Journal Name: Journal of Pediatric Endocrinology and Metabolism
Issue: Ahead of print
https://ift.tt/2B4oVhI
Σάββατο 11 Αυγούστου 2018
A personal series of 100 children operated for Cushing’s disease (CD): optimizing minimally invasive diagnosis and transnasal surgery to achieve nearly 100% remission including reoperations
Tetrathiomolybdate, a copper chelator inhibited imiquimod-induced skin inflammation in mice
Publication date: Available online 11 August 2018
Source: Journal of Dermatological Science
Author(s): Peng-Yang Hsu, Hsu-Heng Yen, Tao-Hsiang Yang, Che-Chun Su
Abstract
Background
Copper is an essential metal for maintenance of many biological functions; however, excessive amount can induce inflammation and oxidative stress. Tetrathiomolybdate (TM) is a copper chelator for treatment of Wilson's disease, and decreased the severity of autoimmune arthritis in mice.
Objective
In this report, we evaluated the effects of TM in a mouse model for psoriasis.
Methods
Imiquimod-induced psoriasis murine model was used. We applied immunohistochemistry staining and ELISA to determine levels of cytokines in the inflamed skin, splenocytes, and draining lymph nodes. In addition, we used keratinocytes and splenocytes to test the inhibitory effects of TM on cytokine production and activation of transcription factors.
Results
Our results showed that TM significantly reduced cumulative scores, epidermis thickness, and ki-67 expression in the inflamed skin. In addition, TM decreased skin cytokine levels and systemic inflammation. Moreover, TM suppressed activation in keratinocytes and splenocytes with reduction in phosphorylation of Erk1/2 and STAT3.
Conclusion
These findings are strong evidence that TM can inhibit psoriasis in the model.
https://ift.tt/2MjT9S7
Uptake and accumulation of polycyclic aromatic hydrocarbons in the mangroves Avicennia marina and Rhizophora mucronata
Abstract
This study investigated the uptake and accumulation of polycyclic aromatic hydrocarbons (PAHs) in two mangrove species, Avicennia marina and Rhizophora mucronata. We tested the hypothesis that A. marina would absorb and accumulate more PAHs than R. mucronata. One-year old seedlings of both species were subjected to Bunker Fuel Oil 180 for 3 weeks, and the concentration of PAHs was analyzed by gas chromatography-mass spectrometry (GC/MS). The concentration of PAHs was significantly higher in A. marina than in R. mucronata. The major portion of the PAH pool was in roots (96% in A. marina, 98% in R. mucronata) compared to leaves. The dominant PAHs in roots of both species possessed two to three rings and included phenanthrene, anthracene, fluorene, and acenaphthene. In shoots, PAHs in A. marina included phenanthrene, chrysene, anthracene, acenaphthene, benzo[k+b]fluoranthene, pyrene, benzo[a] anthracene, and benzo[a] pyrene, while those in R. mucronata included phenanthrene, naphthalene, fluoranthene, fluorene, and acenaphthene. Phenanthrene was the dominant PAH in roots and shoots of both species. The greater susceptibility of A. marina appears to be due to its greater root length and specific root length, which permit more exposure to oil than R. mucronata. Other contributory factors include root anatomical characteristics such as larger air spaces, lower suberization of root epidermal cells, lower concentrations of polyphenols, tannins, lignin, and a less efficient antioxidative system. This study provides novel information on differences in the uptake and accumulation of PAHs in two contrasting mangrove species.
https://ift.tt/2vZi6Il
Altered topology of the functional speech production network in non-fluent/agrammatic variant of PPA
Publication date: Available online 11 August 2018
Source: Cortex
Author(s): M.L. Mandelli, E. Vilaplana, A.E. Welch, C. Watson, G. Battistella, J.A. Brown, K.L. Possin, H.I. Hubbard, Z.A. Miller, M.L. Henry, G.A. Marx, M.A. Santos-Santos, L.P. Bajorek, J. Fortea, A. Boxer, G. Rabinovici, S. Lee, J. Deleon, H.J. Rosen, B.L. Miller
Abstract
Non-fluent/agrammatic primary progressive aphasia (nfvPPA) is caused by neurodegeneration within the left fronto-insular speech and language production network (SPN). Graph theory is a branch of vmathematics that studies the network architecture (topology) by quantifying features based on its elements (nodes and connections). This approach has been recently applied to neuroimaging data to explore the complex architecture of the brain connectome, though few studies exploited this technique in PPA. Here, we used graph theory on functional MRI resting state data of a group of 20 nfvPPA patients and 20 matched controls to investigate topological changes in response to focal neurodegeneration. We hypothesized that changes in the network architecture would be specific to the affected SPN in nfvPPA, while preserved in the spared default mode network (DMN). Topological configuration was quantified by hubs' location and global network's metrics. Our findings showed a less efficiently wired and less optimally clustered SPN, while no changes were detected in the DMN. The SPN in the nfvPPA group showed a loss of hubs in the left fronto-parietal-temporal area and new critical nodes in the anterior left inferior-frontal and right frontal regions. Behaviorally, speech production score and rule violation errors correlated with the strength of functional connectivity of the left (lost) and right (new) regions respectively. This study shows that focal neurodegeneration within the SPN in nfvPPA is associated with network-specific topological alterations, with loss and gain of crucial hubs and decreased global efficiency that were better accounted for by functional rather than structural changes. These findings support the hypothesis of selective network vulnerability in nfvPPA and may offer biomarkers for future behavioral intervention.
https://ift.tt/2vXgxuF
Monogenic polyautoimmunity in primary immunodeficiency diseases
Publication date: Available online 11 August 2018
Source: Autoimmunity Reviews
Author(s): Gholamreza Azizi, Reza Yazdani, Wiliam Rae, Hassan Abolhassani, Manuel Rojas, Asghar Aghamohammadi, Juan-Manuel Anaya
Abstract
Primary immunodeficiency diseases (PIDs) consist of a large group of genetic disorders that affect distinct components of the immune system. PID patients are susceptible to infection and non-infectious complications, particularly autoimmunity. A specific group of monogenic PIDs are due to mutations in genes that are critical for the regulation of immunological tolerance and immune responses. This group of monogenic PIDs is at high risk of developing polyautoimmunity (i.e., the presence of more than one autoimmune disease in a single patient) because of their impaired immunity. In this review, we discuss the mechanisms of autoimmunity in PIDs and the characteristics of polyautoimmunity in the following PIDs: IPEX; monogenic IPEX-like syndrome; LRBA deficiency; CTLA4 deficiency; APECED; ALPS; and PKCδ deficiency.
https://ift.tt/2B2UIj5
The link between immunity, autoimmunity and endometriosis: a literature update
Publication date: Available online 11 August 2018
Source: Autoimmunity Reviews
Author(s): Tao Zhang, Caterina De Carolis, Man Gene Chi-Wai, Chi-Chiu Wang
Abstract
Endometriosis (EMS), an estrogen-dependent inflammatory disorder affects approximately 5–10% of the general female population of reproductive age and 20–90% of women with pelvic pain and infertility. Many immunological factors are known to contribute significantly to the pathogenesis and pathophysiology of EMS, and both chronic local inflammation and autoantibodies in EMS shares many similarities with autoimmune diseases (AD). However, the autoimmune etiology in EMS remains controversial, and its evidence on autoimmune basis may be limited. Here we aim to review the current understanding between autoimmunity and EMS to provide important knowledge to develop future potential immunomodulatory therapy for the treatment of EMS.
https://ift.tt/2P2n283
Negative-pressure wound therapy for management of chronic neuropathic noninfected diabetic foot ulcerations – short-term efficacy and long-term outcomes
Abstract
Purpose
Negative pressure wound therapy (NPWT) is an adjunct method used in the treatment of diabetic foot ulceration (DFU). Real world data on its effectiveness and safety is scarce. In this prospective observational study, we assessed the short-term efficacy, safety, and long-term outcomes of NPWT in patients with type 2 diabetes (T2DM) and neuropathic, noninfected DFUs.
Methods
Based on wound characteristics, mainly area (>1 vs. ≤1 cm2), 75 patients with DFUs treated in an outpatient clinic were assigned to NPWT (n = 53) or standard therapy (n = 22). Wound area reduction was evaluated after 8 ± 1 days. Long-term outcomes assessed included complete ulceration closure and recurrence rate.
Results
Patients assigned to NPWT were characterized by greater wound area (15.7 vs. 2.9 cm2). Reduction in wound area was found in both the NPWT (−1.1 cm2, −10.2%, p = 0.0001) and comparator group (−0.3 cm2, −18.0%, p = 0.0038). No serious adverse events related to NPWT were noted. Within 1 year, 55.1% (27/49) of DFUs were closed in the NPWT group and 73.7% (14/19) in the comparator group (p = 0.15). In the logistic regression, wound duration and smaller initial area, but not treatment mode, were associated with closure. One-year follow-up after DFU resolution revealed an ~30.0% recurrence rate in both groups (p = 0.88).
Conclusions
NPWT is a safe treatment for neuropathic, nonischemic, and noninfected DFU in patients with T2DM, although this observational study did not prove its effectiveness over standard therapy. Additionally, we report a high rate of both closure and recurrence of ulcers, the latter irrespective of initial ulcer area.
https://ift.tt/2OuhUIY
Paraneoplastic autoimmune multiorgan syndrome (PAMS): Beyond the single phenotype of paraneoplastic pemphigus
Publication date: Available online 11 August 2018
Source: Autoimmunity Reviews
Author(s): Kyle T. Amber, Manuel Valdebran, Sergei A. Grando
Abstract
Paraneoplastic autoimmune multiorgan syndrome (PAMS) is characterized by a heterogenous group of signs and symptoms including severe desquamative stomatitis, a polymorphous cutaneous eruption, humoral immunity against plakin proteins, contribution of cell-mediated autoimmunity and commonly a progressive respiratory failure. Autoantibodies in PAMS target a wide array of antigens including plakins, cadherins, alpha-2-macroglobulin like 1 (A2ML1), BP180, plakophilin-3, and several neuromuscular antigens. Originally described as paraneoplastic pemphigus in 1990 due to some of its clinical and immunologic similarities to classic pemphigus (pemphigus vulgaris and pemphigus foliaceus), PAMS is a multiorganopathy with several distinct features from these classic forms of pemphigus. Epidemiologically, PAMS is associated with underlying neoplasia and has a differing HLA-II allele predisposition compared to classic forms of pemphigus. Clinically, lesion morphology is polymorphous, and lesion distribution fundamentally differs from that seen in classic pemphigus. PAMS has a significantly higher mortality rate and a poorer response to treatments typically effective in pemphigus. Histologically, PAMS is characterized by the presence of interface dermatitis, vacuolar changes, and dyskeratotic keratinocytes which are not seen in classic pemphigus. PAMS demonstrates not only intercellular IgG as seen in classic pemphigus, but the presence of linear basement membrane zone deposition. Antibodies against desmoglein 3 (Dsg3) map to a broader array of epitopes than in pemphigus vulgaris and there is a higher prevalence of complement binding anti-Dsg3 IgG autoantibodies in PAMS. Autoantibodies can in rare cases be absent in the more cell-mediated form of PAMS. Considering these numerable differences, we review the entity of PAMS, and provide similarities and differences to classic forms of pemphigus.
https://ift.tt/2P1JAWP
Recommendations and barriers to vaccination in systemic lupus erythematosus
Publication date: Available online 11 August 2018
Source: Autoimmunity Reviews
Author(s): Megha Garg, Naaima Mufti, Tara Palmore, Sarfaraz Hasni
Abstract
Patients with Systemic Lupus Erythematosus (SLE) pose a unique dilemma pertaining to immunization against common pathogens. SLE patients are usually not immunized with vaccines based on the fear of either precipitating infection in this immunosuppressed patient population (with live vaccines) or aggravating autoimmunity and hence lupus flares (with any vaccines). However, elevated vulnerability to infection makes patients with SLE precisely the population that needs protection from vaccine-preventable diseases. A summary of guidelines from the Centers for Disease Control and Prevention, professional societies, review articles and expert opinions regarding use of individual vaccines applicable to adults with SLE is presented in this review.
https://ift.tt/2KK14nc
Increased risk of thrombosis in antiphospholipid syndrome patients treated with direct oral anticoagulants. Results from an international patient-level data meta-analysis
Publication date: Available online 11 August 2018
Source: Autoimmunity Reviews
Author(s): Virginie DUFROST, Jessie RISSE, Tatiana RESHETNYAK, Maria SATYBALDYEVA, D.U. Yao, Xin-xin YAN, Stella SALTA, Grigorios GEROTZIAFAS, Zhi-Cheng JING, Ismaël ELALAMY, Denis WAHL, Stéphane ZUILY
Abstract
Background: Direct oral anticoagulants (DOACs) are widely used for secondary prevention of venous thromboembolism (VTE) but their clinical efficacy and safety are not established in Antiphospholipid Syndrome (APS) patients. There is only one randomized controlled trial published while others are still ongoing. Many non-randomized studies have been published in this field with conflicting opinions.
Purpose of review: We conducted a systematic review using MEDLINE, EMBASE and Cochrane databases from 2000 until March 2018 regarding APS patients treated with DOACs. We performed a patient-level data meta-analysis to a) estimate the prevalence of recurrent thrombosis in APS patients treated with DOACs in the literature, and b) identify variables associated with recurrent thrombosis.
Results: We identified 47 studies corresponding to 447 APS patients treated with DOACs. Three commercially available DOACs were analyzed: rivaroxaban (n = 290), dabigatran etexilate (n = 144) and apixaban (n = 13). A total of 73 out of 447 patients (16%) experienced a recurrent thrombosis while on DOACs with a mean duration until thrombosis of 12.5 months. Rates of recurrent thromboses were 16.9% and 15% in APS patients receiving either anti-Xa inhibitors or dabigatran respectively. Triple positivity (positivity for all three antiphospholipid antibodies) was associated with a four-fold increased risk of recurrent thrombosis (56% vs 23%; OR = 4.3 [95%CI; 2.3–7.7], p < .0001) as well as a higher number of clinical criteria for APS classification. In patients treated with anti-Xa inhibitors, history of arterial thrombosis was associated with a higher risk of recurrent thrombosis (32% vs 14%; OR = 2.8 [95%CI; 1.4–5.7], p = .006).
In conclusion, DOACs are not effective in all APS patients and should not be used routinely in these patients. Randomized controlled trials assessing clinical efficacy and safety as primary endpoints are underway. In the meantime, a registry of APS patients on DOACs could be proposed to establish in which APS subgroups DOACs would be a safe alternative to warfarin.
Graphical abstract
https://ift.tt/2OU8HL3
Negative-pressure wound therapy for management of chronic neuropathic noninfected diabetic foot ulcerations – short-term efficacy and long-term outcomes
Abstract
Purpose
Negative pressure wound therapy (NPWT) is an adjunct method used in the treatment of diabetic foot ulceration (DFU). Real world data on its effectiveness and safety is scarce. In this prospective observational study, we assessed the short-term efficacy, safety, and long-term outcomes of NPWT in patients with type 2 diabetes (T2DM) and neuropathic, noninfected DFUs.
Methods
Based on wound characteristics, mainly area (>1 vs. ≤1 cm2), 75 patients with DFUs treated in an outpatient clinic were assigned to NPWT (n = 53) or standard therapy (n = 22). Wound area reduction was evaluated after 8 ± 1 days. Long-term outcomes assessed included complete ulceration closure and recurrence rate.
Results
Patients assigned to NPWT were characterized by greater wound area (15.7 vs. 2.9 cm2). Reduction in wound area was found in both the NPWT (−1.1 cm2, −10.2%, p = 0.0001) and comparator group (−0.3 cm2, −18.0%, p = 0.0038). No serious adverse events related to NPWT were noted. Within 1 year, 55.1% (27/49) of DFUs were closed in the NPWT group and 73.7% (14/19) in the comparator group (p = 0.15). In the logistic regression, wound duration and smaller initial area, but not treatment mode, were associated with closure. One-year follow-up after DFU resolution revealed an ~30.0% recurrence rate in both groups (p = 0.88).
Conclusions
NPWT is a safe treatment for neuropathic, nonischemic, and noninfected DFU in patients with T2DM, although this observational study did not prove its effectiveness over standard therapy. Additionally, we report a high rate of both closure and recurrence of ulcers, the latter irrespective of initial ulcer area.
https://ift.tt/2OuhUIY
Scholar : Autophagy, Volume 14, Issue 7, 2018 is now available online on Taylor & Francis Online
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Scholar : ΓΛΩΣΣΙΤΙΣ - νέα αποτελέσματα
[HTML] Significantly higher frequencies of anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody positivity in atrophic glossitis …
CP Chiang, JYF Chang, YP Wang, YC Wu, YH Wu… - Journal of the Formosan …, 2018
Background/Purpose Atrophic glossitis (AG) patients are prone to have anemia,
hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell
antibody (GPCA) positivity. This study evaluated whether 1064 AG patients had …
hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell
antibody (GPCA) positivity. This study evaluated whether 1064 AG patients had …
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[PDF] PREVALENCE OF ORAL MUCOSAL LESIONS IN NONORAL HABIT DIABETIC PATIENTS AND NORMAL SUBJECTS
ZA Bhat, AH Chalkoo, R Hamid, S Tariq, DP Sharma - PARIPEX-INDIAN JOURNAL …, 2018
… Inflammatory such as gingivitis, periodontitis, candidiasis, stomatitis, benign
migratory glossitis or geographic tongue, median rhomboid glossitis and
angular cheilitis [5 9]. bacterial and fungal infections are more in diabetic …
migratory glossitis or geographic tongue, median rhomboid glossitis and
angular cheilitis [5 9]. bacterial and fungal infections are more in diabetic …
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[HTML] Oral lesions secondary to visceral leishmaniasis in a dog with endogenous hyperadrenocorticism: case report
MS Bochnakian, JAB Bezerra, K Fernandes, VR Barros… - Arquivo Brasileiro de …, 2018
… [ Links ]. FOGLIA MANZILLO, V.; PAGANO, A.; PACIELLO, O. et al.
Papular-like glossitis in a dog with leishmaniosis. Vet. Rec., v.156,
p.213-215, 2005. [ Links ]. LAMOTHE, J.; POUJADE, A. Ulcerative glossitis …
Papular-like glossitis in a dog with leishmaniosis. Vet. Rec., v.156,
p.213-215, 2005. [ Links ]. LAMOTHE, J.; POUJADE, A. Ulcerative glossitis …
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Review of Liver Disease and Perioperative Management in Dentistry
H Ephros, IL Garibyan - Hemostasis in Dentistry, 2018
… Also, glossitis may be seen in patients with alcoholic hepatitis [8] and alcohol-related
nutritional deficiencies (see Figs. 6.1 and 6.2) … 6.1. Fig. 6.1 Tongue of chronic alcoholic.
Open image in new window Fig. 6.2. Fig. 6.2 Glossitis from nutritional deficiencies …
nutritional deficiencies (see Figs. 6.1 and 6.2) … 6.1. Fig. 6.1 Tongue of chronic alcoholic.
Open image in new window Fig. 6.2. Fig. 6.2 Glossitis from nutritional deficiencies …
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[PDF] Anemia and associated factors in women at reproductive age in a Brazilian Northeastern municipality
AGN BezerraI, VS LealII, PIC de LiraIII, JS OliveiraII… - Rev BRas epidemiol, 2018
… Due to the reduced concentration of blood hemoglobin, the transport of
oxygen to the body tissues is compromised, causing changes in the aspect
of the skin and mucosa, with consequent paleness, glossitis, fatigue …
oxygen to the body tissues is compromised, causing changes in the aspect
of the skin and mucosa, with consequent paleness, glossitis, fatigue …
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The vitamin epidemic: what is the evidence for harm or value?
M Kennedy - Internal Medicine Journal, 2018
… Riboflavin (vitamin B 2 ). Riboflavin exists in two active forms: flavin mononucleotide and
flavin adenine dinucleotide, and is a requirement for carbohydrate and lipid metabolism.
Dietary deficiency causes angular stomatitis, glossitis and dermatitis …
flavin adenine dinucleotide, and is a requirement for carbohydrate and lipid metabolism.
Dietary deficiency causes angular stomatitis, glossitis and dermatitis …
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[PDF] Sextuple tumors in head and neck area: evidence of field cancerization Running Title: Field cancerization and sextuple tumors
CB Nelem-Colturato, PM Cury, TM Pereira, IS Cosso…
… in right tonsillar pillar, diagnosed as SCC, which is the fifth malignant tumor. Forty-six
months after the diagnostic the first malignancy, patient developed symptomatic lesions
in base of tongue diagnosed as nonspecific chronic glossitis. The tissue Page 4. 4 …
months after the diagnostic the first malignancy, patient developed symptomatic lesions
in base of tongue diagnosed as nonspecific chronic glossitis. The tissue Page 4. 4 …
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[HTML] Featured Case: UR3 on UR2
DB Giddon
Close. Login. Create New Account. message boards. today's active topics today's
active cases browse categories my recent activity my messages my private groups
my marked threads. today's active images today's active polls …
active cases browse categories my recent activity my messages my private groups
my marked threads. today's active images today's active polls …
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Scholar : CPAP - νέα αποτελέσματα
Oxyhemoglobin Resaturation following Obstructive Breathing Events Mitigates Sleep Apnea-Induced Glucose Elevations
LV Pham, AR Schwartz, JC Jun - Frontiers in Endocrinology, 2018
… in glucose regulation and diabetes. We recently showed that CPAP withdrawal in
patients with moderate-severe OSA leads to dynamic within-night glucose elevations
in proportion to the severity of IH. In the present study, we …
patients with moderate-severe OSA leads to dynamic within-night glucose elevations
in proportion to the severity of IH. In the present study, we …
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Investigating the structure and function of HSV-1 tegument proteins: UL7 and UL51
D Owen - 2018
… An interaction between UL51 and the G-Box domain of the centriole protein CPAP was
identified by Y2H screen, and validated by immunoprecipitation from transfected cells
and in pull-down experiments using recombinant proteins purified from E. coli …
identified by Y2H screen, and validated by immunoprecipitation from transfected cells
and in pull-down experiments using recombinant proteins purified from E. coli …
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[HTML] Recent advances in anesthesia of the obese patient
JB Brodsky - F1000Research, 2018
… insufflation ventilatory exchange" (THRIVE). THRIVE combines the benefits of apneic
oxygenation with continuous positive airway pressure (CPAP) and gas exchange
through flow-dependent dead-space flushing. THRIVE using 70 …
oxygenation with continuous positive airway pressure (CPAP) and gas exchange
through flow-dependent dead-space flushing. THRIVE using 70 …
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Upper Airway Stimulation in Patients Who Have Undergone Unsuccessful Prior Palate Surgery: An Initial Evaluation
C Huntley, A Vasconcellos, K Doghramji, B Hofauer… - Otolaryngology–Head and …, 2018
Upper airway stimulation therapy (UAS) is a new option for treatment of obstructive sleep
apnea (OSA) in patients unable to tolerate continuous positive airway ...
apnea (OSA) in patients unable to tolerate continuous positive airway ...
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[PDF] Low-cost adjustable mandibular advancement device for obstructive sleep apnea
S Upadhyay, SV Singh, D Arya, P Chand, RD Singh - J Dent Sleep Med, 2018
… MADs dilate or open the airway by anterior positioning of the mandible
during sleep to relieve snoring and OSA.6 They are especially helpful to
patients intolerant to CPAP because of nasal stuffiness, dryness, and …
during sleep to relieve snoring and OSA.6 They are especially helpful to
patients intolerant to CPAP because of nasal stuffiness, dryness, and …
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Comparison of Patient-and Parent-Reported Quality of Life for Patients Treated for Persistent Obstructive Sleep Apnea
M Bergeron, AL Duggins, AP Cohen, SL Ishman - Otolaryngology–Head and Neck …, 2018
Objectives To evaluate the impact of the treatment of persistent pediatric obstructive sleep
apnea (OSA) on quality of life (QOL) with patient-reported outcomes...
apnea (OSA) on quality of life (QOL) with patient-reported outcomes...
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[PDF] Parameter identifiability of a respiratory mechanics model in an idealized preterm infant
LE Fix - arXiv preprint arXiv:1808.00998, 2018
… Our model is the first known attempt to represent these dynamics that account
for the physiol- ogy particular to premature infants, and depict the mitigating
effects of expiratory laryngeal braking (grunting) and continuous positive …
for the physiol- ogy particular to premature infants, and depict the mitigating
effects of expiratory laryngeal braking (grunting) and continuous positive …
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Beyond Resistant Hypertension: Relationship Between Refractory Hypertension and Obstructive Sleep Apnea
MA Martínez-García, C Navarro-Soriano, G Torres… - Hypertension, 2018
… when associated with RH, in which case the prevalence of OSA reaches
levels of 71% to 90%.11–14 The main pathophysi- ological pathway by which
OSA triggers an increase in BP is the sympathetic system activation.15–17 …
levels of 71% to 90%.11–14 The main pathophysi- ological pathway by which
OSA triggers an increase in BP is the sympathetic system activation.15–17 …
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Prediction of ROP Treatment and Evaluation of Screening Criteria in VLBW Infants–a Population Based Analysis
R Gerull, V Brauer, D Bassler, B Laubscher, RE Pfister… - Pediatric Research, 2018
… The final model contained the following 5 risk factors: GA, birth weight z-score, CPAP >
3 days, multiple birth and surfactant … All rights reserved. Page 7. supplemental oxygen,
CPAP and mechanical ventilation was measured as number of days …
3 days, multiple birth and surfactant … All rights reserved. Page 7. supplemental oxygen,
CPAP and mechanical ventilation was measured as number of days …
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Clinicopathological case: progressive somnolence and dementia in an accountant: when the shine rubs off the gold standard
T Soane, JM Schott, J Stone, C Smith, RJ Davenport - 2018
… He was diagnosed with sleep apnoea, and initially responded well to continuous positive
airway pressure (CPAP), but by mid-2015 was sleeping up to 20 hours/day … He was
diagnosed with obstructive sleep apnoea and initially responded well to CPAP …
airway pressure (CPAP), but by mid-2015 was sleeping up to 20 hours/day … He was
diagnosed with obstructive sleep apnoea and initially responded well to CPAP …
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Summary Insulinomas are rare neuroendocrine tumours that classically present with fasting hypoglycaemia. This case report discusses an un...
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