Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
Ετικέτες
Πέμπτη 30 Αυγούστου 2018
Oxidation of Ti-6Al-4V During Wire and Arc Additive Manufacture
3D Printing and Additive Manufacturing, Ahead of Print.
https://ift.tt/2wvam22
Dominant dystrophic epidermolysis bullosa pruriginosa with a COL7A1 exon 87 c.6898C>T mutation
Clinical and Experimental Dermatology, EarlyView.
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Beatboxers and Guitarists Engage Sensorimotor Regions Selectively When Listening to the Instruments They can Play
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Aldosterone to Renin Ratio as Screening Tool in Primary Aldosteronism
Exp Clin Endocrinol Diabetes
DOI: 10.1055/a-0672-0836
Primary aldosteronism (PA) is a severe and often underdiagnosed form of secondary hypertension. Determining the aldosterone to renin ratio (ARR) in hypertensive patients has been shown to be a valuable screening test for identification of patients suffering from PA. Since the introduction of a more widespread ARR screening the number of PA patients significantly increased worldwide. Interpretation of ARR might be challenging: Several factors from posture to interfering drugs affect the ARR and need to be taken into account when collecting samples. In addition, the wide variety of available assay methods and lack of well-established cut-offs present a challenge to the clinician. This review discusses the usefulness and possible difficulties of ARR screening.
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© Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Abstract | Full text
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Total and high affinity corticosteroid‐binding globulin depletion in septic shock is associated with mortality
Clinical Endocrinology, Volume 0, Issue ja, -Not available-.
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Nab-Paclitaxel and Gemcitabine as First-line Treatment of Advanced or Metastatic Cholangiocarcinoma
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Management of Liver Neuroendocrine Tumors in 2018
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Financial Conflicts of Interest Among Oncologist Authors of Reports of Clinical Drug Trials
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Downstaging and Survival Outcomes Associated With Neoadjuvant Chemotherapy Regimens Among Patients With Bladder Cancer
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Bevacizumab Plus Standard-of-Care Treatment After Progression in Advanced Non–Small Cell Lung Cancer
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Scholar : Chinese Law & Government, Volume 50, Issue 2, 2018 is now available online on Taylor & Francis Online
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Scholar : Dance Education in Practice, Volume 4, Issue 3, 2018 is now available online on Taylor & Francis Online
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Brain magnetic resonance imaging using a customized vacuum shape-keeping immobilizer without sedation in preterm infants
Publication date: Available online 30 August 2018
Source: Magnetic Resonance Imaging
Author(s): Yamamura Kenichiro, Takatsu Yasuo, Miyati Toshiaki, Inatomi Tadashi
Abstract
Objective
To validate that a customized vacuum shape-keeping immobilizer (VaSKI) can be used in preterm infants without sedation.
Methods
Preterm infants who underwent brain MRI from February 2008 to March 2017 at Osaka Medical College Hospital were retrospectively assigned to the sedation group (February 2008 to September 2013, n = 64) or VaSKI group (October 2013 to November 2016, n = 64). The examination success rates and diagnosable case classification were determined by pediatricians and radiologists. We compared the time from preparation to examination completion between the groups. Furthermore, we measured the time from immobilization to sleep in the preterm infants in the VaSKI group.
Results
The examination success rate was 90.6% in both of the groups. The median (interquartile range) times of preparation were 24.0 (15.3) and 18.0 (13.0) min in the sedation and VaSKI groups, respectively. In the VaSKI group, the time from immobilization to sleep was within 3 min in 87.1% of the preterm infants.
Conclusions
The brain MRI examination success rates and motion artifact suppression effects were equivalent between the groups, whereas the time from preparation to examination completion was much shorter in the VaSKI group. Therefore, the VaSKI was validated as an immobilizer for MRI in preterm infants without using sedation.
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Development of a robust diffusion-MR elastography (dMRE) technique to mitigate intravoxel phase dispersion
Publication date: Available online 30 August 2018
Source: Magnetic Resonance Imaging
Author(s): Daiki Ito, Tomokazu Numano, Kazuyuki Mizuhara, Toshikatsu Washio, Masaki Misawa, Naotaka Nitta
Abstract
Diffusion-magnetic resonance elastography (dMRE) is an emerging practical technique that can acquire diffusion magnetic resonance imaging and MRE simultaneously. However, a signal loss attributable to intravoxel phase dispersion (IVPD) interferes with the calculation of the apparent diffusion coefficient (ADC). This study presents an approach to dMRE that reduces the influence of IVPD by introducing a new pulse sequence. The existing and proposed techniques were performed using a phantom comprising five rods with different elasticities at 60 Hz vibration to investigate the accuracy of previous and proposed dMRE techniques. The measures of ADC and stiffness, obtained by using both dMRE techniques, were compared with conventional spin-echo (SE) diffusion and SE-MRE. Then, we evaluated those differences by using the mean of absolute differences (MAD) in each rod within the phantom. The results of the MAD of the stiffness from both dMRE techniques showed almost no difference. In contrast, the value of the ADC MAD (MAD ≒ 0.16 × 10−3 mm2/s), obtained in the soft region within the phantom with the previous dMRE technique, was large. This value was about 2.7 times that of the value produced by the proposed dMRE technique. This difference must reflect the degree of influence of IVPD in both techniques. These results demonstrate that our dMRE technique is a robust method for addressing the signal loss attributable to IVPD.
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Minimal number of gradient directions for robust measurement of spherical mean diffusion weighted signal
Publication date: Available online 30 August 2018
Source: Magnetic Resonance Imaging
Author(s): Hua Li, Ho Ming Chow, Diane C. Chugani, Harry T. Chugani
Abstract
Purpose
Determination of the minimum number of gradient directions (Nmin) for robust measurement of spherical mean diffusion weighted signal (S¯).
Methods
Computer simulations were employed to characterize the relative standard deviation (RSD) of the measured spherical mean signal as a function of the number of gradient directions (N). The effects of diffusion weighting b-value and signal-to-noise ratio (SNR) were investigated. Multi-shell high angular resolution Human Connectome Project diffusion data were analyzed to support the simulation results.
Results
RSD decreases with increasing N, and the minimum number of N needed for RSD ≤ 5% is referred to as Nmin. At high SNRs, Nmin increases with increasing b-value to achieve sufficient sampling. Simulations showed that Nmin is linearly dependent on the b-value. At low SNRs, Nmin increases with increasing b-value to reduce the noise. RSD can be estimated as σS¯N, where σ = 1/SNR is the noise level. The experimental results were in good agreement with the simulation results. The spherical mean signal can be measured accurately with a subset of gradient directions.
Conclusion
As Nmin is affected by b-value and SNR, we recommend using 10 × b / b1 (b1 = 1 ms/μm2) uniformly distributed gradient directions for typical human diffusion studies with SNR ~ 20 for robust spherical mean signal measurement.
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A feasible study on using multiplexed sensitivity-encoding to reduce geometric distortion in diffusion-weighted echo planar imaging
Publication date: Available online 29 August 2018
Source: Magnetic Resonance Imaging
Author(s): Xinyuan Chen, Ye Zhang, Ying Cao, Rui Sun, Peng Huang, Yingjie Xu, Wenqing Wang, Qinfu Feng, Jianping Xiao, Junlin Yi, Yexiong Li, Jianrong Dai
Abstract
Purpose
Single-shot (SS) echo planar imaging (EPI) is commonly used for diffusion-weighted imaging (DWI) in radiation treatment planning. The geometric distortion of single-shot diffusion-weighted EPI (SS-DWEPI) limits its utility in precision radiotherapy. We aimed to investigate the use of multiplexed sensitivity-encoding DWEPI (MUSE-DWEPI) to reduce the geometric distortions to allow its use in brain radiotherapy.
Methods
In a phantom study, phantom diameters measured using MUSE-DWEPI and SS-DWEPI were compared and the percentages of geometric distortion (%GD) were calculated. The shifting vectors of control points were also plotted and calculated. In a patient study, ten patients (six with post-surgery glioma, four with brain metastases) requiring MRI were enrolled, and the image distortion levels in SS-DWEPI and MUSE-DWEPI were compared using T2 Periodically Rotated Overlapping Parallel Lines with Enhanced Reconstruction (T2 PROPELLER) images as the reference. The tumor targets and four brain regions were delineated based on T2 PROPELLER, SS-DWEPI, and MUSE-DWEPI, using the Dice similarity coefficient (DSC) and the Hausdorff distance (HD) to quantify the level of geometric distortion.
Results
In the phantom study, the most prominent image distortion was along the phase encoding direction in terms of %GD fluctuated from 7%–8% for SS-DWEPI (b = 0 s/mm2 and 1000 s/mm2) and fluctuated from 2%–3% for MUSE-DWEPI (b = 0 s/mm2 and 1000 s/mm2) with different positions and b values. The mean relative displacement of all control points was 4.45 ± 3.44 mm for SS-DWEPI b0 and 2.17 ± 1.9 mm for MUSE-DWEPI b0 close to the isocenter. Increasing the distance away from the isocenter in the z direction, the distortion increased more in SS-DWEPI. For all brain regions and targets involved, higher DSC values and lower HDs were obtained using MUSE-DWEPI than with SS-DWEPI (p < .01). The mean improvement in HD when switching from SS-DWEPI to MUSE-DWEPI was 3.65 ± 1.31 mm.
Conclusions
MUSE-DWEPI is an improvement upon SS-DWEPI in geometric distortion reduction, which might be a promising application strategy for DWI in radiotherapy.
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Regular and Irregular Inflection in Down Syndrome – New Evidence from German
Publication date: Available online 29 August 2018
Source: Cortex
Author(s): Martina Penke
Abstract
The study aims to explore whether regular inflectional morphology is affected in children/adolescents with Down syndrome (DS). German past participle forms were elicited for ten regular and ten irregular inflected verbs as well as for five novel verbs. Data were collected from a group of 21 monolingual German children and adolescents with DS (chronological age M = 11;03 years) and a group of 21 typically developing monolingual German children (chronological age M = 4;03 years) matched in chronological age to the nonverbal mental age of the DS group (mental age DS group M = 4;05 years). Data analysis indicated that eight children/adolescents with DS displayed a deficit in acquiring the regular participle marker -t and in applying it as default inflection in German participle formation. In contrast, a group of 13 individuals with DS performed similar to the typically developing control children. They had successfully acquired the regular participle affix -t and readily applied it as default inflection to produce participles for irregular verbs and novel verbs. The data indicate that the acquisition of regular inflectional morphology is not outside the scope of individuals with DS and succeeded in many affected individuals. However, a substantial number of individuals with DS displayed a selective deficit with regular default inflection. The occurrence of a selective deficit with regular default inflection in individuals with DS supports dualistic views to inflection, according to which two different cognitive components are involved in regular and irregular inflection that can be selectively affected in language disorders.
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Feasibility of radiotherapy in nonagenarian patients: a retrospective study
Abstract
Purpose
Specific information about radiation therapy in nonagenarians is limited. In order to shed more light on the feasibility of radiotherapy in this challenging subgroup, a retrospective study was performed.
Methods
The data of 93 consecutive patients receiving irradiation treatment at the Department of Radiation Oncology, Ordensklinikum Linz Barmherzige Schwestern between June 2005 and December 2016 were analyzed. Patient- and treatment-related factors were extracted from the patient records. Overall survival (OS) was defined as time from irradiation to death or last follow-up. The survival rates were analyzed using the Kaplan-Meier method and log-rank test.
Results
The study population of 93 patients was between 90 and 99 years old (median 91 years). It included 59 women (63%) and 34 men (37%). Of these, 38 (41%) received definitive radiotherapy, 14 (15%) received neoadjuvant or adjuvant radiotherapy, whereas a palliative regimen was prescribed in 44% of the cases (n = 41). In all, 79 patients (85%) were able to complete their prescribed course of radiotherapy. While 16 (17%) patients reported grade 2 toxicities or higher, 4 had ≥grade 3 side effects (4%). The median survival was significantly higher in patients treated with adjuvant, neoadjuvant or definitive radiotherapy (13.8 months) compared to patients treated with palliative radiotherapy (3.6 months; p < 0.001).
Conclusion
Even in patients managed without preradiotherapy comprehensive geriatric assessment, carefully planned fractionated radiotherapy was feasible and resulted in acceptable rates of acute toxicities.
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Exposure to Environmental Tobacco Smoke and Prevalence of Atopic Dermatitis among Adolescents in Kuwait
Dermatology
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Scholar : ΣΤΟΜΑΤΙΤΙΣ - νέα αποτελέσματ
THE ROLE OF CANDIDA ALBICANS ON THE DEVELOPMENT OF STOMATITIS IN PATIENTS WEARING DENTURES
who wear dentures. It is believed that in 60-65% of cases the cause of this
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Role of Dentists in the Management of Behҫet's Disease: A Case Report
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IMPROVEMENTS IN OR RELATING TO DNA RECOMBINATION
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[HTML] Effects of Nd: YAG laser irradiation on the growth of Candida albicans and Streptococcus mutans: in vitro study
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[PDF] Clinico-Laboratory Assessment of Adherence to Gluten Free Diet among Children with Celiac disease
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[PDF] Management of oral cavity disorders during chemotherapy in oncologic patients
tears, photophobia, taste change, metal taste during infusion, it can cause increased
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[HTML] A Girl With Concentric, Target-Shaped Lesions on Her Hands, Arms, and Legs
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METHODS AND COMPOSITIONS FOR RNRA-GUIDED TREATMENT OF HIV INFECTION
viruses (AAV), and vesicular stomatitis virus (VSV) and retroviruses), liposomes and other
lipid-containing complexes, and other macromolecular complexes capable of mediating …
METHODS AND COMPOSITIONS FOR RNA-GUIDED TREATMENT OF HIV INFECTION
viruses (AAV), and vesicular stomatitis virus (VSV) and retroviruses), liposomes and other
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[PDF] Targeting IKKβ in Cancer: Challenges and Opportunities for the Therapeutic Utilisation of IKKβ Inhibitors
human inflammatory disorders and malignancies. Consequently, the NF-κB
pathway has attracted attention as an attractive therapeutic target for drug …
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Scholar : intitle:Bioprinting - νέα αποτελέσματα
[PDF] 3D-Bioprinting: A stepping stone towards enhanced medical approaches
escalation driving the field of artificial tissue and organ construct and brought
metamorphosis in regenerative medicine. Prime advancement has been attained …
[PDF] THE 3D BIOPRINTING AS NOVEL REALM IN IT MEDICINE
confined space using 3D printing technologies, where cell function and viability are
preserved within the printed construct. Three-dimensional (3D) printing includes pre …
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Scholar : Laryngomalacia - νέα αποτελέσματα
Hematemesis in an Infant
(A). His past medical history was significant for high-pitched inspiratory stridor in the first
weeks of life, which had been diagnosed as laryngomalacia via direct laryngoscopy …
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Scholar : ΜΕΝΙΕΡΕ - νέα αποτελέσματα
[HTML] Bilateral Vestibulopathy-Current Knowledge and Future Directions to Improve its Diagnosis and Treatment
interested in vestibular nerve section to treat Meniere's disease. He achieved early
success at controlling vertigo in patients with Meniere's disease …
AGENT EXHIBITING ANTI-STRESS, ANXIOLYTIC AND ANTI-DEPRESSION ACTIVITY, AND COMPOSITION BASED THEREON
affective disorders, schizoaffective disorders, manic conditions of various
genesis, affective disorders in chronic alcoholism, drug dependence, sexual …
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Summary Insulinomas are rare neuroendocrine tumours that classically present with fasting hypoglycaemia. This case report discusses an un...
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