Reconstructing Discontinuous Facial Defects with Simultaneous Ulnar Perforator Free Flaps

Summary: Multiple, simultaneous skin cancers of the face are common. This is the first description of reconstructing discontinuous facial defects (i.e., separate sites of the face) with simultaneous ulnar perforator flaps. The distinct innovations of this multiple flap design are the ability to restrict the harvest site to one extremity, to obtain vein and arterial grafts from the same extremity, and to create multiple flaps with minimal hirsutism and bulk. We present a case of a 57-year-old male with multiple basal cell carcinomas who underwent wide local excisions of the right upper lip and cheek and of the left lower eyelid and infraorbital cheek. Two left-sided ulnar perforator free flaps were used for reconstruction with the outcome of normal oral competence and eyelid function. When faced with discontinuous facial defects, reconstruction with simultaneous ulnar perforator flaps is a useful option because of the advantages of matching the thinness and pliability of the resected skin, reducing the number of harvest sites and preventing the distortion and contraction that can be seen with local advancement flaps or skin grafts.

http://ift.tt/2pE57Ha

Typical and atypical presenting symptoms of breast cancer and their associations with diagnostic intervals: Evidence from a national audit of cancer diagnosis

Publication date: June 2017
Source:Cancer Epidemiology, Volume 48
Author(s): Minjoung Monica Koo, Christian von Wagner, Gary A. Abel, Sean McPhail, Greg P. Rubin, Georgios Lyratzopoulos
IntroductionMost symptomatic women with breast cancer have relatively short diagnostic intervals but a substantial minority experience prolonged journeys to diagnosis. Atypical presentations (with symptoms other than breast lump) may be responsible.MethodsWe examined the presenting symptoms of breast cancer in women using data from a national audit initiative (n=2316). Symptoms were categorised topographically. We investigated variation in the length of the patient interval (time from symptom onset to presentation) and the primary care interval (time from presentation to specialist referral) across symptom groups using descriptive analyses and quantile regression.ResultsA total of 56 presenting symptoms were described: breast lump was the most frequent (83%) followed by non-lump breast symptoms, (e.g. nipple abnormalities (7%) and breast pain (6%)); and non-breast symptoms (e.g. back pain (1%) and weight loss (0.3%)).Greater proportions of women with 'non-lump only' and 'both lump and non-lump' symptoms waited 90days or longer before seeking help compared to those with 'breast lump only' (15% and 20% vs. 7% respectively). Quantile regression indicated that the differences in the patient interval persisted after adjusting for age and ethnicity, but there was little variation in primary care interval for the majority of women.ConclusionsAbout 1 in 6 women with breast cancer present with a large spectrum of symptoms other than breast lump. Women who present with non-lump breast symptoms tend to delay seeking help. Further emphasis of breast symptoms other than breast lump in symptom awareness campaigns is warranted.



http://ift.tt/2qUWCJO

Bacterial Contamination of CT Equipment

Publication date: Available online 23 May 2017
Source:Academic Radiology
Author(s): Brett W. Carter




http://ift.tt/2q9OI2f

Accuracy of Cyst Versus Solid Diagnosis in the Breast Using Quantitative Transmission (QT) Ultrasound

Publication date: Available online 23 May 2017
Source:Academic Radiology
Author(s): Elaine Iuanow, Kathleen Smith, Nancy A. Obuchowski, Jennifer Bullen, John C. Klock
Rational and ObjectivesThis study aims to evaluate the diagnostic utility of breast imaging using transmission ultrasound. We present readers' accuracy in determining whether a breast lesion is a cyst versus a solid using transmission ultrasound as an adjunct to mammography.Materials and MethodsThis retrospective multi-reader, multi-case receiver operating characteristic study included 37 lesions seen on mammography and transmission ultrasound. Cyst cases were confirmed as cysts using their appearance on handheld ultrasound. Solid cases were confirmed as solids with pathology results. Fourteen readers performed blinded, randomized reads with mammography + quantitative transmission scan images, assigning both a confidence score (0–100) and a binary classification of cyst or solid. A 95% percentile bootstrap confidence interval (CI) was computed for the readers' mean receiver operating characteristic area, sensitivity, and specificity.ResultsUsing the readers' binary classification of cyst or solid lesions, the mean sensitivity and specificity were 0.933 [95% CI: 0.837, 0.995] and 0.858 [95% CI: 0.701, 0.985], respectively. When the readers' confidence scores were used to distinguish a cyst versus solid, the mean receiver operating characteristic area was 0.920 [95% CI: 0.827, 0.985].ConclusionsTransmission ultrasound can provide an accurate assessment of a cyst versus a solid lesion in the breast. Prospective clinical trials will further delineate the role of transmission ultrasound as an adjunct to mammography to increase specificity in breast evaluation.



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The Impact of Fatigue on Satisfaction of Search in Chest Radiography

Publication date: Available online 23 May 2017
Source:Academic Radiology
Author(s): Elizabeth A. Krupinski, Kevin S. Berbaum, Kevin M. Schartz, Robert T. Caldwell, Mark T. Madsen
Rationale and ObjectivesTo assess the nature of the satisfaction of search (SOS) effect in chest radiography when observers are fatigued; determine if we could replicate recent findings that have documented the nature of the SOS effect to be due to a threshold shift rather than a change in diagnostic accuracy as in earlier film-based studies.Materials and MethodsNearing or at the end of a clinical workday, 20 radiologists read 64 chest images twice, once with and once without the addition of a simulated pulmonary nodule. Half of the images had different types of "test" abnormalities. Decision thresholds were analyzed using the center of the range of false-positive (FP) and true-positive (TP) fractions associated with each receiver operating characteristic (ROC) point for reporting test abnormalities. Detection accuracy was assessed with ROC technique and inspection time was recorded.ResultsThe SOS effect was confirmed to be a reduction in willingness to respond (threshold shift). The center of the FP range was significantly reduced (FP = 0.10 without added nodules, FP = 0.05 with added nodules, F(1,18) = 19.85, P = 0.0003). The center of the TP range was significantly reduced (TP = 0.39 without added nodules, TP = 0.33 with added nodules, F(1,18) = 10.81, P = 0.004).ConclusionsThis study suggests that fatigue does not change the nature of the SOS effect, but rather may be additive with the SOS effect. SOS reduces both TP and FP responses, whereas fatigue reduces TPs more than FPs.



http://ift.tt/2q9vWrT

The pathogenesis of dermatomyositis

Summary

This review looks at the many different factors thought to play a role in idiopathic inflammatory myopathies (IIM), concentrating mainly on the dermatomyositis (DM) subtype. Subject areas addressed include looking at the different clinical features of IIM, paying particular attention to the skin manifestations. There is a discussion around investigations needed with their perceived value, followed by a description of the immunohistochemical findings of DM. This review goes on to address other attributing factors such as genetic associations with the different subtypes of IIM, and environmental factors including infections, ultraviolet radiation and vitamin D deficiency and drugs. Finally, the potential immunopathogenesis of DM is summarized, looking at T cells, B cells, autoantibodies, dendritic cells, cytokines and nonimmune-mediated endoplasmic reticulum stress.

http://ift.tt/2rPpnrl

Endocannabinoids modulate apoptosis in endometriosis and adenomyosis

Publication date: Available online 23 May 2017
Source:Acta Histochemica
Author(s): Elif Bilgic, Elif Guzel Meydanli, Sevil Kose, Makbule Cisel Aydin, Eda Karaismailoglu, Irem Akar, Alp Usubutun, Petek Korkusuz
Adenomyosis that is a form of endometriosis is the growth of ectopic endometrial tissue within the muscular wall of the uterus (myometrium), which may cause dysmenorrhea and infertility. Endocannabinoid mediated apoptotic mechanisms of endometriosis and adenomyosis are not known. We hypothesized that the down regulation of endocannabinoid receptors and/or alteration in their regulatory enzymes may have a direct role in the pathogenesis of endometriosis and adenomyosis through apoptosis. Endocannabinoid receptors CB1 and CB2, their synthesizing and catabolizing enzymes (FAAH, NAPE-PLD, DAGL, MAGL) and the apoptotic indexes were immunohistochemically assessed in endometriotic and adenomyotic tissues. Findings were compared to normal endometrium and myometrium. Endometrial adenocarcinoma (Ishikawa) and ovarian endometriosis cyst wall stromal (CRL-7566) cell lines were furthermore cultured with or without cannabinoid receptor agonists. The IC50 value for CB1 and CB2 receptor agonists was quantified. Cannabinoid agonists on cell death were investigated by Annexin-V/Propidium iodide labeling with flow cytometry. CB1 and CB2 receptor levels decreased in endometriotic and adenomyotic tissues compared to the control group (p=0,001 and p=0,001). FAAH, NAPE-PLD, MAGL and DAGL enzyme levels decreased in endometriotic and adenomyotic tissues compared to control (p=0,001, p=0,001, p=0,001 and p=0,002 respectively). Apoptotic cell indexes both in endometriotic and adenomyotic tissues also decreased significantly, compared to the control group (p=0,001 and p=0,001). CB1 and CB2 receptor agonist mediated dose dependent fast anti-proliferative and pro-apoptotic effects were detected in Ishikawa and ovarian endometriosis cyst wall stromal cell lines (CRL-7566). Endocannabinoids are suggested to increase apoptosis mechanisms in endometriosis and adenomyosis. CB1 and CB2 antagonists can be considered as potential medical therapeutic agents for endometriosis and adenomyosis.



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Cetuximab modified collagen scaffold directs neurogenesis of injury-activated endogenous neural stem cells for acute spinal cord injury repair

Publication date: August 2017
Source:Biomaterials, Volume 137
Author(s): Xing Li, Yannan Zhao, Shixiang Cheng, Sufang Han, Muya Shu, Bing Chen, Xuyi Chen, Fengwu Tang, Nuo Wang, Yue Tu, Bin Wang, Zhifeng Xiao, Sai Zhang, Jianwu Dai
Studies have shown that endogenous neural stem cells (NSCs) activated by spinal cord injury (SCI) primarily generate astrocytes to form glial scar. The NSCs do not differentiate into neurons because of the adverse microenvironment. In this study, we defined the activation timeline of endogenous NSCs in rats with severe SCI. These injury-activated NSCs then migrated into the lesion site. Cetuximab, an EGFR signaling antagonist, significantly increased neurogenesis in the lesion site. Meanwhile, implanting cetuximab modified linear ordered collagen scaffolds (LOCS) into SCI lesion sites in dogs resulted in neuronal regeneration, including neuronal differentiation, maturation, myelination, and synapse formation. The neuronal regeneration eventually led to a significant locomotion recovery. Furthermore, LOCS implantation could also greatly decrease chondroitin sulfate proteoglycan (CSPG) deposition at the lesion site. These findings suggest that endogenous neurogenesis following acute complete SCI is achievable in species ranging from rodents to large animals via functional scaffold implantation. LOCS-based Cetuximab delivery system has a promising therapeutic effect on activating endogenous neurogenesis, reducing CSPGs deposition and improving motor function recovery.



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Editorial board

Publication date: August 2017
Source:Biomaterials, Volume 136





http://ift.tt/2qUk1NH

3D full-field quantification of cell-induced large deformations in fibrillar biomaterials by combining non-rigid image registration with label-free second harmonic generation

Publication date: August 2017
Source:Biomaterials, Volume 136
Author(s): Alvaro Jorge-Peñas, Hannelore Bové, Kathleen Sanen, Marie-Mo Vaeyens, Christian Steuwe, Maarten Roeffaers, Marcel Ameloot, Hans Van Oosterwyck
To advance our current understanding of cell-matrix mechanics and its importance for biomaterials development, advanced three-dimensional (3D) measurement techniques are necessary. Cell-induced deformations of the surrounding matrix are commonly derived from the displacement of embedded fiducial markers, as part of traction force microscopy (TFM) procedures. However, these fluorescent markers may alter the mechanical properties of the matrix or can be taken up by the embedded cells, and therefore influence cellular behavior and fate. In addition, the currently developed methods for calculating cell-induced deformations are generally limited to relatively small deformations, with displacement magnitudes and strains typically of the order of a few microns and less than 10% respectively. Yet, large, complex deformation fields can be expected from cells exerting tractions in fibrillar biomaterials, like collagen. To circumvent these hurdles, we present a technique for the 3D full-field quantification of large cell-generated deformations in collagen, without the need of fiducial markers. We applied non-rigid, Free Form Deformation (FFD)-based image registration to compute full-field displacements induced by MRC-5 human lung fibroblasts in a collagen type I hydrogel by solely relying on second harmonic generation (SHG) from the collagen fibrils. By executing comparative experiments, we show that comparable displacement fields can be derived from both fibrils and fluorescent beads. SHG-based fibril imaging can circumvent all described disadvantages of using fiducial markers. This approach allows measuring 3D full-field deformations under large displacement (of the order of 10 μm) and strain regimes (up to 40%). As such, it holds great promise for the study of large cell-induced deformations as an inherent component of cell-biomaterial interactions and cell-mediated biomaterial remodeling.



http://ift.tt/2rSnutg

Scholar : These new articles for Archives of Agronomy and Soil Science are available online

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The online platform for Taylor & Francis Online content New for Archives of Agronomy and Soil Science and online now on Taylor & Francis Online: Original Articles Nutrient status of soil and winter wheat (Triticum aestivum L.) in response to long-term farmyard manure application under different climatic and soil physicochemical conditions in the Czech Republic Pavel Tlustoš, Michal Hejcman, Eva Kunzová, Lukáš Hlisnikovský, Hana Zámečníková & Jiřina Száková Pages: 1-14 | DOI: 10.1080/03650340.2017.1331297 Browse papers on image & data fusion, GIS, LiDAR & more in the International Journal of Image and Data Fusion's exclusive Editor's Choice collection. To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : These new articles for Research in Dance Education are available online

The online platform for Taylor & Francis Online content New for Research in Dance Education and online now on Taylor & Francis Online: Original Articles Gender differences in motivation for participation in extra-curricular dance: application of the Theory of Planned Behaviour Steven David Anderson, Sandra Darkings Leyland & Jonathan Ling Pages: 1-11 | DOI: 10.1080/14647893.2017.1330325 To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : These new articles for AIDS Care are available online

The online platform for Taylor & Francis Online content New for AIDS Care and online now on Taylor & Francis Online: Original Articles Provider perceptions on HIV risk and prevention services within permanent supportive housing Suzanne L. Wenzel, Benjamin Henwood, Taylor Harris, Hailey Winetrobe & Harmony Rhoades Pages: 1-5 | DOI: 10.1080/09540121.2017.1330533 Now available - Human Service Organizations: Management, Leadership & Governance BEST ARTICLES – click here. To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : Ειδοποίηση Μελετητή - [ CPAP ]

Ειδοποίηση Μελετητή:[ CPAP ]

Mild Intermittent Hypoxia with Sustained Hypercapnia Improves Airflow, Reduces Therapeutic CPAP and Blood Pressure in Participants with Obstructive Sleep Apnea

M El-Chami, S Sudan, T McCready, HS Lin, JH Mateika - The FASEB Journal, 2017

Abstract Intermittent hypoxia (IH) elicits long term facilitation of ventilation and upper airway
muscle activity. The latter form of plasticity could contribute to stabilizing the upper airway.
Based on this possibility, we examined if administration of mild IH accompanied by

[PDF] A case of obstructive sleep apnea syndrome associated with floppy eyelid syndrome: positive effect of CPAP therapy

R Porta, L Comini, L Barbano, L Bianchi, M Vitacca - Monaldi Archives for Chest …, 2017

Abstract The obstructive sleep apnoea syndrome (OSAS) may be associated with several
eyes disorders, among which the most common is the floppy eyelid syndrome (FES). We
intended to highlight the association between OSAS and FES and evaluate the effect of FES

Positional Complex Sleep Apnea: Not So Complex

KS Pawar, A Goyal, A Khurana - Sleep and Vigilance, 2017

... During titration part of split night, even at CPAP pres- sure of 4 cm H2O in supine position, patient
developed complex sleep apnea (Fig. 1); which was mainly seen in NREM stage (N1 and N2). ...
2). Patient did not settle with CPAP or Bi-level PAP (S/T) during first split night study. ...

Insomnia and Health-Related Quality of Life in Adults With Type 2 Diabetes

ER Chasens - Sigma Theta Tau International's 28th International …, 2017

... education. Inclusion criteria for the baseline assessment include age > 18 years;
self-report of T2DM, CPAP naïve, and willing to be randomized to CPAP if found
to have OSA (apnea + hypopnea index [AHI] ≥ 10). Measures ...

Fathers' experience of starting family life with an infant born prematurely due to mothers' severe illness

IE Værland, K Vevatne, BS Brinchmann - Sexual & Reproductive Healthcare, 2017

... 2, 33, 3, Secondary school, Bachelor's student, 24, Ventilator, CPAP. 3, 33, 2, Secondary school,
27, Ventilator, CPAP. 4, 44, 4, Two-year high school, 31.5, CPAP. 5, 33, 2, Three-year high school,
31, CPAP. 6, 28, 1, Secondary school, high school student, 31.1, CPAP. ...

Pilot Prospective Study of Post-Surgery Sleep and EEG Predictors of Post-Operative Delirium

JL Evans, JW Nadler, XA Preud'homme, E Fang… - Clinical Neurophysiology, 2017

... 2. Methods. This project was part of a larger study investigating whether continuous positive airway
pressure (CPAP) decreases post-hip/knee replacement surgery delirium in patients age≥50
at-risk for obstructive sleep apnea (STOP-BANG test score ≥3) (Chung et al., 2012). ...

[HTML] Emerging Nursing Roles in Collaborative Management of Sleep-Disordered Breathing and Obstructive Sleep Apnea (OSA)

K Harper - Sigma Theta Tau International's 28th International …, 2017

... Currently continuous positive airway pressure (CPAP) and variations such as nasal
CPAP, are the gold standard for management of diagnosed OSA especially in more
severe spectrum presentations. Due however to documented ...

[HTML] Using PaCO2 values to grade obesity-hypoventilation syndrome severity: a retrospective study

MF Damiani, VA Falcone, P Carratù, C Scoditti, E Bega… - Multidisciplinary Respiratory …, 2017

... OHS. CPAP responders rate significantly decreased from mild to severe OHS. ... All subjects
initially underwent continuous positive airway pressure (CPAP) titration, and the CPAP
adjustement was performed with manual titration. Patients ...

[HTML] Abnormal Thermal Patterns in Very Preterm Infants Associated With Infection and Maternal Smoking

RB Dail - Sigma Theta Tau International's 28th International …, 2017

... Infants also had a higher mean percentage of minutes with FT greater than AT while on CPAP
than infants had on days without CPAP (20.19% vs 15.91%, p< 0.06) in contrast to infants who
were intubated and on a ventilator had less mean percentage of minutes with FT greater ...

Regulation of Erythropoiesis after Normoxic Return from Chronic Sustained and Intermittent Hypoxia.

J Song, K Sundar, R Gangaraju, JT Prchal - Journal of Applied Physiology, 2017

... polycythemia, which was not attributable to other causes and corrected with continuous
positive 40 airway pressure therapy (CPAP) therapy. ... increased inflammatory markers.
After correction of OSA with use of CPAP for >3 months, 43 ...

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Scholar : Ειδοποίηση Μελετητή - [ ΛΟΓΟΣ

Ειδοποίηση Μελετητή:[ ΛΟΓΟΣ ]

Ανθρώπινο Δυναμικό και Αξιολόγηση στο Δημόσιο Τομέα. Η Περίπτωση του Ιδρύματος Κοινωνικών Ασφαλίσεων (ΙΚΑ).

Ε Καλαντζή - 2017

... Δημόσιο Τομέα καθώς για ορισμένες παροχές αποτελεί τον μοναδικό φορέα. Αυτός
είναι ένας σημαντικός λόγος για τον εκσυγχρονισμό του και την αναβάθμισή του. Η
εργασία αποτελείται ουσιαστικά από 3 μέρη: Το πρώτο μέρος ...

Ασφάλεια εικονικών δικτύων (VPN)

ΙΑΜ Γκολφόπουλος, ΧΑΜ Χαλκιόπουλος - 2017

... Στη συνέχεια, θα αναφερθούν τα πρώτα ιδιωτικά δίκτυα, το πρωτόκολλο ip, η τεχνολογία
mlps και οι αρχιτεκτονικές των εικονικών ιδιωτικών δικτύων. Έπειτα θα γίνει λόγος για
τον εικονικό κόσμο , την αρχιτεκτονική δικτύων και τη δομή τους. ...

Ηθική και Τραπεζικό σύστημα, Δύο εναλλακτικά" ηθικά" τραπεζικά συστήματα

Α Καρδάμης - 2017

... μεταρρυθμίσεις για να συνεχίσει να είναι βιώσιμο. Η έννοια της Εταιρικής Κοινωνικής
Ευθύνης ήρθε στο προσκήνιο και άρχισε να γίνεται λόγος για τραπεζική ηθική. Η
εμφάνιση εναλλακτικών τραπεζικών συστημάτων που στηρίζονται ...

Η συμβολή του μητρικού θηλασμού στον νεογνικό ίκτερο:'διάρκεια θεραπείας νεογνών που χρήζουν φωτοθεραπείας σε συνάρτηση με τον τρόπο σίτισης τους'

Ν Πογόσοβα, N Pogosova - 2017

... Ημερομηνία. 2017-05-18. Συγγραφέας. Πογόσοβα, Νάντια. Pogosova, Nantia. Μεταδεδομένα.
Εμφάνιση πλήρους εγγραφής. Επιτομή. Ο λόγος εκπόνησης αυτής της πτυχιακής είναι η
διερεύνηση της σχέσης του θηλασμού με την εμφάνιση του φυσιολογικού νεογνικού ίκτερου. ...

[PDF] RICORDARE LA GUERRA Cimiteri di guerra ed epitafi per i caduti nella Grecia antica

V GARULLI - TEATRI DI GUERRA

... V. Garulli-Ricordare la guerra 147 Ma, oltre alle parole scritte sulla pietra dei monumenti, altre
parole percorrevano il cimitero di guerra ateniese: quelle dell'ἐπιτάφιος λόγος, il discorso funebre
ufficiale pronunciato al Ceramico da un uomo politico scelto dai cittadini per ...

[PDF] Введення в ендокринологію

СА Біленький - 2017

... ВСЬОГО СУБКЛІНІЧНИЙ ЯВНИЙ Page 4. ЕНДОКРИНОЛОГІЯ (від грец. ἔνδον – всередину,
κρίνω – виділяю і λόγος – наука) наука про будову та функції залоз внутрішньої секреції
(ендокринних залоз), про продукти (гормони), які виробляються ними (їх струк- ...

[PDF] Eine kleine Genealogie des Verhältnisses von Anthropologie und Ontologie im Denken Adornos mit einem Seitenblick auf Ulrich Sonnemann

S Edinger - 2017

... ontische Seinsregion. Und von Ontologie ist insofern die Rede, als von diesem ὄν
der λόγος gewonnen werden soll». Page 3. 257 Eine kleine Genealogie des
Verhältnisses von Anthropologie und Ontologie diese Transformation ...

[PDF] A Psychological and Philosophical Understanding of Death: An Analysis of Platonic and Epicurean Philosophy in Modern America

A Hupp - 2017

Page 1. Xavier University Exhibit Honors Bachelor of Arts Undergraduate 2017-3 A Psychological
and Philosophical Understanding of Death: An Analysis of Platonic and Epicurean Philosophy
in Modern America Alexina Hupp Xavier University, Cincinnati, OH ...

[PDF] Η καινοτομική δραστηριότητα των μικρομεσαίων επιχειρήσεων. Η περίπτωση της Κρήτης.

I Leukaditi, Η Λευκαδίτη, Ι Μπιλιλή, I Bilili - 2017

... άρρηκτα συνδεδεμένη με την αβεβαιότητα και το ρίσκο για το νέο προϊόν. Ο βασικότερος δε λόγος
για την υιοθέτηση αυτής από τις επιχειρήσεις είναι η δημιουργία συγκριτικού πλεονεκτήματος.
Μάλιστα, η ανάγκη αυτή είναι ακόμη μεγαλύτερη για τις νέες επιχειρήσεις οι ...

[PDF] Μελέτη και εγκατάσταση συστήματος συναγερμού στην αίθουσα Β111

Ε Λουκάς, Ι Σκιαδάς - 2017

... Η δεύτερη σειρήνα είναι τοποθετημένη στον εσωτερικό χώρο τις αίθουσας. Ο λόγος ύπαρξης της
εσωτερικής σειρήνας είναι καθαρά για την δημιουργία πανικού του εισβολέα. Η συχνότητα που
εκπέμπει είναι επιστημονικά αποδεδειγμένο ότι αποσυντονίζει την σκέψη του ...

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