Investigation of itraconazole ternary amorphous solid dispersions based on povidone and Carbopol

Publication date: 30 August 2017
Source:European Journal of Pharmaceutical Sciences, Volume 106
Author(s): Fan Meng, Jordan Meckel, Feng Zhang
We investigate a ternary system that consists of itraconazole (ITZ) and two polymers: povidone K12 and Carbopol 907. The interactions between these two polymers and their effects on the properties of ternary ITZ amorphous solid dispersions (ASDs) are studied. These two polymers can form a water-insoluble complex in acidic aqueous media. The critical pH is determined to be 4.17. The weight percentage of Carbopol 907 in the interpolymer complex range from 59 to 70%, depending on the initial ratios between these two polymers in the starting solutions. This complexation is driven by a negative enthalpy change from the H-bonding between the two polymers and a positive entropy change from the freed water molecules. Due to the slow precipitation of the interpolymer complex in aqueous media, the attempt to prepare ternary ASD using solvent-controlled coprecipitation is not successful. Melt extrusion is identified to be the only viable method to prepare this ternary ASD. We find that interpolymer complex–based ASDs are physically less stable and demonstrate the poorest drug-release properties when compared to individual polymer-based binary ASDs. This study illustrates that the too strong interaction between polymers in ternary ASDs is detrimental to their performance.

Graphical abstract

http://ift.tt/2s9trlc

Influence of the drug distribution in electrospun gliadin fibers on drug-release behavior

Publication date: 30 August 2017
Source:European Journal of Pharmaceutical Sciences, Volume 106
Author(s): Ying Xu, Jiao-Jiao Li, Deng-Guang Yu, Gareth R. Williams, Jun-He Yang, Xia Wang
Drug distribution within its carrier in a solid dosage form often generates a profound influence on its release profile, particularly when the physicochemical properties of the carrier are exploited to manipulate drug release behavior. In this job, two different types of distributions of a model drug ibuprofen (IBU) within a protein gliadin in their electrospun nanofibers were intentionally created. One was homogeneous distribution in the monolithic fibers fabricated using a modified coaxial process, and the other one was heterogeneous distribution in the core/shell fibers prepared through a traditional coaxial process. SEM observations clearly demonstrated the different distributions of IBU within gliadin in the two kinds of nanofibers although both of them had smooth surfaces and linear morphology. XRD results showed that IBU was amorphously distributed in the monolithic fibers, but that some IBU crystalline lattices presented in the core/shell fibers. FTIR and RM spectra suggested that gliadin had good compatibility with IBU. In vitro dissolution tests verified that the gliadin nanofibers with a heterogeneous drug distribution could provide a better sustained release profile than its counterpart in terms of initial burst release and sustained release time period. Both the fiber formation and drug-controlled release mechanisms are suggested. The present study demonstrated a concept that drug distribution with the medicated nanomaterials can be exploited as a tool to optimize the drug sustained release profile.



http://ift.tt/2s9u9in

Polymer structure-property requirements for stereolithographic 3D printing of soft tissue engineering scaffolds

Publication date: September 2017
Source:Biomaterials, Volume 140
Author(s): Ryan J. Mondschein, Akanksha Kanitkar, Christopher B. Williams, Scott S. Verbridge, Timothy E. Long
This review highlights the synthesis, properties, and advanced applications of synthetic and natural polymers 3D printed using stereolithography for soft tissue engineering applications. Soft tissue scaffolds are of great interest due to the number of musculoskeletal, cardiovascular, and connective tissue injuries and replacements humans face each year. Accurately replacing or repairing these tissues is challenging due to the variation in size, shape, and strength of different types of soft tissue. With advancing processing techniques such as stereolithography, control of scaffold resolution down to the μm scale is achievable along with the ability to customize each fabricated scaffold to match the targeted replacement tissue. Matching the advanced manufacturing technique to polymer properties as well as maintaining the proper chemical, biological, and mechanical properties for tissue replacement is extremely challenging. This review discusses the design of polymers with tailored structure, architecture, and functionality for stereolithography, while maintaining chemical, biological, and mechanical properties to mimic a broad range of soft tissue types.



http://ift.tt/2t7wrTC

Improved anticancer effects of albumin-bound paclitaxel nanoparticle via augmentation of EPR effect and albumin-protein interactions using S-nitrosated human serum albumin dimer

Publication date: September 2017
Source:Biomaterials, Volume 140
Author(s): Ryo Kinoshita, Yu Ishima, Victor T.G. Chuang, Hideaki Nakamura, Jun Fang, Hiroshi Watanabe, Taro Shimizu, Keiichiro Okuhira, Tatsuhiro Ishida, Hiroshi Maeda, Masaki Otagiri, Toru Maruyama
In the latest trend of anticancer chemotherapy research, there were many macromolecular anticancer drugs developed based on enhanced permeability and retention (EPR) effect, such as albumin bound paclitaxel nanoparticle (nab- PTX, also called Abraxane^®). However, cancers with low vascular permeability posed a challenge for these EPR based therapeutic systems. Augmenting the intrinsic EPR effect with an intrinsic vascular modulator such as nitric oxide (NO) could be a promising strategy. S-nitrosated human serum albumin dimer (SNO-HSA Dimer) shown promising activity previously was evaluated for the synergistic effect when used as a pretreatment agent in nab-PTX therapy against various tumor models. In the high vascular permeability C26 murine colon cancer subcutaneous inoculation model, SNO-HSA Dimer enhanced tumor selectivity of nab-PTX, and attenuated myelosuppression. SNO-HSA Dimer also augmented the tumor growth inhibition of nab-PTX in low vascular permeability B16 murine melanoma subcutaneous inoculation model. Furthermore, nab-PTX therapy combined with SNO-HSA Dimer showed higher antitumor activity and improved survival rate of SUIT2 human pancreatic cancer orthotopic model. In conclusion, SNO-HSA Dimer could enhance the therapeutic effect of nab-PTX even in low vascular permeability or intractable pancreatic cancers. The possible underlying mechanisms of action of SNO-HSA Dimer were discussed.

Graphical abstract

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Low expression of long noncoding RNA CASC2 indicates a poor prognosis and promotes tumorigenesis in thyroid carcinoma

Publication date: September 2017
Source:Biomedicine & Pharmacotherapy, Volume 93
Author(s): Xiangqing Xiong, Hua Zhu, Xiangjian Chen
Recently, long noncoding RNAs (lncRNAs) have been shown to be linked to regulate different biological processes, such as cell growth, differentiation and tumorigenesis. LncRNAs have been identified to be promising clinical biomarkers in various tumors. Long noncoding RNAs cancer susceptibility candidate 2 (CASC2) has recently been demonstrated to be correlated to tumorigenesis in renal cell carcinoma, lung carcinoma, glioma, and gastric carcinoma. Nevertheless, the research on the biological function and clinical significance of CASC2 in thyroid carcinoma are still unclear. In this research, we focused on the relationship between CASC2 expression and clinicopathological factors in thyroid cancer. We found that the low expression of CASC2 correlated with multifocality and advanced tumor-node-metastasis (TNM) stage. Kaplan-Meier survival analysis and multivariate analysis showed that CASC2 expression may be an independent prognostic factor in human thyroid carcinoma. Moreover, the area under the receiver operating characteristic (ROC) curve of CASC2 indicated that its diagnostic value in thyroid carcinoma. Additionally, overexpression of CASC2 significantly inhibited the proliferation of thyroid carcinoma cells and arrested cell cycle at G0/G1 stage in thyroid cancer cells. Our findings showed that CASC2 may be a potential prognostic marker and therapeutic target.



http://ift.tt/2s9kLLy

The impact of gut microbiota on kidney function and pathogenesis

Publication date: September 2017
Source:Biomedicine & Pharmacotherapy, Volume 93
Author(s): Fariba Mahmoodpoor, Yalda Rahbar Saadat, Abolfazl Barzegari, Mohammadreza Ardalan, Sepideh V Zununi Vahed
Chronic kidney diseases (CKDs) are a global health problem. Besides diverse leading reasons in initiation and progression of CKDs, it is evident that they might largely originate from changes in the gut microbial community (microbiota). Mounting evidence indicates that a bidirectional relationship exists between host and microbiome in humans and animals with CKDs. Changes in the microbiota composition and structure (dysbiosis) produce excessive amounts of uremic toxins (e.g. indoxyl sulfate, p-cresyl sulfate and trimethylamine-N-oxide) but less reno-protective metabolites that are implicated in oxidative stress, uremia, inflammation, deterioration of kidney function, kidney diseases progression, a higher prevalence of cardiovascular risk, and mortality in patients with CKD. The present review focuses on the pathogenic association between gut microbiota and kidney diseases like CKD, IgA nephropathy, and kidney stone disease. Certainly, novel insights into the impact of the gut microbiota in kidney diseases can be helpful to develop therapeutic strategies in order to avoid and/or treat aforementioned conditions.



http://ift.tt/2sE93MO

Pure total flavonoids from citrus improve non-alcoholic fatty liver disease by regulating TLR/CCL signaling pathway: A preliminary high-throughput ‘omics’ study

Publication date: September 2017
Source:Biomedicine & Pharmacotherapy, Volume 93
Author(s): Liyan Wu, Maoxiang Yan, Jianping Jiang, Beihui He, Wei Hong, Zhiyun Chen
ObjectiveThis study investigated the possible molecular mechanisms of pure total flavonoids from citrus (PTFC) for the treatment of non-alcoholic fatty liver disease (NAFLD) via toll-like receptor/C-C chemokine ligand (TLR/CCL) signaling pathways by monitoring the changes in gene expression profile in liver tissues induced by high-fat diet.MethodsWe performed systematical analyses on hepatic expression profiles of mRNAs in a high-fat diet (HFD)-induced steatotic animal model with or without PTFC treatment. The study was conducted by using MouseOneArray^® v2 gene chip, and analyzed by bioinformatics tools for differential gene expression. Real time-PCR, Western blot and liquid suspension array analysis were used to validate specific genes in the NAFLD liver expression profile in which PTFC plays a role in the TLR/CCR pathway.ResultsWe found that a total of 562 genes showed varying degrees of reversal after PTFC intervention. Pathway analysis of the differential gene expression in the HFD group and the normal diet group (ND group) revealed six signaling pathways related to inflammatory responses in the top ten results. Comparison of genes between the HFD+PTFC and the HFD groups indicated seven signaling pathways correlated with inflammatory response in the top ten results of the pathway analysis. The TLR/CCL inflammatory signaling pathways played an essential role during liver inflammation in NAFLD mice induced by high-fat diet. Real-time PCR, Western blot and liquid suspension array analysis of the differential gene expression involving the TLR/CCL signaling pathways validated the results of microarray detection.ConclusionPTFC may improve NAFLD by regulating TLR/CCL signaling pathways. Genomic studies provide additional evidence supporting the role of PTFC in the treatment of NAFLD.



http://ift.tt/2s9d2gA

Simvastatin prevents morphine-induced tolerance and dependence in mice

Publication date: September 2017
Source:Biomedicine & Pharmacotherapy, Volume 93
Author(s): Nasim Sadat Pajohanfar, Ehsan Mohebbi, Ahmad Hosseini-Bandegharaei, Mohamadraza Amin, Golnaz Vaseghi, Bahareh Amin
BackgroundTolerance to analgesic effects of opioids and dependence to them are main concerns in the treatment of chronic pain conditions, limiting clinical application of these drugs. This study aimed to evaluate the effect of simvastatin on the morphine-induced tolerance and dependence in mice.Material and methodsFor this purpose, mice were treated with either daily morphine (20 mg/kg, s.c.) alone, or in combination with simvastatin (2.5, 5 and 10mg/kg, i.p.), for 9 continuous days. Antinociceptive effect of morphine was assessed through measuring latency time withdrawal of paw exposed to thermal stimulus, in the hot plate test. Naloxone-precipitated morphine withdrawal (5mg/kg, i.p.), was used for dependence evaluation. Changes in brain gene expression levels of induced nitric oxide synthase (iNOS), astroglia marker, glial fibrillary acidic protein (GFAP), ionized calcium-binding protein (Iba1) a microglia activation marker, a pro-inflammatory mediator and tumor necrosis alpha (TNF-α) were measured after withdrawal by real-time polymerase chain reaction (RT-PCR).ResultsBehavioral tests indicated that latency time increased after morphine treatment in the hot plate test. However, this effect decreased on day 7, demonstrating tolerance to antinociceptive effect of morphine. Reduced anti-nociceptive effect of morphine was returned in animals treated with simvastatin (5 and 10mg/kg) in combination with morphine. Simvastatin (5 and 10mg/kg) attenuated morphine dependence as indicated by a less severe antagonist-precipitated withdrawal syndrome. Administration of naloxone was associated with the increased expression of TNF-α, GFAP, Iba1 and iNOS in the brain samples of morphine dependent mice, while the nine days treatment with both 5 and 10mg/kg simvastatin reduced such changes.ConclusionThe obtained results showed that the protective effects of simvastatin against both tolerance to nociceptive effects of morphine as well as withdrawal-induced behavioral profile are meaningful. Inhibition of glia activity as well as antioxidant effects of pharmaceutical simvastatin further proves its neuroprotective property.

Graphical abstract

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Preclinical evidence of the anxiolytic and sedative-like activities of Tagetes erecta L. reinforces its ethnobotanical approach

Publication date: September 2017
Source:Biomedicine & Pharmacotherapy, Volume 93
Author(s): Gimena Pérez-Ortega, Guadalupe Esther Angeles-López, Arturo Argueta-Villamar, María Eva González-Trujano
Morelos State is one of the regions of Mexico where several plant species are used in traditional medicine. Species from Tagetes genus (Asteraceae) are reported as useful in infusion to treat stomachache and intestinal diseases, but also as tranquilizers. In this study, medicinal uses of T. erecta including its depressant effect on the central nervous system (CNS) were explored by interviewing healers and merchants of local markets of Morelos State, and by investigation of the phytochemical and pharmacological tranquilizing properties. Specific anxiolytic and/or sedative-like responses of different doses of T. erecta (10, 30 and 100 or 300mg/kg, i.p.) were investigated using experimental models in mice such as: open-field, exploration cylinder, hole-board, and the barbituric-induced hypnosis potentiation. The possible anxiolytic mechanism of action was assessed in the presence of WAY100635 (0.32mg/kg, i.p.) and flumazenil (10mg/kg, i.p.), antagonists of 5-HT1A and GABA/BDZs receptors, respectively. Individual flavonoids reported in this species were also evaluated in these experimental models. As a result of this study, healers and merchants from ten local regions of Morelos State recommended T. erecta flowers as an infusion or as a tincture for several culture-bound syndromes associated with CNS, among others. Anxiolytic and sedative-like activities of the T. erecta aqueous and organic polar extracts were corroborated in these models associated to a participation of rutin, kaempferol, quercetin, kaempferitrin, and β-sitosterol constituents; where 5-HT1A, but not BDZs, receptors were involved as anxiolytic mechanism of action. These data support the anxiolytic and sedative-like properties of T. erecta in traditional medicine by involving mainly serotonergic neurotransmission because of the presence in part of flavonoids and the terpenoid β-sitosterol.



http://ift.tt/2sDZPzU

SRPX2, an independent prognostic marker, promotes cell migration and invasion in hepatocellular carcinoma

Publication date: September 2017
Source:Biomedicine & Pharmacotherapy, Volume 93
Author(s): Xiaobo Lin, Weiping Chang, Yuan Wang, Ming Tian, Zhaoxiang Yu
Sushi repeat-containing protein X-linked 2 (SRPX2), a novel chondroitin sulfate proteoglycan, is overexpressed in human cancer. Recent studies have reported that SRPX2 overexpression is observed in gastrointestinal cancer, and promotes migration and invasion of cancer cells. While, the clinical significance and biological function of SRPX2 remain rarely known in hepatocellular carcinoma (HCC). Here, we found that the levels of SRPX2 in HCC tissues were notably overexpressed compared to non-cancerous specimens. Accordingly, the levels of SRPX2 were obviously up-regulated in HCC cells compared with LO2 cells. The positive expression of SRPX2 was prominently correlated with venous infiltration and advanced TNM tumor stage. Furthermore, SRPX2 expression acted as an independent prognostic marker for HCC patients. SRPX2 knockdown prominently inhibited the invasion and migration of HCCLM3 cells, while SRPX2 restoration enhanced these cellular biological behaviors of Hep3B cells in vitro. Moreover, SRPX2 knockdown suppressed pulmonary metastasis of HCCLM3 cells in nude mice. Mechanically, SRPX2 knockdown reduced the levels of phosphorylated focal adhesion kinase (p-FAK), p-AKT, matrix metallopeptidase 2 (MMP2) and MMP9 in HCCLM3 cells. In turn, SRPX2 overexpression promoted the activation of FAK/AKT pathway and increased MMP2/9 expression in Hep3B cells. Thus, SRPX2 contributes to migration and invasion of HCC cells probably by targeting FAK/AKT pathway-mediated MMP2/9 expression. SRPX2 potentially acts as an independent prognostic predictor and a drug-target for HCC patients.



http://ift.tt/2s9u6Db

Scholar : Chinese Journal of Otorhinolaryngology, Year 2017, Issue 05 -New Issue Alert.

New Issue TOC Alert Dear Valued Customer, We are pleased to deliver your requested table of contents alert for Chinese Journal of Otorhinolaryngology. Year 2017 Issue 05 is now available on CAOD. In this issue: Transoral microsurgery for the treatment of pharyngeal and laryngeal malignancy (经口咽喉肿瘤微创外科) Xiao Shuifang ...... page:321-324 Transoral radiofrequency coblation surgery for the treatment of hypopharyngeal carcinoma (等离子射频辅助经口手术治疗下咽癌) Xiao Shuifang, ,Li Wuyi, ,Zhang Junbo, ,Wang Jian, ,Jia Junxiao, ,Yang Dahai, ,Zhao Xin, ,Huo Hong, ,Shen Hong ...... page:325-331 Transoral coblation-assisted endoscopic minimally invasive surgery for superficial tongue base tumours (等离子射频辅助经口内镜微创切除浅表舌根肿瘤) Li Wuyi, ,Huo Hong, ,Yang Dahai, ,Liu Jianhan, ,Wang Jian, ,Jin Xiaofeng, ,Niu Yanyan ...... page:332-336 Treatment of glottic cancer involving the anterior commissure by transoral CO2 laser surgery (经口CO2激光手术治疗前连合受累的声门型喉癌疗效观察) Li Jingjia, ,Zhang Jianli, ,He Fayao, ,Tang Sucheng, ,Zhu Zhaofeng, ,Chen Weixiong ...... page:337-342 Preliminary analysis of the effects of tailor-made notched music therapy on chronic idiopathic tinnitus (定制音乐对慢性特发性耳鸣疗效的初步分析) Tian Ruru, ,Diao Mingfang, ,Tian Fangjie, ,Sun Jianjun, ,Lin Xi ...... page:343-348 Effects of noise competition on monosyllabic and disyllabic word perception in children (不同类型噪声竞争对儿童单、双音节词汇识别的影响) Liu Haihong, ,Liu Sha, ,Li Ying, ,Zheng Zhipeng, ,Jin Xin, ,Li Jing, ,Ren Cuncun, ,Zheng Jun, ,Zhang Jie, ,Chen Min, ,Hao Jinsheng, ,Yang Yang, ,Liu Wei, ,Ni Xin ...... page:349-354 xin xi dong tai (信息动态) ...... page:354,391-392 Changing analysis of allergic rhinitis inhalant allergen spectrum in Xinjiang region (新疆维吾尔自治区变应性鼻炎患者吸入变应原谱变化分析) Yang Yuping, ,Maimaiti Yimin, ,Wang Yan, ,Wang Lingling, ,Tan Guoping, ,Zhang Hua ...... page:355-360 Effect of intranasal excision on nasal vestibular cyst under nasal endoscopy (内镜下经鼻行鼻前庭囊肿完整剥除术的疗效观察) Hao Kaifei, ,Yan Zhaohui, ,Tao Shudong ...... page:361-364 Clinical efficacy of endoscopic nasopharyngectomy for initially diagnosed advanced nasopharyngeal carcinoma (内镜手术治疗首诊局部晚期鼻咽癌的疗效分析) Qiu Qianhui, ,Li Na, ,Zhang Qiuhang, ,Chen Zhuo, ,Huang Yan, ,Jiang Yan, ,Yang Xiaotong ...... page:365-371 Diagnostic value of enhanced CT/MRI for thyroid cartilage invasion by malignant tumor (增强CT/MRI对恶性肿瘤侵犯甲状软骨的诊断价值研究) Li Haiyang, ,Chen Xiaohong ...... page:372-376 Clinical characteristics in children with cleft palate associated with middle ear cholesteatoma (儿童期腭裂合并中耳胆脂瘤患儿临床特征分析) Yang Yang, ,Chen Min, ,Hao Jinsheng, ,Liu Wei, ,Zhang Jie ...... page:377-380 Clinical and pathological analyses of 154 patients with white lesion of vocal cord (声带黏膜白色病变154例病理表现及预后分析) Ren Jia, ,Yang Hui, ,Lyu Dan, ,Zou Jian, ,Zheng Yitao, ,Wang Haiyang ...... page:381-384 Clinic features of laryngeal carcinosarcoma and sarcomatoid carcinoma (喉肉瘤样癌及癌肉瘤临床分析) Li Yongjin, ,Li Wuyi, ,Wang Jian, ,Gao Zhiqiang, ,Qi Fang, ,Jiang Hong ...... page:385-387 One case of conductive deafness caused by pulsatile tinnitus (搏动性耳鸣致传导性耳聋一例) Lu Feicai, ,Cai Chang, ,Zhou Peng, ,Li Peihua, ,Liu Wen ...... page:388-389 Primary intraosseous squamous cell carcinoma arising from dentigerous cyst: a case report (上颌骨含牙囊肿癌变一例) Xiang Lin, ,Sun Le, ,Gao Feng, ,Jin Peng, ,Du Bo ...... page:390-391 Two cases of bronchogenic cyst (颈部支气管源性囊肿二例) Gao Feng, ,Zhang Yan, ,Jin Peng, ,Gong Meiheng, ,Du Bo ...... page:393-394 Use of minimally invasive surgical approach in the pharyngolaryngology (经口微创手术方式的选择及其在咽喉科的应用) Zheng Hongliang, ,Zhang Caiyun ...... page:395-400 CAOD TOC Alerts Note Thank you for choosing CAOD Table of Contents (TOC) Alert Service. You are receiving this email because you have requested to receive information from CAOD as a registered user of our Table of Content Alert for journals. To manage your TOC Alerts, please click here. For all enquiries, problems or suggestions regarding this service, please contact info@oriprobe.com. China/Asia on Demand (CAOD) Customer Service

Scholar : Journal of Clinical Stomatology, Year 2017, Issue 05 -New Issue Alert.

New Issue TOC Alert Dear Valued Customer, We are pleased to deliver your requested table of contents alert for Journal of Clinical Stomatology. Year 2017 Issue 05 is now available on CAOD. In this issue: Effects of chlorhexidine solution on different stages of Enterococcus faecalis biofilms (洗必泰溶液对不同时期粪肠球菌生物膜作用效果的实验研究) TANG Xue-zhi, ,DU Tian-feng, ,SHI Qi, ,DING Xiao-xiao, ,YAO Yi-chen, ,CAO Ying-guang ...... page:259-262 The study on stress distribution of different neck design dental implants:a finite element analysis (不同颈部螺纹设计种植体周围牙槽骨应力分布的三维有限元分析) NIU Wen-zhi, ,YUAN Yuan, ,LIU Zong-xiang, ,DONG Wen-jing, ,WANG Peng-lai ...... page:262-265 Comparison of the effects of different disinfectants on the properties of denture base resins (不同消毒剂对义齿基托树脂性能影响的研究) QIN Xiao-feng, ,WANG Lei, ,Xu Sheng, ,SU Xiao-hui ...... page:266-269 Meta-analysis of association between matrix metalloproteinase-1 polymorphism and susceptibility of oral cancer (基质金属蛋白酶-1启动子基因多态性与口腔癌易感性的Meta分析) YANG Yun-qiang, ,SHAO Le-nan, ,JIANG Liang, ,HU Ting ...... page:270-272 Study of shear bond strength between IPS emax CAD ceramics and three luting cements in vitro (三种水门汀对IPS emax CAD陶瓷剪切强度的体外研究) ZHANG Zhi-sheng, ,ZHU Jian-Yu, ,ZUO Qi-liang, ,ZHANG Yi, ,SU Jian-sheng, ,LIU Wei-cai ...... page:273-275 Expression of Rho protein in oral leukoplakia and oral squamous cell carcinoma (Rho亚家族蛋白在口腔白斑和口腔鳞癌中的表达及意义) WANG Ying, ,LU Xufei, ,WANG Qimin, ,HAN Jinhong, ,TONG Lei, ,GUO Qingyuan, ,CHEN Zhenggang ...... page:276-279 Comparative study on the differential levels of humoral and cellular immunity indexes between refractory and general recurrent aphthous ulcer (顽固性与普通性复发性阿弗他溃疡体液和细胞免疫水平的比较研究) RUAN Huan-huan, ,WANG Xiang, ,DUAN Ning, ,SONG Yue-feng, ,JIANG Hong-liu, ,LI Jing-jing, ,FU Yi-fu, ,WANG Wen-mei ...... page:280-283 Analysis of imaging finding and classification in jaw bone islands on cone beam CT (颌骨骨岛的CBCT影像分析及分型) HE Shuang-shuang, ,LIU Yuan-yuan, ,SONG Xue-juan, ,WANG Hu, ,DAI Jia-qi ...... page:283-285 Study on the stability of the arch width in the patients with unilateral cleft lip and palate after unilateral expansion with modified lip bumper (改良唇挡单侧扩弓后单侧完全性唇腭裂患者牙弓宽度稳定性的研究) WANG Yun-jun, ,WANG Yun-e, ,ZHAO Shi-jun, ,ZHAO Wei-wei, ,WANG Jing, ,LIU Jing, ,CAO Yu-jiao ...... page:286-289 The influence of root canal irrigation on the accuracy of RAYPEX 6 and PROPEX Ⅱ electronic apex locator (根管冲洗液对RAYPEX 6及PROPEX Ⅱ电子根尖定位仪测量准确性的影响) HU Yu-feng, ,ZHU Jing, ,WANG Li-qin, ,JIN Wen-zhong ...... page:289-291 Effect of cognitive behavioral therapy combined with Kangfuxin liquid on burning mouth syndrome (认知行为疗法联合康复新液治疗原发性灼口综合征的临床研究) XU Li, ,ZHU Guang-xun ...... page:292-294 Influences of bypassing fractured instrument on apical surface morphology (旁路通过术对根尖孔表面形态影响的研究) XU Rong-rong, ,YANG Ya-ping, ,WANG Wen-mei ...... page:294-296 The comparison of clinical effect between immediate impant and delayed implant in dental restoration of tooth-missing (即刻种植与延迟种植在牙齿缺失修复中的临床疗效观察) DU Jin-hui, ,LIU Yi-han, ,XU li, ,CHEN Jian-gang ...... page:297-300 Study on the influence of personality characteristics on oral health-related quality of life in patients with oral lichen planus (OLP患者人格特征对口腔健康相关生活质量的影响) PAN Yu-xia, ,WONG Sheng-xin, ,ZHEN Rong, ,CHEN Mu, ,WU Jian ...... page:300-302 Evaluating of the mental foramen region based on CBCT (基于锥形束CT的颏孔区测量分析) CAO Kun, ,LI Jia-feng, ,BAO Qiang, ,LU Qiu-ning ...... page:303-305 Digital restorative dentistry and prosthodontics(33)——Three dimensional analysis of the accuracy of different scanners (数字化口腔修复(33)——不同扫描仪精度的三维分析) LIN Zhi-xing, ,YAO Jiang-wu ...... page:306-309 xi du yu kou qiang zuo mo ji bing (吸毒与口腔黏膜疾病) ZHAO Kui ...... page:310-312 quan ci cai liao zai kou qiang xiu fu zhong de ying yong (全瓷材料在口腔修复中的应用) ZHAO Xinran ...... page:312-314 bai jie su -6 zai kou qiang bian ping tai zuo zhong de yan jiu jin zhan (白介素-6在口腔扁平苔藓中的研究进展) SUN Zuozuo ...... page:315-316 zhi chi ba chu shu yu xia zuo jiao gu zhe xiang guan yin su de yan jiu jin zhan (智齿拔除术与下颌角骨折相关因素的研究进展) LIN Yangyang ...... page:317-319 xia zuo di yi heng mo ya liu gen guan 1 li (下颌第一恒磨牙六根管1例) LIU Caiyun, ,HOU Zhouwen, ,DONG Hong, ,LONG Mingsheng ...... page:前插1 CAOD TOC Alerts Note Thank you for choosing CAOD Table of Contents (TOC) Alert Service. You are receiving this email because you have requested to receive information from CAOD as a registered user of our Table of Content Alert for journals. To manage your TOC Alerts, please click here. For all enquiries, problems or suggestions regarding this service, please contact info@oriprobe.com. China/Asia on Demand (CAOD) Customer Service

Scholar : Journal of Practical Stomatology, Year 2017, Issue 03 -New Issue Alert.

New Issue TOC Alert Dear Valued Customer, We are pleased to deliver your requested table of contents alert for Journal of Practical Stomatology. Year 2017 Issue 03 is now available on CAOD. In this issue: A tentative exploration of the expression of B-1a cells in mice with obesity and periodontal infection (肥胖伴牙周感染小鼠体内B-1a细胞的表达初探) WANG Yixiong, ,YU Ting, ,XIE Baoyi, ,XUAN Dongying, ,ZHANG Jincai ...... page:287-291 The effects of hypoxia on the formation and biological properties of mouse adipose-derived stem cell sheet (低氧条件对小鼠ADSCs膜片形成及其生物学特性的影响) ZHOU Yuchao, ,GAO Xiaotong, ,LIU Xiangwei, ,TAN Naiwen, ,WEI Hongbo, ,SONG Yingliang ...... page:292-296 The effectiveness of scaffolds of calcium phosphate cement composites on jaw defect repair (磷酸钙复合材料构建模式对颌骨缺损修复效率的影响) LI Yuan, ,WU Di, ,WANG Tianzuo, ,ZHOU Hongzhi, ,HU Kaijin ...... page:297-301 Study on the fit of titanium alloy removable partial denture framework fabricated by selective laser melting (选择性激光熔覆(SLM)钛合金可摘局部义齿支架的适合性研究) LIU Yifan, ,WANG Weina, ,YU Hai, ,MA Rui, ,WU Bing, ,GAO Bo ...... page:302-305 The role of SR-BⅡ in the oxidized low density lipid induced foam cell formation promoted by porphyromonas gingivalis (B类Ⅱ型清道夫受体在牙龈卟啉单胞菌影响泡沫细胞形成中的作用) HE Xiaoli, ,LIANG Dongyu, ,LIU Feng, ,CHEN Jianxia, ,LUO Lijun ...... page:306-311 Study on the mechanism of TMJ injury caused by high speed fragment impact on pig mandible (高速破片冲击猪下颌骨对颞下颌关节损伤机制的研究) JIA Junzuo, ,WANG Jingfu, ,ZHAO Yimin, ,TIAN Lei, ,MA Qin ...... page:312-315 Control of the maxillary occlusal plane by micro-implant in the process of en-mass retraction:A finite element analysis (内收前牙时微种植钉调控牙合平面的有限元分析) ZHOU Xuezhong, ,CEN Wanjing, ,KONG Weidong ...... page:316-321 The effects of sinter temperature on the crystalline phase and microstructural evolution of lithium disilicate glass-ceramic (烧结温度对二硅酸锂玻璃陶瓷析晶和微结构的影响) WANG Bin, ,XIAO Yun, ,ZUO Qiliang ...... page:322-326 The effects of experimental periodontitis on serum C reactive protein and insulin resistance in obese rats (实验性牙周炎对肥胖大鼠血清C反应蛋白及胰岛素抵抗的影响) ZHONG Sulan, ,NI Jia, ,CHAI Qiaoxue, ,ZHANG Jincai, ,CHEN Lei ...... page:327-330 A preliminary study of the CaO/ZnO nanocore-shell structured antibacterial material (CaO/ZnO核-壳结构纳米材料抗菌性能的初步研究) WANG Lili, ,SUN Yuanqing, ,ZHANG Yingli, ,SUN Hongchen, ,LIN Quan, ,YU Weixian, ,LI Xiangwei ...... page:331-334 Adipose-derived stem cells promote ectopic cartilage fomation by injectable "chondrocyte brick enriched platelet rich plasma gel" (脂肪干细胞促进可注射性"软骨细胞砖-富血小板血浆"复合体形成异位软骨的实验研究) LI Zhiye, ,DONG Yan, ,FENG Xiaozuo, ,CAO Qiang, ,WU Zuo, ,BA Zuozuo, ,ZHAO Yimin ...... page:335-338 The effects of human dental pulp stem cells-conditioned medium on the osteogenic differentiation of human dental follicle stem cells in vitro (人牙髓细胞条件培养液对人牙囊细胞成骨分化作用的体外研究) TAO Yu, ,YU Jinfeng, ,CHEN Jun, ,YU Yong ...... page:339-343 Exosomes serected by mesenchymal stem cells derived form orofacial bone regulate the function of macrophage (人颌骨间充质干细胞的外泌体在巨噬细胞调控中的作用) YUAN Lin, ,CAO Yina, ,YANG Zhengyi, ,SUN Jin, ,PAN Guangsi, ,QIAN Jun, ,SONG Jingjing, ,WANG Han ...... page:344-348 Analysis of the profile esthetics of children with skeletal class Ⅲ malocclusion treated with micro-implant (种植支抗前牵引矫治儿童骨性Ⅲ类错牙合后硬软组织变化的临床研究) KANG Jing, ,PENG Minghui ...... page:349-353 The effect of semiconductor laser irradiation on root cannal seal (半导体激光照射对牙齿根尖封闭效果的研究) SU Dandan, ,SUN Huibin, ,WANG Dashan, ,CUI Ting, ,YAO Ruyong ...... page:354-357 Volumetric changes of upper airway after rapid maxillary expansion:A Meta analysis (上颌快速扩弓后上气道容积变化的Meta分析) SONG Lin, ,XIAO Weiwei, ,FU Tengfei, ,GAO Meng, ,QIN Zaixiu, ,LI Yongming ...... page:358-363 A CBCT study of the hard tissue morphology of the maxillofacial region in adult patients with deep overbite in Liaoning area (辽宁地区成人深覆(牙合)患者颌面部硬组织形态特征的CBCT研究) CHENG Jin, ,LIU Dongmei, ,ZENG Zhaobin, ,LI Yonggang, ,FENG Xue ...... page:364-367 3D measurements and comparison of facial soft tissue of Chinese Han male and female adults with normal occlusion (汉族正常(牙合)成年男女面部软组织三维测量与对比研究) WANG Jiashuai, ,GAO Jie, ,QIN Zaixiu, ,ZHAO Yan, ,HE Xiaotian, ,GUO Donghui, ,JIN Zuolin ...... page:368-373 Influence of mandibular sagittal split back surgery on temporomandibular joint (下颌骨矢状劈开后退术对颞下颌关节的影响) ZHANG Yucan, ,ZHANG Wuyang, ,JIA Junzuo, ,CHANG Shiping, ,LIU Yang, ,MA Qin ...... page:374-376 The effects of GSK-3β on orthodontic tooth movement (GSK-3β对正畸牙齿移动的影响) SUN Cong, ,LIU Wenjia, ,JIN Yan, ,JIN Zuo ...... page:377-380 Correlations of pulp chamber height and dentine thickness of mandibular first molar with age in Chinese Han population based on cone beam computed tomography (基于CBCT对汉族人下颌第一恒磨牙髓室高度及牙本质厚度与年龄关系的研究) LIU Yan, ,NIU Zhongying, ,WANG Rui, ,YAN Shu, ,ZHANG Jianzhong, ,TANG Chuhua, ,SHI Sumeng ...... page:381-384 Curative effects of Jianpijiedutang combined with Kangfuxin Liquid in the treatment of recurrent oral ulcer (健脾解毒汤治疗复发性口腔溃疡的疗效观察) WANG Tingting, ,GU Jinghui, ,SHEN Lin, ,YU Shuling ...... page:385-387 Clinical outcomes of implant-retained overdentures:A retrospective study (种植覆盖义齿临床疗效的回顾性研究) ZHOU Huan, ,ZHANG Lei, ,YU Fan, ,YU Haohan, ,LIU Zhengya, ,XIA Yuning, ,OU Yanggang, ,CHEN Jihua ...... page:388-392 The effects of one-off root canal therapy using iRoot SP for chronic apical periodontitis with sinus in anterior teeth (iRoot SP一次性根管治疗前牙窦道型慢性根尖周炎疗效观察) LI Xiang, ,CAI Xingwei, ,HE Xin, ,ZHANG Na ...... page:393-396 Bactericidal effect of nano-silver against E.faecalis growing in multi-species biofilm (纳米银对多菌种生物膜中粪肠球菌的杀菌作用) ZHANG Fuhua, ,LI Mao, ,WEI Zhijun, ,ZHANG Jianfeng ...... page:397-400 A preliminary study of the maximum volume of oral cavity (口腔最大容积初探) LIN Jie, ,ZHOU Kaidan, ,LIN Zhenxiang, ,ZHENG Zhiqiang, ,WANG Meizhi, ,LU Zhaojie ...... page:401-403 cd73 zai e xing zhong liu zhong zuo yong ji zhi de yan jiu jin zhan (CD73在恶性肿瘤中作用机制的研究进展) REN Zhenhu, ,YUAN Yongxiang, ,JI Tong, ,ZHANG Chenping ...... page:404-409 Clinical analysis of the shaping ability of Hyflex CM rotary NiTi files in curved root canals (Hyflex CM机用镍钛锉预备磨牙弯曲根管的临床分析) YAN Xuebing, ,XIAO Yao, ,LUO Shusheng, ,WENG Jinlong, ,PENG Hong, ,LIU Li, ,SONG Aiping ...... page:410-413 The clinical application of modified adams clasp (长箭头卡的临床应用) BEI Min, ,LI Huang, ,JI Tong, ,JI Jun, ,DING Xiaoqing ...... page:413-414 Mandibular deformation by the decompression treatment of large unicystic ameloblastom:Report of 2 cases (成釉细胞瘤开窗减压治疗后下颌骨形态改变的临床观察2例) LEI Donghui, ,AN Shichang ...... page:415-417 Non-syndromic majority teeth congenital absence:Mother and daughter of two cases (非综合征型先天性多数牙缺失母女2例) ZHANG Kun, ,GAO Yang, ,XIN Juntong ...... page:417-419 Pleomorphic hyalinizing vascular tumor of neck soft tissue:Report of 1 case (颈部软组织多形性透明变性血管扩张性肿瘤1例) LI Zhangyi, ,ZHANG Shuai ...... page:420-422 wai pei ceng fa yu bu quan que ya de zhong zhi xiu fu zhi liao (外胚层发育不全缺牙的种植修复治疗) WANG Kun, ,TAN Yinghui ...... page:423-426 CAOD TOC Alerts Note Thank you for choosing CAOD Table of Contents (TOC) Alert Service. You are receiving this email because you have requested to receive information from CAOD as a registered user of our Table of Content Alert for journals. To manage your TOC Alerts, please click here. For all enquiries, problems or suggestions regarding this service, please contact info@oriprobe.com. China/Asia on Demand (CAOD) Customer Service

Scholar : Chinese Journal of Otorhinolaryngology In Integrative Medicine, Year 2017, Issue 02 -New Issue Alert.

New Issue TOC Alert Dear Valued Customer, We are pleased to deliver your requested table of contents alert for Chinese Journal of Otorhinolaryngology In Integrative Medicine. Year 2017 Issue 02 is now available on CAOD. In this issue: A preliminary evaluation on the association of spleen-stomach damp-heat with experimental allergic rhinitis among mice (脾胃湿热与变应性鼻炎模型小鼠相关性的初步研究) QU Jing, ,LIAN Haihong, ,LIU Chang, ,WANG Xiangdong ...... page:81-84 Effect of negative pressure drainage on IL-1β, CRP and PGE2 levels in patients with acute periapical periodontitis (负压引流对急性根尖周炎患者IL-1β、0CRP及PGE2水平的影响及疗效研究) LI Qiaouying, ,JIA Qing, ,LI Yanxia ...... page:85-87,108 Using glucocorticoids effect evaluation for the treatment of secre tory otitis media (分泌性中耳炎采用糖皮质激素治疗的效果评价) WANG Guifang, ,HAO Yuanyuan, ,WANG Tingliang, ,HUANG Guanhui, ,CHEN Baoshu, ,HU Mingqing ...... page:88-90,98 Study of eosinophils in the pathogenesis of chronic rhinosinusitis (嗜酸性粒细胞在慢性鼻-鼻窦炎发病中表现的探讨) WANG Jie, ,JI Dong, ,GUI Xiaozhong ...... page:91-93 Efficacy observation of longdan xiegan decoction combined with western medicine in chronic rhinosinusitis without nasal polyps (龙胆泻肝汤结合西药治疗慢性鼻-鼻窦炎不伴鼻息肉患者的临床观察) CHEN Tingting, ,GUO Qiyun, ,LIU Jiaqi, ,LIU Liting ...... page:94-98 Efficacy of Low Temperature Plasma Ablation on Allergic Rhinitisand its Influence on Quality of Life (低温等离子消融术治疗变应性鼻炎的疗效及对患者生活质量影响的分析) LIU Tao, ,GU Linglan, ,XU Weimin ...... page:99-101,108 Clinical effect of transposition of septal deviation in the treatment of Type C deviation of septal cartilage (鼻中隔偏曲位移术在处理鼻中隔软骨部"C"型偏曲时的优点及其疗效观察) WU Xiangping, ,QIU Ruoqing, ,TANG Zhiping ...... page:102-104,111 The clinical effects of microwave thermocoagulation on the chronic rhinosinusitis patients after nasal endoscope surgery (微波热凝在慢性鼻窦炎鼻内镜术后处理的应用探讨) ZENG Wei, ,HUANG Jia, ,GENG Juanjuan, ,YUKE Hua ...... page:105-108 Implications of adenoidectomy in the treatment of children with chronic sinusitis (腺样体切除对儿童慢性鼻窦炎治疗效果的影响) LIN He, ,TAN Yenong ...... page:109-111 The effect of nasal irrigation with compound azithromycin solution on the recovering process of mucosa in sinus cavity with chronic lesion treated by endoscopic surgery (阿奇霉素混合制剂鼻腔灌洗在鼻窦炎内镜术后恢复中的应用观察) ZHAO Jing, ,JIA Jingmian, ,WANG Mei, ,WANG Jiechao, ,MA Xiaofeng, ,WANG Xing ...... page:112-114 Curative effect observation of Low temperature plasma radiofrequency ablation technique in adult tonsillectomy (低温等离子射频消融术行成人扁桃体切除的疗效观察) XIE Fang, ,CHEN Weihu, ,HU Chunjiu, ,WANG Yonggan ...... page:115-117 YiQiYangXueQuFeng granules in treatment of children's laryngeal cough curative effect observation (益气养血祛风颗粒剂治疗儿童喉源性咳嗽疗效观察) MA Shengmin, ,LIU Fu-guan, ,CHEN Huashan, ,JI Hong, ,XU Lihua, ,LI Suling ...... page:118-121 Curative effect observation of oral proton pump inhibitors in the treatment of laryngeal contact granuloma (口服质子泵抑制剂治疗喉接触性肉芽肿的疗效观察) XU Zhijian, ,LUO Huizhen, ,ZHONG Xiaoyan, ,LIAO Yanping, ,DU Baowen ...... page:122-123,136 Therapeutic effect of simultaneously multiple plane surgical procedures on severe OSAHS and an analysis on associated risk factors responsible for its prognosis (OSAHS多阻塞平面同期手术的疗效观察及相关影响因素分析) RUAN Yijing, ,SHI Xiongzhou, ,LIU Qian, ,XUE Yuanqiong, ,WU Tao, ,CAI Zhuo ...... page:124-128 Anesthesia selection for head and neck surgery with difficult airway (合并困难气道头颈外科手术的麻醉选择) LIU Weiwei, ,LIU Yehai, ,LI Yuanhai, ,LU Xianfu, ,CHEN Lijian, ,WANG Qin, ,WU Jing, ,ZHANG Liang ...... page:129-132,147 Clinical observation on the therapeutic effect of simultaneously dental implanting procedures on patients with mucosa perforation in the sinus bottom complicated from intra-maxillary ascension for repairing missed maxillary molar (上颌窦内提升术中发生窦底黏膜穿孔的上颌磨牙缺失患者同期行种植体植入修复的效果观察) ZHAO Zhengguo, ,DING Meijun, ,YAN An ...... page:133-136 Therapeutic effect and safety comparison between piezosurgery and chisel osteotomy in the extraction of impacted mandibular third molars (凿骨劈冠法与超声骨刀法拔除下颌阻生智齿的临床效果与安全性比较) PENG Fengying, ,SHAO Zhuona, ,TIAN Zhijiang ...... page:137-138,142 mei ni ai bing huan zhe mri zao ying suo jian nei lin ba ji shui cheng du de lin chuang xiang guan xing yan jiu (梅尼埃病患者MRI造影所见内淋巴积水程度的临床相关性研究) YAO Shihong, ,JIN Pan, ,HU Tao, ,SUN Lujun ...... page:139-142 lian he gao ya yang zhi liao tu fa xing long shi jian xuan ze yu liao xiao fen xi (联合高压氧治疗突发性聋时间选择与疗效分析) LI Hui, ,ZENG Qingxiang ...... page:143-145,136 di wen deng li zi xiao rong shu zhi liao chang nian xing er tong bian ying xing bi yan de lin chuang fen xi (低温等离子消融术治疗常年性儿童变应性鼻炎的临床分析) QU Lingmei, ,HU Xiao, ,LI Chunyu ...... page:146-147 bi nei jing xia bi zhong ge pian qu jiao zheng shu hou "8" zi feng he bi zhong ge mian de lin chuang guan cha (鼻内镜下鼻中隔偏曲矫正术后"8"字缝合鼻中隔面的临床观察) WEI Dangjun, ,YAO Kun ...... page:148-149,93 nan zhi xing bi zuo yan bi nei jing shou shu lian he zhong yao " cang er zi san " ying yong 78 li liao xiao guan cha (难治性鼻窦炎鼻内镜手术联合中药"苍耳子散"应用78例疗效观察) HOU Xiaobing, ,XIA Jingjing, ,WANG Jun, ,XIAO Shuzhen ...... page:150-152 chen tong dao nian liu ren hua jiao shou (沉痛悼念刘认华教授) SUN Jingwu ...... page:152 gu zhong tang zai zhong yi er bi yan hou ke zhong de yun yong ju yu (固中汤在中医耳鼻咽喉科中的运用举隅) PENG Lingyan ...... page:153-154 ying mo wai ma zui dao guan yin dao xia shou shu zhi liao sai lie zuo guan de fen xi (硬膜外麻醉导管引导下手术治疗鳃裂瘘管的分析) LIU Yan, ,LIU Jijiang ...... page:155-157 Effect evaluation of humanized nursing which is applied in the treatment of ENT department (耳鼻喉门诊治疗室中应用人性化护理的效果评价) ZHOU Meirong ...... page:158-160,157 CAOD TOC Alerts Note Thank you for choosing CAOD Table of Contents (TOC) Alert Service. You are receiving this email because you have requested to receive information from CAOD as a registered user of our Table of Content Alert for journals. To manage your TOC Alerts, please click here. For all enquiries, problems or suggestions regarding this service, please contact info@oriprobe.com. China/Asia on Demand (CAOD) Customer Service

Scholar : Chinese Journal of Otorhinolaryngology Head and Neck Surgery, Year 2017, Issue 05 -New Issue Alert.

New Issue TOC Alert Dear Valued Customer, We are pleased to deliver your requested table of contents alert for Chinese Journal of Otorhinolaryngology Head and Neck Surgery. Year 2017 Issue 05 is now available on CAOD. In this issue: Transoral microsurgery for the treatment of pharyngeal and laryngeal malignancy (经口咽喉肿瘤微创外科) Xiao Shuifang ...... page:321-324 Transoral radiofrequency coblation surgery for the treatment of hypopharyngeal carcinoma (等离子射频辅助经口手术治疗下咽癌) Xiao Shuifang, ,Li Wuyi, ,Zhang Junbo, ,Wang Jian, ,Jia Junxiao, ,Yang Dahai, ,Zhao Xin, ,Huo Hong, ,Shen Hong ...... page:325-331 Transoral coblation-assisted endoscopic minimally invasive surgery for superficial tongue base tumours (等离子射频辅助经口内镜微创切除浅表舌根肿瘤) Li Wuyi, ,Huo Hong, ,Yang Dahai, ,Liu Jianhan, ,Wang Jian, ,Jin Xiaofeng, ,Niu Yanyan ...... page:332-336 Treatment of glottic cancer involving the anterior commissure by transoral CO2 laser surgery (经口CO2激光手术治疗前连合受累的声门型喉癌疗效观察) Li Jingjia, ,Zhang Jianli, ,He Fayao, ,Tang Sucheng, ,Zhu Zhaofeng, ,Chen Weixiong ...... page:337-342 Preliminary analysis of the effects of tailor-made notched music therapy on chronic idiopathic tinnitus (定制音乐对慢性特发性耳鸣疗效的初步分析) Tian Ruru, ,Diao Mingfang, ,Tian Fangjie, ,Sun Jianjun, ,Lin Xi ...... page:343-348 Effects of noise competition on monosyllabic and disyllabic word perception in children (不同类型噪声竞争对儿童单、双音节词汇识别的影响) Liu Haihong, ,Liu Sha, ,Li Ying, ,Zheng Zhipeng, ,Jin Xin, ,Li Jing, ,Ren Cuncun, ,Zheng Jun, ,Zhang Jie, ,Chen Min, ,Hao Jinsheng, ,Yang Yang, ,Liu Wei, ,Ni Xin ...... page:349-354 xin xi dong tai (信息动态) ...... page:354,391-392 Changing analysis of allergic rhinitis inhalant allergen spectrum in Xinjiang region (新疆维吾尔自治区变应性鼻炎患者吸入变应原谱变化分析) Yang Yuping, ,Maimaiti Yimin, ,Wang Yan, ,Wang Lingling, ,Tan Guoping, ,Zhang Hua ...... page:355-360 Effect of intranasal excision on nasal vestibular cyst under nasal endoscopy (内镜下经鼻行鼻前庭囊肿完整剥除术的疗效观察) Hao Kaifei, ,Yan Zhaohui, ,Tao Shudong ...... page:361-364 Clinical efficacy of endoscopic nasopharyngectomy for initially diagnosed advanced nasopharyngeal carcinoma (内镜手术治疗首诊局部晚期鼻咽癌的疗效分析) Qiu Qianhui, ,Li Na, ,Zhang Qiuhang, ,Chen Zhuo, ,Huang Yan, ,Jiang Yan, ,Yang Xiaotong ...... page:365-371 Diagnostic value of enhanced CT/MRI for thyroid cartilage invasion by malignant tumor (增强CT/MRI对恶性肿瘤侵犯甲状软骨的诊断价值研究) Li Haiyang, ,Chen Xiaohong ...... page:372-376 Clinical characteristics in children with cleft palate associated with middle ear cholesteatoma (儿童期腭裂合并中耳胆脂瘤患儿临床特征分析) Yang Yang, ,Chen Min, ,Hao Jinsheng, ,Liu Wei, ,Zhang Jie ...... page:377-380 Clinical and pathological analyses of 154 patients with white lesion of vocal cord (声带黏膜白色病变154例病理表现及预后分析) Ren Jia, ,Yang Hui, ,Lyu Dan, ,Zou Jian, ,Zheng Yitao, ,Wang Haiyang ...... page:381-384 Clinic features of laryngeal carcinosarcoma and sarcomatoid carcinoma (喉肉瘤样癌及癌肉瘤临床分析) Li Yongjin, ,Li Wuyi, ,Wang Jian, ,Gao Zhiqiang, ,Qi Fang, ,Jiang Hong ...... page:385-387 One case of conductive deafness caused by pulsatile tinnitus (搏动性耳鸣致传导性耳聋一例) Lu Feicai, ,Cai Chang, ,Zhou Peng, ,Li Peihua, ,Liu Wen ...... page:388-389 Primary intraosseous squamous cell carcinoma arising from dentigerous cyst: a case report (上颌骨含牙囊肿癌变一例) Xiang Lin, ,Sun Le, ,Gao Feng, ,Jin Peng, ,Du Bo ...... page:390-391 Two cases of bronchogenic cyst (颈部支气管源性囊肿二例) Gao Feng, ,Zhang Yan, ,Jin Peng, ,Gong Meiheng, ,Du Bo ...... page:393-394 Use of minimally invasive surgical approach in the pharyngolaryngology (经口微创手术方式的选择及其在咽喉科的应用) Zheng Hongliang, ,Zhang Caiyun ...... page:395-400 CAOD TOC Alerts Note Thank you for choosing CAOD Table of Contents (TOC) Alert Service. You are receiving this email because you have requested to receive information from CAOD as a registered user of our Table of Content Alert for journals. To manage your TOC Alerts, please click here. For all enquiries, problems or suggestions regarding this service, please contact info@oriprobe.com. China/Asia on Demand (CAOD) Customer Service

Scholar : Journal of Otology, Year 2017, Issue 01 -New Issue Alert.

New Issue TOC Alert Dear Valued Customer, We are pleased to deliver your requested table of contents alert for Journal of Otology. Year 2017 Issue 01 is now available on CAOD. In this issue: Mitochondrial DNA mutations associated with aminoglycoside induced ototoxicity ...... page:1-8 Clinically relevant human temporal bone measurements using novel high-resolution cone-beam CT Jaakko L(a)helm(a), ,Antti Arnisalo, ,Ilmari Pyykk(o) ...... page:9-17 Suprathreshold compound action potential amplitude as a measure of auditory function in cochlear implant users Rachel A. Scheperle ...... page:18-28 Electrocochleographic recording in Asian adults:Preliminary normative data and demographic analyses Mohd Normani Zakaria, ,Nik Adilah Nik Othman, ,Zalilah Musa ...... page:29-33 Auditory deprivation modifies the expression of brain-derived neurotrophic factor and tropomyosin receptor kinase B in the rat auditory cortex Yuxing Wang, ,Ou Xu, ,Yanxing Liu, ,Hong Lu ...... page:34-40 A child with severe inner ear malformations with favorable hearing utilization and balance functions after wearing hearing aids Yusuke Kimura, ,Takeshi Masuda, ,Akifumi Tomizawa, ,Hideaki Sakata, ,Kimitaka Kaga ...... page:41-46 GUIDE FOR AUTHORS ...... page:47-52 CAOD TOC Alerts Note Thank you for choosing CAOD Table of Contents (TOC) Alert Service. You are receiving this email because you have requested to receive information from CAOD as a registered user of our Table of Content Alert for journals. To manage your TOC Alerts, please click here. For all enquiries, problems or suggestions regarding this service, please contact info@oriprobe.com. China/Asia on Demand (CAOD) Customer Service

Scholar : Chinese Journal of Otology, Year 2017, Issue 02 -New Issue Alert.

New Issue TOC Alert Dear Valued Customer, We are pleased to deliver your requested table of contents alert for Chinese Journal of Otology. Year 2017 Issue 02 is now available on CAOD. In this issue: zhong hua er ke xue za zhi gao yue (《中华耳科学杂志》稿约) ...... page:封3 Review Vlinical Application of Auditory Evoked Potentials (听觉诱发电位临床应用进展) JI Fei ...... page:138-146 Effects of EMG Rectification on Cervical and Ocular Vestibular Evoked Myogenic Potentials (EMG修正对颈部及眼部前庭诱发肌源性电位的影响) YU Lan, ,ZHAO Miaomiao, ,LI Qingxi, ,LIU Xingjian, ,ZUO Guohui, ,XIONG Fen, ,XIE Linzuo, ,LAN Lan, ,WANG Dayong, ,WU Ziming, ,JI Fei, ,ZHAO Lidong, ,WANG Qiuju ...... page:147-152 Relationship between Tone Pip ABR Thresholds and Pure Tone Thresholds in Normal Adults (听力正常成人短音ABR阈值与纯音听阈的关系研究) ZHOU NA, ,ZHAO Yanping, ,YAO Ziming, ,MA Furong ...... page:153-156 Clinical values of tone burst evoked cochlear microphonics in evaluating cochlear function (短纯音耳蜗微音电位评估耳蜗功能的临床应用价值) ZENG Fan-qian, ,Zheng Quan-yi, ,KE Zhaoyang ...... page:157-162 The consistency and relationship between behavioral auditory thresholds and ASSR thresholds using different stimulus in children with severe and profound sensorineural hearing loss (重度极重度聋儿童不同刺激声ASSR与行为测听听阈的一致性及相关性分析) AI Yu, ,LI Wenjing, ,XU Lei, ,FAN Zhaomin, ,WANG Haibo ...... page:163-167 Vestibular evoked myogenic potentials in patients with sudden deafness and vertigo (突聋伴眩晕患者前庭诱发肌源性电位的临床研究) XING Yingzi, ,PEI Jianjun, ,ZHAO Shu, ,LI Shujing, ,LIU Yajing, ,LI Liqun, ,HOU Qingjun, ,WANG Donghai, ,LU Hong ...... page:168-173 A Clinical Analysis of Auditory Brainstem Responses at High Stimulate Rate in Patients with OSAHS (阻塞性睡眠呼吸暂停低通气综合征患者的高刺激率ABR的临床分析) LI Xin, ,CHEN Wenjing, ,LIANG Sichao, ,GUO Zhenping, ,XU Jia, ,YI Haijin, ,YE Jingying, ,ZHAO Chunli, ,ZHANG Xiaoyan ...... page:174-179 Cochlear Implantation in CHARGE Syndrome (CHARGE综合征人工耳蜗植入) LI Wanxin, ,WANG Ning, ,HUANG Shasha, ,LI Beicheng, ,DAI Pu ...... page:180-184 Pathogenesis and audiologic performances in hidden hearing loss (隐性听力损失的发病机制及听力学表现) LI Guoqing, ,LV Ping, ,WANG Qiuju ...... page:185-190 Er Jing San in treating active chronic suppurative otitis media (中药耳净散治疗慢性化脓性中耳炎活动期的应用研究) GAI Jianqing, ,SUN Baoxia, ,AI Jianwei, ,ZHANG Hong, ,WANG Junge ...... page:191-194 Clinical and genetic features of a Chinese family with nonsydromic X-linked recessive hearing loss (非综合征型X连锁隐性遗传耳聋家系临床表型及遗传学特征分析) NIU Zhijie, ,FENG Yong, ,MEI Lingyun, ,SUN Jie, ,CHEN Hongsheng, ,HE Chufeng, ,LIU Yalan, ,WANG Xueping, ,WEN Jie, ,JIANG Zuo ...... page:195-200 Characteristics of ear fullness in patients with low frequency sudden deafness and their relationship (低频型突聋伴耳闷胀感患者耳闷胀感特征及与突聋的关系) Zhou En, ,Liu Bin, ,Zhao Peng, ,Huang Xueqiong, ,Yuan Minghao, ,Xiao Xuping ...... page:201-206 Evaluation of Early Cognitive Functions in Older Children and Teenager Recipients of Cochlear Implants (大龄儿童及青少年人工耳蜗植入后早期认知功能发展的评估) XU Liang, ,LIU Min, ,TANG Fengzhu, ,SHI Min, ,QU Shenhong, ,LIANG Jianping, ,LU Qiutian, ,Qin Ling, ,LI Dandan ...... page:207-212 Preliminary results of tinnitus severity inquiry using THI in outpatients over 55 years of age (55岁以上人群耳鸣严重程度门诊问卷初步结果分析) LIU Xinying, ,HAN Ying, ,ZHAO Suping ...... page:213-216 Effects of high level white noise exposure on hearing function in C57BL/6J Mice (120dB白噪声对C57BL/6J小鼠听力损失的观察研究) Wang Ding, ,Liu Ke, ,Zhang Yue, ,Yang Shiming, ,Ma Xiulan ...... page:217-221 Auditory Center injury after Focal Cerebral Ischemia-reperfusion Injury in RATS (大鼠局灶性脑缺血再灌注后听觉中枢损伤的研究) LV Zhe, ,ZHANG Ying, ,ZHANG Yubo, ,SHI Meijuan, ,MENG Qing, ,LU Hong ...... page:222-228 Epidemiological analysis of nonsyndromic hearing loss among 2,731 Uygur and Han patients in XinJiang (新疆维吾尔族及汉族常见耳聋基因热点突变调查结果分析比较) SUN Jie, ,CHEN Yu, ,ZHANG Hua, ,WEN Hao ...... page:229-233 Observation of developmental changes of hair cell synaptic ribbons in C57 mice (C57小鼠毛细胞突触带的发育观察) YANG Le, ,LIU Ke, ,YANG Shiming, ,GONG Pinggui, ,LIU Junyi, ,ZHNAG Junjun, ,WANG Xuemei, ,PENG Hong ...... page:234-238 Single nucleotide polymorphism in the development of human Genomics (单核苷酸多态性在人类基因组学发展中的应用) JIANG Yi, ,DAI Pu, ,HAN Dongyi ...... page:239-244 Sox10 Promotes Inner Ear Development (SOX10基因在内耳发育中的作用) HAO Qingqing, ,HOU Kun, ,ZHONG Lingling, ,REN Wei, ,GUO Weiwei, ,YANG Shiming ...... page:245-248 Lysosomal impairment and deafness (溶酶体异常与耳聋) ZHAO Weihao, ,YUAN Yongyi, ,HAN Weiju ...... page:249-256 Advances in Pathophysiological Studies of Cochlear Blood-Labyrinth Barrier (耳蜗血管纹血-迷路屏障病理生理学研究进展) ZHANG Tong, ,HAN Weiju ...... page:257-262 Importance of sequential treatment training in management of middle and outer ear congenital deformations (培养医生"序列治疗"理念对先天性中外耳畸形患者的重要意义) ZOU Yihui ...... page:263-266 Application of Three-dimensional Printing Technology In Individualized Auricle Reconstruction (3-D打印技术在个体化耳廓重建中的应用) TANG Ling, ,TIAN Guangyong, ,HU Lida, ,YANG Jingya, ,ZHANG Shanshan, ,LUO Heng ...... page:267-271 yan hou bu dai zhuang zuo zhen shou fa he bing hunt zong he zheng 1 li bing wen xian fu xi (咽喉部带状疱疹首发合并Hunt综合征1例并文献复习) LIU Yan, ,DING Feng ...... page:272-274 xuan yun fan fu fa zuo liang zhou (眩晕反复发作两周) SHEN Weidong, ,WANG Dayong, ,ZHANG Xinxin, ,WU Ziming, ,WANG Qiuju, ,YANG Shiming ...... page:275-279 er wai ke yi sheng de lin chuang si wei tan tao (耳外科医生的临床思维探讨Ⅱ) YU Lisheng ...... page:280-282 Basic and clinical electrophysiological researches on auditory pathway --Summary of the 1st Seminar 2017 Beijing-Tianjin-Hebei Pediatric Audiology Centers (听觉传导通路的基础及临床电生理研究——京津冀儿童听力诊断中心2017年第一季度学术研讨会) WANG Yu, ,DU Yali, ,ZHANG Zuo, ,PAN Tao, ,MA Zuorong ...... page:283-284 CAOD TOC Alerts Note Thank you for choosing CAOD Table of Contents (TOC) Alert Service. 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