A 68‐year‐old man presented for excision of a nodule on his right sub‐mandibular neck that had grown quickly over a three‐month period. Initially, it looked like an "ingrown hair," and he admitted to expressing blood‐tinged fluid from the nodule multiple times.
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Gastric cancer (GC) ranks among the most lethal epithelial malignancies, and its striking mortality rate prompts a global prevention strategy. Helicobacter pylori (H. pylori) gastritis is the main GC promoter, and the 2014 Global Kyoto conference recognized H. pylori gastritis as a (treatable) infectious disease. It is therefore plausible that any large‐scale intervention for H. pylori eradication would result in cleansing the world of the fifth cause of cancer‐related death. Atrophic gastritis is the cancerization field in which GCs (both intestinal and diffuse histotypes) mainly develop. Discontinuing the inflammatory cascade triggered by H. pylori is tantamount to preventing GC. For patients (still infected or eradicated) who have already developed gastric atrophy, the severity/topography of the atrophic changes correlates with their cancer risk. Gastritis OLGA (Operative Link for Gastritis Assessment) staging consistently ranks the atrophy‐associated cancer risk, providing a solid clinical/biological rationale for establishing patient‐specific surveillance programs. By combining primary and secondary prevention strategies, gastric cancer is a preventable disease.
Publication date: Available online 16 February 2019
Source: Journal of the American Academy of Dermatology
Author(s):
Publication date: Available online 16 February 2019
Source: Journal of the American Academy of Dermatology
Author(s):
Publication date: Available online 16 February 2019
Source: Journal of the American Academy of Dermatology
Author(s):
Facial appearance has increasing importance to individuals and women, in particular. Till date, there are no reports of the extrinsic factors influencing skin aging in Nepalese population.
To assess the risk factors and self‐perception for facial aging in Nepalese population.
A cross‐sectional study was conducted among 110 attendees aged 30‐70 years visiting the dermatology outpatient department of B.P. Koirala Institute of Health Sciences. An interview of the attendees was conducted to establish their perceived risk factors and age knowledge based on a questionnaire. The facial wrinkling was estimated by facial wrinkle scores using standardized visual assessment method by a dermatologist who was blinded with regard to all risk factors and age of the subjects.
Around 50% of attendees were conscious about facial health, 53% perceived their facial age as their chronological age, 39% used some facial care products, and 68% were aware of the risk factors for facial aging. The major perceived risk factors were unhealthy eating habits, stress, less exercise, dehydration, diseased state and sleeping habits. A significant association was found between increasing age, place of birth in hills or mountains and sun exposure with high wrinkling score.
Facial skin wrinkles can be considered as a marker for intrinsic aging. Though the main factor responsible for extrinsic aging is ultraviolet radiation, identification of the factors may help in motivating the individuals for the adoption of a range of healthy behaviors for facial age in Nepalese population that may provide important public health benefits.
