Diadenosine-Polyphosphate Analogue AppCH2ppA Suppresses Seizures by Enhancing Adenosine Signaling in the Cortex

Abstract

Epilepsy is a multifactorial disorder associated with neuronal hyperexcitability that affects more than 1% of the human population. It has long been known that adenosine can reduce seizure generation in animal models of epilepsies. However, in addition to various side effects, the instability of adenosine has precluded its use as an anticonvulsant treatment. Here we report that a stable analogue of diadenosine-tetraphosphate: AppCH₂ppA effectively suppresses spontaneous epileptiform activity in vitro and in vivo in a Tuberous Sclerosis Complex (TSC) mouse model (Tsc1^+/−), and in postsurgery cortical samples from TSC human patients. These effects are mediated by enhanced adenosine signaling in the cortex post local neuronal adenosine release. The released adenosine induces A1 receptor-dependent activation of potassium channels thereby reducing neuronal excitability, temporal summation, and hypersynchronicity. AppCH₂ppA does not cause any disturbances of the main vital autonomous functions of Tsc1^+/− mice in vivo. Therefore, we propose this compound to be a potent new candidate for adenosine-related treatment strategies to suppress intractable epilepsies.

https://ift.tt/2OAK6h1

Saccadic Adaptation Boosts Ongoing Gamma Activity in a Subsequent Visuoattentional Task

Abstract

Attention and saccadic adaptation (SA) are critical components of visual perception, the former enhancing sensory processing of selected objects, the latter maintaining the eye movements accuracy toward them. Recent studies propelled the hypothesis of a tight functional coupling between these mechanisms, possibly due to shared neural substrates. Here, we used magnetoencephalography to investigate for the first time the neurophysiological bases of this coupling and of SA per se. We compared visual discrimination performance of 12 healthy subjects before and after SA. Eye movements and magnetic signals were recorded continuously. Analyses focused on gamma band activity (GBA) during the pretarget period of the discrimination and the saccadic tasks. We found that GBA increases after SA. This increase was found in the right hemisphere for both postadaptation saccadic and discrimination tasks. For the latter, GBA also increased in the left hemisphere. We conclude that oculomotor plasticity involves GBA modulation within an extended neural network which persists after SA, suggesting a possible role of gamma oscillations in the coupling between SA and attention.

https://ift.tt/2QwUsLY

Representing Multiple Observed Actions in the Motor System

Abstract

There is now converging evidence that others' actions are represented in the motor system. However, social cognition requires us to represent not only the actions but also the interactions of others. To do so, it is imperative that the motor system can represent multiple observed actions. The current fMRI study investigated whether this is possible by measuring brain activity from 29 participants while they observed 2 right hands performing sign language gestures. Three key results were obtained. First, brain activity in the premotor and parietal motor cortex was stronger when 2 hands performed 2 different gestures than when 1 hand performed a single gesture. Second, both individual observed gestures could be decoded from brain activity in the same 2 regions. Third, observing 2 different gestures compared with 2 identical gestures activated brain areas related to motor conflict, and this activity was correlated with parietal motor activity. Together, these results show that the motor system is able to represent multiple observed actions, and as such reveal a potential mechanism by which third-party social encounters could be processed in the brain.

https://ift.tt/2OIeFkK

High Sensitivity Mapping of Cortical Dopamine D2 Receptor Expressing Neurons

Abstract

Cortical D2 dopamine receptor (Drd2) have mostly been examined in the context of cognitive function regulation and neurotransmission modulation of medial prefrontal cortex by principal neurons and parvalbumin positive, fast-spiking, interneurons in schizophrenia. Early studies suggested the presence of D2 receptors in several cortical areas, albeit with major technical limitations. We used combinations of transgenic reporter systems, recombinase activated viral vectors, quantitative translatome analysis, and high sensitivity in situ hybridization to identify D2 receptor expressing cells and establish a map of their respective projections. Our results identified previously uncharacterized clusters of D2 expressing neurons in limbic and sensory regions of the adult mouse brain cortex. Characterization of these clusters by translatome analysis and cell type specific labeling revealed highly heterogeneous expression of D2 receptors in principal neurons and various populations of interneurons across cortical areas. Transcript enrichment analysis also demonstrated variable levels of D2 receptor expression and several orphan G-protein-coupled receptors coexpression in different neuronal clusters, thus suggesting strategies for genetic and therapeutic targeting of D2 expressing neurons in specific cortical areas. These results pave the way for a thorough re-examination of cortical D2 receptor functions, which could provide information about neuronal circuits involved in psychotic and mood disorders.

https://ift.tt/2Qw6h5e

Early Adolescence is a Critical Period for the Maturation of Inhibitory Behavior

Abstract

Psychiatric conditions marked by impairments in cognitive control often emerge during adolescence, when the prefrontal cortex (PFC) and its inputs undergo structural and functional maturation and are vulnerable to disruption by external events. It is not known, however, whether there exists a specific temporal window within the broad range of adolescence when the development of PFC circuitry and its related behaviors are sensitive to disruption. Here we show, in male mice, that repeated exposure to amphetamine during early adolescence leads to impaired behavioral inhibition, aberrant PFC dopamine connectivity, and reduced PFC dopamine function in adulthood. Remarkably, these deficits are not observed following exposure to the exact same amphetamine regimen at later times. These findings demonstrate that there is a critical period for the disruption of the adolescent maturation of cognitive control and PFC dopamine function and suggest that early adolescence is particularly relevant to the emergence of psychopathology in humans.

https://ift.tt/2OE8QFa

Clinical inertia, reverse clinical inertia, and medication non-adherence in type 2 diabetes

Abstract

Purpose

Clinical inertia and medication non-adherence are thought to contribute largely to the suboptimal glycemic control in many patients with type 2 diabetes. The present review explores the relations between A1C targets, clinical inertia and medication non-adherence in type 2 diabetes.

Methods

We searched PubMed for English-language studies published from 2001 through June 1, 2018. We also manually searched the references of selected articles, reviews, meta-analyses, and practice guidelines. Selected articles were mutually agreed upon by the authors.

Results

Clinical inertia is the failure of clinicians to initiate or intensify therapy when indicated, while medication non-adherence is the failure of patients to start or continue therapy that a clinician has recommended. Although clinical inertia may occur at all stages of diabetes treatment, the longest delays were reported for initiation or intensification of insulin. Medication non-adherence to antidiabetic drugs may range from 53 to 65% at 1 year and may be responsible for uncontrolled A1C in about 23% of cases. Reverse clinical inertia can be acknowledged as the failure to reduce or change therapy when no longer needed or indicated. Clinical inertia and medication non-adherence are difficult to address: clinician-and patient-targeted educational programs, more connected communications between clinicians and patients, the help of other health professional figures (nurse, pharmacist) have been explored with mixed results.

Conclusions

Both clinical inertia and medication non-adherence remain significant barriers to optimal glycemic targets in type 2 diabetes. Moreover, part of clinical inertia may be a way through which clinicians face current uncertainty in medicine, including some dissonance among therapeutic guidelines. Scientific associations should find an agreement about how to measure and report clinical inertia in clinical practice and should exhort clinicians to consider reverse clinical inertia as a cause of persisting inappropriate therapy in vulnerable patients.

https://ift.tt/2Rubj3x

Prevention of oral carcinogenesis in rats by Dracaena cinnabari resin extracts

Abstract

Objectives

In vivo study was performed to determine the chemopreventive efficacy of the DC resin methanol extract on a 4-nitroquinoline-1-oxide (4NQO) oral cancer animal model.

Materials and methods

This study involves administration of 4NQO solution for 8 weeks alone (cancer induction) or with Dracaena cinnabari (DC) extract at 100, 500, and 1000 mg/kg. DC extract administration started 1 week before exposure until 1 week after the carcinogen exposure was stopped. All rats were sacrificed after 22 weeks, and histological analysis was performed to assess any incidence of pathological changes. Immunohistochemical expressions of selected tumor marker antibodies were analyzed using an image analyzer computer system, and the expression of selected genes involved in apoptosis and proliferative mechanism related to oral cancer were evaluated using RT²-PCR.

Results

The incidence of OSCC decreased with the administration of DC extract at 100, 500, and 1000 mg/kg compared to the induced cancer group. The developed tumor was also observed to be smaller when compared to the induced cancer group. The DC 1000 mg/kg group inhibits the expression of Cyclin D1, Ki-67, Bcl-2, and p53 proteins. It was observed that DC 1000 mg/kg induced apoptosis by upregulation of Bax and Casp3 genes and downregulation of Tp53, Bcl-2, Cox-2, Cyclin D1, and EGFR genes when compared to the induced cancer group.

Conclusions

The data indicated that systemic administration of the DC resin methanol extract has anticarcinogenic potency on oral carcinogenesis.

Clinical relevance

Chemoprevention with DC resin methanol extract may significantly reduce morbidity and possibly mortality from OSCC.

https://ift.tt/2E3bBeT

Transcriptome analysis reveals the molecular response to cadmium toxicity in P. pseudoannulata

Abstract

Cadmium (Cd) can be transferred and accumulated in spiders, posing a survival risk to them. To analyze potential biological damage caused by Cd accumulation and relevant detoxification strategies employed by spiders in response to Cd exposure, we conducted transcriptome analysis of the 5th instar spider P. pseudoannulata, a common spider species playing a vital role in natural pest control in agricultural fields of southern China. We obtained 92,778 unigenes with an average length of 1104 bp and identified 302, 655, and 424 differentially expressed genes (DEGs) in the spiders fed with Cd-containing fruit flies for 2, 5, and 8 days, respectively. Results showed that the body mass of Cd-containing P. pseudoannulata were reduced when compared with controls, presumably due to delayed maturation of tissues and organs. Meanwhile, functional analysis of DEGs indicated that Cd may have a negative effect on neural signal transduction and molt cycle of the spider. For defense strategies, detoxification enzymes like glutathione S-transferase (GST), catalase (CAT), superoxide dismutase (SOD), and P450, and typical proteins like heat shock protein and metallothionein were all differentially expressed in response to Cd stress. Besides, innate immune responses like toll-like receptor signaling pathways were also upregulated. Multiple critical Cd-responsive genes involved in biological damage, detoxification, and immune response were identified, providing referable foundation for further research on Cd toxicity to P. pseudoannulata.

https://ift.tt/2QxkYov

Synthesis of coal fly ash zeolite for the catalytic wet peroxide oxidation of Orange II

Abstract

Fly ash, a coal combustion residue produced by Termotasajero in Colombia, has been hydrothermally treated after an alkaline fusion to produce zeolite without addition of silicon or aluminum. The starting material was thoroughly mixed with NaOH, in a 1:1.2 mass ratio, to obtain a homogeneous mixture that was heated to 100 °C during different times (6, 8, and 10 h) and three zeolite samples were produced. The samples were characterized by XRD, SEM, XRF, Mössbauer spectroscopy, and N₂ physisorption. According to characterization results (high surface area and appropriate morphological properties including crystallinity) and synthesis time, zeolitic catalyst synthesized with 8 h of hydrothermal treatment was selected to perform further analysis. This sample consisted of a mixture of zeolite X and zeolite A of high surface area (301 m² g⁻¹) and a Fe content of 6% wt/wt. The zeolite was used as a catalyst for the Fenton oxidation of Orange II. Experiments were performed in a laboratory batch reactor at 70 °C and constant pH = 3, using different concentrations of H₂O₂. When the stoichiometric amount of H₂O₂ was used, good mineralization (X_TOC = 45%), complete discoloration, and oxidant consumption were obtained after 240 min of reaction. The sample retained activity after 16 h of usage. The presence of Fe in the reaction media was always detected and a homogeneous Fenton mechanism induced by surface-leached iron is suggested.

https://ift.tt/2OEA2n6

Effectiveness of photopolymerization in composite resins using a novel 445-nm diode laser in comparison to LED and halogen bulb technology

Abstract

Challenges especially in the minimal invasive restorative treatment of teeth require further developments of composite polymerization techniques. These include, among others, the securing of a complete polymerization with moderate thermal stress for the pulp. The aim of this study is to compare current light curing sources with a blue diode laser regarding curing depth and heat generation during the polymerization process. A diode laser (445 nm), a LED, and a halogen lamp were used for polymerizing composite resins. The curing depth was determined according to the norm ISO 4049. Laser output powers of 0.1, 0.5, 1, and 2 W were chosen. The laser beam diameter was adapted to the glass rod of the LED and the halogen lamp (8 mm). The irradiation time was fixed at 40 s. To ascertain ΔT values, the surface and ground area temperatures of the cavities were simultaneously determined during the curing via a thermography camera and a thermocouple. The curing depths for the LED (3.3 mm), halogen lamp (3.1 mm) and laser_{(0.5/1 W)} (3/3.3 mm) showed no significant differences (p < 0.05). The values of ΔT_surface as well as ΔT_ground also showed no significant differences among LED, halogen lamp, and laser_{(1 W)}. The ΔT_surface values were 4.1_LED, 4.3_{halogen lamp}, and 4.5 °C for the laser while the ΔT_ground values were 2.7_LED, 2.6_{halogen lamp}, and 2.9 °C for the laser. The results indicate that the blue diode laser (445 nm) is a feasible alternative for photopolymerization of complex composite resin restorations in dentistry by the use of selected laser parameters.

https://ift.tt/2IEFEIs

Phytochemical screening and antityrosinase activity of carvacrol, thymoquinone, and four essential oils of Lebanese plants

Journal of Cosmetic Dermatology, EarlyView.


https://ift.tt/2yetzoG

Effect of intermittent teriparatide (PTH 1-34) on the alveolar healing process in orchiectomized rats

Abstract

Objective

To evaluate intermittent teriparatide therapy's influence on the alveolar healing process in rats with induced osteoporosis.

Materials and methods

Fifty-four male rats were divided into three groups: fictitious surgery (SHAM), bilateral orchiectomy (ORQ NT), and bilateral orchiectomy treated with teriparatide (ORQ TERI). Right upper incisor extraction was performed. After 14 and 42 days, the rats were euthanized. Immunolabeling analysis was performed in order to characterize bone turnover through Wnt, alcaline phosphatase, osteocalcin, and TRAP presence in tissue; micro-CT analysis was performed in order to determine the bone volume fraction (BV/TV), trabecular thickness, separation, and number (Tb.Th, Tb.Sp, Tb.N). For the micro-CT data, statistical analysis was performed through one-way ANOVA and Tukey post-test, for parametrical data, with significance level adopted in p < 0.05. Days, Wnt, alkaline phosphatase, and osteocalcin revealed more labeling for ORQ TERI and less for TRAP. For the Tb.N in the ORQ NT group was 0.496 mm, a significant statistical difference was observed between the groups of ORQ NT and ORQ TERI (p < 0.05). For the BV/TV, Tb.Sp, and Tb.Th parameters, no significant statistical difference was observed among the three experimental groups (p > 0.05).

Conclusions

Treatment with intermittent teriparatide reverted impairment in the metabolism of repairing bone tissue in orchiectomized animals.

Clinical relevance

Cases of decreased bone density such as osteoporosis can lead to delayed alveolar repair process. PTH 1-34 has been shown to be a medication that improves this repair, making bone of low quality into one with normal features.

https://ift.tt/2Nr7PeM

Removal of vanadium and palladium ions by adsorption onto magnetic chitosan nanoparticles

Abstract

Chitosan (CS), synthesized from chitin chemically extracted from shrimp shells, was used for the synthesis of magnetic chitosan nanoparticles (Fe₃O₄-CSN), which makes the adsorbent easier to separate. Fe₃O₄-CSN was used for the removal of toxic metals such as vanadium (V(V)) and palladium (Pd(II)) ions from aqueous solutions. Influencing factors on the adsorption process such as pH, contact time, adsorbent dosage, and agitation speed were investigated. A competitive adsorption of V(V) and Pd(II) ions for the active sites was also studied. The monolayer maximum adsorption capacities (Q_m) of 186.6 and 192.3 mg/g were obtained for V(V) and Pd(II) ions, respectively. The pseudo-second-order equation gave the best fit for the kinetic data, implying that chemisorption was the determining step. Freundlich model yielded a much better fit than the other adsorption models assessed (Langmuir, Temkin and Dubinin-Radushkevich). Thus, the adsorption of V(V) and Pd(II) ions onto Fe₃O₄-CSN is a combination of physical and chemical adsorption, as based on the kinetics and equilibrium study. Generally, physical adsorption is the mechanism that governs the system, while chemical adsorption is the slowest adsorption step that takes place. Thermodynamic studies displayed that the adsorption process was exothermic and spontaneous. Removal efficiencies of 99.9% for V(V) and 92.3% for Pd(II) ions were achieved, implying that Fe₃O₄-CSN adsorbent had an excellent ability for the removal of the metal ions from real industrial wastewaters without remarkable matrix effect.

Graphical abstract

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https://ift.tt/2IHnmGI

Letter to the editor re: Cheng, YH., Chou, WC., Yang, YF. et al. Environ Sci Pollut Res (2017). https://ift.tt/2zUNieZ

https://ift.tt/2Cvo8Xd

Silver and gold nanoparticles biosynthesized by aqueous extract of burdock root, Arctium lappa as antimicrobial agent and catalyst for degradation of pollutants

Abstract

This study presents an efficient and facile method for biosynthesis of silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs) using aqueous extract of burdock root (BR), A. lappa, and their applications. The nanoparticles were characterized by ultraviolet-visible spectrophotometry, X-ray diffraction, transmission electron microscopy, energy dispersive X-ray, thermogravimetry, and differential thermal analysis. AgNPs capped the BR extract (BR-AgNPs) possessed roughly spherical geometry with an average diameter of 21.3 nm while uneven geometry of AuNPs capped the BR extract (BR-AuNPs) showed multi shapes in average size of 24.7 nm. The BR-AgNPs strongly inhibited five tested microorganism strains. In particular, the nanoparticles showed excellent catalytic activity for the conversion of pollutants within wastewater. Pseudo-first-order rate constants for the degradation of 4-nitrophenol, methyl orange, and rhodamine B were respectively found 6.77 × 10⁻³, 3.70 × 10⁻³, and 6.07 × 10⁻³ s⁻¹ for BR-AgNPs and 6.87 × 10⁻³, 6.07 × 10⁻³, and 7.07 × 10⁻³ s⁻¹ for BR-AuNPs.

Graphical abstract

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https://ift.tt/2IE6kJr

A response surface methodology for optimization of 2,4-dichlorophenoxyacetic acid removal from synthetic and drainage water: a comparative study

Abstract

The potential of a granular activated carbon (GAC), a rice husk biochar (BRH), and multi-walled carbon nanotubes (MWCNTs) for removing 2,4-dichlorophenoxyacetic acid (2,4-D) from simulated wastewater and drainage water has been evaluated. In this regard, a response surface methodology (RSM) with a central composite design (CCD) (CCD-RSM design) was used to optimize the removal of 2,4-D from simulated wastewater under different operational parameters. The maximum adsorption capacities followed the order GAC > BRH > MWCNTs, whereas the equilibrium time increased in the order MWCNTs < GAC < BRH. In the case of GAC and BRH, the 2,4-D removal percentage increased significantly upon increasing the adsorbent dosage and temperature and decreased upon increasing the initial 2,4-D concentration and pH. The results showed that the contact time and temperature were not important as regards the adsorption efficiency of 2,4-D by MWCNTs, whereas rapid removal of 2,4-D from simulated wastewater was achieved within the first 5 min of contact with the MWCNTs. The results confirmed that the Freundlich isotherm model with the highest coefficient of determination (R²) and the lowest standard error of the estimate (SEE) satisfactorily fitted the 2,4-D experimental data. In addition, successful usage of the three adsorbents investigated was observed for removal of 2,4-D from drainage water from an agricultural drainage system. An economic analysis with a rate of return (ROR) method indicated that BRH could be used as an eco-friendly, low-cost, versatile, and high adsorption capacity alternative to GAC and MWCNTs for the removal of 2,4-D.

https://ift.tt/2Ctmt4d

Coffee waste, vector control, and dengue

https://ift.tt/2IE6h0d

Photobiomodulation on critical bone defects of rat calvaria: a systematic review

Abstract

Bone defects following trauma represent a high impact on the quality of life of millions of people around the world. The aim of this study was to review photobiomodulation (PBM) action in the treatment of bone critical defects in rat calvaria, related to evaluation of the current protocols applied. One hundred and forty-seven articles related to the subject were found by searching the main databases (Pubmed, Lilacs, Web of Science, and Scopus) considering the period of publication until the year 2017, and only 14 corresponded the inclusion criteria established for this systematic review. The main parameters of the PBM were expressed in Table 1. In addition, it was possible to observe the use of two different wavelengths (red and infrared), which are considered therapeutic. Most of the evaluated articles presented positive results that describe a greater amount of neoformed bone, an increase in collagen synthesis, and a contribution to microvascular reestablishment. However, two studies report no effect on the repair process when the PBM was used. In addition, we observed considerable variations between the values of power, fluence, and total energy, which make it difficult to compare the results presented between the selected studies. It was possible to conclude that the infrared laser was more effective in positively stimulating the bone repair process of critical defects. Furthermore, a discrepancy was found in the parameter values used, which made it difficult to choose the best protocol for the treatment of this type of lesion.

https://ift.tt/2E13mAc

Genotoxicity of water samples from an area of the Pampean region (Argentina) impacted by agricultural and livestock activities

Abstract

The aim of this study was to assess the genotoxic potential of surface waters located in a rural area in the north east of Buenos Aires province (Argentina) using the Allium cepa test. Water samples were collected at four sites located in a drainage channel and two sites on the Burgos stream that receives water from the channel, taking into account the sowing and harvesting months and rainfall periods. Analytical determinations revealed high total concentrations of Cd, Cu, Pb, and Zn (maximum values: 0.030, 0.252, 0.176, and 0.960 mg L⁻¹, respectively), and concentrations of glyphosate and its metabolite aminomethylphosphonic acid (AMPA), with maximum values of 13.6 and 9.75 μg L⁻¹, respectively. Statistically positive correlations were observed between the total metal concentrations and precipitation. No cytotoxicity (mitotic index MI) was observed in A. cepa. However, several water samples showed significant increases in micronucleus (MN) frequencies with respect to the controls. No correlations were observed between MN and the abiotic variables or precipitation. These results showed a state of deterioration in the water quality at the rural area studied in Buenos Aires province, and heavy metal contamination may contribute to the genotoxic activity. A. cepa was shown to be a useful tool for the detection of genotoxicity in water samples from areas with agricultural and livestock activities.

https://ift.tt/2IHlcH6

Study on dynamic adsorption of p-nitrophenol by multi-walled carbon nanotubes dispersed cyclodextrin

Abstract

In this paper, the modified multi-walled carbon nanotubes were prepared by β-cyclodextrin denoted as β-CD-MWNTs. The structure and morphology of β-CD-MWNTs was characterized by TEM and the dynamic adsorption of p-nitrophenol on β-CD-MWNTs was studied by the Thomas model. Some affecting factors of dynamic adsorption and the adsorbent regeneration process such as the sewage concentration, the amount of absorbent in column, including the type of reagent, solid-liquid ratio, regeneration time, and regeneration times were investigated and optimized. The results indicated that the p-nitrophenol removal rate could reach 84% under stuffing 2 g β-CD-MWNTs. The curves of p-nitrophenol's dynamic adsorption conformed to the Thomas model. Moreover, the adsorption capacity of regenerated β-CD-MWNTs was similar to the fresh β-CD-MWNT column. The optimal conditions of regenerations of β-CD-MWNTs were shown as follows: the type of reagent is anhydrous ethanol, the solid-liquid ratio is 200:40 (mg/mL) and the regeneration time is 120 min.

https://ift.tt/2Cumnt5

Metabotropic glutamate receptor subtype 5 is altered in LPS-induced murine neuroinflammation model and in the brains of AD and ALS patients

Abstract

Purpose

The aim of the present study was to determine the expression levels of mGluR5 in different mouse strains after induction of neuroinflammation by lipopolysaccharide (LPS) challenge and in the brains of patients with Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS) post mortem to investigate mGluR5 expression in human neurodegenerative diseases.

Methods

C57BL/6 and CD1 mice were injected intraperitoneally with either 10 mg/kg LPS or saline. mGluR5 and TSPO mRNA levels were measured after 1 and 5 days by qPCR, and mGluR5 protein levels were determined by PET imaging with the mGluR5-specific radiotracer [¹⁸F]PSS232. mGluR5 expression was evaluated in the post-mortem brain slices from AD and ALS patients using in vitro autoradiography.

Results

mGluR5 and TSPO mRNA levels were increased in brains of C57BL/6 and CD1 mice 1 day after LPS treatment and remained significantly increased after 5 days in C57BL/6 mice but not in CD1 mice. Brain PET imaging with [¹⁸F]PSS232 confirmed increased mGluR5 levels in the brains of both mouse strains 1 day after LPS treatment. After 5 days, mGluR5 levels in CD1 mice declined to the levels in vehicle-treated mice but remained high in C57BL/6 mice. Autoradiograms revealed a severalfold higher binding of [¹⁸F]PSS232 in post-mortem brain slices from AD and ALS patients compared with the binding in control brains.

Conclusion

LPS-induced neuroinflammation increased mGluR5 levels in mouse brain and is dependent on the mouse strain and time after LPS treatment. mGluR5 levels were also increased in human AD and ALS brains in vitro. PET imaging of mGluR5 levels could potentially be used to diagnose and monitor therapy outcomes in patients with AD and ALS.

https://ift.tt/2pFbso4

Characteristics, treatment and outcome of bleeding after tooth extraction in patients on DOAC and phenprocoumon compared to non-anticoagulated patients—a retrospective study of emergency department consultations

Abstract

Objectives

Bleeding after tooth extraction range from minor bleeding to life-threating haemorrhagic shock and are among the leading complications in patients under oral anticoagulation with direct oral anticoagulants (DOACs) or phenprocoumon. Little is known about how anticoagulation in patients under DOAC or phenprocoumon alters the characteristics, treatment or outcome of bleeding events, in comparison to non-anticoagulated patients.

Methods

Patients admitted to a tertiary ED in Bern, Switzerland, from June 1st 2012 to 31st May 2016 with bleeding related to tooth extraction under DOAC, phenprocoumon or without anticoagulation, were compared.

Results

Out of 161,458 emergency consultations, 64 patients with bleeding from tooth extraction were included in our study. In anticoagulation groups, we found significantly more delayed bleeding events than in patients without anticoagulation (9 (81.3%) DOAC, 19 (86.4%) phenprocoumon, 8 (30.8%) no anticoagulation, p < 0.001). Anticoagulated patients had to stay longer in the ED than non-anticoagulated patients, with no significant difference between DOAC or phenprocoumon (hours: 4.8 (3.2–7.6 IQR) DOAC, 3.0 (2.0–5.5 IQR) phenprocoumon, p = 0.133; 2.7 (1.6–4.6) no anticoagulation; p = 0.039). More patients with anticoagulation therapy needed surgery than patients without anticoagulant therapy (11 (68.8%) DOAC, 12 (54.6%) VKA, p = 0.506; 7(26.9%) no anticoagulation; p = 0.020).

Conclusions

Delayed bleeding occur more often in anticoagulated patients with both DOAC and phenprocoumon compared to patients without anticoagulation. Bleeding events in anticoagulated patients with DOAC and phenprocoumon equally need longer ED treatment and more frequent surgical intervention.

Clinical relevance

Caution with delayed bleeding in anticoagulated patients with DOACs and phenprocoumon is necessary and treatment of bleeding is resource-demanding.

https://ift.tt/2E2uNJP

FDG PET/CT for assessing tumour response to immunotherapy

Abstract

This paper follows the immunotherapy symposium held during the European Association of Nuclear Medicine (EANM) 2017 Annual Congress. The biological basis of the immune checkpoint inhibitors and the drugs most frequently used for the treatment of solid tumours are reviewed. The issues of pseudoprogression (frequency, timeline), hyperprogression and immune-related side effects are discussed, as well as their implications for patient management. A review of the recent literature on the use of FDG PET for assessment of immunotherapy is presented, and recommendations are provided for assessing tumour response and reporting immune-related side effects with FDG PET based on published data and experts' experience. Representative clinical cases are also discussed.

https://ift.tt/2OaHvuw

Magnesium depletion suppresses the anti-grazer colony formation in Scenedesmus obliquus

Abstract

In aquatic ecosystems, many phytoplankton species have evolved various inducible defense mechanisms against the predation. The expression of these defenses is affected by environmental conditions such as nutrient availability. Here, we investigated the anti-grazer colony formation in Scenedesmus obliquus at different magnesium concentrations (0–7.3 mg L⁻¹ Mg²⁺) in the presence of zooplankton (Daphnia)-derived infochemicals. Results showed that at adequate Mg²⁺, S. obliquus formed high proportions of multi-celled (e.g., four- and eight-celled) colonies, resulting in significantly increased number of cells per colony in response to Daphnia filtrate. On the other hand, in Mg²⁺-deficient treatment, the proportion of multi-celled colonies decreased, together with reduced algal growth rate and photosynthetic efficiency. Finally, the treatment without Mg²⁺ strongly suppressed the formation of large colony (mainly eight-celled colonies), whereas the algal growth rate was comparable to that in Mg²⁺ sufficient treatment. Despite the inhibition of colony formation, the time reaching the maximum number of cells per colony was not affected by the Mg²⁺ concentration, which generally took three days in all groups. Our results indicate that Mg²⁺ deficient/absent environments significantly reduced anti-grazing colony formation but not the algal growth, suggesting strong dependability of this morphological defensive trait to magnesium fluctuation in S. obliquus.

https://ift.tt/2BZgO4T

An event study analysis of price adjustment of refined oil and air quality in China

Abstract

Since marketization of the refined oil price, the Chinese government has used refined oil price adjustments to control air pollution. Using an event study analysis, we examine whether these price adjustments have impacted air quality. We test the abnormal returns of 12 price adjustments between 2014 and 2015 in 51 major cities of China. The results show that the impact on air quality of refined oil price decreases is larger than the impact of oil price increases. Although results indicate air quality has deteriorated, the impact is insignificant for most of the cities. Consequently, we conclude that price suspension of refined oil has had a negligible impact on air quality. This policy is not a viable method to improve the air quality in the short run.

https://ift.tt/2Cxr718

Chitosan oligosaccharides alleviate PM 2.5 -induced lung inflammation in rats

Abstract

Air pollution of particulate matter (PM), especially PM_2.5, has become a major public health problem in China. Exploration of therapeutic and preventive measures against PM_2.5 toxicity is of practical significance. The aim of this study was to examine the inhibitory effects of chitosan oligosaccharides (COS) on PM_2.5-induced lung inflammation in rats. Forty SPF (specific pathogen-free) male Wistar rats weighing 200–220 g were randomly divided into four groups: control group, COS group, PM_2.5 group, and PM_2.5+COS group. COS was pre-administered to rats by gavage at a single dose of 500 mg/kg 2 h before intratracheal instillation of PM_2.5 at a single dose of 1.2 mg/kg daily for 3 consecutive days. Normal saline (NS) was used as negative control. Twenty-four hours after the last instillation of PM_2.5, rats were sacrificed and subjected to bronchoalveolar lavage (BAL). The BAL fluids (BALF) were collected for measurement of levels of total proteins, lactate dehydrogenase (LDH), interleukin-1 (IL-1β), IL-8, and tumor necrosis factor-ɑ (TNF-ɑ) using colorimetric or ELISA kits. Levels of total proteins, LDH activities, and pro-inflammatory mediators including IL-1β, IL-8, and TNF-ɑ in BALF of rats in PM_2.5 group significantly increased in comparison with those of the control group. Pre-treatment of rats with COS markedly blocked PM_2.5-induced increase in LDH, IL-8, and TNF-ɑ levels in BALF. In conclusion, PM_2.5 exposure induces rat lung inflammation, which could be ameliorated by the pre-treatment of COS.

https://ift.tt/2BYbCy9

Intact Automatic Motor Inhibition in Attention Deficit Hyperactivity Disorder

Publication date: Available online 5 October 2018

Source: Cortex

Author(s): Marius Keute, Kerstin Krauel, Hans-Jochen Heinze, Max-Philipp Stenner

Abstract

Hyperactivity and impulsivity are defining symptoms of attention-deficit hyperactivity disorder (ADHD), next to inattention. Hyperactive and impulsive behavior in ADHD is often thought to result from a deficit in inhibitory motor control. However, testing for such a deficit is complicated by coexisting deficits in ADHD, specifically an impairment in maintaining task set, e.g., due to inattention. Typical inhibition paradigms, such as Stop-signal, Go/NoGo or Flanker paradigms, are susceptible to a fundamental confound between inhibition and inattention because inhibition is an explicit goal in these tasks. We eliminate this confound by studying the negative compatibility effect (NCE), reflecting a core inhibitory function in the human motor system which, in healthy individuals, inhibits movements automatically, i.e., without deliberation or even conscious awareness. Our behavioral analysis, including Bayesian model comparison, as well as the time-course of the lateralized readiness potential (LRP), consistently show that this function is intact in children with ADHD compared to healthy controls, independent of the presence or absence of prominent hyperactive-impulsive symptoms. We conclude that hyperactivity and impulsivity in ADHD do not result from a low-level deficit in motor inhibition.

https://ift.tt/2IF4h81

Evolutionary divergence of neuroanatomical organization and related genes in chimpanzees and bonobos

Publication date: Available online 5 October 2018

Source: Cortex

Author(s): Nicky Staes, Jeroen B. Smaers, Amanda E. Kunkle, William D. Hopkins, Brenda J. Bradley, Chet C. Sherwood

Abstract

Given their close genetic relatedness to humans, bonobos (Pan paniscus) and chimpanzees (Pan troglodytes) offer an essential comparative framework for studying the evolution of uniquely human traits. These two species differ markedly in their socio-behavioral repertoires, which is reflected in neuroanatomical differences that have been reported in the literature. However, phylogenetic comparative methods have not yet been used to map the evolution of neuroanatomical traits in bonobos and chimpanzees, limiting our ability to understand which neural systems are derived in each species in relation to the last common ancestor of Pan (Pan-LCA). Here, we examine evolutionary changes in neuroanatomical traits of bonobos and chimpanzees relative to ancestral character reconstructions of the Pan-LCA using comparative datasets from hominoids. We found that bonobo brains are derived in showing reduction of whole brain and white matter volumes, with particularly striking reduction of male brain size compared to the inferred Pan-LCA value. Brain structures related to social cognition and emotional regulation, like the insular cortex and amygdala, display a mosaic pattern of evolution with certain traits changing to a greater extent in each species. Examination of potential genetic mechanisms underlying divergence of neural and social traits did not reveal clear differences in protein evolution patterns between the two species. These findings suggest that the brain anatomy of extant bonobos and chimpanzees show lineage-specific specializations and neither can be considered to more closely retain the ancestral state of Pan. Consequently, this raises questions about the extent that modern chimpanzees or bonobos may serve as referential models for the neuroanatomy of the LCA of humans and apes.

https://ift.tt/2OL4kot

The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial

Publication date: Available online 4 October 2018

Source: Cortex

Author(s): Miranka Wirth, Gloria Benson, Claudia Schwarz, Theresa Köbe, Ulrike Grittner, Dietmar Schmitz, Stephan J. Sigrist, Jens Bohlken, Slaven Stekovic, Frank Madeo, Agnes Flöel

Abstract

Introduction

Nutritional intervention with the natural polyamine spermidine, an autophagy-enhancing agent, can prevent memory loss in aging model organisms. This is the first human study to evaluate the impact of spermidine supplementation on memory performance in older adults at risk for the development of Alzheimer's disease.

Methods

Participants with subjective cognitive decline (n = 30) were included in this three-months, randomized, placebo-controlled, double-blind Phase IIa pilot trial with a spermidine-rich plant extract supplement. Effects of intervention were assessed using the behavioral mnemonic similarity task at baseline and post-intervention visits. Data analysis was focused on reporting and interpreting effectiveness based on effect sizes.

Results

Memory performance was moderately enhanced in the spermidine group compared with placebo at the end of intervention (contrast mean = 0.17, 95% confidence interval [CI]: -0.01, 0.35, Cohen's d = 0.77, 95% CI: 0, 1.53). Mnemonic discrimination ability improved in the spermidine-treated group with a medium effect size (mean difference = -0.11, 95% CI: -0.19, -0.03, Cohen's d = 0.79, 95% CI: 0.01, 1.55). A similar effect was not found in the placebo-treated group (mean difference = 0.07, 95% CI: -0.13, 0.27, Cohen's d = -0.20, 95% CI: -0.94, 0.54).

Discussion

Nutritional spermidine was associated with a positive impact on memory performance in older adults with subject cognitive decline. This beneficial effect might be mediated by stimulation of neuromodulatory actions in the memory system. A follow-up Phase IIb randomized controlled trial will help validate the therapeutic potential of spermidine supplementation and delineate possible neurophysiological mechanisms of action in the target population.

Trial registration

Registered in ClinicalTrials.gov with the Identifier NCT02755246.

https://ift.tt/2BYmFY3

Oculomotor capture reveals trial-by-trial neural correlates of attentional guidance by contents of visual working memory

Publication date: Available online 4 October 2018

Source: Cortex

Author(s): Valerie M. Beck, Timothy J. Vickery

Abstract

Evidence from attentional and oculomotor capture, contingent capture, and other paradigms suggests that mechanisms supporting human visual working memory (VWM) and visual attention are intertwined. Features held in VWM bias guidance toward matching items even when those features are task irrelevant. However, the neural basis of this interaction is underspecified. Prior examinations using fMRI have primarily relied on coarse comparisons across experimental conditions that produce varying amounts of capture. To examine the neural dynamics of attentional capture on a trial-by-trial basis, we applied an oculomotor paradigm that produced discrete measures of capture. On each trial, subjects were shown a memory item, followed by a blank retention interval, then a saccade target that appeared to the left or right. On some trials, an irrelevant distractor appeared above or below fixation. Once the saccade target was fixated, subjects completed a forced-choice memory test. Critically, either the target or distractor could match the feature held in VWM. Although task irrelevant, this manipulation produced differences in behavior: participants were more likely to saccade first to an irrelevant VWM-matching distractor compared with a non-matching distractor – providing a discrete measure of capture. We replicated this finding while recording eye movements and scanning participants' brains using fMRI. To examine the neural basis of oculomotor capture, we separately modeled the retention interval for capture and non-capture trials within the distractor-match condition. We found that frontal activity, including anterior cingulate cortex and superior frontal gyrus regions, differentially predicted subsequent oculomotor capture by a memory-matching distractor. Other regions previously implicated as involved in attentional capture by VWM-matching items showed no differential activity across capture and non-capture trials, even at a liberal threshold. Our findings demonstrate the power of trial-by-trial analyses of oculomotor capture as a means to examine the underlying relationship between VWM and attentional guidance systems.

https://ift.tt/2OBJVly

The epigenetic landscape in the cardiovascular complications of diabetes

Abstract

A growing body of evidence suggests that epigenetic modifications—changes to the genome that do not involve changes in DNA sequence—may significantly derail transcriptional programs implicated in angiogenesis, oxidative stress and inflammation, thus fostering cardiovascular damage in patients with diabetes. Notably, adverse epigenetic signals acquired over the life course can be transmitted to the offspring, and may contribute to early cardiovascular phenotypes in the young generations. Hyperglycaemia and insulin resistance—key hallmarks of diabetes—induce an array of epigenetic modifications (i.e., DNA methylation, histone marks, and non-coding RNAs) which are responsible for a long-lasting impairment of vascular and cardiac function, even after intensive glycemic control. Hence, unveiling the "epigenetic landscape" in patients with diabetes may provide a post-genomic snapshot of global cardiovascular risk, and may furnish the tools to design personalized, epigenetic-based therapies to alleviate the burden of cardiovascular disease in diabetic patients. The present review aims to acquaint the scientific community with the rapidly advancing field of epigenetics and its implications in the cardiovascular complications of diabetes.

https://ift.tt/2OyVeuP

Late growth of infantile hemangiomas in children >3 years of age: A retrospective study

Publication date: Available online 5 October 2018

Source: Journal of the American Academy of Dermatology

Author(s): Kathleen F. O'Brien, Sonal D. Shah, Elena Pope, Roderic J. Phillips, Francine Blei, Eulalia Baselga, Maria C. Garzon, Catherine McCuaig, Anita N. Haggstrom, Peter H. Hoeger, James R. Treat, Marissa J. Perman, Jane S. Bellet, Xavier Cubiró, Jeffrey Poole, Ilona J. Frieden

Background

The proliferative phase of infantile hemangiomas (IHs) is usually complete by 9 months of life. Late growth beyond age 3 years is rarely reported.

Objective

To describe the demographic and clinic characteristics of a cohort of patients with late growth of IH, defined as growth in a patient >3 years of age.

Methods

A multicenter, retrospective cohort study.

Results

In total, 59 patients, 85% of which were female, met the inclusion criteria. The mean first episode of late growth was 4.3 (range 3-8.5) years. Head and neck location (55/59; 93%) and presence of deep hemangioma (52/59; 88%) were common characteristics. Posterior fossa malformations, hemangiomas, arterial anomalies, cardiac defects, eye abnormalities (PHACE) syndrome was noted in 20 of 38 (53%) children with segmental facial IH. Systemic therapy (corticosteroid or β-blocker) was given during infancy in 58 of 59 (98%) and 24 of 59 (41%) received systemic therapy (β-blockers) for late IH growth.

Limitations

The retrospective nature and ascertainment by investigator recall are limitations of the study.

Conclusion

Late IH growth can occur in children after 3 years of age. Risk factors include head and neck location, segmental morphology, and involvement of deep dermal/subcutaneous tissues.

https://ift.tt/2pBp0AT

Use of disposable blade for harvesting epidermal skin graft

Publication date: Available online 4 October 2018

Source: Journal of the American Academy of Dermatology

Author(s): Rajsmita Bhattacharjee, Keshavamurthy Vinay, Davinder Parsad

https://ift.tt/2IFMP39

Scholar : Pediatric Hematology and Oncology, Volume 35, Issue 2, March 2018 is now available online on Taylor & Francis Online

The online platform for Taylor & Francis Online content Pediatric Hematology and Oncology, Volume 35, Issue 2, March 2018 is now available online on Taylor & Francis Online. This new issue contains the following articles: Epidemiology An overview of disparities in childhood cancer: Report on the Inaugural Symposium on Childhood Cancer Health Disparities, Houston, Texas, 2016 Michael E. Scheurer, Philip J. Lupo, Joachim Schüz, Logan G. Spector, Joseph L. Wiemels, Richard Aplenc, M. Monica Gramatges, Joshua D. Schiffman, Maria S. Pombo-de-Oliveira, Jun J. Yang, Julia E. Heck, Catherine Metayer, Manuela A. Orjuela-Grimm, Kira Bona, Paula Aristizabal, Mary T. Austin, Karen R. Rabin, Heidi V. Russell & David G. Poplack Pages: 95-110 | DOI: 10.1080/08880018.2018.1464088 Global Hematology/Oncology and Clinical Practice Cardiotoxicity of anthracycline (ANT) treatment in children with malignant tumors Huimin Hu, Weiling Zhang, Dongsheng Huang, Qingmiao Yang, Jing Li & Yanan Gao Pages: 111-120 | DOI: 10.1080/08880018.2018.1459983 Leukemia, Lymphoma and Histiocytoses Successful treatment of systemic EBV positive T-cell lymphoma of childhood using the SMILE regimen Masanori Yoshida, Tomoo Osumi, Ken-Ichi Imadome, Daisuke Tomizawa, Motohiro Kato, Noritaka Miyazawa, Reiko Ito, Atsuko Nakazawa & Kimikazu Matsumoto Pages: 121-124 | DOI: 10.1080/08880018.2018.1459982 Usefulness of positron emission tomography-CT for diagnosis of primary bone marrow lymphoma in children Kyoko Moritani, Naoko Nakano, Sachiko Yonezawa, Fumihiro Ochi, Hisamichi Tauchi, Minenori Eguchi-Ishimae, Mariko Eguchi, Eiichi Ishii & Kozo Nagai Pages: 125-130 | DOI: 10.1080/08880018.2018.1459984 Epigenetic silencing of the tumor suppressor genes SPI1, PRDX2, KLF4, DLEC1, and DAPK1 in childhood and adolescent lymphomas İhsan Özdemir, Faruk Güçlü Pınarlı, Ferda Alpaslan Pınarlı, F. Nur Baran Aksakal, Arzu Okur, Pınar Uyar Göçün & Ceyda Karadeniz Pages: 131-144 | DOI: 10.1080/08880018.2018.1467986 Non-Malignant Hematology Impact of zinc on sexual maturation of female sickle cell anemia (SCA) children in Enugu, Southeast Nigeria Vivian Ozoemena Onukwuli, Josephat Chinawa, Christopher Bismarck Eke, Ada Rosemary Nwokocha, Ifeoma Josephine Emodi & Anthony Nnaemeka Ikefuna Pages: 145-155 | DOI: 10.1080/08880018.2018.1469706 Solid Tumors and Neurooncology Chromogranin A and neuron-specific enolase in neuroblastoma: Correlation to stage and prognostic factors | Kleopatra Georgantzi M.D., Erik G. Sköldenberg M.D., Ph.D., Mats Stridsberg M.D., Ph.D., Per Kogner M.D., Ph.D., Åke Jakobson M.D., PhD, Eva Tiensuu Janson M.D., Ph.D. & Rolf H. B. Christofferson M.D., Ph.D. Pages: 156-165 | DOI: 10.1080/08880018.2018.1464087 To update which email alerts you receive, manage your alerts within the My Account area. Unsubscribe from new content alerts for this journal (both new issue and latest article notifications) with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : Africa Review, Volume 10, Issue 2, July - December 2018 is now available online on Taylor & Francis Online

The online platform for Taylor & Francis Online content Africa Review, Volume 10, Issue 2, July - December 2018 is now available online on Taylor & Francis Online. This new issue contains the following articles: Articles Official development assistance and the factors impeding its effectiveness in Africa Ifeoma Ifeyinwa Momah Pages: 129-139 | DOI: 10.1080/09744053.2018.1485252 Narratives, climate change and agricultural policy processes in Malawi Blessings Chinsinga & Michael Chasukwa Pages: 140-156 | DOI: 10.1080/09744053.2018.1485253 Gender difference in higher education in Ethiopia: a case of Addis Ababa University (AAU) Kitaw Kassie Pages: 157-172 | DOI: 10.1080/09744053.2018.1485254 Concentric circles of South Africa's climate diplomacy Oluwole Olutola & Chris Landsberg Pages: 173-187 | DOI: 10.1080/09744053.2018.1485255 The study of political science in South Africa and beyond: the search for relevance Clive J. Napier & Pieter Labuschagne Pages: 188-205 | DOI: 10.1080/09744053.2018.1485256 The underlying reasons for the emerging dynamic of regional security cooperation against Boko Haram Elysée Martin Atangana Pages: 206-215 | DOI: 10.1080/09744053.2018.1485257 Book Review Kenya: The struggle for a new constitutional order Bijay Ketan Pratihari Pages: 216-218 | DOI: 10.1080/09744053.2018.1485258 Do you have original research that relates to present-day Japan and its recent historical development? Contemporary Japan welcomes your submissions. To update which email alerts you receive, manage your alerts within the My Account area. Unsubscribe from new content alerts for this journal (both new issue and latest article notifications) with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : Arts & Health, Volume 10, Issue 3, October 2018 is now available online on Taylor & Francis Online

The online platform for Taylor & Francis Online content Arts & Health, Volume 10, Issue 3, October 2018 is now available online on Taylor & Francis Online. This new issue contains the following articles: Reviews The personal benefits of musicking for people living with dementia: a thematic synthesis of the qualitative literature Robyn Dowlen, John Keady, Christine Milligan, Caroline Swarbrick, Nick Ponsillo, Lucy Geddes & Bob Riley Pages: 197-212 | DOI: 10.1080/17533015.2017.1370718 Articles Art museums as a source of well-being for people with dementia: an experience in the Prado Museum Manuel H. Belver, Ana M. Ullán, Noemi Avila, Carmen Moreno & Clara Hernández Pages: 213-226 | DOI: 10.1080/17533015.2017.1381131 Using participatory and creative research methods to develop and pilot an informative game for preparing children for blood tests Kate Oulton, Naomi Oldrieve, Julie Bayliss, Victoria Jones, Isobel Manning, Lisa Shipway & Faith Gibson Pages: 227-240 | DOI: 10.1080/17533015.2017.1392329 Impact of creative workshops for people with severe mental health problems: art as a means of recovery Javier Saavedra, Samuel Arias, Paul Crawford & Elvira Pérez Pages: 241-256 | DOI: 10.1080/17533015.2017.1381130 Reports Painting in situ: the benefits of live mural painting for residents on two secure long-term care dementia units Megan E. Graham & Andréa Fabricius Pages: 257-273 | DOI: 10.1080/17533015.2017.1370717 To update which email alerts you receive, manage your alerts within the My Account area. Unsubscribe from new content alerts for this journal (both new issue and latest article notifications) with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : New articles have been published for Journal of Natural History, Volume 52, Issue 33-34

The online platform for Taylor & Francis Online content The following articles have been newly published in the issue Journal of Natural History, Volume 52, Issue 33-34 on Taylor & Francis Online: Articles A new species of Friesea (Collembola: Neanuridae) from the Antarctic Continent Penelope Greenslade Pages: 2197-2207 | DOI: 10.1080/00222933.2018.1523483 The issue is in progress. To view all articles already published in this issue, please visit: https://www.tandfonline.com/toc/tnah20/52/33-34 Hoping to have your article read by anyone, anywhere and at any time? Find out more about publishing open access with Ecosystem Health and Sustainability. To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Radiosurgery as primary management for Acromegaly

Clinical Endocrinology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2OIz2i0

Estimated Cost Efficacy of US Food and Drug Administration Approved Treatments for Acne

Dermatologic Therapy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2zSY6dV

A “Seasonal Bromoderma” in a Farmer

Dermatologic Therapy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2Qwzb5f

Rituximab therapy in pemphigus: a long‐term follow‐up

Dermatologic Therapy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2zTTF2w

New alcohol flushing in a patient with atopic dermatitis under therapy with dupilumab

Dermatologic Therapy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2QumhEM

Intralesional 2% zinc sulfate solution for plane warts: A case report

Dermatologic Therapy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2zTx4D7

A case report demonstrating potential utility of topical imiquimod for cutaneous Rosai–Dorfman disease

Dermatologic Therapy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2QuYsfY

Secondary failure of TNF‐α inhibitors in clinical practice

Dermatologic Therapy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2zSxObr

Polymethylmethacrylate‐induced nodules of the lips – clinical presentation and management by intralesional neodymium:YAG laser therapy

Dermatologic Therapy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2QtE2UE

Efficacy and safety of cyclosporine in Stevens‐Johnson syndrome and toxic epidermal necrolysis

Dermatologic Therapy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2zSY4Tl

Imiquimod 5% cream in occlusion, for the treatment of lentigo maligna: a new scheme of short cycles and the need for clinical trials

Dermatologic Therapy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2QsI5AH

First case of trastuzumab emtansine‐associated hemorrhagic telangiectasias treated with propranolol

Dermatologic Therapy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2zTxoBP

Non‐Specific labelling of macrophages with Anti‐Cytokeratin 20 (SP33) in the evaluation of nodal micrometastasis from merkel cell carcinoma: A Pitfall for metastasis

Journal of Cutaneous Pathology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2OaS29r

Novel and recurrent mutations in keratin 1 cause epidermolytic ichthyosis and palmoplantar keratoderma

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2DYVCi8

Juvenile pemphigus vulgaris manifesting as vegetating skin lesions

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2Oa3Sk3

Dystrophic epidermolysis bullosa pruriginosa presenting with flagellate scarring lesions

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2E0KIbL