A survey of physician practices on the inpatient medical stabilization of patients with avoidant/restrictive food intake disorder

Abstract

Background

Avoidant/restrictive food intake disorder (ARFID) was added to the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition in 2013. ARFID can result in impaired growth and significant nutritional deficiency; individuals with ARFID may be so nutritionally compromised that they require medical stabilization in a hospital. Prior to the new diagnostic criteria, it is unclear how patients now diagnosed with ARFID may have been medically stabilized when hospitalized. Our study aim was to assess the inpatient medical management of adolescents with ARFID.

Methods

United States-based physician members of the Society for Adolescent Health and Medicine's Eating Disorder Special Interest Group's listserv or the National Eating Disorders Quality Improvement Collaborative were invited to participate in an anonymous survey regarding their practices of care for hospitalized patients with ARFID.

Results

Thirty-seven (44.6%) of 83 physicians completed the survey; 73.0% (n = 27) of respondents medically admitted patients with ARFID. Half of respondents who admitted did not use any protocol for refeeding; 55% of those with a protocol used an anorexia nervosa treatment protocol. Solid food and nasogastric feeds were most commonly used for nutritional rehabilitation. Few typically prescribed medications in the hospital during medical stabilization.

Conclusions

There is considerable variability of practice in the treatment of hospitalized patients with ARFID. An important next step is to test the efficacy of protocols for anorexia nervosa in treating ARFID patients.

https://ift.tt/2IeLVKN

Acute effects of photobiomodulation therapy (PBMT) combining laser diodes, light-emitting diodes, and magnetic field in exercise capacity assessed by 6MST in patients with COPD: a crossover, randomized, and triple-blinded clinical trial

Abstract

Chronic obstructive pulmonary disease (COPD) is characterized by dyspnea, as well as musculoskeletal and systemic manifestations. Photobiomodulation therapy (PBMT) with use of low-level laser therapy (LLLT) and/or light-emitting diode therapy (LEDT) is an electrophysical intervention that has been found to minimize or delay muscle fatigue. The aim of this study was to evaluate the acute effect of PBMT with combined use of lasers diodes, light-emitting diodes (LEDs), magnetic field on muscle performance, exercise tolerance, and metabolic variables during the 6-minute stepper test (6MST) in patients with COPD. Twenty-one patients with COPD (FEV₁ 46.3% predicted) completed the 6MST protocol over 2 weeks, with one session per week. PBMT/magnetic field or placebo (PL) was performed before each 6MST (17 sites on each lower limb, with a dose of 30 J per site, using a cluster of 12 diodes 4 × 905 nm super-pulsed laser diodes, 4 × 875 nm infrared LEDs, and 4 × 640 nm red LEDs; Multi Radiance Medical™, Solon, OH, USA). Patients were randomized into two groups before the test according to the treatment they would receive. Assessments were performed before the start of each protocol. The primary outcomes were oxygen uptake and number of steps, and the secondary outcome was perceived exertion (dyspnea and fatigue in the lower limbs). PBMT/magnetic field applied before 6MST significantly increased the number of steps during the cardiopulmonary exercise test when compared to the results with placebo (129.8 ± 10.6 vs 116.1 ± 11.5, p = 0.000). PBMT/magnetic field treatment also led to a lower score for the perception of breathlessness (3.0 [1.0–7.0] vs 4.0 [2.0–8.0], p = 0.000) and lower limb fatigue (2.0 [0.0–5.0] vs 4.0 [0.0–7.0], p = 0.001) compared to that with placebo treatment. This study showed that the combined application of PBMT and magnetic field increased the number of steps during the 6MST and decreased the sensation of dyspnea and lower limb fatigue in patients with COPD.

https://ift.tt/2xzYEDK

Eosinophilic Dermatosis of Myeloproliferative Disease in a Young Adult With Diffuse Large B-Cell Lymphoma

Abstract: Exaggerated insect bite reactions present as exuberant papular and vesiculobullous lesions in patients with hematologic malignant neoplasms. The most commonly reported hematological malignancy with exaggerated insect bite reactions is chronic lymphocytic leukemia. Other reported reactions have been seen in patients with mantle cell lymphoma. Clinical presentation may vary with many patients unaware of a previous insect bite. Therefore, the terms "exaggerated bite-like reaction" and "eosinophilic dermatosis of myeloproliferative disease" have been proposed. The lesions may wax and wane or persist for many years, and they seem to be unrelated to the underlying hematologic disorder course or therapy. In some circumstances, the lesions may actually precede the diagnosis of the hematological malignancy. In this study, we describe a case of "eosinophilic eruption of myeloproliferative disease" associated with diffuse large B-cell lymphoma in a young adult. To the best of our knowledge, this is the first case reported in association with diffuse large B-cell lymphoma. Correspondence: Katrin Kiavash, MD, Department of Pathology, Roger Williams Medical Center, Boston University, 14 Shadow Farm Way, Wakefield, RI 02879 (kiavashkatrin@yahoo.com). K. Kiavash and A. Jencks have equal contribution to this manuscript and both are considered as first authors. The authors declare no conflicts of interest. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

https://ift.tt/2OSdRqf

Cutaneous Mastocytosis With Predominant Infiltration of Promastocytes

Abstract: Mastocytosis is a heterogeneous group of disorders with a variable clinical course, ranging from indolent disease with normal life expectancy to highly aggressive disease. In the skin, mast cells may show a spindle-shape appearance or appear as round cells with wide, polygonal cytoplasm. In this study, we present a case series of 4 patients with cutaneous childhood-onset mastocytosis in whom skin mast cells showed striking nuclear pleomorphism with bilobed and multilobed nuclei. Such finding does not seem to represent a malignant phenotype of the disease in the skin, although the true biological significance and the potential prognostic impact remain to be determined. Correspondence: Nicole Knöpfel, MD, Department of Dermatology, Hospital Infantil Universitario Niño Jesús, C/Menéndez Pelayo, 65, Madrid 28009, Spain (e-mail: nicole.knopfel@gmail.com). The authors declare no conflicts of interest. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

https://ift.tt/2zsQPkL

Mucinous Metaplasia of the Vulva in Zoon Vulvitis and Lichen Sclerosus et Atrophicus. Description of 3 Additional Cases of a Rarely Reported Histopathologic Finding

Abstract: Mucinous metaplasia of the vulva (MMV) is a histopathologic finding that has been reported previously in only 3 patients and needs to be distinguished from vulvar extramammary Paget disease. We report 3 additional instances of MMV associated to Zoon vulvitis and vulvar lichen sclerosus et atrophicus. Histochemical and immunohistochemical studies were performed on biopsies from erythematous and erosive vulvar lesions of 3 women aged 64, 80 and 84 years, with features of Zoon vulvitis (2 cases) and lichen sclerosus et atrophicus (1 case). Mucin-containing epithelial cells were present on the uppermost layers of the squamous epithelium. On immunohistochemical study the metaplastic cells were positive for cytokeratin 7, epithelial membrane antigen and carcinoembryonic antigen, thus mimicking the phenotype of Paget disease. MMV is most likely related to chronic inflammation. Cytological and architectural features allow for distinction from Paget disease because the mucin-containing cells of mucinous metaplasia of the vulva lack atypia and are predominantly located on the most superficial layers of the surface epithelium. Correspondence: Carlos Santonja, MD, Anatomía Patológica, Hospital Universitario Fundación Jiménez Díaz, Avenida de los Reyes Católicos, 2, 28040 Madrid, Spain (e-mail: csantonja@fjd.es). The authors declare no conflicts of interest. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

https://ift.tt/2OPzDuR

Brooke–Spiegler Syndrome: Two Patients From a Turkish Family With Multiple Familial Trichoepithelioma

No abstract available

https://ift.tt/2zu23W3

Follicle and Sebaceous Gland Multinucleated Cells in Measles

Abstract: We report the case of a 32-year-old man with measles in which skin biopsy helped to establish a definitive diagnosis. Follicular involvement is a common histopathologic feature of measles. Multinucleated epidermal and follicular cells are distinctive findings. Correspondence: Jorge Magdaleno-Tapial, MD, Department of Dermatology, Hospital General Universitario de Valencia, Avenida Tres Creus, 2, 46014 Valencia, Spain (e-mail: jormagta@gmail.com). J. Magdaleno-Tapial wrote most of the original draft of the paper. C. Valenzuela-Oñate, M. Giacaman-von der Weth, and B. Ferrer-Guillén have participated in writing the paper. M. García-Legaz Martínez and P. Hernández-Bel have followed the patient. V. Alegre-de Miquel and Á. Martínez-Domenech have performed the histological study of the samples. V. Alegre-de Miquel has followed the patient and has reviewed the pertinent raw data on which conclusions of this study are based. All authors have read and approved the final version of the manuscript submitted. The authors declare no conflicts of interest. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

https://ift.tt/2OQggC2

Langerhans Cell Histiocytoma: A Benign Histiocytic Neoplasm of Diverse Lines of Terminal Differentiation

Abstract: Langerhans cell (LC) histiocytoma is a neonatal tumor that often consists of a single, ulcerated nodule. Systemic involvement is rare, and LC histiocytoma is considered to be a variant of congenital, self-healing LC histiocytosis (also referred to as Hashimoto–Pritzker disease). In view of its low prevalence, LC histiocytoma is not always diagnosed in a clinical examination and requires histological confirmation. Furthermore, the histological and molecular features of LC histiocytoma have not been well characterized. Here, we report on 6 cases of this rare disease and review the corresponding literature. LC histiocytoma differs from classical self-healing LC histiocytosis with regard to the pathological features; we found that LC histiocytoma was associated with massive infiltration by histiocytes of various sizes and shapes (although often large) throughout the dermis and the superficial subcutis. Epidermotropism was rare, mitotic figures were not inconspicuous, and necrotic or calcified areas were often present. Immunohistochemical assessment revealed a mixture of different types of histiocytes (with CD1a+ CD207+, CD1a+ CD207−, and CD1a− CD207− CD163+ cells). Genetic testing was performed in 5 cases; it revealed a BRAF mutation (p.V600E and p.485_490delinsF) in 2 cases, a HRAS mutation (p.T58I) in 1 case, a combination of 2 PTEN mutations in another case (p.I224M and p. R234W), and no mutations in the fifth case. All the lesions regressed spontaneously, and none recurred during follow-up. Correspondence: Sylvie Fraitag, MD (e-mail: Sylvie.fraitag@aphp.fr). The authors declare no conflicts of interest. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

https://ift.tt/2zu4QP7

Acute Appearance Concerns in Patients Undergoing Mohs Surgery: A Single-Institution Cross-Sectional Study

No abstract available

https://ift.tt/2NB0XR3

Eccrine Porocarcinoma: New Insights and a Systematic Review of the Literature

BACKGROUND Eccrine porocarcinoma (EPC) is a rare cutaneous neoplasm with high potential for morbidity and mortality. Due to its rarity, there is a paucity of data profiling diagnosis, work-up, and management. OBJECTIVE To consolidate reported information on demographics, diagnostics, clinical behavior, treatment modalities, and patient outcomes in EPC to provide a reference tool to optimize diagnosis and management. METHODS A comprehensive PubMed search was performed from 1963 to November 2017 using PRISMA guidelines. This yielded 155 articles detailing 206 cases of porocarcinoma. RESULTS Eccrine porocarcinoma most often presents in elderly patients on the head and neck or lower limbs. Metastatic disease at presentation is not uncommon (22%). Primary tumor location is significantly correlated with presence of metastasis (p = .038). The most common treatment is excision followed by Mohs micrographic surgery (MMS), although the outcomes after MMS were superior to those after surgical excision. CONCLUSION This systematic review of individual patient data reveals that all patients should have a histological diagnosis with imaging considered for high-risk cases. Primary tumor location should also be considered in diagnostic and therapeutic decision-making. Although wide local excision (WLE) is currently the first-line treatment, MMS is becoming increasingly used, with evidence indicating improved outcomes as compared to those seen with WLE.

https://ift.tt/2Q6rGlo

Prospective Multicenter Clinical Trial of a Temperature-Controlled Subcutaneous Microneedle Fractional Bipolar Radiofrequency System for the Treatment of Cellulite

BACKGROUND A bipolar fractional radiofrequency (RF) device was developed to generate cutaneous thermal injuries using a temperature-controlled microneedle electrode array. OBJECTIVE Evaluate safety and efficacy of a novel subcutaneous microneedle RF for treatment of posterolateral thigh cellulite. METHODS The study design was an institutional review board-approved multicenter clinical trial after a per-protocol analysis. Fifty subjects with Nurnberger–Muller Grade II or III cellulite were enrolled at 4 treatment centers and received 1 subcutaneous microneedle RF treatment (67°C/4-second duration). Efficacy was evaluated by blinded grading by 3 dermatologists using randomized, standardized photographs and investigator grading at baseline, 1-, 3-, and 6-month follow-up. As per the Food and Drug Administration, treatment success was defined by ≥1-point improvement on dimple number or severity of undulation irregularities scales by at least 2 of 3 blinded physicians. Study subjects' self-assessments and satisfaction questionnaires and procedural pain levels and adverse events were monitored. RESULTS Blinded physician evaluations revealed a procedural success rate of 93% at 6-month follow-up. Procedural pain level was 3.74 ± 1.96 on a 10-point scale. There were no adverse events. Seventy-five percent of subjects were satisfied with the results at 6-month follow-up. CONCLUSION The results indicate that subcutaneous microneedle RF treatment is safe and effective for long-term treatment of Type II and III cellulite in a single session.

https://ift.tt/2NDMRyv

Cold Panniculitis After Cryolipolysis Treatment of the Abdomen

No abstract available

https://ift.tt/2Q1ULya

Efficacy Using a Modified Technique for Tissue Stabilized-Guided Subcision for the Treatment of Mild-to-Moderate Cellulite of the Buttocks and Thighs

BACKGROUND Cellulite can be significantly improved using vacuum-assisted tissue stabilized-guided subcision (TS-GS). However, the treatment of shallow and linear cellulite has remained problematic. OBJECTIVE In this retrospective study, we describe a modified technique of vacuum-assisted TS-GS. The aim is to demonstrate that this new limited-release technique is an effective treatment for long ripples and interconnected shallow dimples, which are characteristic of mild-to-moderate cellulite. METHODS Patients with mild-to-moderate cellulite were treated with limited-release vacuum-assisted TS-GS. All subcisions were performed at the 6-mm depth and a minimum of 3 mm between each dimple. Using a 4-point scale, 2 raters graded cellulite improvement on evaluation of prephotographs and postphotographs. RESULTS A total of 23 female patients were included in this study. The pre- and post-treatment photographs were correctly identified in 22 of the 23 patients (95.6%). The average cellulite improvement was 2.9 of 4 for the buttocks and 2.8 of 4 for the posterior thighs. Global cellulite improvement was reported at 3.1 of 4. CONCLUSION The results demonstrate that modified, limited-release, vacuum-assisted TS-GS can be an effective and safe method for the treatment of long ripples and shallow dimples that are characteristics of mild-to-moderate cellulite.

https://ift.tt/2NHFUMD

Novel Fasciotomy Technique for the Keystone Flap

No abstract available

https://ift.tt/2Q1UviG

Adipose Stromal Vascular Fraction Gel Grafting: A New Method for Tissue Volumization and Rejuvenation

BACKGROUND The clinical outcomes of fat grafting vary and are technique-dependent. Stromal vascular fraction (SVF) gel is a novel, mechanically processed fat product with high concentrations of adipose tissue–derived stem cells and other SVF cells. This study evaluated the volumization and rejuvenation effects of SVF-gel. OBJECTIVE This study evaluated the volumization and rejuvenation effects of SVF-gel. METHODS This retrospective, single-center study included 126 patients who underwent SVF-gel grafting and 78 who underwent conventional lipoinjection for various indications from March 2015 to February 2017. Patient satisfaction and secondary surgery rates were evaluated. Samples of transferred SVF-gel were harvested and examined histologically. RESULTS All patients showed improvements in facial augmentation and contour. Patients in the SVF-gel group experienced mild postoperative swelling and a low secondary surgery rate (10.9%). Assessment of patient-rated satisfaction on a 5-point Likert scale found that 77.3% of patients in the SVF-gel group were satisfied (54.5%) or very satisfied (22.8%) with their outcomes. By comparison, 53.8% of patients who underwent conventional lipoinjection were satisfied (48.7%) or very satisfied (5.1%). Moreover, SVF-gel showed effective antiwrinkle and skin rejuvenation effects. Hematoxylin–eosin staining showed a normal adipose tissue structure in transferred SVF-gel. CONCLUSION Stromal vascular fraction gel is effective for both volumization and rejuvenation, and may be superior to conventional lipoinjection for facial recontouring.

https://ift.tt/2NG9rGo

Marginal Mandibular Injury After Treatment With Cryolipolysis

No abstract available

https://ift.tt/2Q6ufnl

Endovenous Thermal Ablation of Recurrent Varicose Veins due to Residual Great Saphenous Venous Insufficiency After Saphenous Venous Surgery: A Comparative Study

BACKGROUND Redo surgery for recurrent varicose veins of the great saphenous vein (GSV) is technically more challenging than the initial surgery. OBJECTIVE To compare 980 and 1,470-nm endovenous laser ablation (EVLA) and radiofrequency ablation (RFA) for the treatment of residual GSV insufficiency after saphenofemoral ligation ± stripping. MATERIALS AND METHODS Thirty-seven limbs in 29 patients with recurrent varicose veins were retrospectively evaluated. Patients were divided into 3 groups: 980-nm EVLA (group A), 1,470-nm EVLA (group B), and RFA (group C). Duplex ultrasonography, Venous Clinical Severity Score (VCSS), and adverse events were examined at intervals of 1 week, 1, 3, 6, and 12 months. RESULTS Complete closure was achieved in 35 (94.6%) limbs at 12 months. Venous Clinical Severity Score decrease in group C (3.6 ± 0.5) was significantly (p

https://ift.tt/2NFlW55

Retrospective Multistudy Analysis of Axillary Odor Reduction After Microwave Treatment

No abstract available

https://ift.tt/2Q5g9Ti

Efficacy of 1,550-nm Erbium-Glass Fractional Laser Treatment and Its Effect on the Expression of Insulin-Like Growth Factor 1 and Wnt/β-Catenin in Androgenetic Alopecia

BACKGROUND A new treatment for androgenetic alopecia (AGA) is a 1,550-nm erbium-glass (Er:Glass) fractional laser. The wound healing process associated with this treatment is believed to be due to the stimulation of hair regrowth. Both the Wingless-related integration site (Wnt) proteins and insulin-like growth factor 1 (IGF-1) are important molecules that promote new hair growth. OBJECTIVE The aim of this study was to evaluate the efficacy of 1,550-nm Er:Glass fractional laser treatment and determine the gene expression of IGF-1 and Wnt/β-catenin in patients with AGA. METHODS Twenty-three patients with AGA were enrolled. They received 12 treatments at 2-week intervals. A scalp biopsy was performed to evaluate mRNA levels of Wnt10A and IGF-1. Histopathologic samples were collected. RESULTS Significant increases in hair count and shaft diameter that occurred from Month 4 until the end of the study were observed. Histological results showed increases in the follicular unit, anagen hair count, and the anagen:telogen ratio. No up-regulation of Wnt10A and IGF-1 mRNA was observed. CONCLUSION The 1,550-nm Er:Glass fractional laser treatment can increase hair density and shaft diameter in patients with AGA. The mechanisms by which 1,550-nm Er:Glass laser treatment induces new hair growth may not be limited to Wnt10A/β-catenin or IGF-1 expression.

https://ift.tt/2NHVEzp

Reconstruction of Large Auricular and External Auditory Canal Defect With Novel Guiding Sutures Placed in a Spoke Wheel Pattern

No abstract available

https://ift.tt/2Q6udMf

The Safety and Efficacy of Treatment With a 1,927-nm Diode Laser With and Without Topical Hydroquinone for Facial Hyperpigmentation and Melasma in Darker Skin Types

BACKGROUND The nonablative, fractional, 1,927-nm diode laser is theoretically a safe and effective treatment for hyperpigmentation and melasma in darker skin and may potentiate topical cosmeceutical delivery. OBJECTIVE To evaluate the use of a nonablative, fractional, 1,927-nm diode laser with and without topical 2% hydroquinone (HQ) cream for moderate-to-severe facial hyperpigmentation in Fitzpatrick skin Types III–V. METHODS Forty adults underwent 4 laser treatments at 2-week intervals and were randomized to daily application of 2% HQ cream or moisturizer. Follow-ups were conducted 4 and 12 weeks after the final laser treatment. RESULTS Hydroquinone and moisturizer groups demonstrated Mottled Pigmentation Area and Severity Index improvements of approximately 50% at post-treatment Weeks 4 and 12. Blinded investigator–assessed hyperpigmentation and photodamage improved significantly for both the groups at post-treatment Weeks 4 and 12. Subject satisfaction improved significantly in both the groups by post-treatment Week 4. Although investigator-rated Global Aesthetic Improvement Scale scores were significantly better in the HQ group at post-treatment Week 12, satisfaction was higher among those using moisturizer. No adverse events were noted. CONCLUSION The nonablative, fractional, 1,927-nm diode laser produced significant improvement in hyperpigmentation in Fitzpatrick skin Types III–V by 4 weeks, with maintenance of results at 12 weeks after treatment even without HQ.

https://ift.tt/2NIA91v

Dog Ear Regression in Function of Skin Elasticity

No abstract available

https://ift.tt/2Q7iEUX

A Comparison Study of the Nonablative Fractional 1565-nm Er: glass and the Picosecond Fractional 1064/532-nm NdYAG Lasers in the Treatment of Striae Alba A Split Body Double-Blinded Trial

BACKGROUND Few effective treatments exist for striae alba, which are the mature stage of stretch marks. OBJECTIVE To evaluate the efficacy of the nonablative fractional 1,565-nm Erbium-glass (Er:glass) and the picosecond fractional 1,064/532-nm neodymium:yttrium-aluminum-garnet (Nd:YAG) lasers in the treatment of striae alba. MATERIALS AND METHODS Twenty subjects with striae alba on the bilateral abdomen were treated with either the nonablative fractional 1565-nm Er:glass or the picosecond fractional 1,064/532-nm Nd:YAG laser, with a total of 3 treatments 3 weeks apart. RESULTS A 31% (1.25/4) texture improvement was noted for both the fractional 1,565-nm Er:glass laser and the picosecond fractional 1,064/532-nm Nd:YAG laser. The degree of atrophy was improved by 30% (1.19/4) with the 1,565-nm Er:glass laser and 35% (1.38/4) with the picosecond 1,064/532-nm Nd:YAG laser. A 48% (1.9/4) subject overall assessment of improvement was noted with the fractional 1565-nm Er:glass laser and 45% (1.8/4) improvement with the picosecond fractional 1,064/532-nm Nd:YAG laser. There was no significant change in striae density with either laser. The picosecond laser was rated as less painful during all 3 sessions (p = .002) and had a shorter healing time (p = .035). The nonablative fractional 1,565-nm Er:glass and the picosecond fractional 1,064/532-nm Nd:YAG lasers were equally efficacious in improving striae alba.

https://ift.tt/2NFj6x5

Pemphigus Foliaceus Demonstrating Pathergy After Mohs Micrographic Surgery

No abstract available

https://ift.tt/2Q4g6He

High-Fluence Light-Emitting Diode–Generated Red Light Modulates the Transforming Growth Factor-Beta Pathway in Human Skin Fibroblasts

BACKGROUND Skin fibrosis is a significant medical problem with limited available treatment modalities. The key cellular characteristics include increased fibroblast proliferation, collagen production, and transforming growth factor-beta (TGF-B)/SMAD pathway signaling. The authors have previously shown that high-fluence light-emitting diode red light (HF-LED-RL) decreases cellular proliferation and collagen production. OBJECTIVE Herein, the authors investigate the ability of HF-LED-RL to modulate the TGF-B/SMAD pathway. MATERIALS AND METHODS Normal human dermal fibroblasts were cultured and irradiated with a commercially available hand-held LED array. After irradiation, cell lysates were collected and levels of pSMAD2, TGF-Beta 1, and TGF-Beta I receptor were measured using Western blot. RESULTS High-fluence light-emitting diode red light decreased TGF-Beta 1 ligand (TGF-B1) levels after irradiation. 320 J/cm2 HF-LED-RL resulted in 59% TGF-B1 and 640 J/cm2 HF-LED-RL resulted in 54% TGF-B1, relative to controls. 640 J/cm2 HF-LED-RL resulted in 62% pSMAD2 0 hours after irradiation, 65% pSMAD2 2 hours after irradiation, and 95% 4 hours after irradiation, compared with matched controls. High-fluence light-emitting diode red light resulted in no significant difference in transforming growth factor-beta receptor I levels compared with matched controls. CONCLUSION Skin fibrosis is a significant medical problem with limited available treatment modalities. Light-emitting diode–generated red light is a safe, economic, and noninvasive modality that has a body of in vitro evidence supporting the reduction of key cellular characteristics associated with skin fibrosis.

https://ift.tt/2NFD7DQ

Successful Hair Transplantation for Scarring Alopecia Associated With Incontinentia Pigmenti

No abstract available

https://ift.tt/2Q6VhuV

Hidradenitis Suppurativa After Radical Surgery—Long-Term Follow-up for Recurrences and Associated Factors

BACKGROUND Hidradenitis suppurativa (HS) is a chronic debilitating skin disease in inverse body areas. Wide excision is recommended in Hurley Stages II to III, but the rate and symptoms of recurrences in long-term follow-up remain unclear. OBJECTIVE To analyze the allocation of recurrences regarding the operative field, the onset and quality of HS symptoms as well as factors associated with recurrences in long-term follow-up. MATERIAL AND METHODS Forty-eight patients with Hurley Stage III disease who had undergone 91 wide excisions from 2010 to 2015 were clinically examined regarding postoperative complications and allocation and quality of recurrences. To determine the risk of recurrence, possible surgery, and lifestyle-related associated factors were investigated. RESULTS Postoperative recurrences of HS were seen in 54.2%. Most recurrences (inflamed nodules) were detected in a

https://ift.tt/2NDgNKV

A Port-Wine Stain Treated With Pulsed Dye Laser: A Complication From Contaminated Makeup

No abstract available

https://ift.tt/2Q7iCwj

Comparing SLNE With or Without Preoperative Hybrid SPECT/CT in Melanoma

Condition:   Melanoma
Interventions:   Procedure: SLNE with preoperative hybrid SPECT/CT;   Procedure: Standard SLNE
Sponsor:   University Hospital, Essen
Not yet recruiting

https://ift.tt/2N3M44C

Fulminant Intracranial Hypertension Managed With Temporary Lumbar Drain

No abstract available

https://ift.tt/2QXUCwX

Anticancer Agent‐Induced Life‐Threatening Skin Toxicities: A Database Study of Spontaneous Reporting Data

AbstractStevens‐Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are potentially life‐threatening cutaneous and mucosal adverse reactions to drugs. Nevertheless, the connection to anticancer agents remains unclear. To provide insight into the association of such adverse reactions with anticancer agents, we analyzed the profile of anticancer agent‐induced SJS and TEN in the Japanese population. Of the 9,738 SJS/TEN events recorded in a database of spontaneous reporting data, 485 (5%, further categorized as SJS, 384 events, 79%; TEN, 101 events, 21%) were identified as anticancer agent‐induced, and 53 of these (11%) were fatal. Multivariate logistic regression analyses indicated that, compared with patients using other drugs, those using anticancer drugs had lower incident risk of death (hazard ratio [HR], 0.592; p = .0006), longer median time to onset of SJS/TEN (18 vs. 11 days; p < .0001; multivariate Cox regression: HR, 0.66; p < .0001), and a higher likelihood of developing SJS/TEN later than 70 days after initiation of the suspected causal agent (15% vs. 7%; p < .0001), highlighting the need for vigilance and continuous monitoring for SJS/TEN in patients treated with anticancer agents.Implications for Practice.Life‐threatening skin toxicities induced by anti‐cancer agents indicated significantly lower incident risk of death and longer time to onset of symptoms than for those induced by other drugs.

https://ift.tt/2IfdO5q

Perceptions of Oncologists About Sharing Clinic Notes with Patients

AbstractIn a large survey (n = 809) conducted to understand how oncologists differ from nononcologists regarding routinely sharing visit notes with patients, oncologists were less likely to agree patient safety would improve (p = .03) or that patients would be offended after reading notes (p = .01); however, they agreed with nononcologists that sharing notes would lead to less candid documentation (69% vs. 73%; p = .39). Oncologists share a high level of worry about the impact of sharing notes on documentation practices, a concern that will need to be addressed as the practice of sharing visit notes expands to cancer care.

https://ift.tt/2NBLcJu

A Phase II Trial of Pazopanib in Patients with Metastatic Alveolar Soft Part Sarcoma

Lessons Learned. Pazopanib shows a modest efficacy in metastatic alveolar soft part sarcoma.Clinical outcomes were comparable to those in previous studies using antiangiogenic drugs.Further prospective studies evaluating the benefit of pazopanib in alveolar soft part sarcoma with a larger sample are warranted to validate results.Background.Alveolar soft part sarcoma (ASPS) is a rare mesenchymal malignant tumor characterized by an unbalanced translocation, t(X;17)(p11.2;q25), which leads to the fusion of ASPSCR1 to the TFE3 transcription factor. Because this results in the upregulation of angiogenesis‐related transcripts, antiangiogenic drugs have been used in ASPS patients.Methods.This open‐label, single‐arm, multicenter, investigator‐initiated phase II trial was designed to evaluate efficacy and safety of pazopanib 800 mg once daily in patients with metastatic ASPS. The primary endpoint was investigator‐assessed overall response rate (ORR), and secondary endpoints were toxicity, progression‐free survival (PFS), and overall survival (OS). 68Ga‐RGD (Arg‐Gly‐Asp) positron emission tomography (PET) scan and gene expression profiling using NanoString platform were performed for biomarker analysis.Results.Six patients with histologically confirmed metastatic ASPS were enrolled between December 2013 and November 2014. Among six patients, one achieved a partial response (PR) (ORR 16.7%) and five patients showed stable disease (SD). With a median follow‐up of 33 months (range 18.7–39.3 months), median PFS was 5.5 months (95% confidence interval [CI] 3.4–7.6 months), and median OS was not reached. There were no severe toxicities except one patient with grade 3 diarrhea.Conclusion.Pazopanib showed modest antitumor activity with manageable toxicities for patients with metastatic ASPS.

https://ift.tt/2IejMUj

Response to Oral Immediate‐Release Opioids for Breakthrough Pain in Patients with Advanced Cancer with Adequately Controlled Background Pain

AbstractBackground.There is limited evidence about the response of breakthrough pain (BTP) to the most commonly used oral immediate‐release (IR) opioids. Our aim was to determine response rate to oral IR opioids for BTP control in patients with advanced cancer.Materials and Methods.In this prospective study, palliative care outpatients, with advanced cancer and adequately managed background pain, were asked to complete a self‐administered survey. We assessed patients' baseline demographics, pain characteristics, alcoholism (CAGE questionnaire), tobacco and substance abuse, and Edmonton Symptom Assessment Scores (ESAS). We determined the effectiveness of oral IR BTP opioids by using a 7‐point Likert scale ranging from "very ineffective" to "very effective." "Effective" and "very effective" were defined a priori as a good response to IR opioids for BTP.Results.Of 592 evaluable patients, 192 (32%) had background pain of ≤3 (ESAS pain scale 0–10). Among these 192 patients, 152 (79%) reported BTP, 143/152 (94%) took oral IR opioids for BTP, and 127/143 (89%) responded to a median dose of 10% of the total morphine equivalent daily dose. In univariate logistic regression analysis, younger age (odds ratio [OR], 0.94 per year; p = .008), higher ESAS scores for pain (OR, 1.32; p = .012), anxiety (OR, 1.24; p = .017), and dyspnea (OR, 1.31; p = .007) had statistically significant association with poor response to IR opioids for BTP. In multicovariate logistic regression, adjusted for age, a higher ESAS dyspnea score was significantly associated with poor response to oral IR opioids (OR, 1.44; p = .002).Conclusion.The vast majority of patients with advanced cancer with adequately controlled background pain reported a good response to oral IR opioids for BTP, supporting their use in clinical practice.Implications for Practice.Oral immediate‐release opioids are standard treatment for cancer breakthrough pain. However, information regarding treatment response to these commonly used opioids is limited. This study provides information that the vast majority of patients with advanced cancer, with adequately controlled background pain, reported good response to oral immediate release opioids for managing their breakthrough pain episodes. Results of this study support the use of conventional oral immediate release opioids that are relatively inexpensive and readily available for management of breakthrough pain in patients with advanced cancer.

https://ift.tt/2ND7Wcn

Landmark-based midsagittal plane analysis in patients with facial symmetry and asymmetry based on CBCT analysis tomography

Abstract

Purpose

Reconstruction of the facial midplane is relevant in anthropometry, orthodontics, maxillofacial surgery, and the accurate measurement of symmetry deviation is relevant in many fields of medicine especially when planning surgical treatment. In the literature, three different means of midplane generation have been published; however, there is currently no consensus regarding the approach to use. Morphometric methods are used to determine the true midsagittal plane (MSP), but its use in clinical practice is difficult. A regression plane based on N‑ANS-PNS landmarks reportedly approximates the morphometric MSP. As these points are vulnerable, we investigated which combination of landmarks can be substituted in symmetric and asymmetric faces.

Patients and methods

Thirty symmetric and 30 asymmetric faces were analyzed on cone-beam computed tomography scans. A total of 50 regression planes were generated based on three unpaired landmarks and 35 regression planes were generated based the midpoints of paired landmarks. The Na-ANS-PNS plane was used as reference plane, and the mean angle between it and each generated MSP was calculated. The differences from the reference plane were compared by t‑test between the groups.

Results

In the symmetric group, 86% of angles deviated by <5° using unpaired points, whereby 74% of angles deviated by <5° for paired points. Between the two groups 50% of planes from midline points, and 77% of planes from paired points were significantly different. All planes deviated more in the asymmetric group.

Conclusions

The N‑ANS-PNS reference plane can be substituted with the following combinations: ANS-G-Ba, ANS-G-S, ANS-S-De, PNS-G-Ba, PNS-S-Ba, PNS-ANS-G, and PNS-N-Ba.

https://ift.tt/2pBszXY

Follow-up in children with non-obese and non-autoimmune subclinical hypothyroidism

Journal Name: Journal of Pediatric Endocrinology and Metabolism
Issue: Ahead of print


https://ift.tt/2pAQNl9

Cosmetics, Vol. 5, Pages 56: Hair Strengthening Evaluation of Anisotropic Osmolite Solutions (Inositol + Arginine): Cross-Talk between Dermal Papilla Fibroblast and Keratinocytes of the Outer Root Sheath Using a µHair Follicle 3D Model

Cosmetics, Vol. 5, Pages 56: Hair Strengthening Evaluation of Anisotropic Osmolite Solutions (Inositol + Arginine): Cross-Talk between Dermal Papilla Fibroblast and Keratinocytes of the Outer Root Sheath Using a µHair Follicle 3D Model

Cosmetics doi: 10.3390/cosmetics5040056

Authors: Gianni Baratto Elisa Caviola Marisa Meloni Nicola Lionetti Adriana Bonfigli Maurizio Sironi Stefano Pieraccini Marc Oliver Luisa Coderch Luigi Rigano

The hair follicle (HF) is a dynamic &ldquo;mini-organ&rdquo; which undergoes bi-continuous cycles of growth, destruction and rest. The molecular mechanisms underlying the HF cycle are complex yet not fully understood. Anyhow, it is clear that the epithelial&ndash;mesenchymal interactions, and in particular the cross-talk between dermal papilla fibroblast (DPF) and the keratinocytes of the outer root sheath (ORSK) play a pivotal role. Aim of this study is the evaluation of the biological activity of anisotropic osmolyte solutions on the HF cycle. As reported in recent studies, dermal papilla cells deeply modify their gene expression profile when cultured as monolayers, but their transcriptional pattern can be partially restored when they are cultured as 3-dimensional spheroids. This draws our attention to the discovery that the spatial distribution of cells in the growth medium is fundamental in order to produce a verisimilar model. Therefore, we used the hanging drop technology to produce a scaffold-free micro-tissue model applied to a DPF-ORSK co-culture in order to create a &micro;HF 3-dimensional model. As a result, this system was capable of evaluating the efficacy of the anisotropic osmolyte solutions on the progressive increase of the follicle turnover and &lsquo;health&rsquo;. Moreover, an in silico model was used in order to screen the most promising combination of osmolyte molecules. In vivo objective evaluations were finally carried out on volunteers having hair disorders.

https://ift.tt/2Q6cMLF

Landmark-based midsagittal plane analysis in patients with facial symmetry and asymmetry based on CBCT analysis tomography

Abstract

Purpose

Reconstruction of the facial midplane is relevant in anthropometry, orthodontics, maxillofacial surgery, and the accurate measurement of symmetry deviation is relevant in many fields of medicine especially when planning surgical treatment. In the literature, three different means of midplane generation have been published; however, there is currently no consensus regarding the approach to use. Morphometric methods are used to determine the true midsagittal plane (MSP), but its use in clinical practice is difficult. A regression plane based on N‑ANS-PNS landmarks reportedly approximates the morphometric MSP. As these points are vulnerable, we investigated which combination of landmarks can be substituted in symmetric and asymmetric faces.

Patients and methods

Thirty symmetric and 30 asymmetric faces were analyzed on cone-beam computed tomography scans. A total of 50 regression planes were generated based on three unpaired landmarks and 35 regression planes were generated based the midpoints of paired landmarks. The Na-ANS-PNS plane was used as reference plane, and the mean angle between it and each generated MSP was calculated. The differences from the reference plane were compared by t‑test between the groups.

Results

In the symmetric group, 86% of angles deviated by <5° using unpaired points, whereby 74% of angles deviated by <5° for paired points. Between the two groups 50% of planes from midline points, and 77% of planes from paired points were significantly different. All planes deviated more in the asymmetric group.

Conclusions

The N‑ANS-PNS reference plane can be substituted with the following combinations: ANS-G-Ba, ANS-G-S, ANS-S-De, PNS-G-Ba, PNS-S-Ba, PNS-ANS-G, and PNS-N-Ba.

https://ift.tt/2pBszXY

Differences in cytoarchitecture of Broca’s region between human, ape and macaque brains

Publication date: Available online 24 September 2018

Source: Cortex

Author(s): Nicola Palomero-Gallagher, Karl Zilles

Abstract

Areas 44 and 45 have been identified in non-human primates as homologs of the human Broca region. Distribution of large and smaller pyramids and the ventro-lateral localization in the posterior frontal lobe enable their identification in non-human primates. Since only humans hold the ability of language, it has been hypothesized that differences in microstructure may, together with other anatomical factors, e.g. white matter tract connectivity, volumes of cortical areas and their molecular differentiation, be responsible for the lack (non-human primates) or ability (humans) of language. We sought to identify microstructural differences, by quantitatively studying the cytoarchitecture of areas 44 and 45 using layer-specific grey level indices (volume proportion of neuropil and cell bodies) in serially sectioned and cell body stained human, bonobo, chimpanzee, gorilla, orangutan and Macaca fascicularis brains. The main results are the interspecies differences in neuropil volume relative to cell bodies in all layers of both areas which allows a grouping of the different species into three major groups: Homo sapiens has the largest, great apes a markedly lower, and macaque the lowest neuropil volume. This indicates considerably more space for local and interregional connectivity in human brains, which matches recent studies of fiber tracts and spacing of cortical minicolumns because increasing connectivity also requires more space for axons and dendrites in the neuropil. The evolutionary enlargement of neuropil is, therefore, a major structural difference between humans and non-human primates which may correspond to the underlying functional differences.

https://ift.tt/2pxWDDE

A Systematic Review of Evidence-Based Treatments for Prurigo Nodularis

Publication date: Available online 25 September 2018

Source: Journal of the American Academy of Dermatology

Author(s): Azam A. Qureshi, Laura E. Abate, Gil Yosipovitch, Adam J. Friedman

Abstract

Prurigo nodularis is a chronic dermatologic condition involving the development of multiple cutaneous nodules in the setting of intractable pruritus. Given emerging treatment options for this difficult-to-treat condition, a current review of therapeutics is needed. A systematic review was performed for clinical studies investigating prurigo nodularis treatment published from 1990 to present including at least 5 subjects. A total of 35 articles were assigned a level of evidence according to the Oxford Center for Evidence-based Medicine. All five studies investigating topical agents, including corticosteroids, calcineurin inhibitors, calcipotriol, and capsaicin, conveyed some beneficial effect with level of evidence 2b or higher. Six of eight reports investigating photo- and photochemotherapy achieved levels of evidence 2b or greater and showed good partial response rates. Thalidomide was studied by six reports providing evidence of good symptom response, but only two of which were rated level 2b or greater. Cyclosporine and methotrexate have demonstrated benefit in four combined studies, albeit with level four evidence. Pregabalin, amitriptyline, paroxetine, fluvoxamine, and neurokinin-1 receptor antagonists have demonstrated promising evidence in five level 2b studies. Higher-powered studies and additional randomized controlled trials are needed for evaluation of safe and efficacious systemic treatment options for prurigo nodularis.

https://ift.tt/2NAckZo

Scholar : Aging, Neuropsychology, and Cognition, Volume 25, Issue 6, November 2018 is now available online on Taylor & Francis Online

The online platform for Taylor & Francis Online content Aging, Neuropsychology, and Cognition, Volume 25, Issue 6, November 2018 is now available online on Taylor & Francis Online. This new issue contains the following articles: Articles Remembering – but not knowing – disturbs the relational bindings newly established in short-term/working memory: an age-group comparison Arnaud Boujut & David Clarys Pages: 783-802 | DOI: 10.1080/13825585.2017.1373740 Why do older adults have difficulty with semantic fluency? Jean K. Gordon, Megan Young & Carly Garcia Pages: 803-828 | DOI: 10.1080/13825585.2017.1374328 A computerized test for the assessment of mild cognitive impairment subtypes in sentence processing Sofia Segkouli, Ioannis Paliokas, Dimitrios Tzovaras, Ioulietta Lazarou, Charalampos Karagiannidis, Filippos Vlachos & Magda Tsolaki Pages: 829-851 | DOI: 10.1080/13825585.2017.1377679 Effects of age and type of picture on visuospatial working memory assessed with a computerized jigsaw-puzzle task Pilar Toril, José M. Reales, Julia Mayas & Soledad Ballesteros Pages: 852-873 | DOI: 10.1080/13825585.2017.1377680 Review Articles The relationship between autobiographical memory, cognition, and emotion in older adults: a review Yong-Chun Bahk & Kee-Hong Choi Pages: 874-892 | DOI: 10.1080/13825585.2017.1377681 Articles Conceptual elaboration versus direct lexical access in WAIS-similarities: differential effects of white-matter lesions and gray matter volumes Sven-Erik Fernaeus & Åke Hellström Pages: 893-903 | DOI: 10.1080/13825585.2017.1378310 The role of regional heterogeneity in age-related differences in functional hemispheric asymmetry: an fMRI study Jiamin Gladys Heng, Chiao-Yi Wu, Josephine Astrid Archer, Makoto Miyakoshi, Toshiharu Nakai & Shen-Hsing Annabel Chen Pages: 904-927 | DOI: 10.1080/13825585.2017.1385721 Are there age differences in attention to emotional images following a sad mood induction? Evidence from a free-viewing eye-tracking paradigm Calandra Speirs, Zorry Belchev, Amanda Fernandez, Stephanie Korol & Christopher Sears Pages: 928-957 | DOI: 10.1080/13825585.2017.1391168 Corrigenda Corrigendum Pages: i-i | DOI: 10.1080/13825585.2017.1384659 To update which email alerts you receive, manage your alerts within the My Account area. Unsubscribe from new content alerts for this journal (both new issue and latest article notifications) with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Using Advances in Skin Imaging Technology and Genomics for the Early Detection and Prevention of Melanoma

Dermatology

https://ift.tt/2xxufWL

Scholar : ΜΑΣΤΟΕΙΔΙΤΙΣ - νέα αποτελέσμ

[PDF] Pólipo y/o granuloma aural en niños. Estudio prospectivo en 75 casos

DPC Bernáldez, CR García, G Morales, LG Quantin… - Medicina Infantil, 2018

… Diagnóstico final: colesteatoma 39 pacientes, OMA con pólipo de Scheibe
o complicada con mastoiditis 16, OMC simple granulo- matosa 13, TBC 2,
HCL 2, otitis externa y celulitis en conducto au- ditivo externo 2 y granuloma …

Urgent Infections of the Head and Neck

MD Russell, MS Russell - Medical Clinics, 2018

… Fig. 3. Coalescent mastoiditis with soft tissue abscess. (A) In this axial CT
with contrast, bone window demonstrates loss of bony septations within the
mastoid cavity (closed arrow). (B) Soft tissue window demonstrates an …

[PDF] 64. Hypertrophic pachymeningitis-myeloperoxidase antineutrophil cytoplasmic antibody-associated vasculitis or human immunodeficiency virus-related disease?

P Agrawal, S Melath, H Penn - Rheumatology Advances in Practice, 2018

… algorithm. Both seropositivity for MPO-ANCA and one surrogate marker for GPA
(chronic sinusitis, otitis media, or mastoiditis for >3 months) were required for
classification as GPA in patients with MPO-ANCA-positive HP. Several …

Chronic Ear Disease

SD Emmett, J Kokesh, D Kaylie - Medical Clinics, 2018

Skip to Main Content …

Cerebral venous thrombosis: A case series and a neuroimaging review of the literature

D Diacinti, G Cartocci, C Colonnese - Journal of Clinical Neuroscience, 2018

… and coma are observed [6] in cases with extensive thrombosis or affection
of the deep venous system with bilateral thalamic involvement [7]. Some
local and systemic factors may favor a CVT as processes that alter the venous …

Stroke in pediatric bacterial meningitis: Population-based epidemiology

M Dunbar, H Shah, S Shinde, J Vayalumkal… - Pediatric Neurology, 2018

… Changes consistent with sinusitis, 1/16, 6.3%, 5/24, 20.8%, 0.37. ▒▒Changes
consistent with otitis, 5/16, 31.3%, 1/24, 4.2%, 0.029. ▒▒Changes consistent
with mastoiditis, 5/16, 31.3%, 2/24, 8.3%, 0.077. Course and treatment …

[PDF] Perbedaan Tumbuh Kembang dan Status Imunitas Bayi Usia 6-12 Bulan Berdasarkan Pemberian ASI di WILAYAh Kerja Puskesmas Perawatan Ngkeran Kabupaten …

MA Ara - 2018

Page 1. PERBEDAAN TUMBUH KEMBANG DAN STATUS IMUNITAS BAYI USIA 6-12
BULAN BERDASARKAN PEMBERIAN ASI DI WILAYAH KERJA PUSKESMAS
PERAWATAN NGKERAN KABUPATEN ACEH TENGGARA TAHUN 2017 TESIS Oleh …

[HTML] Efectos de las maniobras cervicales en el flujo arterial vertebral extracraneal en pacientes con insuficiencia vertebrobasilar

HH Sánchez, ME Rodríguez, OV Pérez, CP Casal…

 

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Scholar : ΣΤΟΜΑΤΙΤΙΣ - νέα αποτελέσματ

[HTML] … and tolerability of HIV-1 multiantigen pDNA vaccine given with IL-12 plasmid DNA via electroporation, boosted with a recombinant vesicular stomatitis virus HIV Gag …

ML Elizaga, SS Li, NK Kochar, GJ Wilson, MA Allen… - PloS one, 2018

Background The addition of plasmid cytokine adjuvants, electroporation, and live
attenuated viral vectors may further optimize immune responses to DNA vaccines in
heterologous prime-boost combinations. The objective of this study was to test the …

Effect of laser irradiation on aphthae pain management: A four different wavelengths comparison

R Jean-Paul, Z Meng, F Carlo, T Lixin, Z Zengyi… - Journal of Photochemistry …, 2018

… Highlights. • Recurrent Aphthous Stomatitis (RAS) is a painful oral condition
characterized by ulcerations. • There … Keywords. Recurrent Aphthous Stomatitis. Laser.
Laser biomodulation. Er:YAG laser. Diode laser. 1. Introduction. The …

[HTML] Towards a new set of classification criteria for PFAPA syndrome

F Vanoni, R Caorsi, S Aeby, M Cochard, J Antón… - Pediatric Rheumatology, 2018

… Diagnosis of Periodic Fever, Aphthous stomatitis, Pharyngitis and Cervical Adenitis (PFAPA)
syndrome is currently based on the modified Marshall's criteria, but no validated evidence
based classification criteria for PFAPA has been established so far … apthous stomatitis …

[HTML] Oral Manifestations in Patients with Psoriasis: A Cross-Sectional Study

A Ehsani, H Mortazavi, P Nourmohamadpure… - Journal of Skin and Stem …, 2018

… We observed nonspecific oral lesions in 48% of the patients including
fissured tongue (35%), angular cheilitis (13%), actinic cheilitis (11%),
geographic tongue (6%), fibroma (3%) and denture stomatitis (2%). The …

[PDF] Tekrarlayan Oral Aft ve Behçet Hastalarında Ortalama Trombosit Hacmi Değerlerinin Karşılaştırılması

DB ÖZKAYA, ÖS KÜÇÜK, N ONSUN - 2018

… Comparing Mean Platelet Volume Values in Patients with Recurrent Aphthous Stomatitis
and Patients with Behcet's Disease … In this study, we aimed to investigate MPV values in
patients with Behcet's disease, patients with recurrent aphthous stomatitis, and controls …

Characteristics of rVSV-ZEBOV production kinetics in HEK293 and Vero cells

S Kiesslich, A Kamen, JF Gélinas, R Gilbert - 2018

… Conference Dates. June 17-22, 2018. Abstract. The vesicular stomatitis virus (VSV) can
be used as an effective vaccine platform, inducing both cellular and humoral immunity.
Because VSV infections of humans are mostly asymptomatic …

Protein-Repellent and Antibacterial Effects of a Novel Polymethyl Methacrylate Resin

L Cao, X Xie, B Wang, MD Weir, TW Oates, HHK Xu… - Journal of Dentistry, 2018

… Abstract. Objectives. Heat-cured resins are commonly used in orthodontics; however,
there is a high incidence of caries, periodontal diseases and denture-induced
stomatitis. The objectives of this study were to: (1) develop a …

Zeolite-embedded silver extends antimicrobial activity of dental acrylics

S Malic, S Rai, J Redfern, J Pritchett, CM Liauw… - Colloids and Surfaces B …, 2018

… 14]. The Candida genus, and C. albicans in particular, plays a very important part
in biofilm formation and denture stomatitis, however, bacteria also coexist within
denture biofilms [9,[15], [16], [17], [18], [19], [20]]. Streptococcus …

Reducing risks with a serum-free medium for MRC-5 based vaccine production

AB Hachmann, AM Campbell, J Donato - 2018

… medium. We confirmed virus production with varicella zoster virus and vesicular
stomatitis virus (as an analog to rabies virus) and demonstrated titers that were up
to one log higher than classical medium control cultures. Taken …

[PDF] 57. Rheumatology at the interface of medicine: haemphagocytic lymphohistiocytosis/macrophage activation syndrome: an under-recognised syndrome in the acutely …

RD Sandler, SJ Carter, RS Tattersal - Rheumatology Advances in Practice, 2018

Introduction: Haemophagocytic lymphohistiocytosis (HLH) is a rare hyperinflammatory
syndrome, characterised by the inappropriate survival of histiocytes and cyt.

 

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