The safe use of Doliocarpus dentatus in the gestational period: Absence of changes in maternal reproductive performance, embryo-fetal development and DNA integrity

Publication date: 10 May 2018
Source:Journal of Ethnopharmacology, Volume 217
Author(s): Raissa Borges Ishikawa, Juliana Miron Vani, Silvia Cordeiro das Neves, Ana Paula Maluf Rabacow, Cândida Aparecida Leite Kassuya, Júlio Croda, Claudia Andrea Lima Cardoso, Antônio Carlos Duenhas Ferreira Monreal, Andreia Conceição Milan Brochado Antoniolli, Andréa Luiza Cunha – Laura, Rodrigo Juliano Oliveira
Ethnopharmacological relevanceDoliocarpus dentatus (Dilleniaceae) is commonly used in Brazil for the treatment of inflammatory process pain and urinary retention. Previous studies of our group have demonstrated the anti-inflammatory and antimycobacterial action of the ethanolic extract of Doliocarpus dentatus (EEDd) as well as the safety of its use.Aim of the studywe investigated the effects of EEDd on reproductive performance, fetal development and DNA integrity in pregnant female Swiss mice.Material and methodsthirty female Swiss mice were divided into three experimental groups (n = 10): control group treated with 1% tween-80 and EEDd1 and EEDd2 groups treated with EEDd at doses of 100 and 1000 mg/kg, respectively. The treatment occurred by oral gavage throughout the gestational period. At the end of pregnancy, parameters related to reproductive performance, embryofoetal development and DNA integrity was evaluated.Resultsboth doses of the extract tested did not alter the reproductive parameters, did not present significant differences in the embryofetal development when compared to the control group and also did not induce the formation of micronuclei.Conclusionthe EEDd do not alter the reproductive parameters, embryofetal development and DNA integrity, ensuring its safe use during pregnancy.

Graphical abstract

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Editorial Board

Publication date: 6 April 2018
Source:Journal of Ethnopharmacology, Volume 215





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Time-resolved fluorescence spectroscopy for the diagnosis of oral lichen planus

Summary

Background

Lichen planus (LP) is a T-cell mediated autoimmune disorder of unknown aetiology that affects the skin, nails, oral and genital mucous membranes. Conventionally, oral LP (OLP) is diagnosed through clinical assessment and histopathological confirmation by oral biopsy.

Aim

To explore the use of time-resolved fluorescence spectroscopy (TRFS) to detect fluorescence lifetime changes between lesional OLP and perilesional normal mucosa.

Methods

In this pilot study, measurements of lesional and perilesional buccal and mouth floor mucosa were conducted in vivo with a TRFS system. Histopathological findings were consistent with OLP in 8 out of 10 patients biopsied. Two patients with histopathological diagnoses of frictional hyperkeratosis and oral candidiasis, respectively, were excluded from the study.

Results

Our preliminary data show that lifetime values in the 360–560 nm spectral range indicate a significant differentiation between normal and diseased tissue. In contrast to the standard oral biopsy procedure, this technique is noninvasive, painless, time-efficient and safe.

Conclusions

Future studies are needed to better elucidate the diagnostic capability of TRFS and to further explore the sources of fluorescence contrast. This pilot study suggests that, based on fluorescence lifetime parameters, TRFS is a very promising technology for the development of a novel OLP diagnostic technique.

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Scholar : ΓΛΩΣΣΙΤΙΣ - νέα αποτελέσματα

Mastering Healthcare Terminology-E-Book

BJ Shiland - 2018

Page 1. 6THEdmon Betsy J. Shiland º *~ MASTER NG HEALTHCARE TERMINOLOGY
Page 2. YOU'VE JUST PURCHASED MORE A TEXTBOOK! THAN Evolve Student
Resources for Shiland: Mastering Healthcare Terminology …

[HTML] Nutritional Anemia in Elderly Patients of Developed Countries

E Andrès - Current Topics in Anemia, 2018

… Iron deficiency is responsible for changes in hair (hair loss), nails (koilonychias), glossitis,
dermatitis herpetiformis, photodermatitis, restless legs syndrome, and/or Plummer's syndrome
[32]. Neuropsychiatric manifestations, Digestive manifestations, Other manifestations …

Geriatric Pain

KD Candido - Fundamentals of Pain Medicine, 2018

… Niacin (vitamin B-3) deficiency can cause pellagra, while folate loss leads to diarrhea, weight
loss, palpitations, anemia, and behavioral disorders. Untreated niacin deficiency is associated
with glossitis, light sensitivity, aggression, weakness, ataxia, and osteoporosis [10] …

[HTML] Iron Deficiency Anemia in Children

J Roganović, K Starinac - Current Topics in Anemia, 2018

… Slowly progressive paleness may sometimes be missed, but anemia also produces
nonspecific pallor of the mucous membranes. Signs of epithelial tissues that may be
associated with IDA are koilonychia, glossitis, and angular stomatitis …

Normoglycemic glucagonoma syndrome associated with necrolytic migratory erythema

R Feldmann, S Wahl, A Steiner - Journal of the European Academy of Dermatology and …

… The glucagonoma syndrome includes NME, glossitis, cheilitis, venous thrombosis,
hyperglycagonaemia, diabetes mellitus, anaemia, weight loss and neuropsychiatric disorders.
Apart from NME, the manifestations are non specific, accounting for a frequent diagnostic delay …

[PDF] Fundamental Concept of Psychosomatic Disorders: A Review

H Nisar, R Srivastava

… CLASSIFICATION OF ORAL PSYCHOSOMATIC DISEASES In 1980 Mc. Carthy PL and
Shklar.G. classified the oral psychosomatic disorders as follows- 1. Oral psychosomatic diseases
Lichen planus Aphthous ulcers Stomatitis Areata Migrans and glossitis …

[HTML] The imprint of salivary secretion in autoimmune disorders and related pathological conditions

KR Bhattarai, R Junjappa, M Handigund, HR Kim… - Autoimmunity Reviews, 2018

Xerostomia is a state of oral dryness associated with salivary gland dysfunction and is induced
by stress, radiation and chemical therapy, various systemic and.

 

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Scholar : intitle:laryngeal - new results

Oncologic and functional outcomes of pretreatment tracheotomy in advanced laryngeal squamous cell carcinoma: A multi-institutional analysis

SA Byrd, MJ Xu, LM Cass, DJ Wehrmann, M Naunheim… - Oral Oncology, 2018

Abstract Objectives Describe the influence of pretreatment tracheotomy and treatment
modality (surgical versus non-surgical) on oncologic and functional outcomes. Materials and
methods Retrospective study of previously untreated advanced-stage laryngeal squamous

[HTML] Outcomes of Onabotulinum Toxin A Treatment for Adductor Spasmodic Dysphonia and Laryngeal Tremor

PN Patel, EK Kabagambe, JC Starkweather, M Keller… - JAMA Otolaryngology–Head …, 2018

Importance The relative outcomes of onabotulinum toxin A injections for treatment of
adductor spasmodic dysphonia (ADSD), ADSD with lateral laryngeal tremor (ADSD+ LT),
and lateral LT without ADSD are unclear. Objective To compare the outcomes of

Laryngeal ultrasound detects a high incidence of vocal cord paresis after aortic arch repair in neonates and young children

MGY Lee, J Millar, E Rose, A Jones, D Wood… - The Journal of Thoracic and …, 2018

Abstract Objectives To determine (1) the incidence of vocal cord paresis (VCP) after
neonatal aortic arch repair/Norwood-type procedure, and (2) the effectiveness of non-
invasive laryngeal ultrasound in detecting VCP compared with gold standard invasive

Comparison of laryngeal morbidities with modified reinforced silicone tube intubation guided over a bougie vs. a guidewire: novel assessment with voice analysis

T Ponnusamy, P Kundra, P Rudingwa… - Anaesthesia, 2018

Summary Semi-rigid flexible introducer-guided tracheal intubation is associated with
pharyngolaryngeal morbidities. We compared the practice of railroading a newly described
modified reinforced silicone tracheal tube with a built-in guide channel in its wall over a non-

Dysphagia and laryngeal pathology in post-surgical cardiothoracic patients

A Miles, N McLellan, R Machan, D Vokes, A Hunting… - Journal of Critical Care, 2018

Purpose Cardiothoracic surgery is known to result in dysphagia and laryngeal injury. While
prevalence has been explored, extent, trajectory and longevity of symptoms are poorly
understood. This retrospective, observational study explored dysphagia and laryngeal injury

Laryngeal ultrasound for the diagnosis of laryngomalacia in infants

S Friedman, E Sadot, G Gut, K Armoni Domany… - Pediatric Pulmonology, 2018

Methods A prospective blind study of consecutive infants referred for FLB due to congenital
stridor with unknown cause. The presence of arytenoids adduction on LUS during
inspiration was used to diagnose laryngomalacia. LUS was followed by FLB under

Computational Models of Laryngeal Aerodynamics: Potentials and Numerical Costs

H Sadeghi, S Kniesburges, M Kaltenbacher… - Journal of Voice, 2018

Summary Human phonation is based on the interaction between tracheal airflow and
laryngeal dynamics. This fluid-structure interaction is based on the energy exchange
between airflow and vocal folds. Major challenges in analyzing the phonatory process in-

Meta-analysis of the effects between endotracheal intubation and laryngeal mask airway for patients with out-of-hospital cardiac arrest

X Tao, W Gu, X Liu, K Dong, Y Wang, S Ding - Zhonghua wei zhong bing ji jiu yi xue, 2018

OBJECTIVE: To comprehensively evaluate the resuscitation effect of endotracheal
intubation (ETI) ventilation and laryngeal mask airway (LMA) for out-of-hospital cardiac
arrest (OHCA). METHODS: Databases such as Cochrane Library, PubMed, Embase, Ebsco,

[PDF] PROSEAL LARYNGEAL MASK AIRWAY INSERTION IN CHILDREN; ACOMPARATIVE STUDY OF'DIGITAL TECHNIQUE'WITH'BOUGIE GUIDED TECHNIQUE'OF …

A Arunsundar, M Mahendran, D Sudhakaran - INDIAN JOURNAL OF APPLIED …, 2018

Background: Proseal Laryngeal mask airway (ProSeal™ LMA) is an advanced supraglottic
airway device which has an additional port for gastric suctioning. We conducted a
Comparative study of two techniques of insertion of ProSeal™ LMA in children. Digital

Drawing the krtań: Laryngeal alternations in Polish

A Lamont - Proceedings of the Annual Meetings on Phonology, 2018

Abstract Polish exhibits the cross-linguistically common processes of final devoicing and
voice assimilation. Notably, these target not only obstruents and obstruent clusters, but also
certain obstruent-sonorant clusters. This paper argues for an analysis in Harmonic Serialism

Comparison of inhalational vital capacity induction with sevoflurane to intravenous induction with propofol for insertion of laryngeal mask airway in adults: A …

V Udaybhaskar, A Singam, H Dodeja, K Taksande - 2018

Background: Since the development of laryngeal mask airway (LMA) by Dr. Brain, it is
extensively used for airway management; satisfactory insertion of LMA requires
administration of an induction agent and suppression of airway reflexes. Among intravenous

[PDF] Management of the Recurrent Laryngeal Nerve at the Ligament of Berry: Implications for the patient, endocrinologist and surgeon

N Hales

"I have noticed in operations of this kind, which I have seen performed by others upon the
living, and in a number of excisions, which I have myself performed on the dead body, that
most of the difficulty in the separation of the tumor has occurred in the region of these

Evaluation of treatment outcomes in patients with supraglottic laryngeal cancer in Ontario, Canada: A population‐based study

SF Hall, RJ Griffiths - Head & Neck

Background Supraglottic laryngeal carcinoma has an entirely different etiology, clinical
presentation, and prognosis compared to glottis cancer but the only evidence for the use of
concurrent chemotherapy with radiotherapy (CRT) is the 5.4% 5-year improvement in overall

 

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