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Τρίτη 12 Απριλίου 2022

Retreatment of Recurrent or Second Primary Head and Neck Cancer After Prior Radiation: Executive Summary of the American Radium Society® (ARS) Appropriate Use Criteria (AUC): Expert Panel on Radiation Oncology - Head and Neck Cancer:

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Publication date: Available online 8 April 2022

Source: International Journal of Radiation Oncology*Biology*Physics

Author(s): Matthew C. Ward, Shlomo A. Koyfman, Richard L. Bakst, Danielle N. Margalit, Beth M. Beadle, Jonathan J. Beitler, Steven Shih-Wei Chang, Jay S. Cooper, Thomas J. Galloway, John A. Ridge, Jared R. Robbins, Assuntina G. Sacco, C. Jillian Tsai, Sue S. Yom, Farzan Siddiqui

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TCTAP C-175 Valve-In-Valve Transcatheter Aortic Valve Replacement in a Patient With Severe Left Ventricular Systolic Dysfunction in Previous Bentall Procedure

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Publication date: 19 April 2022

Source: Journal of the American College of Cardiology, Volume 79, Issue 15, Supplement

Author(s): Satej Janorkar, Sachin Shirke, Prashant Mishra, Nilesh Juvekar

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Poor Treatment Outcomes with Second-Line Chemotherapy in Advanced Synovial Sarcoma

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Via Oncology
Conclusion: Our exploratory study revealed that the response rate of second-line chemotherapy regimens for patients with synovial sarcoma was 9.4%. Therefore, there is an urgent need to develop more active therapeutic regimens for synovial sarcomas. (Source: Oncology)
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NeuroEMCrit – Time is Brain – Acute Ischemic Stroke Part 2: Mechanical Thrombectomy

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part II of the stroke update...

EMCrit Project by NeuroEMCrit Team (Casey & Neha).

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Retrospective analysis of adjuvant radiotherapy in oral cavity or oropharyngeal cancer: Feasibility of omitting lower-neck irradiation

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by Sheng-Yow Ho, Wan-Chen Kao, Sheng-Yen Hsiao, Sheng-Fu Chiu, Sung-Wei Lee, Jia-Chun Chen, Li-Tsun Shieh

Objectives

Adjuvant radiotherapy is the standard of care in locally advanced head and neck cancers. The radiation field is correlated with the surgical field in the adjuvant radiotherapy setting; therefore, tailoring the irradiation field is reasonable.

Materials and methods

We retrospectively analyzed patients with oral cavity and oropharyngeal cancers included in the cancer registry between 2015 and 2019 in the study hospital. Patients who underwent whole-neck irradiation (WNI) were compared with those who underwent lower-neck–sparing (LNS) irradiation.

Results

A total of 167 patients with oral cavity and oropharyngeal cancers were included in the study. Cancer recurrence was recorded in 33% of the patients. The rate of recurrence of oral cavity and oropharyngeal cancer at neck level IV was 8%. The 2-year incidence of level IV recurrence was lower in the WNI group than in the LNS group (2% vs. 10%; p = 0.04). The 2-year disease-free survival rates were 75% and 63% in the WNI and LNS groups, respectively (p = 0.08).

Conclusion

The rate of level IV recurrence was higher in the LNS group than in the WNI group. Trends of improvement in disease-free survival with lower-neck irradiation suggested that it is premature to consider LNS irradiation as daily practice in patients with oral cavity and oropharyngeal cancer.

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