Jellyfish‐like sonographic pattern can help recognition of dermatofibrosarcoma protuberans. Report of 3 new cases and review of the literature

Australasian Journal of Dermatology, EarlyView.


https://ift.tt/2yhGRlh

A non-interventional multicenter study to document the implants success and survival rates in daily dental practices of the CONELOG screw-line implant

Abstract

Objective

This multicenter prospective non-interventional study evaluated the success and survival of the CONELOG implants inserted according to the standard protocol with one- or two-step surgery in daily practice three years after loading. Changes of soft tissue and bone level over time, esthetical outcome, and patient satisfaction were assessed.

Materials and methods

The study included patients in six centers. The implants were used in accordance with standard practice of each particular center, and the use was documented systematically. Failure rate, implant success, bone level changes, different clinical parameters, and patients' satisfaction were assessed.

Results

In total, 130 dental implants were placed in 94 patients (64 female, 30 male). Mean age of patients was 50.4 ± 13.7. At 3-year post-loading, 108 implants in 78 patients were available for evaluation. Success and survival rate were 98.4% after placement and 100% 36 months post-loading. Bone loss from surgery to loading was 0.52 ± 0.55 mm. From loading to 36 months post-loading, the bone level change remained stable. Patient assessments were performed for function, ability to chew, speech, esthetics, and general satisfaction. Patients were very satisfied (82.3%) or satisfied (16.1%). None of the patients was dissatisfied.

Conclusion

The 3-year results of this non-interventional multicenter study indicate that the CONELOG implants are reliable and effective over the course of the observation while used in standard conditions of daily environment and confirm the results obtained in controlled clinical trials.

Clinical relevance

Performance of CONELOG implants under daily routine is similar to controlled clinical trials.

https://ift.tt/2J0j7q0

The case for a national survey of eating disorders in Australia

Abstract

In this Commentary we outline the case for a national survey of eating disorders in Australia. Given the recent focus of the federal government to provide further funding for mental health research, we call for a national survey to be made a key priority. Such high-quality, nationally representative data are critically important to informing all other domains of eating disorders research in the Australian context, and to informing the research agenda internationally.

https://ift.tt/2AaI9Qc

Editorial Board

Publication date: November 2018

Source: Journal of Autoimmunity, Volume 94

Author(s):

https://ift.tt/2AbhbIp

White blood cell mitochondrial DNA copy number is decreased in rheumatoid arthritis and linked with risk factors. A twin study

Publication date: Available online 14 October 2018

Source: Journal of Autoimmunity

Author(s): Anders J. Svendsen, Qihua Tan, Marianne A. Jakobsen, Bharat Thyagarajan, Marianne Nygaard, Lene Christiansen, Jonas Mengel-From

Abstract

Low mitochondrial DNA copy number (mtDNA CN) has been associated with e.g. cancer, cardiovascular and autoimmune diseases. We aimed to study a potential association between mtDNA CN and rheumatoid arthritis (RA).

The relative quantity of mitochondrial DNA compared to nuclear DNA was measured in peripheral white blood cells from 149 RA affected twin pairs and 1321 non-affected twin pairs. Multiple regression analysis including RA discordant twin pairs was performed in order to separate specific effects of RA and familial RA predisposition using non-RA affected twin pairs as reference group. In addition, we performed a twin pair level analysis including only RA discordant twin pairs evaluating the effect of cell type, auto antibodies and RA genetic risk factors.

Both the RA twins and their non-affected co-twins had significantly lower mtDNA CN than non-affected twins (−28.7 and −23.1 mtDNA CN, respectively). Adjusting for cell count attenuated these differences (−23.1 mtDNA CN and −20.1 mtDNA CN respectively). Within RA discordant twin pairs PTPN22(T) positive RA twins had a significantly lower amount than their co-twins (−16.3 mtDNA CN). PTPN22(T) had no effect among twins from non-affected twin pairs.

MtDNA CN is significantly lower in persons with established RA and in predisposed non-affected RA co-twins suggesting that mitochondrial variation may be involved in the RA disease pathways. Our results also suggest that the RA associated genetic risk factor, PTPN22(T), further decreases the mtDNA CN, but only in carriers with established RA.

https://ift.tt/2QQ8msS

Cognitive Symptoms in US Government Personnel in Cuba: The mending is worse than the hole

Publication date: Available online 13 October 2018

Source: Cortex

Author(s): Sergio Della Sala, Robert D. McIntosh, Roberto Cubelli, Jason A. Kacmarski, Holly M. Miskey, Robert D. Shura

https://ift.tt/2QNJulG

Firing Up Glycolysis: BCG Vaccination Effects on Type 1 Diabetes Mellitus

Publication date: Available online 13 October 2018

Source: Trends in Endocrinology & Metabolism

Author(s): Rinke Stienstra, Mihai G. Netea

In addition to the impact of Bacillus Calmette–Guerin (BCG) vaccination on antimicrobial host defence, a novel study reveals beneficial effects on glycaemic control in patients with long-standing type 1 diabetes mellitus (T1DM). These effects are ascribed to an accelerated glucose consumption in immune cells due to increased glycolysis and reduced oxidative phosphorylation.

https://ift.tt/2Pzu2t2

Normal human skin is superior to monkey esophagus substrate for detection of circulating BP180‐NC16A‐specific immunoglobulin G antibodies in bullous pemphigoid

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2QSpdeL

Prediction of Disease Relapse in a Cohort of Juvenile Localized Scleroderma Patients

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2CJR6Cz