Alternative adsorbents applied to the removal of natural hormones from pig farming effluents and characterization of the biofertilizer

Abstract

Pig farming has a very strong economic importance in Brazil. The residues from this activity are applied to the soil because of their excellent characteristics as biofertilizers. The present study aimed at studying the estrone, 17β-estradiol, and estriol natural hormones, emerging contaminants present in this type of residue that are not mentioned in the current legislation. The characterization of the pig farming effluent presented high concentrations of hormones (mg L⁻¹). The objective was to apply the biosorbents to the removal of the hormones in batch systems directly in the manure heaps without affecting the potential of the effluent as a fertilizer. It was verified that the adsorption of hormones using the rice husk biomass in natura and soybean hull in natura, abundant alternative adsorbents, presented a good capacity of removal of hormones. The presence of the organic materials (rice husk and soybean hull) caused few alterations in the biofertilizer characteristics, demonstrating that these adsorbents present a potential of application in batch treatment systems, with possible applications related to pig farming effluents containing natural hormones.

https://ift.tt/2zfcKdM

Determination of effective half-life of 131 I in patients with differentiated thyroid carcinoma: comparison of cystatin C and creatinine-based estimation of renal function

Abstract

Purpose

Renal function and effective half-life (t_1/2,eff) of I-131 have not been fully elucidated in patients undergoing radioiodine therapy (RAIT) for differentiated thyroid cancer (DTC). Aim of the present analysis was to evaluate the potential of cystatin C-based estimated glomerular filtration rate (eGFR_CysC) in comparison to conventional creatinine (eGFR_Crea) and to verify which methods to determine t_1/2,eff are most accurate to predict t_1/2,eff.

Methods

Forty-eight patients receiving whole-body I-131-scintigraphy were included. eGFR_CysC was compared to eGFR_Crea with regard to accuracy of t_1/2,eff prediction. Three different methods (i.e. blood-based, gamma camera-based and probe-based) and two protocols with either three (short period,SP; up to 42 h) or four (long period,LP; up to 114 h) time points were compared using the Akaike's information criterion.

Results

The eGFR_CysC measurement is more likely than eGFR_Crea in predicting the t_1/2,eff. High correlation coefficients were found between t_1/2,eff assessed by gamma camera and probe measurements and blood-based determination revealed lower values. Patients with normal eGFR showed higher values of t_1/2,eff of LP compared to SP.

Conclusions

eGFR_CysC should be included in further study protocols. As camera and probe measurements lead to almost superimposable results, one of the methods is expendable. Blood-based results of t_1/2,eff were lower, presumably due to unspecific iodine retention, whereas the lower correlation with renal function may be caused by individual differences in intestinal iodine resorption. SP-protocols up to 42 h after I-131 administration are sufficient to determine t_1/2,eff. Further studies are necessary for specific recommendations regarding I-131 activity reduction during RAIT in patients with DTC and renal insufficiency.

https://ift.tt/2Qg7ePy

Determination of effective half-life of 131 I in patients with differentiated thyroid carcinoma: comparison of cystatin C and creatinine-based estimation of renal function

Abstract

Purpose

Renal function and effective half-life (t_1/2,eff) of I-131 have not been fully elucidated in patients undergoing radioiodine therapy (RAIT) for differentiated thyroid cancer (DTC). Aim of the present analysis was to evaluate the potential of cystatin C-based estimated glomerular filtration rate (eGFR_CysC) in comparison to conventional creatinine (eGFR_Crea) and to verify which methods to determine t_1/2,eff are most accurate to predict t_1/2,eff.

Methods

Forty-eight patients receiving whole-body I-131-scintigraphy were included. eGFR_CysC was compared to eGFR_Crea with regard to accuracy of t_1/2,eff prediction. Three different methods (i.e. blood-based, gamma camera-based and probe-based) and two protocols with either three (short period,SP; up to 42 h) or four (long period,LP; up to 114 h) time points were compared using the Akaike's information criterion.

Results

The eGFR_CysC measurement is more likely than eGFR_Crea in predicting the t_1/2,eff. High correlation coefficients were found between t_1/2,eff assessed by gamma camera and probe measurements and blood-based determination revealed lower values. Patients with normal eGFR showed higher values of t_1/2,eff of LP compared to SP.

Conclusions

eGFR_CysC should be included in further study protocols. As camera and probe measurements lead to almost superimposable results, one of the methods is expendable. Blood-based results of t_1/2,eff were lower, presumably due to unspecific iodine retention, whereas the lower correlation with renal function may be caused by individual differences in intestinal iodine resorption. SP-protocols up to 42 h after I-131 administration are sufficient to determine t_1/2,eff. Further studies are necessary for specific recommendations regarding I-131 activity reduction during RAIT in patients with DTC and renal insufficiency.

https://ift.tt/2Qg7ePy

What can food-image tasks teach us about anorexia nervosa? A systematic review

Abstract

A salient feature of anorexia nervosa (AN) is the persistent and severe restriction of food, such that dietary intake is inadequate to maintain a healthy body weight. Experimental tasks and paradigms have used illness-relevant stimuli, namely food images, to study the eating-specific neurocognitive mechanisms that promote food avoidance. This systematic review, completed in accordance with PRISMA guidelines, identified and critically evaluated paradigms involving images of food that have been used to study AN. There were 50 eligible studies, published before March 10^th 2018, identified from Medline and PsychINFO searches, and reference screening. Studies using food image-based paradigms were categorised into three methodologic approaches: neuropsychology, neurophysiology, and functional magnetic resonance imaging (fMRI). Paradigms were reviewed with a focus on how well they address phenomena central to AN. Across tasks, differences between individuals with AN and healthy peers have been identified, with the most consistent findings in the area of reward processing. Measuring task performance alongside actual eating behaviour, and using experimental manipulations to probe causality, may advance understanding of the mechanisms of illness in AN.

https://ift.tt/2SB71Ys

Themes arising during implementation consultation with teams applying family-based treatment: a qualitative study

Abstract

Background

This study describes themes arising during implementation consultation with teams providing Family-Based Treatment (FBT) to adolescents with eating disorders.

Methods

Participants were implementation teams (one lead therapist, one medical practitioner and one administrator) at four sites. These teams agreed to support the implementation of FBT, and participated in monthly consultation calls which were audio-recorded, transcribed verbatim and coded for themes. Twenty percent of the transcripts were double-coded to ensure consistency. Fundamental qualitative description guided the sampling and data collection.

Results

Twenty-five (average per site = 6) transcripts were coded using thematic content analysis. Six major themes emerged: 1) system barriers and facilitators 2) the role of the medical practitioner, 3) research implementation, 4) appropriate cases, 5) communication, and 6) program impact.

Conclusions

Implementation themes aligned with previous research examining the adoption of FBT, and provide additional insight for clinical programs seeking to implement FBT, emphasizing the importance of role clarity, and team communication.

https://ift.tt/2zj4vNX

Doxercalciferol Alleviates Bone Deteriorations and Cartilage Degeneration in Aging Mice

Exp Clin Endocrinol Diabetes
DOI: 10.1055/a-0754-1956

Background Age-related bone deteriorations are the common endocrine disorders in the elderly population, leading to an increased risk of fractures. Therefore, effective treatment strategies provide a way to prevent bone loss and improve the quality of life in the elderly population. The present study aimed to investigate the anti-osteoporotic effects of doxercalciferol (DOX) in aging mice. Methods Bone metabolism-related markers were measured by ELISA assay. The expression of bone formation and resorption-related genes was performed by RT-qPCR analysis. Hematoxylin and eosin (H&E) and Safranin O staining were performed to analyze the trabecular bone and cartilage degeneration. Results Aging resulted in urine Ca excretion, a decrease in bone Ca content and reduction of biomechanical strength in mice. We also found that the level of PTH was increased in aging mice, while DOX administration markedly down-regulated serum PTH in aging mice. H&E and Safranin O staining showed that DOX protected against aging-induced bone loss and cartilage regeneration in the tibia from aging mice. Furthermore, DOX treatment resulted in an increase in Runx2, osterix and Col1a1 mRNA expression and a decrease in Ctsk, MMP-9 and CAII mRNA expression in the tibia from aging mice. Conclusion These findings indicated that DOX had a beneficial effect on age-related bone deteriorations in aging mice by promoting osteoblast activity and cartilage regeneration and inhibiting osteoclast-specific genes expression.
[...]

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

https://ift.tt/2Q4YD1Q

Broadening the operative field: the extent of surgery beyond the patient`s informed consent (the so-called therapeutic exception)

W artykule omówiono przesłanki tzw. wyjątku terapeutycznego, uregulowanego w art. 35 ustawy z dnia 5 grudnia 1996 r. o zawodach lekarza i lekarza dentysty. Konstrukcja ta pozwala lekarzowi, w trakcie operacji, na zmianę zakresu zabiegu ponad zgodę wyrażoną przez pacjenta. Ponadto poruszono kwestię tzw. zgody antycypacyjnej oraz warunki jej skuteczności oraz wyjaśniono, czy w wypadku realizacji przesłanek wyjątku terapeutycznego lekarz jedynie może dokonać odpowiedniej modyfikacji czynności operacyjnych, czy też jest to jego obowiązek. Wskazano również, że w omawianej sytuacji lekarz nie może powoływać się na tzw. stan wyższej konieczności. Prezentowane treści zostały wzbogacone o przedstawienie konkretnych spraw sądowych i ich rozstrzygnięć.

https://ift.tt/2qnoIOm

Inter-arm differences in blood pressure among subjects with disseminated atherosclerosis scheduled for vascular surgery

Background: The measurement of blood pressure (BP) is routinely performed in perioperative care. The reliability of results is essential for the implementation of treatment ensuring haemodynamic stability. The aim of the present study was to assess the prevalence and basic determinants of inter-arm BP differences among patients with advanced peripheral atherosclerosis undergoing vascular surgical procedures of the lower limbs. Methods: The prospective study was carried out in patients scheduled for elective lower limb vascular surgery. One-time non-invasive BP measurements were performed sequentially on the brachial arteries of both upper extremities before the induction of anaesthesia, maintaining the shortest possible interval between measurements. The systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP) were recorded. Results: The results of 173 patients (including 123 men aged 67 ± 8 years) were analysed. In 16 (9.3%) patients, an inter-arm difference in BP was already observed during the preoperative examination. SBP and DBP was higher in the right limb in 86 (49.7%) an 80 (46.3%) patients, respectively. Moreover, the medians of inter-arm differences in SBP, DBP and MAP were 9 (IQR 4–17), 5 (IQR 3–10) and 7 mm Hg (IQR 3–12), respectively. An evaluation of the determinants of BP differences related to the presence of additional diseases demonstrated that patients with arterial hypertension were characterised by higher SBP and MAP disproportions (P = 0.04 and P = 0.01). Conclusions: In the population of patients with disseminated atherosclerosis, the inter-arm differences in BP substantially exceed the measurement error limits and are likely to be associated with arterial hypertension. If in doubt about BP disproportions, intraoperative monitoring of BP should be recommended using an invasive method on the limb presenting higher non-invasively measured values.

https://ift.tt/2QaqQnU

Risk factors for occurrence of failed interscalene brachial plexus blocks for shoulder arthroscopy using 20 mL 0.5% ropivacaine: a randomised trial

Background: The red blood cell distribution width index (RDW) is one of several parameters routinely analysed in peripheral blood counts. The aim of the study was to assess the usefulness of RDW in the prediction of in-hospital mortality in patients undergoing high-risk gastroenterological surgery. Methods: Prospective observation covered 229 patients who underwent surgery, for whom the risk of cardiovascular complications was high due to the type of procedure. The patient's individual risk was assessed using the criteria of the American Society of Anesthesiologists (ASA-PS). Peripheral blood for morphological examination was collected preoperatively. The following parameters of the red blood cell system were evaluated: red blood cell count (RBC), haemoglobin (Hgb), haematocrit (Hct), mean corpuscular volume (MCV), RDW expressed as a standard deviation (SD) and a coefficient of variation (CV). The occurrence of hospital death was the main endpoint. Results: Patients who died had had statistically significantly lower RBC, Hgb and Hct values, as well as higher RDW-SD and RDW-CV values. Both the preoperative RDW-SD and RDW-CV values predicted the outcome, respectively: AUC_RDW-SD = 0.744 (95% CI: 0.683–0.799; P RDW-CV = 0.762 (95% CI: 0.702–0.816; P RDW-SD = 1.21; P RDW-CV = 1.62; P = 0.01), even after adjustment for individual risk and other erythrocyte parameters. Conclusion: RDW is a valuable screening predictor of in-hospital mortality in patients undergoing high-risk gastroenterological surgery, regardless of the estimated individual risk and the value of other erythrocyte parameters. Evaluation of the RDW may be helpful in the identification of patients requiring correction of haematological disorders in the pre-operative period, as well as, in particular, surveillance in the perioperative period.

https://ift.tt/2qnoB5o

Use of noninvasive mechanical ventilation with pressure support guaranteed with average volume in de novo hypoxaemic respiratory failure. A pilot study

Background: This study was designed to determine the results associated with the use of noninvasive mechanical ventilation (NIV) using the BiPAP S/T-AVAPS ventilation strategy in subjects with mild to moderate de novo hypoxaemic respiratory failure. Methods: This is a prospective study that includes subjects with de novo hypoxaemic respiratory failure (not produced by acute exacerbations of COPD, chronic lung disease, or congestive heart failure) with mild to moderate PaO₂/FiO₂, who were admitted to the Intensive Care Unit (ICU) of Santa Maria Clinic in Guayaquil, Ecuador. Subjects were divided into two groups and compared according to their PaO₂/FiO₂: higher than 100 and up to 200 mm Hg (moderate ARDS) or between 200 and 300 mm Hg (mild ARDS) (both groups were ventilated with the BiPAP S/T-AVAPS strategy). A value of P Results: A total of 38 subjects were analysed in this study. The total rate of intubation was 34.2% while the mortality rate was 28.9%. Significant differences were observed when comparing success versus failure in exhaled tidal volumes (P = 0.04), peak inspired pressure (P 2 (P 2 (P 2/FiO₂ (P P P = 0.029) measured at baseline and at 12-hour, 24-hour and 48-hour intervals. Conclusion: The BiPAP S/T-AVAPS ventilatory mode can be used in subjects with de novo hypoxaemic respiratory failure with special vigilance concerning exhaled tidal volumes and inspired pressure.

https://ift.tt/2QbLyUn

Peri-anaesthetic cardiac arrest with administration of enalapril, spironolactone and β-blocker

none

https://ift.tt/2qk11GN

Postoperative pain after spinal surgery in the paediatric population

Introduction: Postoperative pain is a major aftereffect of surgery. Especially severe occurs after extensive operations within the spine. The goal of the study was to investigate the laboratory predictive factors of intensive postoperative pain in children undergoing extensive surgery Patients and methods: We recruited 41 children, age median 13 years (IQR:10-15 years) undergoing extensive spine surgery. The subjects were divided into two groups based on the intensity of postoperative pain measured using the 10-point numerical rating scale (NRS), visual analog scale (VAS) or faces pain scale-revised (FPS-R). Patients with a score of 5 or higher were included in the study group and those with NRS of less than 5 were included in the control group. We collected detailed clinical and laboratory data before, during and after surgery. Results: The highest intensity of pain was observed in the first 6 hours after surgery. The postoperative pain was associated with a higher drop in hemoglobin concentration and hematocrit level in peri-operative period (p=0.006 and p=0.019 respectively) as well as higher changes in mean arterial pressure during surgery. Additionally, we found that children with intensive pain had higher total protein concentration after surgery. Conclusions: We reported that the drop in hemoglobin and hematocrit level, fluctuation in mean arterial pressure as well as total protein concentration could be useful prognostic factors of early postoperative pain.

https://ift.tt/2QazYJk

A case report of inadvertent intranasal submucosal injection of concentrated epinephrine with no long-term sequelae

https://ift.tt/2qjCUYM

How do you stop unwanted hair growth?

Unwanted hair growth on the body or face has a range of causes linked to hormones. Some growth is typical and has no links to conditions that cause hirsutism. Natural treatments include diet changes and weight management. Medical treatments can also help. Learn more about excessive or unwanted hair in women here.

https://ift.tt/2RpyE5G

Scholar : These new articles for Cogent Geoscience are available online

The online platform for Taylor & Francis Online content New for Cogent Geoscience and online now on Taylor & Francis Online: Research Article strike-slip deformation in the inkisi formation, brazzaville, republic of congo | Miyouna Timothée, Nkodia Hardy Medry Dieu-Veill, Essouli Olivier Florent, Dabo Moussa, Boudzoumou Florent & Delvaux Damien | Robin John Armit Reviewing editor: This is the author accepted version which has not been proofed or edited To update which email alerts you receive, manage your alerts within the My Account area. Unsubscribe from new content alerts for this journal (both new issue and latest article notifications) with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

ZnO:SBA-15 Nanocomposites for Potential Use in Sunscreen: Preparation, Properties, Human Skin Penetration and Toxicity

Aim: We evaluated the effects of the incorporation of zinc oxide (ZnO) nanoparticles in a mesoporous matrix, aiming to improve the textural, structural and morphological properties and verify their safety so that they can be applied in sunscreen cosmetics. Materials and Methods: ZnO nano­particles were incorporated into an ordered mesoporous silica matrix known as Santa Barbara Amorphous-15 (SBA-15), using post-synthesis methodology. The resulting nanocomposites were characterized using X-ray diffraction, small angle X-ray scattering, N₂ adsorption-desorption isotherms, Fourier transform infrared spectroscopy, scanning electron microscopy and predicted in vitro sun protector factor (SPF) estimation. Effectiveness and safety were evaluated by antimicrobial activity, in vitro cell toxicity and non-invasive multi-photon tomography with fluorescence lifetime imaging. Results: The structure of the nanocomposites was similar to that of SBA-15, with little perturbation caused by ZnO incorporation. Nanocomposites had an increased in vitro SPF, reduced cytotoxic activity and favourable antimicrobial properties compared to ZnO. ZnO:SBA-15 nanocomposites exhibited no measurable toxicity when applied to human skin in vivo. Conclusion: Due to their suitable physicochemical properties and improved safety compared to bare ZnO nanoparticles, the ZnO:SBA-15 nanocomposites show promise for use in cosmetic applications.
Skin Pharmacol Physiol 2019;32:32–42

https://ift.tt/2RpQ5CO

In vivo Human Skin Penetration of the UV Filter Ethylhexyl Triazone: Effect of Lipid Microparticle Encapsulation

Background/Aims: The data available on the skin permeability of ethylhexyl triazone (EHT), a widely used high-molecular-weight (823.1-Da) UV filter, are scarce and obtained only via in vitro studies. Therefore, we evaluated in vivo the penetration of EHT in human stratum corneum by the tape stripping technique. Moreover, the effect of EHT encapsulation in lipid microparticles (LMs) on its diffusion through the stratum corneum was examined. Methods: LMs loaded with EHT were prepared using glyceryl behenate and phosphatidylcholine. Creams containing EHT free or encapsulated in LMs in conjunction with the two most commonly used UV filters, octyl methoxycinnamate (OMC) and butyl methoxydibenzoylmethane (BMDBM), were applied to human volunteers and the fraction of the applied sunscreen dose having penetrated into different stratum corneum layers was measured. Results and Conclusion: For the cream with the nonencapsulated sunscreen agent, the percentage of the applied EHT dose diffused into the stratum corneum was 21.9 ± 4.9%, not significantly different from that of the smaller-molecular-weight OMC (22.2 ± 7.6%) and BMDBM (20.5 ± 3.7%). A marked (45.7%) and statistically significant reduction in the in vivo skin penetration of EHT was attained with the cream containing microencapsulated EHT. The decreased percutaneous penetration provided by the LMs should favor the efficacy of EHT and limit potential toxicological risks.
Skin Pharmacol Physiol 2019;32:22–31

https://ift.tt/2PvH26k

The Influence of Breast Cancer on the Distribution of Cherry Angiomas on the Anterior Thoracic Wall: A Case Series Study

Background/Aims: Cherry angiomas (CAs) are one of the most common vascular manifestations of the skin. By and large, these benign lesions often only represent an aesthetic problem. In the literature, few authors have focused on the pathogenesis of these lesions, and some risk factors have been identified, such as the presence of cutaneous and non-skin neoplasias. In this study, the correlation between the distribution of CAs and breast cancer was investigated. Methods: We carried out a study whereby 50 women with unilateral breast cancer and the presence of CAs on the anterior thoracic wall were evaluated, with a particular focus on the difference in the number of CAs between the two haemithoraces. The data was elaborated using the Wilcoxon signed-rank test in order to evaluate whether there was a statistical significance in the distribution of CAs. Results: In 31 patients we found that the number of CAs was greater on the cancerous breast than on the contralateral one (p value #x3c;0.0001). This was confirmed both in the group of patients suffering from ductal breast cancer and in the group with early invasive breast tumours. Conclusion: It is not clear whether CAs develop prior to or following breast cancer, indicating the possibility that this cutaneous manifestation could take on a predictive, prognostic development or represent only an epiphenomenon. Further in-depth studies into the pathogenesis of CAs and the relationship with breast cancer could lead to noteworthy diagnostic-therapeutic advances.
Dermatology

https://ift.tt/2qlM8E4

Scholar : Journal of Natural History, Volume 52, Issue 35-36, September - September 2018 is now available online on Taylor & Francis Online

The online platform for Taylor & Francis Online content Journal of Natural History, Volume 52, Issue 35-36, September - September 2018 is now available online on Taylor & Francis Online. This new issue contains the following articles: Articles Descriptions of two new genera, six new species and three new records of Anthozoa (Cnidaria) from the Sea of Marmara Oscar Ocaña & Melih Ertan Çinar Pages: 2243-2282 | DOI: 10.1080/00222933.2018.1526345 New species of Nasutopedia from cloud forests of the Neotropical region (Hymenoptera: Apidae: Tapinotaspidini) Antonio J.C. Aguiar Pages: 2283-2300 | DOI: 10.1080/00222933.2018.1527962 Diet of tropical insectivorous birds in lowland Malaysian rainforest Mohammad Saiful Mansor, Nurul Ashikin Abdullah, Muhammad Rasul Abdullah Halim, Shukor Md. Nor & Rosli Ramli Pages: 2301-2316 | DOI: 10.1080/00222933.2018.1534015 First record of the whip-lash squid, Mastigoteuthis agassizii Verrill, 1881 (Mollusca: Cephalopoda: Mastigoteuthidae) in the Subarctic Atlantic, with notes on its morphology and biology Alexey V. Golikov, Rushan M. Sabirov, Martin E. Blicher, Gudmundur Gudmundson, Olga L. Zimina & Denis V. Zakharov Pages: 2317-2329 | DOI: 10.1080/00222933.2018.1536229 The Picture of Dorian Gray: shell corrosion allows freshwater and brackish-water gastropods to masquerade as empty shells Kazuo Yamazaki Pages: 2331-2338 | DOI: 10.1080/00222933.2018.1537408 First records of parasitoidism by Sarcophagidae flies (Diptera) on three amphibian species in Mexico Flor G. Vázquez-Corzas, Adriana Sandoval-Comte, Patricia Hernández-López, Sergio Ibáñez-Bernal & Eduardo Pineda Pages: 2339-2350 | DOI: 10.1080/00222933.2018.1535674 Hoping to have your article read by anyone, anywhere and at any time? Find out more about publishing open access with Ecosystem Health and Sustainability. To update which email alerts you receive, manage your alerts within the My Account area. Unsubscribe from new content alerts for this journal (both new issue and latest article notifications) with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Trial Evaluating the Tolerance and Safety of Durvalumab - RT Combination for Treatment in SCCHN

Condition:   HNSCC
Intervention:   Drug: Durvalumab
Sponsors:   Groupe Oncologie Radiotherapie Tete et Cou;   UNICANCER;   Center Eugene Marquis
Not yet recruiting

https://ift.tt/2Jtt9zY

Cosmetics, Vol. 5, Pages 64: Hydration and Barrier Properties of Emulsions with the Addition of Keratin Hydrolysate

Cosmetics, Vol. 5, Pages 64: Hydration and Barrier Properties of Emulsions with the Addition of Keratin Hydrolysate

Cosmetics doi: 10.3390/cosmetics5040064

Authors: Pavel Mokrejš Jana Pavlačková Dagmar Janáčová Matouš Huťťa

Although keratin hydrolysates (KH) are added to skin care agents, detailed studies on the moisturising effects of KH are lacking. The aim of this study is to test whether adding KH into an ointment base (OB) heighten hydration of the skin and diminish transepidermal loss of water (TEWL). Formulations containing 2%, 4%, and 6% of KH (based on OB weight) were prepared. Hydration, TEWL and skin pH were measured; intervals of measurements were as follows: 1, 2, 3, 4, 24 and 48 h. Testing was carried out on 10 men. In terms of hydration, supplementing the OB with 2% KH is optimal, as an 11–19% increase occurs in hydration of stratum corneum (SC). All the formulations with added KH as tested caused TEWL to decline after application. Keratin hydrolysate makes for an excellent occlusive; adding it to OB results in a 30–50% reduction in TEWL after application. KH functions as a humectant as well, as it helps to bind water from the lower layers of the epidermis to the SC. Formulations with additions of 2–6% of KH were stable in structure and did not cause phase separation even after 6 months storage.

https://ift.tt/2RrbE5Z

Activation of the language control network in bilingual visual word recognition

Publication date: Available online 31 October 2018

Source: Cortex

Author(s): David Peeters, Flora Vanlangendonck, Shirley-Ann Rueschemeyer, Ton Dijkstra

Abstract

Research into bilingual language production has identified a language control network that subserves control operations when bilinguals produce speech. Here we explore which brain areas are recruited for control purposes in bilingual language comprehension. In two experimental fMRI sessions, Dutch-English unbalanced bilinguals read words that differed in cross-linguistic form and meaning overlap across their two languages. The need for control operations was further manipulated by varying stimulus list composition across the two experimental sessions. We observed activation of the language control network in bilingual language comprehension as a function of both cross-linguistic form and meaning overlap and stimulus list composition. These findings suggest that the language control network is shared across bilingual language production and comprehension. We argue that activation of the language control network in language comprehension allows bilinguals to quickly and efficiently grasp the context-relevant meaning of words.

https://ift.tt/2SwpwgN

Game Changer: Oral tranexamic acid (TA) in the treatment of melasma: A retrospective analysis

Publication date: Available online 31 October 2018

Source: Journal of the American Academy of Dermatology

Author(s): Eden Lake

https://ift.tt/2Q8V0I8

Game Changer: Oral tranexamic acid (TA) in the treatment of melasma: A retrospective analysis

Publication date: Available online 31 October 2018

Source: Journal of the American Academy of Dermatology

Author(s): Eden Lake

https://ift.tt/2qinl3y

Game Changer: Oral tranexamic acid (TA) in the treatment of melasma: A retrospective analysis

Publication date: Available online 31 October 2018

Source: Journal of the American Academy of Dermatology

Author(s): Eden Lake

https://ift.tt/2Q9g2Xk

Game Changer: Dupilumab therapy provides clinically meaningful improvement in patient-reported outcomes (PROs): A phase IIb, randomized, placebo-controlled, clinical trial in adult patients with moderate to severe atopic dermatitis (AD)

Publication date: Available online 31 October 2018

Source: Journal of the American Academy of Dermatology

Author(s): Eden Lake

https://ift.tt/2qlzTaj

Erratum

Dermatology 2018;234:1

https://ift.tt/2P1p387

Glucose metabolism in patients with psoriasis

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2Q7bfpb

Risk factors for treatment failure in scabies: a cohort study

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2qn184t

16th Indonesian Society of Dermatology and Venereology Annual Meeting Together with the 23rd Asian–Australasian Regional Conference of Dermatology, Surabaya, Indonesia

Dermatologic Therapy, EarlyView.


https://ift.tt/2yHiiy4

Topical urea in skincare: A review

Dermatologic Therapy, EarlyView.


https://ift.tt/2OgOi11

Increased Mortality and Morbidity in Patients with Chronic Hypoparathyroidism: A population based study

Clinical Endocrinology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2Rrs4vn