Impact of Genomic Assay Testing and Clinical Factors on Chemotherapy Use After Implementation of Standardized Testing Criteria

AbstractBackground.For clinically appropriate early‐stage breast cancer patients, reflex criteria for Oncotype DX ordering ("the intervention") were implemented at our comprehensive cancer center, which reduced time‐to‐adjuvant chemotherapy initiation. Our objective was to evaluate Oncotype DX ordering practices and chemotherapy use before and after implementation of the intervention.Materials and Methods.We examined medical records for 498 patients who had definitive breast cancer surgery at our center. The post‐intervention cohort consisted of 232 consecutive patients who had Oncotype DX testing after reflex criteria implementation. This group was compared to a retrospective cohort of 266 patients who were diagnosed and treated prior to reflex criteria implementation, including patients who did and did not have Oncotype DX ordered. Factors associated with Oncotype DX ordering pre‐ and post‐intervention were examined. We used multivariate logistic regression to evaluate factors associated with chemotherapy receipt among patients with Oncotype DX testing.Results.The distribution of Oncotype DX scores, the proportion of those having Oncotype DX testing (28.9% vs. 34.1%) and those receiving chemotherapy (14.3% vs. 19.4%), did not significantly change between pre‐ and post‐intervention groups. Age ≤65 years, stage II, grade 2, 1–3+ nodes, and tumor size >2 cm were associated with higher odds of Oncotype DX testing. Among patients having Oncotype DX testing, node status and Oncotype DX scores were significantly associated with chemotherapy receipt.Conclusion.Our criteria for reflex Oncotype DX ordering appropriately targeted patients for whom Oncotype DX would typically be ordered by providers. No significant change in the rate of Oncotype DX ordering or chemotherapy use was observed after reflex testing implementation.Implications for Practice.This study demonstrates that implementing multidisciplinary consensus reflex criteria for Oncotype DX ordering maintains a stable Oncotype DX ordering rate and chemotherapy rate, mirroring what was observed in a specific clinical practice, while decreasing treatment delays due to additional testing. These reflex criteria appropriately capture patients who would likely have had Oncotype DX ordered by their providers and for whom the test results are predicted to influence management. This intervention serves as a potential model for other large integrated, multidisciplinary oncology centers to institute processes targeting patient populations most likely to benefit from genomic assay testing, while mitigating treatment delays.

https://ift.tt/2Oa4z8t

Interferon‐α Is Effective for Treatment of Minimal Residual Disease in Patients with t(8;21) Acute Myeloid Leukemia After Allogeneic Hematopoietic Stem Cell Transplantation: Results of a Prospective Registry Study

AbstractBackground.RUNX1‐RUNX1T1 transcript levels were established as a powerful marker for predicting relapse in patients with t(8;21) acute myeloid leukemia (AML). We aimed to identify the efficacy of minimal residual disease (MRD)‐directed interferon‐alpha (IFN‐α) treatment in patients with t(8;21) AML who were positive for MRD after allogeneic hematopoietic stem cell transplantation (allo‐HSCT; n=42).Subjects, Materials, and Methods.MRD‐positive status was defined as a <4.5‐log reduction from diagnosis in RUNX1‐RUNX1T1 transcripts and/or the loss of a ≥4.5‐log reduction after 3 months after HSCT. Patients with positive MRD received six cycles of IFN‐α treatment (twice or thrice weekly of every 4 weeks cycle).Results.The 1‐year cumulative incidence of severe acute and chronic graft‐versus‐host disease after MRD‐directed IFN‐α treatment was 7.1% and 4.8%, respectively. After the treatment, 15 (35.7%), 5 (11.9%), 3 (7.1%), and 9 (21.5%) patients achieved MRD negativity at 1, 2, 3, and >3 months, respectively. Three patients relapsed after the IFN‐α treatment, in which the 1‐year cumulative incidence of relapse was 7.2%. One patient died of severe infection at 460 days after treatment. The 1‐year probabilities of event‐free survival, disease‐free survival, and overall survival after treatment were 76.0%, 92.4%, and 92.5%, respectively. The clinical outcomes in patients who received MRD‐directed IFN‐α treatment were significantly better than those of the MRD‐positive patients without any interventions in the historical cohort.Conclusion.MRD‐directed IFN‐α treatment is effective for patients with t(8;21) AML who were MRD‐positive after allo‐HSCT. The study was registered at https://ift.tt/KkipBP as NCT02027064.Implications for Practice.In patients with t(8;21) acute myeloid leukemia (AML), the presence of post‐allogeneic hematopoietic stem cell transplantation (allo‐HSCT) minimal residual disease (MRD), measured by RUNX1‐RUNX1T1 transcript levels, has been established as a powerful marker for predicting relapse. Interferon‐alpha (IFN‐α) could exert a relatively strong graft‐versus‐leukemia effect, and MRD‐directed IFN‐α treatment is effective for patients with t(8;21) AML who were MRD‐positive after allo‐HSCT.

https://ift.tt/2naXOaM

Non‐Small Cell Lung Cancer in Countries of Central and Southeastern Europe: Diagnostic Procedures and Treatment Reimbursement Surveyed by the Central European Cooperative Oncology Group

AbstractThis article analyzes the availability of different diagnostic procedures of non‐small cell lung cancer (NSCLC) and the reimbursement landscape of drugs for NSCLC in countries of central and southeastern Europe (CEE). A survey was conducted by the Central European Cooperative Oncology Group. Results of the survey show that both availability and reimbursement of diagnoses of molecular alterations in NSCLC, the detection of which is essential for therapeutic decisions, varies widely between countries of CEE. Not only is "reflex" testing often substituted by analyses performed only "on demand," but reimbursement of such assessments varies widely between unavailability and payments by the health care system or even pharmaceutical companies. It was concluded that a structured access to testing and reimbursement should be the aim in order to provide patients with appropriate therapeutic options.Implications for Practice.This article provides an overview of the limitations in lung cancer treatment in countries of central and southeastern Europe, as well as the reimbursement status of various lung cancer treatment regimens in these countries, which directly impacts treatment options.

https://ift.tt/2nfSbIN

NGR‐hTNF and Doxorubicin as Second‐Line Treatment of Patients with Small Cell Lung Cancer

AbstractBackground.Relapsed small cell lung cancer (SCLC) patients have limited treatment options and poor outcomes. NGR‐hTNF is a vascular‐targeting agent, which increases intratumoral chemotherapy penetration and T‐lymphocyte infiltration.Methods.Twenty‐eight patients relapsing after at least one platinum‐based regimen with a treatment‐free interval shorter (n = 16; platinum‐resistant) or longer (n = 12; platinum‐sensitive) than 3 months received NGR‐hTNF 0.8 μg/m2 plus doxorubicin 75 mg/m2 every 3 weeks. The primary endpoint of this single‐arm phase II trial was progression‐free survival (PFS), and safety, response rate, and survival were secondary endpoints.Results.The most common grade 3–4 toxicities were neutropenia (53%) and anemia (21%). Median PFS was 3.2 months for all patients, 2.7 months for platinum‐resistant patients, and 4.1 months for platinum‐sensitive patients. Seven patients had partial responses (25%), including four (25%) with platinum‐resistant and three (25%) with platinum‐sensitive relapse. Mean changes from baseline in tumor burden (after two, four, and six cycles) did not differ between platinum‐resistant (−9%, −29%, and −32%) and platinum‐sensitive (−11%, −20%, and −43%) cohorts. Overall survival was associated only with baseline lymphocyte counts, with median survival times of 13.1 and 5.2 months for lymphocyte counts above or below the median, respectively.Conclusion.NGR‐hTNF plus doxorubicin showed manageable toxicity and promising activity in patients with relapsed SCLC.

https://ift.tt/2Odg92L

Serum Myostatin is Upregulated in Obesity and Correlates with Insulin Resistance in Humans

Exp Clin Endocrinol Diabetes
DOI: 10.1055/a-0641-5546

Obesity and type 2 diabetes mellitus have reached an epidemic level, thus novel treatment concepts need to be identified. Myostatin, a myokine known for restraining skeletal muscle growth, has been associated with the development of insulin resistance and type 2 diabetes mellitus. Yet, little is known about the regulation of myostatin in human obesity and insulin resistance. We aimed to investigate the regulation of myostatin in obesity and uncover potential associations between myostatin, metabolic markers and insulin resistance/sensitivity indices. Circulating active myostatin concentration was measured in the serum of twenty-eight severely obese non-diabetic patients compared to a sex and age matched lean and overweight control group (n=22). Insulin resistance/sensitivity was assessed in the obese group. Skeletal muscle and adipose tissue specimens from the obese group were collected during elective bariatric surgery. Adipose tissue samples from lean and overweight subjects were collected during elective abdominal surgery. Myostatin concentration was increased in obese compared to lean individuals, while myostatin adipose tissue expression did not differ. Muscle myostatin gene expression strongly correlated with expression of metabolic genes such as IRS1, PGC1α, SREBF1. Circulating myostatin concentration correlated positively with insulin resistance indices and negatively with insulin sensitivity indices. The best correlation was obtained for the oral glucose insulin sensitivity index. Our results point to an interesting correlation between myostatin and insulin resistance/sensitivity in humans, and emphasize its need for further evaluation as a pharmacological target in the prevention and treatment of obesity-associated metabolic complications.
[...]

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
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https://ift.tt/2O8XtRC

Subcutaneous Administration of Insulin is Associated With Regional Differences in Injection Depot Variability and Kinetics in The Rat

Exp Clin Endocrinol Diabetes
DOI: 10.1055/a-0658-1089

Background In humans, subcutaneous administration of insulin in the abdominal region or arm is associated with a faster absorption compared to the thigh or buttocks. We hypothesised that this is partly caused by differences in injection depot structure and kinetics and that the variability in insulin exposure differs between injection sites. Material and methods Regional effects on insulin pharmacokinetics were evaluated in a series of studies in Sprague Dawley rats dosed subcutaneously with insulin aspart in the neck or flank. Injection depots were visualised using µCT after subcutaneous dosing with insulin aspart mixed with the contrast agent iomeprol, and insulin exposure was determined between the scans by Luminescent Oxygen Channeling Immunoassay. Results Insulin absorption was significantly delayed by subcutaneous dosing in the flank compared to the neck region (p<0.01 or less). This delay was associated with smaller depots, as measured by reduced depot volume and surface area (p<0.001). Furthermore, the delayed absorption correlated with a slower depot disappearance (p<0.001). Regional differences in depot variability were not reflected by similar differences in pharmacokinetic variability. Conclusion Structure and kinetics of subcutaneous injection depots—as detected by µCT scans—predict insulin exposure and may thus contribute to the regional differences in insulin pharmacokinetics. The present methodology is applicable for visualisation of insulin injection depots in vivo. Our results did however not support a link between the variability in depot size and insulin pharmacokinetics.
[...]

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

https://ift.tt/2M0yuT2

Positive Effects of Practical Nutrition Lessons in a Primary School Setting with a High Proportion of Migrant School Children

Exp Clin Endocrinol Diabetes
DOI: 10.1055/a-0661-1919

Background Children with migration background are at increased risk for overweight, partly due to less favorable dietary habits compared to their German counterparts. We examined the effects of practical nutrition lessons among children with a high proportion of migration background in a primary school setting. Methods Ten 3rd and 4th grade classes (n=166 children, 73% with migration background) received the intervention and nine school classes (n=139 children, 76% with migration background) served as control. Before, shortly after (only among the intervention group) and three months after the three-day practical nutrition lessons, the nutrition-related skills, behavior, attitudes, and knowledge of the children were assessed using a questionnaire. Changes between baseline and 1st follow-up among children of the intervention group were calculated using linear mixed models. Differences between the two groups for changes between baseline and 2nd follow-up were tested using linear regression analyses. Models were adjusted for potential confounders. Results Shortly after the practical nutrition lessons, the children of the intervention group had improved their knowledge (β=1.7; 95% CI: 1.0; 2.4, P<0.001) and skills (β=1.8; 95% CI: 1.4; 2.2, P<0.001). These changes were sustainable and larger in the intervention compared to the control group (knowledge: β=1.6; 95% CI: 0.7; 2.5, P<0.001; skills: β=1.3; 95% CI: 0.7; 1.9, P<0.001). Changes in nutrition-related behavior and attitudes did not differ between the groups. Conclusions Providing practical nutrition lessons in a primary school setting with a high proportion of children with immigrational background improved the children's nutrition-related knowledge and skills.
[...]

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

https://ift.tt/2MjZ8n0

Linking Sleep Disturbance To Idiopathic Male Infertility

Recently published data suggests that male fertility has declined over the past four decades. The reasons for the decline are unclear with up to 50% of cases of male infertility remaining unexplained (idiopathic male infertility). Whilst environmental factors and rising rates of obesity have been implicated, there is now growing evidence that sleep disturbance may be an independent causative factor. Indeed, the prevalence of sleep disturbance appears to be increasing in parallel with deterioration in population sperm quality, a commonly used surrogate marker of male fertility.

https://ift.tt/2M2lk7W

Climate Change and Sleep: A Systematic Review of the Literature and Conceptual Framework

From disaster related stress causing insomnia, to poor air quality causing sleep related breathing problems, climate change poses a potentially serious threat to human sleep. We conducted a systematic review evaluating the relationship between climate change and human sleep in the PubMed, Scopus, and Cochrane databases from 1980 through 2017 following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Inclusion criteria included epidemiologic studies published in English that reported observational population data on human sleep and its relationship to climate change, temperature, extreme weather events and climate related disasters (e.g.

https://ift.tt/2Meb3CC

Targeting volume overload and overnight rostral fluid shift: a new perspective to treat sleep apnea

Sleep apnea is a common condition associated with increased morbidity and mortality. Continuous positive airway pressure and oral appliances are efficient for treating sleep apnea; however, they are often poorly tolerated. Therefore, alternative therapies are needed. Overnight rostral fluid shift has been implicated in the pathogenesis of sleep apnea, particularly in conditions associated with fluid overload. Fluid shift predisposes to both obstructive and central sleep apnea, with the type of sleep apnea being related to whether the fluid shifts from the legs into the neck or chest, respectively.

https://ift.tt/2M2q8u6

Cross-section investigation and analysis of anxiety and depression in preoperative patients in outpatient department of aesthetic plastic surgery in a general hospital in China

Objective: This study was designed to evaluate the anxiety and depression disorders and investigate the prevalence and risk factors in preoperative patients who came to cosmetic plastic surgery clinic. Methods: Using the field survey method, the estimate of anxiety and depression in preoperative patients was made by the Hospital Anxiety and Depression Scale from July 2016 to July 2017 in the outpatient department of plastic surgery in a general hospital. The demographic information was collected.

https://ift.tt/2LXrCpr

Reconstruction of columellar defects: which surgical technique to choose ? A retrospective study of 18 patients

The reconstruction of the columella is challenging and poorly evaluated in the literature. Our study aimed to evaluate retrospectively the different techniques used in our center and to propose an algorithm of reconstruction adapted to each patient. We report a retrospective cohort study included 18 patients (9 men and 9 women; 53 years-old in average) with columellar reconstruction treated from 1999 through 2014. Six different techniques were used: chondrocutaneous graft, nasolabial flap, paramedian forehead flap and scalping flap according to the Converse technique or the Raulo technique.

https://ift.tt/2Mj55jQ

Nipple-sparing mastectomy with different approaches: surgical incisions, complications and cosmetic results. Preliminary results of 100 consecutive patients at a single center

Nipple areola sparing mastectomy is a novel surgical approach that preserves the nipple areola complex. Patients with moderate and/or severe breast ptosis are usually not eligible for this surgical approach. In this study we are aimed to demonstrate the feasibility of non-conventional surgical approaches for nipple sparing mastectomy.One hundred consecutive patients were enrolled for this study, with diagnosed primary breast cancer. Clinical and pathological data, such as body mass index, smoking status, breast ptosis, complications and aesthetic satisfaction (Breast-Q test) were considered.

https://ift.tt/2vhV3cl

Sensory and functional morbidity following sural nerve harvest in paediatric patients

The sural nerve is a common donor site for nerve reconstruction. The only study describing outcomes in paediatric patients was following bilateral sural nerve harvest prior to the age of one. Bilateral nerve harvest at such a young age may limit patients' ability to perceive a sensory difference. The objective of this study was to understand the sensory and functional deficit after unilateral sural nerve harvest in paediatric patients.

https://ift.tt/2O8CKNO

Negative-Pressure Wound Therapy: An Effective Adjunctive Treatment to Assist Flap Survival and Wound Closure

Dear Sir,

https://ift.tt/2vhUWgV

The impact of orthognathic surgery on velopharyngeal function by evaluating speech and cephalometric radiographs

: Maxillary retrognathia is a well-known consequence of abnormal facial growth in patients with cleft lip and palate. Orthognathic surgery improves facial appearance and occlusion, but may induce velopharyngeal insufficiency. The aim of the study was to evaluate the effect of orthognathic surgery on velopharyngeal function using speech analysis and lateral cephalometric radiographs.

https://ift.tt/2O5VihF

Autologous fat grafting for enhancement of breast reconstruction with a transverse myocutaneous gracilis flap: A cohort study

The transverse myocutaneous gracilis (TMG) flap is a viable option for reconstruction of small to moderate breasts. The purpose of this series was to examine outcomes of fat grafting to breast and donor site secondary to breast reconstruction with a TMG flap.

https://ift.tt/2LXrfLz

Post oncological lacrimal duct reconstruction; a practical classification system for reconstructive planning and short-term results of a case series.

: Surgical resection of skin tumors in the medial canthal area may damage the lacrimal duct and can result in chronic ephiphora. Post oncologic reconstruction of the lacrimal duct has not been studied extensively. The current study discusses the anatomical and functional features of the lacrimal duct. It describes short-term functional outcomes after monocanalicular reconstruction of the lacrimal duct in a case series of 10 patients.

https://ift.tt/2O8Cmik

Scholar : Experimental and Therapeutic Medicine - Volume:16 Number:3

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TABLE OF CONTENTS September-2018 Volume 16 Issue 3

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Advances in CLARITY‑based tissue clearing and imaging (Review) Hao Du, Peihong Hou, Wenbo Zhang, Qiyu Li View Abstract ❯
Fluorescent contrast agents for tumor surgery (Review) Qi Xiao, Tianming Chen, Shilin Chen View Abstract ❯
Combined antitumor effects of P‑5m octapeptide and 5‑fluorouracil on a murine model of H22 hepatoma ascites Xiao Han, Liping An, Dongmei Yan, Matsuura Hiroshi, Weiguang Ding, Mengchuan Zhang, Guangyu Xu, Ying Sun, Guangxin Yuan, Manli Wang, Nanxi Zhao, Jingbo Sun, Xun Zhu, Peige Du View Abstract ❯
Use of ozonated water as a new therapeutic approach to solve current concerns around antitumor treatment Kohei Kuroda, Masamiti Yamashita, Yusuke Murahata, Kazuo Azuma, Tomohiro Osaki, Takeshi Tsuka, Norihiko Ito, Tomohiro Imagawa, Yoshiharu Okamoto View Abstract ❯
Efficacy, functional outcome and post‑operative complications of total abdominal colectomy with ileorectal anastomosis vs. segmental colectomy in hereditary non‑polyposis colorectal cancer Jie Sun, Mingjie Dong, Xiaoping Xiao View Abstract ❯
Microarray data analysis to identify differentially expressed genes and biological pathways associated with asthma Shanshan Qi, Guanghui Liu, Xiang Dong, Nan Huang, Wenjing Li, Hao Chen View Abstract ❯
HOXD10 silencing suppresses human fibroblast‑like synoviocyte migration in rheumatoid arthritis via downregulation of the p38/JNK pathway Luan Luan, Yingying Ma, Lihua Zhang View Abstract ❯
MicroRNA‑138 inhibits SOX12 expression and the proliferation, invasion and migration of ovarian cancer cells Miaomiao Qu, Yongning Zhu, Meng Jin View Abstract ❯
Preparation and characterization of norcantharidin liposomes modified with stearyl glycyrrhetinate Jing Zhu, Wei Zhang, Dandan Wang, Suzhen Li, Wei Wu View Abstract ❯
Effect of naproxen on proliferation and differentiation of primary cell cultures isolated from human cartilage tissue Numan Karaarslan, Ahmet Guray Batmaz, Ibrahim Yilmaz, Hanefi Ozbek, Tezcan Caliskan, Duygu Yasar Sirin, Necati Kaplan, Kadir Oznam, Ozkan Ates View Abstract ❯
Combination therapy with BMP‑2 and psoralen enhances fracture healing in ovariectomized mice Kui Huang, Guofeng Wu, Ji Zou, Songming Peng View Abstract ❯
MicroRNA‑101‑3p inhibits proliferation in retinoblastoma cells by targeting EZH2 and HDAC9 Qifang Jin, Wenfeng He, Leifeng Chen, Yang Yang, Ke Shi, Zhipeng You View Abstract ❯
Role of ALK5/SMAD2/3 signaling in the regulation of NOX expression in cerebral ischemia/reperfusion injury Zheng Lou, Ai‑Ping Wang, Xiao‑Ming Duan, Guo‑Huang Hu, Mei‑Ling Zuo, Zhong‑Bao Yang View Abstract ❯
Relationship between serum levels of miR-204 and clinical features of patients with lumbar disc herniation - an analysis based on 1,589 cases Jun Peng, Yingjie Liu, Yang Zong, Yulin Zhan View Abstract ❯
Estrogen relaxes gastric muscle cells via a nitric oxide‑ and cyclic guanosine monophosphate‑dependent mechanism: A sex‑associated differential effect Othman A. Al‑Shboul, Mona S. Nazzal, Ayman G. Mustafa, Ahmed N. Al‑Dwairi, Mohammad A. Alqudah, Amal Abu Omar, Mahmoud A. Alfaqih, Mohammad I. Alsalem View Abstract ❯
Decreased expression of microRNA‑214 contributes to imatinib mesylate resistance of chronic myeloid leukemia patients by upregulating ABCB1 gene expression Jing Jin, Jia Yao, Fang Yue, Zhaoying Jin, Dan Li, Shan Wang View Abstract ❯
Expression of miR‑376 in blood of pregnant women with preeclampsia and its effect on 25‑hydroxyvitamin D Jinlan Li, Jiangdong Du, Zhan Wang, Chenghong Wang, Jianhua Bai, Su Zhang View Abstract ❯
Identification of miRNAs associated with the mechanical response of hepatic stellate cells by miRNA microarray analysis Suhong Yi, Xia Qin, Xu Luo, Yi Zhang, Zhijun Liu, Liang Zhu View Abstract ❯
Bletilla striata polysaccharide has a protective effect on intestinal epithelial barrier disruption in TAA‑induced cirrhotic rats Lei Luo, Zhang Zhou, Juan Xue, Yao Wang, Juan Zhang, Xin Cai, Yuqing Liu, Fan Yang View Abstract ❯
Flexible ureteroscopic holmium laser lithotripsy with PolyScope for senile patients with renal calculi Ke Xu, Jie Ding, Bowen Shi, Yanyuan Wu, Yunteng Huang View Abstract ❯
Effects of transplanted adipose derived stem cells on the expressions of α‑SMA and DCN in fibroblasts of hypertrophic scar tissues in rabbit ears Haihan Chu, Yunpeng Wang, Xiuchun Wang, Xianhui Song, Huaqing Liu, Xue Li View Abstract ❯
Histopathological changes and onset of severe hepatic steatosis in rats fed a choline‑free diet Theodore Karatzas, Nikolaos Sikalias, Dimitrios Mantas, Apostolos Papalois, Konstantinos Alexiou, Lamprini Mountzalia, Gregory Kouraklis View Abstract ❯
Effects of different doses of dexmedetomidine on analgesic efficacy and inflammatory cytokines in patients undergoing laparoscopic surgery Zhigang Wan, Jie Wang, Hui Cao, Lili Wu View Abstract ❯
Lund exhaust on hemodynamic parameters and inflammatory mediators in patients undergoing cardiac valve replacement under cardiopulmonary bypass Jihong Zhu, Weimin Zhang, Guoying Shen, Xin Yu, Jige Guo, Taidi Zhong View Abstract ❯
Early ultrasound-guided percutaneous catheter drainage in the treatment of severe acute pancreatitis with acute fluid accumulation Huazhi Li, Yongzhe Wu, Chen Xu, Hongchao An, Chunhai Guo, Hongli Cui View Abstract ❯
Gambogic acid regulates the migration and invasion of colorectal cancer via microRNA‑21‑mediated activation of phosphatase and tensin homolog Guangyi Gao, Yinzhu Bian, Hanqing Qian, Mi Yang, Jing Hu, Li Li, Lixia Yu, Baorui Liu, Xiaoping Qian View Abstract ❯
Serum anion gap on admission predicts intensive care unit mortality in patients with aortic aneurysm Qinchang Chen, Qingui Chen, Lingling Li, Xixia Lin, Shih‑I Chang, Yonghui Li, Zhenluan Tian, Wei Liu, Kai Huang View Abstract ❯
Effects of dexmedetomidine hydrochloride on hemodynamics, postoperative analgesia and cognition in cesarean section Dehua Kong, Jianhua Bai, Suqiao Ma, Cong Li, Lina Yang, Xiangang Kong View Abstract ❯
Therapeutic effect of MIPPSO in the thoracolumbar vertebra fracture Kewei Ren, Jilei Tang, Xuefeng Jiang, Luming Nong, Yanqing Gu View Abstract ❯
A meta‑analysis on anterior cruciate ligament reconstruction: Is modified transtibial technique inferior to independent drilling techniques? Qunhu Zhang, Yu Kou, Zhen Yuan View Abstract ❯
Pirfenidone suppresses bleomycin‑induced pulmonary fibrosis and periostin expression in rats Xiaoxia Song, Wencheng Yu, Fang Guo View Abstract ❯
Dynamic expression of matrix metalloproteinases 2, 9 and 13 in ovariectomy‑induced osteoporosis rats Xuefeng Zheng, Yuanyuan Zhang, Shiming Guo, Wenming Zhang, Jinyun Wang, Yanping Lin View Abstract ❯
Downregulation of microRNA‑1 attenuates glucose‑induced apoptosis by regulating the liver X receptor α in cardiomyocytes Yongxia Cheng, Wei Zhao, Xiaodong Zhang, Lixin Sun, Heran Yang, Ying Wang, Yong Cao, Yanhui Chu, Guibo Liu View Abstract ❯
Fmr1 protects cardiomyocytes against lipopolysaccharide‑induced myocardial injury Jiasheng Bao, Chen Ye, Zhelan Zheng, Zhengwen Zhou View Abstract ❯
Lycium barbarum polysaccharides attenuates the apoptosis of hippocampal neurons induced by sevoflurane Yuhai Xie, Xuejun Wang View Abstract ❯
Integrated analysis of key mRNAs and lncRNAs in osteoarthritis Lei Chen, Yingqi Zhang, Zhitao Rao, Jincheng Zhang, Yeqing Sun View Abstract ❯
Identification of key pathways and biomarkers in sorafenib‑resistant hepatocellular carcinoma using bioinformatics analysis Danping Huang, Weiqu Yuan, Hanmin Li, Shaodong Li, Zuanguang Chen, Hongzhi Yang View Abstract ❯
Efficacy and safety of febuxostat for treating hyperuricemia in patients with chronic kidney disease and in renal transplant recipients: A systematic review and meta‑analysis Xuzhong Liu, Kun Liu, Qing Sun, Yunyan Wang, Junsong Meng, Zongyuan Xu, Zhaofei Shi View Abstract ❯
Triiodothyronine alleviates alcoholic liver disease injury through the negative regulation of the NLRP3 signaling pathway Xiang Dong, Hongmei Yang, Cong Li, Qi Liu, Qinglin Bai, Zhaoran Zhang View Abstract ❯
A combined study of 18F‑FDG PET‑CT and fMRI for assessing resting cerebral function in patients with major depressive disorder Chang Fu, Hongju Zhang, Ang Xuan, Yongju Gao, Junling Xu, Dapeng Shi View Abstract ❯
Efficacy and safety of mycophenolate mofetil for IgA nephropathy: An updated meta‑analysis of randomized controlled trials Jian‑Nan Zheng, Tong‑Dan Bi, Lin‑Bo Zhu, Lin‑Lin Liu View Abstract ❯
Effect of silencing lncRNATUG1 on rapamycin‑induced inhibition of endothelial cell proliferation and migration Xue Gao, Tao Zhang, Xi‑Yun Zeng, Guo‑Jian Li, Ling‑Juan Du, Zhen‑Huan Ma, Jia Wan, Yong Yang View Abstract ❯
Association between GDF5 single nucleotide polymorphism rs143383 and lumbar disc degeneration Zhen Wang, Yuqian Li, Yunhao Wang, Xiaodong Wang, Jianhua Zhang, Jiwei Tian View Abstract ❯
Association of miR-182 expression in amniotic fluid with intrauterine infection and brain injury in premature infants Fengchun Gao, Xiaojuan Jiang, Qirong Li, Kefeng Fan View Abstract ❯
Preserving hepatic artery flow during portal triad blood occlusion improves regeneration of the remnant liver in rats with obstructive jaundice following partial hepatectomy Zhe Kong, Jian‑Jun Hu, Xin‑Lan Ge, Ke Pan, Chong‑Hui Li, Jia‑Hong Dong View Abstract ❯
Effects of imipenem combined with low‑dose cyclophosphamide on the intestinal barrier in septic rats Peng Guo, Shun‑Wen Zhang, Jie Zhang, Jiang‑Tao Dong, Jiang‑Dong Wu, Su‑Tu Tang, Jun‑Ting Yang, Wan‑Jiang Zhang, Fang Wu View Abstract ❯
Intra‑articular, single‑shot co‑injection of hyaluronic acid and corticosteroids in knee osteoarthritis: A randomized controlled trial Shan‑Zheng Wang, Dong‑Ying Wu, Qing Chang, Yu‑Dong Guo, Chen Wang, Wei‑Min Fan View Abstract ❯
MicroRNA‑144 mediates chronic inflammation and tumorigenesis in colorectal cancer progression via regulating C‑X‑C motif chemokine ligand 11 Bin Han, Dan Feng, Xin Yu, Yuanqi Liu, Ming Yang, Fei Luo, Liming Zhou, Fu Liu View Abstract ❯
Ultrasound‑guided continuous fascia iliaca compartment block for pre‑operative pain control in very elderly patients with hip fracture: A randomized controlled trial Yanhui Ma, Jie Wu, Jixiu Xue, Fei Lan, Tianlong Wang View Abstract ❯
Effects of comprehensive pulmonary rehabilitation therapy on pulmonary functions and blood gas indexes of patients with severe pneumonia Wei Liu, Xuri Mu, Xin Wang, Peipei Zhang, Li Zhao, Qiuju Li View Abstract ❯
Expression and significance of autophagy genes LC3, Beclin1 and MMP-2 in endometriosis Xiaoyu Sui, Yadong Li, Yurong Sun, Chunyan Li, Xiulan Li, Guiyu Zhang View Abstract ❯
Reduced hepcidin level features osteoporosis Bin Liu, Caihua Liu, Weifeng Zhong, Min Song, Shouqin Du, Jianli Su View Abstract ❯
Baicalin and puerarin reverse epithelial‑mesenchymal transition via the TGF‑β1/Smad3 pathway in vitro Tao Wu, Tao Liu, Lianjun Xing, Guang Ji View Abstract ❯
The role of Wnt signaling pathway in atherosclerosis and its relationship with angiogenesis Jingru Du, Junfeng Li View Abstract ❯
Correlation between the expression of inflammatory cytokines IL-6, TNF-α and hs-CRP and unfavorable fetal outcomes in patients with pregnancy-induced hypertension Dehua Kong, Hui Wang, Yan Liu, Hongjun Li, Hongyan Wang, Peng Zhu View Abstract ❯
Nerve growth factor and substance P may be involved in moist exposed burn ointment‑mediated chronic refractory wound healing Huang‑De Fu, Shu Wang, Bin Ge, Li‑Qing Li, Hong‑Meng Zeng, Qing‑Feng Shu, Yang Zhou View Abstract ❯
Hybrid surgery for an arteriovenous malformation fed by an accessory middle cerebral artery and drained by a developmental venous anomaly: A case report and literature review Kailing Li, Yunbao Guo, Limei Qu, Baofeng Xu, Kan Xu, Jinlu Yu View Abstract ❯
H1N1 influenza virus epitopes classified by monoclonal antibodies Chunyan Guo, Haixiang Zhang, Xin Xie, Yang Liu, Lijun Sun, Huijin Li, Pengbo Yu, Hanyu Hu, Jingying Sun, Yuan Li, Qing Feng, Xiangrong Zhao, Daoyan Liang, Zhen Wang, Jun Hu View Abstract ❯
Therapeutic effect of berberine on renal ischemia-reperfusion injury in rats and its effect on Bax and Bcl-2 Haiya Zheng, Jun Lan, Jinmei Li, Leili Lv View Abstract ❯
Effect of JAK2/STAT3 signaling pathway on liver injury associated with severe acute pancreatitis in rats Minli Li, Xiaohua Zhang, Bin Wang, Xiaobing Xu, Xiaowei Wu, Meixia Guo, Fangyu Wang View Abstract ❯
The relationship between insulin resistance, adiponectin and C-reactive protein and vascular endothelial injury in diabetic patients with coronary heart disease Weihua Xu, Minghui Tian, Yanju Zhou View Abstract ❯
Chronic pulmonary complications associated with toxic epidermal necrolysis: A case report and literature review Nuo Xu, Xuehua Chen, Shengdi Wu, Maosong Ye, Meiling Zhang, Lin Tong, Xiaodan Zhu, Jie Liu, Feifei Hu, Chunxue Bai View Abstract ❯
The biological effect and mechanism of the Wnt/β‑catenin signaling pathway on malignant melanoma A375 cells Yuxia Lin, Fangfei Wang, Qingfei Xing, Feng Guo, Mengzhen Wang, Yunjie Li View Abstract ❯
MicroRNA‑21 promotes the proliferation, migration and invasion of non‑small cell lung cancer A549 cells by regulating autophagy activity via AMPK/ULK1 signaling pathway Shuping Li, Xiaofei Zeng, Ruidong Ma, Li Wang View Abstract ❯
Improved heart failure by Rhein lysinate is associated with p38MAPK pathway Wei Wang, Xin Meng, Jing Wang, Yong Li View Abstract ❯
Impact of weight cycling on CTRP3 expression, adipose tissue inflammation and insulin sensitivity in C57BL/6J mice Xin Li, Li Jiang, Miao Yang, Yu‑Wen Wu, Jia‑Zhong Sun View Abstract ❯
Hemophagocytic lymphohistiocytosis presenting with annular erythema multiforme‑like eruptions in a patient with angioimmunoblastic T cell lymphoma: A case report Liping Zhang, Chunguang Tong, Yaqi Tan, Shiguang Peng, Yanling He, Tianyou Wang View Abstract ❯
Ultrasonic evaluation of congenital vaginal oblique septum syndrome: A study of 21 cases Yong‑Hao Gai, Hui‑Li Fan, Ye Yan, Shi‑Feng Cai, Yue‑Zhong Zhang, Ru‑Xin Song, Shu‑Liang Song View Abstract ❯
Specific matrix metalloproteinases and calcification factors are associated with the vulnerability of human carotid plaque Zhou‑Ying Guo, Bai Zhang, Yan‑Hong Yan, Shang‑Shang Gao, Jing‑Jing Liu, Lan Xu, Pin‑Jing Hui View Abstract ❯
Knockdown of BACE1‑AS by siRNA improves memory and learning behaviors in Alzheimer's disease animal model Wenting Zhang, Hao Zhao, Qian Wu, Wenan Xu, Minwu Xia View Abstract ❯
Computerized tomography features and clinicopathological analysis of Kimura disease in head and neck Li Zhang, Li Yao, Wei‑Wei Zhou, Jian‑Nan Ma, Chun‑Qian Zhang View Abstract ❯
Combination of catheter ablation for non‑valvular atrial fibrillation and left atrial appendage occlusion in a single procedure Xuexun Li, Jianping Li, Hongxia Chu, Lihong Wang, Lei Shi, Guangqiang Wang, Xiaofei Wang View Abstract ❯
Wnt3a‑regulated TCF4/β‑catenin complex directly activates the key Hedgehog signalling genes Smo and Gli1 Youpei Wang, Peipei Lin, Qing Wang, Meiqin Zheng, Lingxia Pang View Abstract ❯
Preliminary study on the effect of brazilin on biofilms of Staphylococcus aureus Dan Peng, Anlin Chen, Bin Shi, Xun Min, Tao Zhang, Zheling Dong, Huan Yang, Xianlian Chen, Yingbiao Tian, Zehui Chen View Abstract ❯
Clinical therapy of hyaluronic acid combined with platelet‑rich plasma for the treatment of knee osteoarthritis Wenxing Yu, Peng Xu, Guiling Huang, Lin Liu View Abstract ❯
Inflammatory cytokine expression in patients with sepsis at an intensive care unit Lili Wang, Hongyan Zhao, Dongxu Wang View Abstract ❯
The 4‑hydroxynonenal mediated oxidative damage of blood proteins and lipids involves secondary lipid peroxidation reactions Ayman G. Mustafa, Mahmoud A. Alfaqih, Othman Al‑Shboul View Abstract ❯
Andrographolide attenuates viral myocarditis through interactions with the IL‑10/STAT3 and P13K/AKT/NF‑κβ signaling pathways Yaxin Zhao, Meng Wang, Yang Li, Wanting Dong View Abstract ❯
Transanal endorectal stepwise gradient muscular cuff cutting pull‑through method: Technique refinements and comparison with laparoscopy‑assisted procedures Zebing Zheng, Fan Zhang, Zhu Jin, Mingjuan Gao, Yuchen Mao, Yan Qu, Yuanmei Liu View Abstract ❯
Reversible splenial lesion syndrome associated with acute Mycoplasma pneumoniae‑associated encephalitis: A report of four cases and literature review Xiaoyu Dong, Shuyan Cong View Abstract ❯
Antitumor effect of recombinant Mycobacterium smegmatis expressing MAGEA3 and SSX2 fusion proteins Wen Jian, Xin Li, Jian Kang, Yingfeng Lei, Yinlan Bai, Ying Xue View Abstract ❯
[Erratum] Tanshinone IIA and Astragaloside IV promote the angiogenesis of mesenchymal stem cell‑derived endothelial cell‑like cells via upregulation of Cx37, Cx40 and Cx43 Zhe Li, Sha Zhang, Liang Cao, Wei Li, Yu‑Chen Ye, Zi‑Xuan Shi, Zong‑Ren Wang, Lian‑Xu Sun, Jia‑Wei Wang, Lin‑Tao Jia, Wen Wang View Abstract ❯
[Corrigendum] Protective effect of astragalosides from Radix Astragali on adriamycin-induced podocyte injury Yi‑Pa Sai, Yuan‑Chun Sun, Xing‑Xing Chen, Xuan Luo, Jing Liu, Wei‑Jing Cui View Abstract ❯
Cycloastragenol: An exciting novel candidate for age‑associated diseases (Review) Yongjie Yu, Limin Zhou, Yajun Yang, Yuyu Liu View Abstract ❯
Novel treatment strategies for patients with HER2‑positive breast cancer who do not benefit from current targeted therapy drugs (Review) Nan Jiang, Jing‑Jing Lin, Jun Wang, Bei‑Ning Zhang, Ao Li, Zheng‑Yang Chen, Song Guo, Bin‑Bin Li, Yu‑Zhong Duan, Ru‑Yi Yan, Hong‑Feng Yan, Xiao‑Yan Fu, Jin‑Lian Zhou, He‑Ming Yang, Yan Cui View Abstract ❯
Effect of hyperbaric oxygenation therapy on post‑concussion syndrome (Review) Yang Dong, Xia Hua Hu, Tao Wu, Tong Wang View Abstract ❯
Applications and development of permeability imaging in ischemic stroke (Review) Hui Chen, Guangming Zhu, Nan Liu, Ying Li, Yonghong Xia View Abstract ❯
In vitro study on human umbilical cord mesenchymal stem cells transfected with lentivirus‑mediated hNIS‑EGFP dual reporter gene and co‑labeled with superparamagnetic iron oxide Yu Meng, Huanhuan Liu, Ning Bian, Jian Gong, Xing Zhong, Chunrong Huang, Wenxue Liang, Hao Xu View Abstract ❯
Protective effects of primary neural stem cell treatment in ischemic stroke models Xiaowen Yu, Xiaoqing Wang, Shuxiong Zeng, Xiping Tuo View Abstract ❯
Morroniside protects against cerebral ischemia/reperfusion injury by inhibiting neuron apoptosis and MMP2/9 expression Guoyong Zeng, Weijiang Ding, Yin Li, Meiying Sun, Liying Deng View Abstract ❯
Long noncoding RNA EZR‑AS1 promotes tumor growth and metastasis by modulating Wnt/β‑catenin pathway in breast cancer Yu Bai, Xian Zhou, Luo Huang, Yue Wan, Xiaoyu Li, Ying Wang View Abstract ❯
Long non‑coding RNA NEAT1 promotes migration and invasion of oral squamous cell carcinoma cells by sponging microRNA‑365 Xiaohua Liu, Wenzhi Shang, Fuju Zheng View Abstract ❯
Free bladder mucosa graft harvested by water‑jet: A novel, minimally invasive technique for urethral reconstruction Zhixian Wang, Xiaoyong Zeng, Ruibao Chen, Tao Wang, Jia Hu, Shaogang Wang, Jihong Liu View Abstract ❯
Thromboelastography‑derived parameters for the prediction of acute thromboembolism following non‑steroidal anti‑inflammatory drug‑induced gastrointestinal bleeding: A retrospective study Tian‑Yu Chi, Ying Liu, Hong‑Ming Zhu, Mei Zhang View Abstract ❯
Hes1 negatively regulates neurogenesis in the adult mouse dentate gyrus following traumatic brain injury Rong Yan, Lin Zhang, Mengqi Li, Xiaozhi Liu, Xinyu Yang, Lei Chen View Abstract ❯
Triptolide protects podocytes via autophagy in immunoglobulin A nephropathy Shikai Liang, Juan Jin, Xiaogang Shen, Xinxin Jiang, Yiwen Li, Qiang He View Abstract ❯
Exome sequencing reveals a novel MFN2 missense mutation in a Chinese family with Charcot‑Marie‑Tooth type 2A Yi You, Xiaodong Wang, Shan Li, Xiuli Zhao, Xue Zhang View Abstract ❯
Osteogenic potential of cell spheroids composed of varying ratios of gingiva‑derived and bone marrow stem cells using concave microwells Jae‑Yong Tae, Hyuna Lee, Hyunjin Lee, Youngkyung Ko, Jun‑Beom Park View Abstract ❯
Research on the changes in balance motion behavior and learning, as well as memory abilities of rats with multiple cerebral concussion-induced chronic traumatic encephalopathy and the underlying mechanism Huan Zhang, Zhenguang Zhang, Zhen Wang, Yongjiang Zhen, Jiangyun Yu, Hai Song View Abstract ❯
Effects of glutamine on cytokines 1L‑1 and TNF‑α in rehabilitation and prognosis of patients with lobectomy Xuefeng Wang, Lei Huang, Yanxia Qu, Hongmei Lv, Xiaohua He View Abstract ❯
Effects of UV on apoptotic factors in lens epithelial cells of an animal model Juling Lv, Yiqiao Xing View Abstract ❯
Impact of G-CSF on expressions of Egr-1 and VEGF in acute ischemic cerebral injury Dian-Gui Zhou, Yang-Hong Shi, You-Qiang Cui View Abstract ❯
Mesalazine suppository for the treatment of refractory ulcerative chronic radiation proctitis Changliang Wu, Liyu Guan, Li Yao, Jiean Huang View Abstract ❯
Correlation analysis of intestinal flora with hypertension Jilun Liu, Ning An, Cong Ma, Xiaofeng Li, Jie Zhang, Wei Zhu, Yihe Zhang, Junpeng Li View Abstract ❯
Percutaneous renal artery stent implantation in the treatment of atherosclerotic renal artery stenosis Youbin Hu, Yongguang Zhang, Hua Wang, Yong Yin, Chunhua Cao, Jing Luo, Yunfei Wang View Abstract ❯
LncRNA MEG3 overexpression inhibits the development of diabetic retinopathy by regulating TGF‑β1 and VEGF Daning Zhang, Haixiang Qin, Ying Leng, Xiangjun Li, Lei Zhang, Dan Bai, Yujun Meng, Jingyi Wang View Abstract ❯
Imaging manifestations of B-mode ultrasound combined with CT in tuberculous pleuritis patients and the diagnostic value Shisheng Zhou, Jiming Zhao, Xianhui Song, Mei Zheng, Hong Li, Yinghua Pan View Abstract ❯
Cilostazol on the expression of ICAM‑1, VCAM-1and inflammatory factors in plasma in patients with thromboangiitis obliterans Fuchen Song, Bo Ji, Ting Chen View Abstract ❯
Immunomagnetic enrichment to evaluate the role of home environment specimens in transmission of enterovirus 71 Wangfeng Zhu, Xiuhui Yang, Yong Zhou, Yansheng Yan View Abstract ❯
Salidroside prevents hydroperoxide‑induced oxidative stress and apoptosis in retinal pigment epithelium cells Yan Yin, Dejie Liu, Donghua Tian View Abstract ❯
Pharmaceutical analysis of different antibiotic regimens in the treatment of lower respiratory tract infection Lin Zhang, Benhong Liu, Chunbin Wang View Abstract ❯
Effect of intraperitoneal or intracerebroventricular injection of streptozotocin on learning and memory in mice Yang Zhang, Rong Ding, Shanshan Wang, Zhiyun Ren, Lingyan Xu, Xunle Zhang, Jiahui Zhao, Yu Ding, Yu Wu, Yuesong Gong View Abstract ❯
Effect of montelukast on the expression of CD4+CD25+ regulatory T cells in children with acute bronchial asthma Xiaoting Qu, Yuan Chen, Chaoyang Yin View Abstract ❯
Immunohistochemical profile of long‑standing traumatic retinal detachment in atrophic globe in a young patient Shiliang Liu, Yuanyuan Chen, Zhen Chen, Yiqiao Xing, Yin Shen View Abstract ❯
Hypermethylation of the κ1 opioid receptor promoter in Chinese heroin and methamphetamine addicts Huihui Ji, Guili Liu, Xuting Xu, Huifen Liu, Lei Xu, Haochang Hu, Yingmin Chen, Qinxiao Hong, Qinwen Wang, Wenwen Shen, Longhui Li, Xiaohu Xie, Wenhua Zhou, Shiwei Duan View Abstract ❯
In vitro culture and biological properties of broiler adipose‑derived stem cells Tengfei Lu, Wenhua Pei, Kunfu Wang, Shuang Zhang, Fenghao Chen, Yangnan Wu, Weijun Guan View Abstract ❯
Vascularization of vessel pedicle in hypospadias and its relationship to near‑period complications Zhang Zhao, Ning Sun, Xiangming Mao View Abstract ❯
Arthroscopic partial capsulotomy for exposure and treatment of hip disease Ze Zhuang, Yuxian Chen, Kishor Chhantyal, Ronghan He, Tangzhao Liang, Dehai Shi View Abstract ❯
Serum exosomal miR‑328, miR‑575, miR‑134 and miR‑671‑5p as potential biomarkers for the diagnosis of Kawasaki disease and the prediction of therapeutic outcomes of intravenous immunoglobulin therapy Xiaofei Zhang, Guangda Xin, Dajun Sun View Abstract ❯
miRNA‑218 regulates the proliferation and apoptosis of cervical cancer cells via targeting Gli3 Jing Zhang, Shengze Li, Yanhua Li, Hongli Liu, Yuan Zhang, Qingsong Zhang View Abstract ❯
Quercetin is able to alleviate TGF‑β‑induced fibrosis in renal tubular epithelial cells by suppressing miR‑21 Yaochen Cao, Jialin Hu, Jianying Sui, Limei Jiang, Yakun Cong, Guoqing Ren View Abstract ❯
Efficacy and safety of baricitinib for active rheumatoid arthritis in patients with an inadequate response to conventional synthetic or biological disease‑modifying anti‑rheumatic drugs: A meta‑analysis of randomized controlled trials Zhi‑Peng Wu, Pei Zhang, Jian‑Zhong Bai, Yuan Liang, Jin‑Shan He, Jing‑Cheng Wang View Abstract ❯
Screening of genes associated with inflammatory responses in the endolymphatic sac reveals underlying mechanisms for autoimmune inner ear diseases Juhong Zhang, Na Wang, Anting Xu View Abstract ❯
Altered circulating T follicular helper cells in patients with chronic immune thrombocytopenia Lan Dai, Linyan He, Zhaoyue Wang, Xia Bai, Yang He, Lijuan Cao, Mingqing Zhu, Changgeng Ruan View Abstract ❯
Values of detection of NF-κB activation level combined with IL-6 and TNF-α levels in peripheral neutrophils in the prediction of multiple organ dysfunction syndrome in patients with severe multiple trauma Jie Zeng View Abstract ❯
Mitochondrial damage in hippocampal neurons of rats with epileptic protein expression of Fas and caspase-3 Junqiang Feng, Lifang Feng, Guiru Zhang View Abstract ❯
Modified Huangqi Chifeng decoction inhibits excessive autophagy to protect against Doxorubicin‑induced nephrotic syndrome in rats via the PI3K/mTOR signaling pathway Zi‑Kai Yu, Bin Yang, Yu Zhang, Liu‑Sheng Li, Jin‑Ning Zhao, Wei Hao View Abstract ❯
Berberine inhibits cardiac remodeling of heart failure after myocardial infarction by reducing myocardial cell apoptosis in rats Ying Liao, Kaihong Chen, Xingmo Dong, Weiguo Li, Ganyang Li, Guoyong Huang, Wei Song, Liling Chen, Yong Fang View Abstract ❯
Effect of ranibizumab on levels of IL-6 and VEGF in peripheral blood and aqueous humor of glaucoma rat model and association of IL-6 and VEGF with optic nerve damage Yanling Song, Qiujie Song, Ling Li, Jinfeng Xu, Xingqiang Liu View Abstract ❯
Automated nasopharyngeal carcinoma segmentation in magnetic resonance images by combination of convolutional neural networks and graph cut Zongqing Ma, Xi Wu, Qi Song, Yong Luo, Yan Wang, Jiliu Zhou View Abstract ❯
Effects of SB202190 on expression levels of IL-6 and NF-κB in flap ischemia-reperfusion injury Kai Guo, Jingxin Ma, Wenyong Liang View Abstract ❯
Clinical significance of circulating tumor cells via combined whole exome sequencing in early stage cancer screening: A case report Zijian Su, Jiangman Zhao, Shaoying Ke, Jian Zhang, Xiaoyu Liu, Yu Wang, Qihong Sun, Qunxiong Pan View Abstract ❯
Bioinformatics identification of potential candidate blood indicators for doxorubicin‑induced heart failure Guo‑Xing Wan, Li‑Hua Ji, Wen‑Bin Xia, Lan Cheng, Yong‑Gang Zhang View Abstract ❯
Meta‑analysis of the benefit of sitagliptin treatment in patients with type 2 diabetes complicated with incipient nephropathy Wei Liu, Jiangyi Yu, Qianhua Yan, Lijuan Wang, Nan Li, Wei Xiong View Abstract ❯
Pulmonary actinomycosis diagnosed by transbronchoscopic lung biopsy: A case report and literature review Xing Ding, Gengyun Sun, Guanghe Fei, Xuexin Zhou, Luqian Zhou, Ran Wang View Abstract ❯
Effect of saxagliptin on the expression of HIF‑1α in the liver of diabetic rats with fatty liver Qian Zhao, Qian Xiao, Xiangying Meng, Jianyang Chen, Weiwei Ye, Yong Zhou View Abstract ❯
Flos Chrysanthemi Indici extract improves a high‑sucrose diet‑induced metabolic disorder in Drosophila Ye Bai, Kun Li, Jiayao Shao, Qiuxiang Luo, Li Hua Jin View Abstract ❯
Effects of hepatic blood inflow on liver ultrastructure and regeneration after extensive liver resection in rats with cirrhosis Wang‑Xun Jin, Bing Wang, Yun‑Li Zhang, Ruizeng Dong, Xin‑Bao Wang, Jian‑Min Guo, Sunfu Fan , Bingqi Yu View Abstract ❯
Analyzing the disease module associated with osteosarcoma via a network‑ and pathway‑based approach Yi Zhang, Fei Yang View Abstract ❯
Luteolin decreases atherosclerosis in LDL receptor‑deficient mice via a mechanism including decreasing AMPK‑SIRT1 signaling in macrophages Jiang Li, Jian‑Zeng Dong, Yan‑Long Ren, Jia‑Jia Zhu, Jia‑Ning Cao, Jing Zhang, Li‑Li Pan View Abstract ❯
Effects of salvianolic acid on cerebral perfusion in patients after acute stroke: A single‑center randomized controlled trial Jian‑Wei Peng, Yuan Liu, Gai Meng, Jin‑Yan Zhang, Lian‑Fang Yu View Abstract ❯
Tumor suppressor function of miR‑483‑3p on breast cancer via targeting of the cyclin E1 gene Xiaoxi Huang, Jin Lyu View Abstract ❯
Quantification of nitric oxide by high‑performance liquid chromatography‑fluorometric method in subgenomic hepatitis C virus‑replicon expressing Huh7 cells upon treatment with acetylsalicylic acid Clara Patricia Rios‑Ibarra, Victor Torres‑De La Cruz, Andrea Gabriela Ochoa‑Ruiz, Ana María Rivas‑Estilla View Abstract ❯
Magnetic wires: A novel design for neuroendovascular coil retrieval Lingyun Zhang, Yugang Jiang View Abstract ❯
Neuroprotective effect of recombinant adeno‑associated virus human thioredoxin‑PR39 on acute cerebral infarction in rats Yu‑Dong Guo, Teng Huang, Wen‑Hua Sheng, Yun‑Fei Guan, Yi‑Feng Du, You‑Ting Lin, Xi‑Yun Ruan View Abstract ❯
Complement 3 glomerulonephritis in rheumatoid arthritis: A case report and follow‑up Xin Wang, Lu Han, Huifang Li, Dongmei Zhang View Abstract ❯
Identification of a novel TCOF1 mutation in a Chinese family with Treacher Collins syndrome Zhiqiang Yan, Yu Lu, Yanfei Wang, Xiuju Zhang, Hong Duan, Jing Cheng, Huijun Yuan, Dongyi Han View Abstract ❯
Activation of EphA4 induced by EphrinA1 exacerbates disruption of the blood‑brain barrier following cerebral ischemia‑reperfusion via the Rho/ROCK signaling pathway Fangbin Chen, Zhiyang Liu, Wei Peng, Zhiqin Gao, Hui Ouyang, Tongjun Yan, Songbai Ding, Zhankui Cai, Bin Zhao, Longjin Mao, Zhiyong Cao View Abstract ❯
Association of cytokine gene polymorphisms with osteoarthritis susceptibility Otilia Constantina Rogoveanu, Daniela Calina, Mihai Gabriel Cucu, Florin Burada, Anca Oana Docea, Simona Sosoi, Emilian Stefan, Mihai Ioana, Emilia Burada View Abstract ❯
miR‑148a inhibits pro‑inflammatory cytokines released by intervertebral disc cells by regulating the p38/MAPK pathway Guangfeng Li, Xianye Tang, Hongliang Chen, Wei Sun, Feng Yuan View Abstract ❯
Tetrandrine alleviates symptoms of rheumatoid arthritis in rats by regulating the expression of cyclooxygenase‑2 and inflammatory factors Xiang Li, Zhongxiu Wu, Bin He, Wei Zhong View Abstract ❯
Recurrent cerebellar infarction associated with hereditary heterozygous protein C deficiency in a 35‑year‑old woman: A case report and genetic study on the pedigree Pingping Li, Chao Qin View Abstract ❯
Biomechanical bearing‑based typing method for osteonecrosis of the femoral head: ABC typing Zhennan Zhang, Tong Yu, Limin Xie, Yubin Li, Xun Ke, Yang Liu, Songmin Huang, Hao Deng, Yang Bai View Abstract ❯
Acetylpuerarin inhibits oxygen‑glucose deprivation‑induced neuroinflammation of rat primary astrocytes via the suppression of HIF‑1 signaling Yanxiao Xiang, Pengchao Du, Xiumei Zhang, Siddhartha Biswas, Guangjun Jiao, Haichun Liu View Abstract ❯
Overexpression of microRNA‑936 suppresses non‑small cell lung cancer cell proliferation and invasion via targeting E2F2 Xiao Zhou, Hui Tao View Abstract ❯
Overexpression of CD64 on CD14++CD16‑ and CD14++CD16+ monocytes of rheumatoid arthritis patients correlates with disease activity Qing Luo, Pengcheng Xiao, Xue Li, Zhen Deng, Cheng Qing, Rigu Su, Jianqing Xu, Yang Guo, Zikun Huang, Junming Li View Abstract ❯
Acute bilateral vision deficit as the initial symptom in Guillain‑Barre syndrome: A case report Hui‑Jun Wen View Abstract ❯
miR‑192 is upregulated in T1DM, regulates pancreatic β‑cell development and inhibits insulin secretion through suppressing GLP‑1 expression Wen Pan, Yanan Zhang, Chun Zeng, Fen Xu, Jinhua Yan, Jianping Weng View Abstract ❯
Adiponectin is valuable in the diagnosis of acute heart failure with renal insufficiency Zhang Dai, Yan Zhang, Huiming Ye, Guoqiang Zhang, Hongwei Jin, Ziming Chen, Yihui Yao, Xuebing Tian, Jianfeng Zhou, Peihua Li, Xianming Liang, Huabing Xie, Shengxiang Ge, Zhongying Zhang View Abstract ❯
Phosphatidylinositol 3‑kinase‑mediated HO‑1/CO represses Fis1 levels and alleviates lipopolysaccharide‑induced oxidative injury in alveolar macrophages Jia Shi, Jianbo Yu, Yuan Zhang, Zhen Li, Lirong Gong, Shuan Dong, Rui Mu View Abstract ❯
Efficacy and tolerability of interferon‑free regimen for patients with genotype‑1 HCV infection Kosuke Takeda, Ryuichi Noguchi, Tadashi Namisaki, Kei Moriya, Takemi Akahane, Mitsuteru Kitade, Hideto Kawaratani, Naotaka Shimozato, Kosuke Kaji, Hiroaki Takaya, Yasuhiko Sawada, Kenichiro Seki, Yukihisa Fujinaga, Yuki Tsuji, Takuya Kubo, Shinya Sato, Soichiro Saikawa, Keisuke Nakanishi, Masanori Furukawa, Koh Kitagawa, Takahiro Ozutsumi, Daisuke Kaya, Akira Mitoro, Tsuyoshi Mashitani, Yasushi Okura, Junichi Yamao, Hitoshi Yoshiji View Abstract ❯
Verteporfin enhances the sensitivity of LOVO/TAX cells to taxol via YAP inhibition Ganggang Shi, Hao Wang, Hongqiu Han, Jianchen Gan, Hui Wang View Abstract ❯
Icariin prevents cytokine‑induced β‑cell death by inhibiting NF‑κB signaling Shao Zhong, Jing Ge, Jiang‑Yi Yu View Abstract ❯
MicroRNA‑126 accelerates IgE‑mediated mast cell degranulation associated with the PI3K/Akt signaling pathway by promoting Ca2+ influx Yuan Bao, Song Wang, Yang Gao, Wen Zhang, Haitao Jin, Yang Yang, Jiangyu Li View Abstract ❯
Tuberculous meningitis diagnosis and treatment in adults: A series of 189 suspected cases Mengchuan Luo, Weifei Wang, Qiuming Zeng, Yuebei Luo, Huan Yang, Xiaosu Yang View Abstract ❯
[Editorial] Does Europe need paediatric virologists? Ioannis N. Mammas, Anne Greenough, Maria Theodoridou, Demetrios A. Spandidos View Abstract ❯
Evaluating the proposal of paediatric virology: An interview with Professor Tina Dalianis, Professor of Tumour Virology at Karolinska Institutet Ioannis N. Mammas, Demetrios A. Spandidos View Abstract ❯
Neonatology, paediatrics and paediatric virology on a British island: An interview with neonatologist Dr Prakash Thiagarajan (Isle of Man) Ioannis N. Mammas, Demetrios A. Spandidos View Abstract ❯
Paediatric virology as a candidate of paediatric subspecialisation: An interview with Assistant Professor of Molecular Microbiology-Virology Angeliki Melidou Ioannis N. Mammas, Demetrios A. Spandidos View Abstract ❯
The philosophy of paediatric teaching: An interview with Dr Nikolaos Myriokefalitakis, former Clinical Director of the 'Penteli' Children's Hospital in Athens (Greece) Ioannis N. Mammas, Demetrios A. Spandidos View Abstract ❯
[Editorial] The future of paediatric education Ioannis N. Mammas, Demetrios A. Spandidos, Alan Michael Weindling View Abstract ❯
The future of medical education in neonatology, paediatrics and paediatric virology: An interview with Professor Alan Michael Weindling, Professor of Perinatal Medicine at the University of Liverpool Ioannis N. Mammas, Demetrios A. Spandidos View Abstract ❯

20-22 September, 2018, Metropolitan Hotel, Athens, Greece 23nd World Congress on Advances in Oncology & 22th International Symposium on Molecular Medicine 18-19 September 2018, Pre-Congress Workshop: 'MicroRNA Analysis'

28-30 March, 2019, Tawana Hotel, Bangkok, Thailand 23 rd International Symposium on Molecular Medicine

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