Safety assessment of standardized aqueous Brucea javanica extract in rats

Publication date: 6 April 2018
Source:Journal of Ethnopharmacology, Volume 215
Author(s): Farahdina Man, Chee-Yan Choo
Ethnopharmacological relevanceThe seeds of Brucea javanica and its aqueous decoction is a traditional medicine consumed by diabetic patients in Malaysia. The daily consumption of B. javanica seeds and it's aqueous decoction causes much concern as the quassinoids and its glycosides from the seeds exhibited various pharmacological activity at low doses.Aims of studyThe aim of the present study is to evaluate the repeated dose toxicity of the standardized aqueous extract administered daily for 30 days through oral administration at its effective hypoglycemia doses.Materials and methodsThe seeds were dried, ground and extracted in deionized water. A HPLC-photodiode array method was developed and validated for the standardization of both the hypoglycemia agents, namely bruceine D and E in aqueous extract. Both normoglycemia and streptozotocin (STZ)-induced diabetic rats were fed orally with 15, 30 and 60mg/kg body weight of standardized aqueous extract. The blood glucose was measured at 0–8h. In repeated dose toxicity, similar doses were administered orally to rats for 30 days. At the end of 30 days, the blood was withdrawn and subjected to biochemical and haematology analysis while organs were harvested for histology analysis.ResultsOral administration of standardized aqueous extract exhibited a dose-response relationship in both the normoglycemia and STZ-induced diabetic rats. Daily oral administration of 15, 30 and 60mg/kg standardized aqueous extract for 30 days to rats did not show signs to toxicity in its biochemical, haematology and histology analysis.ConclusionIn conclusion, although the seeds were reported to contain compounds with various pharmacological activity, the daily oral administration to rats for 30 days do not showed signs of toxicity at its effective hypoglycemia doses.

Graphical abstract

http://ift.tt/2EyzO9a

Inhibitory effects of Aconiti Lateralis Radix Preparata on chronic intermittent cold-induced inflammation in the mouse hypothalamus

Publication date: 6 April 2018
Source:Journal of Ethnopharmacology, Volume 215
Author(s): Wonnam Kim, Wonil Lee, Jin Gyu Choi, In Gyoung Ju, Yun-Kyung Kim, Tae Hee Lee, Myung Sook Oh
Ethnopharmacological relevanceAconiti Lateralis Radix Preparata (AR) is the most frequently used herb to generate heat and treat symptoms associated with coldness in Asia.Aims of the studyThe hypothalamus is one of the master regulators to maintain constant core body temperature. Chronic exposure to cold stress disturbs homeostatic regulation, gradually resulting in hypothalamic inflammation. This study investigate the effects of AR, on the chronic intermittent cold (CIC)-induced release of pro-inflammatory signaling molecules in the mouse hypothalamus.Materials and methodsAconiti Lateralis Radix Preparata extract (ARE) were solubilized in distilled water and diluted with saline before administration. Male ICR mice (7 weeks old, 30–32g) were divided randomly into 6 groups: (1) control, (2) cold stress, (3) ARE 30, (4) ARE 100, (5) ARE 300, and (6) ARE 1000mg/kg groups. Groups (2)-(6) were exposed to CIC stress once a day for 14 days. CIC stress was achieved by exposing the mice to 4°C and 60 ± 10% humidity for 120min once a day. Rectal temperature was measured after terminating cold stress. Cortisol levels were measured from serum. Hypothalamus tissue was used for western blot analysis, and IL-9, IL-13, PGE1, and PGE2 levels were assessed.ResultsARE treatment prevented the CIC-induced decrease in rectal temperature and increase in serum cortisol level. ARE-treated CIC-exposed mice demonstrated decrease in nuclear c-Fos levels dose-dependently compared to CIC-exposed mice. Nuclear NF-kB expression showed significant increase in CIC-exposed mice. ARE treatment significantly blunted the increase in nuclear NF-kB expression. CIC-exposed mice had significantly increased levels of both IL-9 and IL-13. Treatment with ARE suppressed the elevated IL-9 and IL-13 levels. Between control and CIC-exposed mice PGE1 levels showed no difference. However ARE (1000mg/kg)-treated CIC-exposed mice had a significant increase in PGE1 level compared to CIC-exposed mice. PGE2 levels were significantly higher in CIC-exposed mice compared to control mice. ARE treatment significantly attenuated the increase in PGE2 levels.ConclusionsOur findings suggest CIC stress disturbs the anti-inflammatory effect of cortisol and maintenance of the body temperature. Thus AR contributes to suppress the activated proinflammatory factors, IL-9, IL-13, and PGE-2, and to increase the heat production.

Graphical abstract

http://ift.tt/2EvX5sl

Scholar : Obstructive sleep apnea - νέα αποτελέσματα

Down syndrome and pediatric obstructive sleep apnea surgery: A national cohort

AA Ong, CM Atwood, SA Nguyen, RJ Teufel, C Lal… - The Laryngoscope, 2017

Methods Analysis of the 1997 to 2012 editions of the Kid's Inpatient Database was
conducted. Using International Classification of Diseases, Ninth Revision codes, all patients
with OSA were identified, and subsequently, subgroups of NS children and children with DS

STOP-Bang questionnaire: the validation of a Portuguese version as a screening tool for obstructive sleep apnea (OSA) in primary care

A Rebelo-Marques, C Vicente, B Valentim… - Sleep and Breathing, 2017

Aim This work aimed to test the performance of the STOP-Bang questionnaire for the
suspicion/diagnosis of obstructive sleep apnea. Methods Eight-month prospective study; all
patients referred from PC to the respective sleep clinic accompanied by a completed and

Improved Boosting Algorithms by Pre-Pruning and Associative Rule Mining on Decision Trees for Predicting Obstructive Sleep Apnea

DYY Sim, CS Teh, AI Ismail - Advanced Science Letters, 2017

An improved Boosting algorithm, named as Boosted PARM-DT, was developed by pre-
pruning techniques and Associative Rule Mining (ARM) on decision trees built from the
clinical datasets a collected for Obstructive Sleep Apnea (OSA). The Pruned-Associative-

Sleep quality, obstructive sleep apnea, and psychological distress in truck drivers: a cross-sectional study

O Guglielmi, N Magnavita, S Garbarino - Social Psychiatry and Psychiatric …, 2017

Abstract Purpose Sleep disorders are highly prevalent in truck drivers. The aim of this study
is to evaluate the prevalence of self-reported obstructive sleep apnea (OSA) and poor sleep
quality in truck drivers, and to analyze the relationship between sleep problems and mental

Hypopharyngeal Evaluation in Obstructive Sleep Apnea with Awake Flexible Laryngoscopy: Validation and Updates to Cormack‐Lehane and Modified Cormack …

C Torre, S Zaghi, M Camacho, R Capasso, SYC Liu - Clinical Otolaryngology, 2017

This article has been accepted for publication and undergone full peer review but has not been
through the copyediting, typesetting, pagination and proofreading process, which may lead to
differences between this version and the Version of Record. Please cite this article as doi:

[HTML] Obstructive Sleep Apnea Presenting as Non-epileptic Spells: A Unique Combination

P Natteru, C Rupareliya, X Zhou, PC Bollu - Cureus, 2017

Abstract Obstructive sleep apnea (OSA), an increasingly prevalent sleep disorder, has been
extensively studied in both clinical and scientific settings. In most cases, the diagnosis of
sleep apnea is straightforward with patients having symptoms of snoring, choking or gasping

Effect of Positional therapy on Patients with Obstructive Sleep Apnea: Meta-Analysis

E Lee, JH Choi, B Lee, JH Jung, SW Seon, S Lee… - Journal of Rhinology, 2017

Results Finally, twenty two studies from 21 papers were included in the meta-analysis.
Positional therapy significantly decreased AHI by 54.1%[ROM, 0.459; 95% confidence
interval (CI), 0.394 to 0.534] and increased lowest oxygen saturation by 3.3%(ROM, 1.033;

Role of common hypnotics on the phenotypic causes of obstructive sleep apnoea: paradoxical effects of zolpidem

JC Carberry, LP Fisher, RR Grunstein, SC Gandevia… - European Respiratory …, 2017

[PDF] Nonlinear Diagnoses on Autonomic Imbalance on a Single Night Before Treatment for Sleep Apnea: A Proposed Scheme Based Upon Heartbeat Indices

YH Shiau, JH Sie - Neuropsychiatry (London), 2017

… References 1. Parish JM, Somers VK. Obstructive sleep apnea and cardiovascular disease.
Mayo. Clin. Proc 79(8), 1036-1046 (2004). 2. Gupta MA, Simpson FC. Obstructive sleep apnea
and psychiatric disorders: A systematic review. J. Clin. Sleep …

P-154 Depressive symptoms in patients with obstructive sleep apnea are related with daytime sleepiness and obesity

HH Kang, SB Kim, HS Moon, SH Lee - 대한결핵및호흡기학회 추계학술발표초록집, 2017

Introduction: Patients with OSA commonly complain of fatigue, daytime sleepiness, and poor
sleep quality. Depression and obstructive sleep apnea (OSA) are two common entities, with
common symptoms that make identification of either condition difficult. We evaluated factors

 

Ακύρωση ειδοποίησης

Δημιουργία λίστας των ειδοποιήσεών μου

Αυτή η ειδοποίηση αποστέλλεται από τον Μελετητή Google. Ο Μελετητής Google είναι μια υπηρεσία που παρέχεται από την Google.

Scholar : ΛΟΓΟΣ - νέα αποτελέσματα

[PDF] ОНТОЛОГИЯ ОДИНОЧЕСТВА ПОЖИЛЫХ ЛЮДЕЙ В СТРУКТУРЕ СУЩНОСТИ ЧЕЛОВЕЧЕСКОГО БЫТИЯ

СВ Козин, КК Лямцева - П 78 Проблемы социального и научно-технического …, 2017

… философского осмысления. Вышеупомянутые философы следовали гносеологии
(от др.-греч. γνῶσις– «познание»,«знание» и λόγος–«слово»,«речь»)–это теория
познания, раздел философии. Уже в XX в. феномен …

Logos and Dao Revisited: A Non-Metaphysical Interpretation

S Burik - Philosophy East and West, 2018

… In Vorträge und Aufsätze Heidegger reinterprets Λόγος (logos) from the Greek verb λέγειν (legein,
to gather, to say) as "the Laying that gathers" (die lesende Lege) (Heidegger 1994b, p. 208; 1975,
p. 66), thinking with this term that which consists of gathering together and letting …

[PDF] Рецензенты: доктор технических наук, профессор

ИА Кленова - 2017

… Экология – наука о доме, обители человека (от др.-греч. «οἶκος» – дом, жилище и «λόγος» –
учение). Термин «экология» возник сравнительно недавно, но свой вклад в эту науку внесли
еще ученые древности: Аристотель, Гиппократ, Эпикур и др …

[PDF] Nietzsche ve Aristoteles' te "Hakikat" Meselesi

ZE ÖZER - DTCF Dergisi, 2017

… hakkındaki bilgisi, tümevarım ile evrensel ya da genelin bilgisine (τέχνη) dönüşmüştür.
Λόγος ile ilişkisiyle şeylerin açıklayıcı bilgisine, ἐπιστήμη, ulaşılır. Birincil nedenlerin
ve ilkelerin bilgisi olan σοφία Aristoteles'e göre ilk ilkeler ve …

[PDF] Терминологическое поле экология/ecology в русском и английском языках (на материале текстов образовательного дискурса сферы природопользования)

ДТН Чинь - 2017

Page 1. Министерство образования и науки Российской Федерации федеральное
государственное автономное образовательное учреждение высшего образования
«НАЦИОНАЛЬНЫЙ ИССЛЕДОВАТЕЛЬСКИЙ ТОМСКИЙ ПОЛИТЕХНИЧЕСКИЙ …

[PDF] The Diodorean approach to time and modality from a historical and a philosophical perspective

F Corpina, P Øhrstrøm - Logic and

… 340–280 BC). 1 In particular, they have discussed his Master Argument or kyrieuon
logos (κυριεύων λόγος), which was de- signed to demonstrate that if something is
possible then either it is the case already or it will be the case later …

[HTML] Polemological paradigm of hybrid war research

D Roman, K Hryhorii, D Vera, K Maryna - Философия и космология, 2017

… Owing to the polemological (from πολέμιος war and λόγος study) approach the authors managed
to systematize and summarize the theories of war and peace, clarify contemporary western
concepts of warfare, outline the specifi cs of the Russian view on the hybrid war concept …

[PDF] Ραδιόφωνο και εκπαίδευση: απόψεις εκπαιδευτικών για τη συμβολή του European School Radio στην εκπαιδευτική διαδικασία

Α Γενιτζές - 2017

… Σημαντικός λόγος παράλληλα ήταν η ανάγκη της συστηματικής καταγραφής της λειτουργίας του,
της επιστημονικής τεκμηρίωσης της και της ανάλυσης των απόψεων των ίδιων των εκπαιδευτικών
που το χρησιμοποιούν στην εκπαιδευτική πράξη. Page 6. vi Ευχαριστίες …

[PDF] Squaring the Circle and Saving the Phenomena: Reading Science in the Greek Language Classroom

G Irby

Page 1. Teaching Classical Languages Volume 8, Issue 2 1 Irby Irby, Georgia. "Squaring
the Circle and Saving the Phenomena: Reading Science in the Greek Language Classroom."
Teaching Classical Languages 8.2: xx-xx. ISSN 2160-2220 …

Pitagorejska palingenesia

Ž Kaluđerović

… ἅπαντα ὅσα περὶ τοῦ πράττειν ἢ μὴ πράττειν διορίζουσιν, ἐστόχασται τῆς πρὸς τὸ θεῖον
ὁμιλίας, καὶ ἀρχὴ αὕτη ἐστὶ καὶ βίος ἅπας συντέτακται πρὸς τὸ ἀκολουθεῖν τῶι θεῶι
καὶ ὁ λόγος οὗτος ταύτης ἐστὶ τῆς φιλοσοφίας, ὅτι γελοῖον ποιοῦσιν ἄνθρωποι …

 

Ακύρωση ειδοποίησης

Δημιουργία λίστας των ειδοποιήσεών μου

Αυτή η ειδοποίηση αποστέλλεται από τον Μελετητή Google. Ο Μελετητής Google είναι μια υπηρεσία που παρέχεται από την Google.