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Πέμπτη 27 Σεπτεμβρίου 2018

Tender Nodules and Swollen Red Legs: Challenge

No abstract available

https://ift.tt/2xT5aF3

Diabetic Pulmopathy: A New Clinical Challenge for Diabetology

Exp Clin Endocrinol Diabetes 2018; 126: 590-591
DOI: 10.1055/a-0715-2743



© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Full text



https://ift.tt/2Qh3RHD

Reduced Anterolateral Thigh Flap Donor-Site Morbidity Using Incisional Negative Pressure Therapy

10-1055-s-0038-1672126_180107-1.jpg

J reconstr Microsurg
DOI: 10.1055/s-0038-1672126

Background Primary closure of the donor-site after harvest of a large anterolateral thigh flap (ALT) is associated with significant morbidity. Incisional negative pressure therapy (INPT) may decrease complications in high-risk incisions. This study assessed if the incidence of complications after primary closure of the ALT flap donor-site decreases with INPT. Methods Retrospective cohort study of a prospectively maintained database including patients who underwent upper and lower limb reconstruction, using an ALT free flap with primary closure of the donor-site. Two groups were defined: primary closure and INPT (study group) and primary closure with traditional dressings (control group). Nonparametric statistics were employed to identify prognostic factors, p < 0,05. Results Fifty-eight free ALT flaps in 58 patients (study group n = 28; control group n = 30) were included. Median flap width and length were 9 cm (range: 5–14) and 25 cm (range: 10–48), respectively. Median follow-up was 19 months (range: 3–78 months). No significant differences in age or flap size were identified in both groups (p > 0.05). The global complication rate was 7.14% (n = 2) in the INPT group, and 37% (n = 11) in the control group (p = 0.007). The study group had a lower dehiscence and skin necrosis rate (p < 0.05). Multivariate logistic regression analysis showed IPNT was associated with a significant reduction of donor-site complications (p = 0.006), especially in patients with defects > 8 cm (p = 0.003). Conclusions In this cohort study the use of INPT significantly reduced the donor-site morbidity after ALT flap harvest.
[...]

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text



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The Psychological Wellbeing Outcomes of Nonpharmacological Interventions for Older Persons with Insomnia Symptoms: A Systematic Review and Meta-Analysis

Nonpharmacological treatment of insomnia in older persons has been associated with reduced insomnia symptoms and increased psychological wellbeing. This systematic review and meta-analysis examined whether nonpharmacological interventions can promote wellbeing indicators in older persons who experience insomnia symptoms and investigated the components of these interventions. Twenty studies met inclusion criteria. Psychological wellbeing outcomes included symptoms of depression, anxiety, mental health-related quality of life, and fatigue.

https://ift.tt/2NJLiPj

The anatomy of the superficial temporal artery in patients with unilateral microtia.

This is a retrospective study that evaluated the anatomical distribution of the superficial temporal artery (STA) in supply of the temporoparietal fascial (TPF) flap for use in unilateral microtia patients undergoing reconstruction. We aimed to determine if embryologic arrest of pharyngeal arch development would lead to aberrant STA which impedes reliable harvest of the TPF flap in patients requiring microtia repair.

https://ift.tt/2QeWHnb

Association of Hypothyroidism With Nonmelanoma Skin Cancer in the Multiethnic Cohort Population-Based Study

No abstract available

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Reconstruction of a Deep Cutaneous Lip Defect Involving the Nasal Sill

No abstract available

https://ift.tt/2xQaYio

Photobiomodulation therapy before futsal matches improves the staying time of athletes in the court and accelerates post-exercise recovery

Abstract

This study aimed to analyze PBMT effects on futsal player's performance and recovery in a non-controlled field environment. It is a randomized, triple-blinded, placebo-controlled, crossover clinical trial. The research included six professional athletes and in each match phototherapy treatments were performed before matches (40 minutes), blood samples were collected before treatments, and samples immediately after the end of the matches and 48 h after. Furthermore, videos were analyzed to quantify the time athletes spent on the pitch and the distance they covered. PBMT was performed at 17 sites of each lower limb (40 mins before matches), employing a cluster with 12 diodes (4 laser diodes of 905 nm, 4 LEDs of 875 nm, and 4 LEDs of 640 nm, 30 J per site). The performance of the athlete could be quantified considering the time on the pitch and the distance covered; the biochemical markers evaluated were creatine kinase, lactate dehydrogenase, blood lactate, and oxidative damage to lipids and proteins. PBMT significantly increased the time of staying in the pitch and a significant improvement in all the biochemical markers evaluated. No statistically significant difference was found for the distance covered. Pre-exercise PBMT can enhance performance and accelerate recovery of high-level futsal players.



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Surface electromyography after lower level laser therapy application on skeletal muscles in individuals with heart failure

Abstract

The purpose of this study was to investigate the effects of low-level laser therapy (LLLT) applied before a fatigue protocol through the effects on the electrical activation in the quadriceps muscle in patients with HF. Fourteen patients with the diagnosis of heart failure (HF) were selected for this double-blind, crossover type clinical trial. These participants have attended to a familiarization, LLLT, and placebo sessions, totaling three visits. The LLLT was applied in the quadriceps muscle (850 nm, 5 J per diode). The fatigue protocol consisted of concentric and eccentric isokinetic contractions (cc/ec) until exhaustion or up to 50 cc/ec. The muscular fatigue was evaluated with surface electromyography, by the analysis of integral, median frequency, and entropy. Only one application of LLLT is not able to decrease skeletal muscle activation in patients with HF. There was no reduction of muscle fatigue among the proposed protocols. Single LLLT session has no effect on the reduction of skeletal muscle fatigue in patients with HF.



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Ist Operation und anschließende Radiochirurgie gleichwertig mit Operation und Ganzhirnbestrahlung erst im Rezidiv bezüglich Gesamtüberleben und intrazerebraler Tumorkontrolle bei Patienten mit 1–4 Hirnmetastasen?



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Carboplatin verbessert nicht die Wirksamkeit der adjuvanten Radiotherapie bei fortgeschrittenen kutanen Plattenepithelkarzinomen der Kopf-Hals-Region



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Die kapazitive Hyperthermie scheint das Schmerzansprechen bei der palliativen Bestrahlung von schmerzhaften Knochenmetastasen zu verbessern



https://ift.tt/2zzwY3b

Risk of Hepatocellular Carcinoma After Treatment With Entecavir vs Tenofovir for Chronic Hepatitis B

This cohort study uses data from the Korean National Health Insurance Service database to compare the risk of hepatocellular cancer associated with entecavir vs tenofovir disoproxil fumarate in patients receiving long-term treatment for chronic hepatitis B infection.

https://ift.tt/2R5oo3a

Clinical Benefit of Cancer Drugs With FDA Approval Based on Single-Arm Trials

This study uses the European Society of Medical Oncology Magnitude of Clinical Benefit Scale to evaluate the clinical benefit of anticancer drugs that gained approval by the US Food and Drug Administration based on single-arm rather than randomized clinical trials.

https://ift.tt/2N7mBXQ

Tenofovir vs Entecavir for Hepatocellular Carcinoma Prevention in Patients With Chronic Hepatitis B

Current guidelines for the treatment of chronic hepatitis B (CHB) recommend as first-line line therapy entecavir (ETV), tenofovir disoproxil fumarate (TDF), or tenofovir alafenamide fumarate. Both ETV and TDF achieve similar rates of hepatitis B virus (HBV) DNA suppression and alanine aminotransferase normalization over time and have an excellent safety record. However, ETV and TDF have not been directly compared except in patients with decompensated cirrhosis; to our knowledge, no other head-to-head randomized trials exist. Yet, there is strong interest in understanding if one drug might be superior to the other in specific clinical settings or subpopulations. In the absence of randomized comparator trials, high-quality "real world" cohorts can be quite informative. In this issue of JAMA Oncology, Choi and colleagues report the results of 2 retrospective cohort studies of patients with CHB from Korea that evaluated the association between the type of nucleoside or nucleotide analogue and the development of hepatocellular carcinoma (HCC). Using both a large administrative data set (24 156 patients with CHB and 984 with HCC) and a tertiary hospital-based cohort (2701 patients with CHB and 154 with HCC), the authors found that the risk of HCC was consistently about 35% lower in those treated with TDF than in those treated with ETV. This association persisted even when stratified by cirrhosis status and after very thorough adjustment for available confounders. These striking findings raise the question of whether the current CHB guidelines should be updated to reflect this observed superior anticancer benefit of TDF over ETV.

https://ift.tt/2R5olV2

Immune Checkpoint Blockade and Tumor-Specific Vaccine for Patients With Incurable HPV-16 Cancer

This phase 2 clinical trial examines whether the efficacy of nivolumab is amplified through treatment with ISA 101, a synthetic long-peptide human papillomavirus 16 vaccine, in patients with incurable human papillomavirus 16–positive cancer.

https://ift.tt/2N4oaWE

Scholar : Archives of Physiology and Biochemistry, Volume 124, Issue 4, October 2018 is now available online on Taylor & Francis Online

Taylor & Francis Online - The new journals and reference work platform for Taylor & Francis
The online platform for Taylor & Francis Online content

Archives of Physiology and Biochemistry, Volume 124, Issue 4, October 2018 is now available online on Taylor & Francis Online.



This new issue contains the following articles:

Articles

Fibrotic and apoptotic markers alteration in ovariectomised rats: addition of swimming training preserves lung architecture
Faeze Daghigh, Alireza Alihemmati, Pouran Karimi, Parisa Habibi & Naser Ahmadiasl
Pages: 286-291 | DOI: 10.1080/13813455.2017.1396347


Effects of chronic aspartame consumption on MPTP-induced Parkinsonism in male and female mice
Shaimaa Nasr Amin, Sherif Sabry Hassan & Laila Ahmed Rashed
Pages: 292-299 | DOI: 10.1080/13813455.2017.1396348


Decreased serum microRNA-21 level is associated with obesity in healthy and type 2 diabetic subjects
Samira Ghorbani, Roya Mahdavi, Behnam Alipoor, Ghodratollah Panahi, Ensieh Nasli Esfahani, Farideh Razi, Mohhammad Taghikhani & Reza Meshkani
Pages: 300-305 | DOI: 10.1080/13813455.2017.1396349


The microbial metabolite indole-3-propionic acid improves glucose metabolism in rats, but does not affect behaviour
Anders Abildgaard, Betina Elfving, Marianne Hokland, Gregers Wegener & Sten Lund
Pages: 306-312 | DOI: 10.1080/13813455.2017.1398262


Original Article

Hypolipidemic and cardioprotective effects of Ulva lactuca ethanolic extract in hypercholesterolemic mice
Intissar Kammoun, Hichem Ben Salah, Hajer Ben Saad, Boutheina Cherif, Mickaël Droguet, Christian Magné, Choumous Kallel, Ons Boudawara, Ahmed Hakim, Neji Gharsallah & Ibtissem Ben Amara
Pages: 313-325 | DOI: 10.1080/13813455.2017.1401641


Reduced soluble Toll-like receptors 2 in type 2 diabetes
Emanuela Zaharieva, Tsvetelina Velikova, Adelina Tsakova & Zdravko Kamenov
Pages: 326-329 | DOI: 10.1080/13813455.2017.1401642


Articles

Two dopaminergic genes, DRD4 and SLC6A3, are associated with body mass index in a Colombian sample of young adults
Yeimy González-Giraldo, Martha L. Trujillo & Diego A. Forero
Pages: 330-334 | DOI: 10.1080/13813455.2017.1401643


Screening of analgesic activity of Tunisian Urtica dioica and analysis of its major bioactive compounds by GCMS
Raouia Dhouibi, Dorsaf Moalla, Kamilia Ksouda, Maryem Ben Salem, Serria Hammami, Zouheir Sahnoun, Khaled Mounir Zeghal & Hanen Affes
Pages: 335-343 | DOI: 10.1080/13813455.2017.1402352


Original Article

Lack of effects of myo-inositol on metabolism of primary rat adipocytes
Tomasz Szkudelski, Iwona Hertig & Katarzyna Szkudelska
Pages: 344-350 | DOI: 10.1080/13813455.2017.1408659


The effect of oxidative stress on the progression of Hashimoto's thyroiditis
Ihsan Ates, Mehmet Fettah Arikan, Mustafa Altay, Fatma Meric Yilmaz, Nisbet Yilmaz, Dilek Berker & Serdar Guler
Pages: 351-356 | DOI: 10.1080/13813455.2017.1408660


Arterial stiffness, plasma atherogenic index and soluble cell adhesion molecules in healthy young adults with reduced physical activity
Mariana G. Bacelova, Julia G. Nikolova, Tania Deneva & Petar F. Nikolov
Pages: 357-360 | DOI: 10.1080/13813455.2017.1408661


Effect of oral supplementation of composite leaf extract of medicinal plants on biomarkers of oxidative stress in induced diabetic Wistar rats
Brahm Kumar Tiwari, Abu Baker Abidi, Syed Ibrahim Rizvi & Kanti Bhooshan Pandey
Pages: 361-366 | DOI: 10.1080/13813455.2017.1411369


Rutin hydrate ameliorates cadmium chloride-induced spatial memory loss and neural apoptosis in rats by enhancing levels of acetylcholine, inhibiting JNK and ERK1/2 activation and activating mTOR signalling
Ghada A. Abdel-Aleem & Eman F. Khaleel
Pages: 367-377 | DOI: 10.1080/13813455.2017.1411370


Effect of certain non-steroidal anti-inflammatory drugs on the paraoxonase 2 (PON2) in human monocytic cell line U937
Ayla Solmaz Avcıkurt & Oğuzhan Korkut
Pages: 378-382 | DOI: 10.1080/13813455.2017.1411371


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Photobiomodulation with single and combination laser wavelengths on bone marrow mesenchymal stem cells: proliferation and differentiation to bone or cartilage

Abstract

Tissue engineering aims to take advantage of the ability of undifferentiated stem cells to differentiate into multiple cell types to repair damaged tissue. Photobiomodulation uses either lasers or light-emitting diodes to promote stem cell proliferation and differentiation. The present study aimed to investigate single and dual combinations of laser wavelengths on mesenchymal stem cells (MSCs). MSCs were derived from rabbit iliac bone marrow. One control and eight laser irradiated groups were designated as Infrared (IR, 810 nm), Red (R, 660 nm), Green (G, 532 nm), Blue (B, 485 nm), IR–R, IR–B, R–G, and B–G. Irradiation was repeated daily for 21 days and cell proliferation, osseous, or cartilaginous differentiation was then measured. RT-PCR biomarkers were SOX9, aggrecan, COL 2, and COL 10 expression for cartilage and ALP, COL 1, and osteocalcin expression for bone. Cellular proliferation was increased in all irradiated groups except G. All cartilage markers were significantly increased by IR and IR–B except COL 10 which was suppressed by IR–B combination. ALP expression was highest in R and IR groups during osseous differentiation. ALP was decreased by combinations of IR with B and with R, and also by G alone. R and B–G groups showed stimulated COL 1 expression; however, COL 1 was suppressed in IR–B, IR–R, and G groups. IR significantly increased osteocalcin expression, but in B, B–G, and G groups it was reduced. Cartilage differentiation was stimulated by IR and IR–B laser irradiation. The effects of single or combined laser irradiation were not clear-cut on osseous differentiation. Stimulatory effects on osteogenesis were seen for R and IR lasers, while G laser had inhibitory effects.



https://ift.tt/2QcEjet

Heterogeneity of Astrocytic and Neuronal GLT-1 at Cortical Excitatory Synapses, as Revealed by its Colocalization With Na+/K+-ATPase α Isoforms

Abstract
GLT-1, the major glutamate transporter, is expressed at perisynaptic astrocytic processes (PAP) and axon terminals (AxT). GLT-1 is coupled to Na+/K+-ATPase (NKA) α1–3 isoforms, whose subcellular distribution and spatial organization in relationship to GLT-1 are largely unknown. Using several microscopy techniques, we showed that at excitatory synapses α1 and α3 are exclusively neuronal (mainly in dendrites and in some AxT), while α2 is predominantly astrocytic. GLT-1 displayed a differential colocalization with α1–3. GLT-1/α2 and GLT-1/α3 colocalization was higher in GLT-1 positive puncta partially (for GLT-1/α2) or almost totally (for GLT-1/α3) overlapping with VGLUT1 positive terminals than in nonoverlapping ones. GLT-1 colocalized with α2 at PAP, and with α1 and α3 at AxT. GLT-1 and α2 gold particles were ∼1.5–2 times closer than GLT-1/α1 and GLT-1/α3 particles. GLT-1/α2 complexes (edge to edge interdistance of gold particles ≤50 nm) concentrated at the perisynaptic region of PAP membranes, whereas neuronal GLT-1/α1 and GLT-1/α3 complexes were fewer and more uniformly distributed in AxT. These data unveil different composition of GLT-1 and α subunits complexes in the glial and neuronal domains of excitatory synapses. The spatial organization of GLT-1/α1–3 complexes suggests that GLT-1/NKA interaction is more efficient in astrocytes than in neurons, further supporting the dominant role of astrocytic GLT-1 in glutamate homeostasis.

https://ift.tt/2IkcrCH

Scholar : Journal of Natural History, Volume 52, Issue 31-32, August - August 2018 is now available online on Taylor & Francis Online

Taylor & Francis Online - The new journals and reference work platform for Taylor & Francis
The online platform for Taylor & Francis Online content

Journal of Natural History, Volume 52, Issue 31-32, August - August 2018 is now available online on Taylor & Francis Online.



This new issue contains the following articles:

Articles

The first vertebrate fossil from Socotra Island (Yemen) is an early Holocene Egyptian fruit bat
Kay Van Damme, Petr Benda, Dirk Van Damme, Peter De Geest & Irka Hajdas
Pages: 2001-2024 | DOI: 10.1080/00222933.2018.1510996


A long-term survey of spring monarch butterflies in north-central Florida
Lincoln P. Brower, Ernest H. Williams, Kelly Sims Dunford, James C. Dunford, Amy L. Knight, Jaret Daniels, James A. Cohen, Tonya Van Hook, Emily Saarinen, Matthew J. Standridge, Samantha W. Epstein, Myron P. Zalucki & Stephen B. Malcolm
Pages: 2025-2046 | DOI: 10.1080/00222933.2018.1510057


Short Communication

Activity patterns and habitat use of pudu deer (Pudu puda) in a mountain forest of south-central Chile
Alfredo H. Zúñiga & Jaime E. Jiménez
Pages: 2047-2054 | DOI: 10.1080/00222933.2018.1510995


Articles

First record of Orbopercularia lichtensteini (Peritrichia: Operculariidae) attached to a hemipteran, Corisella edulis (Nepomorpha: Corixidae), in Hidalgo, Mexico, with notes on its cytology and distributional patterns
Ricardo Mariño-Pérez, Rodrigo Macip-Ríos & Rosaura Mayén-Estrada
Pages: 2055-2070 | DOI: 10.1080/00222933.2018.1515379


The family Leucospidae (Hymenoptera: Chalcidoidea) from the South of Saudi Arabia, with the first report of the genus Micrapion and description of Leucospis arabica sp. nov.
Neveen S. Gadallah, Ahmed M. Soliman, Usama M. Abu El-Ghiet, Tarek Y. Elsheikh & Hathal M. Al Dhafer
Pages: 2071-2096 | DOI: 10.1080/00222933.2018.1510557


Seven new species of the genus Pseudostegana (Diptera: Drosophilidae) from South-west China, with DNA barcoding information
Lu Gong & Hongwei Chen
Pages: 2097-2119 | DOI: 10.1080/00222933.2018.1515381


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TAS 102 in Combination With Ramucirumab in Advanced, Refractory Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma

Conditions:   Gastric Adenocarcinoma;   Gastroesophageal Junction Adenocarcinoma;   Gastric Cancer
Interventions:   Drug: TAS 102;   Drug: Ramucirumab 10 MG/ML Intravenous Solution [CYRAMZA]
Sponsor:   H. Lee Moffitt Cancer Center and Research Institute
Not yet recruiting

https://ift.tt/2N6PKT1

Diagnostic Accuracy of Human Transcriptional Activator(MYB) Expression by ELISA Technique Versus Immmunohistochemistry in Detecting Salivary Gland Carcinomas

Conditions:   Malignant Neoplasm of Salivary Gland;   Benign Neoplasm of Salivary Gland
Intervention:   Device: enzyme linked immunosorbent assay (ELISA)
Sponsor:   Cairo University
Not yet recruiting

https://ift.tt/2R1Qe05

Laser-assisted photodynamic therapy for actinic keratosis: A systematic review and meta-analysis

Publication date: Available online 27 September 2018

Source: Journal of the American Academy of Dermatology

Author(s): Theresa Steeb, Justin Gabriel Schlager, Christoph Kohl, Thomas Ruzicka, Markus V. Heppt, Carola Berking

Abstract
Background

Photodynamic therapy (PDT) is an effective intervention for actinic keratosis (AK) and field-cancerization. Ablative fractional laser may facilitate the delivery of photosensitizers and thereby improve the effects of PDT.

Objective

To summarize the current evidence on the efficacy and safety of laser-assisted PDT.

Methods

We performed a systematic literature research in Medline, Embase, and CENTRAL and hand-searched pertinent trial registers for eligible randomized controlled trials (RCTs). Results from individual studies were pooled using a random-effects model. The risk of bias was estimated with the Cochrane Risk of Bias Tool and the quality of evidence of the outcomes with the GRADE approach.

Results

Out of 817 records initially identified, 7 RCTs were included in the qualitative analysis and 4 in the meta-analysis. Laser-assisted PDT showed significantly higher clearance rates compared to PDT monotherapy (risk ratio 1.33, 95% CI 1.24 to 1.42, I2=25%, p<0.01). There was no difference in pain intensity between laser-assisted PDT and other interventions (mean difference 0.31, 95% CI to 0.12 to 0.74, I2=0%, p=0.16). The included studies showed a high risk of bias.

Limitations

The clinical heterogeneity of included studies.

Conclusion

Laser-assisted PDT is more efficient but not more painful than PDT or laser treatment only.



https://ift.tt/2OTOWCV

Results of a nationwide epidemiologic survey of autosomal recessive congenital ichthyosis and ichthyosis syndromes in Japan

Publication date: Available online 26 September 2018

Source: Journal of the American Academy of Dermatology

Author(s): Michiko Kurosawa, Ritei Uehara, Atsushi Takagi, Yumi Aoyama, Keiji Iwatsuki, Masayuki Amagai, Masaki Nagai, Yosikazu Nakamura, Yutaka Inaba, Kazuhito Yokoyama, Shigaku Ikeda

Background

Autosomal recessive congenital ichthyosis (ARCI) and ichthyosis syndrome (IS) are rare genetic skin disorders.

Objective

To estimate the number of patients with ARCI and IS in Japan and clarify the clinicoepidemiologic features of these diseases.

Methods

We performed a nationwide survey of patients treated for ARCI or IS during January 2005-December 2009. We developed diagnostic criteria and conducted a primary survey in a stratified random sample of Japanese hospitals to quantify the number of outpatients and inpatients with ARCI or IS. We performed a secondary survey of clinicoepidemiologic features in positive cases.

Results

The estimated number of patients receiving treatment for ARCI and IS during 2005-2009 was 220 (95% confidence interval [CI] 180-260). The estimated disease distribution was as follows: 95 (95% CI 80-110) patients with nonbullous congenital ichthyosiform erythroderma, 30 (95% CI 20-40) with lamellar ichthyosis, 15 (95% CI 10-20) with harlequin ichthyosis, and 85 (95% CI 50-120) with IS.

Limitations

Patients with a mild case of the disease might not have visited a dermatology department, potentially causing underestimation of affected patients.

Conclusion

We report the estimated number of patients with ARCI and IS in Japan and sex differences in the age distribution.



https://ift.tt/2OfqlLH

Attenuating anger and aggression with neuromodulation of the vmPFC: a simultaneous tDCS-fMRI study

Publication date: Available online 27 September 2018

Source: Cortex

Author(s): Gadi Gilam, Rany Abend, Guy Gurevitch, Alon Erdman, Halen Baker, Ziv Ben-Zion, Talma Hendler

Abstract

Angry outbursts during interpersonal provocations may lead to violence and prevails in numerous pathological conditions. In the anger-infused Ultimatum Game (aiUG), unfair monetary offers accompanied by written provocations induce anger. Rejection of such offers relates to aggression, whereas acceptance to anger regulation. We previously demonstrated the involvement of the ventro-medial prefrontal cortex (vmPFC) in accepting unfair offers and attenuating anger during an aiUG, suggestive of its role in anger regulation. Here, we aimed to enhance anger regulation by facilitating vmPFC activity during anger induction, using anodal transcranial direct current stimulation (tDCS) and simultaneously with functional Magnetic Resonance Imaging to validate modulation of vmPFC activity. In a cross-over, sham-controlled, double-blind study, participants (N=25) were each scanned twice, counterbalancing sham and active tDCS applied during administration of the aiUG. Outcome measures included the effect of active vs. sham stimulation on vmPFC activity, unfair offers' acceptance rates, self-reported anger, and aggressive behavior in a subsequent reactive aggression paradigm. Results indicate that active stimulation led to increased vmPFC activity during the processing of unfair offers, increased acceptance rates of these offers, and mitigated the increase in self-reported anger following the aiUG. We also noted a decrease in subsequent aggressive behavior following active stimulation, but only when active stimulation was conducted in the first experimental session. Finally, an exploratory finding indicated that participants with a stronger habitual tendency to use suppression as an emotion regulation strategy, reported less anger following the aiUG in the active compared to sham stimulation conditions. Findings support a potential causal link between vmPFC functionality and the experience and expression of anger, supporting vmPFC's role in anger regulation, and providing a promising avenue for reducing angry and aggressive outbursts during interpersonal provocations in various psychiatric and medical conditions.



https://ift.tt/2xGgq8w

Rest on it: Awake quiescence facilities insight

Publication date: Available online 27 September 2018

Source: Cortex

Author(s): Michael Craig, Georgina Ottaway, Michaela Dewar

Abstract

Many scientific discoveries have been explained by a sudden gaining of insight with regards to an ongoing problem. Insight is characterised by a mental restructuring of acquired information, from which new explicit knowledge can be drawn, leading to qualitative changes in behaviour. Extended sleep facilitates the gaining of insight, possibly because it is conducive to the stabilisation and restructuring of new memory representations via consolidation. Research shows that a brief period of awake quiescence (quiet resting), too, can support consolidation: people remember more new memories if they quietly rest for several minutes after encoding than if they engage in a task involving ongoing sensory input after encoding. However, it remains unknown whether awake quiescence inspires insight. Using a number-based problem-solving task (the Number Reduction Task – 'NRT'), we reveal that, like sleep, awake quiescence facilitates the rapid gaining of insight: young adults were more than twice as likely to demonstrate new explicit knowledge of a hidden solution to the NRT if initial exposure to this task was followed by 10 minutes of awake quiescence than an unrelated perceptual task. These findings indicate that, at least for the NRT, the development of insight is not restricted to sleep but can be achieved via a brief period of awake quiescence. Thus, contrary to conventional wisdom and theories, when faced with a novel problem we may not always need to 'sleep on it' to find a novel solution, simply 'resting on it' may be enough.



https://ift.tt/2ORMxIM

Regeneration of Pancreatic β-Islet Cells in a Type-II Diabetic.

Related Articles

Regeneration of Pancreatic β-Islet Cells in a Type-II Diabetic.

Case Rep Endocrinol. 2018;2018:6147349

Authors: Jones EC, Rylands JC, Jardet CL

Abstract
A case report is presented in which a type-II diabetic patient significantly improved his dysfunctional β-islet cells using a combination of a strenuous exercise program, cyclical ketogenic diet, and oral GABA/probiotic supplementation. The patient was diagnosed with type-II diabetes at the age of 41 which then progressed through a typical series of treatment changes over 14 years. Treatment periods consisted of metformin therapy alone for 4 years followed by a metformin/glyburide combination therapy for 6 years, and eventually an insulin/metformin combination therapy for 4 years. One year after the initiation of insulin, the patient increased the level of strenuous physical activity (hiking and weight lifting) and adopted a ketogenic diet. Oral GABA and probiotic supplementation were also initiated at the age of 52.7. By the age of 55, the patient no longer required any insulin and is currently being managed with metformin alone. C-peptide values indicate a functional improvement of the β-islet cells during the time of insulin/GABA/probiotic treatment.

PMID: 30254769 [PubMed]



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Scholar : Θυρεοειδής - νέα αποτελέσματ

Μοριακή μελέτη παθήσεων θυρεοειδούς αδένα

Ε Πούλιος - 2018
… Επιστημονικό πεδίο. Ιατρική & Επιστήμες Υγείας. Λέξεις-κλειδιά. Θυρεοειδής αδένας;
miRNAs; Αλληλούχιση νέας γενιάς; real-time PCR; Θηλώδης καρκίνος θυρεοειδούς. Χώρα.
Ελλάδα. Γλώσσα. Ελληνικά. Άλλα στοιχεία. 140 σ., εικ., πιν., γραφ …
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Scholar : ΓΛΩΣΣΙΤΙΣ - νέα αποτελέσματα

Synchronic Occurrence of Erythema and Benign Migratory Glossitis in Patients with Down Syndrome: A Case Report

YVP Bastos, PIDA Melo, LTDC Silva, VSA Cruz… - Oral Surgery, Oral Medicine …, 2018
A 16-year-old boy attended the clinic of dentistry for patients with special needs,
complaining of toothache and gingival bleeding. In the anamnesis, the person-in-
charge reported that the patient-birth-related-pregnancy was complicated and the …
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Desquamative Gingivitis: Challenges in the Diagnosis

LA Oliveira, PL Freitas, NH Ferreira, JNR Assunção… - Oral Surgery, Oral Medicine …, 2018
Page 1. SYNCHRONIC OCCURRENCE OF ERYTHEMA AND BENIGN MIGRATORY
GLOSSITIS IN PATIENTS WITH DOWN SYNDROME: A CASE REPORT. YANN
VICTOR PAIVA BASTOS, PEDRO IGOR DOS ANJOS MELO …
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Amelogenesis Imperfecta: a Case Report

PL Freitas, GO Cruz, LA Oliveira, NH Ferreira… - Oral Surgery, Oral Medicine …, 2018
Page 1. SYNCHRONIC OCCURRENCE OF ERYTHEMA AND BENIGN MIGRATORY
GLOSSITIS IN PATIENTS WITH DOWN SYNDROME: A CASE REPORT. YANN
VICTOR PAIVA BASTOS, PEDRO IGOR DOS ANJOS MELO …
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Ameloblastic Fibroma: a Case Report

EM De Carvalho, FK Horikawa, L Da Guimaraes… - Oral Surgery, Oral Medicine …, 2018
Page 1. SYNCHRONIC OCCURRENCE OF ERYTHEMA AND BENIGN MIGRATORY
GLOSSITIS IN PATIENTS WITH DOWN SYNDROME: A CASE REPORT. YANN
VICTOR PAIVA BASTOS, PEDRO IGOR DOS ANJOS MELO …
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Pleomorphic Adenoma of Minor Salivary Glands: a Case Report

IJC Neto, MACL Jucá, IAP Da Silva, MBP Santos… - Oral Surgery, Oral Medicine …, 2018
Page 1. SYNCHRONIC OCCURRENCE OF ERYTHEMA AND BENIGN MIGRATORY
GLOSSITIS IN PATIENTS WITH DOWN SYNDROME: A CASE REPORT. YANN
VICTOR PAIVA BASTOS, PEDRO IGOR DOS ANJOS MELO …
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Actinic Prurigo of the Lower Lip: Report of an Atypical Case

FTL Barbosa, AF Lopes, NDL Costa, AC Batista… - Oral Surgery, Oral Medicine …, 2018
Page 1. SYNCHRONIC OCCURRENCE OF ERYTHEMA AND BENIGN MIGRATORY
GLOSSITIS IN PATIENTS WITH DOWN SYNDROME: A CASE REPORT. YANN
VICTOR PAIVA BASTOS, PEDRO IGOR DOS ANJOS MELO …
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Occurrence of Severe Bone Dysplasia, Supernumerary Teeth, and C2-C3 Vertebral Fusion

M Peralta-Mamani, BG Duarte, Á Terrero-Pérez… - Oral Surgery, Oral Medicine …, 2018
Skip to Main Content …
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[PDF] 1Department of Family Medicine, University of Health Science, İstanbul Educational Research Hospital, 2Department of Emergency Medicine, Bahçelievler State …

Y Sezgin, S Becel
… spasticity, clonus, and also personality change, restlessness, dementia,
memory loss, vibration and position sense loss with taste, smell and vi- sion
disorders [4]. Orthostatic hypotension, impotence, urinary retention as well …
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[HTML] Candid-CL GEL Uses

CCL GEL
… metronidazole potentiates the effect of indirect anticoagulants; disulfiram
may develop acute psychosis and impaired consciousness; lansoprazole
possible glossitis, stomatitis and / or the appearance of dark color language; …
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[PDF] Novel Compounds

J Adams, L Yiqian - US Patent App. 15/979,729, 2018
US20180258132A1 - Novel Compounds - Google Patents. Novel Compounds. Download
PDF Info. Publication number US20180258132A1. US20180258132A1 US15979729
US201815979729A US2018258132A1 US 20180258132 …
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Scholar : ΜΕΝΙΕΡΕ - νέα αποτελέσματα

Tinnitus suppression using electrical stimulation

H Olze, AJ Szczepek, U Reich, S Gräbel, F Uecker - Current Directions in Biomedical …, 2018
AbstractTinnitus is a phantom sound perceived only by the affected person.
Although the causes for tinnitus may be very diverse (eg hearing loss,
cardiovascular diseases, diabetes, Meniere's disease, otosclerosis), they all …
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[PDF] Method of transporting an agent across blood-brain, blood-cochlear or blood-cerebrospinal fluid barrier

RD Kopke, RA Towner - US Patent App. 15/760,779, 2018
… In some embodiments, the subject is a human patient suffering from an otologic
disease selected from the group consisting of prebycusis, prebystatsis,
noise-induced hearing loss, Meniere's disease, labyrinthitis, vestibular …
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[PDF] Oral Suspension Formulations of Esclicarbazepine Acetate

TC de Vasconcelos, RC de CAMPOS COSTA… - US Patent App. 15/785,890, 2018
… and myotonia. Exemplary vestibular disorders include tinnitus or other inner
ear/cochlear excitability related diseases, such as, for example, neuronal loss,
hearing loss, sudden deafness, vertigo, and Meniere's disease. One …
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[PDF] Methods for controlled proliferation of stem cells/generating inner ear hair cells using 3-(pyridin-2-yl)-1h-indol-2-ol based compounds

C Loose, W MCLEAN, HD Melissa - US Patent App. 15/949,780, 2018
US20180256590A1 - Methods for controlled proliferation of stem cells / generating
inner ear hair cells using 3-(pyridin-2-yl)-1h-indol-2-ol based compounds - Google
Patents. Methods for controlled proliferation of stem cells …
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[PDF] Specific interleukin-15 (il-15) antagonist polypeptide and uses thereof for the treatment of inflammatory and auto-immune diseases

E Mortier, D MEGHNEM, S MORISSEAU, Y Jacques - US Patent App. 15/754,664, 2018
… diabetes (type 1), interstitial cystitis, juvenile arthritis, Kawasaki syndrome,
Lambert-Eaton syndrome, leukocytoclastic vasculitis, lichen planus, lichen
sclerosus, ligneous conjunctivitis, linear IgA disease (LAD), lupus (SLE) …
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20 Cysteine/Glutathione Deficiency: A Significant and Treatable Corollary of Disease

SC De Rosa, P Ghezzi, KV Lemley, B Sahaf, JP Andrus… - … Use of N-Acetyl Cysteine in …, 2018
Page 347. 20 Cysteine/Glutathione Deficiency: A Significant and Treatable Corollary
of Disease Pietro Ghezzi, Kevin V. Lemley, James P. Andrus, Stephen C. De Rosa,
Arne Holmgren, Dean Jones, Farook Jahoor, Richard Kopke …
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[PDF] Methods for the treatment of tinnitus induced by cochlear excitotoxicity

M Guitton, JL Puel, R Pujol, J Ruel, J Wang - US Patent App. 15/813,571, 2018
US20180256514A1 - Methods for the treatment of tinnitus induced by cochlear
excitotoxicity - Google Patents. Methods for the treatment of tinnitus induced by cochlear
excitotoxicity. Download PDF Info. Publication number US20180256514A1 …
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Recombinant bacterial host cell for protein expression

PJ Bassett, DP Humphreys, PM Patel - US Patent App. 15/959,498, 2018
US20180258457A1 - Recombinant bacterial host cell for protein expression - Google
Patents. Recombinant bacterial host cell for protein expression. Download PDF Info.
Publication number US20180258457A1. US20180258457A1 …
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Compositions and methods related to scavenger particles

L Hawthorne, J Dodgson - US Patent App. 15/738,954, 2018
US20180256747A1 - Compositions and methods related to scavenger particles - Google
Patents. Compositions and methods related to scavenger particles. Download PDF Info.
Publication number US20180256747A1. US20180256747A1 …
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