miR-150-5p inhibits osteogenic differentiation of fibroblasts in ankylosing spondylitis by targeting VDR

xlomafota13 shared this article with you from Inoreader miR-150-5p inhibits osteogenic differentiation of fibroblasts in ankylosing spondylitis by targeting VDR Via Experimental and therapeutic medicine Exp Ther Med. 2022 Apr;23(4):283. doi: 10.3892/etm.2022.11213. Epub 2022 Feb 15. ABSTRACT Dysregulated microRNAs (miRNAs or miRs) serve potential roles in inflammatory systemic disease, including ankylosing spondylitis (AS). The aim of the present study was to investigate the potential function of miR-150-5p in osteogenic differentiation of AS fibroblasts and its underlying mechanism. The expression of miR-150-5p and vitamin D receptor (VDR) in AS joint capsules and fibroblasts was detected by reverse transcription-quantitative (RT-q)PCR and western blotting. Following overexpression of miR-150-5p, the alteration in osteogenic gene expression was detected by RT-qPCR, western blotting and alkaline phosphatase activity assay, as well as alizarin red staining. The association between miR-150-5p and VDR was confirmed by luciferase assay and rescue experiments were performed. Patients with AS exhibited decreased expression of miR-150-5p in joint capsules. Treatment with bone morphogenic protein 2 (BMP-2) and transforming growth factor-β1 (TGF-β1) led to downregulation of miR-150-5p in AS fibroblasts. Enforced expression of miR-150-5p attenuated osteogenic differentiation of AS fibroblasts. These results demonstrated that miR-150-5p inhibited osteogenic differentiation of AS fibroblasts by targeting VDR. miR-150-5p overexpression decreased osteogenic transformation of fibroblasts by decreasing VDR expression in AS. PMID:35317439 | PMC:PMC8908459 | DOI:10.3892/etm.2022.11213 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

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miR-150-5p inhibits osteogenic differentiation of fibroblasts in ankylosing spondylitis by targeting VDR
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Effectiveness of gabapentin in reducing opioid requirements after radiation in head and neck cancer in a single institution
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Radiologic–pathologic correlation of major versus minor extranodal extension in oral cavity cancer
Head & Neck

Effectiveness of gabapentin in reducing opioid requirements after radiation in head and neck cancer in a single institution
20h
by
David R. Gilley, Andrew D. Clark, Maggie E. Wieser, Craig A. Bollig, Laura M. Dooley, Gregory B. Biedermann
via
Head & Neck
Abstract
Background
Gabapentin has been shown to reduce opioid use in head and neck cancer patients. Here, we examine the efficacy of prophylactic gabapentin at reducing opioid use in these patients at our institution.

Methods
A retrospective study of patients receiving radiation was performed, using patients from our previous study as controls. Risk factors for opioid use at 3 and 6 months were determined using univariate and multivariate analyses.

Results
In total, 53/185 patients were treated with gabapentin, 39.6% of which took opioids at 3 months vs. 58.3% in the non-gabapentin cohort (p = 0.021). Gabapentin was independently associated with less opioid use on multivariate analysis at 3 months (OR 0.47, 95% CI 0.24–0.9). Gastrostomy tube dependence and pretreatment opioid use were associated with chronic opioid use despite gabapentin.

Conclusions
Gabapentin is effective at expediting opioid tapering in head and neck cancer patients who are not gastrostomy tube dependent or taking opioids pretreatment.

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Radiologic–pathologic correlation of major versus minor extranodal extension in oral cavity cancer
20h
by
Michael A. Blasco, Christopher W. Noel, Tra Truong, Shao Hui Huang, David P. Goldstein, Jonathan C. Irish, Ralph Gilbert, Ali Hosni, Andrew Hope, Brian O'Sullivan, John Waldron, Bayardo Perez‐Ordonez, Ilan Weinreb, Stephen M. Smith, Eric Bartlett, Eugene Yu, John R. Almeida
via
Head & Neck
Abstract
Background
To evaluate the diagnostic performance of radiologic extranodal extension (rENE) in predicting major (>2 mm) and minor (≤2 mm) pathologic ENE (pENE).

Methods
All oral cavity squamous cell carcinoma patients who underwent neck dissection with pathological nodal disease (pN+) between 2010 and 2015 were reviewed. Preoperative computed tomography and/or magnetic resonance imaging were reviewed by two head and neck neuroradiologists.

Results
Three hundred and thirty-four patients were included. The sensitivity and specificity of rENE were 37% [95% CI 29–44] and 98% [95% CI 96–100], respectively. Sensitivity for pENE improved in the subset of patients with major ENE (48% [95% CI 38–57]). The presence of rENE was associated with inferior 3-year overall survival: 26% [95% CI 17–41] versus 60% [95% CI 54–67].

Conclusions
This large cohort study demonstrates high specificity, but low sensitivity for preoperative imaging in the detection of pENE in OCSCC. Patients with rENE demonstrated poor OS. pENE in the absence of rENE is still an adverse risk factor.

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,

Telephone consultation 11855 int 1193,

Neue Therapieansätze für Speicheldrüsenmalignome

xlomafota13 shared this article with you from Inoreader Neue Therapieansätze für Speicheldrüsenmalignome Via Laryngo-Rhino-Otologie Laryngorhinootologie DOI: 10.1055/a-1792-2246 In den vergangenen Jahren haben sich durch die Verbesserung und Verbreitung molekularpathologischer Testverfahren und die Möglichkeit von zielgerichteten Therapien neue Optionen in der Behandlung von Speicheldrüsenmalignomen ergeben. Durch die neuen zielgerichteten Therapieoptionen werden Patienten deutlich weniger toxische Alternativen zur konventionellen zytostatischen Chemotherapie geboten. Zum einen gibt es neue entitätsspezifische Therapien, wie z.B. die Therapie mit NTRK-Inhibitoren bei sekretorischen Karzinomen und die Therapie mit Axitinib bei adenoidzystischen Karzinomen. Darüber hinaus rücken aber auch entitätsübergreifende Therapeutika, wie z.B. die antiandrogene The rapie, die HER2-Inhibition oder auch die PI3K-Inhibition, in den Vordergrund. Bei metastasierten/rezidivierten Speicheldrüsenkarzinomen, welche nicht mit einer zielgerichteten Therapie behandelt werden können, werden weiterhin hauptsächlich platinbasierte Chemotherapien eingesetzt. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Endoscopic dacryocystorhinostomy for refractory nasolacrimal duct obstruction with a small lacrimal sac (≤ 5 mm in diameter)

xlomafota13 shared this article with you from Inoreader Endoscopic dacryocystorhinostomy for refractory nasolacrimal duct obstruction with a small lacrimal sac (≤ 5 mm in diameter) Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2022 Mar 23. doi: 10.1007/s00405-022-07347-1. Online ahead of print. ABSTRACT BACKGROUND: Although endoscopic dacryocystorhinostomy (DCR) is a standard procedure for nasolacrimal duct obstruction (NLDO), the failure rate remains approximately 10%. A small lacrimal sac is considered the main reason for surgical failure. We explored the efficacy of endoscopic DCR for the treatment of NLDO with a small lacrimal sac. METHODS: The clinical data of 72 patients (88 eyes) diagnosed with NLDO and undergoing endoscopic DCR from 2012 to 2020, with at least 24 months of follow-up were retrospectively collected. Intraoperatively, the Rosenmüller valves were fully exposed, mucosal flaps were preserved to cover the naked bone, and a silicone tube was implanted if necessary. Postoperative intervention was performed if necessary. The main outcome measures were symptomatic improvement and objective ostium patency. RESULTS: Eighty-eight eyes of 72 patients were divided into two groups: the refractory group (34 patients, 47 eyes), with a small lacrimal sac (≤ 5 mm in diameter), and the simple group (38 patients, 41 eyes). Patients with small lacrimal sacs were more prone to bilateral eye disease than those in the simple group (P = 0.014) and required a longer postoperative follow-up (P < 0.001). Refractory NLDO and simple NLDO had a success rate of 91.5% and 95.1%, respectively, with no significant difference. CONCLUSION: Endoscopic DCR for refractory NLDO with a small lacrimal sac could achieve a beneficial result by exposing the Rosenmüller valves, preserving mucosal flaps, implanting necessary intubation, and intervening postoperatively. Thus, a small lacrimal sac should not be regarded as a contraindication to surgery. PMID:35320400 | DOI:10.1007/s00405-022-07347-1 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Pelvic Pain after italian coffee consumption : Ischemic colitis (IC) is an inflammatory condition of the large intestine, or colon. It develops when there isn't enough blood flow to the colon.

Pelvic pain occurs mostly in the lower abdomen area. The pain might be steady, or it might come and go. It can be a sharp and stabbing pain in a specific spot, or a dull pain that is spread out. If the pain is severe, it might get in the way of your daily activities.Pelvic pain can be steady, or it can come and go. It can be a sharp and stabbing pain felt in a specific spot, or a dull pain that is spread out.

Ischemic colitis occurs when blood flow to part of the large intestine (colon) is temporarily reduced, usually due to constriction of the blood vessels supplying the colon or lower flow of blood through the vessels due to low pressures.

For patients who present with symptoms of ischemia, a CT scan of the abdomen with oral and IV contrast and laboratory testing can be performed. Manifestations of ischemic colitis on CT include colonic wall thickening, edema, thumbprinting, bowel dilatation, and effusion of intestinal circumference.

  

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,

Telephone consultation 11855 int 1193,