin/S-1 (DOS) regimen in patients with unresectable gastric cancer and to preliminarily evaluate its efficacy.

Methods

Previously untreated patients with histologically proven unresectable metastatic gastric cancer were enrolled (n = 16). Docetaxel and oxaliplatin were administered intravenously on day 8 and S-1 was administered orally twice a day on days 1–14. Each cycle was repeated every 3 weeks. Dose-limiting toxicities (DLTs) were evaluated during the first treatment cycle. Three dose escalations of DOS were employed in this study: level 1 (50/100/80 mg/m²), level 2 (50/130/80 mg/m²), and level 3 (60/130/80 mg/m²).

Results

According to the 3 + 3 dose-escalating schedule, we determined that the RD and maximum tolerated dose for this regimen were level 1 and level 2, respectively. The DLTs were grade 3 diarrhea and febrile neutropenia. The overall response rate was 78% (7/9) for patients with measurable lesions and consisted of two complete responses and five partial responses. Five patients underwent conversion surgery. The median follow-up time was 19 months with median survival time and progression-free survival being 19.6 months and 7.6 months, respectively.

Conclusions

The results from this study demonstrated the safety and tolerability of DOS in unresectable metastatic gastric cancer patients and revealed promising preliminary efficacy with a high conversion rate. A phase II trial of DOS regimen using the identified RD is ongoing.

https://ift.tt/2JKS7Lb

A lump on the palate

https://ift.tt/2DqFe8N

In vivo Raman spectroscopic characteristics of different sites of the oral mucosa in healthy volunteers

Abstract

Objectives

Investigate the biochemistry of in vivo healthy oral tissues through Raman spectroscopy. We aimed to characterize the biochemical features of healthy condition in oral subsites (buccal mucosa, lip, tongue, and gingiva) of healthy subjects. More specifically, we investigated Raman spectral characteristics and biochemical content of in vivo healthy tissues on Brazilian population. This characterization can be used to better define normal tissue and improve the detection of oral premalignant conditions in future studies.

Materials and methods

For spectroscopic analysis a Raman spectrometer (Kaiser Optical Systems imaging spectrograph Holospec, f / 1.8i-NIR) coupled with a laser 785 nm, 60 mW was used. Raman measurements were obtained by means of an optical fiber (EMVision fiber optic probe) coupled between the laser and the spectrometer. Three spectra per site were acquired from the lip, buccal mucosa, tongue, and gingiva of ten healthy volunteers. This resulted in 30 spectra per oral sub-site and in total 120 spectra.

Results

We report detailed biochemical information on these subsites and their relative composition based on deconvolution studies of their spectra. Finally, we also report classification efficiency of 61, 83, 41, and 93% for buccal, gingiva, lip, and tongue respectively after applying multivariate statistical tools.

Conclusions

We quantitated the contribution of various biochemicals in terms of percentage, and this will enable comparison not only across anatomical sites but also across studies. Raman spectroscopy can rapidly probe tissue biochemistry of healthy oral regions. Moreover, the study suggests the possibility of using Raman spectroscopy combined with signal processing and multivariate analysis methods to differentiate the oral sites in healthy conditions and compare with pathological conditions in future studies.

Clinical relevance

The spectral characterization of the healthy condition of oral tissues by a noninvasive, label-free, and real-time analytical techniques is important to create a spectral reference for future diagnosis of pathological conditions.

https://ift.tt/2AQyrmg

Analysis of swale factors implicated in pollutant removal efficiency using a swale database

Abstract

Swales are traditional basic open-drainage systems which are able to remove stormwater-borne pollutants. In spite of numerous case studies devoted to their performances, parameters influencing the reduction of pollutant concentrations by swales remain elusive. In order to better characterize them, a database was set up by collecting performance results and design characteristics from 59 swales reported in the literature. Investigations on correlations among pollutant efficiency ratios (ERs) indicated that total trace metals (copper (Cu), zinc (Zn), cadmium (Cd), and lead (Pb)), total suspended solids (TSS), total phosphorus (TP), and total Kjeldahl nitrogen (TKN) exhibited many cross-correlated ERs. High ERs were observed for pollutants including a particulate form such as TSS (median ERs = 56%) and total trace metals (median ERs ≥ 62%), suggesting that these pollutants are efficiently trapped by sedimentation in swale bed and/or filtered within swale soil. Medium to high ERs were found for dissolved trace metals (median ERs ≥ 44%), whereas ERs for nutrient species were lower (median ERs ≤ 30%). The inflow concentration was identified as a major factor correlated to ER for most pollutants. For some pollutants, there is also a trend to get higher ER when the geometrical design of the swale increases the hydraulic residence time. Overall, this database may help to better understand swale systems and to optimize their design for improving pollutant removal.

https://ift.tt/2QoGPyK

Lead uptake by the symbiotic Daucus carota L.– Glomus intraradices system and its effect on the morphology of extra- and intraradical fungal microstructures

Abstract

This work examines the strategies adopted by an arbuscular mycorrhizal symbiotic system to ameliorate environmental Pb stress by examining the concentrations of P, Fe, and Pb in the fungal microstructures and the host's root. In vitro cultures of Ri-T DNA-transformed carrot (Daucus carota L.) roots were inoculated with Glomus intraradices and treated with Pb(NO₃)₂ solution and the extraradical spores and mycelia (S/M) and the root with the vesicles, mycelia, and root cells were subsequently analyzed by polarized energy dispersive x-ray fluorescence (PEDXRF) spectrometry. Upon Pb treatment, within the root, the percentages of mycorrhizal colonization, the vesicles, and mycelia increased as well as the areas of the vesicles and the (extraradical) spores, although the number of spores and arbuscules decreased. The S/M and the mycorrhizal root showed enhanced concentrations of Pb, Fe, and P. These were particularly marked for Fe in the Pb-treated cultures. This indicates a synergistic relationship between the arbuscular mycorrhizal fungus and the host that confers a higher Pb tolerance to the latter by the induction of higher Fe absorption in the host. The intraradical vesicle, mycelia, and arbuscule numbers are interpreted as a "tactic to divert" the intraradical Pb traffic away from the root cells to the higher affinity cell walls of the arbuscular mycorrhizal fungi (AMF) microstructures in the apoplast. The results of this work show that the symbiosis between the AMF G. intraradices and the host plant D. carota distinctly improves the latter's Pb tolerance, and imply that the appropriate metal tolerant host-AMF combinations could be employed in process designs for the phytoremediation of Pb.

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Tribute to Reviewers

https://ift.tt/2AQhGYM

NZDSI Abstracts from the 8–11 August 2018 conference

https://ift.tt/2F8hs3j

Issue Information

https://ift.tt/2AOC7oO

Hydro-electric power in the Panjkora basin at the expense of environmental deterioration and biodiversity loss—immediate action required for mitigation

https://ift.tt/2F7Cb7p

Comparison of the contents of selected elements and pesticides in honey bees with regard to their habitat

Abstract

The inspiration for this study was the anxiety of Warsaw beekeepers, who raised the question whether location of hives in large urban agglomerations results in changes in concentrations of xenobiotics, toxic elements, and micronutrients in honey bees. Preliminary studies required elaboration of the research methodology, as the studied object is characterized by a low degree of homogeneity and the method of sample preparation affects obtained results. From many tested approaches, the use of washed and milled abdomens of the bees is recommended. Results obtained for such prepared samples are slightly lower than for whole bees, but their repeatability is higher, which enables easier interpretation of the trends and comparison of different locations. The contents of selected elements (As, Al, Cd, Co, Cr, Cu, Mn, Pb, and Zn) were compared in bees from urban and rural areas. The studies were supported by pesticides analysis. Also, it was checked whether these substances are accumulated on the surface or inside the bee's body. The research indicates the markers of contamination: Al, As, and Cr on the surface and Cd inside the bodies of honey bees. The location of the hives does not influence significantly the content of "toxic," nutrient metals and metalloids in bees (slightly higher levels of As, Al, Pb, and Cd were found in bees from urban areas). In terms of exposure to these elements and pesticides, the large city environment is not harmful for honey bees.

https://ift.tt/2AOT7vc

Salvage Chemoradiation Therapy for Recurrence After Radical Surgery or Palliative Surgery in Esophageal Cancer Patients

Condition:   Esophageal Cancer
Interventions:   Radiation: Involved field irradiation;   Radiation: Elective field irradiation;   Drug: Paclitaxel;   Drug: Lobaplatin;   Drug: PEG-rhG-CSF
Sponsors:   Chinese Academy of Medical Sciences;   The First Affiliated Hospital with Nanjing Medical University;   Tianjin Medical University Cancer Institute and Hospital;   Anyang Cancer Hospital;   Fujian Cancer Hospital;   Beijing Cancer Hospital;   Hebei Medical University Fourth Hospital
Recruiting

https://ift.tt/2PPJPHL

SHR-1316 in Combination With Chemotherapy in Patients With Esophageal Squamous Cell Cancer

Condition:   Advanced Esophageal Squamous Cell Cancer
Interventions:   Drug: Irinotecan liposome;   Drug: SHR-1316;   Drug: Fluorouracil
Sponsor:   Jiangsu HengRui Medicine Co., Ltd.
Recruiting

https://ift.tt/2RAyM2b

Study of the Efficacy of Lenvatinib Combined With Denosumab in the Treatment of Patients With Predominant Bone Metastatic Radioiodine Refractory Differentiated Thyroid Carcinomas

Condition:   Thyroid Cancer Metastatic
Intervention:   Drug: Lenvatinib + Denosumab
Sponsor:   Centre Leon Berard
Not yet recruiting

https://ift.tt/2PGmKHm

Stretching of the Diaphragm and Cervical Impulse Technique and Its Possible Spirometric Changes

Condition:   Respiratory Capacity
Interventions:   Procedure: Stretching the diaphragm muscle;   Procedure: Impulse technique in rotation of cervical level 3 and 4;   Procedure: Combined technique of diaphragm muscle stretch and cervical rotation impulse technique level 3 and 4
Sponsor:   Cardenal Herrera University
Not yet recruiting

https://ift.tt/2RFe1Tc

Lidocaine to Prevent Cough and Hemodynamic Changes in Tracheal Extubation

Condition:   Lidocaine
Interventions:   Drug: Lidocaine;   Drug: Saline Solution
Sponsor:   Hospital Fernandez
Not yet recruiting

https://ift.tt/2PHjCuz

The characteristics and pivotal roles of triggering receptor expressed on myeloid cells-1 in autoimmune diseases

Publication date: Available online 5 November 2018

Source: Autoimmunity Reviews

Author(s): Sheng Gao, Yongdong Yi, Guojun Xia, Chengyang Yu, Chenmin Ye, Fuyang Tu, Leibin Shen, Wenqian Wang, Chunyan Hua

Abstract

Triggering receptor expressed on myeloid cells-1 (TREM-1) engagement can directly trigger inflammation or amplify an inflammatory response by synergizing with TLRs or NLRs. Autoimmune diseases are a family of chronic systemic inflammatory disorders. The pivotal role of TREM-1 in inflammation makes it important to explore its immunological effects in autoimmune diseases. In this review, we summarize the structural and functional characteristics of TREM-1. Particularly, we discuss recent findings on TREM-1 pathway regulation in various autoimmune diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), inflammatory bowel disease (IBD), type 1 diabetes (T1D), and psoriasis. This receptor may potentially be manipulated to alter the inflammatory response to chronic inflammation and possible therapies are explored in this review.

https://ift.tt/2D68LDK

Target Therapy in SLE

Publication date: Available online 5 November 2018

Source: Autoimmunity Reviews

Author(s): Matthias Schneider

Abstract

The intention of this paper is to review actual developments in target therapy in SLE. Target therapy includes both the objective of intervention and the aim of treatment. The objective should be linked to the pathophysiologic process of SLE; the aim has to be in any case an improved outcome.

The current therapeutic in SLE is guided mostly by secondary prevention. In SLE, besides a BASIC concept with antimalarials, bone and sun protection, vaccination and cardiovascular risk minimising, treatment waits for new manifestations to be started to prevent secondarily damage. With the new treatment target remission, treatment should aim at ensuring long-term survival, preventing organ damage and optimizing health-related quality-of-life by controlling disease activity and minimising comorbidities and drug toxicity. First examples show that some patients are in remission and that those patients have a better outcome. But for treat-to-target a strategy needs to be developed that needs to be evaluated.

https://ift.tt/2Pf0EvS

Dampness and mold hypersensitivity syndrome and vaccination as risk factors for chronic fatigue syndrome

Publication date: Available online 5 November 2018

Source: Autoimmunity Reviews

Author(s): Tamara Tuuminen, Tiina Jääskeläinen, Kirsi Vaali, Olli Polo

https://ift.tt/2D3nFdY

Adrenal Insufficiency in Systematic Lupus Erythematosus (SLE) and Antiphospholipid Syndrome (APS): A Systematic Review

Publication date: Available online 5 November 2018

Source: Autoimmunity Reviews

Author(s): Keum Hwa Lee, HyunJeong Lee, Cheol-hun Lee, Jin Yeong Kim, Jong Min Kim, Se Seung Kim, Seungmin Jeong, In Sung Hwang, Namsoo Kim, Na Eun Kim, Soogeun Shin, Dongkwan Shin, Joo Sang Song, Dong Hyun Shin, Jung Dong Kim, Jeehoon Kim, Yong Seok Lee, Hansung Kang, Dong Ha Kim, So Hyun Moon

Abstract

Background: Adrenal insufficiency (AI) is associated with high morbidity and mortality. The aim of this systematic review was to enhance diagnostic approaches and summarize therapeutic strategies in the management of AI in patients with an underlying prior disease history.

Methods: A literature search of PubMed and EMBASE databases was performed and 91 publications containing 105 cases were included for the final analysis.

Results: The following frequency of clinical signs and symptoms was noted: abdominal pain (39.04%) was the leading symptom, followed by fever (33.33%), vomiting (23.81%), and nausea (19.05%). Antiphospholipid syndrome (APS) was present in 73%, systematic lupus erythematosus (SLE) in 17% of the patients, while 2% had a diagnosis of both, SLE and APS. ACTH stimulation test (ACTHst) was performed in 18% of cases and 76.6% of them were unresponsive towards stimulation. Variable treatment approaches were used: hydrocortisone was most commonly used (38.09%), followed by fludrocortisone (26.67%), prednisolone (20.00%) and volume replacement treatment (11.43%), respectively.

Conclusions: This analysis highlights the importance of an early diagnosis and initiation of therapeutic management when AI is suspected. In line, signs and symptoms related to autoimmune diseases in patients with AI should be reviewed crtitically.

https://ift.tt/2P9niWy

Liver-Associated Immune Abnormalities

Publication date: Available online 5 November 2018

Source: Autoimmunity Reviews

Author(s): Eyal Grunebaum, Yaron Avitzur

Abstract

In recent years, the cross talk between the liver and the immune system is being uncovered, in part by studying liver involvement in primary immune deficiencies (PID) and in part by investigating the alterations of the immune system following orthotic liver transplantation (OLT). Here we review some of the reciprocal interactions between the liver and the immune system. Patients with PID, particularly those involving inherited defects in T and B cells or innate immunity are prone to infections and inflammatory responses that often involve the liver. Omenn's syndrome, familial hemophagocytic lymphohistiocytosis, AIRE, FOXP3 and CD25 deficiencies, common variable immunodeficiency, CD40 ligand deficiency, chronic granulomatous disease and autoimmune lymphoproliferative syndrome are some of the notable PID associated with typical hepatobiliary abnormalities. Knowledge gained from studying these PID together with laboratory and histological evaluations can assist in managing PID-associated liver dysfunction. The liver itself also has important effects on the immune system, as evident from the growing experience with patients surviving OLT. Up to 40% of pediatric patients who receive OLT suffer from post transplantation allergy, autoimmunity, and immune-mediated disorders (PTAA). PTAA is more common after liver and heart transplantations than kidney transplantations. Potential contributing factors for the increased frequency of PTAA after OLT include the age of the patients, the prolonged use of tacrolimus and the reduced regulatory immune function with a shift towards a TH2 immune response. Better understanding of the mechanisms leading to the development of PTAA after OLT will also improve the management of these conditions.

https://ift.tt/2D9w8g3

Arthritis in primary Sjögren's syndrome: Characteristics, outcome and treatment from French multicenter retrospective study

Publication date: Available online 5 November 2018

Source: Autoimmunity Reviews

Author(s): Adrien Mirouse, Raphaèle Seror, Eric Vicaut, Xavier Mariette, Maxime Dougados, Anne-Laure Fauchais, Alban Deroux, Azeddine Dellal, Nathalie Costedoat-Chalumeau, Guillaume Denis, Jérémie Sellam, Jean-Benoît Arlet, Christian Lavigne, Geoffrey Urbanski, Dominique Fischer-Dumont, Abdou Diallo, Olivier Fain, Arsène Mékinian, on behalf of Club Rhumatismes Inflammation and SNFMI

Abstract

Objective

To describe the characteristics and the outcome of primary Sjögren Syndrome (pSS) associated arthritis and to compare the efficacy of different therapeutic regimen.

Methods

We conducted a retrospective study using Club Rhumatisme and Inflammation (CRI) and French Internal Medicine Society (SNFMI) networks. All patients with a diagnosis of pSS and at least one episode of clinical and/or echographic synovitis were included. Patients with synovitis (cases) were compared to pSS patients without synovitis (controls).

Results

57 patients (93% women) were included with a median age of 54 years [45–63]. Patients with synovitis had more frequently lymph node enlargement (12.3% vs. 1.8%, p = .007) and a higher ESSDAI score (8 [[6], [7], [8], [9], [10], [11], [12]] vs. 2 [[1], [2], [3], [4]], p < .0001). There was no difference concerning CRP levels, rheumatoid factor and cyclic citrullinated peptide (CCP)-antibodies positivity. Among 57 patients with synovitis, 101 various treatment courses have been used during the follow-up of 40 [22.5–77] months. First treatment course consisted in steroids alone (3.5%), steroids in association (79%) with hydroxychloroquine (HCQ) (49%), methotrexate (MTX) (35%), rituximab (RTX) (5.3%) or other immunosuppressive drugs (7%). HCQ, MTX, and RTX were associated with a significant reduction of tender and swollen joint count, and a significant steroids-sparing effect. No difference could be shown for the joint response between these treatment regimens.

Conclusion

pSS articular manifestations may include synovitis which could mimic rheumatoid arthritis but differ by the absence of structural damage. Even if the use of HCQ, MTX, and RTX seem to be effective for joint involvement, the best regimen remains to be determined.

https://ift.tt/2PhY7kY

VALIDATION and meta-analysis of kappa index biomarker in multiple sclerosis diagnosis

Publication date: Available online 5 November 2018

Source: Autoimmunity Reviews

Author(s): Paloma Menéndez-Valladares, Maria Isabel García-Sánchez, Myriam Adorna Martínez, Jose Luis García De Veas Silva, Carmen Bermudo Guitarte, Guillermo Izquierdo Ayuso

Abstract

The importance of studying the cerebrospinal fluid (CSF) in Multiple Sclerosis (MS) is included in the last McDonald criteria (2018). The study of oligoclonal IgG bands (OCGB) assay is strongly recommended in some situations in which MS diagnosis is uncertain. New biomarkers are developed during the last years. Kappa free light chains (FLC) can predict conversion to MS in patients with Clinically Isolated Syndrome (CIS).

The aim of this work is to validate the clinical usefulness of the kappa index, and to establish the actual state of knowledge for kappa index as a biomarker of conversion in CIS patients by a meta-analysis. Kappa index seems more relevant than the mere concentration of kappa FLC in CSF.

In the validation study, 334 patients were included; in which 100 were CIS patients. Patients were divided in two groups according kappa index cut-off of 10.62: group 1 (kappa index>10.62); group 2 (kappa index<10.62). In group 1 more patients had positive OCGB, IgG index>0.56 and fulfilled magnetic resonance imaging (MRI) criteria. In contrast, in group 2, more patients showed negative OCGB, IgG index<0.56 and did not fulfilled MRI criteria. While 67.6% of patients from group 1 converted to MS, only 12.5% of patients from group 2 converted to MS. An HR of 6.02 was obtained in the Kaplan-Meier analysis.

In the meta-analysis, 8 studies were finally included. The SROC curve revealed a high diagnostic performance for the kappa index as a MS diagnostic biomarker. Despite heterogeneity found between studies, the global OR revealed a good discriminatory capacity of kappa index.

In conclusion, kappa index has a great clinical sensitivity and specificity as a support in MS diagnosis. High kappa index increase the probability of CIS to MS conversion. A correct sample processing in the preanalytical stage is key to obtain right results and to allow establishing comparison between laboratories.

https://ift.tt/2D4C7Tg

X chromosome and female bias in systemic lupus erythematosus: Focus on population-based evidence

Publication date: Available online 5 November 2018

Source: Autoimmunity Reviews

Author(s): Dongsheng Di, Hui Yuan, Linlin Zhang, Xiaoxiao Wu, Haifeng Pan, Dongqing Ye, Ruixue Leng

https://ift.tt/2D1Pi7r

Scholar : International Journal of Occupational and Environmental Health, Volume 24, Issue 1-2, January - April 2018 is now available online on Taylor & Francis Online

The online platform for Taylor & Francis Online content International Journal of Occupational and Environmental Health, Volume 24, Issue 1-2, January - April 2018 is now available online on Taylor & Francis Online. This new issue contains the following articles: Articles Preferred sampler inlet configurations for collection of aerosolized nano-scale materials John Jankovic, Tracy L. Zontek, Megan Moore, Burton R. Ogle & Scott Hollenbeck Pages: 1-6 | DOI: 10.1080/10773525.2018.1484995 Prevalence and correlates of psychological stress among teachers at a national key comprehensive university in China Wenjun Li & Changgui Kou Pages: 7-16 | DOI: 10.1080/10773525.2018.1500803 A cross-sectional study of retrospectively reported seasonality in native and non-native residents of Chukotka and Turkmenistan Arcady A. Putilov Pages: 17-26 | DOI: 10.1080/10773525.2018.1500804 Original Articles Prevalence of musculoskeletal disorders among Indian railway sahayaks Mohammed Rajik Khan & Nishant Kumar Singh Pages: 27-37 | DOI: 10.1080/10773525.2018.1507187 Articles Digging deeper into the shared variance among safety-related climates: the need for a general safety climate measure Derek M. Hutchinson, Stephanie A. Andel & Paul E. Spector Pages: 38-46 | DOI: 10.1080/10773525.2018.1507867 Variations in perinatal mortality associated with different polluting fuel types and kitchen location in Bangladesh Monjura Khatun Nisha, Ashraful Alam & Camille Raynes-Greenow Pages: 47-54 | DOI: 10.1080/10773525.2018.1507868 Seropositivity in animals and risk of occupational brucellosis among abattoirs personnel associated with poor work practices and absence of safety policy in Egypt Amira M. Zakaria, Salwa F. Ahmed & Mohamed S. Motawae Pages: 55-60 | DOI: 10.1080/10773525.2018.1516839 Using leading and lagging indicators to select safe contractors at the prequalification stage of construction projects Huakang Liang, Shoujian Zhang & Yikun Su Pages: 61-74 | DOI: 10.1080/10773525.2018.1517928 Hoping to have your article read by anyone, anywhere and at any time? Find out more about publishing open access with Ecosystem Health and Sustainability. To update which email alerts you receive, manage your alerts within the My Account area. Unsubscribe from new content alerts for this journal (both new issue and latest article notifications) with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : intitle:laryngeal - new results

Short-Term Swallowing Outcomes Following Type 1 Laryngeal Cleft Injection

AL Miller, CJ Hersh, KE Johnson, CJ Hartnick - International Journal of Pediatric …, 2018

Introduction Interarytenoid injection augmentation at the time of initial diagnostic
endoscopy for aspiration and dysphagia may result in near-immediate improvement
in swallowing function, potentially obviating the need for future formal endoscopic …

[HTML] Laryngeal Dysfunction in Chronic Cough: A Sign for Specific Cough Endotype?

WJ Song - The Journal of Allergy and Clinical Immunology: In …, 2018

The recent recognition of cough hypersensitivity as the key pathophysiologic
mechanism underlying chronic cough 1 has contributed to the opening of a new
window of opportunity in the treatment of chronic persistent cough. Recent clinical …

Assessing the efficacy of ventilation of anesthetized neonatal calves using a laryngeal mask airway or mask resuscitator

L Armstrong, NA Caulkett, SR Boysen, JM Pearson… - Frontiers in Veterinary …, 2018

Calves that have undergone a dystocia are often hypoxic and acidemic, which can
result in reduced vigour and subsequent mortality. Methods of field resuscitation of
apneic newborn calves are often ineffective and therefore underutilized. This proof-of …

[HTML] A rare case of laryngeal carcinoma in pregnancy

HM Teh, MS Razali - The Egyptian Journal of Otolaryngology, 2018

Cancer in pregnancy is uncommon. The ethical problem of managing head and neck
cancer in pregnancy has always been a common issue to ensure the mother and
fetal well-being. Choices for the diagnostic and treatment modalities are crucial to …

[PDF] An objective evaluation of the laryngeal roof

S Sarica, N Yurttutan, N Bilal, S Sagiroglu, FM Yazar - 2018

Aim: The anatomic measurements of the thyroid cartilage, which is an important part
of the laryngeal roof, were calculated using computed tomography (CT) and the data
obtained were compared in two groups of male and female. Material and Methods: A …

Considerations About the Effect of Cough Assist on Laryngeal Function in Neurologic Disease

AM Esquinas, G Fiorentino - Respiratory Care, 2018

We read with interest the work by Andersen et al 1 about transnasal laryngoscopy
during mechanical insufflation-exsufflation in amyotrophic lateral sclerosis (ALS). We
believe the following should be considered.First, the larynx is a complex structure …

Laryngeal traumas in children caused by trampoline accidents

TN Ranneries, J Balle, P Homøe - Ugeskrift for laeger, 2018

Laryngeal trauma is rare in children due to the anatomical placement and the trauma
mechanisms required for injury. Recently the trampoline has become frequent in
Danish households leading to more high-energy laryngeal traumas. This case report …

The Identification of Recurrent Laryngeal Nerve by Injection of Blue Dye into the Inferior Thyroid Artery.

A Salah, M Mamdoh, N Abd-Elhamid - Egyptian Journal of Hospital Medicine, 2018

Background: Thyroidectomy creates a potential risk for injury of the recurrent
laryngeal nerve (RLN). The identification and dissection of the RLN is the gold
standard for preserving its function. Aim of the work: was to evaluate the value of …

[PDF] Oncologic outcomes of transoral laser microsurgery for T3 laryngeal carcinoma: a meta-analysis

H Zhou, D Li, C Zhu - Int J Clin Exp Med, 2018

Laryngeal carcinomas are the second most common type of head and neck tumors,
most of which are squamous cell carcinomas. The specific choice of treatment of T3
laryngeal (glottic or supraglottic) squamous cell carcinoma has been rather …

[HTML] A comparative evaluation of ProSeal laryngeal mask airway, I-gel and Supreme laryngeal mask airway in adult patients undergoing elective surgery: A randomised …

A Singh, AR Bhalotra, R Anand - Indian Journal of Anaesthesia, 2018

Background and Aims: Second-generation supraglottic airway devices are widely
used in current anaesthesia practice. This randomised study was undertaken to
evaluate and compare laryngeal mask airway: ProSeal laryngeal mask airway …

[PDF] AGP1 acts as a biomarker for diagnosis of laryngeal cancer

Y Zhang, Z Wang, X Bai, Y Xu - Int J Clin Exp Pathol, 2018

Background: Laryngeal cancer is a common malignancy of head and neck cancer,
with increasing morbidity and mortality in our country. It is reported that AGP1 can act
as a serum marker for several diseases and cancers. In this study, we evaluated the …

[HTML] Localized subglottic laryngeal amyloidosis: a case report

HMA Tawab, IA Sulaiman - The Egyptian Journal of Otolaryngology, 2018

Amyloidosis is a heterogeneous group of diseases characterized by accumulation of
amyloid protein in different organs of the body. Localized affection of the larynx by
amyloid deposits is a rare event. This is a case of localized laryngeal amyloidosis in …

[HTML] Isolated laryngeal amyloidosis: a case report

S Zainol, M Azman, S Muthusamy - The Egyptian Journal of Otolaryngology, 2018

Background Amyloidosis is extracellular deposition of an amorphous amyloid
substance in various tissues. It can occur in any bodily organ. Clinically, it is divided
into systemic and solitary amyloidosis. Isolated laryngeal amyloidosis is very rare in …

Effects of preoperative cisapride on postoperative aspiration pneumonia in dogs with laryngeal paralysis

J Ogden, D Ovbey, K Saile - Journal of Small Animal Practice

Objectives Retrospective evaluation of a preoperative prokinetic protocol using a
constant‐rate infusion of a serotonin 5‐HT4 receptor agonist, cisapride, and its
association with frequency of postoperative aspiration pneumonia in dogs …

 

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Scholar : ΠΡΟΣΩΠΙΚΟ ΝΕΥΡΟ - νέα αποτελέσματα

[PDF] Αποκατάσταση μετά απο εγκεφαλικό επεισόδιο: Νεότερες νοσηλευτικές παρεμβάσεις

Α ΒΟΓΚΛΗ, ΒΜ ΓΙΟΓΑΚΗ - 2018

… Από την γέφυρα αναδύονται αρκετά εγκεφαλικά νεύρα, το τρίδυμο νεύρο, το απαγωγό
νεύρο, το προσωπικό νεύρο και το οπτικοακουστικό νεύρο. *Παρεγκεφαλίδα: το
μεγαλύτερο τμήμα του οπίσθιου εγκεφάλου. Ευθύνεται για την …

[PDF] Διαχείριση του πόνου στα παιδιά

ΑΕ ΚΟΥΖΙΟΥ, Κ ΠΥΡΓΑ - 2018

… Με τον τρόπο αυτό το νοσηλευτικό προσωπικό δεν διευκολύνει μόνο, αλλά συμβάλλει
στον προγραμματισμό της νοσηλευτικής φροντίδας των παιδιών κατά τη διάρκεια της
νοσηλείας. Page 6. vi Abstract … 10 3.2 Πόνος των νεύρων - ταχύς πόνος και βραδύς πόνος …

[PDF] Βιοψυχοκοινωνικές ανάγκες του χειρουργικού ασθενή και ο ρόλος του κοινοτικού νοσηλευτή στην προαγωγή της υγείας του

Ε ΚΟΥΡΜΠΕΛΗΣ - 2018

… ασθενών που υποβάλλονται σε χειρουργική επέμβαση και ο ρόλος του νοσηλευτικού
προσωπικού στην προαγωγή της υγείας του. Μεθοδολογία … και ιδιαίτερα από το
νοσηλευτικό προσωπικό σχετικά με τις ανάγκες των ασθενών, που …

[PDF] Καισαρική τομή και μητρικός θηλασμός και πως επηρεάζουν την υγεία του παιδιού

Κ ΔΗΜΗΤΡΙΟΥ - 2018

… Μπορεί σε εξαιρετικές περιπτώσεις να τραυματιστεί ελαφρά κάποιο νεύρο, αλλά και αυτό
δεν έχει παρά ασήμαντες επιπτώσεις … Ο σπάνιος ελαφρύς τραυματισμός ενός νεύρου
ή της μήνιγγας μπορεί να προκαλέσει πονοκέφαλο ή/και ζάλη …

[PDF] Λευχαιμία κατά την παιδική ηλικία. Πως επιδρά και πως επηρεάζει την ψυχολογία τους

Σ ΣΕΡΓΙΟΥ, Ε ΑΝΑΣΤΑΣΙΟΥ - 2018

Page 1. ΣΧΟΛΗ ΕΠΑΓΓΕΛΜΑΤ ΤΜΗΜΑ ΝΟ ΠΤΥΧΙΑΚΗ «ΛΕΥΧΑΙΜΙΑ ΚΑΤΑ ΤΗΝ ΠΑΙΔΙΚΗ
ΠΩΣ ΕΠΗΡΕΑΖΕΙ ΤΗΝ Ψ ΦΟΙΤΉΤΡΙΕΣ: ΑΝΑΣΤΑΣΙΟΥ ΕΙΣΗΓΗΤΡΙΑ: 1 Τ.Ε.Ι ΔΥΤΙΚΗΣ
ΕΛΛΑΔΑΣ ΧΟΛΗ ΕΠΑΓΓΕΛΜΑΤΩΝ ΥΓΕΙΑΣ ΚΑΙ ΠΡΟΝΟΙΑΣ ΤΜΗΜΑ ΝΟΣΗΛΕΥΤΙΚΗΣ …

[PDF] Παχυσαρκία στην παιδική ηλικία και ο ρόλος της νοσηλευτικής στο παιδί και στην οικογένεια

Ε ΛΕΜΟΝΟΥ, ΖΩΗ ΜΠΑΡΡΕ - 2018

… ενηλικίωσης. Τέλος, γίνεται λόγος για την υποθαλαμική παχυσαρκία, που δημιουργείται
λόγω βλάβης του υποθαλάμου με αποτέλεσμα να επηρεάζει το νεύρο έτσι ώστε το άτομο
να τρώει ασταμάτητα (Ιατρός & Πλέσσας, 2010). 1.3 Επιδημιολογία …

[PDF] Γνώσεις και ψυχολογικές επιπτώσεις του καρκίνου του μαστού στις γυναίκες: Ποσοτική μελέτη

Μ ΧΡΙΣΤΟΓΕΩΡΓΟΥ, Κ ΜΠΕΡΛΕΜΗ - 2018

… από το σύνδρομο χρόνιου νευροπαθητικού πόνου όπως ο πόνος στο στήθος
Phantom (αισθητική εμπειρία που υπάρχει ακόμα και μετά την απομάκρυνση
του μαστού και είναι οδυνηρή), τη Διαθρακτική νευραλγία (πόνος στην …

[PDF] Φροντιστές υγείας χρόνιων πασχόντων, η ελληνική ιδιαιτερότητα

Α ΑΜΑΣΙΑΔΗ, Σ ΑΜΠΕΛΙΩΤΗ - 2018

… δημόσιων ή ιδιωτικών οργανισμών. Οι ειδικότητες που αφορούν αυτή την κατηγορία μπορεί
να είναι κοινωνικοί λειτουργοί, νοσηλευτές και εκπαιδευμένο προσωπικό. Στην άλλη μορφή
η φροντίδα παρέχεται καθημερινά από ανθρώπους χωρίς κάποια οικονομική αποζημίωση …

 

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