From bingeing to cutting: the substitution of a mal-adaptive coping strategy after bariatric surgery

Abstract

Background

An increase in self-harm emergencies after bariatric surgery have been documented, but understanding of the phenomenon is missing.

Case presentation

The following case report describes a 26-year-old woman with obesity, who initiated self-harm behaviour after bariatric surgery. The patient reported that the self-harm was a substitute for binge eating, which was anatomically impeded after bariatric surgery.

Pre-surgical psychosocial assessment revealed Anorexia Nervosa in youth, which had later migrated to Binge Eating Disorder. At the time of surgery, the patient was not fulfilling the diagnostic criteria for Binge Eating Disorder because of a low frequency of binges. The remaining binges occurred when experiencing negative affect.

Conclusions

Previous eating disorder pathology is an important consideration in pre-surgical assessments. For patients with affect-driven pre-surgical Binge Eating Disorder, therapeutic intervention before and after bariatric surgery could be indicated in order to secure the development of adaptive coping strategies. Furthermore, body weight as the only outcome measure for the success of surgery seems insufficient.

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Cosmetics, Vol. 5, Pages 58: Agro-Industrial By-Products and Their Bioactive Compounds—An Ally against Oxidative Stress and Skin Aging

Cosmetics, Vol. 5, Pages 58: Agro-Industrial By-Products and Their Bioactive Compounds—An Ally against Oxidative Stress and Skin Aging

Cosmetics doi: 10.3390/cosmetics5040058

Authors: Panagiotis E. Simitzis

The increased consumer awareness towards hazards related with sun exposure has given a boost in the cosmetics industry and particularly the sun care market. Human skin is continually being threatened by the UV irradiation present in sunlight and acute UV exposure leads to skin photoaging. Cosmetic and/or dermatological applications include several bioactive compounds that contribute to the regulation of epidermal homeostasis by providing protection against solar radiation and improving the antioxidant activity of epidermis. Plant extracts are sources of active ingredients with intense therapeutic properties, and the topical application or oral intake of these compounds could ameliorate skin condition. Nowadays, there is a growing demand for the application of the bioactive agents contained in agro-industrial byproducts in sun care products, since many of them have shown promising properties as skin photoprotectants. However, well-conducted clinical studies are required to prove their safety and efficacy before they could be regularly used. Environmentally friendly extraction and sustainable techniques are therefore under examination for recovering such compounds from agro-industrial byproducts and converting them into innovative high-value natural ingredients used in cosmetic formulations.

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Cosmetics, Vol. 5, Pages 57: Hidden Metals in Several Brands of Lipstick and Face Powder Present on Polish Market

Cosmetics, Vol. 5, Pages 57: Hidden Metals in Several Brands of Lipstick and Face Powder Present on Polish Market

Cosmetics doi: 10.3390/cosmetics5040057

Authors: Elżbieta Łodyga-Chruścińska Anna Sykuła Marzenna Więdłocha

Cosmetics still retain their brilliant effect, but public concern about their toxicity has become a hot issue. Trace amounts of toxic heavy metals can be either intentionally added to cosmetics or present as impurities in the raw materials. We therefore assessed the levels of lead, nickel, copper, zinc and iron in six brands of lipstick and six brands of cosmetic powder that are widely available in local Polish markets. The cosmetics were digested and analyzed for the metals using flame atomic absorption spectrophotometry. Lead and nickel were found in some powders, but none in lipstick samples. This study revealed that the levels of these metals were higher than the specifications reported in the literature data. On the other hand, the copper content was determined at the level of 435 mg/kg in one sample of powder and at 75.92 mg/kg in one lipstick. Iron levels ranged from 0 to 12,168.57 mg/kg depending on the brand of powder or lipstick, and were generally higher in powders. Zinc was detected in the range of 1.73–488.31 mg/kg in all 12 samples. The results lead to the conclusion that constant control of metallic content in lipsticks, powders and other facial cosmetics should be seriously considered.

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PET imaging of [ 11 C]PBR28 in Parkinson’s disease patients does not indicate increased binding to TSPO despite reduced dopamine transporter binding

Abstract

Purpose

To examine the hypothesis that cerebral binding to the 18 kDa translocator protein (TSPO), a marker of microglia activation, is elevated in Parkinson's disease (PD), and to assess the relationship between brain TSPO binding and dopaminergic pathology in PD.

Methods

The radioligand [¹¹C]PBR28 was used for quantitative assessment of brain TSPO in 16 control subjects and 16 PD patients. To analyse the relationship between dopaminergic pathology and brain TSPO binding, PET studies of the dopamine transporter (DAT) were undertaken in PD patients using the DAT radioligand [¹⁸F]FE-PE2I. The total distribution volume of [¹¹C]PBR28 was quantified in nigrostriatal regions, limbic cortices and thalamus, and the binding potential of [¹⁸F]FE-PE2I was quantified in nigrostriatal regions.

Results

Based on genotype analysis of the TSPO rs6971 polymorphism, 16 subjects (8 control subjects and 8 PD patients) were identified as high-affinity binders, and the remaining subjects were identified as mixed-affinity binders. A two-way ANOVA showed a strong main effect of TSPO genotype on the cerebral binding of [¹¹C]PBR28, whereas no statistically significant main effect of diagnostic group, or a group by genotype interaction was found for any of the regions analysed. [¹⁸F]FE-PE2I PET studies in patients indicated a marked reduction in nigrostriatal binding to DAT. However, no correlations between the binding parameters were found for [¹¹C]PBR28 and [¹⁸F]FE-PE2I.

Conclusion

The findings do not support the hypothesis of elevated cerebral TSPO binding or a relationship between TSPO binding and dopaminergic pathology in PD.

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2018 Sidney H. Ingbar Distinguished Lectureship Award to Be Given to Anthony N. Hollenberg, MD, at American Thyroid Association’s Annual Meeting

October 1, 2018—The American Thyroid Association (ATA) is pleased to announce that the 2018 Sidney H. Ingbar Distinguished Lectureship Award recipient will be Dr. Anthony N. Hollenberg, currently Professor and Chief of the Division of Endocrinology, Metabolism, and Diabetes at Beth Israel Hospital, Boston, as well as Physician in Endocrinology at Beth Israel Deaconess Medical Center (BIDMC).

The Ingbar Award recognizes an established investigator who has made outstanding contributions to thyroid-related research over many years. The award honors the memory of Dr. Sidney H. Ingbar, a brilliant innovator who was once Chief of the Beth Israel Thyroid Unit, a position Dr. Hollenberg now holds. The medal is conferred at the ATA Annual Meeting, held this year from October 3 to 7 in Washington, DC. On Friday, October 5, at 1 pm, Dr. Hollenberg will deliver the Sidney H. Ingbar Distinguished Award Lecture, titled "New Insights into Thyroid Hormone Action."

Dr. Hollenberg is recognized internationally for his consistent research contributions in studies of the molecular action of thyroid hormones. He was among the first to identify that thyrotropin-releasing hormone (TRH) neurons in the hypothalamus serve as integrators of metabolic input, setting thyroid hormone levels within the context of body weight. He was also among the first to identify the role of specific co-repressors in negative regulation by the thyroid and helped to establish the idea that hormone sensitivity is due to the quantity of co-repressors present. He has had an independent research laboratory at Beth Israel Hospital since 1993 and been funded continuously by the NIH since 1995. In addition, he founded the Thyroid Nodule Clinic at BIDMC 16 years ago to enable clinicians, radiologist, and cytologist to practice together, enhancing clinical care for patients with nodules.

In addition to groundbreaking research in thyroid hormone receptor action and function, Dr. Hollenberg has more recently begun a new program in his laboratory focused on the development of functioning thyroid follicular cells from embryonic stem cells, working in conjunction with the Kotton lab at Boston University School of Medicine.

Dr. Hollenberg received his MD from the Faculty of Medicine at the University of Calgary, Alberta, after earning his AB degree cum laude in biochemical sciences from Harvard College. He spent his internship and residency at BIDMC, after which he was Chief Medical Resident there for one year. Overlapping that appointment and continuing after it, he was Clinical and Research Fellow in Endocrinology as Massachusetts General Hospital (MGH). At the same time, he has risen from Instructor to Professor of Medicine at Harvard Medical School and has held—and continues to hold—numerous administrative positions at the local, national, and international levels. He has been a welcomed speaker at symposia, seminars, society meetings, and medical schools around the world for almost 20 years.

In addition to his research and academic activities, Dr. Hollenberg has served in an editorial capacity for the New England Journal of Medicine, Proceedings of the National Academy of Sciences, Endocrinology, Journal of Biological Chemistry, and many other journals and been on the editorial boards of Endocrinology and Molecular Endocrinology. Over 100 publications and book chapters have Dr. Hollenberg's signature and he has mentored and trained well over 100 graduate students and laboratory trainees. He received the ATA's Van Meter Award and the British Endocrine Society's Pitt Rivers Award, among others.

Through his sophisticated research, innovations, public speaking, and publications, Dr. Hollenberg has contributed significantly and continuously to the well-being of those with thyroid disease. That commitment, combined with his dedication to his patients and students, makes him a very worthy recipient for the highly sought after and prestigious, Sidney H. Ingbar Distinguished Award.

 ###

The American Thyroid Association (ATA) is the leading worldwide organization dedicated to the advancement, understanding, prevention, diagnosis, and treatment of thyroid disorders and thyroid cancer. ATA is an international membership medical society with over 1,700 members from 43 countries around the world. Celebrating its 95^th anniversary, the ATA continues to deliver its mission of being devoted to thyroid biology and to the prevention and treatment of thyroid disease through excellence in research, clinical care, education, and public health.  These efforts are carried out via several key endeavors:

•  The publication of the highly regarded professional journals Thyroid, Clinical Thyroidology, and VideoEndocrinology
• Annual scientific meetings
• Biennial clinical and research symposia
• Research grant programs for young investigators
• Support of online professional, public, and patient educational programs
• Development of guidelines for clinical management of thyroid disease and thyroid cancer

 The ATA promotes thyroid awareness and information online through Clinical Thyroidology for the Public and extensive, authoritative explanations of thyroid disease and thyroid cancer in both English and Spanish. The ATA website serves as the clinical resource for patients and the public who look for reliable information on the Internet. Every fifth year, the American Thyroid Association joins with the Latin American Thyroid Society, the European Thyroid Association, and the Asia and Oceania Thyroid Association to cosponsor the International Thyroid Congress (ITC).

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2018 Paul Starr Award to Be Given to Scott A. Rivkees, MD, at American Thyroid Association’s Annual Meeting

October 1, 2018—The American Thyroid Association (ATA) is pleased to announce that the 2018 Paul Starr Award recipient and lecturer will be Dr. Scott A. Rivkees, Professor and Chair, as well as Nemours Eminent Scholar, at the University of Florida Department of Pediatrics. Dr. Rivkees is also Physician-in-Chief at Shands Children's Hospital in Gainesville, Academic Chair of Pediatrics at Arnold Palmer Hospital in Orlando, and University of Florida Chair of Pediatrics at Studer Family Children's Hospital at Sacred Heart in Pensacola.

The Starr Award is presented to an outstanding contributor to clinical thyroidology. At the ATA Annual Meeting in Washington, DC, Dr. Rivkees will deliver the Paul Starr Award Lecture at 1:00 pm on October 4, 2018, on "Unmasking the Problems With Antithyroid Medication Safety."

Dr. Rivkees earned his BS in biochemistry from Cook College at Rutgers University and his MD from New Jersey Medical School. Thereafter, he was a Resident in Pediatrics at Massachusetts General Hospital (MGH) and Clinical Fellow in Pediatrics at Harvard Medical School (HMS), then a Clinical Fellow in Pediatric Endocrinology at both locations. While working as a Postdoctoral Fellow in Neuroscience—again at both locations—Dr. Rivkees was also a Research Fellow at MGH. After his postdoc, he was appointed Instructor in Pediatrics at HMS and Assistant in Pediatrics at MGH, followed by Assistant Professor of Pediatrics at HMS and Associate Professor Pediatrics at Indiana University and Yale University. After receiving tenure at Yale, he became director of the Yale Child Health Research Center, Professor of Pediatrics, Chief of the Section of Developmental Endocrinology and Biology, and Associate Chair of Yale Pediatrics for Research, all at the same time. From there he moved to his current appointments in Florida.

Dr. Rivkees's important contributions have focused on pediatric thyroidology, but also on thyroidology more generally. He made public the dangers—especially the onset of liver failure—associated with the use of the medicine propylthiouracil, which resulted in worldwide changes in the treatment of hyperthyroidism. Through his research, clinical work, and publications, he was responsible for changing the way children with juvenile-acquired hypothyroidism are treated. He wrote many papers concerning the risks and benefits of using radioactive iodine in children with thyroid disease, predating the ATA's own guidelines on treating pediatric thyroid cancer. And he started the first Pediatric Thyroid Cancer Program in the US, at Yale University.

Another area of Dr. Rivkees's research evaluated the risks of antithyroid medications to both mother and fetus, which led to findings that are now incorporated into the ATA guidelines for managing hypothyroidism during pregnancy.

Dr. Rivkees has written over 230 articles, chapters, and editorials. He is Editor-in-Chief of the International Journal of Pediatric Endocrinology and a member of the American Society for Clinical Investigation. He has been named "One of America's Best Doctors" and "One of America's Top Pediatricians," as well as "Physician of the Year" by the CARES Foundation. Dr. Rivkees has served on numerous panels, advisory boards, editorial boards, and symposia and in 2012 was named a Fellow of the American Academy for the Advancement of Science. He holds one patent, with three more pending.

Over the past three-plus decades, Dr. Rivkees has demonstrated repeatedly his dedication to clinical thyroidology, improving the care of infants, children, and adolescents worldwide. That commitment, combined with his dedication to his patients and students, makes him a very worthy recipient for the highly sought after and prestigious, 2018 Paul Starr Award, the first ever given to a pediatric endocrinologist.

 ###

The American Thyroid Association (ATA) is the leading worldwide organization dedicated to the advancement, understanding, prevention, diagnosis, and treatment of thyroid disorders and thyroid cancer. ATA is an international membership medical society with over 1,700 members from 43 countries around the world. Celebrating its 95^th anniversary, the ATA continues to deliver its mission of being devoted to thyroid biology and to the prevention and treatment of thyroid disease through excellence in research, clinical care, education, and public health.  These efforts are carried out via several key endeavors:

•  The publication of the highly regarded professional journals Thyroid, Clinical Thyroidology, and VideoEndocrinology
  
• Annual scientific meetings
• Biennial clinical and research symposia
• Research grant programs for young investigators
• Support of online professional, public, and patient educational programs
  
• Development of guidelines for clinical management of thyroid disease and thyroid cancer

 The ATA promotes thyroid awareness and information online through Clinical Thyroidology for the Public and extensive, authoritative explanations of thyroid disease and thyroid cancer in both English and Spanish. The ATA website serves as the clinical resource for patients and the public who look for reliable information on the Internet. Every fifth year, the American Thyroid Association joins with the Latin American Thyroid Society, the European Thyroid Association, and the Asia and Oceania Thyroid Association to cosponsor the International Thyroid Congress (ITC).

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2018 Lewis E. Braverman Distinguished Award to Be Presented to R. Michael Tuttle, MD, at American Thyroid Association’s Annual Meeting

October 1, 2018—The American Thyroid Association (ATA) announces with pleasure that the 2018 Lewis E. Braverman Distinguished Award recipient will be Dr. R. Michael Tuttle, currently Clinical Director of the Endocrinology Service and Attending Physician at Memorial Hospital for Cancer and Allied Diseases in New York City. Academic positions include Member, at Memorial Sloan Kettering Cancer Center (MSKCC) and Professor of Medicine at Weill Medical College of Cornell University, both in New York City.

The Braverman Distinguished Award is presented annually to an individual who: demonstrates excellence and passion for mentoring fellows, students, and junior faculty; has a long history of productive thyroid research; and is devoted to the ATA. Dr. Tuttle will give the Braverman Lecture, entitled "Common Clinical Thyroid Cancer Questions in Need of Better Answers" on October 6 at 10:45 am, during the ATA Annual Meeting, which is held this year from October 3 to 7 in Washington, DC.

Dr. Tuttle has demonstrated his teaching and mentoring excellence in training medical students, interns, residents, and fellows during his entire career. Many of his past fellows have gone on to national and international prominence in thyroid cancer research, treatment, and education. To quote one of his fellows, now an assistant professor from Saudi Arabia, he learned from Dr. Tuttle that "it is OK to change my practice and admit to do so if studies proved new evidence…. I learned how to communicate with colleagues and other working staff in a delightful way. He was always considerate and open to new ideas." Another cancer physician writes that after his fellowship with Dr. Tuttle he "gave multiple lectures around the country [Israel] that helped change the 'one size fits all' approach to a more risk-adapted, personalized approach." Through hundreds of invited lectures, meetings, and grand rounds, as well as his almost 300 publications, Dr. Tuttle has reached even more medical students, fellows, and peers with his emphasis on minimalism in treatment.

Dr. Tuttle's research has had major clinical impact over the years on the care of thyroid cancer patients. His laboratory's work confirmed that a recurrence staging system effectively predicts the risks of recurrence and persistent disease and that these risk assessments can be used productively to tailor follow-up recommendations for individual patients on a case-by-case basis, rather than using generalized treatment methods. Another of his mentees comments, "Thanks to everything learned with Dr. Mike Tuttle…the quality of life of patients with diagnosis and thyroid cancer in Chile is significantly higher."

An active member of the ATA since 1997, Dr. Tuttle has served on multiple committees, such as Clinical Affairs, Standards of Care, and Membership, among others. He was Program Chair of the 2014 Annual Meeting and a member of the Board of Directors from 2007 to 2011. He was key in drafting the ATA Guidelines on the Management of Thyroid Nodules and Thyroid Cancer and continues to be active on that committee, and he currently is Chair of the ATA's Medullary Thyroid Cancer Registry Consortium. In addition, Dr. Tuttle has been a reviewer for the ATA's journal Thyroid (as well as many other journals) and was Associate Editor of Thyroid from 2013 through 2015. He has attracted many new members to the ATA with his great enthusiasm for the study of thyroid disease.

Dr. Tuttle earned his BS in biology magna cum laude from Northern Kentucky University and his MD cum laude from the University of Louisville School of Medicine, KY. He spent his internship and residency in Internal Medicine at Dwight David Eisenhower Army Medical Center, Augusta, GA, where he was awarded "Outstanding Graduating Resident." He held a Clinical Fellowship in endocrinology, a Research Fellowship in endocrinology and molecular biology, and then was Staff Endocrinologist, all at Madigan Army Medical Center in Tacoma, WA. His hospital positions thereafter were at Walter Reed Army Medical Center and then the Department of Medicine, Memorial Hospital for Cancer and Allied Disease, NYC, where he is now Attending Physician and Clinical Director of the Endocrinology Service. At the same time, his teaching and research positions have led him through the professional ranks at Memorial Sloan Kettering Cancer Center and the Weill Medical College of Cornell University.

Dr. Tuttle continues to leave a significant impact in the thyroid cancer field through his valuable mentoring, research, and contributions to the ATA.  That commitment, combined with his dedication to his patients and students, makes him a very worthy recipient for the highly sought after and prestigious, 2018 Lewis E. Braverman Distinguished Award.

 ###

The American Thyroid Association (ATA) is the leading worldwide organization dedicated to the advancement, understanding, prevention, diagnosis, and treatment of thyroid disorders and thyroid cancer. ATA is an international membership medical society with over 1,700 members from 70 countries around the world. Celebrating its 95^th anniversary, the ATA delivers its mission of being devoted to thyroid biology and to the prevention and treatment of thyroid disease through excellence in research, clinical care, education, and public health. 

These efforts are carried out via several key endeavors:

• The publication of the highly regarded professional journals Thyroid^®, Clinical Thyroidology^®, and VideoEndocrinology
• Annual scientific meetings
• Biennial clinical and research symposia
• Research grant programs for young investigators
• Support of online professional, public, and patient educational programs
• Development of guidelines for clinical management of thyroid disease and thyroid cancer

 Further information about the ATA^® annual meeting can be found https://www.thyroid.org/88th-annual-meeting-ata/ and research grants program https://www.thyroid.org/media-main/ and patient information https://www.thyroid.org/thyroid-information/.  The ATA promotes thyroid awareness and information online through Clinical Thyroidology^® for the Public and extensive, authoritative explanations of thyroid disease and thyroid cancer in both English and Spanish. The ATA website serves as the clinical resource for patients and the public who look for reliable information on the Internet. Every fifth year, the American Thyroid Association joins with the Latin American Thyroid Society, the European Thyroid Association, and the Asia and Oceania Thyroid Association to cosponsor the International Thyroid Congress (ITC).

 

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The American Thyroid Association holds its 88th Annual Meeting at the Marriott Marquis, Washington DC from October 3-7, 2018

The 88^th Annual Meeting of the American Thyroid Association (ATA) is almost here!! On behalf of the program committee, we look forward to welcoming you and your guests to our ATA annual meeting to be held October 3-7, 2018 at the Marriott Marquis Washington DC. This year the program committee, comprised of experts of all thyroid disciplines, has worked tirelessly to develop a program featuring the latest advances in basic/ translational and clinical thyroidology (www.thyroid.org). Meeting registration is on track to generate the highest attendance we have ever had for an ATA meeting. Washington, DC is a world-class destination with many stellar cultural, musical and museum attractions (within walking distance of the headquarters' hotel) available to attendees and their families.

New Programs This Year

This year the program will feature a wide variety of primary lectures, symposia and discussion-debates/meet the professor workshops that have been highly rated in the past along with several new sessions we hope to be of great interest. The first is the very first ATA international symposium – the ATA Latin American Satellite Symposium from 1:00 PM to 4:00 PM on Wednesday, October 3. This will represent a gathering of Latin American and ATA leaders allowing for true international interaction, networking, collaboration, the renewal of old and hopefully the development of new friendships. The international representation of the annual meeting is reflected by the over 543 abstracts submitted representing more than 38 countries.

The other new addition to the 2018 program is the 1^st Annual Advanced Practice Providers (APP) Satellite Symposium from 1:00 to 6:00 PM on Saturday, October 6.  This symposium reflects the growing membership within the ATA of advanced practice providers.  Reflecting this, the APP symposium will bring together the spectrum of healthcare professionals comprising the clinical "thyroid team"; focusing on all aspects of clinical management of thyroid disease, including nurse practitioners, clinical nurse specialists, advanced degree nurses and physician assistants.

Opening Day

Of interest in our pre-meeting programming is the ATA Endocrine Neck Advanced Ultrasound Course co-chaired by Kevin Brumund and Susan Mandel on Wednesday, October 3 and the E. Chester Ridgway Trainee Conference, an extensive clinical and basic training program co-chaired by Jacqueline Kung and Jennifer Sipos (for both these pre-congress programs preregistration is required, and seating is limited). On the evening of October 3, the annual meeting will kick off with our traditional Year in Thyroidology review featuring three leaders to discuss and interpret the top recent literature published in basic, clinical and surgical thyroidology. Christine Spitzweg, Virginia Sarapura, and Amy Chen will present summaries of the most notable studies in each of their respective fields. This remains a highly anticipated opening session and will be followed by the

This year, we have two distinguished speakers who will be presenting timely and novel plenary lectures: Dr. Kevin Harold from Yale University speaking on The Role of the Microbiome in Thyroid Autoimmunity and Dr. Timothy Chan from MSKCC discussing Antitumor Immunology and Immune therapies for Advanced Thyroid Cancer. Notable symposia include: Clinical Symposium: Iodine and Health, chaired by Elizabeth Pearce with speakers Jonathan Gorstein, Sarah C. Bath and Angela M. Leung; Basic Symposium: Genetic Landscapes on Advanced Thyroid Cancers chaired by Laura Boucai, with speakers Mingzhao Xing, Matthew D. Ringel and James A. Fagin. The highly anticipated Arthur Bauman Clinical Symposium will focus on cytologically indeterminate thyroid nodules and the role (and controversies) of molecular markers in their management strategies.

Awards remain an important part of the meeting, with recognitions being held for the following:

• The ATA will announce the recipient of the Van Meter Award on Thursday, October 4^th in recognition of outstanding contributions to thyroid research.
• Scott A. Rivkees is the recipient of the Paul Starr Award, which recognizes outstanding contributions to clinical thyroidology, and will present Unmasking the Problems with Anti-Thyroid Medication Safety.
• The ATA Distinguished Service Award will be presented to David H. Sarne for his outstanding contributions to the society.
• The John B. Stanbury Thyroid Pathophysiology Medal will be awarded to Marvin C. Gershengorn.
• The Clark T. Sawin Historical Presentation on the Treatment of Hypothyroidism – from Animal Extracts to Current Controversies will be moderated by Peter Kopp, with panelists to include John Morris, Valerie Anne Galton, Jacqueline Jonklaas and Stephen LaFranchi.
• The Sidney H. Ingbar Distinguished Awardee, an established investigator who has made major contributions to thyroid-related research over many years, is Anthony Hollenberg who will speak on New Insights into Thyroid Hormone Action.
• The Lewis E. Braverman Distinguished Lectureship Award established in 2011 to recognize an individual who has demonstrated excellence and passion for mentoring fellows, students and junior faculty is being presented by R. Michael Tuttle on Common Clinical Thyroid Cancer Questions in Need of Better Answers.

Based on the success of last year's meeting, we are pleased to again offer the ATA Pediatric Thyroid Forum Satellite Symposium – Current state and Future Directions, co-chaired by Andrew Bauer and Catherine Dinauer taking place Saturday, October 6.

Mainstays of the Annual meeting, Discussion-Debates/Meet The Professor Workshops have shown high registration numbers thus far, including Locally Advanced Thyroid Cancer in the Era of TKIs, Endocrine and Nuclear Medicine – Controversies, Consensus and Collaboration in the use of RAI therapy in DTC, Understanding of Thyroid Pathology and Cytology for Endocrinologists and Surgeons, Thyroid Disease and Pregnancy, Medullary Thyroid Cancer – Updates on Detection, Management and Postoperative follow-up, RET translational symposium – 25 year anniversary of RET and Precision Medicine in Thyroid Cancer 2018.

Surgical programming

The surgical component of this year's annual meeting will be strong with participation of our many surgeon members representing numerous thyroid surgical societies. Sessions of interest to surgeons include the Role of molecular markers and evaluation of thyroid nodules chaired by Jennifer Sipos, a session on Medullary Thyroid Cancer chaired by Rich Wong, a session on Patient Reported Outcomes in Thyroid Cancer Treatment chaired by Megan Haymart and Jeffrey Garber and a special Surgical Symposium on Multidisciplinary Management of Graves' Disease 2018 chaired by Rosemary Metzger as well as a Thyroid Cancer Tumor Board session chaired by Catherine Sinclair and a session on Locally Advanced Thyroid Cancer Management in the Era of TKIs moderated by Wendy Sacks. We will again have a VideoEndocrinology session on Risk stratification of thyroid cancer chaired by William Barry Inabnet and David Terris.

ATA Governance and Constituency-building

The ATA annual meeting is a great time to work for the ATA within its committee structure and to get time to engage directly with colleagues and trainees over a poster or by discussion of an oral abstract presentation. Meet presenters and attendees with backgrounds in basic and clinical thyroid research, general endocrinology, otolaryngology, endocrine surgery, pediatric endocrinology, medical oncology, nuclear medicine, laboratory sciences, industry, pathology, cytology, advanced practice providers and allied health disciplines. Meet with pharmaceutical, device and technology sponsors and our patient support groups at the 2018 ATA Thyroid EXPO. ATA committee meetings will be held Wednesday, October 3, the Women in Thyroidology Networking Reception also Wednesday, October 3 the annual ATA Business Meeting will be held Thursday, October 4.

CME and MOC credits available

This year through meeting attendance one may earn a maximum of 23.50 AMA PRA Category 1 Credits™ and in addition through a new Maintenance of Certification (MOC) program attendees may earn up to 23.50 medical knowledge MOC points in the American Board of Internal Medicine MOC program through their program and activity reporting system and ACCME.

 

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2018 Distinguished Service Award to Be Given to David H. Sarne, MD, at American Thyroid Association’s Annual Meeting

October 1, 2018—The American Thyroid Association (ATA) is pleased to announce that the 2018 Distinguished Service Award recipient will be Dr. David H. Sarne, currently Clinical Associate in the Department of Medicine at the University of Chicago.

The Distinguished Service Award recognizes an ATA member who has made important and continuing contributions to the Association. The award will be conferred during the Presentation of Awards, beginning at 4:00 pm on October 4 during the ATA Annual Meeting, held this year from October 3 to 7 in Washington, DC.

Dr. Sarne received his MD with honors from the University of Michigan Medical School, after receiving his BS with highest distinction in Psychology and Zoology from the University of Michigan. He spent his internship and residency with the University of California Hospitals and Clinics in San Francisco and then became a Fellow in the Section of Endocrinology, Department of Medicine, at the University of Chicago. After three years as an Assistant Professor of Medicine at the University of Chicago, he moved to the University of Illinois Medical Center, where he rose to Professor. In 2012 he returned to the University of Chicago in his current position.

He has specialized in thyroid disorders, including hyperthyroidism, nodules, and thyroid cancer. As such, he has received regular funding for research efforts and has been an invited speaker at universities, association meetings, and conferences. Dr. Sarne has been the primary or a significant contributor to over 50 articles, book chapters, and other publications and has served as a manuscript reviewer for numerous medical journals, including JAMA, the New England Journal of Medicine, Thyroid, and Endocrinology, among others. He has repeatedly been named one of the "Best Doctors in America" and received scholarships, prizes, and awards throughout his academic and practice years.

Most important for the Distinguished Service Award, Dr. Sarne served on a variety of committees for the ATA between 1987 and 2017, including the Education Committee, the Distinguished Service Committee, the Awards Committee, the Annual Meeting Organizing Committee, and the Finance and Audit Committee—for the last of which he was Chair for 13 years. And he has twice served on the ATA's Board of Directors as Treasurer and member of the Executive Committee, first for a period of 7 years and most recently for 2 more years.

Dr. Sarne's tremendous commitment of time and energy to the Association over the past 30 years has helped to maintain our successful operation, particularly our financial health and stability. That commitment, combined with his dedication to his patients and students, makes him a very worthy recipient for the highly sought after and prestigious Distinguished Service Award.

 ###

The American Thyroid Association (ATA) is the leading worldwide organization dedicated to the advancement, understanding, prevention, diagnosis, and treatment of thyroid disorders and thyroid cancer. ATA is an international membership medical society with over 1,700 members from 70 countries around the world. Celebrating its 95^th anniversary, the ATA delivers its mission of being devoted to thyroid biology and to the prevention and treatment of thyroid disease through excellence in research, clinical care, education, and public health. 

These efforts are carried out via several key endeavors:

• The publication of the highly regarded professional journals Thyroid^®, Clinical Thyroidology^®, and VideoEndocrinology
• Annual scientific meetings
• Biennial clinical and research symposia
• Research grant programs for young investigators
• Support of online professional, public, and patient educational programs
• Development of guidelines for clinical management of thyroid disease and thyroid cancer

 Further information about the ATA^® annual meeting can be found https://www.thyroid.org/88th-annual-meeting-ata/ and research grants program https://www.thyroid.org/media-main/ and patient information https://www.thyroid.org/thyroid-information/.  The ATA promotes thyroid awareness and information online through Clinical Thyroidology^® for the Public and extensive, authoritative explanations of thyroid disease and thyroid cancer in both English and Spanish. The ATA website serves as the clinical resource for patients and the public who look for reliable information on the Internet. Every fifth year, the American Thyroid Association joins with the Latin American Thyroid Society, the European Thyroid Association, and the Asia and Oceania Thyroid Association to cosponsor the International Thyroid Congress (ITC).

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2018 John B. Stanbury Thyroid Pathophysiology Medal to Be Awarded to Marvin C. Gershengorn, MD, at American Thyroid Association’s Annual Meeting

October 1, 2018—The American Thyroid Association (ATA) announces with pleasure that the 2018 John B. Stanbury Thyroid Pathophysiology Medal will be awarded to Dr. Marvin C. Gershengorn at the ATA Annual Meeting this week. Dr. Gershengorn is Chief of the Clinical Endocrinology Branch (formerly the Laboratory of Endocrinology and Receptor Biology) at the National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, Maryland.

The Stanbury Medal recognizes outstanding research contributions, either conceptual or technical, to the understanding of thyroid physiology or the pathophysiology of thyroid disease, that have had a major impact on research or clinical practice. The medal is traditionally conferred at the ATA Annual Meeting, held this year from October 3 to 7 in Washington, DC.

Dr. Gershengorn received his MD with honors in Biochemistry in 1971 from New York University School of Medicine after completing his BS magna cum laude at City College of the City University of New York (CUNY). He completed his internship and residency in Medicine at Strong Memorial Hospital of the University of Rochester School of Medicine and Dentistry. He became a Clinical Associate in the Clinical Endocrinology Branch of the National Institute of Arthritis, Metabolism, and Digestive Diseases at NIH, then returned to the NYU School of Medicine as Assistant Professor, then Director of the Honors Program, Associate Professor of Medicine, and Associate Professor in the Graduate School of Arts and Sciences. Moving to Cornell University Medical College and the New York Hospital, he was appointed in turn Professor of Medicine and Chief of the Division of Endocrinology and Metabolism, Professor of Physiology and Biophysics, the Abby Rockefeller Mauze Distinguished Professor of Endocrinology in Medicine, Professor of Cell Biology and Genetics, Professor of Medicine and Director of the Division of Molecular Medicine, and Director of the Molecular Medicine Training Program. At Weill Graduate School of Medical Sciences of Cornell University, Dr. Gershengorn was appointed Chair of the Program in Physiology, Biophysics, and Molecular Medicine. He joined the NIDDK in 2001 as Director of the Division of Intramural Research (Scientific Director) before his current appointment in 2008.

During his various research positions, Dr. Gershengorn has made groundbreaking scientific contributions that have increased our understanding of thyroid physiology, from the development of the first assays to measure T3 in human serum, to using lithium as an adjunct to radioiodine therapy in thyroid cancer, to fine-needle aspiration biopsy for the diagnosing thyroid nodules, to determining the gene sequence of the TRH receptor, among many others. His laboratory has been the leader in developing small-molecule, drug-like compounds that target the TSH receptors of the thyroid.

Dr. Gershengorn has received numerous awards, honors, and fellowships during his career, including both the Van Meter Award and the Sidney Ingbar Distinguished Lectureship for Outstanding Thyroid Research from the ATA, two awards from the Endocrine Society, and the NIDDK Director's Award for Translational Research. He has served on the editorial boards of journals dedicated to endocrinology, biological chemistry, and physiology and on advisory boards, review committees, and as a board director. From 1999 to 2001, Dr. Gershengorn was a Director of the ATA Board.

In addition to holding five patents, Dr. Gershengorn has shared in writing 280 journal articles since 1968.

His four decades of very productive research, teaching, writing, and continuous contributions to our understanding of the pathophysiology of thyroid disease make Dr. Gershengorn an extremely appropriate recipient of the 2018 John B. Stanbury Pathophysiology Medal.

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The American Thyroid Association (ATA) is the leading worldwide organization dedicated to the advancement, understanding, prevention, diagnosis, and treatment of thyroid disorders and thyroid cancer. ATA is an international membership medical society with over 1,700 members from 43 countries around the world. Celebrating its 95^th anniversary, the ATA continues to deliver its mission of being devoted to thyroid biology and to the prevention and treatment of thyroid disease through excellence in research, clinical care, education, and public health.  These efforts are carried out via several key endeavors:

•  The publication of the highly regarded professional journals Thyroid^®, Clinical Thyroidology^®, and VideoEndocrinology
• Annual scientific meetings
  
• Biennial clinical and research symposia
• Research grant programs for young investigators
• Support of online professional, public, and patient educational programs
  
• Development of guidelines for clinical management of thyroid disease and thyroid cancer

 The ATA promotes thyroid awareness and information online through Clinical Thyroidology for the Public and extensive, authoritative explanations of thyroid disease and thyroid cancer in both English and Spanish. The ATA website serves as the clinical resource for patients and the public who look for reliable information on the Internet. Every fifth year, the American Thyroid Association joins with the Latin American Thyroid Society, the European Thyroid Association, and the Asia and Oceania Thyroid Association to cosponsor the International Thyroid Congress (ITC).

The post 2018 John B. Stanbury Thyroid Pathophysiology Medal to Be Awarded to Marvin C. Gershengorn, MD, at American Thyroid Association's Annual Meeting appeared first on American Thyroid Association.

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Health related quality of life improves one year after parathyroidectomy in primary hyperparathyroidism: A prospective cohort study

Clinical Endocrinology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2NNWGK2

The PROCLIPI international registry of early stage Mycosis Fungoides identifies substantial diagnostic delay in most patients

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


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Effect of different sizes of bioactive glass-coated mesoporous silica nanoparticles on dentinal tubule occlusion and mineralization

Abstract

Objectives

To synthesize two different sizes of bioactive glass-coated mesoporous silica nanoparticles (BGN@MSNs) and to investigate their effects on dentinal tubule occlusion and remineralization.

Materials and methods

Two different sizes of mesoporous silica nanoparticles (MSNs) were synthesized using the Stöber method (368A, 1840A) and coated with bioactive glass nanoparticles (BGNs) using a modified quick alkali-mediated sol-gel method (368B, 1840B). Sensitive tooth disc models were prepared and divided into six groups and the following treatments were applied: group 1—no treatment, group 2—bioglass, group 3—368A, group 4—368B, group 5—1840A, and group 6—1840B. Then, five discs were selected from each group and soaked in 6 wt% citric acid to test acid resistance. Dentinal tubule occlusion and occlusion ratio were observed using field-emission scanning electron microscopy. In vitro mineralization tests using simulated body fluid solution were performed to evaluate the remineralization effect of the treatment.

Results

All samples effectively occluded the dentinal tubule and formed a membrane-like layer. After acid treatment, 1840B (group 6) exhibited the highest rate of dentinal tubule occlusion. Remineralization was observed in 368B and 1840B, and 1840B exhibited the fastest remineralization.

Conclusions

Dentinal tubule remineralization induced by the BGN@MSN biocomposite can be used to stabilize long-term prognosis in dentin hypersensitivity. The 1840B induced the most efficient remineralization, and its smaller size and larger surface area were effective for remineralization.

Clinical relevance

The BGN@MSN biocomposite with its smaller size and larger surface area was more effective for remineralization and dentinal tubule sealing.

https://ift.tt/2N9CjBT

Self-report oral health and disease experience among adults in China and NZ

Abstract

Objectives

Differences in oral health perceptions complicate comparisons of self-reported oral health in countries with considerably different cultures, traditions, and dental care. We compared it in China and New Zealand (NZ), to determine whether adults in those countries differ in how self-report oral health item responses distinguish those with different clinical oral disease states.

Materials and methods

Analysis of representative data on dentate 35–44-year-olds and 65–74-year-olds from the 3rd National Oral Health Survey of China in 2005 (for Sichuan province) and the NZ Oral Health Survey in 2009. Self-rated oral health in the Chinese survey was assessed by asking "Overall, how would you rate your oral health?"(responses: "Very poor," "Poor," "Fair," "Good," and "Very good"). The NZ survey asked "How would you describe the health of your teeth or mouth?" (responses: "Excellent," "Very good," "Good," "Fair," or "Poor"). To enable comparability, these were combined to create a four-category ordinal measure of self-reported oral health. The slope index of inequality (SII) and the relative index of inequality (RII) determined the extent to which the four-category self-report item distinguished those with better or poorer oral status.

Results

A higher proportion of Chinese than NZ 35–44-year-olds rated their oral health as poor or fair, and the NZ proportion rating their oral health as very good was four times that observed among Chinese. The 65–74-year-olds differed even more in their overall responses. For most aspects of clinical disease experience, the two populations were responding similarly to the self-reported oral health item, although the SII and RII values were more pronounced among 35–44-year-olds in NZ than in China; among 65–74-year-olds, both countries were more similar.

Conclusions

Chinese and NZ adults' self-ratings reflect their oral disease experience in largely similar ways, despite considerable absolute differences.

Clinical relevance

These findings support the cross-cultural applicability of self-report oral health measures.

https://ift.tt/2RaLzZB

Relationship between folate concentration and expression of folate-associated genes in tissue and plasma after intraoperative administration of leucovorin in patients with colorectal cancer

Abstract

Purpose

The aim of study was to investigate the relationship between folate concentration and expression of folate-associated genes in tumour, mucosa and plasma of patients with colorectal cancer, after intraoperative administration of bolus leucovorin (LV).

Methods

Eighty patients were randomized into four groups to receive 0, 60, 200, or 500 mg/m² LV, respectively. Tissue and plasma folate concentrations were assessed by LC–MS/MS. Gene expression of ABCC3/MRP3, FPGS, GGH, MTHFD1L, SLC46A1/PCFT, and SLC19A1/RFC-1 was determined using quantitative PCR.

Results

The folate concentration in tumour increased with increasing dosage of LV. Half of the patients treated with 60 mg/m² did not reach a level above the levels of untreated patients. A significant correlation between folate concentration in tumour and mucosa was found in untreated patients, and in the group treated with 60 mg/m² LV. The 5-MTHF/LV ratio correlated negatively with folate concentration in mucosa, whereas a positive correlation was found in tumour of patients who received 200 or 500 mg/m² LV. A positive correlation was found between folate concentration and expression of all genes, except MTHFD1L, in patients who received LV. There was a negative correlation between 5-MTHF concentration in plasma of untreated patients and expression of GGH and SLC46A1/PCFT in tumour.

Conclusions

The results indicate the possibility of using the individual plasma 5-MTHF/LV ratio after LV injection as a surrogate marker for tissue folate concentration. Expression of several folate-associated genes is associated with folate concentration in tissue and plasma and may become useful when predicting response to LV treatment.

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Endogenous IL-10 maintains immune tolerance but IL-10 gene transfer exacerbates autoimmune cholangitis

Publication date: Available online 28 September 2018

Source: Journal of Autoimmunity

Author(s): Yu-Hsin Hsueh, Hung-Wen Chen, Bi-Jhen Syu, Chia-I. Lin, Patrick S.C. Leung, M. Eric Gershwin, Ya-Hui Chuang

Abstract

The immunomodulatory effect of IL-10 as an immunosuppressive and anti-inflammatory cytokine is well known. Taking advantage of our established mouse model of autoimmune cholangitis using 2-octynoic acid conjugated ovalbumin (2-OA-OVA) induction, we compared liver pathology, immune cell populations and antimitochondrial antibodies between IL-10 knockout and wild type mice immunized with 2-OA-OVA. At 10 weeks post immunization, portal inflammation and fibrosis were more severe in 2-OA-OVA immunized IL-10 knockout mice than in wild type mice. This was accompanied by significant higher levels of collagen I and III expression, T, NK and NKT subsets in liver and IgG anti-mitochondrial autoantibodies (AMAs) compared to 2-OA-OVA immunized wild type mice, suggesting that endogenous IL-10 is necessary for the maintenance of immune tolerance in primary biliary cholangitis (PBC). Further, we investigated whether administration of exogenous IL-10 could prevent PBC by administration of IL-10 expressing recombinant adeno-associated virus (AAV-IL-10) either 3 days before or 3 weeks after the establishment of liver pathology. Interestingly, administration of AAV-IL-10 resulted in increased liver inflammation and fibrosis, accompanied by increases in IFN-γ in liver CD4⁺ T cell, granzyme B, FasL, and CD107a in liver CD8⁺ T and NKT cells, and granzyme B and FasL in liver NK cells of AAV-IL-10 administered mice compared with control mice. Furthermore, administration of AAV-IL-10 significantly increased levels of proinflammatory cytokines and chemokines (IFN-γ, TNF-α, CXCL9 and CXCL10) and collagen I and III production in naïve mice, together with increase in immune cell infiltration and collagen deposition in the liver, suggesting a role of IL-10 in fibrosis. In conclusion, our data demonstrate that endogenous IL-10 is critical in the maintenance of immune tolerance but exogenous administration of IL-10 exacerbates liver inflammation and fibrosis. Furthermore, the distinctive presence of inflammatory immune cell populations and collagen expression in AAV-IL-10 treated naïve mice cautions against the clinical use of exogenous IL-10 in patients with autoimmune cholangitis.

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Scholar : Acta Odontologica Scandinavica, Volume 76, Issue 7, October 2018 is now available online on Taylor & Francis Online

The online platform for Taylor & Francis Online content Acta Odontologica Scandinavica, Volume 76, Issue 7, October 2018 is now available online on Taylor & Francis Online. This new issue contains the following articles: Original Article Approximal sealings on lesions in neighbouring teeth requiring operative treatment: an in vitro study Alvaro Cartagena, Azam Bakhshandeh & Kim Rud Ekstrand Pages: 459-465 | DOI: 10.1080/00016357.2018.1436191 Association between age at asthma diagnosis and tooth loss Hyungkil Choi, Kwang-Hak Bae & Jeong-Woo Lee Pages: 466-472 | DOI: 10.1080/00016357.2018.1436723 Effect of resin infiltration and microabrasion on the microhardness, surface roughness and morphology of incipient carious lesions Basak Yazkan & R. Banu Ermis Pages: 473-481 | DOI: 10.1080/00016357.2018.1437217 A method for preventive intervention regarding temporomandibular pain and dysfunction Saghafi Ellie & Mejersjö Christina Pages: 482-487 | DOI: 10.1080/00016357.2018.1439529 A new methodology for the measurement of the root canal curvature and its 3D modification after instrumentation Asterios Christodoulou, Georgios Mikrogeorgis, Triantafillia Vouzara, Konstantinos Papachristou, Christos Angelopoulos, Nikolaos Nikolaidis, Ioannis Pitas & Kleoniki Lyroudia Pages: 488-492 | DOI: 10.1080/00016357.2018.1440321 Cumulative use of salivary markers with an adaptive design improves detection of periodontal disease over fixed biomarker thresholds Ulvi Kahraman Gürsoy, Pirkko J. Pussinen, Veikko Salomaa, Sanna Syrjäläinen & Eija Könönen Pages: 493-496 | DOI: 10.1080/00016357.2018.1441436 Review Article Augmented reality in dentistry: a current perspective Ho-Beom Kwon, Young-Seok Park & Jung-Suk Han Pages: 497-503 | DOI: 10.1080/00016357.2018.1441437 Original Article Illicit drug use and traumatic dental injuries in adolescents Mareeshty Damarasingh, Wagner Marcenes, Stephen A. Stansfeld & Eduardo Bernabé Pages: 504-508 | DOI: 10.1080/00016357.2018.1444200 Relationship between depth of approximal caries lesions and presence of bacteria in the dentine in primary and permanent posterior teeth: a radiographic examination with microbiological evaluation Azam Bakhshandeh, Isabela Floriano, Mariana Minatel Braga, Kristine Arnholdt Thorlacius & Kim Rud Ekstrand Pages: 509-514 | DOI: 10.1080/00016357.2018.1444201 Ten-year follow-up on adoption of endodontic technology and clinical guidelines amongst Danish general dental practitioners Merete Markvart, Helena Fransson, EndoReCo & Lars Bjørndal Pages: 515-519 | DOI: 10.1080/00016357.2018.1447684 Distribution of Porphyromonas gingivalis fimA genotypes in patients affected by rheumatoid arthritis and periodontitis José Luis Ayala-Herrera, Carlos Abud-Mendoza, Roberto F. Gonzalez-Amaro, Leon Francisco Espinosa-Cristobal & Rita Elizabeth Martínez-Martínez Pages: 520-524 | DOI: 10.1080/00016357.2018.1469788 Association of risk factors with temporomandibular disorders in the Northern Finland Birth Cohort 1966 Päivi Jussila, Jarno Knuutila, Sampo Salmela, Ritva Näpänkangas, Jari Päkkilä, Pertti Pirttiniemi & Aune Raustia Pages: 525-529 | DOI: 10.1080/00016357.2018.1479769 Self-reportance of temporomandibular disorders in adult patients attending general dental practice in Sweden from 2011 to 2013 Bengt Adèrn, Ava Minston, Eva Nohlert & Åke Tegelberg Pages: 530-534 | DOI: 10.1080/00016357.2018.1487076 Letter to the Editor Intraosseous anaesthesia as a primary technique for mandibular posterior teeth with symptomatic irreversible pulpitis Thierry Collier Pages: 535-537 | DOI: 10.1080/00016357.2018.1489558 A response for Effect of intraosseous injection versus inferior alveolar nerve block as primary pulpal aesthesia of mandibular posterior teeth with symptomatic irreversible pulpitis: a prospective randomized clinical trial Alireza Farhad, Hamid Razavian & Maryam Shafiee Pages: 538-538 | DOI: 10.1080/00016357.2018.1497578 To update which email alerts you receive, manage your alerts within the My Account area. Unsubscribe from new content alerts for this journal (both new issue and latest article notifications) with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Japan Singapore Skin Conference 2019

Publication date: October 2018

Source: Journal of Dermatological Science, Volume 92, Issue 1

Author(s):

https://ift.tt/2NTv72h

The Editor's Choice

Publication date: October 2018

Source: Journal of Dermatological Science, Volume 92, Issue 1

Author(s):

https://ift.tt/2N95ODV

Editorial board

Publication date: October 2018

Source: Journal of Dermatological Science, Volume 92, Issue 1

Author(s):

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Scholar : African Journal of Marine Science, Volume 40, Issue 3, September 2018 is now available online on Taylor & Francis Online

The online platform for Taylor & Francis Online content African Journal of Marine Science, Volume 40, Issue 3, September 2018 is now available online on Taylor & Francis Online. This new issue contains the following articles: Research Papers Occurrence and ingestion of microplastics by zooplankton in Kenya's marine environment: first documented evidence C Kosore, L Ojwang, J Maghanga, J Kamau, A Kimeli, J Omukoto, N Ngisiag'e, J Mwaluma, H Ong'ada, C Magori & E Ndirui Pages: 225-234 | DOI: 10.2989/1814232X.2018.1492969 Evaluating the effects of catch-and-release angling on Cape stumpnose Rhabdosargus holubi in a South African estuary NK Arkert, A-R Childs, MC Parkinson, AC Winkler, E Butler, S Mannheim & WM Potts Pages: 235-244 | DOI: 10.2989/1814232X.2018.1494041 Macroparasites of angelfish Brama brama (Bonnaterre, 1788) in the southern Benguela Current ecosystem AL Mackintosh, CC Reed, MAI Nunkoo, PH King & CD van der Lingen Pages: 245-252 | DOI: 10.2989/1814232X.2018.1499551 Wintertime rates of net primary production and nitrate and ammonium uptake in the southern Benguela upwelling system RF Flynn, JM Burger, K Pillay & SE Fawcett Pages: 253-266 | DOI: 10.2989/1814232X.2018.1502095 Effect of graded levels of dietary carbohydrate on growth, feed utilisation and intestinal microbial community structure in dusky kob Argyrosomus japonicus fed a pelleted diet NC Mabasa, PJ Britz, CLW Jones & A Nel Pages: 267-277 | DOI: 10.2989/1814232X.2018.1503969 Assessment of the likely sensitivity to climate change for the key marine species in the southern Benguela system K Ortega-Cisneros, S Yokwana, W Sauer, K Cochrane, A Cockcroft, NC James, WM Potts, L Singh, M Smale, A Wood & G Pecl Pages: 279-292 | DOI: 10.2989/1814232X.2018.1512526 Data-moderate assessments of Cape monkfish Lophius vomerinus and west coast sole Austroglossus microlepis in Namibian waters JN Kathena, A Kokkalis, MW Pedersen, JE Beyer & UH Thygesen Pages: 293-302 | DOI: 10.2989/1814232X.2018.1512527 Socioeconomic dynamics of the Ghanaian tuna industry: a value-chain approach to understanding aspects of global fisheries E Drury O'Neill, NK Asare & DW Aheto Pages: 303-313 | DOI: 10.2989/1814232X.2018.1513866 Short communication Quantifying the largest aggregation of giant trevally Caranx ignobilis (Carangidae) on record: implications for management R Daly, CAK Daly, RH Bennett, PD Cowley, MAM Pereira & JD Filmalter Pages: 315-321 | DOI: 10.2989/1814232X.2018.1496950 Environmental responses of jellyfish polyps as drivers of medusa populations off the coast of Namibia L Ziegler & MJ Gibbons Pages: 323-329 | DOI: 10.2989/1814232X.2018.1500397 Coral reefs of the Glorieuses Islands, western Indian Ocean MH Schleyer, L Bigot & Y Benayahu Pages: 331-339 | DOI: 10.2989/1814232X.2018.1512525 Corrigendum Corrigendum Pages: 341-341 | DOI: 10.2989/1814232X.2018.1521505 Hoping to have your article read by anyone, anywhere and at any time? Find out more about publishing open access with Ecosystem Health and Sustainability. To update which email alerts you receive, manage your alerts within the My Account area. Unsubscribe from new content alerts for this journal (both new issue and latest article notifications) with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

CDKN2A germline mutations are not associated with poor survival in an Italian cohort of melanoma patients

Publication date: Available online 28 September 2018

Source: Journal of the American Academy of Dermatology

Author(s): Bruna Dalmasso, Lorenza Pastorino, Giulia Ciccarese, Virginia Andreotti, Federica Grillo, Luca Mastracci, Francesco Spagnolo, Alberto Ballestrero, Paola Queirolo, William Bruno, Paola Ghiorzo

Background

Cyclin dependent kinase inhibitor 2A gene (CDKN2A) germline mutations have recently been associated with poor survival in patients with melanoma. Despite the high mutation rate in our cohort (up to 10% in patients with apparently sporadic melanoma), information on the impact of CDKN2A on survival in this cohort is lacking.

Objective

To investigate whether poor survival associated with CDKN2A germline mutations was confirmed in a high mutation–prevalence cohort of Italian patients with melanoma undergoing a mutation-based follow-up.

Methods

A total of 1239 patients with cutaneous melanoma were tested for CDKN2A mutational status and then assigned to a follow-up scheme according not only to family history but also to CDKN2A mutational status, as follow-up intervals were more frequent for CDKN2A germline mutation–positive (MUT⁺) patients. From this cohort, we selected 106 MUT⁺ patients (with familial melanoma or apparently sporadic melanoma) and 199 CDKN2A germline mutation–negative (MUT^–) patients with sporadic melanoma who were matched by age and sex and had a similar tumor stage distribution.

Results

We found no difference in overall survival (hazard ratio, 0.85; 95% confidence interval, 0.48-1.52; P = .592,) or melanoma-specific survival (hazard ratio, 0.86; 95% confidence interval, 0.38-1.95; P = .718,) between MUT⁺ and MUT^– patients. MUT⁺ patients were more likely to develop multiple melanomas and to undergo surgical excision of dysplastic nevi than were MUT^– patients.

Limitations

Retrospective study.

Conclusion

CDKN2A mutations were not associated with survival in our cohort.

https://ift.tt/2OZ0d50

Scholar : International Journal of Heritage Studies, Volume 24, Issue 10, December 2018 is now available online on Taylor & Francis Online

The online platform for Taylor & Francis Online content International Journal of Heritage Studies, Volume 24, Issue 10, December 2018 is now available online on Taylor & Francis Online. This new issue contains the following articles: Original Articles Dilemma of local socio-economic perspectives in management of historic ruins in Kilwa Kisiwani World Heritage Site, Tanzania Noel Biseko Lwoga Pages: 1019-1037 | DOI: 10.1080/13527258.2018.1430604 Articles Identifying sites at risk from illicit metal detecting: from CRAVED to HOPPER Louise Grove, Adam Daubney & Alasdair Booth Pages: 1038-1052 | DOI: 10.1080/13527258.2018.1475408 Intramuros: memory, violence and national becoming in Manila Robert Mason & Lauren Istvandity Pages: 1053-1067 | DOI: 10.1080/13527258.2018.1475405 Learning from cultural engagements in community-based heritage scholarship Alicia Ebbitt McGill Pages: 1068-1083 | DOI: 10.1080/13527258.2018.1475413 Book Reviews California mission landscapes: race, memory, and the politics of heritage Elizabeth Kryder-Reid, Minneapolis, University of Minnesota Press, 2016, xv + 355 pp., $35.00 (paperback), ISBN 978-0-8166-3797-3 James I. Deutsch Pages: 1084-1085 | DOI: 10.1080/13527258.2018.1475412 Book review Ross J. Wilson Pages: 1085-1087 | DOI: 10.1080/13527258.2018.1475415 To update which email alerts you receive, manage your alerts within the My Account area. Unsubscribe from new content alerts for this journal (both new issue and latest article notifications) with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : ΜΑΣΤΟΕΙΔΙΤΙΣ - νέα αποτελέσμ

[PDF] AMSER Case of the Month July 2018

B Park, K Xie - 2018

… T1 Post Contrast Final Diagnosis Left sphenoid/ethmoid sinusitis, mastoiditis and left
temporal subdural empyema Page 9 … Etiology – Bacterial infections gain access to the
subdural space by direct extension of frontal sinusitis, mastoiditis, otitis media or most …

Low-dose non-contrast examination of the temporal bone using volumetric 320-row computed tomography

B Pirimoglu, R Sade, MS Sakat, G Polat, M Kantarci - Acta Radiologica, 2018

Background 320-row volume computed tomography (CT) allows CT dose to be reduced
while maintaining image quality. Purpose To evaluate image quality of low-dose n...

[PDF] Septic thrombophlebitis of the sigmoid sinus after vestibular schwannoma resection: A case report and

TP Brito, HF Pauna, RC Pereira, RV de Araújo Rego…

… Correspondence to: Henrique Furlan Pauna, Department of
Otorhinolaryngology, Head and Neck Surgery, University of Campinas
(UNICAMP), Campinas, São Paulo, Brazil, E-mail: h_pauna@hotmail.com …

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ЛС Овчаренко, АО Вертегел, ТГ Андрієнко…

… 13(1): 1—4. https://ift.tt/2IsNQM8; PMid:23355360.
4. Gorphe P, de Barros A, Choussy O et al. 2012. Acute mastoiditis in
children: 10 years experience in a French tertiary university referral center …

[PDF] Fiebre de origen desconocido en niños

JR Contreras, ID Lorenzo

… Infecciones Bacterianas Víricas Fúngicas Parasitarias Tuberculosis
Brucelosis Fiebre tifoidea Bartonelosis Osteomielitis Endocarditis
Leptospirosis Abscesos abdominales Mastoiditis Pielonefritis Sinusitis …

 

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